miRTarBase - #MIRT108294


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pre-miRNA Information
pre-miRNA hsa-mir-642b   
Genomic Coordinates chr19: 45674932 - 45675008
Description Homo sapiens miR-642b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-642b-3p
Sequence 47| AGACACAUUUGGAGAGGGACCC |68
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN24410683 6 COSMIC
COSN8407659 14 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778534861 2 dbSNP
rs111664333 4 dbSNP
rs998995912 5 dbSNP
rs1206620651 6 dbSNP
rs1317907103 7 dbSNP
rs374751972 13 dbSNP
rs78902025 15 dbSNP
rs775648115 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol BHLHB9   
Synonyms GASP3, p60TRP
Description basic helix-loop-helix family member b9
Transcript NM_001142524   
Other Transcripts NM_001142525 , NM_001142526 , NM_001142527 , NM_001142528 , NM_001142529 , NM_001142530 , NM_030639   
Expression
Putative miRNA Targets on BHLHB9
3'UTR of BHLHB9
(miRNA target sites are highlighted)		 
>BHLHB9|NM_001142524|3'UTR
   1 AATGAGCCAGAGATAGAACATTTTAAGCCATCTTCAAACTCTAGCAGGCTGTACATTACAGTGTACACATTATACACTGC
  81 ATCTTTAACACAGAGTCACCTGTGACAGGCTCTAGGTTTGAGCTAGACTATTTTGGGGGTATCAAATGAATATTATACCT
 161 TGGGCTGAAAATGTTTGATTTTTATCTTGTCTAGATTGGCATATTTTTAACATTTTACTTAAGATAGCAAACCAGTTCGT
 241 TTTAAGTAAGCTAACTTGTTCATTAGTATCTGTGGCTTAAAATGGCAAAAAAGAAAATATCCTTGAGTTTGTAATCTAGT
 321 TACAGAAGTAAGGCATACACACACACAAAGATAACAGTACCTAGAGAGAGAGTGTGTGTGAGTGTGCGTGTCTCTGTGTG
 401 TGCACGTGCACGCTCATGGCCAAATGTGCGCACTCTACATAAAGGAGGCAGGAGTTCCTATAGGCTATTTAATGTAAGAG
 481 AAACTATTTTTCTCCTGTTCCAGCTGTATCAGATACTCGTTCCGCAACACAGAAATGACTCAGAATCTCAGACAAAATGT
 561 ATTATTTGTTCAATTTTAATTTTGCTACTACATTCATAACTCTTAAATTGTTAGGCTGTTTCATTTACATCAAAGTTATC
 641 TCACAAAAGAGAAGGCAGGAAACGTTTTGTGAGTGCCTATTCTATGTCAAACACTGTGTTGGCACCATATTTTACAAGTT
 721 TTTTTCCTCTTCTCACAGTGATCTTGTGAGTTAGTTACTTATATTTTTATTAGAACTCATTATTCTGGGTACCCTCCAAT
 801 GAGAATTAGAGAGGTTAAATACCTTTTCCTAGATTCCCACAGCAGGAAGGTGGCATAGCTGTTTTGTCTGACACCAGAAC
 881 CCATCTCACCACACTGCTTTACAGTCTTCCTGAAGGACATTTTGAGGTGGGGGGGCCTTCAAAGCTCAGAGACTGGTTTG
 961 AATGGTTTAATTTTGCAATGGATCATGTCCATGCCAGGTGTTACAATTCTTAACTTCCTCCAAATTCGTGTGTCCATTAG
1041 ACATTTGGCTACATCTGGCTGGAGGTCAGGAGAAAATTCTGAGGTAAATAGATGGATTTTATCTGGCAGTGTCGAAAATA
1121 GTAGGAGCCTAAAACTTTGTTCAATGAGTAAGATGTAGATTTGGAGTCATCAGCAGGGGAAACTTGTTAGATGTCCTTTG
1201 TATCTTTTTCTATCCATTTGTATTTTTTCTTTCCCAAAGAGCTGAAATCATTTTATACCCTGAATTTAAAAGGTAATTGC
1281 TTTTTTCCTCCTTGCGAAATCATACCTTAATTTTTTTTTTTTTTTTTTTTACCATTTATGATTTATTCTCCTATGTGTCA
1361 TATGAAAGGCCAAGGGGCTTTATCTTTTACTAGTAGGCAAGCCTGGGCATTTCTGCATTTGTGCCAGCTAACACTACAAA
1441 ATAGACTTAATTAGAGAAATTTAGACCCAGAATTGCAGCTTCAACAACACAAAACAGGAAAGCTAGAAGAGGTTGCTGTG
1521 TCAACCTACAAGATAGTGATTCTTGGAAGTTGGTATGGACCAGAAAGCATTCCCAGGACATTTAGGCTATGGCTGAGTTC
1601 TCTAAGACTCAGGGTGGGAATTATAATCCCTGGTCTAAGCTGATATGAAAGTTTCTATGTGTGAAAATATGGAGTTATAT
1681 GCTTTGAGATTTTCTGCCAGTTAAACTAAAACAAGATCATACTGTAAATGTTTGTAACTTGCTTCCCCCCACTGTATACT
1761 GTAAACATCTTTGCATGTCAATAAATATGCCTCTACAACATAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cccAGGGAGAGGUUUACACAGa 5'
             |: :|||||  ||||||| 
Target 5' gatTTATTCTCC-TATGTGTCa 3'
 1340 - 1360 158.00 -16.50
2 
miRNA  3' cccaGGGAGAGGUU----UACACAGa 5'
              |:: ||||||    :|||||| 
Target 5' ttaaCTTCCTCCAAATTCGTGTGTCc 3'
 1010 - 1035 144.00 -16.00
3 
miRNA  3' cccagggAGAGGUUUACACAga 5'
                 |:||:  ||||||  
Target 5' atgaaagTTTCT--ATGTGTga 3'
 1645 - 1664 127.00 -8.20
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1203930338 2 dbSNP
rs1340893100 11 dbSNP
rs1264671702 14 dbSNP
rs1456150822 15 dbSNP
rs757072249 19 dbSNP
rs1326265112 30 dbSNP
rs1251616881 39 dbSNP
rs1421401640 42 dbSNP
rs370688868 43 dbSNP
rs746115931 47 dbSNP
rs755975511 56 dbSNP
rs1486822278 75 dbSNP
rs943062425 80 dbSNP
rs1375482843 85 dbSNP
rs1053443198 95 dbSNP
rs1477964347 100 dbSNP
rs111321025 112 dbSNP
rs180743593 113 dbSNP
rs1191985228 121 dbSNP
rs1486919226 124 dbSNP
rs1480469151 125 dbSNP
rs1201215907 126 dbSNP
rs915502665 129 dbSNP
rs1418907511 131 dbSNP
rs945649512 146 dbSNP
rs1277288693 154 dbSNP
rs1397917936 156 dbSNP
rs1334724627 172 dbSNP
rs769319639 191 dbSNP
rs114554907 196 dbSNP
rs1172249360 198 dbSNP
rs1465778869 200 dbSNP
rs749163604 212 dbSNP
rs1003626202 219 dbSNP
rs1168900637 221 dbSNP
rs1347278505 228 dbSNP
rs1476400475 235 dbSNP
rs1055658824 239 dbSNP
rs762418386 240 dbSNP
rs1441233701 254 dbSNP
rs1252730356 266 dbSNP
rs1199384955 271 dbSNP
rs895225759 271 dbSNP
rs1256413883 277 dbSNP
rs759392397 279 dbSNP
rs1366337809 290 dbSNP
rs1406843703 303 dbSNP
rs1284605471 305 dbSNP
rs765839353 313 dbSNP
rs774298335 321 dbSNP
rs1243944849 329 dbSNP
rs759336904 349 dbSNP
rs778824972 353 dbSNP
rs752235859 363 dbSNP
rs1332748603 364 dbSNP
rs1446893490 367 dbSNP
rs1328857177 372 dbSNP
rs1399026052 372 dbSNP
rs1406804131 389 dbSNP
rs1016920056 406 dbSNP
rs961344444 426 dbSNP
rs1472072781 430 dbSNP
rs993427582 431 dbSNP
rs1026203404 443 dbSNP
rs767352254 451 dbSNP
rs1439148214 461 dbSNP
rs954530554 477 dbSNP
rs752428029 489 dbSNP
rs1290935712 509 dbSNP
rs1490381378 511 dbSNP
rs756414215 514 dbSNP
rs1224038138 515 dbSNP
rs1354092775 519 dbSNP
rs772236107 520 dbSNP
rs186358056 524 dbSNP
rs1230626746 525 dbSNP
rs1306507853 534 dbSNP
rs1480124392 552 dbSNP
rs1177355848 553 dbSNP
rs1410636729 554 dbSNP
rs754007467 569 dbSNP
rs563121227 579 dbSNP
rs1350133379 582 dbSNP
rs1323228650 597 dbSNP
rs1403967115 611 dbSNP
rs1443151276 625 dbSNP
rs779085614 626 dbSNP
rs773438527 637 dbSNP
rs1419662691 639 dbSNP
rs1378525390 650 dbSNP
rs17342421 660 dbSNP
rs914919529 664 dbSNP
rs945007630 665 dbSNP
rs758762585 672 dbSNP
rs1426680392 679 dbSNP
rs1326961268 686 dbSNP
rs138296423 694 dbSNP
rs1287981579 695 dbSNP
rs928215419 703 dbSNP
rs1352959666 708 dbSNP
rs939557964 709 dbSNP
rs1220457391 715 dbSNP
rs1367799257 720 dbSNP
rs1273865900 728 dbSNP
rs1433935682 738 dbSNP
rs1459610529 740 dbSNP
rs1299242333 741 dbSNP
rs1055288312 749 dbSNP
rs1359215760 750 dbSNP
rs1178248023 755 dbSNP
rs1415125328 770 dbSNP
rs771283747 788 dbSNP
rs1171035199 795 dbSNP
rs895247675 815 dbSNP
rs1265035236 817 dbSNP
rs551595463 854 dbSNP
rs1300059028 858 dbSNP
rs530664709 862 dbSNP
rs1450144102 865 dbSNP
rs1240296256 880 dbSNP
rs769476307 882 dbSNP
rs1312258427 914 dbSNP
rs772887043 929 dbSNP
rs548794192 936 dbSNP
rs1217090798 949 dbSNP
rs1314350720 958 dbSNP
rs1319580170 961 dbSNP
rs60286630 976 dbSNP
rs1360095594 979 dbSNP
rs1248029269 986 dbSNP
rs1270278152 1005 dbSNP
rs189437364 1012 dbSNP
rs1449493946 1019 dbSNP
rs1332332360 1028 dbSNP
rs1358619136 1028 dbSNP
rs1306353133 1029 dbSNP
rs1424646597 1037 dbSNP
rs1171051253 1059 dbSNP
rs1477365050 1063 dbSNP
rs1417207742 1085 dbSNP
rs1183492693 1087 dbSNP
rs897167091 1088 dbSNP
rs770445238 1096 dbSNP
rs1204849516 1104 dbSNP
rs1236330162 1113 dbSNP
rs1234254176 1115 dbSNP
rs367916377 1120 dbSNP
rs1026276559 1125 dbSNP
rs181846203 1126 dbSNP
rs16984147 1131 dbSNP
rs1315326613 1139 dbSNP
rs767340688 1140 dbSNP
rs1183345357 1142 dbSNP
rs1244077781 1144 dbSNP
rs571510576 1145 dbSNP
rs1449097086 1146 dbSNP
rs777112521 1151 dbSNP
rs1009170220 1153 dbSNP
rs1166600410 1154 dbSNP
rs567311633 1171 dbSNP
rs1352522187 1176 dbSNP
rs1166677265 1193 dbSNP
rs1424281590 1198 dbSNP
rs1412978090 1221 dbSNP
rs919528936 1239 dbSNP
rs989250116 1246 dbSNP
rs1238333509 1257 dbSNP
rs1418915672 1263 dbSNP
rs1479483415 1264 dbSNP
rs914950747 1272 dbSNP
rs1410596558 1274 dbSNP
rs1321574455 1281 dbSNP
rs1313538609 1291 dbSNP
rs1243036342 1296 dbSNP
rs6652880 1297 dbSNP
rs1444770212 1303 dbSNP
rs1177492332 1311 dbSNP
rs1370035156 1311 dbSNP
rs1416898167 1311 dbSNP
rs201112932 1311 dbSNP
rs57962077 1311 dbSNP
rs796837048 1311 dbSNP
rs879026240 1311 dbSNP
rs1269029414 1313 dbSNP
rs1192081631 1325 dbSNP
rs1404151969 1330 dbSNP
rs1290089806 1331 dbSNP
rs1488356233 1331 dbSNP
rs1452124323 1332 dbSNP
rs1335874906 1334 dbSNP
rs1383167285 1337 dbSNP
rs931871409 1339 dbSNP
rs1268330894 1340 dbSNP
rs1360747139 1341 dbSNP
rs966386239 1342 dbSNP
rs113117345 1343 dbSNP
rs1259645288 1346 dbSNP
rs1320999351 1349 dbSNP
rs1202599467 1351 dbSNP
rs1264152705 1352 dbSNP
rs780278724 1354 dbSNP
rs866635853 1355 dbSNP
rs1043080 1360 dbSNP
rs1462890911 1363 dbSNP
rs1191744354 1371 dbSNP
rs1242010311 1390 dbSNP
rs1475809596 1394 dbSNP
rs1386492390 1398 dbSNP
rs1344604615 1407 dbSNP
rs1188378545 1419 dbSNP
rs1050535865 1422 dbSNP
rs1427238055 1434 dbSNP
rs1301120863 1448 dbSNP
rs754134405 1467 dbSNP
rs762067806 1479 dbSNP
rs1469486472 1495 dbSNP
rs1177344910 1502 dbSNP
rs977720867 1510 dbSNP
rs1406618925 1519 dbSNP
rs1157462824 1546 dbSNP
rs1451014012 1553 dbSNP
rs1176293343 1573 dbSNP
rs372347126 1598 dbSNP
rs1267151256 1599 dbSNP
rs939601150 1601 dbSNP
rs991456175 1611 dbSNP
rs916769960 1614 dbSNP
rs1203950985 1615 dbSNP
rs941493566 1616 dbSNP
rs1038459079 1619 dbSNP
rs897243013 1625 dbSNP
rs1321705717 1629 dbSNP
rs1281098474 1639 dbSNP
rs1220241678 1641 dbSNP
rs929988335 1647 dbSNP
rs750457961 1652 dbSNP
rs1380497233 1656 dbSNP
rs891105988 1658 dbSNP
rs1302943120 1660 dbSNP
rs1465197082 1671 dbSNP
rs1431328439 1678 dbSNP
rs1279578903 1697 dbSNP
rs1478344103 1700 dbSNP
rs1008825983 1703 dbSNP
rs1017904614 1708 dbSNP
rs900336193 1721 dbSNP
rs759937999 1722 dbSNP
rs1283514351 1723 dbSNP
rs1260253505 1750 dbSNP
rs1347667431 1751 dbSNP
rs1199571939 1752 dbSNP
rs1318296498 1754 dbSNP
rs1022033128 1755 dbSNP
rs12388886 1767 dbSNP
rs966420605 1770 dbSNP
rs1312722123 1801 dbSNP
rs1283936502 1809 dbSNP
rs191389379 1819 dbSNP
rs891346831 1820 dbSNP
rs1403335089 1822 dbSNP
rs1004404416 1824 dbSNP
rs1465856366 1826 dbSNP
rs1396199972 1828 dbSNP
rs181400264 1830 dbSNP
rs1474038915 1833 dbSNP
rs898652303 1843 dbSNP
rs55962884 1854 dbSNP
rs149350761 1866 dbSNP
rs1186859722 1868 dbSNP
rs1027405036 1884 dbSNP
rs144138382 1888 dbSNP
rs991081775 1890 dbSNP
rs1181950959 1899 dbSNP
rs991097110 1914 dbSNP
rs1024177938 1915 dbSNP
rs1193861111 1940 dbSNP
rs1431678294 1942 dbSNP
rs1265941376 1948 dbSNP
rs1245236076 1954 dbSNP
rs1379897372 1955 dbSNP
rs1310881664 1956 dbSNP
rs1447003590 1958 dbSNP
rs1334840133 1959 dbSNP
rs1327196657 1960 dbSNP
rs1478915294 1965 dbSNP
rs1407451194 1967 dbSNP
rs767210687 1975 dbSNP
rs1156619280 1977 dbSNP
rs1423348129 1991 dbSNP
rs1383921063 2021 dbSNP
rs1179371617 2026 dbSNP
rs1469758990 2047 dbSNP
rs977293058 2051 dbSNP
rs186206586 2056 dbSNP
rs1401225361 2063 dbSNP
rs1453107740 2072 dbSNP
rs1267840210 2079 dbSNP
rs924467646 2092 dbSNP
rs1299900194 2101 dbSNP
rs916780619 2110 dbSNP
rs1240253065 2118 dbSNP
rs1349435125 2119 dbSNP
rs941579632 2123 dbSNP
rs1363239198 2127 dbSNP
rs903534900 2131 dbSNP
rs781481977 2134 dbSNP
rs1303429075 2140 dbSNP
rs918696796 2140 dbSNP
rs1332480915 2144 dbSNP
rs1403593340 2144 dbSNP
rs1159268105 2148 dbSNP
rs2485253 2150 dbSNP
rs112555071 2154 dbSNP
rs1405963566 2154 dbSNP
rs750095082 2157 dbSNP
rs755887652 2159 dbSNP
rs1290211526 2168 dbSNP
rs1051150462 2182 dbSNP
rs1217324937 2192 dbSNP
rs778541206 2193 dbSNP
rs942656934 2196 dbSNP
rs921339299 2200 dbSNP
rs191109427 2201 dbSNP
rs779688711 2204 dbSNP
rs1181277636 2205 dbSNP
rs1342835476 2222 dbSNP
rs753702294 2232 dbSNP
rs1363027439 2241 dbSNP
rs1022067282 2242 dbSNP
rs1336273639 2251 dbSNP
rs1160456857 2260 dbSNP
rs1415220739 2268 dbSNP
rs891399114 2271 dbSNP
rs1034700146 2272 dbSNP
rs528174124 2278 dbSNP
rs1479326166 2289 dbSNP
rs1037268643 2292 dbSNP
rs898699426 2293 dbSNP
rs1163697704 2297 dbSNP
rs1211621125 2298 dbSNP
rs1239820625 2298 dbSNP
rs1392174170 2310 dbSNP
rs995682373 2311 dbSNP
rs1320409417 2312 dbSNP
rs1327749167 2317 dbSNP
rs1336792698 2319 dbSNP
rs990891600 2336 dbSNP
rs1449423003 2337 dbSNP
rs1313618208 2341 dbSNP
rs1285965488 2345 dbSNP
rs1448871586 2356 dbSNP
rs1405520921 2360 dbSNP
rs182382176 2368 dbSNP
rs1467418686 2371 dbSNP
rs1027824493 2377 dbSNP
rs1247302086 2395 dbSNP
rs1170917439 2412 dbSNP
rs894189329 2424 dbSNP
rs1012555008 2425 dbSNP
rs775317274 2430 dbSNP
rs1242027889 2435 dbSNP
rs1181342773 2444 dbSNP
rs1410271200 2452 dbSNP
rs971023255 2455 dbSNP
rs1458829292 2461 dbSNP
rs1252212402 2462 dbSNP
rs1204277063 2472 dbSNP
rs367812438 2479 dbSNP
rs1031583129 2483 dbSNP
rs760640492 2487 dbSNP
rs989963188 2490 dbSNP
rs1382087791 2495 dbSNP
rs1313074156 2496 dbSNP
rs112056317 2501 dbSNP
rs768584440 2508 dbSNP
rs942749591 2510 dbSNP
rs186723569 2517 dbSNP
rs1461283135 2524 dbSNP
rs986871871 2526 dbSNP
rs1165320503 2535 dbSNP
rs1352614415 2544 dbSNP
rs762190467 2563 dbSNP
rs1425272277 2566 dbSNP
rs1384022810 2567 dbSNP
rs912592618 2570 dbSNP
rs1040096673 2579 dbSNP
rs940035317 2585 dbSNP
rs1441088686 2588 dbSNP
rs1250815464 2591 dbSNP
rs1460019955 2597 dbSNP
rs1176325724 2601 dbSNP
rs1479860590 2604 dbSNP
rs921896987 2608 dbSNP
rs1037723921 2621 dbSNP
rs1167005394 2659 dbSNP
rs898713076 2662 dbSNP
rs1289636033 2699 dbSNP
rs778929483 2714 dbSNP
rs931474827 2731 dbSNP
rs1242419754 2747 dbSNP
rs748170573 2751 dbSNP
rs1306551610 2754 dbSNP
rs894241635 2762 dbSNP
rs1389929646 2770 dbSNP
rs144389445 2777 dbSNP
rs1295091807 2782 dbSNP
rs1405437588 2785 dbSNP
rs375405354 2795 dbSNP
rs906915045 2806 dbSNP
rs191203876 2807 dbSNP
rs1032012427 2811 dbSNP
rs1363944762 2814 dbSNP
rs902363949 2815 dbSNP
rs999277994 2828 dbSNP
rs1416992882 2853 dbSNP
rs1427643960 2858 dbSNP
rs777899987 2865 dbSNP
rs957289722 2873 dbSNP
rs766436893 2874 dbSNP
rs1454000438 2876 dbSNP
rs1028190522 2879 dbSNP
rs896218177 2888 dbSNP
rs1011945351 2894 dbSNP
rs112188145 2899 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 80823.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cccAGGGAGAGGUUUACACAGa 5'
             |: :|||||  ||||||| 
Target 5' -auUUAUUCUCC-UAUGUGUCa 3'
 		1 - 20
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000372735.1 | 3UTR | AUUUAUUCUCCUAUGUGUCAUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000372735.1 | 3UTR | AUUUAUUCUCCUAUGUGUCAUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
77 hsa-miR-642b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082888 ZNF543 zinc finger protein 543 2 2
MIRT108294 BHLHB9 basic helix-loop-helix family member b9 2 2
MIRT348737 ZNF350 zinc finger protein 350 2 2
MIRT381384 EXOG exo/endonuclease G 2 2
MIRT452245 TRAM1 translocation associated membrane protein 1 2 2
MIRT459262 ADRBK1 G protein-coupled receptor kinase 2 2 2
MIRT468117 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468402 SETD3 SET domain containing 3 2 2
MIRT469079 RNF168 ring finger protein 168 2 2
MIRT471690 OXR1 oxidation resistance 1 2 2
MIRT477353 EOGT EGF domain specific O-linked N-acetylglucosamine transferase 2 4
MIRT479600 CDC25B cell division cycle 25B 2 2
MIRT482377 AFF4 AF4/FMR2 family member 4 2 4
MIRT484029 LARP4B La ribonucleoprotein domain family member 4B 2 2
MIRT490988 USP22 ubiquitin specific peptidase 22 2 2
MIRT493250 MEF2D myocyte enhancer factor 2D 2 2
MIRT493850 FOXN3 forkhead box N3 2 4
MIRT496086 C17orf85 nuclear cap binding subunit 3 2 2
MIRT500630 TXNIP thioredoxin interacting protein 2 2
MIRT501048 SMEK1 protein phosphatase 4 regulatory subunit 3A 2 2
MIRT525186 ZNF257 zinc finger protein 257 2 4
MIRT534875 QSER1 glutamine and serine rich 1 2 2
MIRT539336 AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2 2
MIRT553814 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT555959 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT556289 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT561212 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT567328 HMGB1 high mobility group box 1 2 2
MIRT572385 LRRC6 leucine rich repeat containing 6 2 2
MIRT575529 Map4 microtubule-associated protein 4 2 2
MIRT575684 Map1b microtubule-associated protein 1B 2 2
MIRT576828 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT576953 Pigs phosphatidylinositol glycan anchor biosynthesis, class S 2 3
MIRT608316 SYK spleen associated tyrosine kinase 2 4
MIRT609794 PINX1 PIN2/TERF1 interacting telomerase inhibitor 1 2 2
MIRT609991 PIGS phosphatidylinositol glycan anchor biosynthesis class S 2 3
MIRT611381 PNMAL1 paraneoplastic Ma antigen family member 8A 2 4
MIRT613566 YY2 YY2 transcription factor 2 2
MIRT614612 MVK mevalonate kinase 2 2
MIRT615497 MPP2 membrane palmitoylated protein 2 2 2
MIRT616941 OTUD7A OTU deubiquitinase 7A 2 2
MIRT617576 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT618214 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 4
MIRT619885 ABHD17B abhydrolase domain containing 17B 2 2
MIRT620401 MYO1H myosin IH 2 2
MIRT620517 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT622166 SMYD1 SET and MYND domain containing 1 2 2
MIRT623195 MTX3 metaxin 3 2 2
MIRT623440 KIAA0408 KIAA0408 2 4
MIRT624837 ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2 2
MIRT625706 SHROOM1 shroom family member 1 2 2
MIRT628159 HIP1 huntingtin interacting protein 1 2 2
MIRT629496 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT630240 SOGA3 SOGA family member 3 2 4
MIRT630521 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 4
MIRT635676 COX18 COX18, cytochrome c oxidase assembly factor 2 4
MIRT637820 CACNA1B calcium voltage-gated channel subunit alpha1 B 2 2
MIRT637943 SIGLEC9 sialic acid binding Ig like lectin 9 2 2
MIRT640490 EXOC5 exocyst complex component 5 2 2
MIRT642722 ATXN3 ataxin 3 2 2
MIRT649153 LRTM1 leucine rich repeats and transmembrane domains 1 2 2
MIRT649610 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT661016 ABCA12 ATP binding cassette subfamily A member 12 2 2
MIRT661055 RPL18A ribosomal protein L18a 2 2
MIRT684041 FOLR1 folate receptor 1 2 2
MIRT691014 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT698908 SPPL2A signal peptide peptidase like 2A 2 2
MIRT700981 PDE4D phosphodiesterase 4D 2 2
MIRT701722 MTMR12 myotubularin related protein 12 2 2
MIRT702724 INSIG1 insulin induced gene 1 2 2
MIRT705057 C5orf15 chromosome 5 open reading frame 15 2 2
MIRT705216 BRWD1 bromodomain and WD repeat domain containing 1 2 2
MIRT706088 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT709458 KRTAP19-1 keratin associated protein 19-1 2 2
MIRT711396 RANBP2 RAN binding protein 2 2 2
MIRT720573 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT725366 MTF2 metal response element binding transcription factor 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-642b-3p Platinum-based doublet chemotherapy sensitive High Lung Adenocarcinoma tissue
hsa-miR-642b-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-642b-3p Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-642b-3p Sunitinib 5329102 NSC750690 approved resistant Low Renal Cell Cancer cell line (ACHN, RCC23)
hsa-miR-642b-3p Paclitaxel 36314 NSC125973 approved sensitive High Ovarian Cancer cell line (HEYA8)
hsa-miR-642b-3p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-642b-3p Platinum 23939 sensitive High High-Grade Serous Ovarian Cancer tissue
hsa-miR-642b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-642b-3p Platinum-based doublet chemotherapy sensitive tissue (lung adenocarcinoma)
hsa-miR-642b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-642b-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-642b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-642b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVSAHO)

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