miRTarBase - #MIRT099065


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pre-miRNA Information
pre-miRNA hsa-mir-4464   
Genomic Coordinates chr6: 90312742 - 90312833
Description Homo sapiens miR-4464 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4464
Sequence 12| AAGGUUUGGAUAGAUGCAAUA |32
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 6 + 90312764 29233923 MiREDiBase
A-to-I 14 6 + 90312766 29233923 MiREDiBase
A-to-I 19 6 + 90312771 29233923 MiREDiBase
A-to-I 21 6 + 90312773 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1240632245 2 dbSNP
rs34899210 2 dbSNP
rs1003034046 13 dbSNP
rs1475351324 14 dbSNP
rs1257582329 17 dbSNP
rs1193587810 20 dbSNP
Putative Targets

Gene Information
Gene Symbol FOXC1   
Synonyms ARA, ASGD3, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3
Description forkhead box C1
Transcript NM_001453   
Expression
Putative miRNA Targets on FOXC1
3'UTR of FOXC1
(miRNA target sites are highlighted)		 
>FOXC1|NM_001453|3'UTR
   1 CACACCCTCAAAGCCGAACTAAATCGAACCCCAAAGCAGGAAAAGCTAAAGGAACCCATCAAGGCAAAATCGAAACTAAA
  81 AAAAAAAAATCCAATTAAAAAAAACCCCTGAGAATATTCACCACACCAGCGAACAGAATATCCCTCCAAAAATTCAGCTC
 161 ACCAGCACCAGCACGAAGAAAACTCTATTTTCTTAACCGATTAATTCAGAGCCACCTCCACTTTGCCTTGTCTAAATAAA
 241 CAAACCCGTAAACTGTTTTATACAGAGACAGCAAAATCTTGGTTTATTAAAGGACAGTGTTACTCCAGATAACACGTAAG
 321 TTTCTTCTTGCTTTTCAGAGACCTGCTTTCCCCTCCTCCCGTCTCCCCTCTCTTGCCTTCTTCCTTGCCTCTCACCTGTA
 401 AGATATTATTTTATCCTATGTTGAAGGGAGGGGGAAAGTCCCCGTTTATGAAAGTCGCTTTCTTTTTATTCATGGACTTG
 481 TTTTAAAATGTAAATTGCAACATAGTAATTTATTTTTAATTTGTAGTTGGATGTCGTGGACCAAACGCCAGAAAGTGTTC
 561 CCAAAACCTGACGTTAAATTGCCTGAAACTTTAAATTGTGCTTTTTTTCTCATTATAAAAAGGGAAACTGTATTAATCTT
 641 ATTCTATCCTCTTTTCTTTCTTTTTGTTGAACATATTCATTGTTTGTTTATTAATAAATTACCATTCAGTTTGAATGAGA
 721 CCTATATGTCTGGATACTTTAATAGAGCTTTAATTATTACGAAAAAAGATTTCAGAGATAAAACACTAGAAGTTACCTAT
 801 TCTCCACCTAAATCTCTGAAAAATGGAGAAACCCTCTGACTAGTCCATGTCAAATTTTACTAAAAGTCTTTTTGTTTAGA
 881 TTTATTTTCCTGCAGCATCTTCTGCAAAATGTACTATATAGTCAGCTTGCTTTGAGGCTAGTAAAAAGATATTTTTCTAA
 961 ACAGATTGGAGTTGGCATATAAACAAATACGTTTTCTCACTAATGACAGTCCATGATTCGGAAATTTTAAGCCCATGAAT
1041 CAGCCGCGGTCTTACCACGGTGATGCCTGTGTGCCGAGAGATGGGACTGTGCGGCCAGATATGCACAGATAAATATTTGG
1121 CTTGTGTATTCCATATAAAATTGCAGTGCATATTATACATCCCTGTGAGCCAGATGCTGAATAGATATTTTCCTATTATT
1201 TCAGTCCTTTATAAAAGGAAAAATAAACCAGTTTTTAAATGTATGTATATAATTCTCCCCCATTTACAATCCTTCATGTA
1281 TTACATAGAAGGATTGCTTTTTTAAAAATATACTGCGGGTTGGAAAGGGATATTTAATCTTTGAGAAACTATTTTAGAAA
1361 ATATGTTTGTAGAACAATTATTTTTGAAAAAGATTTAAAGCAATAACAAGAAGGAAGGCGAGAGGAGCAGAACATTTTGG
1441 TCTAGGGTGGTTTCTTTTTAAACCATTTTTTCTTGTTAATTTACAGTTAAACCTAGGGGACAATCCGGATTGGCCCTCCC
1521 CCTTTTGTAAATAACCCAGGAAATGTAATAAATTCATTATCTTAGGGTGATCTGCCCTGCCAATCAGACTTTGGGGAGAT
1601 GGCGATTTGATTACAGACGTTCGGGGGGGTGGGGGGCTTGCAGTTTGTTTTGGAGATAATACAGTTTCCTGCTATCTGCC
1681 GCTCCTATCTAGAGGCAACACTTAAGCAGTAATTGCTGTTGCTTGTTGTCAAAATTTGATCATTGTTAAAGGATTGCTGC
1761 AAATAAATACACTTTAATTTCAGTCAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auAACG--UAGA--UAGGUUUGGAa 5'
            |||:  ||:|  | ::|||||| 
Target 5' tcTTGTTAATTTACAGTTAAACCTa 3'
 1471 - 1495 139.00 -7.30
2 
miRNA  3' auAACG---UAGA--UA--GGUUUGGaa 5'
            ||||   :|||  ||   ||||||  
Target 5' ctTTGCCTTGTCTAAATAAACAAACCcg 3'
 221 - 248 131.00 -8.60
3 
miRNA  3' auAACGUAGAUAGGUUUGGaa 5'
            | |: ||| |::|||||  
Target 5' ggTGGTTTCTTTTTAAACCat 3'
 1446 - 1466 127.00 -8.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1181503 106 ClinVar
183249 735 ClinVar
COSN26976635 14 COSMIC
COSN19659403 27 COSMIC
COSN30454357 31 COSMIC
COSN15624097 68 COSMIC
COSN31600803 70 COSMIC
COSN20075525 72 COSMIC
COSN27220304 90 COSMIC
COSN30131523 93 COSMIC
COSN20045745 105 COSMIC
COSN31588248 105 COSMIC
COSN8513643 172 COSMIC
COSN28770477 188 COSMIC
COSN31547489 221 COSMIC
COSN30135019 268 COSMIC
COSN30401750 279 COSMIC
COSN31517901 279 COSMIC
COSN30141708 294 COSMIC
COSN31540894 309 COSMIC
COSN30533227 345 COSMIC
COSN7697022 381 COSMIC
COSN16361054 442 COSMIC
COSN21702469 481 COSMIC
COSN30114578 494 COSMIC
COSN15968548 573 COSMIC
COSN32110299 586 COSMIC
COSN30130629 746 COSMIC
COSN30135020 762 COSMIC
COSN27213216 784 COSMIC
COSN30129855 806 COSMIC
COSN30127769 822 COSMIC
COSN31593751 833 COSMIC
COSN21529772 837 COSMIC
COSN8513644 840 COSMIC
COSN26566061 844 COSMIC
COSN30113449 864 COSMIC
COSN9971943 991 COSMIC
COSN31563382 1002 COSMIC
COSN31515894 1048 COSMIC
COSN31538095 1094 COSMIC
COSN24301808 1096 COSMIC
COSN30529972 1120 COSMIC
COSN30141029 1128 COSMIC
COSN30129866 1164 COSMIC
COSN19659404 1204 COSMIC
COSN30142326 1252 COSMIC
COSN15624098 1256 COSMIC
COSN15624099 1258 COSMIC
COSN32191710 1276 COSMIC
COSN26555098 1279 COSMIC
COSN30113761 1292 COSMIC
COSN4857222 1304 COSMIC
COSN17153524 1345 COSMIC
COSN30534033 1450 COSMIC
COSN30128834 1475 COSMIC
COSN31543010 1543 COSMIC
COSN31592770 1559 COSMIC
COSN30510390 1574 COSMIC
COSN23868924 1580 COSMIC
COSN30144139 1600 COSMIC
COSN25630585 1601 COSMIC
COSN30143578 1613 COSMIC
COSN26602065 1623 COSMIC
COSN31579436 1630 COSMIC
COSN9499950 1631 COSMIC
COSN30126227 1704 COSMIC
COSN31609183 1747 COSMIC
rs2745599 1345 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1356049082 4 dbSNP
rs550008409 6 dbSNP
rs770747430 7 dbSNP
rs1309394453 8 dbSNP
rs774178122 11 dbSNP
rs1255629093 14 dbSNP
rs569615621 16 dbSNP
rs1395644292 19 dbSNP
rs776933515 19 dbSNP
rs762444077 20 dbSNP
rs1488149748 23 dbSNP
rs753828358 24 dbSNP
rs755098873 30 dbSNP
rs199666960 31 dbSNP
rs1429781292 32 dbSNP
rs758797660 33 dbSNP
rs766539992 35 dbSNP
rs370151681 36 dbSNP
rs1351404767 37 dbSNP
rs374620749 38 dbSNP
rs781401575 46 dbSNP
rs773884905 48 dbSNP
rs748021580 49 dbSNP
rs756124189 52 dbSNP
rs73406893 53 dbSNP
rs903258348 57 dbSNP
rs534974179 58 dbSNP
rs558074909 59 dbSNP
rs933362683 72 dbSNP
rs953785432 77 dbSNP
rs1285728011 78 dbSNP
rs1334614373 78 dbSNP
rs779316749 78 dbSNP
rs1171816932 79 dbSNP
rs1461296707 89 dbSNP
rs1415913194 94 dbSNP
rs1296786615 96 dbSNP
rs1232314245 97 dbSNP
rs1473261626 97 dbSNP
rs889256919 98 dbSNP
rs116336796 106 dbSNP
rs910042588 108 dbSNP
rs537216699 110 dbSNP
rs1284073173 111 dbSNP
rs1354347813 122 dbSNP
rs1349510047 124 dbSNP
rs1277263405 130 dbSNP
rs1225469218 131 dbSNP
rs1286810804 132 dbSNP
rs557556144 137 dbSNP
rs777444017 139 dbSNP
rs972991232 145 dbSNP
rs574031863 148 dbSNP
rs1214688132 158 dbSNP
rs1025952402 159 dbSNP
rs1407613742 160 dbSNP
rs1156876480 167 dbSNP
rs746626978 169 dbSNP
rs778482299 170 dbSNP
rs1260804568 176 dbSNP
rs1381038207 182 dbSNP
rs1443885886 183 dbSNP
rs1467096969 183 dbSNP
rs1045714544 188 dbSNP
rs1222117634 193 dbSNP
rs1446052631 195 dbSNP
rs1033531452 200 dbSNP
rs1236765850 204 dbSNP
rs959454603 216 dbSNP
rs543142683 219 dbSNP
rs1234127445 220 dbSNP
rs1369429649 221 dbSNP
rs374954433 226 dbSNP
rs1295644065 236 dbSNP
rs780414480 237 dbSNP
rs915154568 238 dbSNP
rs947423341 239 dbSNP
rs977398485 246 dbSNP
rs924585817 248 dbSNP
rs1361188087 249 dbSNP
rs1173100474 251 dbSNP
rs1452497344 258 dbSNP
rs933435061 264 dbSNP
rs1396876064 267 dbSNP
rs770525624 270 dbSNP
rs1474984667 273 dbSNP
rs368696215 279 dbSNP
rs943515912 288 dbSNP
rs1156410607 290 dbSNP
rs1278905567 297 dbSNP
rs573322518 298 dbSNP
rs1037993239 306 dbSNP
rs745354528 308 dbSNP
rs1304110537 310 dbSNP
rs62390613 310 dbSNP
rs1042305444 315 dbSNP
rs1047409599 316 dbSNP
rs1268804146 317 dbSNP
rs902445399 327 dbSNP
rs1026186793 328 dbSNP
rs1312337969 333 dbSNP
rs1339287626 337 dbSNP
rs997817850 338 dbSNP
rs1003323508 339 dbSNP
rs181633430 341 dbSNP
rs959272757 347 dbSNP
rs1477940854 351 dbSNP
rs1029337099 352 dbSNP
rs953877244 354 dbSNP
rs1022049158 359 dbSNP
rs774927159 362 dbSNP
rs977951060 369 dbSNP
rs924667152 372 dbSNP
rs1017118005 373 dbSNP
rs757677458 377 dbSNP
rs962887422 378 dbSNP
rs779102893 384 dbSNP
rs748674372 392 dbSNP
rs918803355 394 dbSNP
rs527848565 395 dbSNP
rs1200893619 398 dbSNP
rs971622442 399 dbSNP
rs1277635793 403 dbSNP
rs1341337414 403 dbSNP
rs1292950487 408 dbSNP
rs987612826 416 dbSNP
rs910619308 420 dbSNP
rs981696683 422 dbSNP
rs927291357 427 dbSNP
rs1352759512 428 dbSNP
rs1172538167 434 dbSNP
rs1465989492 440 dbSNP
rs1416672414 441 dbSNP
rs1238281094 450 dbSNP
rs1037877254 451 dbSNP
rs937369274 454 dbSNP
rs1256162161 461 dbSNP
rs533280855 472 dbSNP
rs914662049 482 dbSNP
rs547974202 486 dbSNP
rs1042253141 499 dbSNP
rs902393159 504 dbSNP
rs1400479244 509 dbSNP
rs1318993382 510 dbSNP
rs933894998 523 dbSNP
rs1231619002 525 dbSNP
rs1051035997 531 dbSNP
rs1323733501 533 dbSNP
rs1313521976 534 dbSNP
rs906222374 544 dbSNP
rs1332574324 545 dbSNP
rs1399666627 546 dbSNP
rs77607008 548 dbSNP
rs1393387054 553 dbSNP
rs1054913036 574 dbSNP
rs1006985237 576 dbSNP
rs34877245 577 dbSNP
rs1010571137 580 dbSNP
rs1381663103 583 dbSNP
rs1181001203 602 dbSNP
rs1458615771 610 dbSNP
rs898244928 614 dbSNP
rs1252687696 615 dbSNP
rs1208494249 618 dbSNP
rs1489578771 620 dbSNP
rs994255163 625 dbSNP
rs1266311285 629 dbSNP
rs772515842 630 dbSNP
rs1315161024 634 dbSNP
rs1022099852 639 dbSNP
rs528961345 640 dbSNP
rs549100468 643 dbSNP
rs1390969318 644 dbSNP
rs1029993018 648 dbSNP
rs1200473920 649 dbSNP
rs954768273 650 dbSNP
rs1361835609 651 dbSNP
rs1158727827 652 dbSNP
rs1258567842 652 dbSNP
rs1440838913 653 dbSNP
rs1395068769 657 dbSNP
rs1456933278 661 dbSNP
rs1180078939 673 dbSNP
rs1197168145 675 dbSNP
rs987885802 677 dbSNP
rs1268534128 679 dbSNP
rs1204722008 680 dbSNP
rs1487434632 680 dbSNP
rs1288248870 683 dbSNP
rs1217513071 691 dbSNP
rs1347031180 692 dbSNP
rs1273050921 693 dbSNP
rs373198124 696 dbSNP
rs1331426200 697 dbSNP
rs1294603483 705 dbSNP
rs1035039962 708 dbSNP
rs958712480 710 dbSNP
rs565331544 716 dbSNP
rs1268814441 720 dbSNP
rs771651540 722 dbSNP
rs1298256399 723 dbSNP
rs1433610597 727 dbSNP
rs1433451833 728 dbSNP
rs973455445 731 dbSNP
rs990569401 732 dbSNP
rs35717904 735 dbSNP
rs946126937 736 dbSNP
rs977543159 748 dbSNP
rs1193006729 750 dbSNP
rs1476957589 753 dbSNP
rs923754485 761 dbSNP
rs1376308151 762 dbSNP
rs1478976089 763 dbSNP
rs1485365139 764 dbSNP
rs933834675 774 dbSNP
rs1202055515 776 dbSNP
rs766487149 778 dbSNP
rs889714509 785 dbSNP
rs550980014 787 dbSNP
rs928196365 790 dbSNP
rs1391501908 799 dbSNP
rs1386449675 800 dbSNP
rs942344607 801 dbSNP
rs1038444290 811 dbSNP
rs533511348 821 dbSNP
rs571583124 822 dbSNP
rs1025377885 833 dbSNP
rs537378863 835 dbSNP
rs1403615454 837 dbSNP
rs377765731 846 dbSNP
rs907364869 850 dbSNP
rs1278601164 860 dbSNP
rs557259848 861 dbSNP
rs1171595558 864 dbSNP
rs946499603 869 dbSNP
rs1043440034 882 dbSNP
rs902396688 890 dbSNP
rs1249786791 891 dbSNP
rs1196490023 900 dbSNP
rs1266733504 903 dbSNP
rs35607877 904 dbSNP
rs1353824696 916 dbSNP
rs1208885860 917 dbSNP
rs574217067 928 dbSNP
rs1034581487 938 dbSNP
rs1264749097 944 dbSNP
rs1244948411 948 dbSNP
rs959222279 953 dbSNP
rs1029465164 958 dbSNP
rs549895092 959 dbSNP
rs1194922404 966 dbSNP
rs1332467460 967 dbSNP
rs1461117583 967 dbSNP
rs1262897723 978 dbSNP
rs1022043424 986 dbSNP
rs1477149158 987 dbSNP
rs560601928 997 dbSNP
rs1473187638 998 dbSNP
rs1363328041 1005 dbSNP
rs140591342 1020 dbSNP
rs977484540 1034 dbSNP
rs371193842 1040 dbSNP
rs1017629366 1043 dbSNP
rs923368123 1045 dbSNP
rs964693942 1046 dbSNP
rs973507863 1047 dbSNP
rs1306477997 1049 dbSNP
rs1369146515 1056 dbSNP
rs573385129 1057 dbSNP
rs1238527932 1058 dbSNP
rs1027738401 1059 dbSNP
rs1310429500 1061 dbSNP
rs1436264009 1067 dbSNP
rs545386506 1068 dbSNP
rs1406195390 1076 dbSNP
rs954747882 1077 dbSNP
rs1359917061 1088 dbSNP
rs1156935391 1089 dbSNP
rs987045658 1090 dbSNP
rs190526847 1093 dbSNP
rs1298626264 1094 dbSNP
rs1476895837 1096 dbSNP
rs1248265788 1099 dbSNP
rs1199064433 1102 dbSNP
rs911099579 1105 dbSNP
rs1446074650 1106 dbSNP
rs942608051 1108 dbSNP
rs529818974 1114 dbSNP
rs939615139 1117 dbSNP
rs991075728 1123 dbSNP
rs1287411386 1132 dbSNP
rs916272695 1134 dbSNP
rs946385105 1142 dbSNP
rs1276986857 1143 dbSNP
rs1437372866 1144 dbSNP
rs1314708825 1156 dbSNP
rs1321801334 1159 dbSNP
rs1043492044 1167 dbSNP
rs1421641072 1174 dbSNP
rs1243524293 1181 dbSNP
rs1175211232 1183 dbSNP
rs902279141 1184 dbSNP
rs1426930068 1185 dbSNP
rs1191627827 1187 dbSNP
rs984253 1188 dbSNP
rs1195170946 1189 dbSNP
rs929669731 1191 dbSNP
rs1046778204 1193 dbSNP
rs182014366 1199 dbSNP
rs890934328 1204 dbSNP
rs1216843912 1207 dbSNP
rs1262956965 1219 dbSNP
rs1002963173 1228 dbSNP
rs1487482078 1228 dbSNP
rs34470720 1229 dbSNP
rs1257394346 1230 dbSNP
rs894683660 1231 dbSNP
rs1402106230 1240 dbSNP
rs1341148857 1243 dbSNP
rs1302344316 1244 dbSNP
rs1018185743 1248 dbSNP
rs35347817 1251 dbSNP
rs529133151 1253 dbSNP
rs1012235779 1256 dbSNP
rs1185582616 1257 dbSNP
rs1382223531 1259 dbSNP
rs1421246610 1260 dbSNP
rs1021899806 1270 dbSNP
rs1477949071 1272 dbSNP
rs1420573877 1279 dbSNP
rs967348287 1286 dbSNP
rs994831470 1287 dbSNP
rs186543284 1291 dbSNP
rs1030386783 1294 dbSNP
rs1211479052 1299 dbSNP
rs1457562388 1300 dbSNP
rs552498486 1303 dbSNP
rs765022070 1304 dbSNP
rs1304370247 1305 dbSNP
rs1220627774 1318 dbSNP
rs1035627483 1323 dbSNP
rs761625675 1327 dbSNP
rs1462867624 1329 dbSNP
rs2745599 1345 dbSNP
rs772836394 1347 dbSNP
rs1312332569 1349 dbSNP
rs1303315105 1352 dbSNP
rs189813928 1354 dbSNP
rs1397773979 1355 dbSNP
rs1333123102 1357 dbSNP
rs1465812437 1361 dbSNP
rs1367590270 1362 dbSNP
rs1162064279 1365 dbSNP
rs1425001424 1366 dbSNP
rs1240446654 1375 dbSNP
rs1284790010 1376 dbSNP
rs1184689387 1377 dbSNP
rs762904432 1393 dbSNP
rs963939040 1394 dbSNP
rs1315507067 1401 dbSNP
rs1439629585 1402 dbSNP
rs916825230 1405 dbSNP
rs1200982239 1408 dbSNP
rs1265128264 1408 dbSNP
rs557505558 1408 dbSNP
rs979070591 1408 dbSNP
rs767916595 1410 dbSNP
rs1313546694 1412 dbSNP
rs974379714 1417 dbSNP
rs919862089 1419 dbSNP
rs923586166 1429 dbSNP
rs763914229 1431 dbSNP
rs1046723418 1434 dbSNP
rs550941173 1435 dbSNP
rs1447308114 1440 dbSNP
rs928351040 1441 dbSNP
rs1291382417 1443 dbSNP
rs1459133442 1444 dbSNP
rs181076077 1447 dbSNP
rs1349889157 1448 dbSNP
rs752952900 1455 dbSNP
rs935089761 1461 dbSNP
rs1419617439 1465 dbSNP
rs1379059400 1466 dbSNP
rs1180870440 1477 dbSNP
rs938430342 1481 dbSNP
rs1050851728 1489 dbSNP
rs912408104 1489 dbSNP
rs1055584724 1491 dbSNP
rs1489589542 1492 dbSNP
rs3799328 1499 dbSNP
rs756309855 1500 dbSNP
rs1483235941 1503 dbSNP
rs1202296565 1504 dbSNP
rs1351387567 1514 dbSNP
rs1240129693 1518 dbSNP
rs1039676836 1529 dbSNP
rs1442402634 1531 dbSNP
rs551307028 1532 dbSNP
rs1043670673 1537 dbSNP
rs1367941744 1544 dbSNP
rs1440333143 1555 dbSNP
rs903441744 1562 dbSNP
rs185531077 1566 dbSNP
rs536815357 1573 dbSNP
rs1030334389 1574 dbSNP
rs1160920540 1575 dbSNP
rs1378774955 1577 dbSNP
rs1435119104 1579 dbSNP
rs1178030199 1581 dbSNP
rs954727073 1584 dbSNP
rs564615118 1586 dbSNP
rs553305445 1587 dbSNP
rs1465508614 1593 dbSNP
rs866492467 1599 dbSNP
rs1334548372 1602 dbSNP
rs1269927835 1606 dbSNP
rs1049107628 1611 dbSNP
rs886411391 1613 dbSNP
rs1446788581 1615 dbSNP
rs1307890453 1622 dbSNP
rs879010583 1622 dbSNP
rs1005402281 1623 dbSNP
rs1254014489 1623 dbSNP
rs1352967725 1623 dbSNP
rs566940366 1625 dbSNP
rs370514174 1626 dbSNP
rs757127346 1627 dbSNP
rs1298278221 1628 dbSNP
rs1383261911 1629 dbSNP
rs1402190184 1630 dbSNP
rs778334758 1630 dbSNP
rs1389500439 1631 dbSNP
rs34380836 1632 dbSNP
rs1302456857 1637 dbSNP
rs369046889 1647 dbSNP
rs979626594 1657 dbSNP
rs1194066891 1664 dbSNP
rs923632092 1675 dbSNP
rs1202344570 1676 dbSNP
rs1260477978 1679 dbSNP
rs1458603837 1680 dbSNP
rs1257200906 1681 dbSNP
rs1198157783 1682 dbSNP
rs1231230729 1683 dbSNP
rs1017710743 1687 dbSNP
rs1319640335 1688 dbSNP
rs1270253647 1690 dbSNP
rs1243492691 1696 dbSNP
rs543347962 1702 dbSNP
rs1340360788 1708 dbSNP
rs1332727577 1714 dbSNP
rs1398328998 1723 dbSNP
rs1407215815 1724 dbSNP
rs1331175371 1736 dbSNP
rs1464253443 1739 dbSNP
rs557172454 1743 dbSNP
rs956380500 1748 dbSNP
rs1472488367 1759 dbSNP
rs964197765 1763 dbSNP
rs1425633285 1769 dbSNP
rs533700893 1777 dbSNP
rs1445168180 1782 dbSNP
rs919809545 1785 dbSNP
rs1196586174 1786 dbSNP
rs1425767402 1786 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2296.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000380874.2 | 3UTR | UUAAACCUAGGGGACAAUCCGGAUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000380874.2 | 3UTR | UUAAACCUAGGGGACAAUCCGGAUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000380874.2 | 3UTR | UUAAUUUACAGUUAAACCUAGGGGACAAUCCGGAUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000380874.2 | 3UTR | UUAAACCUAGGGGACAAUCCGGAUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000380874.2 | 3UTR | UAAUUUACAGUUAAACCUAGGGGACAAUCCGGAUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
81 hsa-miR-4464 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056004 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT061568 BTG2 BTG anti-proliferation factor 2 2 2
MIRT078651 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT087551 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 4
MIRT088139 SEPT2 septin 2 2 4
MIRT095089 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT099065 FOXC1 forkhead box C1 2 4
MIRT150194 MIDN midnolin 2 2
MIRT178173 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT178942 C11ORF57 chromosome 11 open reading frame 57 2 2
MIRT188776 SESN2 sestrin 2 2 2
MIRT267026 EFHD2 EF-hand domain family member D2 2 2
MIRT307213 ACVR2B activin A receptor type 2B 2 2
MIRT324750 ACER2 alkaline ceramidase 2 2 2
MIRT442732 TEAD1 TEA domain transcription factor 1 2 2
MIRT444087 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT445527 KLF9 Kruppel like factor 9 2 2
MIRT449604 INIP INTS3 and NABP interacting protein 2 2
MIRT451129 ZNF99 zinc finger protein 99 2 2
MIRT452271 RPL30 ribosomal protein L30 2 2
MIRT452486 DDX4 DEAD-box helicase 4 2 2
MIRT454868 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 2 6
MIRT455773 TSPAN6 tetraspanin 6 2 4
MIRT463844 WRN Werner syndrome RecQ like helicase 2 2
MIRT465036 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT465176 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT465294 TRIB3 tribbles pseudokinase 3 2 4
MIRT467931 SLC16A7 solute carrier family 16 member 7 2 2
MIRT471906 NUAK2 NUAK family kinase 2 2 2
MIRT472724 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT479785 CCND1 cyclin D1 2 2
MIRT482446 ADM adrenomedullin 2 10
MIRT485365 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT498399 KIF6 kinesin family member 6 2 2
MIRT503202 ACTB actin beta 2 6
MIRT503819 TMEM242 transmembrane protein 242 2 2
MIRT504706 ZNF117 zinc finger protein 117 2 2
MIRT507802 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT509968 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 4
MIRT517306 ELF4 E74 like ETS transcription factor 4 2 6
MIRT523900 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT532018 NOX5 NADPH oxidase 5 2 2
MIRT535334 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT536944 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 4
MIRT539322 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT540189 GSTM4 glutathione S-transferase mu 4 2 2
MIRT545015 ZNF439 zinc finger protein 439 2 2
MIRT545265 TRIM36 tripartite motif containing 36 2 4
MIRT547230 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 4
MIRT548425 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT549910 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550185 TMEM106C transmembrane protein 106C 2 2
MIRT550775 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT552401 ZNF487P zinc finger protein 487 1 1
MIRT554782 RHEBP1 RHEB pseudogene 1 2 4
MIRT557311 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT558635 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT563168 RPS14 ribosomal protein S14 2 2
MIRT564886 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT565778 SEPHS1 selenophosphate synthetase 1 2 2
MIRT566480 PDCD4 programmed cell death 4 2 2
MIRT567206 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568931 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT570698 FBXO41 F-box protein 41 2 2
MIRT573474 MTRNR2L9 MT-RNR2-like 9 2 2
MIRT576170 Hmox1 heme oxygenase 1 2 2
MIRT607555 GLI2 GLI family zinc finger 2 2 2
MIRT608203 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609779 VWC2L von Willebrand factor C domain containing protein 2 like 2 4
MIRT616312 CELF2 CUGBP Elav-like family member 2 2 2
MIRT617190 CDH13 cadherin 13 2 2
MIRT626842 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT636438 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT639101 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT691018 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT700008 RPS21 ribosomal protein S21 2 2
MIRT701144 PANK1 pantothenate kinase 1 2 2
MIRT712691 NUDT7 nudix hydrolase 7 2 2
MIRT715505 MAZ MYC associated zinc finger protein 2 2
MIRT722509 PTPRC protein tyrosine phosphatase, receptor type C 2 2
MIRT724982 TNS1 tensin 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4464 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4464 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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