miRTarBase - #MIRT132966


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pre-miRNA Information
pre-miRNA hsa-mir-4639   
Genomic Coordinates chr6: 16141556 - 16141624
Description Homo sapiens miR-4639 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4639-5p
Sequence 1| UUGCUAAGUAGGCUGAGAUUGA |22
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs754752699 4 dbSNP
rs765082627 5 dbSNP
rs931710265 19 dbSNP
rs1487272042 21 dbSNP
Putative Targets

Gene Information
Gene Symbol WNK1   
Synonyms HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65
Description WNK lysine deficient protein kinase 1
Transcript NM_014823   
Other Transcripts NM_001184985 , NM_018979 , NM_213655   
Expression
Putative miRNA Targets on WNK1
3'UTR of WNK1
(miRNA target sites are highlighted)		 
>WNK1|NM_014823|3'UTR
   1 ACCTAGAGACATTAACTGAATAGATCTGGGGGCAGGAGATGGAATGCTGAGGGGGTGGGTGGGGGTGGGAAGTAGCCTAT
  81 ATACTAACTACTAGTGCTGCATTTAACTGGTTATTTCTTGCCAGAGGGGAATGTTTTTAATACTGCATTGAGCCCTCAGA
 161 ATGGAGAGTCTCCCCCGCTCCAGTTATTGGAATGGGAGAGGAAGGAAAGAACAGCTTTTTTGTCAAGGGGCAGCTTCAGA
 241 CCATGCTTTCCTGTTTATCTATACTCAGTAATGAGGATGAGGGCTAGGAAAGTCTTGTTCATAAGGAAGCTGGAGAACTC
 321 AATGTAAAATCAAACCCATCTGTAATTTCGAGTGGGTGGAGCTCTTGCTTTTGGTACATGCCCTGAATCCCTCACTCCCT
 401 CAAGAATCCGAACCACAGGACAAAAACCACCTACTGGGCTCTCTCCTACCCTGCCCTCCTCCCTTTTTTTTACCCCTCTC
 481 TTTTTTATTTTTTCTTTGCTCTTTAGAACCCAGTGAAAAATACCAGGGTACTGGGGTGCAACTCTTTCTTATGATAGGTC
 561 ATTAGTGCTTTAAGCAAAAGATATTAGCAGCTTTGACTGCAGCATTAGCAATTAGGAAAAAAAAAAAATTAAGTTCCCTG
 641 CGGACATGTAACTTTGCCATCAGTTTTGATGTGGAAACACTGTGATATATAAAATGTTGTTGGACAACAGTAGTTTTAAG
 721 AGTAAAATATGAAACGTTTAAAAAGTTCCAAAAAAAGCTAGCTCTGTCCTTTACTTATTGAGACACTTTAACTTTTTCCT
 801 TTGTATTTCCATTGTATTAGATAAATAAATGTGAATGTAAAATTGTATAAATTACTGTACTTGAATACTTCTGTTTCCCA
 881 GTGTTGCTTGCTGGACATTTTAGTGCCTTGGACTTCTATTGCTTCTGCCATTAGCATCAACTTACCAGACCCCAGATCAA
 961 TAAAGGGCATGTGGAAGGAAATCGTAGGTCCATGTGACCCCAGCAGTCCAGCAGTGGTTATGCCAAAGGGAAATTGAAAA
1041 AGTATTTTTTTAAGTCATTCAACAACTTTGTCTAGAGCAGGTGTAAGATGAGTAGGGTGGGAAGTTAGGTTGGCATCAGT
1121 GGTTAAAAACAGAAAGTTCTGTTTCGGGAATAGTGAGGAGGGGGTGTTGTAACAAAATTGGACAACTTAAAAGAATGGTG
1201 TGTGCTGGGTGAAAGACAAAGACTAAAGAATGAGGAAACAAACGTGATGCCTGGCCAGTGACTGTCATATAAACCTTTCT
1281 TATTTGAGCTAGGCTTGAACAGACGTGACCTAGAAGAAACTGAACATAAAGAGAAGGGGGTGGGGGGCTAGTTTTCAAGT
1361 TGGGGAACCTGATAGTGAAAAGTCACAGATGGAGAAAATTGCTCTCAGAAAAACTGTTTGGATTGCTTTCCTCTTGTTGC
1441 ACATGTACCATGCATTTCTCAGCTTGGGGTACTACATTTTGTGGAAAGTTAATCTATCTATCTTTCCACATCTGAATTAA
1521 TCATTCTAGGAAAGAATACTTATTCCTACTCATTTCCTTTATGATGTCCAAATGGTTGCAGGATCATAATCTATTGTGCC
1601 ACCTTTATTTCTAGAAGTACAACTAATATGTTCACATTTTCAAATAAATAATACTCCCCGTAAGTAATAACTGCAACCAA
1681 TCAGTGTTATTCAGTGCTATGCCTCCTTGTAATGGGTAGTTATTAATTATTTTCAGAGCTTTCCGGAAATACTGTCCTAA
1761 CTGGCTATGTTTAGGATCTTTGTTATCTCTGAAGACAAAGAAAGAAGCTAGGACTCTTAATTTTGGGGTGCTTCTTGACT
1841 CTTAGTTGGGAAACTGAAAATATTTCCAACCTTTTACCCACGTCAATGGCATATTCTGGGAATCACCACCACCACCACCA
1921 CTACCACAGAAAGAGGCTGGAGGCTCCTGTACCCTGTTCATTCCTTAAGGGCCCTGCTTCCCTTAGTAAGTAAGTAAGTT
2001 GGTCTACGGCCCTAAATATGCAAATGAGAGCTGAAGGTTTTTAAAAGGTAGAAAGGAAAAGGGCAAGGGCTTCCACCCCT
2081 GCTTTAAAATGATTTATTTATTCTCTGCTTGTATTTCTTGTGGAGAGAGTAAGGATAGAACCAACAAGGGGCTGAGTAGC
2161 TGAGAAAGGGGCCACCCAAGAGTGAAACATACTTTATACCAGAGGAGCAGTGGAGCCTCATGCAGCACATTATCATTTGT
2241 TATTTGGGTTTAATAATAATTTTGACATCTTTTCACTCATACACAAAAAAAGTCAGAACTGGTGTTATTTACTGTTGATT
2321 TCATCCTCCTGTGTATGAAATAACAAGCCTAGAGGAATGAACTAGTGCTACTGAACTGTTTAAATTATTTTTGTGTTAAT
2401 AGTACACTTTGAGTATCTTTTTCCACATTAAAAACTTTCTGAATTATAAATGTTTTCCTTACATTATTTAACAATGTACA
2481 CTGTTAAAAATAAAAATAAAAATTCAAACTTTGGGGGTTTCTCAGCAGCCGTTAATTGTACATTTTGCACTAACTCTGGG
2561 TGTTGCGCTTCTTGTAAGATTGCGCTTTGTGCTTCAGTTTGTTACCTTTGTAGACTTATTTAATGAAACCATTCAAATAA
2641 ACCAAACTTGCTTTTGTTGAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aguuaGAGUCGGA-UGAAUCGUu 5'
               | | ||:|  |||||:| 
Target 5' aagggCCCTGCTTCCCTTAGTAa 3'
 1967 - 1989 133.00 -9.80
2 
miRNA  3' aguuagAGUCG--GAUGAAUCGUu 5'
                |:|||  | ||||| || 
Target 5' ctgccaTTAGCATCAACTTACCAg 3'
 925 - 948 126.00 -8.10
3 
miRNA  3' aguuaGA-GUCGGAUGAAUCGUu 5'
               || ||||    |||||| 
Target 5' tttgaCTGCAGCA---TTAGCAa 3'
 592 - 611 121.00 -12.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
880747 25 ClinVar
306666 48 ClinVar
1196627 51 ClinVar
880748 144 ClinVar
880749 149 ClinVar
306667 165 ClinVar
306668 177 ClinVar
882149 177 ClinVar
306669 278 ClinVar
882150 291 ClinVar
306670 379 ClinVar
306671 390 ClinVar
882151 410 ClinVar
306672 442 ClinVar
306673 464 ClinVar
306674 484 ClinVar
882396 532 ClinVar
882397 534 ClinVar
882398 559 ClinVar
882399 614 ClinVar
306675 617 ClinVar
306676 617 ClinVar
306677 643 ClinVar
306678 644 ClinVar
306679 653 ClinVar
882400 702 ClinVar
306680 759 ClinVar
306681 762 ClinVar
306682 767 ClinVar
306683 769 ClinVar
306684 1035 ClinVar
306685 1057 ClinVar
306686 1061 ClinVar
306687 1131 ClinVar
884108 1146 ClinVar
306688 1147 ClinVar
306689 1170 ClinVar
306690 1305 ClinVar
306691 1308 ClinVar
306692 1342 ClinVar
306693 1343 ClinVar
306694 1343 ClinVar
306695 1518 ClinVar
880810 1679 ClinVar
306696 1691 ClinVar
306697 1722 ClinVar
306698 1745 ClinVar
306699 1765 ClinVar
306700 1870 ClinVar
306701 1904 ClinVar
306702 1904 ClinVar
306708 1932 ClinVar
306709 1938 ClinVar
306710 1972 ClinVar
882457 1983 ClinVar
306711 1987 ClinVar
306712 1991 ClinVar
882458 2008 ClinVar
306713 2091 ClinVar
882459 2135 ClinVar
306715 2190 ClinVar
884159 2237 ClinVar
306716 2245 ClinVar
306723 2309 ClinVar
306726 2377 ClinVar
306729 2414 ClinVar
306731 2475 ClinVar
306736 2563 ClinVar
306737 2576 ClinVar
306738 2584 ClinVar
306741 2614 ClinVar
COSN30110238 7 COSMIC
COSN19656669 51 COSMIC
COSN28879203 56 COSMIC
COSN27217130 629 COSMIC
COSN8691667 1298 COSMIC
COSN20109037 1499 COSMIC
COSN8691678 1621 COSMIC
COSN5314253 1716 COSMIC
COSN6612727 1726 COSMIC
COSN1140827 1876 COSMIC
COSN28456903 1905 COSMIC
COSN10096170 1994 COSMIC
COSN17781764 2318 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751771724 1 dbSNP
rs373237393 3 dbSNP
rs1240314353 6 dbSNP
rs1391721352 11 dbSNP
rs374769683 18 dbSNP
rs1438831099 20 dbSNP
rs367692602 25 dbSNP
rs756197223 26 dbSNP
rs1180470779 27 dbSNP
rs1420294964 28 dbSNP
rs1430587977 29 dbSNP
rs1161868059 31 dbSNP
rs1365397287 32 dbSNP
rs778456158 33 dbSNP
rs1035174417 36 dbSNP
rs774547211 39 dbSNP
rs1430627157 41 dbSNP
rs754350903 46 dbSNP
rs556130311 48 dbSNP
rs1243384231 50 dbSNP
rs1215376826 51 dbSNP
rs1292018946 51 dbSNP
rs774719267 51 dbSNP
rs1313957130 52 dbSNP
rs192925947 53 dbSNP
rs1288516853 54 dbSNP
rs1224839823 55 dbSNP
rs1367502389 57 dbSNP
rs148449932 59 dbSNP
rs1166995781 61 dbSNP
rs1438666559 61 dbSNP
rs1346444103 63 dbSNP
rs184306404 66 dbSNP
rs1174935415 67 dbSNP
rs897445100 68 dbSNP
rs762234459 76 dbSNP
rs1358401565 80 dbSNP
rs1160178226 83 dbSNP
rs1401278859 83 dbSNP
rs1400749179 88 dbSNP
rs1319793389 94 dbSNP
rs1424331910 125 dbSNP
rs930226600 128 dbSNP
rs1048903550 130 dbSNP
rs960409528 144 dbSNP
rs1487070672 146 dbSNP
rs987808519 149 dbSNP
rs1001918014 154 dbSNP
rs767710474 165 dbSNP
rs1347200667 171 dbSNP
rs1221559079 172 dbSNP
rs1324409467 175 dbSNP
rs528692788 177 dbSNP
rs1282538043 178 dbSNP
rs1329821317 181 dbSNP
rs1290450142 183 dbSNP
rs1013460786 188 dbSNP
rs1205788782 189 dbSNP
rs1173904620 191 dbSNP
rs1024813582 196 dbSNP
rs116626385 199 dbSNP
rs1429397931 209 dbSNP
rs967051374 214 dbSNP
rs999435536 217 dbSNP
rs562090430 225 dbSNP
rs1187523002 233 dbSNP
rs1483141875 234 dbSNP
rs117827410 236 dbSNP
rs910407875 242 dbSNP
rs1236049713 250 dbSNP
rs1212870164 258 dbSNP
rs1462115228 262 dbSNP
rs1032643487 263 dbSNP
rs187106160 276 dbSNP
rs80258895 278 dbSNP
rs750956260 282 dbSNP
rs1227914496 285 dbSNP
rs1378176114 289 dbSNP
rs761039206 292 dbSNP
rs923367150 295 dbSNP
rs1197760956 297 dbSNP
rs191609079 301 dbSNP
rs1330144880 302 dbSNP
rs183849144 304 dbSNP
rs1374247512 318 dbSNP
rs910977336 319 dbSNP
rs1422813282 323 dbSNP
rs1047741417 350 dbSNP
rs965090082 351 dbSNP
rs886048804 379 dbSNP
rs1399719011 385 dbSNP
rs886048805 390 dbSNP
rs887750826 395 dbSNP
rs1006457805 396 dbSNP
rs11554420 400 dbSNP
rs367847712 410 dbSNP
rs918743065 415 dbSNP
rs930106957 418 dbSNP
rs1221127036 419 dbSNP
rs866618231 420 dbSNP
rs1320127752 423 dbSNP
rs1045025748 428 dbSNP
rs1310397329 442 dbSNP
rs753439066 442 dbSNP
rs1383501866 451 dbSNP
rs1402840429 460 dbSNP
rs1282475446 461 dbSNP
rs534020827 462 dbSNP
rs1241101800 464 dbSNP
rs886048806 464 dbSNP
rs937368769 465 dbSNP
rs1281313258 466 dbSNP
rs189247899 472 dbSNP
rs895944191 476 dbSNP
rs567523171 478 dbSNP
rs1046290052 481 dbSNP
rs1223340396 481 dbSNP
rs776498995 483 dbSNP
rs144238789 484 dbSNP
rs886048807 484 dbSNP
rs902354808 484 dbSNP
rs1009291787 485 dbSNP
rs1251407281 485 dbSNP
rs6878 495 dbSNP
rs199802782 501 dbSNP
rs1032262748 510 dbSNP
rs967686214 513 dbSNP
rs958160351 523 dbSNP
rs1267433974 524 dbSNP
rs147592854 531 dbSNP
rs192527684 532 dbSNP
rs965129972 533 dbSNP
rs1274582557 534 dbSNP
rs1361513024 537 dbSNP
rs1385707844 540 dbSNP
rs1304612745 542 dbSNP
rs1364814542 542 dbSNP
rs1424827093 545 dbSNP
rs964626186 545 dbSNP
rs1469162120 549 dbSNP
rs1157217796 553 dbSNP
rs1455866257 557 dbSNP
rs1364847769 559 dbSNP
rs554033758 575 dbSNP
rs1431534689 576 dbSNP
rs923087195 580 dbSNP
rs777074975 582 dbSNP
rs1386705032 602 dbSNP
rs1422426709 603 dbSNP
rs929406310 605 dbSNP
rs918308760 612 dbSNP
rs1047791734 614 dbSNP
rs1203161552 615 dbSNP
rs1262282960 615 dbSNP
rs1396985179 616 dbSNP
rs1261260391 617 dbSNP
rs1349228924 617 dbSNP
rs886048808 617 dbSNP
rs886048809 617 dbSNP
rs951581618 617 dbSNP
rs1284578911 618 dbSNP
rs984663890 626 dbSNP
rs185587745 628 dbSNP
rs937588485 642 dbSNP
rs886048810 643 dbSNP
rs886048811 644 dbSNP
rs560549119 653 dbSNP
rs886048812 653 dbSNP
rs1464926740 655 dbSNP
rs1315888772 657 dbSNP
rs950001778 658 dbSNP
rs1477658678 670 dbSNP
rs1421721853 672 dbSNP
rs1195529269 676 dbSNP
rs1041840023 694 dbSNP
rs1262080740 704 dbSNP
rs1291453056 705 dbSNP
rs903226716 711 dbSNP
rs1459913304 725 dbSNP
rs942024797 731 dbSNP
rs1340532180 732 dbSNP
rs1316973272 736 dbSNP
rs544759756 737 dbSNP
rs878962379 749 dbSNP
rs1327395828 750 dbSNP
rs1333859003 752 dbSNP
rs1197980652 756 dbSNP
rs75767195 759 dbSNP
rs1054019129 762 dbSNP
rs886048813 762 dbSNP
rs886048814 767 dbSNP
rs1183656697 769 dbSNP
rs886048815 769 dbSNP
rs906110474 770 dbSNP
rs1003102832 775 dbSNP
rs1244460248 778 dbSNP
rs573095233 779 dbSNP
rs893762328 781 dbSNP
rs1442746825 787 dbSNP
rs778766378 787 dbSNP
rs1018120341 789 dbSNP
rs900865521 790 dbSNP
rs997767961 804 dbSNP
rs1197204004 808 dbSNP
rs1025402977 812 dbSNP
rs1166003797 821 dbSNP
rs752390977 824 dbSNP
rs951200514 825 dbSNP
rs1385691624 831 dbSNP
rs1316363344 834 dbSNP
rs984346438 835 dbSNP
rs1009340931 843 dbSNP
rs1337393174 846 dbSNP
rs1162495949 857 dbSNP
rs1020712297 883 dbSNP
rs1385128234 887 dbSNP
rs917479872 895 dbSNP
rs967738672 903 dbSNP
rs977384938 905 dbSNP
rs1312256074 914 dbSNP
rs1000949705 918 dbSNP
rs1017233980 919 dbSNP
rs1438109486 931 dbSNP
rs540380416 933 dbSNP
rs924753861 935 dbSNP
rs758215125 946 dbSNP
rs965007090 952 dbSNP
rs1362085280 955 dbSNP
rs1292904733 956 dbSNP
rs879222077 961 dbSNP
rs1371775048 963 dbSNP
rs1281415298 966 dbSNP
rs190594320 970 dbSNP
rs529525687 974 dbSNP
rs777370872 984 dbSNP
rs544909920 985 dbSNP
rs34910358 988 dbSNP
rs1204893809 989 dbSNP
rs1433955655 991 dbSNP
rs893644268 995 dbSNP
rs1405695534 1009 dbSNP
rs983540688 1020 dbSNP
rs942515056 1021 dbSNP
rs149561425 1034 dbSNP
rs112549606 1035 dbSNP
rs1459571276 1045 dbSNP
rs901064544 1045 dbSNP
rs1182484292 1051 dbSNP
rs1196870120 1053 dbSNP
rs765836409 1057 dbSNP
rs980527422 1059 dbSNP
rs533399537 1061 dbSNP
rs181746260 1078 dbSNP
rs531578842 1081 dbSNP
rs1286973261 1083 dbSNP
rs551896719 1087 dbSNP
rs1057376800 1093 dbSNP
rs892006800 1094 dbSNP
rs1005703070 1097 dbSNP
rs946188237 1098 dbSNP
rs781089916 1101 dbSNP
rs1303604527 1105 dbSNP
rs572694428 1118 dbSNP
rs991614933 1120 dbSNP
rs1320207053 1123 dbSNP
rs903604309 1130 dbSNP
rs546217405 1131 dbSNP
rs886048816 1131 dbSNP
rs1423920750 1137 dbSNP
rs749431956 1142 dbSNP
rs186013009 1146 dbSNP
rs78913352 1147 dbSNP
rs997866475 1151 dbSNP
rs1485100651 1152 dbSNP
rs1384152672 1159 dbSNP
rs1405806738 1162 dbSNP
rs1217160323 1163 dbSNP
rs1293799776 1164 dbSNP
rs549160638 1170 dbSNP
rs758553014 1177 dbSNP
rs1030203262 1179 dbSNP
rs1340317426 1189 dbSNP
rs957366269 1190 dbSNP
rs1212955215 1198 dbSNP
rs1359637522 1200 dbSNP
rs764218312 1224 dbSNP
rs1224558590 1225 dbSNP
rs990657927 1235 dbSNP
rs950588709 1236 dbSNP
rs910599081 1237 dbSNP
rs1470678303 1239 dbSNP
rs983249882 1240 dbSNP
rs188814667 1244 dbSNP
rs933894210 1245 dbSNP
rs963807461 1250 dbSNP
rs980197310 1262 dbSNP
rs1472795924 1263 dbSNP
rs1241819548 1264 dbSNP
rs1206057451 1267 dbSNP
rs1461827782 1270 dbSNP
rs1046757460 1276 dbSNP
rs1202760585 1283 dbSNP
rs1309455733 1284 dbSNP
rs927309770 1287 dbSNP
rs1005192058 1290 dbSNP
rs938693450 1293 dbSNP
rs993113617 1301 dbSNP
rs766319091 1305 dbSNP
rs1024474459 1306 dbSNP
rs181330586 1306 dbSNP
rs1201370324 1307 dbSNP
rs547941922 1308 dbSNP
rs1402546251 1312 dbSNP
rs1480104511 1312 dbSNP
rs946242462 1329 dbSNP
rs1424433210 1336 dbSNP
rs1433862362 1337 dbSNP
rs971663000 1338 dbSNP
rs1043266848 1341 dbSNP
rs1445746438 1341 dbSNP
rs1175554781 1342 dbSNP
rs1364466577 1342 dbSNP
rs886048817 1342 dbSNP
rs77954451 1343 dbSNP
rs1289264185 1348 dbSNP
rs538672136 1348 dbSNP
rs1248142086 1351 dbSNP
rs1287307108 1353 dbSNP
rs1360026017 1363 dbSNP
rs936447512 1368 dbSNP
rs1246081383 1374 dbSNP
rs1360173562 1375 dbSNP
rs910671290 1376 dbSNP
rs1298397011 1378 dbSNP
rs1305401071 1378 dbSNP
rs964764320 1378 dbSNP
rs975242058 1383 dbSNP
rs755125727 1390 dbSNP
rs1165832311 1402 dbSNP
rs1344111257 1407 dbSNP
rs185595322 1411 dbSNP
rs922428916 1412 dbSNP
rs1157487846 1415 dbSNP
rs933812968 1427 dbSNP
rs1251287696 1428 dbSNP
rs1198996795 1433 dbSNP
rs1489914795 1434 dbSNP
rs1266558228 1437 dbSNP
rs571767845 1445 dbSNP
rs1219161487 1452 dbSNP
rs1289723105 1455 dbSNP
rs1038765291 1463 dbSNP
rs900207497 1464 dbSNP
rs1260086289 1468 dbSNP
rs72652208 1473 dbSNP
rs1047438792 1479 dbSNP
rs997132009 1488 dbSNP
rs908413636 1491 dbSNP
rs1222572207 1492 dbSNP
rs1307020711 1492 dbSNP
rs781379950 1492 dbSNP
rs941030396 1493 dbSNP
rs1305403470 1495 dbSNP
rs3072752 1496 dbSNP
rs33915619 1497 dbSNP
rs886375016 1497 dbSNP
rs1012652573 1498 dbSNP
rs72516321 1498 dbSNP
rs397783428 1499 dbSNP
rs72652209 1499 dbSNP
rs907389051 1500 dbSNP
rs755837296 1501 dbSNP
rs1016538325 1510 dbSNP
rs1488080742 1515 dbSNP
rs1451968621 1517 dbSNP
rs535956701 1518 dbSNP
rs869225909 1518 dbSNP
rs1410132712 1519 dbSNP
rs780624528 1540 dbSNP
rs1486792057 1544 dbSNP
rs1268290039 1545 dbSNP
rs980633389 1547 dbSNP
rs957637144 1549 dbSNP
rs1420922782 1550 dbSNP
rs1157092325 1552 dbSNP
rs1223705438 1555 dbSNP
rs1034430817 1566 dbSNP
rs1379899579 1583 dbSNP
rs1326235148 1584 dbSNP
rs761069376 1589 dbSNP
rs992832371 1594 dbSNP
rs1386308181 1597 dbSNP
rs1012032459 1600 dbSNP
rs913212959 1605 dbSNP
rs1243028319 1608 dbSNP
rs1425549006 1609 dbSNP
rs1468308650 1619 dbSNP
rs1408304908 1621 dbSNP
rs551298334 1621 dbSNP
rs1475178583 1626 dbSNP
rs1372333197 1629 dbSNP
rs1190715586 1630 dbSNP
rs1430301095 1631 dbSNP
rs370180921 1635 dbSNP
rs964797001 1637 dbSNP
rs1459615397 1645 dbSNP
rs1264411365 1656 dbSNP
rs555510350 1657 dbSNP
rs1186863363 1660 dbSNP
rs574206560 1660 dbSNP
rs879731863 1668 dbSNP
rs1230053163 1669 dbSNP
rs1327331287 1677 dbSNP
rs549784205 1678 dbSNP
rs72652265 1678 dbSNP
rs955384629 1678 dbSNP
rs926140512 1681 dbSNP
rs544563937 1684 dbSNP
rs777271019 1689 dbSNP
rs886048818 1691 dbSNP
rs1299224383 1693 dbSNP
rs908487265 1694 dbSNP
rs1389172244 1697 dbSNP
rs1394592729 1706 dbSNP
rs777263403 1714 dbSNP
rs1359640755 1718 dbSNP
rs941284387 1720 dbSNP
rs561811313 1722 dbSNP
rs749132930 1722 dbSNP
rs886048819 1722 dbSNP
rs563236652 1723 dbSNP
rs921711500 1724 dbSNP
rs1187636431 1726 dbSNP
rs1436921302 1730 dbSNP
rs1445240506 1736 dbSNP
rs1045510914 1740 dbSNP
rs933046144 1741 dbSNP
rs886048820 1745 dbSNP
rs886091887 1746 dbSNP
rs764771382 1754 dbSNP
rs1320864408 1757 dbSNP
rs893403790 1758 dbSNP
rs147760490 1765 dbSNP
rs1284920565 1766 dbSNP
rs757936706 1768 dbSNP
rs1441586132 1773 dbSNP
rs1234524319 1777 dbSNP
rs1017785910 1797 dbSNP
rs1331169774 1797 dbSNP
rs1370991946 1797 dbSNP
rs545378279 1806 dbSNP
rs1422741729 1807 dbSNP
rs1479648132 1809 dbSNP
rs1163710217 1810 dbSNP
rs900531273 1813 dbSNP
rs1230636285 1818 dbSNP
rs1176792475 1835 dbSNP
rs1237645169 1836 dbSNP
rs1268673221 1841 dbSNP
rs72652266 1842 dbSNP
rs1490927366 1861 dbSNP
rs1291228331 1867 dbSNP
rs886048821 1870 dbSNP
rs1030378354 1881 dbSNP
rs560493377 1882 dbSNP
rs763975922 1883 dbSNP
rs1229286869 1887 dbSNP
rs142664245 1893 dbSNP
rs1383672377 1896 dbSNP
rs1405108536 1897 dbSNP
rs1302376151 1901 dbSNP
rs983058641 1901 dbSNP
rs1171642622 1903 dbSNP
rs1399990845 1904 dbSNP
rs1405220967 1904 dbSNP
rs778502996 1904 dbSNP
rs886048822 1904 dbSNP
rs886048823 1904 dbSNP
rs973998506 1904 dbSNP
rs915792726 1905 dbSNP
rs1472751237 1907 dbSNP
rs948376055 1909 dbSNP
rs1196756004 1912 dbSNP
rs1481642947 1916 dbSNP
rs1247611255 1919 dbSNP
rs981097333 1920 dbSNP
rs1356774509 1921 dbSNP
rs527753705 1923 dbSNP
rs1330015122 1925 dbSNP
rs1034557297 1930 dbSNP
rs529382173 1932 dbSNP
rs886048824 1932 dbSNP
rs1454206830 1935 dbSNP
rs1312418650 1936 dbSNP
rs2023943 1938 dbSNP
rs1225537702 1940 dbSNP
rs1214923123 1942 dbSNP
rs1053726663 1946 dbSNP
rs560909082 1947 dbSNP
rs893319591 1951 dbSNP
rs1343358660 1961 dbSNP
rs1274869585 1963 dbSNP
rs1305627701 1966 dbSNP
rs548345320 1967 dbSNP
rs1322036313 1971 dbSNP
rs536971299 1972 dbSNP
rs1039262375 1977 dbSNP
rs72652267 1985 dbSNP
rs781110305 1985 dbSNP
rs900726457 1985 dbSNP
rs754529970 1986 dbSNP
rs2023944 1987 dbSNP
rs747823233 1989 dbSNP
rs1189698604 1991 dbSNP
rs886048825 1991 dbSNP
rs1460951150 1992 dbSNP
rs1261282362 1995 dbSNP
rs1205867572 1999 dbSNP
rs1472625953 2003 dbSNP
rs1312959160 2006 dbSNP
rs150269723 2008 dbSNP
rs926220833 2009 dbSNP
rs1359532606 2011 dbSNP
rs1004954777 2015 dbSNP
rs1016732706 2020 dbSNP
rs1381473436 2025 dbSNP
rs1477107093 2030 dbSNP
rs1334086883 2033 dbSNP
rs1467321062 2045 dbSNP
rs1359369445 2048 dbSNP
rs1170627023 2070 dbSNP
rs962592479 2079 dbSNP
rs886048826 2091 dbSNP
rs1444538541 2092 dbSNP
rs995305430 2092 dbSNP
rs1241399567 2093 dbSNP
rs1185489609 2094 dbSNP
rs1483733308 2096 dbSNP
rs775274871 2096 dbSNP
rs1345541979 2101 dbSNP
rs1232531929 2104 dbSNP
rs1202648562 2111 dbSNP
rs1022922613 2112 dbSNP
rs1276491050 2119 dbSNP
rs1229109829 2123 dbSNP
rs1358638823 2124 dbSNP
rs367854726 2125 dbSNP
rs1312353344 2128 dbSNP
rs576482299 2131 dbSNP
rs964611590 2138 dbSNP
rs571470077 2139 dbSNP
rs922731797 2142 dbSNP
rs1431019263 2146 dbSNP
rs969962198 2148 dbSNP
rs933098346 2152 dbSNP
rs745742970 2161 dbSNP
rs1308984017 2163 dbSNP
rs1424655690 2171 dbSNP
rs1383909312 2173 dbSNP
rs1167451353 2185 dbSNP
rs1424476507 2186 dbSNP
rs568163399 2190 dbSNP
rs886048828 2190 dbSNP
rs1051440806 2193 dbSNP
rs1481725179 2213 dbSNP
rs928309034 2217 dbSNP
rs538555627 2219 dbSNP
rs955871377 2230 dbSNP
rs1490109135 2231 dbSNP
rs988599128 2232 dbSNP
rs11571500 2237 dbSNP
rs1305646710 2237 dbSNP
rs1221754554 2240 dbSNP
rs1351940665 2240 dbSNP
rs1039167656 2243 dbSNP
rs565358026 2245 dbSNP
rs1295827787 2246 dbSNP
rs545392160 2247 dbSNP
rs1037738632 2248 dbSNP
rs933554486 2249 dbSNP
rs1216817908 2251 dbSNP
rs1456527392 2251 dbSNP
rs11571499 2266 dbSNP
rs548847463 2267 dbSNP
rs566958070 2270 dbSNP
rs1005268165 2285 dbSNP
rs1318044032 2285 dbSNP
rs886453905 2285 dbSNP
rs1001833022 2287 dbSNP
rs1193476913 2290 dbSNP
rs1211615553 2290 dbSNP
rs1488748477 2293 dbSNP
rs1259701939 2299 dbSNP
rs1037799739 2305 dbSNP
rs1213015297 2305 dbSNP
rs1481710884 2308 dbSNP
rs1060499 2309 dbSNP
rs995380278 2314 dbSNP
rs190805853 2319 dbSNP
rs1423892937 2323 dbSNP
rs895639676 2324 dbSNP
rs1014372001 2328 dbSNP
rs1020380309 2332 dbSNP
rs1361857507 2334 dbSNP
rs969993488 2334 dbSNP
rs1287573238 2341 dbSNP
rs1319854033 2342 dbSNP
rs1458891946 2342 dbSNP
rs11833 2344 dbSNP
rs1343111396 2356 dbSNP
rs1389420960 2356 dbSNP
rs967407115 2366 dbSNP
rs1399161251 2377 dbSNP
rs879113303 2380 dbSNP
rs1491408257 2381 dbSNP
rs886048830 2382 dbSNP
rs1035995393 2387 dbSNP
rs1303599227 2392 dbSNP
rs1260969778 2394 dbSNP
rs1186519260 2397 dbSNP
rs955738144 2398 dbSNP
rs778916345 2401 dbSNP
rs1202687213 2405 dbSNP
rs1320972374 2410 dbSNP
rs533525466 2410 dbSNP
rs1234437305 2411 dbSNP
rs11571497 2414 dbSNP
rs1294101141 2418 dbSNP
rs914359318 2421 dbSNP
rs1033388205 2436 dbSNP
rs968435436 2439 dbSNP
rs3179393 2440 dbSNP
rs1450813916 2449 dbSNP
rs964337848 2451 dbSNP
rs974904281 2451 dbSNP
rs1173316969 2455 dbSNP
rs1466361710 2456 dbSNP
rs1376393457 2457 dbSNP
rs976054893 2459 dbSNP
rs1372245575 2464 dbSNP
rs1286600306 2470 dbSNP
rs1248183013 2473 dbSNP
rs1487462991 2473 dbSNP
rs1182434836 2474 dbSNP
rs1216267530 2474 dbSNP
rs11571496 2475 dbSNP
rs1257843816 2481 dbSNP
rs1200638365 2484 dbSNP
rs1339165641 2484 dbSNP
rs1272901304 2485 dbSNP
rs1231306737 2487 dbSNP
rs577669094 2487 dbSNP
rs1490972284 2489 dbSNP
rs1343492847 2490 dbSNP
rs538685828 2493 dbSNP
rs538479783 2498 dbSNP
rs1314528999 2504 dbSNP
rs1243884107 2506 dbSNP
rs933461563 2507 dbSNP
rs1246685867 2508 dbSNP
rs1052041134 2510 dbSNP
rs1305953158 2510 dbSNP
rs908080672 2510 dbSNP
rs773789631 2517 dbSNP
rs955533673 2518 dbSNP
rs182657421 2526 dbSNP
rs556484003 2530 dbSNP
rs940405065 2531 dbSNP
rs1418729705 2532 dbSNP
rs11571495 2549 dbSNP
rs11571494 2552 dbSNP
rs1384963290 2553 dbSNP
rs973109329 2558 dbSNP
rs1291696362 2560 dbSNP
rs1045146315 2561 dbSNP
rs773462361 2563 dbSNP
rs937303457 2565 dbSNP
rs1056099792 2567 dbSNP
rs1443000111 2568 dbSNP
rs895691904 2571 dbSNP
rs1281361393 2572 dbSNP
rs1351690976 2576 dbSNP
rs886048832 2576 dbSNP
rs1239731092 2577 dbSNP
rs558083402 2581 dbSNP
rs949859453 2582 dbSNP
rs1041540397 2583 dbSNP
rs11571493 2584 dbSNP
rs1000667072 2593 dbSNP
rs1163324158 2598 dbSNP
rs1469358733 2601 dbSNP
rs1409321996 2605 dbSNP
rs1208470786 2606 dbSNP
rs1033041598 2609 dbSNP
rs376351532 2614 dbSNP
rs886048833 2614 dbSNP
rs1471227365 2615 dbSNP
rs1473140758 2631 dbSNP
rs1268562594 2635 dbSNP
rs774385896 2635 dbSNP
rs540423647 2638 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000315939.6 | 3UTR | AUUAGGAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000315939.6 | 3UTR | CAAUUAGGAAAAAAAAAAAAUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000315939.6 | 3UTR | AAUUAGGAAAAAAAAAAAAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000315939.6 | 3UTR | GCAAUUAGGAAAAAAAAAAAAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-4639-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT063335 ETNK1 ethanolamine kinase 1 2 2
MIRT077667 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT080431 NARS asparaginyl-tRNA synthetase 2 2
MIRT130192 TXNIP thioredoxin interacting protein 2 2
MIRT132966 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT138729 MPP5 membrane palmitoylated protein 5 2 2
MIRT152230 ZNF460 zinc finger protein 460 2 2
MIRT197361 ZNF652 zinc finger protein 652 2 2
MIRT282675 SYNM synemin 2 2
MIRT292617 CEBPG CCAAT/enhancer binding protein gamma 2 6
MIRT314026 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 2
MIRT325195 PSAT1 phosphoserine aminotransferase 1 2 2
MIRT329855 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT336755 ZNF678 zinc finger protein 678 2 2
MIRT445350 ARSK arylsulfatase family member K 2 2
MIRT456953 EDARADD EDAR associated death domain 2 6
MIRT467718 SLC38A1 solute carrier family 38 member 1 2 2
MIRT468229 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT474606 KLF3 Kruppel like factor 3 2 2
MIRT476880 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT494065 DUSP2 dual specificity phosphatase 2 2 4
MIRT496020 ZBED3 zinc finger BED-type containing 3 2 2
MIRT496201 EFCAB1 EF-hand calcium binding domain 1 2 2
MIRT499084 ZDHHC21 zinc finger DHHC-type containing 21 2 4
MIRT507188 FZD9 frizzled class receptor 9 2 6
MIRT513283 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT526260 CCDC169 coiled-coil domain containing 169 2 2
MIRT527080 UBE2E3 ubiquitin conjugating enzyme E2 E3 2 2
MIRT528231 SPIN4 spindlin family member 4 2 2
MIRT529764 SF3B1 splicing factor 3b subunit 1 2 2
MIRT530881 SLC18A2 solute carrier family 18 member A2 2 2
MIRT531217 IFNGR2 interferon gamma receptor 2 2 2
MIRT532602 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT533026 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT536151 MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 2 2
MIRT536895 HEPHL1 hephaestin like 1 2 2
MIRT537051 GPR180 G protein-coupled receptor 180 2 2
MIRT537756 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT538736 CALM1 calmodulin 1 2 2
MIRT544276 SEC63 SEC63 homolog, protein translocation regulator 2 2
MIRT546468 SLC1A5 solute carrier family 1 member 5 2 2
MIRT548128 GAS1 growth arrest specific 1 2 2
MIRT548406 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT556717 KLHL21 kelch like family member 21 2 4
MIRT559767 ABHD13 abhydrolase domain containing 13 2 2
MIRT566192 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT566665 NACC2 NACC family member 2 2 2
MIRT573194 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT628350 CCDC117 coiled-coil domain containing 117 2 2
MIRT630464 FOXP1 forkhead box P1 2 2
MIRT645825 INADL PATJ, crumbs cell polarity complex component 2 2
MIRT646288 GPX6 glutathione peroxidase 6 2 2
MIRT646332 ZNF37A zinc finger protein 37A 2 2
MIRT653169 SPPL3 signal peptide peptidase like 3 2 2
MIRT653302 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT654443 RASAL2 RAS protein activator like 2 2 2
MIRT697598 YAP1 Yes associated protein 1 2 2
MIRT699238 SLC6A8 solute carrier family 6 member 8 2 2
MIRT699887 RUNX1 runt related transcription factor 1 2 2
MIRT707267 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT708240 ZNF160 zinc finger protein 160 2 2
MIRT723227 FAM91A1 family with sequence similarity 91 member A1 2 2
MIRT725078 VCPIP1 valosin containing protein interacting protein 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4639-5p Cisplatin approved 84093 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4639 Tripterygium wilfordii Hook F resistant tissue
hsa-miR-4639-5p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-4639-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4639-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)

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