miRTarBase - #MIRT096824


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pre-miRNA Information
pre-miRNA hsa-mir-4251   
Genomic Coordinates chr1: 3127975 - 3128035
Description Homo sapiens miR-4251 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4251
Sequence 35| CCUGAGAAAAGGGCCAA |51
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs529666453 6 dbSNP
rs761641851 13 dbSNP
rs1417009298 15 dbSNP
rs915117785 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZSWIM6   
Synonyms AFND
Description zinc finger SWIM-type containing 6
Transcript NM_020928   
Expression
Putative miRNA Targets on ZSWIM6
3'UTR of ZSWIM6
(miRNA target sites are highlighted)		 
>ZSWIM6|NM_020928|3'UTR
   1 TAGATCTTGTATGAATGGGGTGGGGGGTGGGGATGGGAGGGATGGTTTGTTTTTACTTGAGCCTGCCTTTGTACCCTTTT
  81 TAACTTAAAGAACAGAGCCACACCGGTATTATATGTGTATAGTTATATTGCGTTTGCAGACTAAATTGTCATGTTGTGAA
 161 AGTTTGTGTGTTTTTTATTTTTTCCCTATTTCTTTCTTTCCTTTATTTTATTATTTTTTTTAATTTTTTTTTTCTGGTTT
 241 TGTATGAGAGAGAGGTTAAAAAGGTTTGGTTTACACTGAGTATATGTTGTCAAGTGGCAAAAGTCCACATAGCTCTCCTG
 321 TTTTCTGTATACGTTCACAGCCTCAAAAAAAATAATTGAAATGGCTTTAAAAACCAAACAAAACACCTCCATCCTGTGAT
 401 AAGTACCTCGAATGGATTCAGCTTTACTCCTTTGTAACTCATCTTTACATTTTCAGCATATTTAAACAAACCAACAAAAT
 481 GAAATACTAATAGTAAAAAGGCTGACCCATGTGGCTTTGCAGTGCTGTTCGTCCAGAAGCATGGCACACGATGCTTGTGC
 561 ATGTGGAAACTTAGCGACTGTCAACATACATTCTCAGGGATTTATCCAAAAAAATTAAAAAAAGAATGAGAGCATTTATT
 641 GTACTGTATATATATTATAGTATATGTCTGAATATTGAAAATATAACATTAACTAATTTATAAAAAATATTCTATGTAAT
 721 GCAAAATACTTGAAGCTGCAGTAGCTTGGTTTTAAACAAAAACAAAAAAAAAACTGAGAGAAAACCTATCAGAAGGACTA
 801 AAAGTACGCCTTGCTTCAGGGTTGGCTCAGGTGGTGAACTTCATGCTGGGCATCTATGCAGAGCCACCTTTTGGATTGCA
 881 TGGTTGGACTGAGATCTATTGGGAGAAATTATATATGTATATATATTTATACAACTTATGTATACATATATATATGTATA
 961 CACACAGACACACACACACACCACCAACAACCACCACTACACCACACATGCTTATAACAGGCACTAGAATAAAGAGGGAC
1041 AACAAAATACACAGCCAGAGCAGCAAGCCTTAGCATTAAGAATATACAATATGCCGGAATTGGGGTTCGTGCCTCCTAGC
1121 CTAGGAAACTTAAAAGAAATATCCTTTTGACACAAAACACAAAATGTTTTCCAAAACAATTGACATAATGATACATTACG
1201 CCTTTGCAGTGAGCTAATAATAAGCTAACCTTTGTGCACAAATAACATTATATATATTATATATCTATTCTGCATAGGTA
1281 TTTTGACTTTGTGCAGGACAGAAAGTTGTGTAGGTATGACTGTTCTACTTTTCAGTTTTCTTTTTTTTTAATATATTTTA
1361 TTTTCTCTAGAAATTACTCAAACAAAAGCAGCCTTCTATCTTGCCTTGTCTTAATGCTTTAAAATAACCAAACTGGAGAT
1441 CTAACTACCAAACTGTTCATTATATTATTAAATACCAACTTTGGTTACAGTATAGTGTCTTTACTTTAGCTGATGGTTCT
1521 GTAACCTTGTGCTTTTTAAAGCAATTTTTATGTTTTGGTGCAAAAGTTGTCCAGTGTCTCTTGTTCCCTTCACTAGAGAA
1601 CATGCTTAGAGGTATGTTTGTAGGTATTTTTGTTTAGAAGAACTATTTCATGCGCTCCATTTTATTTATTATAATAGGTA
1681 AAAAGAAAAAAAAAGGTTGTAATTCATCACCCATGTAAACATGCTCATGAAGTTGAAAGTAATTAAGATTTGATACACTG
1761 ATATCAATTTATTTATGTAACTAAATCACTGTTTTATAAACTTGTTAATGATCAACAATTTTTGTTTTGATTAAAATTAG
1841 TTTTTTGAAAGTTGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaccgggaaAAGAGUCc 5'
                   ||||||| 
Target 5' caacatacaTTCTCAGg 3'
 582 - 598 140.00 -11.60
2 
miRNA  3' aacCGGGA-AAAGAGUCc 5'
             |::||  ||:|||| 
Target 5' actGTTCTACTTTTCAGt 3'
 1319 - 1336 130.00 -7.60
3 
miRNA  3' aaccGGGAA---AAGAGUCc 5'
              :|:||   ||:|||| 
Target 5' ctcaTCTTTACATTTTCAGc 3'
 438 - 457 129.00 -6.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20944171 104 COSMIC
COSN2113186 112 COSMIC
COSN30658942 169 COSMIC
COSN28405860 222 COSMIC
COSN20081006 234 COSMIC
COSN32065716 314 COSMIC
COSN20101296 774 COSMIC
COSN32056308 880 COSMIC
COSN15320120 1381 COSMIC
COSN17132059 1454 COSMIC
COSN26763372 1584 COSMIC
COSN22643933 1650 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1304850597 2 dbSNP
rs949420324 5 dbSNP
rs1211741410 10 dbSNP
rs1350639723 15 dbSNP
rs748968133 16 dbSNP
rs761652403 16 dbSNP
rs1226711267 18 dbSNP
rs1042366779 19 dbSNP
rs1308371032 20 dbSNP
rs143893602 21 dbSNP
rs1245145638 22 dbSNP
rs750163289 23 dbSNP
rs1194300554 24 dbSNP
rs1253593271 25 dbSNP
rs1455519664 26 dbSNP
rs755897542 27 dbSNP
rs1418530271 28 dbSNP
rs1410263476 29 dbSNP
rs1172115923 30 dbSNP
rs1347712094 31 dbSNP
rs1439573052 32 dbSNP
rs766712882 33 dbSNP
rs1325968180 34 dbSNP
rs190510761 40 dbSNP
rs1054070969 42 dbSNP
rs893739644 45 dbSNP
rs1477801130 49 dbSNP
rs1433522575 50 dbSNP
rs576591313 50 dbSNP
rs1245167916 51 dbSNP
rs1201337367 59 dbSNP
rs1000943564 62 dbSNP
rs1262648087 74 dbSNP
rs545183477 76 dbSNP
rs1050434461 87 dbSNP
rs996549975 87 dbSNP
rs890479134 99 dbSNP
rs779627872 105 dbSNP
rs892987135 106 dbSNP
rs1235045355 109 dbSNP
rs1345527733 116 dbSNP
rs1159597420 122 dbSNP
rs565255755 124 dbSNP
rs962150636 127 dbSNP
rs572378727 132 dbSNP
rs1028299685 133 dbSNP
rs1414237547 140 dbSNP
rs1423574878 153 dbSNP
rs1028254327 155 dbSNP
rs1174528317 159 dbSNP
rs568297198 171 dbSNP
rs1422936412 189 dbSNP
rs1336152615 191 dbSNP
rs1191622574 193 dbSNP
rs1487244615 196 dbSNP
rs182347312 202 dbSNP
rs916233043 202 dbSNP
rs1441628096 210 dbSNP
rs1201763193 213 dbSNP
rs970423657 213 dbSNP
rs1276977004 214 dbSNP
rs1454750668 214 dbSNP
rs981821269 214 dbSNP
rs1341884317 218 dbSNP
rs986505960 222 dbSNP
rs1448023187 223 dbSNP
rs1357716257 224 dbSNP
rs765370125 224 dbSNP
rs1334898074 225 dbSNP
rs1015251054 226 dbSNP
rs1281144573 235 dbSNP
rs1321328706 237 dbSNP
rs1222431045 243 dbSNP
rs1263183775 245 dbSNP
rs1462400925 246 dbSNP
rs1186969134 247 dbSNP
rs561163516 251 dbSNP
rs935134352 261 dbSNP
rs530100961 262 dbSNP
rs1461637764 263 dbSNP
rs1257000006 264 dbSNP
rs961449434 268 dbSNP
rs184492192 270 dbSNP
rs1308236970 283 dbSNP
rs1228194532 284 dbSNP
rs1377649380 287 dbSNP
rs1366121158 301 dbSNP
rs919647082 308 dbSNP
rs959574252 309 dbSNP
rs1479732626 310 dbSNP
rs990939699 311 dbSNP
rs755368595 314 dbSNP
rs1471089826 316 dbSNP
rs78744195 333 dbSNP
rs1008860860 334 dbSNP
rs1042397752 340 dbSNP
rs1164203011 352 dbSNP
rs1330623627 354 dbSNP
rs139724675 355 dbSNP
rs897933433 356 dbSNP
rs936643026 376 dbSNP
rs1053880783 391 dbSNP
rs1481416663 393 dbSNP
rs1232903026 394 dbSNP
rs551572829 395 dbSNP
rs565438353 410 dbSNP
rs1024600114 415 dbSNP
rs996717284 416 dbSNP
rs1292631107 422 dbSNP
rs1224797431 423 dbSNP
rs1247436310 429 dbSNP
rs188746775 435 dbSNP
rs527543615 457 dbSNP
rs923654651 465 dbSNP
rs956467576 471 dbSNP
rs989657752 474 dbSNP
rs1490010794 492 dbSNP
rs1199262386 498 dbSNP
rs1434377079 503 dbSNP
rs1269711297 520 dbSNP
rs1165385923 528 dbSNP
rs1008136684 532 dbSNP
rs1379389481 550 dbSNP
rs1156635707 555 dbSNP
rs915075569 560 dbSNP
rs931841271 563 dbSNP
rs1050270439 576 dbSNP
rs1270419579 577 dbSNP
rs1462667644 608 dbSNP
rs1223803711 612 dbSNP
rs1015897565 616 dbSNP
rs1242734081 622 dbSNP
rs961090754 624 dbSNP
rs1300836227 625 dbSNP
rs944686895 626 dbSNP
rs1369729388 628 dbSNP
rs1303848215 634 dbSNP
rs1363430955 635 dbSNP
rs1036335526 636 dbSNP
rs1359856015 642 dbSNP
rs897850925 645 dbSNP
rs1455132026 649 dbSNP
rs930729018 652 dbSNP
rs1174836789 654 dbSNP
rs1431110355 664 dbSNP
rs1430731370 667 dbSNP
rs1199556475 676 dbSNP
rs995546816 682 dbSNP
rs1261631103 687 dbSNP
rs1303619829 688 dbSNP
rs1026769110 689 dbSNP
rs1347319274 690 dbSNP
rs547661956 694 dbSNP
rs1208209314 708 dbSNP
rs1325950550 708 dbSNP
rs1283957727 715 dbSNP
rs1218057106 723 dbSNP
rs1338582987 725 dbSNP
rs1049653086 742 dbSNP
rs1385062435 749 dbSNP
rs1380088976 754 dbSNP
rs1383856656 758 dbSNP
rs1385329860 758 dbSNP
rs1294211325 761 dbSNP
rs1464197447 762 dbSNP
rs11406379 764 dbSNP
rs1195867272 764 dbSNP
rs1429638843 764 dbSNP
rs201261810 764 dbSNP
rs397997948 764 dbSNP
rs528880415 764 dbSNP
rs755313190 764 dbSNP
rs548930558 768 dbSNP
rs894638014 769 dbSNP
rs1013501379 773 dbSNP
rs1326703308 775 dbSNP
rs75196744 775 dbSNP
rs1316140169 781 dbSNP
rs1431044148 786 dbSNP
rs1229458054 791 dbSNP
rs959380326 798 dbSNP
rs368049674 801 dbSNP
rs918070544 805 dbSNP
rs1277234969 808 dbSNP
rs1311977231 809 dbSNP
rs539022534 823 dbSNP
rs1357664898 829 dbSNP
rs1336981253 838 dbSNP
rs1445582433 845 dbSNP
rs1397422726 851 dbSNP
rs1222402515 857 dbSNP
rs1462907299 868 dbSNP
rs1368367324 882 dbSNP
rs978329936 899 dbSNP
rs149348639 900 dbSNP
rs924146341 918 dbSNP
rs1244204944 924 dbSNP
rs936695232 928 dbSNP
rs1054190951 930 dbSNP
rs1456629397 934 dbSNP
rs770377487 940 dbSNP
rs1196424514 941 dbSNP
rs932038166 949 dbSNP
rs1264783630 953 dbSNP
rs1022471675 962 dbSNP
rs867351634 967 dbSNP
rs1315482079 968 dbSNP
rs1445514087 968 dbSNP
rs375647426 968 dbSNP
rs1184906900 969 dbSNP
rs557749766 979 dbSNP
rs1391440462 980 dbSNP
rs1389457282 985 dbSNP
rs985945738 985 dbSNP
rs1195524592 986 dbSNP
rs1427115588 988 dbSNP
rs1158453579 990 dbSNP
rs890977884 990 dbSNP
rs1438273658 994 dbSNP
rs567197197 995 dbSNP
rs181228671 998 dbSNP
rs1423847116 1001 dbSNP
rs1451110452 1016 dbSNP
rs1265371012 1022 dbSNP
rs1220081141 1027 dbSNP
rs971980654 1039 dbSNP
rs1292177563 1041 dbSNP
rs576228248 1051 dbSNP
rs1239118956 1057 dbSNP
rs919254657 1063 dbSNP
rs1280911591 1076 dbSNP
rs1239401659 1081 dbSNP
rs1451506135 1083 dbSNP
rs1280836695 1084 dbSNP
rs1287810174 1087 dbSNP
rs1384986244 1089 dbSNP
rs930676124 1093 dbSNP
rs1036954782 1096 dbSNP
rs1049102311 1097 dbSNP
rs1159301686 1101 dbSNP
rs11544630 1102 dbSNP
rs1375947671 1104 dbSNP
rs894566651 1109 dbSNP
rs1381576287 1110 dbSNP
rs1480825998 1120 dbSNP
rs556022897 1130 dbSNP
rs1269483269 1131 dbSNP
rs543679615 1144 dbSNP
rs1245773621 1154 dbSNP
rs778456051 1154 dbSNP
rs948845086 1157 dbSNP
rs1045915428 1163 dbSNP
rs907400408 1164 dbSNP
rs1214213760 1179 dbSNP
rs897054568 1183 dbSNP
rs999101297 1190 dbSNP
rs569380476 1192 dbSNP
rs1027048086 1200 dbSNP
rs1210669973 1201 dbSNP
rs1328511939 1203 dbSNP
rs959143479 1207 dbSNP
rs1011962778 1213 dbSNP
rs1024653980 1226 dbSNP
rs538870442 1230 dbSNP
rs970870777 1231 dbSNP
rs1444215019 1247 dbSNP
rs1178911225 1248 dbSNP
rs1184010410 1249 dbSNP
rs760287152 1249 dbSNP
rs978199447 1251 dbSNP
rs1474393236 1253 dbSNP
rs953266665 1256 dbSNP
rs1193594104 1262 dbSNP
rs765631669 1264 dbSNP
rs985865601 1268 dbSNP
rs1031287117 1269 dbSNP
rs1205254026 1281 dbSNP
rs1323542361 1290 dbSNP
rs35824635 1301 dbSNP
rs958532314 1301 dbSNP
rs1256889906 1302 dbSNP
rs1018719551 1311 dbSNP
rs965883252 1315 dbSNP
rs1342121131 1324 dbSNP
rs1158218170 1340 dbSNP
rs1447737348 1341 dbSNP
rs971951160 1341 dbSNP
rs1338942035 1350 dbSNP
rs919168392 1350 dbSNP
rs749314585 1355 dbSNP
rs1454956836 1376 dbSNP
rs930634341 1378 dbSNP
rs1399567790 1380 dbSNP
rs1334106444 1382 dbSNP
rs985217504 1409 dbSNP
rs1404965277 1412 dbSNP
rs989522049 1454 dbSNP
rs1411766740 1465 dbSNP
rs1421543551 1470 dbSNP
rs1168480865 1489 dbSNP
rs1443773932 1490 dbSNP
rs915939343 1492 dbSNP
rs558683825 1503 dbSNP
rs572294295 1504 dbSNP
rs987573178 1514 dbSNP
rs928786978 1515 dbSNP
rs1308802987 1517 dbSNP
rs911940594 1525 dbSNP
rs796465967 1532 dbSNP
rs1306992941 1533 dbSNP
rs1053340662 1539 dbSNP
rs943885708 1545 dbSNP
rs1261299146 1546 dbSNP
rs1317628555 1548 dbSNP
rs1246924385 1553 dbSNP
rs1376398266 1559 dbSNP
rs1037268937 1574 dbSNP
rs1355253849 1576 dbSNP
rs771193095 1579 dbSNP
rs1461059400 1580 dbSNP
rs897093461 1584 dbSNP
rs1383095666 1588 dbSNP
rs1204499533 1590 dbSNP
rs931210113 1594 dbSNP
rs1048277621 1603 dbSNP
rs893392158 1608 dbSNP
rs541369661 1613 dbSNP
rs1011827099 1621 dbSNP
rs1043766902 1631 dbSNP
rs1176410182 1634 dbSNP
rs753118157 1646 dbSNP
rs1481327249 1649 dbSNP
rs1024686385 1650 dbSNP
rs185327131 1654 dbSNP
rs999739917 1655 dbSNP
rs1427940508 1661 dbSNP
rs1223658239 1671 dbSNP
rs1470006678 1679 dbSNP
rs1178059102 1680 dbSNP
rs1352395816 1685 dbSNP
rs1225685834 1686 dbSNP
rs1305126933 1686 dbSNP
rs1353510059 1686 dbSNP
rs1374072934 1686 dbSNP
rs574775147 1691 dbSNP
rs1297939266 1692 dbSNP
rs1031570997 1694 dbSNP
rs1395273217 1695 dbSNP
rs1374744257 1699 dbSNP
rs1425052526 1702 dbSNP
rs1344459720 1703 dbSNP
rs958345945 1705 dbSNP
rs1156411508 1712 dbSNP
rs990152684 1713 dbSNP
rs1029225924 1722 dbSNP
rs953363068 1733 dbSNP
rs1322846124 1740 dbSNP
rs543764415 1746 dbSNP
rs1198103937 1748 dbSNP
rs563652772 1764 dbSNP
rs912019536 1765 dbSNP
rs1224363622 1766 dbSNP
rs1281078416 1767 dbSNP
rs1479198771 1767 dbSNP
rs993296902 1779 dbSNP
rs1485707190 1790 dbSNP
rs1026209659 1802 dbSNP
rs1259345698 1802 dbSNP
rs1317774396 1807 dbSNP
rs1278232653 1808 dbSNP
rs751692250 1814 dbSNP
rs984755821 1819 dbSNP
rs915890679 1820 dbSNP
rs970086788 1821 dbSNP
rs1360944064 1837 dbSNP
rs3177235 1855 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aaccgggaaAAGAGUCc 5'
                   ||||||| 
Target 5' caacauacaUUCUCAGg 3'
 		2 - 18
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 57688.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aaccgggaaAAGAGUCc 5'
                   ||||||| 
Target 5' caacauacaUUCUCAGg 3'
 		16 - 32
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000252744.5 | 3UTR | UCAACAUACAUUCUCAGGGAUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000252744.5 | 3UTR | AAACUUAGCGACUGUCAACAUACAUUCUCAGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
98 hsa-miR-4251 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056156 OTUD1 OTU deubiquitinase 1 2 2
MIRT080004 MYL12B myosin light chain 12B 2 2
MIRT080407 ONECUT2 one cut homeobox 2 2 2
MIRT081901 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT090342 SEC61A1 Sec61 translocon alpha 1 subunit 2 8
MIRT096824 ZSWIM6 zinc finger SWIM-type containing 6 2 4
MIRT140185 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT149716 LDLR low density lipoprotein receptor 2 6
MIRT205293 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT213265 REST RE1 silencing transcription factor 2 6
MIRT254069 BACH1 BTB domain and CNC homolog 1 2 2
MIRT256251 ANKRD33B ankyrin repeat domain 33B 2 2
MIRT264966 TMEM136 transmembrane protein 136 2 2
MIRT267496 FEN1 flap structure-specific endonuclease 1 2 2
MIRT285077 MIER1 MIER1 transcriptional regulator 2 2
MIRT296167 NCOA3 nuclear receptor coactivator 3 2 2
MIRT316073 ABRACL ABRA C-terminal like 2 2
MIRT360286 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT364793 PRRC2B proline rich coiled-coil 2B 2 2
MIRT443277 TSPAN15 tetraspanin 15 2 2
MIRT443453 CLIC5 chloride intracellular channel 5 2 2
MIRT445938 KLHL32 kelch like family member 32 2 2
MIRT448012 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT448382 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 4
MIRT448499 RYBP RING1 and YY1 binding protein 2 2
MIRT449896 C11orf34 placenta expressed transcript 1 1 2
MIRT450457 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450849 HTR2A 5-hydroxytryptamine receptor 2A 2 2
MIRT453774 NUCB1 nucleobindin 1 2 10
MIRT464399 URM1 ubiquitin related modifier 1 2 2
MIRT465008 TUBB2A tubulin beta 2A class IIa 2 8
MIRT465145 TSC22D2 TSC22 domain family member 2 2 2
MIRT467799 SLC2A14 solute carrier family 2 member 14 2 2
MIRT472597 NACC1 nucleus accumbens associated 1 2 2
MIRT477969 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT486586 ZNF619 zinc finger protein 619 2 2
MIRT487739 MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 2 4
MIRT492529 PTMA prothymosin, alpha 2 6
MIRT496845 KCNIP2 potassium voltage-gated channel interacting protein 2 2 2
MIRT499064 CTBP1 C-terminal binding protein 1 2 4
MIRT502046 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT503907 ZSCAN25 zinc finger and SCAN domain containing 25 2 2
MIRT506776 KLHL15 kelch like family member 15 2 4
MIRT510003 UCP1 uncoupling protein 1 2 6
MIRT513040 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT513174 MOAP1 modulator of apoptosis 1 2 6
MIRT517592 ZNF579 zinc finger protein 579 2 4
MIRT521825 POLR1D RNA polymerase I subunit D 2 2
MIRT530663 TRIM56 tripartite motif containing 56 2 2
MIRT531718 TARS threonyl-tRNA synthetase 2 2
MIRT535154 PLEKHG5 pleckstrin homology and RhoGEF domain containing G5 2 2
MIRT536385 LEFTY1 left-right determination factor 1 2 2
MIRT543847 APIP APAF1 interacting protein 2 2
MIRT546973 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT548667 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT548799 CLIP4 CAP-Gly domain containing linker protein family member 4 2 4
MIRT549610 TMEM101 transmembrane protein 101 2 2
MIRT549716 NUP37 nucleoporin 37 2 4
MIRT549873 ZNF260 zinc finger protein 260 2 2
MIRT555383 PPP1CC protein phosphatase 1 catalytic subunit gamma 2 2
MIRT566976 LBR lamin B receptor 2 2
MIRT568052 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT570970 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT571174 ZNF85 zinc finger protein 85 2 2
MIRT571364 ZNF45 zinc finger protein 45 2 2
MIRT572309 LSM4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT572493 BTN2A2 butyrophilin subfamily 2 member A2 2 2
MIRT606783 KIAA0040 KIAA0040 2 5
MIRT607952 NFAM1 NFAT activating protein with ITAM motif 1 2 10
MIRT609978 HERPUD2 HERPUD family member 2 2 2
MIRT610069 CD300E CD300e molecule 2 2
MIRT610118 IL17REL interleukin 17 receptor E like 2 2
MIRT610151 PRMT8 protein arginine methyltransferase 8 2 4
MIRT611075 ZNF621 zinc finger protein 621 2 2
MIRT612011 COX17 COX17, cytochrome c oxidase copper chaperone 2 2
MIRT617901 PTCHD3 patched domain containing 3 2 2
MIRT618052 MRVI1 murine retrovirus integration site 1 homolog 2 2
MIRT619526 ZNF74 zinc finger protein 74 2 2
MIRT624276 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT625357 MGLL monoglyceride lipase 2 2
MIRT626756 NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 2 2
MIRT628851 FAM151B family with sequence similarity 151 member B 2 2
MIRT630458 GMPS guanine monophosphate synthase 2 2
MIRT634536 MRPS17 mitochondrial ribosomal protein S17 2 2
MIRT638806 DCTN3 dynactin subunit 3 2 2
MIRT647607 TMTC2 transmembrane and tetratricopeptide repeat containing 2 2 2
MIRT650885 PPP1R15A protein phosphatase 1 regulatory subunit 15A 2 2
MIRT653507 SLC43A2 solute carrier family 43 member 2 2 2
MIRT658608 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 2
MIRT666345 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT693743 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT704049 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT709789 CYBRD1 cytochrome b reductase 1 2 2
MIRT711837 AMOTL2 angiomotin like 2 2 2
MIRT711875 VASP vasodilator stimulated phosphoprotein 2 2
MIRT717349 RAB40A RAB40A, member RAS oncogene family 2 2
MIRT717746 MYLK myosin light chain kinase 2 2
MIRT725398 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4251 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4251 Doxorubicin 31703 NSC123127 approved resistant High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-mir-4251 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-4251 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4251 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)

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