miRTarBase - #MIRT103367


—
pre-miRNA Information
pre-miRNA hsa-mir-3973   
Genomic Coordinates chr11: 36010098 - 36010204
Description Homo sapiens miR-3973 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3973
Sequence 84| ACAAAGUACAGCAUUAGCCUUAG |106
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs770990564 3 dbSNP
rs1265409247 6 dbSNP
rs776720932 7 dbSNP
rs1303596672 18 dbSNP
rs183016698 23 dbSNP
Putative Targets

Gene Information
Gene Symbol CBX3   
Synonyms HECH, HP1-GAMMA, HP1Hs-gamma
Description chromobox 3
Transcript NM_007276   
Other Transcripts NM_016587   
Expression
Putative miRNA Targets on CBX3
3'UTR of CBX3
(miRNA target sites are highlighted)		 
>CBX3|NM_007276|3'UTR
   1 TTGTTCACATTGTTCTTTTATATATATTTATATATATATATAAAAATTGGGTCTTAGATTTTGATTTACTAGTGTGACAA
  81 AATAACTACATCCTAATGAAAATCAAGTTTGATATGTTTGTTTTGAAAGTAGCGTTGGAAGAGTTGTTGGGGGTTTTTTG
 161 CATCCATAGCACTGGTTACTTTGAACAAATAAATAAAAGCTTTCTGTAGTTGCTTCCTTTATCAGAAAAGAACATTTGAT
 241 ACCATGGTATATCATTTCCTCTTCATTAAAGAACAGCTTTTCTAAATGTTGGGGGAAATGTCCATAGTCATTACTCAGTC
 321 AAAACTTGTGTTCTCATGAGCCTAAGGACCATTCTAGATTTATTACGTGTTTTTTGTGTGTGTGTGTGTGTGTGTGTGTG
 401 TGTGTATCCATAAAATGCATATGTAAATTTTTTTTTGTTTTTAAGCATTCACCCAAACAAAAAAATCACAGGTAAACCCA
 481 TGTTTCTGAGATGCCATTATTCCAAGCAAAATAAGAGATAATCCCTTCAAGTTAAATTGAAAATTTTCCTGAAACCATAC
 561 ATTTCAAGTGAAATAAGTAATTCTAGATAGGACAATTTAAATTGGATAATTTTAAAGTGTCTATAATTGCAGTGGTTTAT
 641 TTGCAAAATTCCTAAAAGGAAAAATTTTATCACTGCCATCACAGCAGGTTTCCTCATCCAGATGAGGAAACTAGACAAAT
 721 GCTAGTGTGTTTTAACTAGCTAAACAAAACTAAGTTAAATGAACATTTAAAAGTTTCCCTAGCGGGCCATTCCTTAGCAA
 801 AATGTTGGAATCCCTGTTGCTACATTGACTAAAAGGTCATGATGAATGGAATATGTAAGACTTGGCTCATAGAAACCTAA
 881 TCAGATGGTTAGAGGTGTTGGCAGTTTAGGACCTGCTGTCATAAATGTGTGAACAACCTTTTGTAACCTAACCTATTGAC
 961 CTGCATGTTTTTTCTTTACCCCAATTCATTACATGGAGGCTCAATCTTGAGTTTGCTTTACTGGTTCAGCAAAAGCCAGG
1041 AAGAACAACTTTGTAGTAATCAAAATGTTATCCAACTGTATATTGTTTACTTTATTGTAAATACTGGTGAACAGTGGTTA
1121 ATAAATAGTTTTATATTCCTTTATGCAATTATTAGACTTTTTTCTTTATTTGATATGCCTTTACAGTAGAAATAGAAATG
1201 CCCACACTCATTGGATTATCTTTGTTTATAAGTTAGATGATACCAGTAAGGCATTACAGTACATATCCTAGATCTTTTGA
1281 GCTTACGAGTTTTAAACTTGAATATGTATTTCCACAGGAATGTTTCCACAGTTGGGAAATAAAAGTTTCATGTGATGCCT
1361 AGGGTCAATTGTCTCATTAAAATGAGGTTTTAAATTCTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauuccgAUUACGAC--AUGAAACa 5'
                 ||:  |||  ||||||| 
Target 5' gcatccaTAGCACTGGTTACTTTGa 3'
 160 - 184 150.00 -8.00
2 
miRNA  3' gauuccgAUUACGACAUGAAAca 5'
                 || ||:| ||||||  
Target 5' aactgtaTATTGTT-TACTTTat 3'
 1074 - 1095 135.00 -7.09
3 
miRNA  3' gaUUCCGA-UUACGAC----AUGAAAca 5'
            :||||| ||| :||    |:||||  
Target 5' tgGAGGCTCAATCTTGAGTTTGCTTTac 3'
 994 - 1021 131.00 -10.34
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31547870 15 COSMIC
COSN8313160 16 COSMIC
COSN30111102 24 COSMIC
COSN31547062 29 COSMIC
COSN30172291 126 COSMIC
COSN17999689 375 COSMIC
COSN20103972 375 COSMIC
COSN15663217 377 COSMIC
COSN32065599 377 COSMIC
COSN7976031 379 COSMIC
COSN32057439 381 COSMIC
COSN20515797 385 COSMIC
COSN20506707 387 COSMIC
COSN20103973 403 COSMIC
COSN32062223 406 COSMIC
COSN20091545 784 COSMIC
COSN31584414 969 COSMIC
COSN31579765 974 COSMIC
COSN31596203 1000 COSMIC
COSN25027399 1081 COSMIC
COSN15663144 1108 COSMIC
COSN26560789 1139 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs753824971 3 dbSNP
rs754927630 8 dbSNP
rs778244272 10 dbSNP
rs747695069 11 dbSNP
rs1219228169 12 dbSNP
rs756775029 13 dbSNP
rs771563880 13 dbSNP
rs1212252044 14 dbSNP
rs767121792 14 dbSNP
rs750059523 15 dbSNP
rs9768418 16 dbSNP
rs1376009077 17 dbSNP
rs746229930 17 dbSNP
rs770320418 19 dbSNP
rs1382478280 20 dbSNP
rs1233306171 21 dbSNP
rs1463948520 21 dbSNP
rs776117134 24 dbSNP
rs569606982 27 dbSNP
rs1169854946 28 dbSNP
rs749825060 29 dbSNP
rs756466015 29 dbSNP
rs780514476 29 dbSNP
rs769212843 31 dbSNP
rs761570988 32 dbSNP
rs191976883 33 dbSNP
rs1174365849 35 dbSNP
rs558509108 40 dbSNP
rs762011516 41 dbSNP
rs1250656691 42 dbSNP
rs755610639 42 dbSNP
rs1201832732 43 dbSNP
rs1491030362 43 dbSNP
rs145395285 44 dbSNP
rs1292121731 48 dbSNP
rs773527822 50 dbSNP
rs1204817390 53 dbSNP
rs1460687807 54 dbSNP
rs1374736395 65 dbSNP
rs1209186739 69 dbSNP
rs1249498829 70 dbSNP
rs541141900 73 dbSNP
rs554318585 76 dbSNP
rs1424237050 84 dbSNP
rs574290972 87 dbSNP
rs767813762 88 dbSNP
rs1484650128 89 dbSNP
rs184267440 93 dbSNP
rs1425198851 94 dbSNP
rs1419385281 105 dbSNP
rs1434432440 106 dbSNP
rs1179172603 108 dbSNP
rs1490715797 111 dbSNP
rs1221340109 112 dbSNP
rs1268935110 112 dbSNP
rs564728658 116 dbSNP
rs1262082771 120 dbSNP
rs961143819 127 dbSNP
rs1317835612 128 dbSNP
rs972930365 134 dbSNP
rs575256913 135 dbSNP
rs376832373 140 dbSNP
rs1404371534 147 dbSNP
rs563219634 153 dbSNP
rs1290799063 154 dbSNP
rs1321726459 154 dbSNP
rs1363003766 155 dbSNP
rs1347325491 161 dbSNP
rs1156902023 162 dbSNP
rs1428828400 172 dbSNP
rs1481362982 174 dbSNP
rs1429846466 175 dbSNP
rs1198100961 177 dbSNP
rs764324873 178 dbSNP
rs1489599028 181 dbSNP
rs1263424657 182 dbSNP
rs1288538830 185 dbSNP
rs1368355040 187 dbSNP
rs917423522 191 dbSNP
rs971975204 192 dbSNP
rs532023444 197 dbSNP
rs1326325334 203 dbSNP
rs535298845 203 dbSNP
rs1223003012 204 dbSNP
rs1329408629 212 dbSNP
rs1298080506 214 dbSNP
rs1382955661 218 dbSNP
rs754233464 221 dbSNP
rs1228934963 223 dbSNP
rs1286016521 224 dbSNP
rs1175546572 227 dbSNP
rs1476788693 229 dbSNP
rs189467571 231 dbSNP
rs1374263224 235 dbSNP
rs1193515569 242 dbSNP
rs1427581202 245 dbSNP
rs1259183298 246 dbSNP
rs1207226964 247 dbSNP
rs1314932992 248 dbSNP
rs1264373818 255 dbSNP
rs1214585253 256 dbSNP
rs1343006086 259 dbSNP
rs1253123713 261 dbSNP
rs1246968603 262 dbSNP
rs1326101508 277 dbSNP
rs1295591023 278 dbSNP
rs1490691875 283 dbSNP
rs1383241059 289 dbSNP
rs1336076933 291 dbSNP
rs1412666295 291 dbSNP
rs1398484213 293 dbSNP
rs1168025855 295 dbSNP
rs1460987343 296 dbSNP
rs1196731044 297 dbSNP
rs1387955005 302 dbSNP
rs1185039848 305 dbSNP
rs1446896570 307 dbSNP
rs1267379887 311 dbSNP
rs1441213180 312 dbSNP
rs1253232091 313 dbSNP
rs1480360279 317 dbSNP
rs1338759551 318 dbSNP
rs1160576355 326 dbSNP
rs1248439562 327 dbSNP
rs1359949927 334 dbSNP
rs1410563726 335 dbSNP
rs182369741 336 dbSNP
rs1158624022 338 dbSNP
rs9768454 339 dbSNP
rs1390378526 345 dbSNP
rs1368163740 351 dbSNP
rs1406838458 353 dbSNP
rs1301299166 359 dbSNP
rs1424873952 361 dbSNP
rs1384162727 363 dbSNP
rs1163070918 364 dbSNP
rs1344980496 367 dbSNP
rs878949545 368 dbSNP
rs1183146485 370 dbSNP
rs1224753695 370 dbSNP
rs1491418688 370 dbSNP
rs751042522 370 dbSNP
rs766069620 370 dbSNP
rs1226413152 371 dbSNP
rs777106956 371 dbSNP
rs778832605 371 dbSNP
rs1280138419 372 dbSNP
rs1159693298 373 dbSNP
rs1238207099 373 dbSNP
rs1321106770 373 dbSNP
rs1339185486 373 dbSNP
rs1410347358 373 dbSNP
rs1472564477 373 dbSNP
rs1480772881 373 dbSNP
rs150158222 373 dbSNP
rs150882395 373 dbSNP
rs56362406 373 dbSNP
rs749651686 373 dbSNP
rs760099662 373 dbSNP
rs1246408082 374 dbSNP
rs770176528 374 dbSNP
rs780563058 374 dbSNP
rs78265643 374 dbSNP
rs1204214660 375 dbSNP
rs1215774949 375 dbSNP
rs1275867758 375 dbSNP
rs1296347063 375 dbSNP
rs1362232253 375 dbSNP
rs199895382 375 dbSNP
rs200992022 375 dbSNP
rs202216295 375 dbSNP
rs70943279 375 dbSNP
rs878948520 375 dbSNP
rs879214653 375 dbSNP
rs9769357 375 dbSNP
rs1339319598 376 dbSNP
rs1363464792 376 dbSNP
rs767646263 376 dbSNP
rs769230185 376 dbSNP
rs775742547 376 dbSNP
rs12532361 377 dbSNP
rs756326250 378 dbSNP
rs761490406 378 dbSNP
rs1174077091 379 dbSNP
rs200128779 379 dbSNP
rs1168181855 381 dbSNP
rs775186858 381 dbSNP
rs1281244434 382 dbSNP
rs879723637 383 dbSNP
rs1223052298 384 dbSNP
rs201652043 385 dbSNP
rs1361242873 386 dbSNP
rs201093455 387 dbSNP
rs1273556993 388 dbSNP
rs1290329171 389 dbSNP
rs1483112740 390 dbSNP
rs1183121201 396 dbSNP
rs1317643926 397 dbSNP
rs1235147459 398 dbSNP
rs1396930761 399 dbSNP
rs1468910139 403 dbSNP
rs1177055812 405 dbSNP
rs1301540970 405 dbSNP
rs1342897404 407 dbSNP
rs1414982325 408 dbSNP
rs1426721283 411 dbSNP
rs1428040798 412 dbSNP
rs1387260534 413 dbSNP
rs1163986386 414 dbSNP
rs1161928875 416 dbSNP
rs1411611996 417 dbSNP
rs1178876309 418 dbSNP
rs547874016 420 dbSNP
rs1480698112 422 dbSNP
rs567613645 423 dbSNP
rs1364994212 427 dbSNP
rs1202350289 428 dbSNP
rs1250400018 428 dbSNP
rs1490748690 428 dbSNP
rs1430532838 429 dbSNP
rs1246000677 430 dbSNP
rs935964334 431 dbSNP
rs1265570698 432 dbSNP
rs1330786856 432 dbSNP
rs111871239 438 dbSNP
rs1054439798 442 dbSNP
rs1324851755 443 dbSNP
rs1351235964 443 dbSNP
rs1408034295 451 dbSNP
rs1367698907 454 dbSNP
rs543917453 455 dbSNP
rs1441205675 459 dbSNP
rs1457278873 459 dbSNP
rs1347874056 460 dbSNP
rs1161268986 462 dbSNP
rs549563127 463 dbSNP
rs1284507590 464 dbSNP
rs1384748575 466 dbSNP
rs1276520715 467 dbSNP
rs760292664 470 dbSNP
rs1243265948 472 dbSNP
rs1208863818 475 dbSNP
rs563510621 476 dbSNP
rs1342220289 477 dbSNP
rs1264027379 479 dbSNP
rs1218326348 489 dbSNP
rs569648461 490 dbSNP
rs1275714557 495 dbSNP
rs184550155 496 dbSNP
rs1226713449 497 dbSNP
rs1204457736 500 dbSNP
rs913250934 507 dbSNP
rs1302290994 509 dbSNP
rs1386401144 510 dbSNP
rs1365692237 513 dbSNP
rs1290440828 514 dbSNP
rs558543587 520 dbSNP
rs767915869 525 dbSNP
rs1446855683 536 dbSNP
rs1156845483 537 dbSNP
rs1470710171 540 dbSNP
rs1181946327 552 dbSNP
rs10156063 555 dbSNP
rs1188662758 559 dbSNP
rs1263357333 559 dbSNP
rs1475776136 560 dbSNP
rs543900752 576 dbSNP
rs1207350048 581 dbSNP
rs1325811284 582 dbSNP
rs1394429403 588 dbSNP
rs1409246579 590 dbSNP
rs946143970 591 dbSNP
rs1334777551 594 dbSNP
rs1329563767 595 dbSNP
rs1407984122 596 dbSNP
rs1435621117 597 dbSNP
rs1364193130 598 dbSNP
rs1318508550 599 dbSNP
rs1450239220 603 dbSNP
rs565672843 607 dbSNP
rs1365554135 608 dbSNP
rs1171519331 610 dbSNP
rs1464047934 614 dbSNP
rs1374494568 617 dbSNP
rs1168832886 618 dbSNP
rs1229158984 620 dbSNP
rs1267839740 622 dbSNP
rs1450523670 622 dbSNP
rs1040898134 627 dbSNP
rs3735554 630 dbSNP
rs1257390657 631 dbSNP
rs1338205489 631 dbSNP
rs1214454412 636 dbSNP
rs1342950596 640 dbSNP
rs1264350395 644 dbSNP
rs1462919751 651 dbSNP
rs1202236495 653 dbSNP
rs1242759766 655 dbSNP
rs1447733836 658 dbSNP
rs1195623144 660 dbSNP
rs1341260610 666 dbSNP
rs900962846 667 dbSNP
rs1247848424 668 dbSNP
rs534280361 670 dbSNP
rs753810913 674 dbSNP
rs1333364910 677 dbSNP
rs948205494 678 dbSNP
rs997980631 679 dbSNP
rs1049601389 683 dbSNP
rs1308309377 687 dbSNP
rs1428728923 688 dbSNP
rs189258793 689 dbSNP
rs1167101133 690 dbSNP
rs1177036941 694 dbSNP
rs1187460755 698 dbSNP
rs1431427921 698 dbSNP
rs1254044326 701 dbSNP
rs1468030764 702 dbSNP
rs1205900909 703 dbSNP
rs1482870644 705 dbSNP
rs1272669264 710 dbSNP
rs889683873 711 dbSNP
rs1283566992 712 dbSNP
rs1005455099 713 dbSNP
rs1288460560 719 dbSNP
rs1408615465 720 dbSNP
rs1368324707 721 dbSNP
rs1175359146 723 dbSNP
rs1016594589 726 dbSNP
rs574579244 727 dbSNP
rs961376049 730 dbSNP
rs1472110452 732 dbSNP
rs1414784842 739 dbSNP
rs1182995678 746 dbSNP
rs1315821652 747 dbSNP
rs1249963324 751 dbSNP
rs1325320176 760 dbSNP
rs1452015198 761 dbSNP
rs1288905115 764 dbSNP
rs1436635936 765 dbSNP
rs1284470063 769 dbSNP
rs1207801458 771 dbSNP
rs1326364928 774 dbSNP
rs1331136833 780 dbSNP
rs1227303893 782 dbSNP
rs543273759 784 dbSNP
rs374505442 785 dbSNP
rs765035386 789 dbSNP
rs1403890742 790 dbSNP
rs1391487721 791 dbSNP
rs1160537183 793 dbSNP
rs1456816051 794 dbSNP
rs1409821752 797 dbSNP
rs993893400 799 dbSNP
rs1478496628 804 dbSNP
rs1246276019 805 dbSNP
rs1207082962 810 dbSNP
rs1196495357 811 dbSNP
rs1259969284 813 dbSNP
rs1024483282 814 dbSNP
rs576678371 817 dbSNP
rs1446483121 822 dbSNP
rs971562271 825 dbSNP
rs1343861881 829 dbSNP
rs1200308331 830 dbSNP
rs1271142941 831 dbSNP
rs1367789700 832 dbSNP
rs1321862730 840 dbSNP
rs11554894 842 dbSNP
rs1175643301 844 dbSNP
rs1178328798 845 dbSNP
rs1424794269 848 dbSNP
rs1364119864 854 dbSNP
rs1451139568 856 dbSNP
rs1187648416 861 dbSNP
rs980285796 862 dbSNP
rs1455191451 864 dbSNP
rs1210225843 866 dbSNP
rs549197600 867 dbSNP
rs1156425757 870 dbSNP
rs1441323832 871 dbSNP
rs927467860 872 dbSNP
rs1230131810 873 dbSNP
rs1383866628 878 dbSNP
rs1342374521 880 dbSNP
rs1228039459 881 dbSNP
rs1424742112 881 dbSNP
rs1360505166 889 dbSNP
rs1305094515 891 dbSNP
rs1304364870 895 dbSNP
rs1343114647 896 dbSNP
rs1332503129 898 dbSNP
rs957594392 906 dbSNP
rs1390979011 908 dbSNP
rs1167734843 914 dbSNP
rs1447376864 922 dbSNP
rs1283245763 923 dbSNP
rs1182370788 926 dbSNP
rs1482667092 928 dbSNP
rs1336700220 931 dbSNP
rs990434915 932 dbSNP
rs1273391431 934 dbSNP
rs754532052 934 dbSNP
rs1204963789 939 dbSNP
rs913229770 939 dbSNP
rs752431269 943 dbSNP
rs559982933 945 dbSNP
rs1229367954 946 dbSNP
rs1291553821 948 dbSNP
rs1379024736 948 dbSNP
rs1411667954 949 dbSNP
rs1371419393 951 dbSNP
rs1307643724 953 dbSNP
rs1350140187 956 dbSNP
rs780776847 960 dbSNP
rs1040423264 961 dbSNP
rs375726042 962 dbSNP
rs1293979463 964 dbSNP
rs1250700433 968 dbSNP
rs747720619 970 dbSNP
rs7186 975 dbSNP
rs565392435 976 dbSNP
rs572413925 985 dbSNP
rs1179480147 986 dbSNP
rs1271761406 988 dbSNP
rs1230375221 991 dbSNP
rs541058585 993 dbSNP
rs1288006925 995 dbSNP
rs1389868812 996 dbSNP
rs1369949795 997 dbSNP
rs1444806793 1002 dbSNP
rs1392270685 1003 dbSNP
rs1049538305 1004 dbSNP
rs561094204 1005 dbSNP
rs1457346480 1009 dbSNP
rs1165110923 1012 dbSNP
rs1410549429 1025 dbSNP
rs1363125483 1028 dbSNP
rs1423501076 1029 dbSNP
rs1267533268 1038 dbSNP
rs1293440563 1046 dbSNP
rs1192157322 1047 dbSNP
rs78619479 1049 dbSNP
rs1397911964 1053 dbSNP
rs1251753378 1055 dbSNP
rs1393648039 1057 dbSNP
rs1305231439 1058 dbSNP
rs1329984724 1060 dbSNP
rs530117129 1061 dbSNP
rs1236885941 1062 dbSNP
rs766771132 1072 dbSNP
rs1302227440 1073 dbSNP
rs1386068509 1077 dbSNP
rs1246934206 1079 dbSNP
rs1435749814 1083 dbSNP
rs546499173 1086 dbSNP
rs1357344089 1091 dbSNP
rs1467082870 1092 dbSNP
rs1377906824 1094 dbSNP
rs1174910788 1095 dbSNP
rs1454140295 1096 dbSNP
rs1393636603 1097 dbSNP
rs1190857188 1101 dbSNP
rs144437057 1105 dbSNP
rs377589440 1105 dbSNP
rs868458558 1113 dbSNP
rs1251814157 1115 dbSNP
rs1481538218 1116 dbSNP
rs766588991 1120 dbSNP
rs1256848340 1121 dbSNP
rs1232772248 1122 dbSNP
rs754181630 1130 dbSNP
rs13247806 1132 dbSNP
rs889651306 1134 dbSNP
rs28407029 1139 dbSNP
rs1401910545 1142 dbSNP
rs1318622552 1144 dbSNP
rs142267744 1144 dbSNP
rs1223505445 1146 dbSNP
rs1254763799 1146 dbSNP
rs563164402 1147 dbSNP
rs1443471624 1148 dbSNP
rs1170449140 1149 dbSNP
rs373262978 1150 dbSNP
rs1371951062 1153 dbSNP
rs1170890403 1154 dbSNP
rs1374304784 1156 dbSNP
rs181300726 1158 dbSNP
rs1463935250 1160 dbSNP
rs1425681809 1161 dbSNP
rs1256975949 1165 dbSNP
rs994251777 1165 dbSNP
rs1484818331 1168 dbSNP
rs1296990660 1173 dbSNP
rs1399985382 1174 dbSNP
rs1276969942 1175 dbSNP
rs893896515 1177 dbSNP
rs369134863 1178 dbSNP
rs1341195856 1179 dbSNP
rs1268386074 1180 dbSNP
rs945407009 1185 dbSNP
rs1246871424 1189 dbSNP
rs1024036095 1191 dbSNP
rs1042589781 1194 dbSNP
rs1001313421 1203 dbSNP
rs1372082940 1214 dbSNP
rs1308256075 1215 dbSNP
rs1034507887 1216 dbSNP
rs1296319120 1219 dbSNP
rs1166461938 1221 dbSNP
rs1459923961 1221 dbSNP
rs1309361027 1223 dbSNP
rs1369482299 1229 dbSNP
rs1187332841 1236 dbSNP
rs111891412 1241 dbSNP
rs115829318 1242 dbSNP
rs547853175 1244 dbSNP
rs967373176 1245 dbSNP
rs749155788 1254 dbSNP
rs1012580571 1256 dbSNP
rs1356981155 1256 dbSNP
rs552155077 1258 dbSNP
rs923328061 1263 dbSNP
rs1230994931 1266 dbSNP
rs1186762461 1273 dbSNP
rs1288639116 1278 dbSNP
rs1026570331 1279 dbSNP
rs568198570 1287 dbSNP
rs1388832647 1289 dbSNP
rs1392157752 1296 dbSNP
rs1164834269 1299 dbSNP
rs1459982731 1304 dbSNP
rs537161081 1305 dbSNP
rs911018000 1306 dbSNP
rs1469847870 1307 dbSNP
rs941206348 1309 dbSNP
rs1423618600 1321 dbSNP
rs1038261658 1322 dbSNP
rs897083688 1323 dbSNP
rs1268243359 1327 dbSNP
rs1178948221 1332 dbSNP
rs1222637013 1344 dbSNP
rs1404382280 1346 dbSNP
rs982467965 1349 dbSNP
rs1348112145 1359 dbSNP
rs774467142 1362 dbSNP
rs929933938 1367 dbSNP
rs906901315 1369 dbSNP
rs1289704545 1370 dbSNP
rs1364137289 1372 dbSNP
rs1001282371 1375 dbSNP
rs1400133050 1376 dbSNP
rs1406142426 1382 dbSNP
rs1034102549 1385 dbSNP
rs1478261936 1387 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760632. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_C ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000337620.4 | 3UTR | CAUCCAUAGCACUGGUUACUUUGAACAAAUAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000337620.4 | 3UTR | UUUUUUGCAUCCAUAGCACUGGUUACUUUGAACAAAUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000337620.4 | 3UTR | CAUCCAUAGCACUGGUUACUUUGAACAAAUAAAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
136 hsa-miR-3973 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT060560 CCND1 cyclin D1 2 2
MIRT060977 LAMC1 laminin subunit gamma 1 2 2
MIRT067617 TMPO thymopoietin 2 2
MIRT072503 RAB8B RAB8B, member RAS oncogene family 2 2
MIRT092048 ABHD5 abhydrolase domain containing 5 2 6
MIRT093449 MSMO1 methylsterol monooxygenase 1 2 2
MIRT093538 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT095404 UBE2D2 ubiquitin conjugating enzyme E2 D2 2 2
MIRT103367 CBX3 chromobox 3 2 2
MIRT110447 PLEKHA1 pleckstrin homology domain containing A1 2 10
MIRT161196 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT161903 FXR1 FMR1 autosomal homolog 1 2 2
MIRT192775 B2M beta-2-microglobulin 2 2
MIRT195782 ATMIN ATM interactor 2 6
MIRT228194 BNC2 basonuclin 2 2 2
MIRT237882 WHSC1 nuclear receptor binding SET domain protein 2 2 4
MIRT249021 PABPC3 poly(A) binding protein cytoplasmic 3 2 8
MIRT273958 SPRYD4 SPRY domain containing 4 2 2
MIRT309023 USP53 ubiquitin specific peptidase 53 2 2
MIRT312596 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT315536 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT319305 CAV1 caveolin 1 2 2
MIRT324436 TBC1D13 TBC1 domain family member 13 2 2
MIRT325710 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT340681 THRAP3 thyroid hormone receptor associated protein 3 2 2
MIRT404628 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT443473 ACPP acid phosphatase, prostate 2 2
MIRT443545 ZNRF2 zinc and ring finger 2 2 2
MIRT446290 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT447066 MCC mutated in colorectal cancers 2 2
MIRT447365 RASA2 RAS p21 protein activator 2 2 2
MIRT450079 ZNF354C zinc finger protein 354C 2 2
MIRT454270 PSMA1 proteasome subunit alpha 1 2 2
MIRT456032 CRYZ crystallin zeta 2 8
MIRT462069 CCDC77 coiled-coil domain containing 77 2 4
MIRT466379 TGOLN2 trans-golgi network protein 2 2 4
MIRT470352 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT471866 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT474453 KLHL11 kelch like family member 11 2 8
MIRT476188 GOLGA8A golgin A8 family member A 2 10
MIRT476645 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT481544 ARL10 ADP ribosylation factor like GTPase 10 2 10
MIRT481791 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT482527 ACTB actin beta 2 4
MIRT485570 FOXQ1 forkhead box Q1 2 2
MIRT486011 LPAR2 lysophosphatidic acid receptor 2 2 2
MIRT495182 MUC20 mucin 20, cell surface associated 2 2
MIRT496047 MORC1 MORC family CW-type zinc finger 1 2 2
MIRT497114 JRKL JRK like 2 2
MIRT497494 RGS17 regulator of G protein signaling 17 2 2
MIRT497752 OXGR1 oxoglutarate receptor 1 2 2
MIRT500217 INHBA inhibin beta A subunit 2 10
MIRT501079 SMAD7 SMAD family member 7 2 8
MIRT501453 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 8
MIRT502793 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 6
MIRT502879 CDK4 cyclin dependent kinase 4 2 8
MIRT505796 RSBN1 round spermatid basic protein 1 2 8
MIRT506345 NUP54 nucleoporin 54 2 6
MIRT507415 ELK4 ELK4, ETS transcription factor 2 4
MIRT509272 NPM3 nucleophosmin/nucleoplasmin 3 2 6
MIRT514931 TRIM73 tripartite motif containing 73 2 2
MIRT515441 TRIM74 tripartite motif containing 74 2 2
MIRT516026 A1CF APOBEC1 complementation factor 2 2
MIRT517375 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT527925 FRY FRY microtubule binding protein 2 2
MIRT529611 H1F0 H1 histone family member 0 2 2
MIRT530606 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT530970 EXO5 exonuclease 5 2 4
MIRT532108 RRP8 ribosomal RNA processing 8 2 2
MIRT533006 ZFHX3 zinc finger homeobox 3 2 4
MIRT533103 YOD1 YOD1 deubiquitinase 2 2
MIRT533231 VLDLR very low density lipoprotein receptor 2 2
MIRT534073 SRPK1 SRSF protein kinase 1 2 2
MIRT534457 SCML2 Scm polycomb group protein like 2 2 4
MIRT536678 IKZF5 IKAROS family zinc finger 5 2 2
MIRT538224 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT539218 ANP32E acidic nuclear phosphoprotein 32 family member E 2 4
MIRT541157 PABPC1 poly(A) binding protein cytoplasmic 1 2 4
MIRT552682 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT554457 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT556688 KLHL28 kelch like family member 28 2 2
MIRT558162 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT558195 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT558752 CHERP calcium homeostasis endoplasmic reticulum protein 2 2
MIRT561871 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT567443 GNG12 G protein subunit gamma 12 2 2
MIRT568399 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT569178 DMD dystrophin 2 2
MIRT571465 CCDC80 coiled-coil domain containing 80 2 2
MIRT575987 Fem1a feminization 1 homolog a (C. elegans) 2 5
MIRT606844 FEM1A fem-1 homolog A 2 7
MIRT615813 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT619491 QSOX2 quiescin sulfhydryl oxidase 2 2 2
MIRT624354 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT625979 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT628564 MELK maternal embryonic leucine zipper kinase 2 2
MIRT631329 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT639435 PKP1 plakophilin 1 2 2
MIRT640366 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT640701 SKI SKI proto-oncogene 2 2
MIRT640718 CEP68 centrosomal protein 68 2 2
MIRT641217 TRIB1 tribbles pseudokinase 1 2 4
MIRT642271 SMIM17 small integral membrane protein 17 2 2
MIRT644011 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT645146 CUBN cubilin 2 2
MIRT653158 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT654475 RANBP2 RAN binding protein 2 2 2
MIRT656177 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT658719 ELMOD2 ELMO domain containing 2 2 2
MIRT658857 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT663935 ZNF554 zinc finger protein 554 2 2
MIRT664901 EMC7 ER membrane protein complex subunit 7 2 2
MIRT668801 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT673514 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT683192 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT684049 FOLR1 folate receptor 1 2 2
MIRT685543 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 2
MIRT690365 RPL37A ribosomal protein L37a 2 2
MIRT691612 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT691651 SLC43A3 solute carrier family 43 member 3 2 2
MIRT694108 ZNF446 zinc finger protein 446 2 2
MIRT695618 VBP1 VHL binding protein 1 2 2
MIRT695925 ZNF174 zinc finger protein 174 2 2
MIRT696445 SUGP1 SURP and G-patch domain containing 1 2 2
MIRT697983 TSPAN6 tetraspanin 6 2 2
MIRT699769 SEMA4D semaphorin 4D 2 2
MIRT702946 HIPK3 homeodomain interacting protein kinase 3 2 2
MIRT703385 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT704011 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT704182 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT704446 CTNNB1 catenin beta 1 2 2
MIRT708514 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT713068 ENTHD1 ENTH domain containing 1 2 2
MIRT715799 TBL3 transducin beta like 3 2 2
MIRT716441 RPS24 ribosomal protein S24 2 2
MIRT719421 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3973 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-3973 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-3973 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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