miRTarBase - #MIRT129470


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pre-miRNA Information
pre-miRNA hsa-mir-4672   
Genomic Coordinates chr9: 127869415 - 127869495
Description Homo sapiens miR-4672 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4672
Sequence 51| UUACACAGCUGGACAGAGGCA |71
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1234304182 2 dbSNP
rs1012722802 6 dbSNP
rs1212523496 9 dbSNP
rs1027978850 10 dbSNP
rs1212553533 14 dbSNP
rs895240447 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CHEK1   
Synonyms CHK1
Description checkpoint kinase 1
Transcript NM_001114122   
Other Transcripts NM_001114121 , NM_001274   
Expression
Putative miRNA Targets on CHEK1
3'UTR of CHEK1
(miRNA target sites are highlighted)		 
>CHEK1|NM_001114122|3'UTR
   1 TCGGACCATCGGCTCTGGGGAATCCTGGTGAATATAGTGCTGCTATGTTGACATTATTCTTCCTAGAGAAGATTATCCTG
  81 TCCTGCAAACTGCAAATAGTAGTTCCTGAAGTGTTCACTTCCCTGTTTATCCAAACATCTTCCAATTTATTTTGTTTGTT
 161 CGGCATACAAATAATACCTATATCTTAATTGTAAGCAAAACTTTGGGGAAAGGATGAATAGAATTCATTTGATTATTTCT
 241 TCATGTGTGTTTAGTATCTGAATTTGAAACTCATCTGGTGGAAACCAAGTTTCAGGGGACATGAGTTTTCCAGCTTTTAT
 321 ACACACGTATCTCATTTTTATCAAAACATTTTGTTTAATTCAAAAAGTACATATTCCATGTTGATTTAATTCTAAGATGA
 401 ACCAATAAAGACATAATTCTTGTGACTTTTGGACAGTAGATTTATCAGTCTGTGAAGCGAAGCCAGCTTCAAAACATATC
 481 CCCAAGATTTGTACTTATATTTTCAAAAGGGCCTGGCCAGTTATATAAACCTGTTTTTGAATTATAATGATTAATTAAAA
 561 TTGCAAGTAGGTGTTTTTTCCAGTGTAGTTAGTAAAATACTTGTATTTTACAGTGTTGCATAAACTCTAGTGCTTAACTA
 641 ACTTTACTCTAAAAATTACTGTTGAACATCTTAAATATTTTTCTATATTTTCTACTTTCATAGCCATATTTTAACCTTTT
 721 CAACTTACTGGTGACCAAGCTTTTAGGTGATAAAGAATAAAAGAGGGAAGGGAAGAGTAAGGAAGCTATAAGAAAAATAG
 801 ATCTGATTCTTTGTTCCTTTACCTGTTAGACTTACAAAAAGTTTGTTTTTCTAATAAAATTTGTATCAACTTTGGGGCAT
 881 ATTAGGTTGAGGCCTTGGCTCCTGCCTGTAGTCCCAGCTACTTAGGAGGCTGAGAGAGGAGGATCGCGTGAACCTGGAAG
 961 TTTGAGGCTGTAGTGAGCTATGATTGCACCAGTGCACTCCAGCTTGGATGACAGAGTAAGACCCTACCTCTAATAAAAAT
1041 TTTTAAAATTGTAAAACATTATAAAATTAATCAGTTATTTTAATCTGAAGCCAAGAACATGTAGAATGTTATGATTAGAG
1121 TTTATCACATATTAATGTATACTGGCAAATTGTGTTACTGGAGTATACCCATAGGAGGAATAAATTCAAACCTGTTTTAT
1201 TTATTTGAACCTATTTACGGTATGCTTAAGAATTGAATCAGTATAAATTCTCAAATATGGGAGAAATTTTGTTCTTGAGA
1281 ATTATCTGAGTCATTAATATTTTTCAAAAACAGCTCTCACTGACTTGAACCTCTTCTGTAAGCTCTAACCTTTTACCTGC
1361 TTTACATTTCCACTTGAATGTCTAGTAGGCATCTCTTGACCAAAAACAGCTTTTGATTCCTGTTCTCCAACCTGTTCCTC
1441 TCCTAGTTTTCTCCATCTCAGAAATGTTACTTCCTCTGCAAAGTCTTTCCCTGACTTATCTAAAATAATAACCTCCTCTG
1521 TTTGCTGTGGGAATTTGTATAGAATGGTGGGAAAATTTCAAGTTTCATATTTGGATTAGCTCTGACATTTATTTATCTGA
1601 ACACTGGTAATTGCCTCAGTAAAGACACTGATAATAAGTACCTTTTAGAGTTATTTTAATCTTTAATGCTTTAATGTGTA
1681 GGAAGAGTATAGTGTCCTGTTTTGCACAGAAAGGCATTCTGTAAATAATAAGTTGCCTTAATTTTCCTGTAATGTTCATT
1761 ATATTGTTGTGGGAAGGTATTTACTCCTATTATTAAAAATAAAAATGTGTAAAATTTACTACCTGAAAAAAAAAAAAAAA
1841 AAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acGGAGACAGGUCGACACauu 5'
            |||||||:: ||||||   
Target 5' ctCCTCTGTTT-GCTGTGgga 3'
 1513 - 1532 134.00 -21.72
2 
miRNA  3' acggAGACAGGUCGACACAUu 5'
              |:| || : ||||| | 
Target 5' tagaTTTATCAGTCTGTGAAg 3'
 437 - 457 121.00 -9.42
3 
miRNA  3' acggaGACAGGUCGACACAuu 5'
               ||| | | :|||||  
Target 5' gtataCTGGCAAATTGTGTta 3'
 1137 - 1157 120.00 -9.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26575252 4 COSMIC
COSN26556998 13 COSMIC
COSN31600859 24 COSMIC
COSN30158938 26 COSMIC
COSN30179292 28 COSMIC
COSN30179290 29 COSMIC
COSN31613997 36 COSMIC
COSN26970625 58 COSMIC
COSN30460365 84 COSMIC
COSN31564405 127 COSMIC
COSN26671781 155 COSMIC
COSN31605508 162 COSMIC
COSN1128439 371 COSMIC
COSN20108960 376 COSMIC
COSN8736231 935 COSMIC
COSN25658961 1250 COSMIC
COSN27293215 1826 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1461079315 2 dbSNP
rs746474609 3 dbSNP
rs373998065 4 dbSNP
rs1032047014 5 dbSNP
rs780645711 8 dbSNP
rs747973479 11 dbSNP
rs748831574 12 dbSNP
rs749279821 14 dbSNP
rs1379752146 17 dbSNP
rs573744071 21 dbSNP
rs375887872 23 dbSNP
rs1453372998 25 dbSNP
rs1177289255 27 dbSNP
rs760632598 31 dbSNP
rs1296278154 34 dbSNP
rs764381233 37 dbSNP
rs776659228 44 dbSNP
rs1397834579 48 dbSNP
rs769434607 53 dbSNP
rs9282658 62 dbSNP
rs952890763 80 dbSNP
rs1383282654 86 dbSNP
rs1182803697 88 dbSNP
rs1285677542 90 dbSNP
rs1444978164 94 dbSNP
rs148807246 96 dbSNP
rs1202753914 98 dbSNP
rs1257439035 100 dbSNP
rs1260282320 103 dbSNP
rs868300535 112 dbSNP
rs1018498934 117 dbSNP
rs528501689 119 dbSNP
rs1313514770 124 dbSNP
rs976752552 128 dbSNP
rs547243050 132 dbSNP
rs373169887 137 dbSNP
rs1245738497 139 dbSNP
rs1185444197 141 dbSNP
rs566608597 144 dbSNP
rs967472656 162 dbSNP
rs1440480505 163 dbSNP
rs545410689 165 dbSNP
rs961200994 167 dbSNP
rs184393295 168 dbSNP
rs1288996773 181 dbSNP
rs925778195 182 dbSNP
rs1363674707 190 dbSNP
rs1433947874 227 dbSNP
rs1162802614 236 dbSNP
rs1358449867 251 dbSNP
rs1369909741 256 dbSNP
rs937212660 257 dbSNP
rs1303399900 270 dbSNP
rs530886491 273 dbSNP
rs1194524971 286 dbSNP
rs1401362524 295 dbSNP
rs1055553794 300 dbSNP
rs551019927 302 dbSNP
rs762754025 303 dbSNP
rs917138297 311 dbSNP
rs567785939 320 dbSNP
rs1377194929 325 dbSNP
rs142447277 327 dbSNP
rs1040471427 328 dbSNP
rs1036004503 330 dbSNP
rs546900560 335 dbSNP
rs1343032866 342 dbSNP
rs897513387 351 dbSNP
rs901934954 368 dbSNP
rs1405549905 372 dbSNP
rs141464656 372 dbSNP
rs113628894 374 dbSNP
rs199723723 374 dbSNP
rs3731480 374 dbSNP
rs201914580 377 dbSNP
rs1165988339 384 dbSNP
rs1461266556 393 dbSNP
rs994580634 400 dbSNP
rs1171589699 413 dbSNP
rs778999496 414 dbSNP
rs190098261 424 dbSNP
rs746593482 427 dbSNP
rs566817329 433 dbSNP
rs1257116570 434 dbSNP
rs892931725 435 dbSNP
rs1483176648 440 dbSNP
rs1339090288 441 dbSNP
rs1258323332 445 dbSNP
rs181773130 447 dbSNP
rs1198805611 460 dbSNP
rs1320960403 464 dbSNP
rs1011511727 470 dbSNP
rs1007031214 474 dbSNP
rs1022875058 476 dbSNP
rs557311968 477 dbSNP
rs867477773 481 dbSNP
rs571357048 485 dbSNP
rs536760417 494 dbSNP
rs1458257673 495 dbSNP
rs1390626647 505 dbSNP
rs1035314960 512 dbSNP
rs1378667515 517 dbSNP
rs184932784 525 dbSNP
rs1467433618 529 dbSNP
rs1427436159 531 dbSNP
rs1176460827 534 dbSNP
rs998869350 535 dbSNP
rs1020269576 561 dbSNP
rs1464426378 569 dbSNP
rs1026499237 574 dbSNP
rs573756240 581 dbSNP
rs978811178 585 dbSNP
rs531003966 591 dbSNP
rs1239245813 598 dbSNP
rs1200891775 605 dbSNP
rs925998849 614 dbSNP
rs1262086017 625 dbSNP
rs536408620 627 dbSNP
rs943414991 641 dbSNP
rs796283040 646 dbSNP
rs923231958 648 dbSNP
rs1377549826 660 dbSNP
rs552083132 674 dbSNP
rs1311246212 687 dbSNP
rs1450148898 694 dbSNP
rs1404227733 700 dbSNP
rs1388896449 708 dbSNP
rs1336264376 718 dbSNP
rs991252163 721 dbSNP
rs570698696 727 dbSNP
rs1156885807 729 dbSNP
rs892998671 730 dbSNP
rs771819651 734 dbSNP
rs113311223 744 dbSNP
rs918927650 745 dbSNP
rs1443124777 762 dbSNP
rs905781244 768 dbSNP
rs776907998 772 dbSNP
rs189829306 783 dbSNP
rs1198048265 785 dbSNP
rs1048767326 789 dbSNP
rs1489557570 801 dbSNP
rs537919085 808 dbSNP
rs1288022429 810 dbSNP
rs896789185 810 dbSNP
rs1431220464 814 dbSNP
rs1007335617 818 dbSNP
rs1172778733 824 dbSNP
rs151312608 839 dbSNP
rs993953816 849 dbSNP
rs1424198947 853 dbSNP
rs1039856921 858 dbSNP
rs952281786 864 dbSNP
rs1167841670 866 dbSNP
rs549875618 871 dbSNP
rs984923724 887 dbSNP
rs998438095 888 dbSNP
rs1020992549 895 dbSNP
rs903447742 896 dbSNP
rs1160925923 901 dbSNP
rs1423145620 906 dbSNP
rs545446097 915 dbSNP
rs1384930241 921 dbSNP
rs140546391 922 dbSNP
rs1032986172 923 dbSNP
rs1473607950 934 dbSNP
rs144047942 946 dbSNP
rs567889 947 dbSNP
rs867555391 948 dbSNP
rs368655022 949 dbSNP
rs971677146 950 dbSNP
rs988944790 953 dbSNP
rs1341628002 955 dbSNP
rs1218107471 966 dbSNP
rs561393899 971 dbSNP
rs1268601050 972 dbSNP
rs530272683 973 dbSNP
rs1399503558 979 dbSNP
rs1323581880 987 dbSNP
rs1222663973 988 dbSNP
rs914637377 1000 dbSNP
rs34215005 1004 dbSNP
rs1300593475 1005 dbSNP
rs146445217 1018 dbSNP
rs551723322 1028 dbSNP
rs1165978004 1029 dbSNP
rs984433707 1039 dbSNP
rs1166897737 1040 dbSNP
rs927080479 1040 dbSNP
rs1477414696 1053 dbSNP
rs938596460 1058 dbSNP
rs1196627164 1065 dbSNP
rs1490179143 1070 dbSNP
rs1247187638 1073 dbSNP
rs1057412025 1077 dbSNP
rs1435819396 1085 dbSNP
rs1271166799 1091 dbSNP
rs867617337 1101 dbSNP
rs560443248 1105 dbSNP
rs1318868650 1109 dbSNP
rs370171293 1113 dbSNP
rs896845485 1116 dbSNP
rs910246133 1120 dbSNP
rs140816182 1121 dbSNP
rs1347716742 1133 dbSNP
rs1423156691 1138 dbSNP
rs1040559377 1140 dbSNP
rs1300374712 1144 dbSNP
rs552421232 1146 dbSNP
rs1048183188 1150 dbSNP
rs1361742416 1154 dbSNP
rs1425294398 1167 dbSNP
rs1189216717 1170 dbSNP
rs1173691372 1172 dbSNP
rs1432055258 1176 dbSNP
rs1425819515 1190 dbSNP
rs773225208 1192 dbSNP
rs1192795100 1196 dbSNP
rs1400004414 1211 dbSNP
rs1479539900 1212 dbSNP
rs1268924766 1214 dbSNP
rs901335616 1215 dbSNP
rs888197735 1216 dbSNP
rs934112906 1219 dbSNP
rs1041895640 1220 dbSNP
rs1381498057 1223 dbSNP
rs1017741795 1236 dbSNP
rs565362064 1252 dbSNP
rs1311618759 1258 dbSNP
rs1302589675 1268 dbSNP
rs1221495673 1272 dbSNP
rs1371792226 1282 dbSNP
rs997748107 1286 dbSNP
rs1447935595 1287 dbSNP
rs1030992149 1289 dbSNP
rs1334235867 1290 dbSNP
rs528324506 1292 dbSNP
rs535067031 1301 dbSNP
rs1000422066 1315 dbSNP
rs914545162 1319 dbSNP
rs1218518953 1320 dbSNP
rs1032956466 1321 dbSNP
rs968801474 1329 dbSNP
rs894508571 1333 dbSNP
rs1179066512 1338 dbSNP
rs1286554540 1344 dbSNP
rs1013001066 1345 dbSNP
rs1024771987 1351 dbSNP
rs1441263637 1358 dbSNP
rs980156664 1376 dbSNP
rs971515016 1378 dbSNP
rs763049367 1381 dbSNP
rs1180266399 1383 dbSNP
rs766801457 1385 dbSNP
rs1483044508 1411 dbSNP
rs1487831828 1413 dbSNP
rs761790614 1417 dbSNP
rs1285885772 1419 dbSNP
rs1026172464 1423 dbSNP
rs1379507579 1431 dbSNP
rs938480103 1437 dbSNP
rs1057083995 1441 dbSNP
rs951925606 1479 dbSNP
rs144623058 1482 dbSNP
rs1180724862 1494 dbSNP
rs1359847030 1495 dbSNP
rs370678835 1496 dbSNP
rs1421291632 1498 dbSNP
rs943053106 1501 dbSNP
rs1186558281 1517 dbSNP
rs1423507722 1518 dbSNP
rs1441086072 1519 dbSNP
rs748754627 1519 dbSNP
rs572649402 1525 dbSNP
rs975774215 1532 dbSNP
rs1487323349 1546 dbSNP
rs1263124699 1550 dbSNP
rs11220176 1560 dbSNP
rs1006613036 1570 dbSNP
rs949295920 1596 dbSNP
rs1244492261 1597 dbSNP
rs1321991357 1603 dbSNP
rs1381387110 1608 dbSNP
rs1380040775 1618 dbSNP
rs550412202 1622 dbSNP
rs998090409 1636 dbSNP
rs1298268826 1637 dbSNP
rs1030458160 1638 dbSNP
rs770167851 1641 dbSNP
rs1361354186 1647 dbSNP
rs1042253999 1652 dbSNP
rs1448865039 1672 dbSNP
rs1369295606 1673 dbSNP
rs903384237 1678 dbSNP
rs1476886605 1679 dbSNP
rs1380667947 1684 dbSNP
rs567344136 1684 dbSNP
rs936244239 1686 dbSNP
rs138368921 1691 dbSNP
rs1489585943 1692 dbSNP
rs894732706 1696 dbSNP
rs1013300343 1701 dbSNP
rs1045744018 1704 dbSNP
rs907259154 1716 dbSNP
rs993621795 1717 dbSNP
rs568382140 1722 dbSNP
rs1026141402 1729 dbSNP
rs1242658815 1732 dbSNP
rs951896323 1733 dbSNP
rs553181272 1737 dbSNP
rs1266848410 1742 dbSNP
rs1352764643 1743 dbSNP
rs1316906472 1744 dbSNP
rs1278328639 1749 dbSNP
rs180885007 1751 dbSNP
rs1280681048 1752 dbSNP
rs1010459027 1753 dbSNP
rs1442876902 1758 dbSNP
rs1269270365 1763 dbSNP
rs1017491515 1770 dbSNP
rs964665283 1783 dbSNP
rs1387154327 1797 dbSNP
rs1392537814 1801 dbSNP
rs1208822841 1804 dbSNP
rs1296239259 1806 dbSNP
rs976124566 1808 dbSNP
rs968685585 1812 dbSNP
rs538949609 1817 dbSNP
rs1449106730 1819 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acGGAGACAGGUCGACACAUu 5'
            |:| ||| ::  |||||: 
Target 5' ugCUUGUGUGUGUGUGUGUGu 3'
 		1 - 21
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000534070.1 | 3UTR | UGCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000534070.1 | 3UTR | UGCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000534070.1 | 3UTR | UAUGCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000534070.1 | 3UTR | CUAUGCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000534070.1 | 3UTR | CUAUGCUUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000534070.1 | 3UTR | UGCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000534070.1 | 3UTR | UAUGCUUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000534070.1 | 3UTR | CUAUGCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000534070.1 | 3UTR | CUAUGCUUGUGUGUGUGUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000534070.1 | 3UTR | UGCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
126 hsa-miR-4672 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT060585 CCND1 cyclin D1 2 2
MIRT063968 ZNF678 zinc finger protein 678 2 2
MIRT078062 PCTP phosphatidylcholine transfer protein 2 2
MIRT084370 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT095611 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT096511 BRIX1 BRX1, biogenesis of ribosomes 2 4
MIRT121793 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT129470 CHEK1 checkpoint kinase 1 2 4
MIRT149009 PKN2 protein kinase N2 2 2
MIRT169592 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT177382 WAC WW domain containing adaptor with coiled-coil 2 4
MIRT214659 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 2
MIRT322680 BAG4 BCL2 associated athanogene 4 2 4
MIRT332490 CD81 CD81 molecule 2 6
MIRT338986 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT353814 PCBP1 poly(rC) binding protein 1 2 2
MIRT449368 ANTXR2 anthrax toxin receptor 2 2 2
MIRT459867 KIAA1191 KIAA1191 2 2
MIRT466272 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT467049 SRSF1 serine and arginine rich splicing factor 1 2 4
MIRT469925 PTPRJ protein tyrosine phosphatase, receptor type J 2 6
MIRT470361 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT471076 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472472 NAP1L1 nucleosome assembly protein 1 like 1 2 4
MIRT478137 DHX33 DEAH-box helicase 33 2 2
MIRT479414 CDKN1B cyclin dependent kinase inhibitor 1B 2 4
MIRT496523 ID2 inhibitor of DNA binding 2, HLH protein 2 2
MIRT510371 ZNF703 zinc finger protein 703 2 6
MIRT512861 TESK2 testis-specific kinase 2 2 2
MIRT512974 PPP1R14C protein phosphatase 1 regulatory inhibitor subunit 14C 2 4
MIRT513313 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT521882 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 4
MIRT522184 NR2C2 nuclear receptor subfamily 2 group C member 2 2 4
MIRT528381 TRAF3IP1 TRAF3 interacting protein 1 2 2
MIRT532412 ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2 2
MIRT533027 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533438 TRPC5 transient receptor potential cation channel subfamily C member 5 2 2
MIRT533919 TATDN2 TatD DNase domain containing 2 2 2
MIRT537568 ESYT2 extended synaptotagmin 2 2 2
MIRT538955 BMP2K BMP2 inducible kinase 2 2
MIRT539042 ATXN1L ataxin 1 like 2 4
MIRT539626 CD19 CD19 molecule 2 8
MIRT545720 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT546013 WDR26 WD repeat domain 26 2 4
MIRT549703 RBM23 RNA binding motif protein 23 2 4
MIRT551162 UBTF upstream binding transcription factor, RNA polymerase I 2 4
MIRT552078 MESDC2 mesoderm development LRP chaperone 2 4
MIRT552530 ZIC5 Zic family member 5 2 2
MIRT552670 YY1 YY1 transcription factor 2 4
MIRT554225 SLC24A2 solute carrier family 24 member 2 2 2
MIRT554356 SFXN5 sideroflexin 5 2 4
MIRT555279 PPTC7 PTC7 protein phosphatase homolog 2 4
MIRT555642 PHF13 PHD finger protein 13 2 2
MIRT558365 DIDO1 death inducer-obliterator 1 2 4
MIRT558630 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT559238 BEND4 BEN domain containing 4 2 2
MIRT559556 ARF6 ADP ribosylation factor 6 2 2
MIRT561686 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT562668 ANKRD40 ankyrin repeat domain 40 2 2
MIRT565689 SESN3 sestrin 3 2 2
MIRT566238 PTBP3 polypyrimidine tract binding protein 3 2 2
MIRT567699 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT573858 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT574156 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT575869 Kif5c kinesin family member 5C 2 3
MIRT576180 Muc15 mucin 15 2 5
MIRT606886 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 6
MIRT606908 ZBTB20 zinc finger and BTB domain containing 20 2 4
MIRT606914 MUC15 mucin 15, cell surface associated 2 7
MIRT607250 FAM216B family with sequence similarity 216 member B 2 4
MIRT607562 KIF5C kinesin family member 5C 2 3
MIRT609075 SMIM15 small integral membrane protein 15 2 6
MIRT609160 ZNF415 zinc finger protein 415 2 4
MIRT609360 ACOT2 acyl-CoA thioesterase 2 2 2
MIRT609799 ZDHHC17 zinc finger DHHC-type containing 17 2 2
MIRT610368 GRIPAP1 GRIP1 associated protein 1 2 2
MIRT611341 KIAA2018 upstream transcription factor family member 3 2 4
MIRT611732 PRSS23 protease, serine 23 2 4
MIRT611826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT611906 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT612377 TFCP2 transcription factor CP2 2 4
MIRT613482 LYRM7 LYR motif containing 7 2 2
MIRT613641 DUSP18 dual specificity phosphatase 18 2 4
MIRT613822 LANCL3 LanC like 3 2 4
MIRT613863 CBY3 chibby family member 3 2 4
MIRT613871 TMEM51 transmembrane protein 51 2 2
MIRT614688 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT615044 DCP2 decapping mRNA 2 2 2
MIRT616872 ARPC1B actin related protein 2/3 complex subunit 1B 2 4
MIRT617012 C16orf52 chromosome 16 open reading frame 52 2 2
MIRT618524 CCDC174 coiled-coil domain containing 174 2 2
MIRT621827 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT622108 SPRY4 sprouty RTK signaling antagonist 4 2 6
MIRT623111 NFATC2 nuclear factor of activated T-cells 2 2 2
MIRT626102 GNAI1 G protein subunit alpha i1 2 4
MIRT626416 ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2 2
MIRT627656 RTF1 RTF1 homolog, Paf1/RNA polymerase II complex component 2 2
MIRT628333 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT629334 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT630426 LMX1A LIM homeobox transcription factor 1 alpha 2 2
MIRT630707 GDNF glial cell derived neurotrophic factor 2 2
MIRT632568 POLQ DNA polymerase theta 2 2
MIRT632798 KIAA2022 neurite extension and migration factor 2 2
MIRT634125 ZDHHC21 zinc finger DHHC-type containing 21 2 4
MIRT634299 SP1 Sp1 transcription factor 2 2
MIRT634406 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT636827 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT638270 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT643060 CCDC149 coiled-coil domain containing 149 2 2
MIRT646160 SLC22A1 solute carrier family 22 member 1 2 2
MIRT648243 AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2 2
MIRT663402 SYT17 synaptotagmin 17 2 6
MIRT666042 STON2 stonin 2 2 2
MIRT670698 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT672337 TMEM79 transmembrane protein 79 2 4
MIRT672628 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT685229 F2RL1 F2R like trypsin receptor 1 2 2
MIRT693225 KIAA0907 KIAA0907 2 4
MIRT696142 RAB11FIP3 RAB11 family interacting protein 3 2 2
MIRT697908 TXNRD1 thioredoxin reductase 1 2 2
MIRT705315 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT712264 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT714080 ZNF532 zinc finger protein 532 2 2
MIRT715104 SORBS3 sorbin and SH3 domain containing 3 2 2
MIRT722237 RBM41 RNA binding motif protein 41 2 2
MIRT725113 SYNRG synergin gamma 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4672 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4672 Paclitaxel 36314 NSC125973 approved sensitive High Endometrial Serous Carcinoma cell line (USPC1)
hsa-miR-4672 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-mir-4672 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-4672 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4672 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4672 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (HCT116)
hsa-miR-4672 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4672 Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4672 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4672 Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-4672 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4672 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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