miRTarBase - #MIRT118211


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pre-miRNA Information
pre-miRNA hsa-mir-3175   
Genomic Coordinates chr15: 92904399 - 92904475
Description Homo sapiens miR-3175 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3175
Sequence 10| CGGGGAGAGAACGCAGUGACGU |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1449291045 4 dbSNP
rs372141302 4 dbSNP
rs72647784 4 dbSNP
rs1209664292 5 dbSNP
rs563454166 6 dbSNP
rs915251599 19 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KHSRP   
Synonyms FBP2, FUBP2, KSRP
Description KH-type splicing regulatory protein
Transcript NM_003685   
Expression
Putative miRNA Targets on KHSRP
3'UTR of KHSRP
(miRNA target sites are highlighted)		 
>KHSRP|NM_003685|3'UTR
   1 ATCGAATGAATGTGAACTTCTTCATCTGTGAAAAATCTTTTTTTTTTCCATTTTGTTCTGTTTGGGGGCTTCTGTTTTGT
  81 TTGGCGAGAGAGCGATGGCTGCCGTGGGGAGTACTGGGGAGCCCTCGCGGCAAGCAGGGTGGGGGGGACTTGGGGGCATG
 161 CCGGGCCCTCACTCTCTCGCCTGTTCTGTGTCTCACATGCTTTTTCTTTCAAAATTGGGATCCTTCCATGTTGAGCCAGC
 241 CAGAGAAGATAGCGAGATCTAAATCTCTGCCAAAAAAAAAAAAAAACTTAAAAATTAAAAACACAAAGAGCAAAGCAGAA
 321 CTTATAAAATTATATATATATATATTAAAAAGTCTCTATTCTTCACCCCCCAGCCTTCCTGAACCTGCCTCTCTGAGGAT
 401 AAAGCAATTCATTTTCTCCCACCCTCGGCCCTCTTGTTTTTAAAATAAACTTTTAAAAAGGAAAAAAAAAAGTCACTCTT
 481 GCTATTTCTTTTTTTTAGTTAGAGGTGGAACATTCCTTGGACCAGGTGTTGTATTGCAGGACCCCTTCCCCCAGCAGCCA
 561 AGCCCCCTCTTCTCTCCCTCCCGCCCTGGCTCAGCTCCCGCGGCCCCGCCCGTCCCCCCTCCCAGGACTGGTCTGTTGTC
 641 TTTTCATCTGTTCAAGAGGAGATTGAAACTGAAAACAAAATGAGAACAACAAAAAAAATTGTATGGCAGTTTTTACTTTT
 721 TATCGCTCGTTTTTAACTTCACAAATAAATGATAACAAAACCTCCCCGTCTGCGGGTGCTGTCTGTCTCCCCCCCTTTCC
 801 TTCCCTCCCTGTAGTTTTGAAGCGGATGTTTGTTCTTTATAGATGTTGTTTAAAAAGCCTGATAATGGTGATTGAAATTT
 881 ACAAACTTTGTGTTTTTTTTTTTTTAAGAAAAATATAAAATAGTTTTCTTCAGGCTCAATGTGCTTTCCTAACCGTGCCC
 961 CCCCCCCTTTTTTTTTTTTGTTAAATAAAGTGCTTTTTGTTTAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugCAG-UG---ACG-CA-AGAGAGGGGc 5'
            ||| :|   ||| || | ||||||| 
Target 5' ccGTCTGCGGGTGCTGTCTGTCTCCCCc 3'
 766 - 793 152.00 -22.00
2 
miRNA  3' ugcaGUGACGCAAGAGAGGGgc 5'
              || | | ||:||||||  
Target 5' aaagCAATTCATTTTCTCCCac 3'
 401 - 422 142.00 -13.70
3 
miRNA  3' ugcaGUGACGCAAGAGAGGGGc 5'
              | || | |||||||||: 
Target 5' agccCCCT-C-TTCTCTCCCTc 3'
 561 - 580 140.00 -15.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30103723 3 COSMIC
COSN31573549 4 COSMIC
COSN26981267 6 COSMIC
COSN30107427 20 COSMIC
COSN31522949 20 COSMIC
COSN19668592 24 COSMIC
COSN30188156 26 COSMIC
COSN29661453 37 COSMIC
COSN2532129 38 COSMIC
COSN31556837 108 COSMIC
COSN31587766 126 COSMIC
COSN30119348 128 COSMIC
COSN30162295 129 COSMIC
COSN30540037 180 COSMIC
COSN31490169 186 COSMIC
COSN22651174 328 COSMIC
COSN30161851 461 COSMIC
COSN20042664 462 COSMIC
COSN15904812 488 COSMIC
COSN30749700 489 COSMIC
COSN32071620 568 COSMIC
COSN21900085 582 COSMIC
COSN30749145 583 COSMIC
COSN32071700 602 COSMIC
COSN29024686 603 COSMIC
COSN32071335 613 COSMIC
COSN32069628 620 COSMIC
COSN31537411 720 COSMIC
COSN31601006 729 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs766514395 3 dbSNP
rs373531467 4 dbSNP
rs1207035169 7 dbSNP
rs1245473082 11 dbSNP
rs750674142 18 dbSNP
rs376723443 19 dbSNP
rs762122897 21 dbSNP
rs774500044 24 dbSNP
rs777193847 35 dbSNP
rs369293348 37 dbSNP
rs887002938 39 dbSNP
rs1244572971 40 dbSNP
rs761283656 41 dbSNP
rs775818254 43 dbSNP
rs771631974 47 dbSNP
rs1448503443 48 dbSNP
rs762981895 48 dbSNP
rs768870967 48 dbSNP
rs769600035 48 dbSNP
rs775569966 48 dbSNP
rs1344314387 49 dbSNP
rs1348203307 50 dbSNP
rs1225324505 58 dbSNP
rs1353208728 59 dbSNP
rs1232096264 65 dbSNP
rs1278328397 68 dbSNP
rs1046956461 70 dbSNP
rs1351321295 74 dbSNP
rs995326659 77 dbSNP
rs1237359499 79 dbSNP
rs1384427097 85 dbSNP
rs542558687 86 dbSNP
rs1451556417 87 dbSNP
rs898282332 93 dbSNP
rs1259816878 94 dbSNP
rs1484842669 99 dbSNP
rs1332625097 102 dbSNP
rs573855333 103 dbSNP
rs1476346075 104 dbSNP
rs1166032581 106 dbSNP
rs1409396257 109 dbSNP
rs1414782319 110 dbSNP
rs1177990159 111 dbSNP
rs1039471623 112 dbSNP
rs942407857 121 dbSNP
rs1298270172 122 dbSNP
rs890806964 124 dbSNP
rs557212204 126 dbSNP
rs1387221421 127 dbSNP
rs1184435955 128 dbSNP
rs373157908 129 dbSNP
rs924175927 137 dbSNP
rs141757137 141 dbSNP
rs1448745056 142 dbSNP
rs1447468029 143 dbSNP
rs557466259 147 dbSNP
rs990922083 156 dbSNP
rs1195226473 158 dbSNP
rs534653817 158 dbSNP
rs1393111675 160 dbSNP
rs1237947004 162 dbSNP
rs961040728 163 dbSNP
rs1360972039 167 dbSNP
rs780402105 171 dbSNP
rs1398405486 178 dbSNP
rs1035039670 179 dbSNP
rs1326326049 179 dbSNP
rs893858425 180 dbSNP
rs565316158 181 dbSNP
rs1306071472 183 dbSNP
rs999638997 186 dbSNP
rs1234028646 188 dbSNP
rs1244719603 191 dbSNP
rs1232254048 196 dbSNP
rs1353133320 197 dbSNP
rs1376548074 198 dbSNP
rs1025559789 200 dbSNP
rs1283696766 201 dbSNP
rs995378857 210 dbSNP
rs1215547314 217 dbSNP
rs1251076112 220 dbSNP
rs1453500792 223 dbSNP
rs1179056468 227 dbSNP
rs1365161342 228 dbSNP
rs1468318447 230 dbSNP
rs898336335 237 dbSNP
rs1390902038 252 dbSNP
rs1462576511 253 dbSNP
rs555997081 254 dbSNP
rs535788720 255 dbSNP
rs1433290019 256 dbSNP
rs1440570705 258 dbSNP
rs1310511029 261 dbSNP
rs1346208975 264 dbSNP
rs181761973 265 dbSNP
rs1018088834 269 dbSNP
rs201433687 270 dbSNP
rs1418479076 271 dbSNP
rs1357073129 272 dbSNP
rs1367456141 272 dbSNP
rs1164304787 274 dbSNP
rs1006655846 279 dbSNP
rs890848235 281 dbSNP
rs1188544530 282 dbSNP
rs1252487576 283 dbSNP
rs1475612795 284 dbSNP
rs1262293655 285 dbSNP
rs1475881088 286 dbSNP
rs1050804927 287 dbSNP
rs1328360317 287 dbSNP
rs1340763872 287 dbSNP
rs1356371184 287 dbSNP
rs1416295407 287 dbSNP
rs35757137 287 dbSNP
rs397796586 287 dbSNP
rs1214279843 288 dbSNP
rs138633372 294 dbSNP
rs1291807936 295 dbSNP
rs1334067112 295 dbSNP
rs902805064 302 dbSNP
rs1253022886 306 dbSNP
rs1337129725 308 dbSNP
rs1195045131 312 dbSNP
rs1043953586 313 dbSNP
rs1185115053 319 dbSNP
rs1256269052 320 dbSNP
rs1041105839 321 dbSNP
rs1475157256 324 dbSNP
rs946930285 325 dbSNP
rs533246756 326 dbSNP
rs916754712 328 dbSNP
rs991366225 332 dbSNP
rs1438112176 333 dbSNP
rs1402616812 334 dbSNP
rs1383590964 339 dbSNP
rs1330159468 341 dbSNP
rs1311131322 344 dbSNP
rs189845233 346 dbSNP
rs983506069 346 dbSNP
rs1226394936 347 dbSNP
rs1163218594 349 dbSNP
rs1349591451 354 dbSNP
rs1208349540 356 dbSNP
rs1394957394 359 dbSNP
rs911821821 361 dbSNP
rs950693571 362 dbSNP
rs1012599758 365 dbSNP
rs1488293082 365 dbSNP
rs1050645830 366 dbSNP
rs1264411774 367 dbSNP
rs1192917109 368 dbSNP
rs1436985637 369 dbSNP
rs1027620620 370 dbSNP
rs1435702463 372 dbSNP
rs973996583 373 dbSNP
rs547581070 379 dbSNP
rs773993674 383 dbSNP
rs962593650 384 dbSNP
rs1441626184 385 dbSNP
rs779363674 387 dbSNP
rs1475378224 388 dbSNP
rs1007115954 389 dbSNP
rs890906187 395 dbSNP
rs920311815 395 dbSNP
rs15383 397 dbSNP
rs1317166999 407 dbSNP
rs1217282730 408 dbSNP
rs1258506529 410 dbSNP
rs1218415821 415 dbSNP
rs1437236237 416 dbSNP
rs973116072 419 dbSNP
rs940470579 422 dbSNP
rs1254183922 423 dbSNP
rs1248288558 424 dbSNP
rs1192180454 425 dbSNP
rs766149298 426 dbSNP
rs1289102523 427 dbSNP
rs999184611 430 dbSNP
rs370894402 436 dbSNP
rs762929023 451 dbSNP
rs368278157 455 dbSNP
rs561965000 455 dbSNP
rs1396637447 456 dbSNP
rs1316935796 459 dbSNP
rs1438377977 459 dbSNP
rs35768476 460 dbSNP
rs75985763 460 dbSNP
rs1217215218 461 dbSNP
rs1325030407 467 dbSNP
rs1326146757 469 dbSNP
rs1011125742 472 dbSNP
rs375598365 472 dbSNP
rs1233402163 475 dbSNP
rs1274304654 476 dbSNP
rs1470259704 480 dbSNP
rs1284456211 483 dbSNP
rs1179104874 490 dbSNP
rs1481072526 490 dbSNP
rs1386775382 497 dbSNP
rs1055328346 503 dbSNP
rs773052511 506 dbSNP
rs1221367016 513 dbSNP
rs1359461412 515 dbSNP
rs542876916 516 dbSNP
rs1212694281 521 dbSNP
rs1279205275 524 dbSNP
rs991366238 526 dbSNP
rs1048279799 531 dbSNP
rs1444117642 533 dbSNP
rs1361212248 534 dbSNP
rs529239803 534 dbSNP
rs1296052235 537 dbSNP
rs1372189696 541 dbSNP
rs1414844500 548 dbSNP
rs1270744016 549 dbSNP
rs1432596382 560 dbSNP
rs563452736 563 dbSNP
rs1302764584 565 dbSNP
rs1425552649 566 dbSNP
rs1367459034 567 dbSNP
rs1289803563 568 dbSNP
rs1308378107 568 dbSNP
rs1207100621 569 dbSNP
rs1231344653 574 dbSNP
rs752899836 577 dbSNP
rs144697112 578 dbSNP
rs1409851646 579 dbSNP
rs755865840 582 dbSNP
rs1188843369 583 dbSNP
rs748141502 586 dbSNP
rs1353531313 590 dbSNP
rs1268698371 593 dbSNP
rs911116467 594 dbSNP
rs1490420160 597 dbSNP
rs541993293 599 dbSNP
rs955379789 600 dbSNP
rs1029455702 601 dbSNP
rs564168292 602 dbSNP
rs999238560 604 dbSNP
rs748187164 605 dbSNP
rs758511852 607 dbSNP
rs750536697 608 dbSNP
rs185368013 611 dbSNP
rs1405739020 612 dbSNP
rs1385942254 614 dbSNP
rs1158110050 615 dbSNP
rs1347649001 616 dbSNP
rs1296720472 617 dbSNP
rs142423316 618 dbSNP
rs555102950 619 dbSNP
rs1173149803 620 dbSNP
rs1389392843 620 dbSNP
rs1435113569 621 dbSNP
rs1468702361 624 dbSNP
rs1428978694 629 dbSNP
rs1177627638 630 dbSNP
rs1003759875 640 dbSNP
rs1433503888 645 dbSNP
rs906704499 648 dbSNP
rs1433583239 650 dbSNP
rs1268773165 654 dbSNP
rs1268978552 662 dbSNP
rs760897427 663 dbSNP
rs1480016575 665 dbSNP
rs1346055495 671 dbSNP
rs1232965080 672 dbSNP
rs1200389556 678 dbSNP
rs1285129545 681 dbSNP
rs1321369094 681 dbSNP
rs1189933817 682 dbSNP
rs1262228609 684 dbSNP
rs1223879165 687 dbSNP
rs57918812 690 dbSNP
rs1247343100 693 dbSNP
rs1305129720 693 dbSNP
rs879929660 695 dbSNP
rs767842048 696 dbSNP
rs1299998429 698 dbSNP
rs745860323 699 dbSNP
rs780848156 699 dbSNP
rs902634358 699 dbSNP
rs1398457563 700 dbSNP
rs1451031443 701 dbSNP
rs1319084631 702 dbSNP
rs376474045 704 dbSNP
rs1442073277 706 dbSNP
rs770820682 706 dbSNP
rs1471156023 707 dbSNP
rs1240926777 720 dbSNP
rs920660443 725 dbSNP
rs1376316532 726 dbSNP
rs866509806 728 dbSNP
rs1222166424 729 dbSNP
rs1267371259 737 dbSNP
rs1468896584 738 dbSNP
rs1019592618 739 dbSNP
rs943341138 744 dbSNP
rs1450670693 747 dbSNP
rs1406457700 751 dbSNP
rs1008235038 752 dbSNP
rs1365216509 756 dbSNP
rs1468114558 759 dbSNP
rs1157839624 761 dbSNP
rs911179075 762 dbSNP
rs576374342 767 dbSNP
rs955284069 768 dbSNP
rs922440673 773 dbSNP
rs1388957952 774 dbSNP
rs543928151 775 dbSNP
rs1386573162 781 dbSNP
rs776763108 783 dbSNP
rs1337773747 787 dbSNP
rs1440080823 788 dbSNP
rs1287852340 789 dbSNP
rs966456308 789 dbSNP
rs977869722 789 dbSNP
rs868654870 791 dbSNP
rs768861049 792 dbSNP
rs931922819 793 dbSNP
rs1010569319 794 dbSNP
rs1435762120 795 dbSNP
rs1180824253 796 dbSNP
rs959301205 796 dbSNP
rs1491489963 797 dbSNP
rs1190618272 800 dbSNP
rs898982661 804 dbSNP
rs1378007462 805 dbSNP
rs1457673808 806 dbSNP
rs1037539320 808 dbSNP
rs940408427 810 dbSNP
rs1257247323 816 dbSNP
rs906763687 820 dbSNP
rs62107577 823 dbSNP
rs556327996 824 dbSNP
rs1026510158 835 dbSNP
rs993654791 835 dbSNP
rs981717857 836 dbSNP
rs1339855430 837 dbSNP
rs1262995460 845 dbSNP
rs1218061992 850 dbSNP
rs771014326 851 dbSNP
rs949092660 852 dbSNP
rs747288961 854 dbSNP
rs943425301 864 dbSNP
rs1248371800 866 dbSNP
rs889121231 869 dbSNP
rs1486346804 870 dbSNP
rs1208124148 871 dbSNP
rs1254657218 872 dbSNP
rs372415969 878 dbSNP
rs916259892 880 dbSNP
rs1194339812 883 dbSNP
rs933918519 887 dbSNP
rs189359496 888 dbSNP
rs1394032574 889 dbSNP
rs1301211849 890 dbSNP
rs528107957 890 dbSNP
rs747994346 890 dbSNP
rs1401406272 891 dbSNP
rs1386925309 892 dbSNP
rs1297658189 893 dbSNP
rs570958113 893 dbSNP
rs547839359 894 dbSNP
rs1303621023 895 dbSNP
rs915037354 895 dbSNP
rs989198181 895 dbSNP
rs959126389 896 dbSNP
rs1033784069 897 dbSNP
rs534052028 900 dbSNP
rs1444823685 901 dbSNP
rs113170492 906 dbSNP
rs1264483943 906 dbSNP
rs1455799975 906 dbSNP
rs398059536 906 dbSNP
rs879249125 906 dbSNP
rs1367499717 907 dbSNP
rs1185030355 913 dbSNP
rs1422423925 914 dbSNP
rs368944741 915 dbSNP
rs1377081432 916 dbSNP
rs1264384539 923 dbSNP
rs1290513815 927 dbSNP
rs1386382692 928 dbSNP
rs1434065883 930 dbSNP
rs1326382514 932 dbSNP
rs1372724763 934 dbSNP
rs1217179516 935 dbSNP
rs1194940506 937 dbSNP
rs1316921446 941 dbSNP
rs568429029 944 dbSNP
rs1270524210 951 dbSNP
rs1283908658 954 dbSNP
rs1224853766 955 dbSNP
rs1357190907 957 dbSNP
rs1189623676 958 dbSNP
rs1265061502 959 dbSNP
rs1242957614 960 dbSNP
rs1419695427 960 dbSNP
rs1161443646 961 dbSNP
rs1327973997 962 dbSNP
rs1278626285 963 dbSNP
rs1409625402 965 dbSNP
rs1456705817 965 dbSNP
rs1428066684 966 dbSNP
rs548324400 966 dbSNP
rs1396335002 967 dbSNP
rs1434036527 968 dbSNP
rs551871526 968 dbSNP
rs60365888 968 dbSNP
rs1491303870 969 dbSNP
rs73920661 969 dbSNP
rs1219848285 970 dbSNP
rs1323836622 970 dbSNP
rs1265057122 971 dbSNP
rs1399272284 976 dbSNP
rs1184438128 978 dbSNP
rs1481107622 978 dbSNP
rs1199712372 980 dbSNP
rs1249789720 980 dbSNP
rs1403341530 980 dbSNP
rs67354590 980 dbSNP
rs67603778 980 dbSNP
rs74266717 980 dbSNP
rs796881092 980 dbSNP
rs903056222 980 dbSNP
rs1338379030 981 dbSNP
rs1463252893 982 dbSNP
rs1304922672 983 dbSNP
rs1026557846 986 dbSNP
rs1405428110 986 dbSNP
rs1294388903 990 dbSNP
rs1414898107 990 dbSNP
rs754947108 991 dbSNP
rs1226938092 994 dbSNP
rs1161093931 1003 dbSNP
rs1312549411 1009 dbSNP
rs1463206269 1009 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugcagugacgcaagAGAGGGGc 5'
                        ||||||| 
Target 5' --------------UCUCCCCc 3'
 		1 - 8
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000398148.3 | 3UTR | UCUCCCCCCCUUUCCUUCCCUCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
Click to see details
208 hsa-miR-3175 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT118211 KHSRP KH-type splicing regulatory protein 2 2
MIRT131222 ATG2A autophagy related 2A 2 2
MIRT143733 CCL22 C-C motif chemokine ligand 22 2 2
MIRT151435 ZBTB7A zinc finger and BTB domain containing 7A 2 4
MIRT191759 ZNF410 zinc finger protein 410 2 2
MIRT267302 TMEM109 transmembrane protein 109 2 2
MIRT273435 DAZAP2 DAZ associated protein 2 2 4
MIRT286061 HIC1 HIC ZBTB transcriptional repressor 1 2 2
MIRT288597 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT316768 FOXC1 forkhead box C1 2 4
MIRT331065 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT398528 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT443842 RGS6 regulator of G protein signaling 6 2 2
MIRT446200 GTPBP4 GTP binding protein 4 2 2
MIRT448039 SFRP1 secreted frizzled related protein 1 2 2
MIRT451946 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453239 FTSJ3 FtsJ RNA methyltransferase homolog 3 2 2
MIRT453501 ARRB1 arrestin beta 1 2 2
MIRT453541 PRR12 proline rich 12 2 2
MIRT453953 ENTHD1 ENTH domain containing 1 2 2
MIRT454209 HLA-A major histocompatibility complex, class I, A 2 2
MIRT455501 C6orf106 chromosome 6 open reading frame 106 2 2
MIRT455620 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 10
MIRT455631 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 10
MIRT456074 AFF2 AF4/FMR2 family member 2 2 6
MIRT456149 TTF2 transcription termination factor 2 2 2
MIRT456309 ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 2 2
MIRT456444 TMEM81 transmembrane protein 81 2 2
MIRT456685 LDB1 LIM domain binding 1 2 2
MIRT457516 ZMAT5 zinc finger matrin-type 5 2 2
MIRT457599 IDS iduronate 2-sulfatase 2 2
MIRT457949 ABCC5 ATP binding cassette subfamily C member 5 2 6
MIRT458593 KCTD2 potassium channel tetramerization domain containing 2 2 2
MIRT459505 TACR3 tachykinin receptor 3 2 2
MIRT459687 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT459914 HHIP hedgehog interacting protein 2 11
MIRT460610 FEM1A fem-1 homolog A 2 2
MIRT460646 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT461454 SLC19A3 solute carrier family 19 member 3 2 2
MIRT461909 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT462059 CCDC77 coiled-coil domain containing 77 2 4
MIRT462404 RBM28 RNA binding motif protein 28 2 2
MIRT462589 MYL12A myosin light chain 12A 2 2
MIRT462770 ZNF8 zinc finger protein 8 2 2
MIRT462991 ZNF740 zinc finger protein 740 2 2
MIRT463680 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT464112 VPS35 VPS35, retromer complex component 2 2
MIRT464414 UNC13A unc-13 homolog A 2 6
MIRT464608 UBE4B ubiquitination factor E4B 2 2
MIRT465679 TNPO2 transportin 2 2 2
MIRT467225 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT469316 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469604 RALGAPA2 Ral GTPase activating protein catalytic alpha subunit 2 2 2
MIRT469655 RAC1 Rac family small GTPase 1 2 2
MIRT469744 RAB2B RAB2B, member RAS oncogene family 2 2
MIRT469947 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT470140 PSME3 proteasome activator subunit 3 2 2
MIRT473142 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT473287 MFRP membrane frizzled-related protein 2 2
MIRT473379 MBD4 methyl-CpG binding domain 4, DNA glycosylase 2 6
MIRT473661 MARCKSL1 MARCKS like 1 2 2
MIRT475256 IGF1R insulin like growth factor 1 receptor 2 2
MIRT475361 ICOSLG inducible T-cell costimulator ligand 2 4
MIRT475662 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT476524 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT476572 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT477624 EFNA1 ephrin A1 2 2
MIRT478125 DIRAS1 DIRAS family GTPase 1 2 2
MIRT479971 CARD10 caspase recruitment domain family member 10 2 2
MIRT480144 CALR calreticulin 2 2
MIRT480349 C5orf24 chromosome 5 open reading frame 24 2 2
MIRT480402 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480741 BNC2 basonuclin 2 2 8
MIRT481987 AMOTL2 angiomotin like 2 2 2
MIRT482650 FAM195B MAPK regulated corepressor interacting protein 1 2 4
MIRT482809 TRAF6 TNF receptor associated factor 6 2 2
MIRT482945 ZNF561 zinc finger protein 561 2 6
MIRT482987 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483123 ONECUT3 one cut homeobox 3 2 4
MIRT483253 CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 2 4
MIRT483580 SLC26A9 solute carrier family 26 member 9 2 2
MIRT483704 ASPH aspartate beta-hydroxylase 2 2
MIRT483932 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484140 LRRC45 leucine rich repeat containing 45 2 4
MIRT484195 SUMO1 small ubiquitin-like modifier 1 2 4
MIRT484353 GATA6 GATA binding protein 6 2 12
MIRT484472 DDX6 DEAD-box helicase 6 2 2
MIRT484544 BARHL1 BarH like homeobox 1 2 6
MIRT484572 HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 2 2
MIRT485265 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT485376 MSN moesin 2 4
MIRT485763 B4GALT5 beta-1,4-galactosyltransferase 5 2 2
MIRT485882 AGO2 argonaute 2, RISC catalytic component 2 17
MIRT486242 FASTK Fas activated serine/threonine kinase 2 2
MIRT486431 NDUFA5 NADH:ubiquinone oxidoreductase subunit A5 2 2
MIRT486569 ZNF619 zinc finger protein 619 2 2
MIRT486608 METTL6 methyltransferase like 6 2 2
MIRT487442 TFAP2B transcription factor AP-2 beta 2 4
MIRT487577 FAM83H family with sequence similarity 83 member H 2 4
MIRT487812 PER3 period circadian clock 3 2 2
MIRT487944 ISCA1 iron-sulfur cluster assembly 1 2 2
MIRT487952 IQSEC2 IQ motif and Sec7 domain 2 2 2
MIRT488011 GDF5OS growth differentiation factor 5 opposite strand 2 2
MIRT488311 LDOC1 LDOC1, regulator of NFKB signaling 2 2
MIRT488639 HAND2 heart and neural crest derivatives expressed 2 2 2
MIRT488651 ELAVL3 ELAV like RNA binding protein 3 2 2
MIRT488683 NAT9 N-acetyltransferase 9 (putative) 2 2
MIRT488846 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT488970 REXO2 RNA exonuclease 2 2 2
MIRT489002 FBXO40 F-box protein 40 2 2
MIRT489038 PRPF4B pre-mRNA processing factor 4B 2 2
MIRT489167 ANKRD45 ankyrin repeat domain 45 2 2
MIRT489221 ASCL2 achaete-scute family bHLH transcription factor 2 2 4
MIRT489356 SYNGR1 synaptogyrin 1 2 4
MIRT489373 RAB11B RAB11B, member RAS oncogene family 2 6
MIRT489526 MRE11A MRE11 homolog, double strand break repair nuclease 2 14
MIRT490071 PRRT2 proline rich transmembrane protein 2 2 2
MIRT490275 ZNF562 zinc finger protein 562 2 4
MIRT490696 FSTL4 follistatin like 4 2 2
MIRT490778 PSMD3 proteasome 26S subunit, non-ATPase 3 2 2
MIRT490854 UPK2 uroplakin 2 2 2
MIRT491048 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT491123 PTPRE protein tyrosine phosphatase, receptor type E 2 2
MIRT491161 LRP3 LDL receptor related protein 3 2 2
MIRT491506 CREBL2 cAMP responsive element binding protein like 2 2 2
MIRT491532 HDAC5 histone deacetylase 5 2 2
MIRT491699 PDZD4 PDZ domain containing 4 2 2
MIRT491949 VPS52 VPS52, GARP complex subunit 2 2
MIRT492226 SLC48A1 solute carrier family 48 member 1 2 2
MIRT492278 SHISA6 shisa family member 6 2 4
MIRT492472 RASD1 ras related dexamethasone induced 1 2 4
MIRT492480 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT492498 RANBP10 RAN binding protein 10 2 4
MIRT492565 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492702 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT492916 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT493020 NACC1 nucleus accumbens associated 1 2 2
MIRT493218 MEX3A mex-3 RNA binding family member A 2 2
MIRT493313 LIMD2 LIM domain containing 2 2 2
MIRT493410 KDM6B lysine demethylase 6B 2 2
MIRT493451 ITFG3 family with sequence similarity 234 member A 2 2
MIRT494028 DUSP7 dual specificity phosphatase 7 2 4
MIRT494329 CASKIN1 CASK interacting protein 1 2 2
MIRT496564 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT496771 ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 2 2
MIRT496973 RPS6KA2 ribosomal protein S6 kinase A2 2 2
MIRT497038 DYRK1B dual specificity tyrosine phosphorylation regulated kinase 1B 2 2
MIRT498913 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT499006 CCDC50 coiled-coil domain containing 50 2 2
MIRT499637 CREB3L2 cAMP responsive element binding protein 3 like 2 2 2
MIRT501700 PCGF3 polycomb group ring finger 3 2 6
MIRT502230 HOXC6 homeobox C6 2 2
MIRT502655 CTC1 CST telomere replication complex component 1 2 13
MIRT506246 PER1 period circadian clock 1 2 8
MIRT506430 NAGK N-acetylglucosamine kinase 2 6
MIRT507336 FAM168A family with sequence similarity 168 member A 2 2
MIRT507781 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT510062 C12orf49 chromosome 12 open reading frame 49 2 4
MIRT511935 FAM127B retrotransposon Gag like 8A 2 2
MIRT513037 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT513518 YIPF4 Yip1 domain family member 4 2 6
MIRT522612 MAP7D1 MAP7 domain containing 1 2 4
MIRT527162 ADRA2B adrenoceptor alpha 2B 2 2
MIRT535350 PFN1 profilin 1 2 2
MIRT536734 IER5 immediate early response 5 2 4
MIRT538505 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT544643 PHF8 PHD finger protein 8 2 4
MIRT544856 MYH2 myosin heavy chain 2 2 4
MIRT568898 ATP6V1B1 ATPase H+ transporting V1 subunit B1 2 2
MIRT568949 RUNX3 runt related transcription factor 3 2 2
MIRT568971 CACNA1C calcium voltage-gated channel subunit alpha1 C 2 2
MIRT569037 IL21R interleukin 21 receptor 2 2
MIRT569310 CC2D1B coiled-coil and C2 domain containing 1B 2 2
MIRT569721 GPR173 G protein-coupled receptor 173 2 2
MIRT569765 SAMD14 sterile alpha motif domain containing 14 2 2
MIRT569857 KRT80 keratin 80 2 2
MIRT569867 KLK10 kallikrein related peptidase 10 2 2
MIRT569914 PCSK9 proprotein convertase subtilisin/kexin type 9 2 2
MIRT570060 CPNE2 copine 2 2 2
MIRT570307 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT570982 RGS19 regulator of G protein signaling 19 2 2
MIRT571025 CLSTN1 calsyntenin 1 2 2
MIRT573215 NAT10 N-acetyltransferase 10 2 2
MIRT574633 LPCAT3 lysophosphatidylcholine acyltransferase 3 2 2
MIRT574690 HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2 2
MIRT575732 Hhip Hedgehog-interacting protein 2 7
MIRT575837 Ago2 argonaute RISC catalytic subunit 2 2 10
MIRT631303 CBS cystathionine-beta-synthase 2 2
MIRT647750 SAMD9L sterile alpha motif domain containing 9 like 2 2
MIRT648323 PLIN1 perilipin 1 2 2
MIRT649339 HEXA hexosaminidase subunit alpha 2 2
MIRT649994 MSI1 musashi RNA binding protein 1 2 2
MIRT661786 NLRC3 NLR family CARD domain containing 3 2 2
MIRT665992 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT667177 NR2F6 nuclear receptor subfamily 2 group F member 6 2 4
MIRT667386 MOB1B MOB kinase activator 1B 2 2
MIRT680929 EVC EvC ciliary complex subunit 1 2 2
MIRT691870 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT693258 HBS1L HBS1 like translational GTPase 2 2
MIRT693490 MOB3A MOB kinase activator 3A 2 2
MIRT696099 SETD1A SET domain containing 1A 2 2
MIRT697955 TSPYL1 TSPY like 1 2 2
MIRT699481 SLC10A6 solute carrier family 10 member 6 2 2
MIRT708274 ZNF101 zinc finger protein 101 2 2
MIRT712147 TAOK1 TAO kinase 1 2 2
MIRT717122 SOWAHA sosondowah ankyrin repeat domain family member A 2 2
MIRT717643 HLX H2.0 like homeobox 2 2
MIRT755336 DCAF1 DDB1 and CUL4 associated factor 1 6 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3175 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-mir-3175 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3175 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-miR-3175 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-3175 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-3175 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PATU8988)
hsa-miR-3175 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3175 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3175 Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3175 Temozolomide 5394 NSC362856 approved sensitive High Glioblastoma cell line (U251)
hsa-mir-3175 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-3175 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-3175 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-3175 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-3175 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-3175 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-3175 Cisplatin 5460033 NSC119875 approved sensitive cell line (BGC-823)
hsa-miR-3175 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-3175 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-3175 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-3175 Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-3175 Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-3175 Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-3175 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-3175 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-3175 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3175 Neoadjuvant chemotherapy resistant tissue (breast cancer)

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