miRTarBase - #MIRT118184


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pre-miRNA Information
pre-miRNA hsa-mir-3921   
Genomic Coordinates chr3: 99964314 - 99964398
Description Homo sapiens miR-3921 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3921
Sequence 52| UCUCUGAGUACCAUAUGCCUUGU |74
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN7769671 6 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs758695096 5 dbSNP
rs539077798 6 dbSNP
rs954620527 10 dbSNP
rs1437951547 17 dbSNP
Putative Targets

Gene Information
Gene Symbol ZNF544   
Synonyms -
Description zinc finger protein 544
Transcript NM_014480   
Expression
Putative miRNA Targets on ZNF544
3'UTR of ZNF544
(miRNA target sites are highlighted)		 
>ZNF544|NM_014480|3'UTR
   1 GAGTGCAGTCATTGTGGGAAAGCTTTCATCCAGAGGTCTCCCCTCATCATGCACCAGAGGACGCATGTCGGTGGGAAGAG
  81 CTATCAGTGTGACGTGTATTAAGCCAGCGGTTGTGACTCATTGAACATCAGAGGACATATCCTGGAGAAAAGCCCTACGA
 161 ATGCATTGATTGTGGGAAAGCCTTCAATGATCGCTCAACCCTTAGTAAACACGAGAGGACACACACTGGAGGCAAACCCT
 241 ATGAATGTGACCATTGCGAGAAAGCCTTTAGCCAACGGTGTCAACTTACTAGGCAGCAGAGAATTCATACTGGAGAGAAG
 321 CCCTGTGAATGTTAACAAATGTGGAAAAGCTTCCAGTTATGATACTTTCCTTATTCAACATGAGAAAGCTCATGGGCAAG
 401 AAACTCTATGAATAACCAAGATGGAGCCGGGTGCAGTTGCCAACACTTGTAATCCCAGCAGTTTGCGAGGCCGAGGCAGG
 481 TGGATCACTTGAGCCCAGGAGTTTGAAACCAGCCTGGGTAACATGGCAAAATCCTGTCTTTACAAAAAATACAAAAATTA
 561 GCCTAGCATGGTGGCGCATACCTGTAGTCCTAGCTACTCAGGAGGCTGAGGTGGGAGGATCACTTGAGCTTGGGAGGCGG
 641 TGGTTGCAGTGAGCTGTGATCATGCCATCACACCGCTGCCTTGTGAGAGATTGAGACACTCTAAATAAATAATAACCAAG
 721 ATGGGAAATTTCCCTGCCAGACCTTGTTTACTAGAAATCAGGTGGCCAAAACATGACTCTCAGAGTGGGGCTTCATGACC
 801 ATGTGCATCAGAATTGCCTGGAGTGTGCACTGAAACTGTGTATTACCAAGCTCACTCTAGCCAACTAAATAAAAATCTCT
 881 GGCAGTAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uguuCCG----UAUACCAUGAGUCUCu 5'
              |||    | |||   ||||||| 
Target 5' aggtGGCCAAAACATGACTCTCAGAGt 3'
 760 - 786 149.00 -12.80
2 
miRNA  3' uguUCCGUAUACCAUGAGU-CUCu 5'
             || | || | |||||| ||| 
Target 5' tgtAGTCCTA-GCTACTCAGGAGg 3'
 583 - 605 131.00 -10.00
3 
miRNA  3' uguuCCGUAUACCAUG-AGUCUCu 5'
              | |  || | || |||||| 
Target 5' ttgtGACTCATTGAACATCAGAGg 3'
 111 - 134 123.00 -10.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30165545 4 COSMIC
COSN13840478 6 COSMIC
COSN13840480 41 COSMIC
COSN30499262 47 COSMIC
COSN30171652 52 COSMIC
COSN30109151 59 COSMIC
COSN31500743 91 COSMIC
COSN20116172 106 COSMIC
COSN31559705 159 COSMIC
COSN30163202 169 COSMIC
COSN32057376 285 COSMIC
COSN31575339 288 COSMIC
COSN22827084 550 COSMIC
COSN16629753 590 COSMIC
COSN21368504 861 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs145551226 4 dbSNP
rs1462861186 5 dbSNP
rs1402875240 7 dbSNP
rs375604676 12 dbSNP
rs752628744 12 dbSNP
rs940382948 17 dbSNP
rs747545023 19 dbSNP
rs368354212 23 dbSNP
rs1210341880 25 dbSNP
rs762777697 25 dbSNP
rs1411009131 31 dbSNP
rs780839592 33 dbSNP
rs1417395015 36 dbSNP
rs372240144 37 dbSNP
rs866756512 38 dbSNP
rs373855300 39 dbSNP
rs1457000506 41 dbSNP
rs1298207940 44 dbSNP
rs985366980 44 dbSNP
rs1240995782 46 dbSNP
rs779766071 49 dbSNP
rs748755831 50 dbSNP
rs768312884 52 dbSNP
rs774043663 53 dbSNP
rs115838736 56 dbSNP
rs1027099546 63 dbSNP
rs943856034 64 dbSNP
rs1042617298 70 dbSNP
rs546668649 71 dbSNP
rs533306532 72 dbSNP
rs1392444545 74 dbSNP
rs1379607437 78 dbSNP
rs936452520 80 dbSNP
rs1490264924 81 dbSNP
rs11553359 82 dbSNP
rs1452192175 83 dbSNP
rs1200225526 86 dbSNP
rs532340789 87 dbSNP
rs1001739185 91 dbSNP
rs141246746 94 dbSNP
rs960328717 95 dbSNP
rs569027865 97 dbSNP
rs34204906 104 dbSNP
rs398101297 104 dbSNP
rs1020300899 109 dbSNP
rs894839513 110 dbSNP
rs538044323 112 dbSNP
rs1363313488 122 dbSNP
rs530752955 128 dbSNP
rs1423654807 134 dbSNP
rs1485279532 141 dbSNP
rs1260757451 154 dbSNP
rs7246802 155 dbSNP
rs1356391847 158 dbSNP
rs550789029 159 dbSNP
rs1015512445 160 dbSNP
rs781747390 165 dbSNP
rs1269525863 167 dbSNP
rs994921036 169 dbSNP
rs185210822 172 dbSNP
rs1162829774 175 dbSNP
rs1216097045 177 dbSNP
rs911762442 179 dbSNP
rs552977935 187 dbSNP
rs573174822 188 dbSNP
rs1427497942 193 dbSNP
rs570798132 194 dbSNP
rs545047136 197 dbSNP
rs770318094 200 dbSNP
rs1290275551 206 dbSNP
rs1489629271 206 dbSNP
rs953407959 209 dbSNP
rs1036411503 210 dbSNP
rs1223564549 211 dbSNP
rs374864435 213 dbSNP
rs1225533519 214 dbSNP
rs1293979512 219 dbSNP
rs1279064438 221 dbSNP
rs898866959 222 dbSNP
rs575808205 226 dbSNP
rs1215612004 238 dbSNP
rs58727022 240 dbSNP
rs1302508302 241 dbSNP
rs912441387 242 dbSNP
rs1392636090 248 dbSNP
rs1165875142 250 dbSNP
rs965683737 252 dbSNP
rs1243209076 254 dbSNP
rs552135185 258 dbSNP
rs778237016 259 dbSNP
rs1195362576 261 dbSNP
rs1182103019 263 dbSNP
rs1044832624 266 dbSNP
rs1267505054 274 dbSNP
rs539309943 277 dbSNP
rs561465315 278 dbSNP
rs936417564 279 dbSNP
rs1035865217 280 dbSNP
rs1194504363 286 dbSNP
rs896032575 287 dbSNP
rs1392177930 293 dbSNP
rs1010501515 297 dbSNP
rs774054138 302 dbSNP
rs769397890 304 dbSNP
rs1053564904 308 dbSNP
rs1020283717 311 dbSNP
rs916347550 312 dbSNP
rs1326749288 321 dbSNP
rs1390649895 331 dbSNP
rs978836668 333 dbSNP
rs1172409000 350 dbSNP
rs1345711344 352 dbSNP
rs529845077 353 dbSNP
rs953449239 356 dbSNP
rs1176432921 358 dbSNP
rs1046097268 362 dbSNP
rs1478721813 371 dbSNP
rs1249019440 375 dbSNP
rs906749058 379 dbSNP
rs1180247610 386 dbSNP
rs987688603 389 dbSNP
rs1239119532 392 dbSNP
rs7248057 394 dbSNP
rs146947327 398 dbSNP
rs1262750986 404 dbSNP
rs771114919 413 dbSNP
rs994868783 418 dbSNP
rs1219950497 420 dbSNP
rs190061398 421 dbSNP
rs137913257 429 dbSNP
rs1277739219 430 dbSNP
rs569140101 431 dbSNP
rs1377389491 435 dbSNP
rs1348553802 436 dbSNP
rs531497101 440 dbSNP
rs1008819891 443 dbSNP
rs1334386461 447 dbSNP
rs759714724 450 dbSNP
rs1415723486 459 dbSNP
rs1204614275 460 dbSNP
rs1285124795 461 dbSNP
rs1180976317 462 dbSNP
rs260463 462 dbSNP
rs760565757 467 dbSNP
rs181987411 468 dbSNP
rs545453957 473 dbSNP
rs761511052 474 dbSNP
rs1282179626 476 dbSNP
rs1223158131 480 dbSNP
rs1354242670 481 dbSNP
rs764997903 487 dbSNP
rs939132967 490 dbSNP
rs143469156 497 dbSNP
rs896015007 499 dbSNP
rs1183759733 500 dbSNP
rs916291945 510 dbSNP
rs1342941042 519 dbSNP
rs1316941402 525 dbSNP
rs1010885836 534 dbSNP
rs528242296 539 dbSNP
rs66680972 539 dbSNP
rs377600775 541 dbSNP
rs1468341961 553 dbSNP
rs1160953625 558 dbSNP
rs114643724 563 dbSNP
rs927154504 564 dbSNP
rs1413469437 565 dbSNP
rs186325438 570 dbSNP
rs927656420 576 dbSNP
rs375814720 577 dbSNP
rs1337876970 580 dbSNP
rs34332842 583 dbSNP
rs953559965 583 dbSNP
rs1488650714 587 dbSNP
rs1288135678 592 dbSNP
rs1037050205 594 dbSNP
rs1458702646 595 dbSNP
rs1009013974 601 dbSNP
rs1229682497 602 dbSNP
rs539034343 619 dbSNP
rs1404997784 620 dbSNP
rs930788736 630 dbSNP
rs1050562708 632 dbSNP
rs961943665 633 dbSNP
rs889192552 637 dbSNP
rs1453113391 639 dbSNP
rs377303954 639 dbSNP
rs368924101 640 dbSNP
rs260464 643 dbSNP
rs951967287 648 dbSNP
rs377471822 657 dbSNP
rs1018928683 658 dbSNP
rs1417708515 675 dbSNP
rs188427483 675 dbSNP
rs111260484 676 dbSNP
rs939085320 678 dbSNP
rs1478207563 679 dbSNP
rs544900810 681 dbSNP
rs1197207941 683 dbSNP
rs917400284 684 dbSNP
rs1031313886 694 dbSNP
rs1223573181 698 dbSNP
rs1305533263 699 dbSNP
rs1271905356 700 dbSNP
rs1222150949 701 dbSNP
rs1319411236 702 dbSNP
rs1403639800 704 dbSNP
rs1263077298 706 dbSNP
rs1294616493 713 dbSNP
rs1275978049 716 dbSNP
rs1439110088 717 dbSNP
rs946268045 731 dbSNP
rs1170264152 739 dbSNP
rs1324959937 743 dbSNP
rs1466286416 744 dbSNP
rs1205964547 751 dbSNP
rs1248914404 760 dbSNP
rs1425880771 766 dbSNP
rs1041914228 769 dbSNP
rs1180673043 773 dbSNP
rs540144025 777 dbSNP
rs56411850 777 dbSNP
rs779395626 779 dbSNP
rs1192820570 780 dbSNP
rs904735668 782 dbSNP
rs753281842 793 dbSNP
rs957945534 800 dbSNP
rs866976861 802 dbSNP
rs756634625 808 dbSNP
rs989277239 823 dbSNP
rs1174104540 839 dbSNP
rs1260859350 844 dbSNP
rs1000465051 854 dbSNP
rs1312239282 857 dbSNP
rs1023506097 863 dbSNP
rs1221389957 865 dbSNP
rs969121399 875 dbSNP
rs1470299149 878 dbSNP
rs1371650823 879 dbSNP
rs138215509 880 dbSNP
rs982290499 881 dbSNP
rs1402805304 888 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uguuccguauaccaugAGUCUCu 5'
                          |||||| 
Target 5' ----------------UCAGAGa 3'
 		1 - 7
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000599227.1 | 3UTR | ucagagaauucauacuggagagaaacc
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
77 hsa-miR-3921 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT118184 ZNF544 zinc finger protein 544 2 2
MIRT332934 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT442165 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT442388 CLVS2 clavesin 2 2 2
MIRT442594 SIX1 SIX homeobox 1 2 2
MIRT448015 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT448062 MMP15 matrix metallopeptidase 15 2 2
MIRT489018 C1QTNF6 C1q and TNF related 6 2 2
MIRT494457 BTG2 BTG anti-proliferation factor 2 2 2
MIRT495651 SLC35B2 solute carrier family 35 member B2 2 2
MIRT504018 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT506778 KLHL15 kelch like family member 15 2 4
MIRT507230 FOXN2 forkhead box N2 2 4
MIRT512551 MFN2 mitofusin 2 2 6
MIRT512843 A1CF APOBEC1 complementation factor 2 6
MIRT513943 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT516104 GADL1 glutamate decarboxylase like 1 2 4
MIRT519832 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT523209 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT525007 ACTN4 actinin alpha 4 2 6
MIRT528859 PKP1 plakophilin 1 2 2
MIRT529061 ZNF675 zinc finger protein 675 2 2
MIRT531720 TARS threonyl-tRNA synthetase 2 2
MIRT534038 STK4 serine/threonine kinase 4 2 2
MIRT543849 APIP APAF1 interacting protein 2 2
MIRT545865 ZNF264 zinc finger protein 264 2 4
MIRT556038 MXD1 MAX dimerization protein 1 2 2
MIRT561346 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT562706 ZNF415 zinc finger protein 415 2 2
MIRT563224 ZNF286A zinc finger protein 286A 2 2
MIRT563861 ZNF616 zinc finger protein 616 2 4
MIRT563880 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT564653 ZNF487P zinc finger protein 487 1 1
MIRT566596 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT570879 ZFP1 ZFP1 zinc finger protein 2 2
MIRT573069 TRIB1 tribbles pseudokinase 1 2 2
MIRT573940 ZNF708 zinc finger protein 708 2 2
MIRT575967 Slfn5 schlafen 5 2 5
MIRT607294 CD300E CD300e molecule 2 4
MIRT608188 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609538 ADPRH ADP-ribosylarginine hydrolase 2 2
MIRT610153 PRMT8 protein arginine methyltransferase 8 2 4
MIRT611572 SLFN5 schlafen family member 5 2 7
MIRT613336 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT616561 ZNF512B zinc finger protein 512B 2 2
MIRT617239 SPATS2 spermatogenesis associated serine rich 2 2 2
MIRT618012 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618479 IL17REL interleukin 17 receptor E like 2 2
MIRT619100 IFI44L interferon induced protein 44 like 2 2
MIRT622266 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623081 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT625622 LILRB2 leukocyte immunoglobulin like receptor B2 2 2
MIRT627845 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT630460 GMPS guanine monophosphate synthase 2 2
MIRT630525 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 4
MIRT631503 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT634538 MRPS17 mitochondrial ribosomal protein S17 2 2
MIRT638808 DCTN3 dynactin subunit 3 2 2
MIRT641304 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT648348 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT649706 ZNF175 zinc finger protein 175 2 2
MIRT652555 TLX1 T-cell leukemia homeobox 1 2 2
MIRT655563 P2RX7 purinergic receptor P2X 7 2 2
MIRT659066 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT660342 BCAT1 branched chain amino acid transaminase 1 2 2
MIRT664331 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT688935 ATXN7L3B ataxin 7 like 3B 2 2
MIRT689972 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT699515 SKIL SKI like proto-oncogene 2 2
MIRT699976 RREB1 ras responsive element binding protein 1 2 2
MIRT702675 IRS2 insulin receptor substrate 2 2 2
MIRT709358 ULK2 unc-51 like autophagy activating kinase 2 2 2
MIRT709838 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT718717 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718880 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT724106 TMEM199 transmembrane protein 199 2 2
MIRT724764 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3921 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3921 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC7901)
hsa-miR-3921 Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3921 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-3921 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-3921 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3921 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3921 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3921 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)

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