miRTarBase - #MIRT110455


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pre-miRNA Information
pre-miRNA hsa-mir-124-1   
Genomic Coordinates chr8: 9903388 - 9903472
Description Homo sapiens miR-124-1 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-2   
Genomic Coordinates chr8: 64379149 - 64379257
Description Homo sapiens miR-124-2 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-3   
Genomic Coordinates chr20: 63178500 - 63178586
Description Homo sapiens miR-124-3 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-124-5p
Sequence 14| CGUGUUCACAGCGGACCUUGAU |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 8 + 64379180 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1280076135 1 dbSNP
rs775858016 4 dbSNP
rs760972715 7 dbSNP
rs1334649236 11 dbSNP
rs1160219511 12 dbSNP
rs764591061 12 dbSNP
rs1261326747 13 dbSNP
rs1344491363 20 dbSNP
rs1340798465 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Peripheral blood mononuclear cell Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol PLEKHA1   
Synonyms TAPP1
Description pleckstrin homology domain containing A1
Transcript NM_001001974   
Other Transcripts NM_021622   
Expression
Putative miRNA Targets on PLEKHA1
3'UTR of PLEKHA1
(miRNA target sites are highlighted)		 
>PLEKHA1|NM_001001974|3'UTR
   1 GGCAGAAGCGCACGGAGCCTGCCTGCCTCTGCCGTCCTCAGTTTCCTTTCATGAGGCTTCTAGCCAAAGATGATAAAGGG
  81 GGAAATGGTTTTTAGTGCGTATATTATACTGCCTCTTAGGTGTACTCTTTATAAGCTGGTAAACCAAGAATCTAGGGAGT
 161 GGCCAAACTAAATATAATTTCTTTAAAAAAGAAAGAAAAAGGAAAAATCCAAAATATCTCAGTATCATCTGTCTGAAGCA
 241 TTGTGTGTTCTCATTCGGGTGGTAACAATGTATGTGTAATATTTTTTTCTTAGTGATTTTGACAGTTTAAATGTTTAACA
 321 ACTTAAAGCATTAAAAATGCTTATTAATAACTTTGGTCATTTAAAAAATGCTACAATGACTTCCTATTAAAGGTTCAATA
 401 TTTACACATTCTTATTGGTTGATATTACCACATGAAATATTGCCAGACCAAGATACCTAAACTCATGATGTCTGTGGTGC
 481 TGTAAAATTTATACTAAAATGTGGACTATTTTGAAATTATAACCATTTTTGATGCCCTGAATCTTGAGGTGACTTATTTT
 561 GCATAGAGGATATGGATAGACCAACAGTAAGGGTTGTGGGTTATACCGGCATAGAGAAAAGAAGAAAACTAGAATTGAAA
 641 CAACTGTGTCTTAGACATTTGTTTGAAAAAGCTTCATCAGGCCTTGGAGCAGTCACTGCTTTATTCCGCAAAAATTATTT
 721 GGTAGGAAATTTTTGGGAGATCTGATTTTCTTATCCAAGTTTTGTAAATAGTTGTTATTTCTATATTTGGATTGGTGAAA
 801 GACCTCAAGTTTATATGTAAAGACATAACTGCCCTTAGTCATGAAATTGTTGTGACCTCTACTTTTTGTCACTAATAGCC
 881 TACATTCAAGTGCCTGTGTTTTTTCATCTTGTTTAGGAATGTTTTGAGATTAATGTGCTTAAAAGTCCTACGTGACTGAT
 961 TTTAAACATTGTGATAAAATTAATTTTCAGTAGAATAGTTGAATGTGTTAAGATAGGATTTTATGTTAGAGATACCAGAA
1041 TGCTGGTATTCTACTACTTGTGCAATATATATGTTTTAAAAAACAAATTTGAGAATACATTTAATCATAGGGATATAGAT
1121 ATAAGCACCTCTCTAAAGAATCTTTAGTTTCCGACGTTGAATTATAGACCAGTTTGAGTAAGTACTGCTTTTTTTTTTTG
1201 GAGACGGGCTCTCGCTCTGTTGCTCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTACAGCCTCCACCTCGTGGGTT
1281 CAAACAGTTGTGCTGCCTCAGCTTCCCGAGTAGCTAGGATTACAGGTGCATGCCACCACACCTGGCTAATTTTTGTATTT
1361 TAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTCGTCTCGAACTCCTGACTTCAGGTGATCCACCCATCTCAGCCTCC
1441 CAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCCCATAAGTACCGTTTTTGAGGTTCAGTCTTAAACATTTGC
1521 TTTAAGAAAACAGTCTTGAATTTCACATGCTGCTATTTTTATATTTTGCCATTTTACAGTACTGTTTTGTTTTGAATTCA
1601 TGCATATCATTGAAAATTTCTCGTTTTCATTTTCTTAGATGACTTCTTGTCTGAGACAGAAAAATTTCCTACTACAGCAG
1681 TGCAGTCCAGAGGTTAAGATGTATTAGAATTATACAATATCAGTTTAAAAATCTGTATGCATAAAGAATGCACCACTCAA
1761 CTTTTTTATTCATAAGCTAATATTTTTTTAAAGTTACATTAAGATTTTTTCTCTTTTGCAGCTACATTTGAAAGTGATAG
1841 AATAAAGAGATTTTAATGAGTTATCACTTTTTCAGCTGATATATTCATTTTAATGGCTTTTTTGAAAGTTCCTTTTTCAT
1921 GAACACACCCGAGAAATCTTAAATAGACACTTTGCAATATTTAAGAACCTAATGCTGTTTAATTTTGGTACAGCTTCCAC
2001 ATTGCATGTTCACTTTAGTATTTGCAATTTGATATATTTCATGGTGGCAAAATATTAGCTCTGTTTTGGGACATTTTAAA
2081 ATAGAACTATCCTTGTTCGATAGCATAGGAAAATGTTCTGGTGATTGTCAGGGTCTCCTAATATTTATCTCAATTCTTTT
2161 ATAAGTCTATGGAAATTATTTAATTATTTTAAAACGTACACACTTTTCTTGTAAATATGTCACATCTGAGTTCAAAAAAA
2241 TTACTTTGAATACCTTAATATTTGCTGCATTTTTTTCCGTATATATAACATGTCTTCTTTCAGAATGGGAATATATGTGT
2321 GCCTCCCAACATTTACTGTTAAAGTGTGTTATCTTTATATGTCAAACTGGTTGAACACTGTAATGAGAATAAACTGCACA
2401 GAGTTTATTCTGACTTAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uagUUCCAGGCGA---CACUUGUGc 5'
             ||| ||| :|    ||||||| 
Target 5' tgaAAGTTCCTTTTTCATGAACACa 3'
 1903 - 1927 155.00 -9.90
2 
miRNA  3' uaguUCCAG-GCGAC--ACUUGUGc 5'
              | |||   |||  ||||||| 
Target 5' ttatATGTCAAACTGGTTGAACACt 3'
 2355 - 2379 148.00 -10.90
3 
miRNA  3' uaguuccaggcGACACUUGUGc 5'
                     || ||||:|| 
Target 5' caaaaaaattaCTTTGAATACc 3'
 2233 - 2254 131.00 -6.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30154183 16 COSMIC
COSN30497892 33 COSMIC
COSN13257903 35 COSMIC
COSN25810120 167 COSMIC
COSN31589696 472 COSMIC
COSN16130360 526 COSMIC
COSN30171071 888 COSMIC
COSN31959534 907 COSMIC
COSN15748230 915 COSMIC
COSN31516890 1053 COSMIC
COSN30391744 1092 COSMIC
COSN30390001 1093 COSMIC
COSN6944444 1153 COSMIC
COSN15365253 1177 COSMIC
COSN24718469 1201 COSMIC
COSN5793900 1249 COSMIC
COSN15662305 1456 COSMIC
COSN31959535 1463 COSMIC
COSN26547907 1473 COSMIC
COSN26647621 1474 COSMIC
COSN26567549 1478 COSMIC
COSN31518687 1479 COSMIC
COSN31583941 1521 COSMIC
COSN31548386 1527 COSMIC
COSN31571813 1616 COSMIC
COSN23469519 1763 COSMIC
COSN31482978 1804 COSMIC
COSN31595862 1886 COSMIC
COSN22119865 2168 COSMIC
COSN22119866 2302 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs948370120 4 dbSNP
rs1329912404 5 dbSNP
rs767145828 8 dbSNP
rs749948712 10 dbSNP
rs755554481 11 dbSNP
rs368778516 14 dbSNP
rs754392607 15 dbSNP
rs755480994 19 dbSNP
rs779176876 20 dbSNP
rs372713152 23 dbSNP
rs1222050229 27 dbSNP
rs1207675180 28 dbSNP
rs1286220444 34 dbSNP
rs1447434716 35 dbSNP
rs892625586 39 dbSNP
rs748497042 40 dbSNP
rs1266348132 41 dbSNP
rs112601954 52 dbSNP
rs990710107 58 dbSNP
rs1387729700 61 dbSNP
rs1173561436 71 dbSNP
rs867664446 73 dbSNP
rs1455638713 76 dbSNP
rs545044725 79 dbSNP
rs879688683 81 dbSNP
rs1246781758 83 dbSNP
rs1022787291 94 dbSNP
rs899856174 99 dbSNP
rs1242593631 100 dbSNP
rs768211177 101 dbSNP
rs1208035862 102 dbSNP
rs980316737 110 dbSNP
rs1228592833 115 dbSNP
rs746225224 121 dbSNP
rs1029548027 123 dbSNP
rs1299781682 125 dbSNP
rs1229039096 148 dbSNP
rs928623484 151 dbSNP
rs564813001 155 dbSNP
rs1300573104 167 dbSNP
rs769516489 170 dbSNP
rs1037152135 180 dbSNP
rs962856028 188 dbSNP
rs1269163555 194 dbSNP
rs779843294 198 dbSNP
rs572045571 202 dbSNP
rs1203951089 203 dbSNP
rs1292082804 209 dbSNP
rs929181037 213 dbSNP
rs1220959095 216 dbSNP
rs1049387808 219 dbSNP
rs1473700084 225 dbSNP
rs887591638 228 dbSNP
rs1276530087 239 dbSNP
rs1205525024 245 dbSNP
rs1358682268 246 dbSNP
rs1007895905 248 dbSNP
rs939622720 257 dbSNP
rs1052679404 258 dbSNP
rs1411034061 260 dbSNP
rs1468518149 264 dbSNP
rs1164974304 265 dbSNP
rs892663000 280 dbSNP
rs1038885383 283 dbSNP
rs1371959457 293 dbSNP
rs34776323 302 dbSNP
rs1310240776 306 dbSNP
rs1391400620 313 dbSNP
rs946855712 317 dbSNP
rs1043837020 318 dbSNP
rs1163267000 322 dbSNP
rs901555311 323 dbSNP
rs1425676506 334 dbSNP
rs1181480194 345 dbSNP
rs7090725 345 dbSNP
rs1371951273 347 dbSNP
rs1410121373 352 dbSNP
rs996810895 352 dbSNP
rs1263111376 353 dbSNP
rs1289359090 354 dbSNP
rs796163712 355 dbSNP
rs561111002 356 dbSNP
rs1237377711 360 dbSNP
rs1031411818 373 dbSNP
rs1223672467 375 dbSNP
rs115416675 377 dbSNP
rs1282955870 380 dbSNP
rs373301606 382 dbSNP
rs1351978091 384 dbSNP
rs1288529635 392 dbSNP
rs1227750368 413 dbSNP
rs41302729 414 dbSNP
rs962590987 416 dbSNP
rs1292359213 426 dbSNP
rs1459885146 429 dbSNP
rs1206201702 433 dbSNP
rs369176236 437 dbSNP
rs974282996 444 dbSNP
rs1158562799 445 dbSNP
rs1435823333 457 dbSNP
rs1022718884 469 dbSNP
rs1189387880 478 dbSNP
rs1368924091 482 dbSNP
rs1183131634 485 dbSNP
rs1432454110 492 dbSNP
rs1264989275 511 dbSNP
rs1192655880 520 dbSNP
rs970213751 526 dbSNP
rs980390187 535 dbSNP
rs928318162 550 dbSNP
rs1391538851 552 dbSNP
rs928864132 562 dbSNP
rs1429970458 564 dbSNP
rs773752287 567 dbSNP
rs762610396 572 dbSNP
rs1389974521 578 dbSNP
rs1336566773 585 dbSNP
rs1232071497 586 dbSNP
rs1341593001 591 dbSNP
rs1312035842 593 dbSNP
rs1244773309 608 dbSNP
rs988433529 609 dbSNP
rs1312986210 612 dbSNP
rs1388850290 619 dbSNP
rs972712671 625 dbSNP
rs918573302 630 dbSNP
rs1344462061 633 dbSNP
rs1368944864 641 dbSNP
rs761745914 645 dbSNP
rs532142899 648 dbSNP
rs1320448728 653 dbSNP
rs17103541 668 dbSNP
rs1390925332 672 dbSNP
rs943200783 673 dbSNP
rs1038959501 677 dbSNP
rs773012415 679 dbSNP
rs901754930 682 dbSNP
rs1465745703 683 dbSNP
rs997162715 684 dbSNP
rs946919300 696 dbSNP
rs1274127636 707 dbSNP
rs1433500087 709 dbSNP
rs565694001 711 dbSNP
rs534467133 715 dbSNP
rs547775683 716 dbSNP
rs760441327 722 dbSNP
rs891431078 725 dbSNP
rs1011744694 729 dbSNP
rs567805851 731 dbSNP
rs190935301 733 dbSNP
rs75277276 735 dbSNP
rs1001690901 740 dbSNP
rs1199329915 743 dbSNP
rs1035970248 744 dbSNP
rs148317227 745 dbSNP
rs972952536 756 dbSNP
rs1349010035 757 dbSNP
rs918593037 761 dbSNP
rs1167433858 762 dbSNP
rs1370921294 769 dbSNP
rs1226825601 771 dbSNP
rs531691631 774 dbSNP
rs370642818 784 dbSNP
rs984649149 791 dbSNP
rs766202306 793 dbSNP
rs1174664300 794 dbSNP
rs1036962981 798 dbSNP
rs1466391884 802 dbSNP
rs41308685 804 dbSNP
rs1166704988 807 dbSNP
rs1452511105 807 dbSNP
rs1335272620 814 dbSNP
rs763218456 816 dbSNP
rs1435829844 818 dbSNP
rs1185071397 819 dbSNP
rs1294948255 820 dbSNP
rs1038823823 831 dbSNP
rs1200676357 844 dbSNP
rs923083890 849 dbSNP
rs933252034 851 dbSNP
rs1344972293 857 dbSNP
rs1023256808 862 dbSNP
rs1053002890 863 dbSNP
rs891495481 866 dbSNP
rs1338741455 874 dbSNP
rs1315185428 875 dbSNP
rs1415613775 880 dbSNP
rs1235767115 885 dbSNP
rs1370122727 890 dbSNP
rs1305956875 891 dbSNP
rs1264111518 892 dbSNP
rs1371143445 916 dbSNP
rs1428952050 935 dbSNP
rs1162554057 937 dbSNP
rs373378845 952 dbSNP
rs1455992926 955 dbSNP
rs947065064 971 dbSNP
rs969871805 974 dbSNP
rs1187573598 975 dbSNP
rs1472064369 979 dbSNP
rs1002652806 1004 dbSNP
rs1344081195 1004 dbSNP
rs1484227176 1013 dbSNP
rs1035419935 1019 dbSNP
rs769590519 1032 dbSNP
rs1354405049 1036 dbSNP
rs1267317198 1051 dbSNP
rs905594872 1062 dbSNP
rs1233902239 1063 dbSNP
rs1269881388 1065 dbSNP
rs1286660282 1065 dbSNP
rs955708078 1070 dbSNP
rs1465297599 1071 dbSNP
rs145790903 1078 dbSNP
rs374067699 1078 dbSNP
rs988855341 1084 dbSNP
rs1322881124 1090 dbSNP
rs1403552490 1091 dbSNP
rs914167366 1107 dbSNP
rs767529118 1111 dbSNP
rs1163370882 1113 dbSNP
rs1001264292 1119 dbSNP
rs1187389506 1123 dbSNP
rs1259131449 1144 dbSNP
rs1409369434 1145 dbSNP
rs1160880634 1147 dbSNP
rs968666304 1153 dbSNP
rs1199181590 1154 dbSNP
rs550334261 1157 dbSNP
rs1198527085 1159 dbSNP
rs1376748547 1159 dbSNP
rs1469569110 1161 dbSNP
rs774812463 1161 dbSNP
rs1450399188 1165 dbSNP
rs895955327 1172 dbSNP
rs994421806 1173 dbSNP
rs1025890759 1175 dbSNP
rs952854064 1179 dbSNP
rs759980290 1184 dbSNP
rs1328538599 1188 dbSNP
rs1491272959 1188 dbSNP
rs1433985172 1189 dbSNP
rs36012040 1189 dbSNP
rs397826975 1189 dbSNP
rs80271676 1190 dbSNP
rs1332786961 1193 dbSNP
rs979706233 1199 dbSNP
rs1174743462 1200 dbSNP
rs77954371 1200 dbSNP
rs201891435 1201 dbSNP
rs76918165 1202 dbSNP
rs764175129 1206 dbSNP
rs140517789 1207 dbSNP
rs1400944004 1209 dbSNP
rs1423946833 1214 dbSNP
rs1172391805 1215 dbSNP
rs1379922331 1218 dbSNP
rs1477215832 1218 dbSNP
rs1194801239 1219 dbSNP
rs1382940439 1225 dbSNP
rs1246281994 1235 dbSNP
rs1388707606 1237 dbSNP
rs751593770 1244 dbSNP
rs757740872 1245 dbSNP
rs912616734 1253 dbSNP
rs1221392877 1254 dbSNP
rs1346818469 1261 dbSNP
rs1304153725 1266 dbSNP
rs1018798827 1271 dbSNP
rs940031541 1274 dbSNP
rs964114881 1275 dbSNP
rs898490873 1283 dbSNP
rs538629753 1292 dbSNP
rs562836477 1294 dbSNP
rs1208083043 1298 dbSNP
rs1249945242 1300 dbSNP
rs143086805 1300 dbSNP
rs370654319 1300 dbSNP
rs1489152945 1302 dbSNP
rs923115071 1308 dbSNP
rs933153797 1309 dbSNP
rs989170469 1322 dbSNP
rs781570256 1327 dbSNP
rs572130624 1328 dbSNP
rs947065325 1330 dbSNP
rs1174594504 1331 dbSNP
rs1449402596 1335 dbSNP
rs1002683815 1338 dbSNP
rs1266156206 1340 dbSNP
rs1479253865 1343 dbSNP
rs1188385782 1358 dbSNP
rs1197707952 1362 dbSNP
rs1035452767 1373 dbSNP
rs1208272009 1379 dbSNP
rs1443982460 1381 dbSNP
rs1280794907 1397 dbSNP
rs541275251 1398 dbSNP
rs905501370 1400 dbSNP
rs937083533 1401 dbSNP
rs150400781 1402 dbSNP
rs1159063620 1403 dbSNP
rs1343976919 1408 dbSNP
rs1459462120 1410 dbSNP
rs896024229 1417 dbSNP
rs994337704 1421 dbSNP
rs1429463888 1423 dbSNP
rs1369302670 1428 dbSNP
rs1173121745 1441 dbSNP
rs1410666008 1444 dbSNP
rs111477601 1452 dbSNP
rs1026342984 1456 dbSNP
rs888685195 1457 dbSNP
rs1476311495 1458 dbSNP
rs11200626 1459 dbSNP
rs1181213884 1460 dbSNP
rs756512090 1461 dbSNP
rs574567357 1462 dbSNP
rs1018288065 1463 dbSNP
rs963978699 1469 dbSNP
rs867989160 1476 dbSNP
rs1029695169 1478 dbSNP
rs1320986360 1479 dbSNP
rs1028514840 1484 dbSNP
rs1229499011 1492 dbSNP
rs954231539 1493 dbSNP
rs1287304384 1495 dbSNP
rs1223035134 1500 dbSNP
rs780626872 1500 dbSNP
rs1349008189 1505 dbSNP
rs1304725141 1525 dbSNP
rs1443577647 1528 dbSNP
rs1349738474 1533 dbSNP
rs1323448235 1535 dbSNP
rs954573359 1537 dbSNP
rs1162806341 1540 dbSNP
rs988643587 1562 dbSNP
rs1290482344 1582 dbSNP
rs1158665942 1589 dbSNP
rs1471521273 1590 dbSNP
rs912647942 1594 dbSNP
rs913035304 1600 dbSNP
rs1488135628 1604 dbSNP
rs1206906542 1609 dbSNP
rs1254378338 1610 dbSNP
rs940137022 1614 dbSNP
rs1334891063 1615 dbSNP
rs1483563040 1620 dbSNP
rs947341208 1623 dbSNP
rs529636259 1624 dbSNP
rs11539386 1625 dbSNP
rs1226169317 1635 dbSNP
rs972832685 1636 dbSNP
rs919949866 1637 dbSNP
rs543298905 1638 dbSNP
rs1224645103 1669 dbSNP
rs1177008342 1670 dbSNP
rs1406342284 1674 dbSNP
rs1426146546 1686 dbSNP
rs931312160 1695 dbSNP
rs563375793 1697 dbSNP
rs532211377 1698 dbSNP
rs936985685 1702 dbSNP
rs1056934226 1703 dbSNP
rs1165556333 1704 dbSNP
rs1292268617 1713 dbSNP
rs1384739396 1714 dbSNP
rs1443247609 1716 dbSNP
rs1395294336 1717 dbSNP
rs138342268 1718 dbSNP
rs930157665 1723 dbSNP
rs905748671 1724 dbSNP
rs938504409 1734 dbSNP
rs559344454 1738 dbSNP
rs1195424398 1739 dbSNP
rs1468576505 1743 dbSNP
rs888584281 1745 dbSNP
rs1246892175 1752 dbSNP
rs1005809084 1757 dbSNP
rs1039892746 1759 dbSNP
rs1260896211 1761 dbSNP
rs1217015529 1765 dbSNP
rs1441141172 1766 dbSNP
rs1296243227 1767 dbSNP
rs1381244130 1776 dbSNP
rs899878972 1780 dbSNP
rs998130431 1781 dbSNP
rs1432931240 1782 dbSNP
rs1387481105 1783 dbSNP
rs748895189 1795 dbSNP
rs1465420932 1800 dbSNP
rs1010435833 1807 dbSNP
rs1313701535 1810 dbSNP
rs1175215952 1820 dbSNP
rs1454656700 1825 dbSNP
rs1356694338 1827 dbSNP
rs956831375 1838 dbSNP
rs1186147135 1846 dbSNP
rs1429749690 1847 dbSNP
rs1262041449 1850 dbSNP
rs1199521783 1851 dbSNP
rs1021364120 1860 dbSNP
rs142724785 1863 dbSNP
rs976305405 1868 dbSNP
rs1010039805 1875 dbSNP
rs1020127317 1880 dbSNP
rs377350911 1882 dbSNP
rs968919472 1883 dbSNP
rs1204264734 1892 dbSNP
rs536504236 1898 dbSNP
rs200299076 1905 dbSNP
rs1344095103 1909 dbSNP
rs1296638561 1913 dbSNP
rs1395680154 1914 dbSNP
rs1377160660 1925 dbSNP
rs181776797 1931 dbSNP
rs1184793730 1932 dbSNP
rs954254413 1938 dbSNP
rs927184679 1944 dbSNP
rs1463129118 1946 dbSNP
rs958385725 1947 dbSNP
rs1373138994 1949 dbSNP
rs987007633 1957 dbSNP
rs768431476 1969 dbSNP
rs1259121368 1975 dbSNP
rs1019773129 1983 dbSNP
rs1486187099 1984 dbSNP
rs1170583089 1989 dbSNP
rs992474190 1991 dbSNP
rs961554420 1995 dbSNP
rs1342008606 1998 dbSNP
rs1409672843 2000 dbSNP
rs548057923 2001 dbSNP
rs916894625 2003 dbSNP
rs571434328 2005 dbSNP
rs1466454082 2007 dbSNP
rs1295323893 2017 dbSNP
rs1415212104 2032 dbSNP
rs929753714 2033 dbSNP
rs1047217690 2035 dbSNP
rs1326838520 2038 dbSNP
rs1393072538 2045 dbSNP
rs910053959 2056 dbSNP
rs941518046 2062 dbSNP
rs1455915906 2063 dbSNP
rs1419628395 2071 dbSNP
rs778449237 2074 dbSNP
rs567909560 2078 dbSNP
rs536830854 2086 dbSNP
rs1475774083 2089 dbSNP
rs1039961844 2090 dbSNP
rs550139107 2092 dbSNP
rs900076950 2095 dbSNP
rs1297699534 2099 dbSNP
rs980066524 2100 dbSNP
rs998370652 2129 dbSNP
rs1467167627 2130 dbSNP
rs1275356390 2144 dbSNP
rs1360822113 2147 dbSNP
rs1328680856 2151 dbSNP
rs1277587205 2154 dbSNP
rs1240860531 2157 dbSNP
rs927199228 2159 dbSNP
rs1322778872 2160 dbSNP
rs569934437 2162 dbSNP
rs747635669 2164 dbSNP
rs1057064575 2174 dbSNP
rs892428732 2176 dbSNP
rs1271284722 2180 dbSNP
rs891654083 2187 dbSNP
rs1314272355 2192 dbSNP
rs538723005 2196 dbSNP
rs1043218018 2197 dbSNP
rs1009659410 2199 dbSNP
rs904245369 2200 dbSNP
rs1263005613 2203 dbSNP
rs1452724012 2214 dbSNP
rs143836607 2216 dbSNP
rs968613068 2231 dbSNP
rs1464632303 2237 dbSNP
rs1282395442 2258 dbSNP
rs538861544 2264 dbSNP
rs1351121960 2270 dbSNP
rs35693677 2270 dbSNP
rs1274241678 2271 dbSNP
rs1475193346 2277 dbSNP
rs534750326 2280 dbSNP
rs1303551455 2286 dbSNP
rs1433653911 2290 dbSNP
rs958628769 2291 dbSNP
rs1433504217 2293 dbSNP
rs770699048 2295 dbSNP
rs1402877858 2301 dbSNP
rs1386118026 2311 dbSNP
rs961862735 2314 dbSNP
rs1173343123 2316 dbSNP
rs1453122284 2327 dbSNP
rs1397374301 2328 dbSNP
rs776423967 2330 dbSNP
rs1194400827 2332 dbSNP
rs994317796 2338 dbSNP
rs1240645424 2342 dbSNP
rs1403728962 2347 dbSNP
rs1458811472 2355 dbSNP
rs1447736499 2357 dbSNP
rs1277656610 2358 dbSNP
rs992714299 2366 dbSNP
rs1349996224 2369 dbSNP
rs952788548 2371 dbSNP
rs916928677 2374 dbSNP
rs1320615724 2379 dbSNP
rs1359251732 2379 dbSNP
rs951079002 2390 dbSNP
rs1271632709 2400 dbSNP
rs1344133043 2400 dbSNP
rs982591746 2406 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uaguuccAGGCGA---CACUUGUGc 5'
                 ||| :|    ||||||| 
Target 5' ------uUCCUUUUUCAUGAACACa 3'
 		1 - 19
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000538022.1 | 3UTR | UUCCUUUUUCAUGAACACACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.575 1.6e-3 -0.506 5.8e-3 24 Click to see details
GSE19350 CNS germ cell tumors -0.768 1.8e-3 -0.301 1.7e-1 12 Click to see details
GSE21687 Ependynoma primary tumors 0.306 7.0e-3 -0.011 4.7e-1 64 Click to see details
GSE32688 Pancreatic cancer -0.411 9.7e-3 -0.400 1.2e-2 32 Click to see details
GSE17498 Multiple myeloma 0.268 4.7e-2 0.336 1.7e-2 40 Click to see details
GSE42095 Differentiated embryonic stem cells -0.343 5.5e-2 -0.145 2.5e-1 23 Click to see details
GSE28260 Renal cortex and medulla 0.213 2.4e-1 0.220 2.4e-1 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.137 2.6e-1 0.154 2.3e-1 25 Click to see details
GSE38226 Liver fibrosis 0.148 2.6e-1 0.145 2.7e-1 21 Click to see details
GSE26953 Aortic valvular endothelial cells -0.037 4.3e-1 0.071 3.7e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.022 4.6e-1 0.044 4.3e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.022 4.6e-1 0.044 4.3e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
0.022 4.6e-1 0.044 4.3e-1 20 Click to see details
0.022 4.6e-1 0.044 4.3e-1 20 Click to see details
0.022 4.6e-1 0.044 4.3e-1 20 Click to see details
65 hsa-miR-124-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064177 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT069736 FOXG1 forkhead box G1 2 4
MIRT086429 NABP1 nucleic acid binding protein 1 2 6
MIRT105334 SLC7A2 solute carrier family 7 member 2 2 4
MIRT110455 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT172998 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT196428 TAOK1 TAO kinase 1 2 14
MIRT325704 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT365670 TSC22D3 TSC22 domain family member 3 2 4
MIRT365873 XIAP X-linked inhibitor of apoptosis 2 2
MIRT404126 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT404626 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT405284 ARF1 ADP ribosylation factor 1 2 2
MIRT406099 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT446627 SDC3 syndecan 3 2 2
MIRT446906 RGS5 regulator of G protein signaling 5 2 2
MIRT461790 FXR2 FMR1 autosomal homolog 2 2 2
MIRT463982 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT464204 VGLL4 vestigial like family member 4 2 2
MIRT472790 MTMR4 myotubularin related protein 4 2 4
MIRT473485 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT481124 AZIN1 antizyme inhibitor 1 2 4
MIRT485060 SUCO SUN domain containing ossification factor 2 2
MIRT487343 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT491948 VPS52 VPS52, GARP complex subunit 2 2
MIRT497208 CDH7 cadherin 7 2 2
MIRT497476 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT528203 NELFE negative elongation factor complex member E 2 2
MIRT529255 TRIM4 tripartite motif containing 4 2 4
MIRT530096 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530597 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT534980 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT538326 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT561237 ZNF652 zinc finger protein 652 2 2
MIRT562035 KRAS KRAS proto-oncogene, GTPase 2 2
MIRT563120 THAP5 THAP domain containing 5 2 2
MIRT563538 RBM41 RNA binding motif protein 41 2 2
MIRT566037 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT566505 PAWR pro-apoptotic WT1 regulator 2 2
MIRT566745 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT566850 LRRC58 leucine rich repeat containing 58 2 2
MIRT568077 CELF2 CUGBP Elav-like family member 2 2 2
MIRT576826 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT608870 NR2E1 nuclear receptor subfamily 2 group E member 1 2 4
MIRT611997 VAC14 Vac14, PIKFYVE complex component 2 2
MIRT614054 FAM89A family with sequence similarity 89 member A 2 2
MIRT618800 SPATA21 spermatogenesis associated 21 2 2
MIRT619389 RSPH3 radial spoke head 3 homolog 2 2
MIRT622282 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624026 EN2 engrailed homeobox 2 2 2
MIRT626000 MPEG1 macrophage expressed 1 2 2
MIRT641792 USP32 ubiquitin specific peptidase 32 2 2
MIRT651599 WDFY2 WD repeat and FYVE domain containing 2 2 2
MIRT659662 CDC73 cell division cycle 73 2 2
MIRT663010 KIAA1586 KIAA1586 2 2
MIRT663561 ASTN2 astrotactin 2 2 2
MIRT669312 C16orf72 chromosome 16 open reading frame 72 2 2
MIRT685216 POTED POTE ankyrin domain family member D 2 2
MIRT695757 ZNF117 zinc finger protein 117 2 2
MIRT697909 TXNRD1 thioredoxin reductase 1 2 2
MIRT707181 RPH3A rabphilin 3A 2 2
MIRT707214 TRIM13 tripartite motif containing 13 2 2
MIRT707478 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT719507 LMAN2L lectin, mannose binding 2 like 2 2
MIRT755814 PARP1 poly(ADP-ribose) polymerase 1 2 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-124 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated
miR-124 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-124 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-124 Cocaine NULL 446220 Quantitative real-time PCR HEK293 cells or rat brain parts 19703567 2009 down-regulated
miR-124 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-124 Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 up-regualted
miR-124 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-124 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (MGC803)
hsa-miR-124-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-124-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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