miRTarBase - #MIRT117671


—
pre-miRNA Information
pre-miRNA hsa-mir-4524a   
Genomic Coordinates chr17: 69099564 - 69099632
Description Homo sapiens miR-4524a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4524a-5p
Sequence 6| AUAGCAGCAUGAACCUGUCUCA |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322445998 8 dbSNP
rs1350790266 13 dbSNP
rs1263495678 21 dbSNP
Putative Targets

Gene Information
Gene Symbol SCAMP4   
Synonyms SCAMP-4
Description secretory carrier membrane protein 4
Transcript NM_079834   
Expression
Putative miRNA Targets on SCAMP4
3'UTR of SCAMP4
(miRNA target sites are highlighted)		 
>SCAMP4|NM_079834|3'UTR
   1 AGGGAGCCTGCCCTGCCCCCACCGCCCACCACCTCCTCCCCTTCATTCCTGCTGCTACCCCTGGTCCCGAGGGCTGGGAG
  81 TACCTGGGGCCCCATCCCCCCAGCTGGGATGGTGGAAGCCGGTGGTGGCCACGGACCGCCCCCCTCCTGCCAGGGCCACA
 161 GAACCCGTGTTCATCTCATCCGAGAGCGGAGTTCCTCACAAGCACTCCCCAGCAGCCCTTGGCCTCTGCCGTCCACAGGA
 241 CGCCCTCTTGCTCCCGGAAACGTGTGGTCACCCGCCGTCCACTGCACGGCTGGTACGGCCTTGTCTTCAGGTCTCGAGGC
 321 CTGACTCCGGGGGACAGGTGGCAGCAGGTCGGCCGCCCTCCCGTCCTCCCAGAGCTGCTGGCGCTGAGGTCAGAGCGGGT
 401 CTGATGGGGAGCTCCGTCTCACCGGCCACCCGCCGTCACCATGGCAGATGCCCTTGGCCGGAACTAATAAGAGGCGTCGG
 481 GGCCAGCTTCCGGTCCCCTGCAGTGATAGAGGGCTTGGTGCCTAGCTGAGTCCTCGCTGTCCCCGCCATCCCCTGATCTG
 561 TGCGGCTCCAGCCTCGCCCCCTCCCCACGTGCACCATACCTGGGGAGTTCCTGGTCCAGGGTATCCTGGGGCCACCCTCC
 641 CTGCCTCCAAAACAGGGATCCCTGGCAGGCTGTCTTTCCACGCCCCTGAGTTCAGAGTCGGGGACCCAGGCCAGGTCGGG
 721 AGCACAGCCGCTCCCCAAACCCAGCAAACCGGCAGAGAGCCGGTTTCCCAGCAGCCGGAGCCCTGCAGGAGAGGCCTTTG
 801 TGTTTTGTTTTGTTTTGTTTTTTCTCTTTTGAGACAAGAGTTTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATC
 881 TCGGCTCACTGCAACCTCTGCCTCCCGTGTTCAAGCAGTTCTCCTGCCTCAGCCTCCCAAATAGCTGGGATTACAGTTGC
 961 CTGCCACCACGCCCAGCTAATTTTTATATTTTTAGTACAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCC
1041 TGACCTCAAGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATAATAGGTGTCAGCCACCGCGCCCAGCCTGGAGTG
1121 GCCTTTTATGAGAGGGGACCCGTCAAATCTGTGCCTTATGGAGGGGTCCGGCAGCGGCCACAATTGTCTTGTCCCCTCAC
1201 CCCCCAACTCCCCCTGGAACACCTCTCCCAGGCAAGACATTTTCACAGCACCATTCACAACGGTTGGGCCAAAAAGAAAC
1281 TTTTCCTTCATCATTTCCTGCACTCGCTGACCACAACTTTGGACACCCCAGGCTGCCACCCCTCCCCACCCGTTCACCCC
1361 CAGGATGCTGTTGCTGTAGGACGCCTGCTGCCCTGGAGCCCTCCCCAGGATGTGAGCCAGTCCCCTCGCTGGTACGGAAT
1441 GCCGCTGGGTGCCCGGAGGCGGCCATGGTGTCTCGATGGACGGCAGCCAGGATGGAGCACCCATGGGTCTCACGGCCATG
1521 CTTCAGGGTCTTCAGGTCCTGCCCCCGGCCAGTCTGCCAAGAGGCACCCCCTTCCCCAGCCTCTCGCCTGCACTGATGCA
1601 GACAAAATCTCACCTGGCAGGCCCAACCCCCCCCCACCCCTCCCCCGCCGTGTGTGGCCCCTCGCCGCATCGTTGGGGTT
1681 TTGTTATGTGAAAATATCCTGGAAATAAATACATGTTTCTGCACTTAGAGCCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acucuguccAAGUACGACGAUa 5'
                   ||| |||||||| 
Target 5' tccccttcaTTCCTGCTGCTAc 3'
 37 - 58 157.00 -11.40
2 
miRNA  3' acucuGUCCAAGUACGACGAUa 5'
               |||| |  ||:||||: 
Target 5' accccCAGGATGCTGTTGCTGt 3'
 1356 - 1377 129.00 -14.70
3 
miRNA  3' acucuguccaaguaCGACGAUa 5'
                        ||||||: 
Target 5' cccgtcctcccagaGCTGCTGg 3'
 360 - 381 124.00 -9.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26993825 16 COSMIC
COSN13789891 24 COSMIC
COSN14824360 32 COSMIC
COSN30165600 36 COSMIC
COSN20047693 69 COSMIC
COSN31596005 171 COSMIC
COSN31555291 252 COSMIC
COSN28656297 371 COSMIC
COSN26162627 460 COSMIC
COSN25042340 559 COSMIC
COSN27802292 681 COSMIC
COSN9350197 775 COSMIC
COSN20115289 838 COSMIC
COSM7230644 1107 COSMIC
COSM6003790 1120 COSMIC
COSM8654125 1226 COSMIC
COSM3100868 1262 COSMIC
COSM8639032 1290 COSMIC
COSM6003447 1384 COSMIC
COSM8887156 1445 COSMIC
COSM8657704 1475 COSMIC
COSM6280829 1496 COSMIC
COSM7710918 1512 COSMIC
COSM9850419 1626 COSMIC
COSM9849268 1627 COSMIC
COSM9849624 1628 COSMIC
COSM1172602 1636 COSMIC
COSM9849661 1636 COSMIC
COSM5034170 1642 COSMIC
COSM3766305 1660 COSMIC
COSM5031927 1673 COSMIC
COSN31595999 1714 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs984432087 4 dbSNP
rs375942866 7 dbSNP
rs759102301 8 dbSNP
rs1468310240 9 dbSNP
rs748324244 9 dbSNP
rs1344186014 11 dbSNP
rs1417454265 12 dbSNP
rs1315228104 13 dbSNP
rs756595850 14 dbSNP
rs1356500509 15 dbSNP
rs767045975 17 dbSNP
rs1282880453 18 dbSNP
rs752295255 19 dbSNP
rs760315022 24 dbSNP
rs370175173 25 dbSNP
rs753646131 28 dbSNP
rs1213248636 29 dbSNP
rs1202630076 30 dbSNP
rs922887096 35 dbSNP
rs779042714 40 dbSNP
rs1269448361 42 dbSNP
rs1338363042 44 dbSNP
rs1235601757 45 dbSNP
rs1470890291 46 dbSNP
rs1177321638 49 dbSNP
rs1233334950 52 dbSNP
rs1469479723 58 dbSNP
rs934132794 59 dbSNP
rs1305441501 60 dbSNP
rs565149784 61 dbSNP
rs981312834 62 dbSNP
rs985662043 64 dbSNP
rs1380274437 65 dbSNP
rs1336388447 66 dbSNP
rs1450716282 69 dbSNP
rs911275303 70 dbSNP
rs769305904 72 dbSNP
rs868179027 73 dbSNP
rs569277285 74 dbSNP
rs972504872 76 dbSNP
rs902514257 78 dbSNP
rs1425401099 79 dbSNP
rs1385632879 85 dbSNP
rs1394591014 85 dbSNP
rs1442371643 88 dbSNP
rs140344969 89 dbSNP
rs1485221833 90 dbSNP
rs935374418 90 dbSNP
rs1056293209 93 dbSNP
rs896432133 94 dbSNP
rs112133628 96 dbSNP
rs943383361 101 dbSNP
rs1012463640 102 dbSNP
rs559960018 116 dbSNP
rs887485266 117 dbSNP
rs1382869872 119 dbSNP
rs1287116431 121 dbSNP
rs756570691 122 dbSNP
rs1014713523 124 dbSNP
rs1442505663 126 dbSNP
rs139387023 133 dbSNP
rs867651590 134 dbSNP
rs1022743395 138 dbSNP
rs1030300435 139 dbSNP
rs1193465266 139 dbSNP
rs1215787701 140 dbSNP
rs1291625606 141 dbSNP
rs573756259 143 dbSNP
rs1344672485 144 dbSNP
rs372413412 145 dbSNP
rs747808576 148 dbSNP
rs1254666844 154 dbSNP
rs946909789 157 dbSNP
rs557542798 168 dbSNP
rs1422528072 175 dbSNP
rs919734005 179 dbSNP
rs1168206133 182 dbSNP
rs187733041 183 dbSNP
rs527412304 188 dbSNP
rs192726780 189 dbSNP
rs552223482 190 dbSNP
rs1420920860 199 dbSNP
rs766699917 200 dbSNP
rs1268799669 201 dbSNP
rs1197816085 203 dbSNP
rs1484281554 207 dbSNP
rs1251655443 211 dbSNP
rs910674321 215 dbSNP
rs981052113 215 dbSNP
rs1257941844 217 dbSNP
rs749082224 219 dbSNP
rs1169080129 222 dbSNP
rs923283117 231 dbSNP
rs947999726 232 dbSNP
rs1053397483 241 dbSNP
rs770794299 242 dbSNP
rs112436547 243 dbSNP
rs540131431 244 dbSNP
rs1173895801 248 dbSNP
rs1006095259 256 dbSNP
rs555412908 257 dbSNP
rs897605399 262 dbSNP
rs570359517 263 dbSNP
rs1002590017 264 dbSNP
rs531299009 265 dbSNP
rs1030003406 266 dbSNP
rs1258548606 268 dbSNP
rs1204532867 274 dbSNP
rs549844355 275 dbSNP
rs1007136919 276 dbSNP
rs759505369 277 dbSNP
rs371832691 278 dbSNP
rs979600305 279 dbSNP
rs1280025388 282 dbSNP
rs1238065727 284 dbSNP
rs113331616 287 dbSNP
rs1338359762 288 dbSNP
rs1026936452 289 dbSNP
rs1242780817 293 dbSNP
rs1334150484 294 dbSNP
rs1477512929 295 dbSNP
rs956803805 297 dbSNP
rs992528630 298 dbSNP
rs1468978235 301 dbSNP
rs1370559779 303 dbSNP
rs1192152328 309 dbSNP
rs1420618923 310 dbSNP
rs917931601 315 dbSNP
rs948084206 316 dbSNP
rs985273068 317 dbSNP
rs911067827 320 dbSNP
rs1044983856 322 dbSNP
rs964763657 327 dbSNP
rs909143010 329 dbSNP
rs941828772 330 dbSNP
rs934677551 332 dbSNP
rs1036216393 333 dbSNP
rs568009072 334 dbSNP
rs1397566162 336 dbSNP
rs997276661 343 dbSNP
rs1044540734 346 dbSNP
rs906059599 347 dbSNP
rs1295098489 351 dbSNP
rs764101660 352 dbSNP
rs1232516630 354 dbSNP
rs1263470325 355 dbSNP
rs888784926 356 dbSNP
rs1293809043 358 dbSNP
rs1207150130 363 dbSNP
rs1007661894 364 dbSNP
rs1289222839 367 dbSNP
rs1488030519 370 dbSNP
rs3810415 371 dbSNP
rs1362092333 374 dbSNP
rs1027067893 383 dbSNP
rs553536276 384 dbSNP
rs114349190 389 dbSNP
rs761981333 396 dbSNP
rs1304210286 397 dbSNP
rs1000964022 398 dbSNP
rs765488386 399 dbSNP
rs1172887798 400 dbSNP
rs542864652 401 dbSNP
rs992247562 402 dbSNP
rs918031931 407 dbSNP
rs1481422460 411 dbSNP
rs879381615 414 dbSNP
rs373906254 416 dbSNP
rs981207353 417 dbSNP
rs909098407 419 dbSNP
rs1375462607 424 dbSNP
rs941930481 425 dbSNP
rs1307737814 427 dbSNP
rs902430851 429 dbSNP
rs750841489 432 dbSNP
rs577177963 433 dbSNP
rs933182282 435 dbSNP
rs544590987 436 dbSNP
rs888893088 443 dbSNP
rs1344064916 445 dbSNP
rs1238128912 451 dbSNP
rs376951273 454 dbSNP
rs947638840 459 dbSNP
rs1043135655 460 dbSNP
rs143312528 461 dbSNP
rs1001080241 462 dbSNP
rs1254662522 468 dbSNP
rs1056804171 473 dbSNP
rs896870180 474 dbSNP
rs752085827 475 dbSNP
rs1031248005 476 dbSNP
rs892633030 477 dbSNP
rs1437450710 479 dbSNP
rs755491217 480 dbSNP
rs1462316372 483 dbSNP
rs1263180159 489 dbSNP
rs542505573 492 dbSNP
rs969889370 493 dbSNP
rs1301065569 498 dbSNP
rs560688391 499 dbSNP
rs1373041526 510 dbSNP
rs998059698 513 dbSNP
rs1454753719 514 dbSNP
rs1016282147 517 dbSNP
rs1406990554 518 dbSNP
rs562576050 528 dbSNP
rs1391821044 531 dbSNP
rs527837243 536 dbSNP
rs150470049 537 dbSNP
rs933155375 539 dbSNP
rs1406969673 542 dbSNP
rs1176435708 545 dbSNP
rs564201439 546 dbSNP
rs910280060 551 dbSNP
rs138152619 556 dbSNP
rs1202491389 559 dbSNP
rs549346853 561 dbSNP
rs1254831175 563 dbSNP
rs568050831 564 dbSNP
rs183804350 565 dbSNP
rs918765092 567 dbSNP
rs1377049267 569 dbSNP
rs1248563389 570 dbSNP
rs999467154 576 dbSNP
rs1052616334 577 dbSNP
rs1314546362 578 dbSNP
rs550830129 582 dbSNP
rs565541747 587 dbSNP
rs1290625909 588 dbSNP
rs1025580386 589 dbSNP
rs539579957 590 dbSNP
rs1002691910 592 dbSNP
rs1426247640 594 dbSNP
rs1173334627 597 dbSNP
rs1016397082 608 dbSNP
rs901051915 613 dbSNP
rs1263183169 617 dbSNP
rs1187667605 620 dbSNP
rs1485841331 621 dbSNP
rs1374778130 622 dbSNP
rs1462441871 627 dbSNP
rs1360542593 628 dbSNP
rs149553529 629 dbSNP
rs1169787241 630 dbSNP
rs1309372845 632 dbSNP
rs998112027 636 dbSNP
rs972090060 637 dbSNP
rs1381666148 644 dbSNP
rs1361194137 648 dbSNP
rs1296209034 654 dbSNP
rs1026209968 656 dbSNP
rs1365961910 662 dbSNP
rs1328223898 663 dbSNP
rs774237951 670 dbSNP
rs1456043571 675 dbSNP
rs954808032 680 dbSNP
rs144296257 682 dbSNP
rs372033551 683 dbSNP
rs964607061 686 dbSNP
rs1328207544 687 dbSNP
rs978477219 689 dbSNP
rs1257922732 691 dbSNP
rs1208333132 692 dbSNP
rs138853632 694 dbSNP
rs1252066351 695 dbSNP
rs1034319403 696 dbSNP
rs934314707 700 dbSNP
rs746788814 701 dbSNP
rs1225239080 707 dbSNP
rs1487945146 710 dbSNP
rs914133217 712 dbSNP
rs1345967091 716 dbSNP
rs949670539 718 dbSNP
rs770753996 719 dbSNP
rs993060605 722 dbSNP
rs377463616 726 dbSNP
rs918746628 726 dbSNP
rs116454078 730 dbSNP
rs557731090 731 dbSNP
rs761935793 748 dbSNP
rs1037779354 751 dbSNP
rs899264098 752 dbSNP
rs765169080 756 dbSNP
rs1197234848 758 dbSNP
rs1026322679 762 dbSNP
rs562652586 763 dbSNP
rs1195442860 765 dbSNP
rs1456536783 769 dbSNP
rs1009220901 778 dbSNP
rs1204330908 781 dbSNP
rs1017558869 783 dbSNP
rs1457600301 787 dbSNP
rs141781512 792 dbSNP
rs1230808487 794 dbSNP
rs978593656 795 dbSNP
rs1400665158 796 dbSNP
rs925675891 799 dbSNP
rs1278164727 801 dbSNP
rs1405995142 801 dbSNP
rs1469829016 801 dbSNP
rs955807366 806 dbSNP
rs988396361 809 dbSNP
rs916894917 812 dbSNP
rs1364712043 825 dbSNP
rs1235589382 827 dbSNP
rs201009543 832 dbSNP
rs949787087 832 dbSNP
rs11347146 836 dbSNP
rs398033695 836 dbSNP
rs200645711 838 dbSNP
rs1047068902 839 dbSNP
rs1277899552 841 dbSNP
rs1218964254 843 dbSNP
rs1352623773 845 dbSNP
rs1262103635 847 dbSNP
rs904570218 849 dbSNP
rs1374233369 851 dbSNP
rs111394244 853 dbSNP
rs546377631 854 dbSNP
rs1034291435 857 dbSNP
rs1261017389 859 dbSNP
rs960055350 862 dbSNP
rs1188484932 867 dbSNP
rs1014449102 870 dbSNP
rs1386251572 872 dbSNP
rs568688821 877 dbSNP
rs899210429 881 dbSNP
rs993591428 883 dbSNP
rs751893345 884 dbSNP
rs951576549 886 dbSNP
rs112257334 891 dbSNP
rs984657277 892 dbSNP
rs1262287728 896 dbSNP
rs1215630358 897 dbSNP
rs762581155 898 dbSNP
rs1246222820 900 dbSNP
rs576074220 901 dbSNP
rs187520533 903 dbSNP
rs1281949950 904 dbSNP
rs1297640298 907 dbSNP
rs1327535587 908 dbSNP
rs1298064194 912 dbSNP
rs1398604099 918 dbSNP
rs1367841188 919 dbSNP
rs146240004 923 dbSNP
rs528813362 924 dbSNP
rs1017922253 925 dbSNP
rs547298937 928 dbSNP
rs1411830680 931 dbSNP
rs879417744 940 dbSNP
rs1358635228 944 dbSNP
rs760031960 950 dbSNP
rs1192852132 951 dbSNP
rs1487211072 955 dbSNP
rs1303894147 956 dbSNP
rs975182526 959 dbSNP
rs1450715800 963 dbSNP
rs796418184 970 dbSNP
rs559588978 971 dbSNP
rs533008151 972 dbSNP
rs79919621 975 dbSNP
rs80112196 976 dbSNP
rs77210929 977 dbSNP
rs971458090 987 dbSNP
rs979807905 996 dbSNP
rs946660532 997 dbSNP
rs926846501 1001 dbSNP
rs1043919540 1002 dbSNP
rs1348359877 1003 dbSNP
rs1001557550 1004 dbSNP
rs1486345400 1007 dbSNP
rs1211539591 1015 dbSNP
rs1422973951 1021 dbSNP
rs1169944183 1024 dbSNP
rs768055912 1034 dbSNP
rs1055837589 1035 dbSNP
rs1477541373 1045 dbSNP
rs551537925 1049 dbSNP
rs895815878 1050 dbSNP
rs1014248241 1051 dbSNP
rs1437944286 1059 dbSNP
rs1482174938 1061 dbSNP
rs370626550 1062 dbSNP
rs887325617 1068 dbSNP
rs1410511879 1069 dbSNP
rs1005817169 1071 dbSNP
rs920751848 1076 dbSNP
rs538362934 1085 dbSNP
rs1017500695 1087 dbSNP
rs550250688 1088 dbSNP
rs1436603128 1089 dbSNP
rs1335499422 1092 dbSNP
rs1408228709 1093 dbSNP
rs929497710 1094 dbSNP
rs1048255921 1101 dbSNP
rs1439944028 1104 dbSNP
rs890571307 1104 dbSNP
rs568472083 1105 dbSNP
rs1039052668 1106 dbSNP
rs6510629 1107 dbSNP
rs1310864268 1112 dbSNP
rs554555068 1113 dbSNP
rs913580237 1115 dbSNP
rs1224646649 1118 dbSNP
rs1445621207 1130 dbSNP
rs1307283335 1138 dbSNP
rs1000075930 1142 dbSNP
rs755337655 1143 dbSNP
rs1465463277 1148 dbSNP
rs1161055424 1150 dbSNP
rs1219273192 1150 dbSNP
rs1277912073 1154 dbSNP
rs1379316120 1159 dbSNP
rs1156443293 1160 dbSNP
rs926445959 1162 dbSNP
rs937881455 1166 dbSNP
rs572680108 1170 dbSNP
rs950173374 1171 dbSNP
rs1217830882 1174 dbSNP
rs1238562563 1175 dbSNP
rs777380188 1176 dbSNP
rs200424152 1177 dbSNP
rs1248411732 1179 dbSNP
rs1178279283 1184 dbSNP
rs887135984 1185 dbSNP
rs1236551019 1191 dbSNP
rs750975025 1192 dbSNP
rs1455690695 1199 dbSNP
rs1290500759 1201 dbSNP
rs1173225751 1203 dbSNP
rs201245035 1204 dbSNP
rs868422572 1205 dbSNP
rs1413272186 1208 dbSNP
rs1296003106 1209 dbSNP
rs1368645279 1211 dbSNP
rs1173115351 1213 dbSNP
rs1017229704 1215 dbSNP
rs1421483666 1215 dbSNP
rs1465415005 1221 dbSNP
rs1488193164 1222 dbSNP
rs1261455638 1224 dbSNP
rs1225119342 1228 dbSNP
rs971192435 1237 dbSNP
rs1265011298 1240 dbSNP
rs1372718409 1247 dbSNP
rs980138020 1249 dbSNP
rs879909822 1252 dbSNP
rs558348123 1253 dbSNP
rs1029844391 1254 dbSNP
rs1219130529 1259 dbSNP
rs1339702782 1261 dbSNP
rs576533267 1262 dbSNP
rs1216284052 1263 dbSNP
rs962405986 1264 dbSNP
rs753565511 1265 dbSNP
rs1317118689 1275 dbSNP
rs1292573712 1281 dbSNP
rs1455995288 1285 dbSNP
rs987925751 1287 dbSNP
rs1196526625 1288 dbSNP
rs1172080624 1289 dbSNP
rs973647164 1294 dbSNP
rs920868550 1304 dbSNP
rs967768989 1306 dbSNP
rs543117836 1307 dbSNP
rs761078123 1308 dbSNP
rs1208282295 1309 dbSNP
rs1481681194 1312 dbSNP
rs1258767001 1317 dbSNP
rs1198048374 1318 dbSNP
rs1199774205 1325 dbSNP
rs983649340 1330 dbSNP
rs112567033 1338 dbSNP
rs979750978 1340 dbSNP
rs1331473227 1341 dbSNP
rs911940792 1345 dbSNP
rs1477053823 1349 dbSNP
rs926581707 1351 dbSNP
rs937935552 1352 dbSNP
rs561406477 1353 dbSNP
rs1465493445 1357 dbSNP
rs1039412036 1359 dbSNP
rs1398749763 1363 dbSNP
rs900501910 1376 dbSNP
rs936028723 1377 dbSNP
rs887098250 1379 dbSNP
rs1054288663 1383 dbSNP
rs573342101 1384 dbSNP
rs1322416009 1388 dbSNP
rs1347632097 1394 dbSNP
rs1456489695 1395 dbSNP
rs941407311 1396 dbSNP
rs531317348 1401 dbSNP
rs1202081143 1406 dbSNP
rs1345516502 1407 dbSNP
rs766246396 1408 dbSNP
rs202011581 1410 dbSNP
rs1278844200 1413 dbSNP
rs559421419 1417 dbSNP
rs879197009 1423 dbSNP
rs139460230 1425 dbSNP
rs1355409867 1426 dbSNP
rs551357523 1428 dbSNP
rs1024147298 1429 dbSNP
rs1336763005 1430 dbSNP
rs550717860 1431 dbSNP
rs569296164 1436 dbSNP
rs563499862 1437 dbSNP
rs1158270712 1439 dbSNP
rs530681534 1441 dbSNP
rs968116148 1444 dbSNP
rs77352181 1445 dbSNP
rs1033316510 1452 dbSNP
rs1218881612 1453 dbSNP
rs1442969574 1455 dbSNP
rs113233543 1456 dbSNP
rs745654152 1461 dbSNP
rs1027877801 1462 dbSNP
rs950962679 1464 dbSNP
rs1370591865 1467 dbSNP
rs983986066 1470 dbSNP
rs771956622 1475 dbSNP
rs780050298 1476 dbSNP
rs1341917342 1478 dbSNP
rs1402318631 1480 dbSNP
rs1402000601 1482 dbSNP
rs974837951 1483 dbSNP
rs950612971 1487 dbSNP
rs983267197 1491 dbSNP
rs1387274053 1493 dbSNP
rs1163911904 1495 dbSNP
rs922050404 1503 dbSNP
rs1367874803 1508 dbSNP
rs1185320710 1512 dbSNP
rs908583032 1512 dbSNP
rs935974903 1514 dbSNP
rs535882635 1515 dbSNP
rs1291511398 1517 dbSNP
rs1209977095 1524 dbSNP
rs1355031337 1525 dbSNP
rs1282985488 1527 dbSNP
rs1220983103 1533 dbSNP
rs1278000980 1542 dbSNP
rs1398109838 1542 dbSNP
rs1398469243 1546 dbSNP
rs1054404550 1547 dbSNP
rs913114224 1548 dbSNP
rs932870904 1552 dbSNP
rs1162764939 1553 dbSNP
rs1051374253 1555 dbSNP
rs1478775149 1556 dbSNP
rs1192670254 1562 dbSNP
rs1476711522 1568 dbSNP
rs1243757874 1573 dbSNP
rs945995044 1575 dbSNP
rs1046096519 1576 dbSNP
rs1242510226 1577 dbSNP
rs758708195 1581 dbSNP
rs144152763 1582 dbSNP
rs1055538201 1586 dbSNP
rs565902969 1587 dbSNP
rs1258840527 1589 dbSNP
rs1443393050 1590 dbSNP
rs1217244788 1604 dbSNP
rs898259219 1606 dbSNP
rs1370172174 1612 dbSNP
rs1275702504 1615 dbSNP
rs1187269908 1618 dbSNP
rs779265611 1621 dbSNP
rs1236033499 1622 dbSNP
rs995144687 1624 dbSNP
rs1441169092 1625 dbSNP
rs759288513 1625 dbSNP
rs773534673 1625 dbSNP
rs1158840839 1626 dbSNP
rs1169868906 1627 dbSNP
rs1401016648 1627 dbSNP
rs1426982463 1627 dbSNP
rs71174396 1627 dbSNP
rs752572159 1627 dbSNP
rs759022863 1627 dbSNP
rs766863957 1627 dbSNP
rs74929181 1628 dbSNP
rs1000586513 1630 dbSNP
rs1417296768 1630 dbSNP
rs1477512552 1632 dbSNP
rs60844215 1632 dbSNP
rs1402820755 1633 dbSNP
rs145088809 1633 dbSNP
rs1395298090 1636 dbSNP
rs1012386460 1637 dbSNP
rs1337240223 1639 dbSNP
rs1449320475 1641 dbSNP
rs1023384863 1642 dbSNP
rs1025317155 1644 dbSNP
rs1061826 1645 dbSNP
rs1238011726 1646 dbSNP
rs1376211806 1647 dbSNP
rs1005126376 1648 dbSNP
rs1019653247 1649 dbSNP
rs966225361 1650 dbSNP
rs192055415 1651 dbSNP
rs1254554080 1652 dbSNP
rs1392939636 1653 dbSNP
rs184818852 1654 dbSNP
rs1178919658 1659 dbSNP
rs537238852 1659 dbSNP
rs8730 1660 dbSNP
rs1237158737 1663 dbSNP
rs1437353499 1664 dbSNP
rs1174921418 1665 dbSNP
rs1484543468 1666 dbSNP
rs533769530 1667 dbSNP
rs950693035 1669 dbSNP
rs990078133 1670 dbSNP
rs913228782 1673 dbSNP
rs1288475637 1679 dbSNP
rs1170698265 1684 dbSNP
rs1061828 1688 dbSNP
rs1353198046 1689 dbSNP
rs540690590 1690 dbSNP
rs1230036385 1692 dbSNP
rs1045631037 1693 dbSNP
rs1303349022 1696 dbSNP
rs928570321 1713 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acucuguccAAGUACGACGAUa 5'
                   ||| |||||||| 
Target 5' ---ccuucaUUCCUGCUGCUAc 3'
 		1 - 19
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177605. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_7 PAR-CLIP data was present in ERX177621. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_11 PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000316097.8 | 3UTR | CCUUCAUUCCUGCUGCUACCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
180 hsa-miR-4524a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055251 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT055826 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT060573 CCND1 cyclin D1 2 2
MIRT061013 C1ORF21 chromosome 1 open reading frame 21 2 6
MIRT064694 CCND2 cyclin D2 2 4
MIRT075268 SNTB2 syntrophin beta 2 2 4
MIRT079668 NAPG NSF attachment protein gamma 2 12
MIRT081651 CCNE1 cyclin E1 2 4
MIRT082996 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT083463 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 4
MIRT085755 RIF1 replication timing regulatory factor 1 2 2
MIRT086022 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT087431 ZNRF3 zinc and ring finger 3 2 2
MIRT088786 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT089221 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT093696 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 6
MIRT095090 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT096249 CANX calnexin 2 2
MIRT100215 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT100746 VEGFA vascular endothelial growth factor A 2 12
MIRT100904 CD2AP CD2 associated protein 2 2
MIRT102647 UBN2 ubinuclein 2 2 10
MIRT103882 FOXK1 forkhead box K1 2 2
MIRT104246 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT106310 ZFHX4 zinc finger homeobox 4 2 6
MIRT107696 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT114943 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT117671 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT133799 SKI SKI proto-oncogene 2 2
MIRT140167 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT142279 DCTN5 dynactin subunit 5 2 8
MIRT143288 N4BP1 NEDD4 binding protein 1 2 2
MIRT165939 CREBRF CREB3 regulatory factor 2 2
MIRT175251 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT186381 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT191470 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT196480 TAOK1 TAO kinase 1 2 2
MIRT201470 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT204615 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204646 MOB4 MOB family member 4, phocein 2 8
MIRT204749 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT206031 NUP50 nucleoporin 50 2 6
MIRT211196 FGF2 fibroblast growth factor 2 2 4
MIRT229353 ZNF449 zinc finger protein 449 2 2
MIRT247138 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT249461 ZNF691 zinc finger protein 691 2 4
MIRT256314 CDC42SE2 CDC42 small effector 2 2 2
MIRT258419 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT265083 CHEK1 checkpoint kinase 1 2 2
MIRT270561 SETD1B SET domain containing 1B 2 2
MIRT274749 RAB3IP RAB3A interacting protein 2 2
MIRT277515 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 4
MIRT289642 CBX2 chromobox 2 2 2
MIRT301001 MTMR3 myotubularin related protein 3 2 2
MIRT307149 CTDSPL CTD small phosphatase like 2 4
MIRT309021 USP53 ubiquitin specific peptidase 53 2 2
MIRT314100 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 8
MIRT319338 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT320619 ZNRF2 zinc and ring finger 2 2 2
MIRT324285 LURAP1L leucine rich adaptor protein 1 like 2 2
MIRT446498 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT448437 TLL1 tolloid like 1 2 2
MIRT461537 ACTR3B ARP3 actin related protein 3 homolog B 2 2
MIRT463162 ZNF367 zinc finger protein 367 2 10
MIRT463493 ZC3H10 zinc finger CCCH-type containing 10 2 2
MIRT465154 TSC22D2 TSC22 domain family member 2 2 2
MIRT466418 TFAP2A transcription factor AP-2 alpha 2 8
MIRT468278 SFT2D2 SFT2 domain containing 2 2 2
MIRT469399 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT471941 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT473688 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT479618 CDC25A cell division cycle 25A 2 2
MIRT482098 AKT3 AKT serine/threonine kinase 3 2 4
MIRT483995 ATAD5 ATPase family, AAA domain containing 5 2 12
MIRT485205 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT498763 C3orf38 chromosome 3 open reading frame 38 2 8
MIRT498961 ORC4 origin recognition complex subunit 4 2 8
MIRT499440 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT500080 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 8
MIRT500305 ZNF622 zinc finger protein 622 2 8
MIRT500410 ZMAT3 zinc finger matrin-type 3 2 8
MIRT500789 TLK1 tousled like kinase 1 2 6
MIRT500930 SRPR SRP receptor alpha subunit 2 6
MIRT500943 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 8
MIRT501068 SMAD7 SMAD family member 7 2 8
MIRT501711 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT502627 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT502910 CDCA4 cell division cycle associated 4 2 8
MIRT502935 CDC37L1 cell division cycle 37 like 1 2 8
MIRT504531 ZNF620 zinc finger protein 620 2 6
MIRT505106 YTHDC1 YTH domain containing 1 2 6
MIRT505337 TMEM245 transmembrane protein 245 2 6
MIRT505383 TMEM100 transmembrane protein 100 2 2
MIRT505678 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT506157 PLAG1 PLAG1 zinc finger 2 8
MIRT506183 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 6
MIRT506475 MYO5A myosin VA 2 6
MIRT506826 KIF23 kinesin family member 23 2 6
MIRT507160 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT507511 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT507845 CCNE2 cyclin E2 2 6
MIRT510403 ZNF507 zinc finger protein 507 2 2
MIRT518078 TRIM35 tripartite motif containing 35 2 2
MIRT518982 NNT nicotinamide nucleotide transhydrogenase 2 4
MIRT521045 SLC2A3 solute carrier family 2 member 3 2 4
MIRT521190 SBNO1 strawberry notch homolog 1 2 6
MIRT522088 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT524846 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT527787 TMEM44 transmembrane protein 44 2 4
MIRT537803 EFNB2 ephrin B2 2 4
MIRT540830 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541140 PISD phosphatidylserine decarboxylase 2 2
MIRT541419 CBX4 chromobox 4 2 2
MIRT543517 PRSS21 protease, serine 21 2 2
MIRT543824 GSG1 germ cell associated 1 2 2
MIRT544959 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT545179 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 4
MIRT545335 CCDC83 coiled-coil domain containing 83 2 2
MIRT545518 RSL24D1 ribosomal L24 domain containing 1 2 2
MIRT545670 DECR1 2,4-dienoyl-CoA reductase 1 2 2
MIRT545931 ZBTB44 zinc finger and BTB domain containing 44 2 4
MIRT546102 USP48 ubiquitin specific peptidase 48 2 4
MIRT546598 SALL1 spalt like transcription factor 1 2 4
MIRT546626 RTN4 reticulon 4 2 2
MIRT547651 KPNA3 karyopherin subunit alpha 3 2 2
MIRT547987 HCFC2 host cell factor C2 2 4
MIRT548717 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT548931 CDK17 cyclin dependent kinase 17 2 2
MIRT549067 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT549266 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT550460 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT550806 FAM229B family with sequence similarity 229 member B 2 2
MIRT552024 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552334 ZNF704 zinc finger protein 704 2 2
MIRT552732 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT553795 SZRD1 SUZ RNA binding domain containing 1 2 4
MIRT554694 RNF149 ring finger protein 149 2 2
MIRT555133 PTPRD protein tyrosine phosphatase, receptor type D 2 2
MIRT555264 PRDM4 PR/SET domain 4 2 2
MIRT556848 KANK1 KN motif and ankyrin repeat domains 1 2 4
MIRT557474 GPR27 G protein-coupled receptor 27 2 4
MIRT558018 EXT1 exostosin glycosyltransferase 1 2 2
MIRT558498 CYP26B1 cytochrome P450 family 26 subfamily B member 1 2 4
MIRT558579 CREBL2 cAMP responsive element binding protein like 2 2 4
MIRT558610 COX6B1 cytochrome c oxidase subunit 6B1 2 4
MIRT558650 CNKSR3 CNKSR family member 3 2 2
MIRT558986 CA8 carbonic anhydrase 8 2 2
MIRT559141 BTN3A3 butyrophilin subfamily 3 member A3 2 2
MIRT559327 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT562021 LANCL1 LanC like 1 2 2
MIRT562869 KIAA1456 KIAA1456 2 2
MIRT563074 SLC25A12 solute carrier family 25 member 12 2 2
MIRT563496 DLGAP3 DLG associated protein 3 2 2
MIRT563890 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT564311 CCNT1 cyclin T1 2 2
MIRT564942 XKR7 XK related 7 2 2
MIRT564979 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT565423 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566824 MAP3K7 mitogen-activated protein kinase kinase kinase 7 2 2
MIRT571961 KIF5B kinesin family member 5B 2 2
MIRT575877 Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2 3
MIRT576523 Txlna taxilin alpha 2 2
MIRT614693 TRAK1 trafficking kinesin protein 1 2 2
MIRT616065 ZC3H14 zinc finger CCCH-type containing 14 2 2
MIRT618838 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT624626 ATXN2 ataxin 2 2 2
MIRT624652 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT640314 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT659248 CUL3 cullin 3 2 2
MIRT680972 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682261 RS1 retinoschisin 1 2 2
MIRT682505 GLP2R glucagon like peptide 2 receptor 2 2
MIRT693904 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT699214 SLCO3A1 solute carrier organic anion transporter family member 3A1 2 2
MIRT699373 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699451 SLC16A9 solute carrier family 16 member 9 2 2
MIRT701230 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT702849 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT706163 CASK calcium/calmodulin dependent serine protein kinase 2 3
MIRT718990 UTP15 UTP15, small subunit processome component 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4524a-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4524a-5p Cetuximab resistant tissue (colorectal carcinoma)

Error report submission