miRTarBase - #MIRT130186


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pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TXNIP   
Synonyms ARRDC6, EST01027, HHCPA78, THIF, VDUP1
Description thioredoxin interacting protein
Transcript NM_006472   
Expression
Putative miRNA Targets on TXNIP
3'UTR of TXNIP
(miRNA target sites are highlighted)		 
>TXNIP|NM_006472|3'UTR
   1 GCATGTGGAAGAAAAGAAGCAGCTTTACCTACTTGTTTCTTTTTGTCTCTCTTCCTGGACACTCACTTTTTCAGAGACTC
  81 AACAGTCTCTGCAATGGAGTGTGGGTCCACCTTAGCCTCTGACTTCCTAATGTAGGAGGTGGTCAGCAGGCAATCTCCTG
 161 GGCCTTAAAGGATGCGGACTCATCCTCAGCCAGCGCCCATGTTGTGATACAGGGGTGTTTGTTGGATGGGTTTAAAAATA
 241 ACTAGAAAAACTCAGGCCCATCCATTTTCTCAGATCTCCTTGAAAATTGAGGCCTTTTCGATAGTTTCGGGTCAGGTAAA
 321 AATGGCCTCCTGGCGTAAGCTTTTCAAGGTTTTTTGGAGGCTTTTTGTAAATTGTGATAGGAACTTTGGACCTTGAACTT
 401 ACGTATCATGTGGAGAAGAGCCAATTTAACAAACTAGGAAGATGAAAAGGGAAATTGTGGCCAAAACTTTGGGAAAAGGA
 481 GGTTCTTAAAATCAGTGTTTCCCCTTTGTGCACTTGTAGAAAAAAAAGAAAAACCTTCTAGAGCTGATTTGATGGACAAT
 561 GGAGAGAGCTTTCCCTGTGATTATAAAAAAGGAAGCTAGCTGCTCTACGGTCATCTTTGCTTAGAGTATACTTTAACCTG
 641 GCTTTTAAAGCAGTAGTAACTGCCCCACCAAAGGTCTTAAAAGCCATTTTTGGAGCCTATTGCACTGTGTTCTCCTACTG
 721 CAAATATTTTCATATGGGAGGATGGTTTTCTCTTCATGTAAGTCCTTGGAATTGATTCTAAGGTGATGTTCTTAGCACTT
 801 TAATTCCTGTCAAATTTTTTGTTCTCCCCTTCTGCCATCTTAAATGTAAGCTGAAACTGGTCTACTGTGTCTCTAGGGTT
 881 AAGCCAAAAGACAAAAAAAATTTTACTACTTTTGAGATTGCCCCAATGTACAGAATTATATAATTCTAACGCTTAAATCA
 961 TGTGAAAGGGTTGCTGCTGTCAGCCTTGCCCACTGTGACTTCAAACCCAAGGAGGAACTCTTGATCAAGATGCCCAACCC
1041 TGTGATCAGAACCTCCAAATACTGCCATGAGAAACTAGAGGGCAGGTCTTCATAAAAGCCCTTTGAACCCCCTTCCTGCC
1121 CTGTGTTAGGAGATAGGGATATTGGCCCCTCACTGCAGCTGCCAGCACTTGGTCAGTCACTCTCAGCCATAGCACTTTGT
1201 TCACTGTCCTGTGTCAGAGCACTGAGCTCCACCCTTTTCTGAGAGTTATTACAGCCAGAAAGTGTGGGCTGAAGATGGTT
1281 GGTTTCATGTTTTTGTATTATGTATCTTTTTGTATGGTAAAGACTATATTTTGTACTTAACCAGATATATTTTTACCCCA
1361 GATGGGGATATTCTTTGTAAAAAATGAAAATAAAGTTTTTTTAATGGAAAAAAAAATGTCTGTGAAAAAAAAAAAAAAAA
1441 AA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGUUCCCU-UAC-CGUCCCUUUa 5'
            | ||| | |||   ||||||| 
Target 5' aaCTAGGAAGATGAAAAGGGAAAt 3'
 432 - 455 152.00 -16.60
2 
miRNA  3' cgguUCCCUUACCGUCCCUUUa 5'
              ||| :||   ||||| | 
Target 5' tgttAGGAGAT---AGGGATAt 3'
 1124 - 1142 119.00 -10.60
3 
miRNA  3' cgguucccuuaCCGUCCCUUUa 5'
                     | |||| ||| 
Target 5' gatagtttcggGTCAGGTAAAa 3'
 300 - 321 115.00 -8.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31613608 26 COSMIC
COSN23013884 29 COSMIC
COSN30498918 54 COSMIC
COSN26345387 86 COSMIC
COSN31518012 87 COSMIC
COSN31544793 97 COSMIC
COSN13465511 153 COSMIC
COSN30168748 176 COSMIC
COSN22854620 212 COSMIC
COSN32082653 300 COSMIC
COSN20215506 357 COSMIC
COSN25793126 567 COSMIC
COSN31481257 609 COSMIC
COSN28929309 699 COSMIC
COSN31487417 731 COSMIC
COSN8319264 786 COSMIC
COSN7175900 895 COSMIC
COSN16130546 903 COSMIC
COSN31541469 950 COSMIC
COSN1404851 989 COSMIC
COSN31566757 1020 COSMIC
COSN30175504 1198 COSMIC
COSN28813251 1210 COSMIC
COSN31563457 1215 COSMIC
COSN17255712 1341 COSMIC
COSN8635856 1344 COSMIC
COSN16130598 1349 COSMIC
COSN8319265 1407 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs782324253 5 dbSNP
rs781922861 6 dbSNP
rs782164728 10 dbSNP
rs1042196726 11 dbSNP
rs1378865015 12 dbSNP
rs1238192616 14 dbSNP
rs1322340577 17 dbSNP
rs1223844421 20 dbSNP
rs782412186 20 dbSNP
rs782011331 23 dbSNP
rs1263824209 27 dbSNP
rs775233794 27 dbSNP
rs782126186 28 dbSNP
rs371598136 29 dbSNP
rs781829085 35 dbSNP
rs1179845309 39 dbSNP
rs762566229 45 dbSNP
rs187591491 47 dbSNP
rs782695925 49 dbSNP
rs1438233194 53 dbSNP
rs1176339594 56 dbSNP
rs1406774368 58 dbSNP
rs1405664156 61 dbSNP
rs371239177 62 dbSNP
rs763445640 66 dbSNP
rs191199120 68 dbSNP
rs1331993431 80 dbSNP
rs926556698 85 dbSNP
rs980068913 86 dbSNP
rs942069156 94 dbSNP
rs1380153984 102 dbSNP
rs1230279460 103 dbSNP
rs1310607527 110 dbSNP
rs1321232464 111 dbSNP
rs1199751130 115 dbSNP
rs1260570451 117 dbSNP
rs782040268 123 dbSNP
rs782156144 126 dbSNP
rs1198407308 128 dbSNP
rs1238455155 128 dbSNP
rs1472910620 134 dbSNP
rs1183259112 139 dbSNP
rs1410937390 144 dbSNP
rs1474596615 150 dbSNP
rs1171229323 157 dbSNP
rs1402347354 160 dbSNP
rs1464057644 161 dbSNP
rs1327900605 164 dbSNP
rs1359573889 167 dbSNP
rs983462122 171 dbSNP
rs1450421426 172 dbSNP
rs782151618 175 dbSNP
rs782730266 176 dbSNP
rs1219316893 182 dbSNP
rs751580661 189 dbSNP
rs1316562673 194 dbSNP
rs757127542 195 dbSNP
rs1279726855 196 dbSNP
rs782458723 199 dbSNP
rs1444522337 202 dbSNP
rs964973982 214 dbSNP
rs1018315568 215 dbSNP
rs1211711784 216 dbSNP
rs1235396722 239 dbSNP
rs1485173889 242 dbSNP
rs1193744753 246 dbSNP
rs1425196792 247 dbSNP
rs1000527363 251 dbSNP
rs782095422 264 dbSNP
rs782735059 269 dbSNP
rs1425527728 277 dbSNP
rs1415978448 281 dbSNP
rs1020648610 286 dbSNP
rs1375066981 292 dbSNP
rs182339054 293 dbSNP
rs896250928 294 dbSNP
rs1430590223 300 dbSNP
rs186992970 307 dbSNP
rs587669942 308 dbSNP
rs1280146264 309 dbSNP
rs1346661958 315 dbSNP
rs1216943737 318 dbSNP
rs1264644353 325 dbSNP
rs372245117 327 dbSNP
rs1247206460 328 dbSNP
rs1479008383 331 dbSNP
rs905099575 334 dbSNP
rs1394305473 335 dbSNP
rs1420489469 337 dbSNP
rs587633419 347 dbSNP
rs1358627658 351 dbSNP
rs1400205301 353 dbSNP
rs1324348440 357 dbSNP
rs587688547 366 dbSNP
rs880001759 372 dbSNP
rs1434993978 373 dbSNP
rs1303097894 380 dbSNP
rs1240339979 388 dbSNP
rs1378137080 388 dbSNP
rs1287737864 397 dbSNP
rs1348176239 402 dbSNP
rs7211 402 dbSNP
rs909194389 403 dbSNP
rs1252106635 405 dbSNP
rs139816793 405 dbSNP
rs983429530 408 dbSNP
rs1180677079 410 dbSNP
rs11537988 416 dbSNP
rs1378681121 420 dbSNP
rs1469875254 421 dbSNP
rs1163879673 425 dbSNP
rs1393031655 431 dbSNP
rs929395114 432 dbSNP
rs1325860264 434 dbSNP
rs1401411327 444 dbSNP
rs782760634 447 dbSNP
rs1449452453 451 dbSNP
rs1307615133 453 dbSNP
rs1333591721 454 dbSNP
rs923375748 455 dbSNP
rs587595014 458 dbSNP
rs144336702 461 dbSNP
rs587721930 462 dbSNP
rs979655270 466 dbSNP
rs1272484245 470 dbSNP
rs968300777 475 dbSNP
rs1458201715 478 dbSNP
rs782603988 483 dbSNP
rs1200297110 486 dbSNP
rs1248193527 499 dbSNP
rs1437439441 507 dbSNP
rs1188533701 516 dbSNP
rs1370225266 517 dbSNP
rs1020617601 518 dbSNP
rs1164375997 528 dbSNP
rs1471852789 528 dbSNP
rs1424966048 530 dbSNP
rs60016427 532 dbSNP
rs1329704935 535 dbSNP
rs1396260982 536 dbSNP
rs1390424829 537 dbSNP
rs1334409691 538 dbSNP
rs1341676501 540 dbSNP
rs1230906272 543 dbSNP
rs1009258927 547 dbSNP
rs960484146 549 dbSNP
rs1292204396 555 dbSNP
rs1318464304 556 dbSNP
rs1220448927 559 dbSNP
rs1249351897 560 dbSNP
rs1480204605 573 dbSNP
rs1201181041 578 dbSNP
rs17221751 580 dbSNP
rs1001967957 584 dbSNP
rs904984593 585 dbSNP
rs1491098482 591 dbSNP
rs1491237619 592 dbSNP
rs1479063432 600 dbSNP
rs1169206620 603 dbSNP
rs1372803185 604 dbSNP
rs1466890670 605 dbSNP
rs1038185991 606 dbSNP
rs1174735186 608 dbSNP
rs1005396171 609 dbSNP
rs887055645 610 dbSNP
rs1412581170 612 dbSNP
rs1311718841 614 dbSNP
rs1173796060 624 dbSNP
rs1293355589 625 dbSNP
rs1401723505 625 dbSNP
rs1306645745 627 dbSNP
rs1233700693 636 dbSNP
rs587625832 637 dbSNP
rs1210470225 640 dbSNP
rs1286782430 651 dbSNP
rs782317952 663 dbSNP
rs1489316693 676 dbSNP
rs929338953 678 dbSNP
rs923374357 680 dbSNP
rs1261621694 686 dbSNP
rs1434316789 688 dbSNP
rs1201416620 696 dbSNP
rs1393705612 697 dbSNP
rs1432427649 700 dbSNP
rs1172659571 707 dbSNP
rs1360531020 709 dbSNP
rs587680878 712 dbSNP
rs1361150127 715 dbSNP
rs1387331419 717 dbSNP
rs1303074471 720 dbSNP
rs755859477 720 dbSNP
rs1368560706 732 dbSNP
rs943471171 734 dbSNP
rs1287031216 735 dbSNP
rs1356195735 736 dbSNP
rs184403951 757 dbSNP
rs1260255804 760 dbSNP
rs1489078465 762 dbSNP
rs979622524 764 dbSNP
rs879951227 765 dbSNP
rs587616307 768 dbSNP
rs968269660 772 dbSNP
rs1380513567 778 dbSNP
rs914194992 783 dbSNP
rs1420548122 786 dbSNP
rs987815665 789 dbSNP
rs587697781 795 dbSNP
rs1327851862 797 dbSNP
rs1391945520 798 dbSNP
rs587738475 799 dbSNP
rs1439880342 802 dbSNP
rs188801165 813 dbSNP
rs1034694017 814 dbSNP
rs1222326818 816 dbSNP
rs1306316807 824 dbSNP
rs1002338477 826 dbSNP
rs1322437540 827 dbSNP
rs17215345 829 dbSNP
rs1247537919 846 dbSNP
rs1271839122 855 dbSNP
rs969178468 869 dbSNP
rs1199631976 871 dbSNP
rs1240471150 871 dbSNP
rs1481382993 872 dbSNP
rs1175151496 877 dbSNP
rs1406527116 881 dbSNP
rs1166547639 886 dbSNP
rs879991460 893 dbSNP
rs1491067549 894 dbSNP
rs17215338 897 dbSNP
rs1331759889 899 dbSNP
rs1016711766 900 dbSNP
rs1297825524 901 dbSNP
rs1356080896 901 dbSNP
rs1440237012 901 dbSNP
rs1379912358 908 dbSNP
rs1230086645 914 dbSNP
rs1005366474 922 dbSNP
rs887026030 924 dbSNP
rs1334743209 928 dbSNP
rs199827526 932 dbSNP
rs998124411 939 dbSNP
rs1201940875 940 dbSNP
rs1231944411 943 dbSNP
rs587637170 946 dbSNP
rs901803859 949 dbSNP
rs193055505 950 dbSNP
rs587754573 951 dbSNP
rs11537987 952 dbSNP
rs943433626 954 dbSNP
rs1408014581 959 dbSNP
rs1169551439 961 dbSNP
rs1359958985 962 dbSNP
rs1416911570 974 dbSNP
rs1311094732 979 dbSNP
rs1354936972 981 dbSNP
rs1401073154 982 dbSNP
rs910662203 984 dbSNP
rs1272447258 992 dbSNP
rs1360566475 1002 dbSNP
rs1214348658 1006 dbSNP
rs1279834666 1011 dbSNP
rs587707558 1017 dbSNP
rs1312385871 1018 dbSNP
rs1212604008 1026 dbSNP
rs1277515542 1027 dbSNP
rs778849135 1031 dbSNP
rs587631368 1033 dbSNP
rs946900640 1034 dbSNP
rs7212 1035 dbSNP
rs1474423371 1037 dbSNP
rs1185681179 1038 dbSNP
rs1425637740 1040 dbSNP
rs185869681 1044 dbSNP
rs4755 1045 dbSNP
rs11537984 1056 dbSNP
rs782111820 1062 dbSNP
rs747400980 1067 dbSNP
rs939637061 1072 dbSNP
rs1374865849 1074 dbSNP
rs782357128 1081 dbSNP
rs587663814 1082 dbSNP
rs1320449964 1086 dbSNP
rs1325170860 1087 dbSNP
rs587731065 1088 dbSNP
rs1275758715 1100 dbSNP
rs781954705 1102 dbSNP
rs1235949373 1103 dbSNP
rs148808239 1104 dbSNP
rs1300821227 1105 dbSNP
rs1346774785 1107 dbSNP
rs1216697503 1109 dbSNP
rs13340 1112 dbSNP
rs969092902 1115 dbSNP
rs75291601 1117 dbSNP
rs1445163633 1118 dbSNP
rs1215023304 1120 dbSNP
rs1247001755 1121 dbSNP
rs587742862 1123 dbSNP
rs1455432809 1128 dbSNP
rs1191582395 1133 dbSNP
rs587632424 1134 dbSNP
rs1440595578 1137 dbSNP
rs1025436781 1138 dbSNP
rs782067883 1143 dbSNP
rs1382907398 1146 dbSNP
rs1324782358 1149 dbSNP
rs1397061837 1152 dbSNP
rs1439140528 1153 dbSNP
rs901116218 1156 dbSNP
rs1369745291 1160 dbSNP
rs1239380532 1162 dbSNP
rs1280747961 1164 dbSNP
rs13203 1168 dbSNP
rs1223087601 1173 dbSNP
rs1469822683 1180 dbSNP
rs73004671 1181 dbSNP
rs1252203121 1182 dbSNP
rs1458344032 1184 dbSNP
rs1184283201 1185 dbSNP
rs1362065982 1186 dbSNP
rs1163966506 1192 dbSNP
rs1469702544 1192 dbSNP
rs889195041 1193 dbSNP
rs1043797905 1203 dbSNP
rs1460375002 1209 dbSNP
rs1325623390 1223 dbSNP
rs782809435 1224 dbSNP
rs1391541737 1226 dbSNP
rs946785983 1234 dbSNP
rs1060179 1239 dbSNP
rs1333683268 1246 dbSNP
rs1293420506 1248 dbSNP
rs1440836776 1248 dbSNP
rs782123605 1249 dbSNP
rs1231405845 1251 dbSNP
rs1272265404 1251 dbSNP
rs1339831652 1252 dbSNP
rs781886945 1256 dbSNP
rs1248667835 1268 dbSNP
rs939585610 1269 dbSNP
rs1188706047 1271 dbSNP
rs928262975 1274 dbSNP
rs1259759524 1279 dbSNP
rs1474484411 1285 dbSNP
rs980844449 1286 dbSNP
rs1164841981 1288 dbSNP
rs1424714665 1290 dbSNP
rs1463841426 1293 dbSNP
rs1166587935 1295 dbSNP
rs1393839142 1298 dbSNP
rs587744932 1301 dbSNP
rs17215352 1304 dbSNP
rs1356845442 1312 dbSNP
rs587697405 1314 dbSNP
rs1292610322 1315 dbSNP
rs951155166 1319 dbSNP
rs782761667 1326 dbSNP
rs1327009960 1328 dbSNP
rs1229331365 1330 dbSNP
rs1249443048 1334 dbSNP
rs587759329 1341 dbSNP
rs1211893044 1348 dbSNP
rs1484739763 1356 dbSNP
rs1282482732 1357 dbSNP
rs139537792 1359 dbSNP
rs1263042191 1360 dbSNP
rs587711312 1362 dbSNP
rs1430853212 1367 dbSNP
rs965670628 1373 dbSNP
rs1191461016 1379 dbSNP
rs1372896149 1381 dbSNP
rs1474856821 1384 dbSNP
rs1173878766 1385 dbSNP
rs1376677555 1390 dbSNP
rs1432309416 1391 dbSNP
rs1311815383 1395 dbSNP
rs1385539659 1402 dbSNP
rs1383900622 1403 dbSNP
rs1293116545 1404 dbSNP
rs1325670923 1411 dbSNP
rs1018223865 1413 dbSNP
rs1210215430 1417 dbSNP
rs1305882263 1417 dbSNP
rs143469330 1417 dbSNP
rs79787359 1417 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 10628.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgguucccuuaccguCCCUUUa 5'
                         |||||| 
Target 5' uguggccaaaacuuuGGGAAAa 3'
 		7 - 28
2 
miRNA  3' cgguucccuuaccgucCCUUua 5'
                          ||||  
Target 5' ----------------GGAAau 3'
 		1 - 6
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_006472 | 3UTR | AUCAUGUGGAGAAGAGCCAAUUUAACAAACUAGGAAGAUGAAAAGGGAAAUUGUGGCCAAAACUUUGGGAAAAGGAGGUUCUUAAAAUCAGUGUUUCCCCUUUGUGCACUUGUAGAAAAAAAAGAAAAACCUUCUAGAGCUGAUUUGAUGGACAAUGGAGAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903826
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID21_NS
Location of target site NM_006472 | 3UTR | AGGAAGAUGAAAAGGGAAAUUGUGGCCAAAACUUUGGGAAAAGGAGGUUCUUAAAAUCAGUGUUUCCCCUUUGUGCACUUGUAGAAAAAAAAGAAAAACCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000369317.4 | 3UTR | GGAAAUUGUGGCCAAAACUUUGGGAAAAGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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