miRTarBase - #MIRT114494


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pre-miRNA Information
pre-miRNA hsa-mir-3679   
Genomic Coordinates chr2: 134127125 - 134127192
Description Homo sapiens miR-3679 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3679-5p
Sequence 6| UGAGGAUAUGGCAGGGAAGGGGA |28
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 17 2 + 134127146 26487287 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN28578769 23 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1490236859 15 dbSNP
rs982355045 16 dbSNP
rs1053094244 17 dbSNP
rs893220051 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PNN   
Synonyms DRS, DRSP, SDK3, memA
Description pinin, desmosome associated protein
Transcript NM_002687   
Expression
Putative miRNA Targets on PNN
3'UTR of PNN
(miRNA target sites are highlighted)		 
>PNN|NM_002687|3'UTR
   1 TGGAAGAAGCCAGGCTTTCTTAGCCATTCTTTGCAGCAGAAGATTTCTTGATAAAAAAGGATTACCTTTCCTTGTAAAGA
  81 GGATGCTGCCTTAAGAATTGCATGTTGTAAAAAATCTTTTTGGAAAATACAGACTGTTTGTTTACCAGACATTCTTGTAC
 161 TTTTTGCATAATTTTGTAAGAGTTATTTATCAAAATTATGTGAGGTTCCAAAATATGTAAAAATGATAATAATAAAAAAA
 241 GATTAACATCCCTTGTCATCTTTTTTAAATATCCTATACTCTTCAGTAAGAATCTGTATATTTTAATAGGCAAATCTTTA
 321 AGTCTGTTCCCTTCTAATTCTGTATCATACATTGCTTTTGTAGAAATAAATGTGTGTTTATTTCATTATTTTTGGGATGT
 401 CCTCGTTGACACTTGTATAATAAATATCCTCTTTATCATTTTCAGCTTTTAACACTAGATACTGCACGTGATTAGAATGT
 481 TTTTGAAGGTTTCCTCGTTTTTATTTGCCTTGGACAGTTTTTAGTTGTCAGAGTCAGAGCTTTGCAGCTTTGAGGGGGAA
 561 CAGTTCTCTTTAAAATCATTTGCTATTTTCTATTCTCCCTTGTTATTTTAATCTAAGCATTTTCCCCCGTTTCTCATATT
 641 TTAACCATATGTTCGGTAGATAACTAAACAGTATGATCTGGTTGGCATTTTCTTCCTGATGATGGGAGCGTCATTCTTTT
 721 GTCTTCATGGTTACTTGTGTGATATAACATACATCTGTTAAAGAAAATCACTTCTTTCTAGGGGAGGGAGGTAGAAAAGT
 801 ATCTTTCAAACTTGGTTTTTGAGTTTGTGTCTTGTCTTAACTTTGTGTTGGCTCTAACTTAAACATGCTGATATGTGTTT
 881 TCAAGAATTTTGTTTAAGGAAGTATTGTATGGAAGTCCACAAAATGAAGGAAGTTCATCTAGGTTTTAATATGTAAGCAA
 961 GATAACACACAAGTGTACCAAGTGATTATTAACTTTGTTGTTTTACAAATTTGTATGAACTTGGAGTATCTGTTGGCCAT
1041 TACTATACATGTGCAAATAAATGTGGCTTAGACTTGTGTGACTGCTTAAGACTAGTACTTGTATTAACTTTCTGATGCTT
1121 TATACAAGAGAGCACTTAAATTGCATCCTTCTTTGAGTTTAACACTGTAGCTTTAGCCTTGACTTTGAATATTCATTTTG
1201 CCTTCCCTTGACAAGTAAATGGTTACAGTGAAAATGTGAAGAAGTATTTCCAGTTAGTTTTTGTGTGTATATAACTCACT
1281 TGTGTAAGTGGATGTGTTAAAAGATCTCTTTTTAAAAATCCTTTTATTGGAGTAATTATTAAAACAGTAAATGCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agGGGAAGGGACGG--UAUAGGAGu 5'
            | ||| : |  :  |||||||| 
Target 5' gaCACTTGTATAATAAATATCCTCt 3'
 408 - 432 147.00 -12.30
2 
miRNA  3' aggggaAGGGACGGUAUAGGAGu 5'
                |:::||  ||:||||| 
Target 5' tcattaTTTTTGGGATGTCCTCg 3'
 383 - 405 141.00 -15.30
3 
miRNA  3' aggGGAAGGGACGGUAUAGGAgu 5'
             :|||:::|   |||||||  
Target 5' tcaTCTTTTTT-AAATATCCTat 3'
 256 - 277 135.00 -12.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31552767 43 COSMIC
COSN31508226 61 COSMIC
COSN27898253 88 COSMIC
COSN26497202 118 COSMIC
COSN31548439 291 COSMIC
COSN31538236 378 COSMIC
COSN29362659 439 COSMIC
COSN31546435 502 COSMIC
COSN16132040 591 COSMIC
COSN1647011 714 COSMIC
COSN19132918 714 COSMIC
COSN30545011 797 COSMIC
COSN32064889 800 COSMIC
COSN28652370 1153 COSMIC
COSN20120214 1304 COSMIC
COSN20111220 1325 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs775898791 7 dbSNP
rs747376898 13 dbSNP
rs768950912 19 dbSNP
rs777143837 20 dbSNP
rs965756259 22 dbSNP
rs370398078 23 dbSNP
rs1319299469 24 dbSNP
rs766231283 27 dbSNP
rs1210881247 36 dbSNP
rs768187455 38 dbSNP
rs764689971 39 dbSNP
rs571371089 41 dbSNP
rs762567964 42 dbSNP
rs1308953432 44 dbSNP
rs1236725632 45 dbSNP
rs751201343 46 dbSNP
rs767384547 48 dbSNP
rs1301312896 50 dbSNP
rs762749389 52 dbSNP
rs934698905 53 dbSNP
rs1804768 54 dbSNP
rs1194805775 71 dbSNP
rs150671351 72 dbSNP
rs201397104 78 dbSNP
rs954282481 78 dbSNP
rs984130524 80 dbSNP
rs1379846819 82 dbSNP
rs547232640 96 dbSNP
rs1177482084 103 dbSNP
rs777174032 107 dbSNP
rs555875638 109 dbSNP
rs1393417542 114 dbSNP
rs961474186 117 dbSNP
rs532 127 dbSNP
rs950108033 132 dbSNP
rs538234283 135 dbSNP
rs1256494351 150 dbSNP
rs754748869 152 dbSNP
rs1345115829 155 dbSNP
rs1363947261 171 dbSNP
rs1299191583 177 dbSNP
rs1382753010 177 dbSNP
rs1277512225 179 dbSNP
rs1338095466 181 dbSNP
rs1325520956 188 dbSNP
rs75406221 194 dbSNP
rs1380860689 198 dbSNP
rs1404869595 199 dbSNP
rs949960487 200 dbSNP
rs1044232100 210 dbSNP
rs1234909109 211 dbSNP
rs1170592245 216 dbSNP
rs1475844513 217 dbSNP
rs1372692771 218 dbSNP
rs905818779 220 dbSNP
rs1191365414 223 dbSNP
rs1425321906 225 dbSNP
rs1256682895 226 dbSNP
rs1293464022 226 dbSNP
rs1484662127 227 dbSNP
rs1276102387 229 dbSNP
rs1268029758 234 dbSNP
rs1338237073 234 dbSNP
rs927203371 234 dbSNP
rs935897514 234 dbSNP
rs1342565995 235 dbSNP
rs1320805701 237 dbSNP
rs994715295 238 dbSNP
rs1374208131 241 dbSNP
rs1048845146 245 dbSNP
rs1218738032 248 dbSNP
rs886284979 251 dbSNP
rs1054061104 252 dbSNP
rs1459645985 253 dbSNP
rs1186994805 255 dbSNP
rs891437267 261 dbSNP
rs1004563042 273 dbSNP
rs1263143879 277 dbSNP
rs1436713987 280 dbSNP
rs1270274613 281 dbSNP
rs1211202260 286 dbSNP
rs1356645391 294 dbSNP
rs1477009813 295 dbSNP
rs1274159448 299 dbSNP
rs1233027642 301 dbSNP
rs1354012913 311 dbSNP
rs1040127853 314 dbSNP
rs901585665 335 dbSNP
rs1443646668 338 dbSNP
rs1018717286 345 dbSNP
rs1326951416 347 dbSNP
rs901494731 348 dbSNP
rs995892922 353 dbSNP
rs1164540853 364 dbSNP
rs1459666245 370 dbSNP
rs535753761 371 dbSNP
rs762634616 373 dbSNP
rs1028992239 375 dbSNP
rs1190532445 376 dbSNP
rs1230624168 385 dbSNP
rs1250123450 387 dbSNP
rs1468570435 388 dbSNP
rs954282601 389 dbSNP
rs1005785719 390 dbSNP
rs1017181167 394 dbSNP
rs1270426838 405 dbSNP
rs979017278 405 dbSNP
rs752507240 406 dbSNP
rs1278335617 409 dbSNP
rs1438674549 412 dbSNP
rs556060933 413 dbSNP
rs1371892029 417 dbSNP
rs956211309 418 dbSNP
rs1390487534 419 dbSNP
rs1438986073 419 dbSNP
rs575541223 420 dbSNP
rs1400004682 427 dbSNP
rs1346984653 428 dbSNP
rs538284824 429 dbSNP
rs557783889 430 dbSNP
rs1454325320 432 dbSNP
rs972723881 432 dbSNP
rs1191291458 435 dbSNP
rs1465987840 438 dbSNP
rs1244148454 442 dbSNP
rs1216913400 443 dbSNP
rs1446834188 444 dbSNP
rs139918138 455 dbSNP
rs971464351 456 dbSNP
rs917374325 460 dbSNP
rs1313329861 461 dbSNP
rs371204121 468 dbSNP
rs540004585 469 dbSNP
rs1289712308 474 dbSNP
rs1429745333 476 dbSNP
rs935937229 482 dbSNP
rs980086012 497 dbSNP
rs927291987 498 dbSNP
rs758757250 510 dbSNP
rs1316946243 517 dbSNP
rs778130908 522 dbSNP
rs1450835602 524 dbSNP
rs747075298 535 dbSNP
rs1185629882 536 dbSNP
rs1475288850 537 dbSNP
rs770980165 538 dbSNP
rs931722777 539 dbSNP
rs1285864240 547 dbSNP
rs781584682 553 dbSNP
rs556642598 554 dbSNP
rs886252322 559 dbSNP
rs940559055 569 dbSNP
rs1279649118 570 dbSNP
rs1005712339 572 dbSNP
rs765780786 572 dbSNP
rs1040521412 576 dbSNP
rs901633383 579 dbSNP
rs1214278978 581 dbSNP
rs1359525709 586 dbSNP
rs1285747866 591 dbSNP
rs1415271775 593 dbSNP
rs1354779078 595 dbSNP
rs577962588 596 dbSNP
rs1028624881 598 dbSNP
rs1213467166 612 dbSNP
rs1238459129 622 dbSNP
rs1024273465 624 dbSNP
rs903534739 628 dbSNP
rs1180293215 629 dbSNP
rs1000427340 630 dbSNP
rs1033286138 633 dbSNP
rs1257411835 639 dbSNP
rs559935595 648 dbSNP
rs187275749 650 dbSNP
rs1158183182 651 dbSNP
rs542539896 655 dbSNP
rs746338421 656 dbSNP
rs1233649980 657 dbSNP
rs1334540335 657 dbSNP
rs562840178 659 dbSNP
rs1373347444 661 dbSNP
rs1297123725 667 dbSNP
rs1439515574 670 dbSNP
rs971470803 671 dbSNP
rs1358311862 678 dbSNP
rs531202820 686 dbSNP
rs1299460429 688 dbSNP
rs976167238 693 dbSNP
rs1417679415 699 dbSNP
rs922940262 700 dbSNP
rs927292009 704 dbSNP
rs1352113915 709 dbSNP
rs551408445 710 dbSNP
rs770263653 711 dbSNP
rs1479723311 713 dbSNP
rs1279985590 714 dbSNP
rs984657949 717 dbSNP
rs775874437 720 dbSNP
rs1214622388 721 dbSNP
rs564942185 738 dbSNP
rs527405313 740 dbSNP
rs897417457 741 dbSNP
rs1317478960 744 dbSNP
rs560351009 744 dbSNP
rs940527920 746 dbSNP
rs1372616002 749 dbSNP
rs1326166252 752 dbSNP
rs1439713961 753 dbSNP
rs1234801051 772 dbSNP
rs1458436260 774 dbSNP
rs545250203 775 dbSNP
rs763289825 789 dbSNP
rs547544978 790 dbSNP
rs1364850165 798 dbSNP
rs931722775 800 dbSNP
rs1159087464 804 dbSNP
rs907223493 810 dbSNP
rs1173050658 820 dbSNP
rs1194435398 826 dbSNP
rs771723201 826 dbSNP
rs1250863420 828 dbSNP
rs149425102 828 dbSNP
rs1371020650 835 dbSNP
rs1206641528 836 dbSNP
rs1486099225 839 dbSNP
rs957449020 840 dbSNP
rs1011372443 841 dbSNP
rs1303522461 844 dbSNP
rs1000568076 848 dbSNP
rs967286931 853 dbSNP
rs1400573523 859 dbSNP
rs536087060 860 dbSNP
rs1054710229 868 dbSNP
rs1288727790 869 dbSNP
rs1377298580 871 dbSNP
rs976050360 871 dbSNP
rs1174371443 874 dbSNP
rs760133939 875 dbSNP
rs1428893489 880 dbSNP
rs1260784608 884 dbSNP
rs1203252289 885 dbSNP
rs1486624291 885 dbSNP
rs1280371719 886 dbSNP
rs1372485178 896 dbSNP
rs1010911756 902 dbSNP
rs1252694751 902 dbSNP
rs1275897533 909 dbSNP
rs1367587550 912 dbSNP
rs113767289 918 dbSNP
rs1357879146 921 dbSNP
rs1314074068 926 dbSNP
rs1196771206 937 dbSNP
rs569537319 944 dbSNP
rs1318842517 950 dbSNP
rs1001606253 952 dbSNP
rs1256435094 953 dbSNP
rs1469828825 954 dbSNP
rs1462700319 955 dbSNP
rs1372239895 959 dbSNP
rs1199693419 961 dbSNP
rs1246045230 963 dbSNP
rs908967631 979 dbSNP
rs1034422549 988 dbSNP
rs1476090471 989 dbSNP
rs1258116068 991 dbSNP
rs1187210220 994 dbSNP
rs1484364870 995 dbSNP
rs952040987 997 dbSNP
rs984798734 1001 dbSNP
rs753261873 1011 dbSNP
rs907885495 1014 dbSNP
rs537808321 1016 dbSNP
rs1217159051 1020 dbSNP
rs941724824 1022 dbSNP
rs961903208 1027 dbSNP
rs1168005334 1036 dbSNP
rs1038558801 1040 dbSNP
rs976419164 1047 dbSNP
rs1396007794 1049 dbSNP
rs923107239 1063 dbSNP
rs1462809122 1081 dbSNP
rs1418308587 1089 dbSNP
rs931831384 1090 dbSNP
rs1050170460 1093 dbSNP
rs1349778232 1098 dbSNP
rs1181863971 1107 dbSNP
rs1436770277 1109 dbSNP
rs1421078707 1111 dbSNP
rs1215248827 1125 dbSNP
rs192219353 1126 dbSNP
rs553799818 1133 dbSNP
rs936408685 1137 dbSNP
rs1281825095 1146 dbSNP
rs773594960 1152 dbSNP
rs2737721 1153 dbSNP
rs1329560005 1157 dbSNP
rs1001583210 1166 dbSNP
rs1276477181 1173 dbSNP
rs1056161860 1174 dbSNP
rs892148258 1178 dbSNP
rs1403433596 1204 dbSNP
rs1410040168 1206 dbSNP
rs1159134820 1215 dbSNP
rs1469176107 1228 dbSNP
rs1169729752 1231 dbSNP
rs1377951456 1244 dbSNP
rs1195051917 1247 dbSNP
rs542381678 1251 dbSNP
rs766673321 1252 dbSNP
rs1046426176 1264 dbSNP
rs1450296371 1267 dbSNP
rs1210508347 1268 dbSNP
rs534006088 1274 dbSNP
rs1286945191 1281 dbSNP
rs907352725 1287 dbSNP
rs1349970581 1304 dbSNP
rs893234862 1306 dbSNP
rs1289298104 1307 dbSNP
rs1002141873 1313 dbSNP
rs1020306210 1314 dbSNP
rs967211812 1315 dbSNP
rs1034396181 1317 dbSNP
rs567815479 1325 dbSNP
rs1030286036 1331 dbSNP
rs9322995 1336 dbSNP
rs985824225 1338 dbSNP
rs908851399 1340 dbSNP
rs1394082099 1346 dbSNP
rs573742615 1355 dbSNP
rs963143806 1356 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 5411.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aggggaagggacggUAUAGGAGu 5'
                        |||||||| 
Target 5' --------------AUAUCCUCu 3'
 		1 - 9
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000216832.4 | 3UTR | AUAUCCUCUUUAUCAUUUUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.999 0.01 1.000 0.5 3 Click to see details
THCA -0.989 0.05 -1.000 0.5 3 Click to see details
LUSC 0.78 0.22 1.000 0.5 3 Click to see details
HNSC -0.356 0.38 -0.500 0.33 3 Click to see details
HNSC -0.356 0.38 -0.500 0.33 3 Click to see details
HNSC -0.356 0.38 -0.500 0.33 3 Click to see details
HNSC -0.356 0.38 -0.500 0.33 3 Click to see details
HNSC -0.356 0.38 -0.500 0.33 3 Click to see details
HNSC -0.356 0.38 -0.500 0.33 3 Click to see details
55 hsa-miR-3679-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT114494 PNN pinin, desmosome associated protein 2 2
MIRT169967 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 6
MIRT182181 POU2F1 POU class 2 homeobox 1 2 2
MIRT189380 TXLNA taxilin alpha 2 4
MIRT364735 TOR1B torsin family 1 member B 2 2
MIRT445477 KDM6A lysine demethylase 6A 2 2
MIRT446333 ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 2 2
MIRT446386 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT446971 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT449793 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT451211 PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 2 2
MIRT452098 NUCB2 nucleobindin 2 2 2
MIRT454036 DDT D-dopachrome tautomerase 2 2
MIRT461708 ZNF426 zinc finger protein 426 2 2
MIRT464957 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT465775 TMOD3 tropomodulin 3 2 2
MIRT466925 STC2 stanniocalcin 2 2 2
MIRT471388 PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2 2
MIRT473585 MAT2A methionine adenosyltransferase 2A 2 2
MIRT476070 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT477324 EPHA2 EPH receptor A2 2 2
MIRT478244 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT480449 C16orf72 chromosome 16 open reading frame 72 2 6
MIRT481866 ANKRD50 ankyrin repeat domain 50 2 2
MIRT492032 TSG101 tumor susceptibility 101 2 4
MIRT493737 GRAP2 GRB2-related adaptor protein 2 2 2
MIRT495623 PPP1R1C protein phosphatase 1 regulatory inhibitor subunit 1C 2 2
MIRT497590 SLC23A1 solute carrier family 23 member 1 2 2
MIRT504702 ZNF117 zinc finger protein 117 2 2
MIRT507794 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT510653 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT525534 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT531149 CYGB cytoglobin 2 2
MIRT536003 MED13 mediator complex subunit 13 2 2
MIRT537056 GPR180 G protein-coupled receptor 180 2 2
MIRT538297 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT544755 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT544927 MIS18BP1 MIS18 binding protein 1 2 2
MIRT556973 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT561714 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT563632 ZNF460 zinc finger protein 460 2 2
MIRT564705 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT572190 CALU calumenin 2 2
MIRT573900 MKI67 marker of proliferation Ki-67 2 2
MIRT576073 Poteg POTE ankyrin domain family, member G 2 2
MIRT576150 Hmox1 heme oxygenase 1 2 2
MIRT614848 PLEKHA6 pleckstrin homology domain containing A6 2 4
MIRT647592 FAM109B family with sequence similarity 109 member B 2 2
MIRT657009 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT691268 GET4 golgi to ER traffic protein 4 2 2
MIRT695778 DENR density regulated re-initiation and release factor 2 2
MIRT698089 TPM1 tropomyosin 1 2 2
MIRT732571 IGLL5 immunoglobulin lambda like polypeptide 5 1 0
MIRT733722 NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 3 0
MIRT734354 GREM1 gremlin 1, DAN family BMP antagonist 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3679-5p 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3679 Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-3679-5p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3679-5p Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-3679-5p Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-3679-5p Osimertinib 71496458 NSC779217 approved resistant Low Non-Small Cell Lung Cancer tissue
hsa-miR-3679-5p Etoposide 36462 NSC141540 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-3679-5p Doxorubicin 31703 NSC123127 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-3679-5p Paclitaxel 36314 NSC125973 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-3679-5p Vinorelbine 44424639 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-3679-5p Vincristine 5978 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-3679-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-3679-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-3679-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-3679-5p Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-3679-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3679-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3679-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-3679-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3679-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)

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