miRTarBase - #MIRT101303


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pre-miRNA Information
pre-miRNA hsa-mir-548am   
Genomic Coordinates chrX: 16627012 - 16627085
Description Homo sapiens miR-548am stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548am-5p
Sequence 10| AAAAGUAAUUGCGGUUUUUGCC |31
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 X - 16627074 29233923 MiREDiBase
A-to-I 4 X - 16627073 29233923 MiREDiBase
A-to-I 7 X - 16627070 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs181147953 1 dbSNP
rs1023899452 12 dbSNP
rs1319380894 14 dbSNP
rs768483765 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FAM135A   
Synonyms KIAA1411
Description family with sequence similarity 135 member A
Transcript NM_001105531   
Other Transcripts NM_001162529 , NM_020819   
Expression
Putative miRNA Targets on FAM135A
3'UTR of FAM135A
(miRNA target sites are highlighted)		 
>FAM135A|NM_001105531|3'UTR
   1 TATAAAAGCATTGTTAGCGACTGGACAATTACCTCATTCAACAATGTTTCAAATAATGTATTATATTAAAATGTAGATGC
  81 TGATAAGTTCTAAGAAATATTTATACCTTTTTATATGGAAGATAATTTATATCATCCATGTTTAGTGCTTTTTAAACATC
 161 AACTTTACTTTCTAGGTAATGTGGCTGTGCAATATTTTTTTAATTTTATCTTTTTACTTTTCTATTACTTTTTCATATAT
 241 TTTGCTACCTAAGTATTTCAGTGAAACTTTAAGCCCATACCTGTGTCTGATTGTTTATTATTGGCTTTCCACAATTCTTA
 321 CATCAGACTACATTATATTAGAGACCATTATTGCTAGAATAGCATGGGATTTAAAATTTTCTAATACTGGGGGTATTATT
 401 TAGTTAATTATAAATTTTTCTTTTCACATTTTACTGTGTTTTAACTGGAAATAAAATTATGGCTGCTACAATATATTTTT
 481 TGAAATCAACTTCTGTAGTTCTAAAATACAACTTTATCATACAATCAAACCAGGTAGTTCATATAAAACAGTGTAATACA
 561 AGTTTTCTATAAAGTCATTACTGTTGCTTAAACATATTTCATGCCTATTAAAATATATTTTCTACTGGTGATTTCAACAT
 641 TATTTCTCATACTGACTTTTATTACTGGAAATGTTCCTGTACATGTTGGCAGCAGATAAAGATTTTTGAATGTTTGAATG
 721 CCCTCTGCCTTGATTTGGTTGGAATTTTTGCTAAATTGGTAATGTTGCTTGAACTTTATGACTACATTTTCTTTTAACTT
 801 TTTTCATGGACTTCCTTATATGTACATAATAATTAAATGTTGAAATTTATGAAATACTTTTATGAATTTAGATAATTTTT
 881 AAATATTGTTAAAATTTATTGAACTAAAAAGTAATGTAAATAAAATAATTCATGTTAAAGATGGAACAAAATAATTAACT
 961 TTACATGTTTGGTGATACAGATGCAAATGTTTTTGATATATGGAGATGTTGAGTCTTTTGACTTTACTAAAGGTGCTGAA
1041 TAGCATTAAATTCACTATTTTCCTTTTCTGTTTTACTTGTGAAAATAAAAATGCACTAAGGTTGGGTAGAAGTTCTGTTT
1121 GCACTCACTAATTGTGACAGACAGAGGTTTTTGTAAGTATTTATTGTACAATTGATGCATGTTTATTTTTAGCGTTGTTA
1201 TTGCCTCTGGTGTTAATAAATGAACAAATGGCTATCTGGAGGAACAGCTACAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccguuUUUGGCGUU--AAUGAAAa 5'
               ||||  |||  ||||||| 
Target 5' tttttAAACATCAACTTTACTTTc 3'
 149 - 172 159.00 -5.50
2 
miRNA  3' ccguuuuuggcGUUAAUGAAAa 5'
                     | |||||||| 
Target 5' tttttacttttCTATTACTTTt 3'
 211 - 232 147.00 -5.70
3 
miRNA  3' ccGUUUUUGGCGU--UAAUGAAAa 5'
            |||  : :|||   |||:||| 
Target 5' taCAATTGATGCATGTTTATTTTt 3'
 1167 - 1190 134.00 -8.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26634303 9 COSMIC
COSN30498623 21 COSMIC
COSN7896030 159 COSMIC
COSN31516464 232 COSMIC
COSN31522139 250 COSMIC
COSN31513356 415 COSMIC
COSN31530097 605 COSMIC
COSN31530099 623 COSMIC
COSN31536699 642 COSMIC
COSN31529498 647 COSMIC
COSN30542300 687 COSMIC
COSN30173679 726 COSMIC
COSN31480819 733 COSMIC
COSN29463422 779 COSMIC
COSN19663494 816 COSMIC
COSN26578352 889 COSMIC
COSN31514950 1037 COSMIC
COSN31562165 1037 COSMIC
COSN31528011 1152 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1042335014 3 dbSNP
rs778989385 5 dbSNP
rs16869373 9 dbSNP
rs1239665222 10 dbSNP
rs1238811434 11 dbSNP
rs771683383 19 dbSNP
rs578080585 20 dbSNP
rs1414951551 25 dbSNP
rs746599280 27 dbSNP
rs1159809921 29 dbSNP
rs768374733 35 dbSNP
rs375688242 40 dbSNP
rs762162888 45 dbSNP
rs1013568964 51 dbSNP
rs1403697505 55 dbSNP
rs921124671 65 dbSNP
rs947120064 73 dbSNP
rs978521537 84 dbSNP
rs1025370831 85 dbSNP
rs1438691678 96 dbSNP
rs1269878208 112 dbSNP
rs1380748124 137 dbSNP
rs1180291532 141 dbSNP
rs574699579 144 dbSNP
rs115806559 149 dbSNP
rs1236867817 159 dbSNP
rs1210666305 163 dbSNP
rs1198762057 180 dbSNP
rs201079159 189 dbSNP
rs766345133 192 dbSNP
rs973357190 193 dbSNP
rs1440926741 194 dbSNP
rs1156334936 197 dbSNP
rs1354663119 199 dbSNP
rs992564663 203 dbSNP
rs1311660410 209 dbSNP
rs1244279834 214 dbSNP
rs192485968 215 dbSNP
rs1378842900 224 dbSNP
rs1359442247 225 dbSNP
rs1458072825 228 dbSNP
rs934337628 238 dbSNP
rs62421876 249 dbSNP
rs185685994 252 dbSNP
rs948874370 271 dbSNP
rs943090267 277 dbSNP
rs1386061986 283 dbSNP
rs1044554944 292 dbSNP
rs975871809 298 dbSNP
rs899352702 304 dbSNP
rs188798783 307 dbSNP
rs562531655 315 dbSNP
rs1242348398 319 dbSNP
rs945064298 325 dbSNP
rs1042325272 333 dbSNP
rs1026433492 344 dbSNP
rs903806143 345 dbSNP
rs1321539774 346 dbSNP
rs936474315 360 dbSNP
rs1338034028 363 dbSNP
rs1316454682 369 dbSNP
rs1398883849 376 dbSNP
rs1340544362 378 dbSNP
rs886405171 385 dbSNP
rs1433814166 386 dbSNP
rs1054985821 390 dbSNP
rs1165197833 392 dbSNP
rs1406815355 393 dbSNP
rs1008901344 404 dbSNP
rs1169815721 412 dbSNP
rs1019925096 415 dbSNP
rs1265393401 420 dbSNP
rs1267522361 421 dbSNP
rs1488272111 421 dbSNP
rs1247454659 428 dbSNP
rs1224243570 432 dbSNP
rs1306088163 435 dbSNP
rs965336306 439 dbSNP
rs1219758153 442 dbSNP
rs975760204 445 dbSNP
rs1279535211 447 dbSNP
rs1028110800 450 dbSNP
rs77951043 456 dbSNP
rs79960035 458 dbSNP
rs76523906 460 dbSNP
rs531548678 463 dbSNP
rs1340617990 467 dbSNP
rs1014057307 468 dbSNP
rs1366483532 469 dbSNP
rs1487678325 470 dbSNP
rs1293680970 474 dbSNP
rs1213467795 477 dbSNP
rs968557144 480 dbSNP
rs200670548 483 dbSNP
rs1397826596 486 dbSNP
rs1330642956 494 dbSNP
rs751057653 499 dbSNP
rs369662491 507 dbSNP
rs764322321 509 dbSNP
rs1459495299 513 dbSNP
rs978449356 517 dbSNP
rs1425948171 520 dbSNP
rs193034043 525 dbSNP
rs994165676 527 dbSNP
rs1426178678 532 dbSNP
rs184602947 535 dbSNP
rs1379115530 538 dbSNP
rs924368952 541 dbSNP
rs1423954660 552 dbSNP
rs1199897493 554 dbSNP
rs1166455718 559 dbSNP
rs1261749010 562 dbSNP
rs1207417575 577 dbSNP
rs1311058408 581 dbSNP
rs147026200 603 dbSNP
rs976538 608 dbSNP
rs985695570 618 dbSNP
rs992522291 624 dbSNP
rs559392079 630 dbSNP
rs757569549 633 dbSNP
rs1444439965 652 dbSNP
rs1018370328 657 dbSNP
rs916927696 659 dbSNP
rs965581697 663 dbSNP
rs1330675366 667 dbSNP
rs1438061383 680 dbSNP
rs1380136463 688 dbSNP
rs948977885 693 dbSNP
rs1441853096 699 dbSNP
rs1241863691 720 dbSNP
rs1200333018 724 dbSNP
rs1482668078 740 dbSNP
rs1372690178 742 dbSNP
rs145250091 754 dbSNP
rs746280626 760 dbSNP
rs1315031594 766 dbSNP
rs1351076158 770 dbSNP
rs920751845 774 dbSNP
rs1320171755 775 dbSNP
rs1025065461 778 dbSNP
rs1240640393 785 dbSNP
rs923084412 787 dbSNP
rs750440087 791 dbSNP
rs977778895 807 dbSNP
rs1380062336 810 dbSNP
rs1259079564 814 dbSNP
rs1320490267 821 dbSNP
rs1417872975 826 dbSNP
rs1197297216 827 dbSNP
rs1360131592 829 dbSNP
rs925170283 849 dbSNP
rs1421925072 857 dbSNP
rs930806147 877 dbSNP
rs1183100290 885 dbSNP
rs936547806 886 dbSNP
rs1047803388 897 dbSNP
rs1258805955 899 dbSNP
rs1189453139 915 dbSNP
rs1171000090 917 dbSNP
rs1262051242 918 dbSNP
rs3193656 920 dbSNP
rs949287943 933 dbSNP
rs1009284729 948 dbSNP
rs1463924563 955 dbSNP
rs1244048333 965 dbSNP
rs573282415 968 dbSNP
rs1322270745 973 dbSNP
rs1314695165 974 dbSNP
rs1398258850 978 dbSNP
rs67676955 982 dbSNP
rs900539992 987 dbSNP
rs996767152 990 dbSNP
rs1028203784 995 dbSNP
rs1466583473 996 dbSNP
rs568339502 999 dbSNP
rs1163061217 1000 dbSNP
rs868204072 1001 dbSNP
rs968482563 1002 dbSNP
rs1370735305 1009 dbSNP
rs1000002185 1039 dbSNP
rs1414364244 1040 dbSNP
rs1279152200 1045 dbSNP
rs538546904 1046 dbSNP
rs1342756661 1049 dbSNP
rs1422247950 1058 dbSNP
rs1194018622 1059 dbSNP
rs1031352669 1062 dbSNP
rs955799699 1064 dbSNP
rs1264755488 1069 dbSNP
rs1209027037 1073 dbSNP
rs1488659578 1087 dbSNP
rs1274997296 1096 dbSNP
rs1217196277 1097 dbSNP
rs1317447378 1098 dbSNP
rs993012841 1111 dbSNP
rs748756192 1121 dbSNP
rs970164022 1123 dbSNP
rs1272840276 1124 dbSNP
rs1323097919 1125 dbSNP
rs1313320945 1129 dbSNP
rs543801242 1136 dbSNP
rs888461443 1137 dbSNP
rs1253712360 1142 dbSNP
rs1465558002 1143 dbSNP
rs1422362193 1146 dbSNP
rs1170787316 1153 dbSNP
rs1485098020 1153 dbSNP
rs535423531 1154 dbSNP
rs920850487 1155 dbSNP
rs1264903786 1158 dbSNP
rs930775431 1158 dbSNP
rs879858130 1163 dbSNP
rs1254610384 1176 dbSNP
rs1196737834 1193 dbSNP
rs1185751330 1194 dbSNP
rs1197665686 1194 dbSNP
rs965924872 1195 dbSNP
rs1047938713 1205 dbSNP
rs777626491 1211 dbSNP
rs1425720190 1213 dbSNP
rs998398849 1224 dbSNP
rs1434809707 1225 dbSNP
rs571832161 1226 dbSNP
rs1357494872 1229 dbSNP
rs1446429942 1234 dbSNP
rs534154739 1235 dbSNP
rs1333906431 1238 dbSNP
rs1411171682 1241 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 57579.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccguuuuuggcGUUAAUGAAAa 5'
                     | |||||||| 
Target 5' ------cuuuuCUAUUACUUUu 3'
 		1 - 16
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000418814.2 | 3UTR | CUUUUCUAUUACUUUUUCAUAUAUUUUGCUACCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
184 hsa-miR-548am-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057132 DDIT4 DNA damage inducible transcript 4 2 4
MIRT063379 ETNK1 ethanolamine kinase 1 2 2
MIRT072501 RAB8B RAB8B, member RAS oncogene family 2 2
MIRT082193 ACTN4 actinin alpha 4 2 6
MIRT083043 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT085196 SLC5A3 solute carrier family 5 member 3 2 4
MIRT088913 FOXN2 forkhead box N2 2 4
MIRT089506 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 6
MIRT092047 ABHD5 abhydrolase domain containing 5 2 2
MIRT094692 FEM1C fem-1 homolog C 2 2
MIRT095403 UBE2D2 ubiquitin conjugating enzyme E2 D2 2 2
MIRT096509 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT101303 FAM135A family with sequence similarity 135 member A 2 2
MIRT103366 CBX3 chromobox 3 2 2
MIRT103883 FOXK1 forkhead box K1 2 2
MIRT104343 CLDN12 claudin 12 2 2
MIRT104508 PEG10 paternally expressed 10 2 6
MIRT111808 MPZL1 myelin protein zero like 1 2 2
MIRT177246 BMI1 BMI1 proto-oncogene, polycomb ring finger 2 2
MIRT177281 COMMD3-BMI1 COMMD3-BMI1 readthrough 2 2
MIRT177633 UBE2D1 ubiquitin conjugating enzyme E2 D1 2 6
MIRT178049 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT179109 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 6
MIRT179594 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 6
MIRT195307 LEPROT leptin receptor overlapping transcript 2 2
MIRT203152 BACH1 BTB domain and CNC homolog 1 2 2
MIRT208437 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT214585 SMAD5 SMAD family member 5 2 4
MIRT216112 IL6ST interleukin 6 signal transducer 2 2
MIRT216363 CCNB1 cyclin B1 2 4
MIRT220059 MDFIC MyoD family inhibitor domain containing 2 2
MIRT226737 ANP32B acidic nuclear phosphoprotein 32 family member B 2 4
MIRT227706 TBC1D13 TBC1 domain family member 13 2 2
MIRT230079 SH3BGRL SH3 domain binding glutamate rich protein like 2 2
MIRT248644 HMGN2 high mobility group nucleosomal binding domain 2 2 4
MIRT254799 XRCC6 X-ray repair cross complementing 6 2 6
MIRT264388 YAP1 Yes associated protein 1 2 2
MIRT266982 LRRC55 leucine rich repeat containing 55 2 4
MIRT273957 SPRYD4 SPRY domain containing 4 2 2
MIRT281809 MAP2K1 mitogen-activated protein kinase kinase 1 2 2
MIRT293262 DR1 down-regulator of transcription 1 2 2
MIRT297105 RGPD4 RANBP2-like and GRIP domain containing 4 2 2
MIRT308178 PDE12 phosphodiesterase 12 2 2
MIRT309022 USP53 ubiquitin specific peptidase 53 2 2
MIRT311477 PRRC1 proline rich coiled-coil 1 2 2
MIRT312595 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT328137 ZNF711 zinc finger protein 711 2 2
MIRT329321 FAM53C family with sequence similarity 53 member C 2 2
MIRT334649 NEK7 NIMA related kinase 7 2 2
MIRT340680 THRAP3 thyroid hormone receptor associated protein 3 2 2
MIRT378865 ITGB8 integrin subunit beta 8 2 2
MIRT395798 SPCS3 signal peptidase complex subunit 3 2 2
MIRT405648 WBP4 WW domain binding protein 4 2 4
MIRT408294 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT442112 ZNRF2 zinc and ring finger 2 2 8
MIRT442855 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT443131 VLDLR very low density lipoprotein receptor 2 2
MIRT443162 ZDHHC21 zinc finger DHHC-type containing 21 2 2
MIRT443313 PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 2 2
MIRT445095 ZNF207 zinc finger protein 207 2 2
MIRT445399 PTCHD1 patched domain containing 1 2 4
MIRT447085 MCC mutated in colorectal cancers 2 2
MIRT447315 ZNF562 zinc finger protein 562 2 2
MIRT447528 MRPS5 mitochondrial ribosomal protein S5 2 2
MIRT449526 TM6SF1 transmembrane 6 superfamily member 1 2 2
MIRT449917 C11orf34 placenta expressed transcript 1 1 2
MIRT450566 SHFM1 SEM1, 26S proteasome complex subunit 2 2
MIRT450734 PVRL3 nectin cell adhesion molecule 3 2 2
MIRT454938 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 12
MIRT455907 KIF2C kinesin family member 2C 2 2
MIRT463747 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 8
MIRT471197 PHB2 prohibitin 2 2 2
MIRT472779 MTMR6 myotubularin related protein 6 2 8
MIRT474472 KLHL11 kelch like family member 11 2 8
MIRT476000 GTPBP2 GTP binding protein 2 2 2
MIRT482291 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT485873 ALG9 ALG9, alpha-1,2-mannosyltransferase 2 2
MIRT486207 ERH ERH, mRNA splicing and mitosis factor 2 4
MIRT488624 FAM3C family with sequence similarity 3 member C 2 6
MIRT489999 DDB1 damage specific DNA binding protein 1 2 2
MIRT493491 IPMK inositol polyphosphate multikinase 2 2
MIRT494295 CEP120 centrosomal protein 120 2 2
MIRT498007 ZBTB20 zinc finger and BTB domain containing 20 2 2
MIRT498488 PTBP2 polypyrimidine tract binding protein 2 2 10
MIRT498575 TMEM30B transmembrane protein 30B 2 2
MIRT499882 SVOP SV2 related protein 2 10
MIRT500235 INHBA inhibin beta A subunit 2 10
MIRT500709 TRIM37 tripartite motif containing 37 2 2
MIRT501003 SPPL2A signal peptide peptidase like 2A 2 4
MIRT501038 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 6
MIRT502751 CLIP1 CAP-Gly domain containing linker protein 1 2 8
MIRT502813 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 6
MIRT502903 CDK4 cyclin dependent kinase 4 2 8
MIRT503498 ZNF154 zinc finger protein 154 2 6
MIRT503732 GRM5 glutamate metabotropic receptor 5 2 2
MIRT505152 YOD1 YOD1 deubiquitinase 2 2
MIRT505817 RSBN1 round spermatid basic protein 1 2 8
MIRT505856 POLR1B RNA polymerase I subunit B 2 4
MIRT509299 NPM3 nucleophosmin/nucleoplasmin 3 2 6
MIRT516844 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT520534 TRA2B transformer 2 beta homolog 2 2
MIRT520738 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT525418 SHISA9 shisa family member 9 2 4
MIRT525882 ARL13B ADP ribosylation factor like GTPase 13B 2 2
MIRT526028 RBM4B RNA binding motif protein 4B 2 2
MIRT526099 TMEM41B transmembrane protein 41B 2 2
MIRT527946 FRY FRY microtubule binding protein 2 2
MIRT528833 RAB32 RAB32, member RAS oncogene family 2 2
MIRT531077 SLC9A4 solute carrier family 9 member A4 2 4
MIRT535510 PANX1 pannexin 1 2 2
MIRT536697 IKZF5 IKAROS family zinc finger 5 2 2
MIRT536850 HMBOX1 homeobox containing 1 2 2
MIRT537217 GDE1 glycerophosphodiester phosphodiesterase 1 2 4
MIRT537849 EFNA5 ephrin A5 2 2
MIRT538360 CSE1L chromosome segregation 1 like 2 4
MIRT541257 GPC4 glypican 4 2 2
MIRT543250 PEX7 peroxisomal biogenesis factor 7 2 2
MIRT543465 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT543726 XKR9 XK related 9 2 2
MIRT543922 ESYT1 extended synaptotagmin 1 2 2
MIRT544014 KLRC3 killer cell lectin like receptor C3 2 2
MIRT544085 METTL8 methyltransferase like 8 2 2
MIRT544202 ANGPTL3 angiopoietin like 3 2 2
MIRT544823 ACSM2B acyl-CoA synthetase medium chain family member 2B 2 2
MIRT545061 PRELID1 PRELI domain containing 1 2 2
MIRT545229 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT545304 SPC25 SPC25, NDC80 kinetochore complex component 2 2
MIRT545565 GIMAP4 GTPase, IMAP family member 4 2 2
MIRT546512 SIK1 salt inducible kinase 1 2 2
MIRT546929 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT547690 KPNA1 karyopherin subunit alpha 1 2 4
MIRT547783 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT548702 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 2
MIRT548916 CHEK2 checkpoint kinase 2 2 4
MIRT549972 RPL7L1 ribosomal protein L7 like 1 2 4
MIRT550504 TMEM241 transmembrane protein 241 2 2
MIRT551064 MKLN1 muskelin 1 2 2
MIRT552826 XIAP X-linked inhibitor of apoptosis 2 4
MIRT553160 UBE2H ubiquitin conjugating enzyme E2 H 2 2
MIRT553845 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT554273 SIX4 SIX homeobox 4 2 2
MIRT555796 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 2
MIRT556333 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT556514 LIPA lipase A, lysosomal acid type 2 2
MIRT556708 KLHL28 kelch like family member 28 2 2
MIRT556767 KLF7 Kruppel like factor 7 2 2
MIRT557005 HPRT1 hypoxanthine phosphoribosyltransferase 1 2 2
MIRT557161 HOXA13 homeobox A13 2 2
MIRT557502 GPR27 G protein-coupled receptor 27 2 4
MIRT558117 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT559359 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT560350 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT561314 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT561898 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT561942 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT562950 TNIP2 TNFAIP3 interacting protein 2 2 2
MIRT563306 BBS10 Bardet-Biedl syndrome 10 2 2
MIRT563420 KIF3A kinesin family member 3A 2 2
MIRT563577 KIAA1586 KIAA1586 2 2
MIRT565891 NHS NHS actin remodeling regulator 2 2
MIRT566096 RCC2 regulator of chromosome condensation 2 2 2
MIRT566411 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT567274 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT571483 CCDC80 coiled-coil domain containing 80 2 2
MIRT572954 VDAC2 voltage dependent anion channel 2 2 2
MIRT573643 ZNF724P zinc finger protein 724 2 2
MIRT573732 KHSRP KH-type splicing regulatory protein 2 2
MIRT609103 SMIM15 small integral membrane protein 15 2 6
MIRT617951 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT618394 PRKG2 protein kinase, cGMP-dependent, type II 2 2
MIRT619642 PLEKHG7 pleckstrin homology and RhoGEF domain containing G7 2 2
MIRT623470 KDM5A lysine demethylase 5A 2 2
MIRT629160 CTCFL CCCTC-binding factor like 2 2
MIRT638536 LYRM2 LYR motif containing 2 2 2
MIRT649498 CLDN16 claudin 16 2 2
MIRT683163 MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 2 2
MIRT691675 SLC43A3 solute carrier family 43 member 3 2 2
MIRT693216 MKI67 marker of proliferation Ki-67 2 2
MIRT695349 AQP3 aquaporin 3 (Gill blood group) 2 2
MIRT701038 PCGF5 polycomb group ring finger 5 2 2
MIRT708768 RYBP RING1 and YY1 binding protein 2 2
MIRT717573 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT719301 SETD7 SET domain containing lysine methyltransferase 7 2 2
MIRT725187 SDAD1 SDA1 domain containing 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-548am-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, HCC827)
hsa-miR-548am-5p Gefitinib 123631 NSC715055 approved resistant High Non-Small Cell Lung Cancer cell line (A549, HCC827)
hsa-miR-548am-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-548am-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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