miRTarBase - #MIRT104334


—
pre-miRNA Information
pre-miRNA hsa-mir-548w   
Genomic Coordinates chr16: 26025237 - 26025310
Description Homo sapiens miR-548w stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548w
Sequence 10| AAAAGUAACUGCGGUUUUUGCCU |32
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 16 + 26025249 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs918935898 1 dbSNP
rs573018690 4 dbSNP
rs1355338018 5 dbSNP
rs1232952112 7 dbSNP
rs768527810 12 dbSNP
rs1331351492 13 dbSNP
rs925963272 14 dbSNP
rs1299975801 16 dbSNP
rs1247960808 17 dbSNP
rs1217191628 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CLDN12   
Synonyms -
Description claudin 12
Transcript NM_001185072   
Other Transcripts NM_001185073 , NM_012129   
Expression
Putative miRNA Targets on CLDN12
3'UTR of CLDN12
(miRNA target sites are highlighted)		 
>CLDN12|NM_001185072|3'UTR
   1 TGGGGAAATAGTTAATTGTTAAAGAAAACTTCTTGTAGCCTCACATTCCCCTTGTGCAAAGAGCTCTTTTGGACCTACAT
  81 ACATTTTCCTTTGTTTTTGACCAATCAATGAAGCCAAATTTATATGTCCTAGTAGAATGAAGTGCTGCTAGTTTTTATGA
 161 GAAGTATATTATATTAAATGTGAATTTTTTAAATTTTGCTTCTTATACTGGAAGGAATTTTAGCCTTCATATTGATATCT
 241 AATTAATTATTTAAGTGGAAGAGGCCTGCATCACAATTGAGGTAATGTAGAGCAACATGTTAAAGAATGATGGTTAGCAG
 321 AAGCTGTTGTATACAATCTTCATGAAAATTTCAGTGTGTATTTTTCTTTTTCTATAATACCTTTAACTGCAAAGAAAAGG
 401 CAGTTTCAAATATAAGAAATTTATTTCAGGTAAGGGTAATATTTTAATAGTAGTCAATAATCTAGCTTAAGGCTGTAACT
 481 CTTCTATCGGGGCTAATTGTATGAATAGGTGTCAGTATGTTGAAGATTACTTTCTTTTGTGACTTTCTTCTACCTCATGC
 561 CACTGTTTAAAAGTAAAACGTATTTTAATGATGTTAGAATAAGACTACCATTCTAAATATCACCTACTTATGAATAACAT
 641 GTAATAATTTTTAACATTAATGATTCCATAAATTGTATTATTGGGATTAGAATGTGCTTTATGACAGGTTAGTGTTTCCT
 721 CTGAGGCAGAAAACTCTTTTTTGGAGATATCTTCCATCAAGCAGTACTCGTGCCCATATACAATCTCTTAGTGGCTAGGA
 801 GAAATAAATAAAAGGGCCATAATGGTTTGTTCTCTTTCAGACATAATTTAGTAGGGGACAAGAAGTCTGTTCTTCAGTGA
 881 GTACACTAGAGATTTACTCTGGTGACTGCCTTTTGAGTTATGGGTGAAGTAAGGTATGGCTTTACCATAACCTTGATTCA
 961 TTCACCCTTGATTCATTTCTCGCCCCCGTCACTGATTATTTCCTTGAGCATATATCTCTGCCTAACACTTTAGTAGGTGC
1041 TATAGAGGATACATGAAAAGTATGAGATCTGGTTCCATCCAGTAAGACATTTTAATAGAGAAGATCAAAATGTTACCTGG
1121 CAGTTGGGGAATAATCTGACTTCGTTGGCAGTTGGCCTTAACTTCTTAATCATTGATCCAGGAATATTTCAACCAGAGAC
1201 ACAACTTTCTGGCAGACAGACAAATTGTACAACACCAACAATATCCTGGACCTTGAAATTCTGTTTACTTCAGTCCATTG
1281 TATCCTTTAAGGCACCTGTGCTAGCCTAGATTTTGTAATAACACTGATTTATGAGAATGGACAAAAGTGGTAGGGAAATT
1361 GTTCCCTCTCCACTTCTGAAAGTATGATGATGTATTAAGGATGGAGGAGTTATTAAAAATGTCTCTTCTGATGAGGTAAC
1441 AATTAGATGAAACCATGTTAAAGCTGAGATGAACACTTAGAAATTCAGGGATATTGGGTCTTTAGCCTTATGAATTTGAG
1521 CTGCTTATTTAATTGGTGTAATTTACTACATATTAGTACTATATTCGTAAGGATTTTTTATTAACCATTACAGATTTTAC
1601 AAACAGCTAGTTATATGGTAAACAGATTATTATGCCTTTTTGCAATTCTGAATATGATTCTAGTATTTGTGTAGATGTAT
1681 TTGGTACTTTTTCCCCTAATTCCAACACTAGTTTATATATATAGCGAATAAATCTAGTTGTATAAATTTTTAAATGCCGT
1761 CAGTAGAAAGCACACAAGGTTATGATTTTTTTAATTACTGGCTTCTGATTTCTTTCACTTCTGATCCTTTTCCTTTTTCT
1841 CAGATGTAGCTGAGTCTTGATCATTTTAAGACAACGATGGGTAGAATTTTGAGATTAATGTTAATTTTCCCTTTTTGTTA
1921 ATTTCAGTCCCCTCTCACTATGCTTTTGTCCAGAAGGATCAAGAATTCTACCATCCCTTGGGTCTTTGTGTATAAACAAT
2001 GTTAAATAAAGGTAGACTCAGTCTTTAAGATATTAGACAGTTTTTTTAGTCCATGGGATTGTAAATATAAACATTAACTT
2081 TCCTATAAGAATATTTTGGCTTTGTAATCTATAGCCTCAAATTGGTATTTATTATGGATTCACTAGACAAACAGCTGTTT
2161 CCTTATTGTCTTTTTTCTTTAGTGTTTCTGATTTGCTATCAGTAGCTGTTTTTAAAGCCGTCCAAGGAAAATAATTATTT
2241 ACAGTTTTTGAAGTCACTTTTGAGCCCTCATCAAGCTCTCATTGTGATGGGAGGGATACCTTTTTGTTGTTAAAAGCCTA
2321 TTATTGTTAAAGGCCTTTTATGGAAACCAACTTGGAAAACAACCTTAAATGTGGATGTATCAGATTTGGTTTATCCAGCC
2401 ATGGGAGAGAAAACAAACCTAAGTTTACTTTACTTGTACATATACACTACAATGGATAGTATATTTGCTGTAAACTACAA
2481 TGTAAAACCTCAATAAAAGTGCGCTGTACTTCTTAATGTTTATTAAAAGATGTATTTTTACAAAAAAAAAAAAAAAAAAA
2561 AAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uccgUUUUUGGCGUC-AAUGAAAa 5'
              | |||||  || ||||||| 
Target 5' gaaaACAAACCTAAGTTTACTTTa 3'
 2409 - 2432 163.00 -8.60
2 
miRNA  3' uccGUU-UUUGGCGUC-AAUGAAAa 5'
             ||: | :::| || ||||||| 
Target 5' tgtCAGTATGTTGAAGATTACTTTc 3'
 510 - 534 152.00 -7.40
3 
miRNA  3' uccGUUUUUGGCGUCAAUGAAAa 5'
             ||:   ::| ||| ||||| 
Target 5' ttaCAGTTTTTGAAGTCACTTTt 3'
 2239 - 2261 124.00 -9.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN8892566 3 COSMIC
COSN30658639 6 COSMIC
COSN8046050 50 COSMIC
COSN30511102 53 COSMIC
COSN30451707 89 COSMIC
COSN30158857 102 COSMIC
COSN23817912 107 COSMIC
COSN31527515 112 COSMIC
COSN31543379 120 COSMIC
COSN31496011 142 COSMIC
COSN21591127 162 COSMIC
COSN1355268 167 COSMIC
COSN21590449 183 COSMIC
COSN30123452 191 COSMIC
COSN31550264 203 COSMIC
COSN26649689 216 COSMIC
COSN31575153 246 COSMIC
COSN30534462 361 COSMIC
COSN30140195 402 COSMIC
COSN8517834 453 COSMIC
COSN30134638 489 COSMIC
COSN31607223 581 COSMIC
COSN30115852 582 COSMIC
COSN9773812 583 COSMIC
COSN31547065 606 COSMIC
COSN31583859 654 COSMIC
COSN21590450 704 COSMIC
COSN21588355 724 COSMIC
COSN21591128 730 COSMIC
COSN31556564 748 COSMIC
COSN2243103 750 COSMIC
COSN31526513 774 COSMIC
COSN30121833 786 COSMIC
COSN24204850 800 COSMIC
COSN31521450 825 COSMIC
COSN30533980 833 COSMIC
COSN22618571 841 COSMIC
COSN24302066 882 COSMIC
COSN30111184 982 COSMIC
COSN30512720 996 COSMIC
COSN15623672 1004 COSMIC
COSN31485791 1060 COSMIC
COSN30129685 1118 COSMIC
COSN31540686 1121 COSMIC
COSN30170991 1128 COSMIC
COSN26761351 1150 COSMIC
COSN22490192 1153 COSMIC
COSN31517909 1156 COSMIC
COSN19570401 1227 COSMIC
COSN26565434 1274 COSMIC
COSN9773813 1279 COSMIC
COSN24036883 1371 COSMIC
COSN30532732 1431 COSMIC
COSN24302195 1543 COSMIC
COSN8517835 1549 COSMIC
COSN30513397 1700 COSMIC
COSN24159982 1735 COSMIC
COSN30139787 1739 COSMIC
COSN23758019 1785 COSMIC
COSN30139286 1793 COSMIC
COSN28780214 1828 COSMIC
COSN30130498 1887 COSMIC
COSN31534177 1911 COSMIC
COSN30534631 1912 COSMIC
COSN23945464 1913 COSMIC
COSN8046052 1954 COSMIC
COSN30159400 1964 COSMIC
COSN15623673 1978 COSMIC
COSN31535166 1996 COSMIC
COSN17076217 2018 COSMIC
COSN22797478 2048 COSMIC
COSN28782834 2086 COSMIC
COSN30126308 2116 COSMIC
COSN4935774 2138 COSMIC
COSN20745370 2153 COSMIC
COSN31589547 2156 COSMIC
COSN30510630 2176 COSMIC
COSN8046053 2208 COSMIC
COSN30541624 2317 COSMIC
COSN26958569 2321 COSMIC
COSN30529175 2375 COSMIC
COSN15623674 2455 COSMIC
COSN30141532 2497 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs977418221 2 dbSNP
rs928650226 5 dbSNP
rs374720515 9 dbSNP
rs1206908768 10 dbSNP
rs1267989651 12 dbSNP
rs1465732406 19 dbSNP
rs375989620 24 dbSNP
rs769996911 31 dbSNP
rs182726869 33 dbSNP
rs1187748511 36 dbSNP
rs1226803013 39 dbSNP
rs147269114 41 dbSNP
rs1316158945 42 dbSNP
rs866289679 49 dbSNP
rs1395737979 51 dbSNP
rs1377257671 56 dbSNP
rs900273326 59 dbSNP
rs1179310503 71 dbSNP
rs947945946 73 dbSNP
rs999866390 77 dbSNP
rs898274718 79 dbSNP
rs140861444 83 dbSNP
rs891619549 84 dbSNP
rs1427727674 101 dbSNP
rs1386933821 104 dbSNP
rs1188004664 106 dbSNP
rs532905007 109 dbSNP
rs890800093 110 dbSNP
rs1178538518 111 dbSNP
rs1483121516 125 dbSNP
rs3810874 133 dbSNP
rs1414265200 135 dbSNP
rs187870115 140 dbSNP
rs560572122 149 dbSNP
rs1331745815 150 dbSNP
rs1272440914 153 dbSNP
rs906557611 158 dbSNP
rs1244540414 164 dbSNP
rs1378691088 173 dbSNP
rs1447132010 181 dbSNP
rs774645854 191 dbSNP
rs1033653763 192 dbSNP
rs959452294 195 dbSNP
rs973856566 205 dbSNP
rs900083050 208 dbSNP
rs1306254029 210 dbSNP
rs1236327058 211 dbSNP
rs1011768718 215 dbSNP
rs1163722599 223 dbSNP
rs1256518254 225 dbSNP
rs1027862498 230 dbSNP
rs1473129326 231 dbSNP
rs1251638835 237 dbSNP
rs1180638747 243 dbSNP
rs1490998943 255 dbSNP
rs1267404539 259 dbSNP
rs1343977226 260 dbSNP
rs191882778 266 dbSNP
rs967541357 271 dbSNP
rs547780944 278 dbSNP
rs1198534959 298 dbSNP
rs759662047 299 dbSNP
rs559947062 305 dbSNP
rs983742931 316 dbSNP
rs998912183 327 dbSNP
rs1328221542 329 dbSNP
rs1459234257 334 dbSNP
rs912147725 335 dbSNP
rs533404402 337 dbSNP
rs944930760 359 dbSNP
rs1035697540 361 dbSNP
rs1341622967 361 dbSNP
rs1324237708 367 dbSNP
rs183250663 372 dbSNP
rs1201561756 375 dbSNP
rs921560776 377 dbSNP
rs17865130 378 dbSNP
rs775800641 382 dbSNP
rs1171166572 384 dbSNP
rs916540737 386 dbSNP
rs1411668520 387 dbSNP
rs1402960380 388 dbSNP
rs761220112 394 dbSNP
rs969698079 421 dbSNP
rs1378745647 422 dbSNP
rs1465816431 424 dbSNP
rs1449383814 427 dbSNP
rs1263307715 434 dbSNP
rs1208952414 436 dbSNP
rs973988290 442 dbSNP
rs1017104 458 dbSNP
rs891653604 460 dbSNP
rs1345566892 463 dbSNP
rs1274194047 474 dbSNP
rs1232533722 479 dbSNP
rs1329410221 484 dbSNP
rs945853582 487 dbSNP
rs549473969 489 dbSNP
rs533121034 490 dbSNP
rs760268284 492 dbSNP
rs1330426305 493 dbSNP
rs1471169901 500 dbSNP
rs1231028407 502 dbSNP
rs567681750 510 dbSNP
rs1172501538 520 dbSNP
rs1477360361 525 dbSNP
rs1374271262 532 dbSNP
rs1188685236 535 dbSNP
rs550000862 547 dbSNP
rs1318404977 557 dbSNP
rs1336291604 559 dbSNP
rs1245839054 569 dbSNP
rs1205265446 574 dbSNP
rs1442790804 577 dbSNP
rs1017105 580 dbSNP
rs1012253900 581 dbSNP
rs1017106 590 dbSNP
rs895147073 592 dbSNP
rs552639099 596 dbSNP
rs1295686881 609 dbSNP
rs1268208384 614 dbSNP
rs994966682 631 dbSNP
rs903352549 639 dbSNP
rs1413233891 645 dbSNP
rs1399297577 659 dbSNP
rs374000239 660 dbSNP
rs1428553214 666 dbSNP
rs1451510157 669 dbSNP
rs1028134579 678 dbSNP
rs1387862871 681 dbSNP
rs1185042417 702 dbSNP
rs1472953732 705 dbSNP
rs1236655377 708 dbSNP
rs950806358 719 dbSNP
rs984038424 742 dbSNP
rs1439444036 750 dbSNP
rs1275284469 751 dbSNP
rs998944770 759 dbSNP
rs1019037247 770 dbSNP
rs966267349 771 dbSNP
rs1478353974 778 dbSNP
rs1283932650 792 dbSNP
rs1446308788 793 dbSNP
rs1480633045 799 dbSNP
rs376739855 817 dbSNP
rs567106439 820 dbSNP
rs1409819331 831 dbSNP
rs534834365 835 dbSNP
rs754923918 842 dbSNP
rs1368142857 845 dbSNP
rs963389194 852 dbSNP
rs1421044873 856 dbSNP
rs974400768 857 dbSNP
rs974961464 860 dbSNP
rs921635723 865 dbSNP
rs935650705 876 dbSNP
rs1471043531 878 dbSNP
rs1293571453 884 dbSNP
rs1252356341 886 dbSNP
rs750152497 890 dbSNP
rs1384990512 893 dbSNP
rs1249674258 899 dbSNP
rs912992887 904 dbSNP
rs982612622 911 dbSNP
rs1289445533 922 dbSNP
rs1226894064 924 dbSNP
rs1331653911 927 dbSNP
rs140787647 927 dbSNP
rs1217821009 934 dbSNP
rs1349222438 935 dbSNP
rs945789489 937 dbSNP
rs1436593969 947 dbSNP
rs1348873072 948 dbSNP
rs1321175332 949 dbSNP
rs932326055 951 dbSNP
rs193147106 953 dbSNP
rs1158199722 961 dbSNP
rs1247314127 965 dbSNP
rs1471546613 966 dbSNP
rs906996301 975 dbSNP
rs920946811 982 dbSNP
rs937281533 983 dbSNP
rs947032141 983 dbSNP
rs1466456646 984 dbSNP
rs778741633 985 dbSNP
rs895178364 986 dbSNP
rs995263893 988 dbSNP
rs1049027514 995 dbSNP
rs1266011398 1003 dbSNP
rs903426027 1004 dbSNP
rs1193362122 1006 dbSNP
rs1261530209 1010 dbSNP
rs886530167 1011 dbSNP
rs934869590 1013 dbSNP
rs1057210209 1014 dbSNP
rs1436790996 1017 dbSNP
rs547044063 1025 dbSNP
rs571569072 1032 dbSNP
rs1019108615 1034 dbSNP
rs556714945 1041 dbSNP
rs1455939440 1044 dbSNP
rs996411871 1051 dbSNP
rs575067068 1054 dbSNP
rs1029180653 1055 dbSNP
rs538983399 1059 dbSNP
rs957622732 1061 dbSNP
rs1424520538 1080 dbSNP
rs899170131 1087 dbSNP
rs1451513203 1090 dbSNP
rs754778051 1096 dbSNP
rs1361115269 1099 dbSNP
rs1399382784 1115 dbSNP
rs1188257270 1127 dbSNP
rs1463822025 1128 dbSNP
rs142246998 1141 dbSNP
rs1027358393 1144 dbSNP
rs11563542 1145 dbSNP
rs1230005617 1146 dbSNP
rs748038842 1157 dbSNP
rs1296423810 1166 dbSNP
rs1432532566 1167 dbSNP
rs928487682 1171 dbSNP
rs572751121 1173 dbSNP
rs1465452920 1175 dbSNP
rs975568982 1177 dbSNP
rs576056629 1182 dbSNP
rs1321153174 1189 dbSNP
rs1168187142 1191 dbSNP
rs1427013136 1191 dbSNP
rs1243896507 1194 dbSNP
rs1258669180 1200 dbSNP
rs947073657 1201 dbSNP
rs1483181859 1203 dbSNP
rs1256038868 1217 dbSNP
rs1206594484 1227 dbSNP
rs540218408 1236 dbSNP
rs1273357484 1238 dbSNP
rs1288305075 1239 dbSNP
rs536938497 1243 dbSNP
rs151249770 1247 dbSNP
rs934927186 1248 dbSNP
rs555238649 1253 dbSNP
rs1376806671 1258 dbSNP
rs895991227 1264 dbSNP
rs948855688 1269 dbSNP
rs1044911159 1271 dbSNP
rs1049534377 1273 dbSNP
rs886436147 1274 dbSNP
rs1168084725 1277 dbSNP
rs1182013421 1281 dbSNP
rs1370441770 1283 dbSNP
rs1255085510 1287 dbSNP
rs1005408928 1296 dbSNP
rs1165859003 1299 dbSNP
rs1423601634 1312 dbSNP
rs772162884 1325 dbSNP
rs1040420941 1330 dbSNP
rs1483696092 1334 dbSNP
rs533659745 1339 dbSNP
rs781394155 1343 dbSNP
rs1489227199 1348 dbSNP
rs996320503 1356 dbSNP
rs1421494035 1359 dbSNP
rs775641475 1362 dbSNP
rs899246704 1363 dbSNP
rs995272217 1376 dbSNP
rs1290038988 1390 dbSNP
rs1179948472 1399 dbSNP
rs1380422565 1406 dbSNP
rs1026303981 1408 dbSNP
rs747407397 1410 dbSNP
rs1029090662 1420 dbSNP
rs17861306 1424 dbSNP
rs886408648 1426 dbSNP
rs1004148918 1435 dbSNP
rs34833025 1438 dbSNP
rs1019502395 1448 dbSNP
rs1294333584 1453 dbSNP
rs1457646450 1456 dbSNP
rs957866681 1463 dbSNP
rs1360627967 1467 dbSNP
rs965213810 1468 dbSNP
rs1011794834 1471 dbSNP
rs745904312 1479 dbSNP
rs552033731 1488 dbSNP
rs1020409995 1492 dbSNP
rs758483645 1494 dbSNP
rs1178971100 1495 dbSNP
rs1434396237 1505 dbSNP
rs1267511875 1508 dbSNP
rs967063239 1519 dbSNP
rs1208852565 1528 dbSNP
rs769881194 1539 dbSNP
rs1378687437 1541 dbSNP
rs1269744016 1549 dbSNP
rs1209145387 1557 dbSNP
rs1328320779 1560 dbSNP
rs1450772647 1561 dbSNP
rs563896573 1567 dbSNP
rs531095413 1568 dbSNP
rs1386395021 1579 dbSNP
rs17867644 1599 dbSNP
rs928352216 1610 dbSNP
rs1458105363 1615 dbSNP
rs978863706 1617 dbSNP
rs762216364 1625 dbSNP
rs1468077747 1631 dbSNP
rs924298842 1633 dbSNP
rs934288696 1645 dbSNP
rs991328066 1655 dbSNP
rs1452131616 1662 dbSNP
rs1249523650 1666 dbSNP
rs1188892883 1675 dbSNP
rs1464268800 1676 dbSNP
rs919730924 1678 dbSNP
rs931262369 1679 dbSNP
rs1211293525 1685 dbSNP
rs764872441 1694 dbSNP
rs1202086053 1695 dbSNP
rs540782667 1704 dbSNP
rs907894060 1705 dbSNP
rs940676159 1709 dbSNP
rs1256619712 1712 dbSNP
rs1233683720 1714 dbSNP
rs1368975464 1714 dbSNP
rs1300096104 1716 dbSNP
rs1040328332 1718 dbSNP
rs901949934 1720 dbSNP
rs917492584 1721 dbSNP
rs932036114 1726 dbSNP
rs559357320 1727 dbSNP
rs1403567804 1737 dbSNP
rs893301629 1738 dbSNP
rs766157192 1745 dbSNP
rs1171425269 1749 dbSNP
rs534758357 1758 dbSNP
rs777199816 1759 dbSNP
rs930760045 1760 dbSNP
rs1047817247 1762 dbSNP
rs886441156 1768 dbSNP
rs1448550405 1771 dbSNP
rs1240112127 1773 dbSNP
rs1189399121 1776 dbSNP
rs902873098 1778 dbSNP
rs1002551520 1780 dbSNP
rs1442880662 1784 dbSNP
rs1255396559 1786 dbSNP
rs1176630485 1788 dbSNP
rs1035319829 1792 dbSNP
rs1008866447 1793 dbSNP
rs958446477 1794 dbSNP
rs546965228 1797 dbSNP
rs1027265526 1802 dbSNP
rs1175047169 1811 dbSNP
rs952560771 1820 dbSNP
rs571487034 1827 dbSNP
rs1468418122 1830 dbSNP
rs397759219 1833 dbSNP
rs397829267 1834 dbSNP
rs1333632831 1835 dbSNP
rs1401034875 1847 dbSNP
rs1268738832 1854 dbSNP
rs901086369 1857 dbSNP
rs1341525427 1860 dbSNP
rs577566452 1863 dbSNP
rs1312801622 1865 dbSNP
rs1446170006 1869 dbSNP
rs184613376 1875 dbSNP
rs943930679 1876 dbSNP
rs769109092 1877 dbSNP
rs751187006 1880 dbSNP
rs1164716133 1883 dbSNP
rs932109832 1894 dbSNP
rs1370335953 1905 dbSNP
rs999951759 1905 dbSNP
rs1050526265 1911 dbSNP
rs1048883 1918 dbSNP
rs893323586 1928 dbSNP
rs1301013251 1932 dbSNP
rs1031349699 1933 dbSNP
rs770889312 1941 dbSNP
rs1042255724 1944 dbSNP
rs556800887 1964 dbSNP
rs1205988867 1967 dbSNP
rs1437404656 1978 dbSNP
rs1220031653 1981 dbSNP
rs754831345 1985 dbSNP
rs992452555 1992 dbSNP
rs1258313188 1994 dbSNP
rs767405026 2006 dbSNP
rs774762433 2007 dbSNP
rs970325178 2020 dbSNP
rs1035394292 2022 dbSNP
rs1352898945 2029 dbSNP
rs1288375953 2035 dbSNP
rs894138443 2039 dbSNP
rs781641197 2048 dbSNP
rs1247987207 2057 dbSNP
rs1012698606 2063 dbSNP
rs568718729 2067 dbSNP
rs1026715065 2072 dbSNP
rs1352335014 2079 dbSNP
rs186714887 2086 dbSNP
rs1405647009 2087 dbSNP
rs982647638 2088 dbSNP
rs1478681950 2092 dbSNP
rs1162570148 2094 dbSNP
rs558116406 2098 dbSNP
rs572884216 2101 dbSNP
rs930764716 2111 dbSNP
rs191175070 2114 dbSNP
rs1182906250 2132 dbSNP
rs1469690049 2135 dbSNP
rs370567033 2139 dbSNP
rs1465346932 2142 dbSNP
rs1224019264 2146 dbSNP
rs976635967 2157 dbSNP
rs923308201 2165 dbSNP
rs755973015 2166 dbSNP
rs1047849387 2167 dbSNP
rs745517196 2170 dbSNP
rs1272900117 2173 dbSNP
rs931973835 2181 dbSNP
rs1331761043 2183 dbSNP
rs1293475661 2185 dbSNP
rs986645515 2195 dbSNP
rs544649141 2199 dbSNP
rs947424244 2217 dbSNP
rs1289526240 2218 dbSNP
rs1041890726 2220 dbSNP
rs9731 2221 dbSNP
rs938947137 2223 dbSNP
rs1446345598 2228 dbSNP
rs901114812 2230 dbSNP
rs576737071 2242 dbSNP
rs1369822644 2253 dbSNP
rs1323584028 2257 dbSNP
rs745956902 2265 dbSNP
rs1389192782 2293 dbSNP
rs1158273121 2300 dbSNP
rs1316883037 2318 dbSNP
rs1405844726 2319 dbSNP
rs894169464 2321 dbSNP
rs1192064772 2327 dbSNP
rs1466524143 2330 dbSNP
rs1012602241 2336 dbSNP
rs1215674137 2337 dbSNP
rs1315698081 2343 dbSNP
rs1280072272 2344 dbSNP
rs545732176 2355 dbSNP
rs1346619779 2358 dbSNP
rs1300801034 2363 dbSNP
rs1436906132 2373 dbSNP
rs17863096 2376 dbSNP
rs888211500 2378 dbSNP
rs1004331449 2380 dbSNP
rs1178254743 2394 dbSNP
rs1266722145 2394 dbSNP
rs1435418017 2395 dbSNP
rs1023940250 2402 dbSNP
rs1451611393 2415 dbSNP
rs531134386 2433 dbSNP
rs780262130 2437 dbSNP
rs980379733 2442 dbSNP
rs747178785 2445 dbSNP
rs920807704 2446 dbSNP
rs1485051455 2447 dbSNP
rs1277638017 2456 dbSNP
rs1230123160 2459 dbSNP
rs1489120300 2462 dbSNP
rs965175977 2470 dbSNP
rs1294523360 2480 dbSNP
rs530747526 2483 dbSNP
rs998090009 2490 dbSNP
rs543242983 2491 dbSNP
rs561267693 2493 dbSNP
rs1028179618 2494 dbSNP
rs953942632 2496 dbSNP
rs184005906 2503 dbSNP
rs914516784 2504 dbSNP
rs1414150112 2512 dbSNP
rs1475207043 2516 dbSNP
rs1311180978 2529 dbSNP
rs17866176 2529 dbSNP
rs776979988 2531 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760583. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_A ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000287916.4 | 3UTR | AUUACUUUCUUUUGUGACUUUCUUCUACCUCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
184 hsa-miR-548w Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057125 DDIT4 DNA damage inducible transcript 4 2 4
MIRT063369 ETNK1 ethanolamine kinase 1 2 2
MIRT072492 RAB8B RAB8B, member RAS oncogene family 2 2
MIRT082186 ACTN4 actinin alpha 4 2 6
MIRT083033 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT085188 SLC5A3 solute carrier family 5 member 3 2 4
MIRT088905 FOXN2 forkhead box N2 2 4
MIRT089494 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 6
MIRT092039 ABHD5 abhydrolase domain containing 5 2 2
MIRT094685 FEM1C fem-1 homolog C 2 2
MIRT095393 UBE2D2 ubiquitin conjugating enzyme E2 D2 2 2
MIRT096501 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT101296 FAM135A family with sequence similarity 135 member A 2 2
MIRT103356 CBX3 chromobox 3 2 2
MIRT103872 FOXK1 forkhead box K1 2 2
MIRT104334 CLDN12 claudin 12 2 2
MIRT104501 PEG10 paternally expressed 10 2 6
MIRT111795 MPZL1 myelin protein zero like 1 2 2
MIRT177238 BMI1 BMI1 proto-oncogene, polycomb ring finger 2 2
MIRT177273 COMMD3-BMI1 COMMD3-BMI1 readthrough 2 2
MIRT177626 UBE2D1 ubiquitin conjugating enzyme E2 D1 2 6
MIRT178042 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT179102 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 6
MIRT179587 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 6
MIRT195299 LEPROT leptin receptor overlapping transcript 2 2
MIRT203143 BACH1 BTB domain and CNC homolog 1 2 2
MIRT208430 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT214578 SMAD5 SMAD family member 5 2 4
MIRT216103 IL6ST interleukin 6 signal transducer 2 2
MIRT216355 CCNB1 cyclin B1 2 4
MIRT220050 MDFIC MyoD family inhibitor domain containing 2 2
MIRT226729 ANP32B acidic nuclear phosphoprotein 32 family member B 2 4
MIRT227698 TBC1D13 TBC1 domain family member 13 2 2
MIRT230071 SH3BGRL SH3 domain binding glutamate rich protein like 2 2
MIRT248637 HMGN2 high mobility group nucleosomal binding domain 2 2 4
MIRT254790 XRCC6 X-ray repair cross complementing 6 2 6
MIRT264376 YAP1 Yes associated protein 1 2 2
MIRT266972 LRRC55 leucine rich repeat containing 55 2 4
MIRT273949 SPRYD4 SPRY domain containing 4 2 2
MIRT281802 MAP2K1 mitogen-activated protein kinase kinase 1 2 2
MIRT293252 DR1 down-regulator of transcription 1 2 2
MIRT297097 RGPD4 RANBP2-like and GRIP domain containing 4 2 2
MIRT308170 PDE12 phosphodiesterase 12 2 2
MIRT309013 USP53 ubiquitin specific peptidase 53 2 2
MIRT311470 PRRC1 proline rich coiled-coil 1 2 2
MIRT312586 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT328130 ZNF711 zinc finger protein 711 2 2
MIRT329313 FAM53C family with sequence similarity 53 member C 2 2
MIRT334642 NEK7 NIMA related kinase 7 2 2
MIRT340673 THRAP3 thyroid hormone receptor associated protein 3 2 2
MIRT378858 ITGB8 integrin subunit beta 8 2 2
MIRT395789 SPCS3 signal peptidase complex subunit 3 2 2
MIRT405639 WBP4 WW domain binding protein 4 2 4
MIRT408287 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT442097 ZNRF2 zinc and ring finger 2 2 8
MIRT442840 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT443116 VLDLR very low density lipoprotein receptor 2 2
MIRT443147 ZDHHC21 zinc finger DHHC-type containing 21 2 2
MIRT443298 PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 2 2
MIRT445080 ZNF207 zinc finger protein 207 2 2
MIRT445384 PTCHD1 patched domain containing 1 2 4
MIRT447070 MCC mutated in colorectal cancers 2 2
MIRT447300 ZNF562 zinc finger protein 562 2 2
MIRT447512 MRPS5 mitochondrial ribosomal protein S5 2 2
MIRT449511 TM6SF1 transmembrane 6 superfamily member 1 2 2
MIRT449902 C11orf34 placenta expressed transcript 1 1 2
MIRT450551 SHFM1 SEM1, 26S proteasome complex subunit 2 2
MIRT450719 PVRL3 nectin cell adhesion molecule 3 2 2
MIRT454923 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 12
MIRT455892 KIF2C kinesin family member 2C 2 2
MIRT463732 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 8
MIRT471182 PHB2 prohibitin 2 2 2
MIRT472764 MTMR6 myotubularin related protein 6 2 8
MIRT474457 KLHL11 kelch like family member 11 2 8
MIRT475985 GTPBP2 GTP binding protein 2 2 2
MIRT482277 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT485858 ALG9 ALG9, alpha-1,2-mannosyltransferase 2 2
MIRT486192 ERH ERH, mRNA splicing and mitosis factor 2 4
MIRT488609 FAM3C family with sequence similarity 3 member C 2 6
MIRT489984 DDB1 damage specific DNA binding protein 1 2 2
MIRT493476 IPMK inositol polyphosphate multikinase 2 2
MIRT494280 CEP120 centrosomal protein 120 2 2
MIRT497992 ZBTB20 zinc finger and BTB domain containing 20 2 2
MIRT498473 PTBP2 polypyrimidine tract binding protein 2 2 10
MIRT498559 TMEM30B transmembrane protein 30B 2 2
MIRT499867 SVOP SV2 related protein 2 10
MIRT500220 INHBA inhibin beta A subunit 2 10
MIRT500694 TRIM37 tripartite motif containing 37 2 2
MIRT500988 SPPL2A signal peptide peptidase like 2A 2 4
MIRT501023 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 6
MIRT502736 CLIP1 CAP-Gly domain containing linker protein 1 2 8
MIRT502798 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 6
MIRT502887 CDK4 cyclin dependent kinase 4 2 8
MIRT503483 ZNF154 zinc finger protein 154 2 6
MIRT503717 GRM5 glutamate metabotropic receptor 5 2 2
MIRT505137 YOD1 YOD1 deubiquitinase 2 2
MIRT505802 RSBN1 round spermatid basic protein 1 2 8
MIRT505841 POLR1B RNA polymerase I subunit B 2 4
MIRT509284 NPM3 nucleophosmin/nucleoplasmin 3 2 6
MIRT516829 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT520519 TRA2B transformer 2 beta homolog 2 2
MIRT520723 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT525403 SHISA9 shisa family member 9 2 4
MIRT525867 ARL13B ADP ribosylation factor like GTPase 13B 2 2
MIRT526013 RBM4B RNA binding motif protein 4B 2 2
MIRT526084 TMEM41B transmembrane protein 41B 2 2
MIRT527931 FRY FRY microtubule binding protein 2 2
MIRT528818 RAB32 RAB32, member RAS oncogene family 2 2
MIRT531062 SLC9A4 solute carrier family 9 member A4 2 4
MIRT535495 PANX1 pannexin 1 2 2
MIRT536682 IKZF5 IKAROS family zinc finger 5 2 2
MIRT536835 HMBOX1 homeobox containing 1 2 2
MIRT537202 GDE1 glycerophosphodiester phosphodiesterase 1 2 4
MIRT537834 EFNA5 ephrin A5 2 2
MIRT538345 CSE1L chromosome segregation 1 like 2 4
MIRT541242 GPC4 glypican 4 2 2
MIRT543235 PEX7 peroxisomal biogenesis factor 7 2 2
MIRT543450 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT543711 XKR9 XK related 9 2 2
MIRT543907 ESYT1 extended synaptotagmin 1 2 2
MIRT543999 KLRC3 killer cell lectin like receptor C3 2 2
MIRT544070 METTL8 methyltransferase like 8 2 2
MIRT544187 ANGPTL3 angiopoietin like 3 2 2
MIRT544808 ACSM2B acyl-CoA synthetase medium chain family member 2B 2 2
MIRT545046 PRELID1 PRELI domain containing 1 2 2
MIRT545214 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT545289 SPC25 SPC25, NDC80 kinetochore complex component 2 2
MIRT545550 GIMAP4 GTPase, IMAP family member 4 2 2
MIRT546497 SIK1 salt inducible kinase 1 2 2
MIRT546914 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT547675 KPNA1 karyopherin subunit alpha 1 2 4
MIRT547770 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT548687 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 2
MIRT548901 CHEK2 checkpoint kinase 2 2 4
MIRT549957 RPL7L1 ribosomal protein L7 like 1 2 4
MIRT550489 TMEM241 transmembrane protein 241 2 2
MIRT551049 MKLN1 muskelin 1 2 2
MIRT552811 XIAP X-linked inhibitor of apoptosis 2 4
MIRT553145 UBE2H ubiquitin conjugating enzyme E2 H 2 2
MIRT553830 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT554258 SIX4 SIX homeobox 4 2 2
MIRT555781 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 2
MIRT556318 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT556499 LIPA lipase A, lysosomal acid type 2 2
MIRT556693 KLHL28 kelch like family member 28 2 2
MIRT556752 KLF7 Kruppel like factor 7 2 2
MIRT556990 HPRT1 hypoxanthine phosphoribosyltransferase 1 2 2
MIRT557146 HOXA13 homeobox A13 2 2
MIRT557487 GPR27 G protein-coupled receptor 27 2 4
MIRT558102 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT559344 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT560335 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT561299 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT561883 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT561927 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT562935 TNIP2 TNFAIP3 interacting protein 2 2 2
MIRT563291 BBS10 Bardet-Biedl syndrome 10 2 2
MIRT563405 KIF3A kinesin family member 3A 2 2
MIRT563562 KIAA1586 KIAA1586 2 2
MIRT565876 NHS NHS actin remodeling regulator 2 2
MIRT566081 RCC2 regulator of chromosome condensation 2 2 2
MIRT566396 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT567259 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT571468 CCDC80 coiled-coil domain containing 80 2 2
MIRT572939 VDAC2 voltage dependent anion channel 2 2 2
MIRT573628 ZNF724P zinc finger protein 724 2 2
MIRT573717 KHSRP KH-type splicing regulatory protein 2 2
MIRT609088 SMIM15 small integral membrane protein 15 2 6
MIRT617936 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT618379 PRKG2 protein kinase, cGMP-dependent, type II 2 2
MIRT619627 PLEKHG7 pleckstrin homology and RhoGEF domain containing G7 2 2
MIRT623455 KDM5A lysine demethylase 5A 2 2
MIRT629145 CTCFL CCCTC-binding factor like 2 2
MIRT638521 LYRM2 LYR motif containing 2 2 2
MIRT649483 CLDN16 claudin 16 2 2
MIRT683148 MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 2 2
MIRT691660 SLC43A3 solute carrier family 43 member 3 2 2
MIRT693201 MKI67 marker of proliferation Ki-67 2 2
MIRT695334 AQP3 aquaporin 3 (Gill blood group) 2 2
MIRT701023 PCGF5 polycomb group ring finger 5 2 2
MIRT708753 RYBP RING1 and YY1 binding protein 2 2
MIRT717558 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT719286 SETD7 SET domain containing lysine methyltransferase 7 2 2
MIRT725172 SDAD1 SDA1 domain containing 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-548w Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-548w Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-miR-548w Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-548w Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-548w Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-548w Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-548w Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-548w Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-548w Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-548w Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-548w Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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