miRTarBase - #MIRT142409


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pre-miRNA Information
pre-miRNA hsa-mir-382   
Genomic Coordinates chr14: 101054306 - 101054381
Synonyms MIRN382, hsa-mir-382, MIR382
Description Homo sapiens miR-382 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-382-3p
Sequence 47| AAUCAUUCACGGACAACACUU |67
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 14 + 101054353 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs370422247 3 dbSNP
rs761809650 7 dbSNP
rs200200058 10 dbSNP
rs755064329 11 dbSNP
rs1397590351 14 dbSNP
rs1382308066 15 dbSNP
rs778937398 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TNRC6A   
Synonyms CAGH26, GW1, GW182, TNRC6
Description trinucleotide repeat containing 6A
Transcript NM_014494   
Expression
Putative miRNA Targets on TNRC6A
3'UTR of TNRC6A
(miRNA target sites are highlighted)		 
>TNRC6A|NM_014494|3'UTR
   1 CAGTGTAGATGCAGACTCACCGACCGGGACCTCAGACGCGAGGGAAAGGAGCACTAAGTGGGGCTCGCCGCCTGCAGCCA
  81 GGGGCCGCCTGTGGGAACAGCTATTCTCTGCACATTTTCCACTTTGTTTTCCCCAAAACATATCAGTTTGAATACTTGAA
 161 TCATGCAGGCCAATATTATAATGTGAAAAGGTATCTACTCTATTTACACTCCCAAATAGCGCCATACATGCTAAACCGTA
 241 GAGAATGAGCTCGCTTGTGTCTATTCATCATGTTTAGCCTTTGGATTCTTTTTTTTTTTTTCCTTCTATTCCTCCCCAAC
 321 CCCCCCCCCCGCCCCTTTTTTTCTCTCTTGCAAAACCATTTTTTGGGCTGATAACGTATGAGCTTTTCCCTTTGCACTGA
 401 ATGATGTTCTCTCCGTCTCATCGGCAGTATGGGGGGCAGCTGTCCCAGTGTCAATGTTTACTCAAGGGTGTTCTTAGGAG
 481 GCGTGCGCTCTCTACTATGCCTTGATGTTGCCTACCTTATTGTGGTATCGTGGAGTTTAAAAGATCAAGTTAGGATGCTG
 561 ACTTAGGATTATTAATGAAAGTGTTGCACCAGTTTTTTCATGTTGTAAAACTAAAGAATTTCGCTCTGCAGTTTGAAAAA
 641 CTGTGGCCACAGCTGTGACTTGCAGCCCACCTGCCACCCAGGACGGGCCCTGCACTTTGAATAGGCTTTCCATTTTGTTT
 721 TGGAGGTTCTCACTTTGAACCTTCTTGTTTACAGATTTTTTTGTTTGTTTTTTGAGAAAAAAAAATGTTTACTCTTCCAT
 801 CATTTAAAAAAAATGTAAAAGACAAAAAAAAAATGGAGGATGATTTAAAAGATGCTTTCTATCTCTGGGAAAAAGGAGCA
 881 GCATTTGGCCATGTTCTTTTGTTTTTCTATTCCTGTCCCAAATCAAAGAGCATGGTTCTCAGGAAAACCAGTTCCCCAGT
 961 TTAAAAAAAAAAAAAAAAATTCCTTGTAGTTTCTTAGAGGAAAAAAAGAAAAACCCCAACTTTTAGCACTGATACTACAT
1041 ATTGCTCTGTTAAAGAATTTTCTCTGCCAAAAAAAAAGAAAAAACAAAAAAACGCTTAAAGCTGGAGTTTGACATTCTGC
1121 TTTCAGATGCTGTCTTTTTATTAGTGAGTGATGATGGTTTGCTAATAATCAATAGGTAATAATTTTTTGTAATCCCATCA
1201 AGTGGCTCCATATGTTTCTGCTCTCTCGTGACTGTGTTAATGTTTAACTGTTGTACCTTAAAGCCGAAATCAGTAACTAT
1281 GCATACTGTAACCAAGGTATTGGGCTTACAGAGTTGTTTGTTGTATAAAGAAAATTTTAAATGTTGTTGCAAACTAACGA
1361 GTTACACCATTTTAAACTTTCTTTCCTCCCCCCTTTTTTTGCCCACAAATGGTATTATAATGCTTGCTTAGTCAAAGAAG
1441 AGAGACTAAACAAGGGTAAAAATTTTAACAGTACAGAATTTGCCATCATATCATTGCCTTGATTCTAACTGTTTGTGTCC
1521 TAAGATGCAAAAGAAGTCAGTGGCTTTTAACTGTTTACAAATAGAATGTGATTGTAAAATGTACAGTTTGGTTGTGTTTG
1601 AATTATGAAATTTCTTCAGATATAATAAACCATGACTTTTTGGCTGCTCAACATTAATTGTCTCCTTTTTGTGAATTTAT
1681 TTGTAGGCTCTTTTTTATAATGAAAGTTTCAAAGTTGCTATGTATGAGGGTTCTCATAGAGCAACCGATTAAAAATCTAA
1761 GCAAATATTTGAACATTTTATCTGAACTCATCACAATTTCACCCTGAAATAATGTGAGAACAATGGGAAACTGTAGCTTG
1841 CTCCTTCCCACCCTCTCTGAGCATCTTTGGGATCTTGTTGCTCAAAACTCTTCTGTGACTTCATCTTCCCCACCATTTGT
1921 GCCCATCTCAAGCCTCAGCAAGAAACCATGTGGAACATGAAGCTTAATGACTTGACAGTGTACTAGTGTTAAACTCTCAT
2001 ACCTCTGTTACAAAGCGAGAAACGCCACACCCGGACTGGCCTTTTCTTCCCCCTTCACGGCCCTCGCTTCTCCCTGCAGG
2081 AGCTCGGGGGCGAAACCTGTGTATGGATTTCAGTGTATGACTTCAGATCATGCTCCAACTTGCCAGGTGTGAGCTAATGT
2161 TGTCGGACACCTTACTATAAGCAAATGTTATTCAGTGCGTTCAATGTATATTGACTTCCATACTGGTTTTTCCAAAAACC
2241 AAAGGTAGCTTTGAAAAACCATGTCTGGAAATGTTTGGAGCGTTAAGCTGATTGACCTTCTGACCTTGGGGCTTTGAGTA
2321 GTATATAATTCATAACTGCGTTAATTGTATTGTTAAAGTGTTTGGGAGTTTTTTGCGCTTGTTATGTGGAAATAAAGTGT
2401 TTGATTTAAAATTTTTTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uucacAACAGGCACUUACUAa 5'
               ||| |  |||||||| 
Target 5' tccctTTG-CACTGAATGATg 3'
 387 - 406 151.00 -7.00
2 
miRNA  3' uucACAACAGGCACUUACUAa 5'
             | || |: ||||:|||| 
Target 5' tctTTTTATTAGTGAGTGATg 3'
 1133 - 1153 146.00 -9.50
3 
miRNA  3' uucaCAACAGGCACUUACUAa 5'
              ||||| : ||||| || 
Target 5' tttgGTTGTGTTTGAATTATg 3'
 1587 - 1607 133.00 -7.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30133739 3 COSMIC
COSN26640182 23 COSMIC
COSN30104763 28 COSMIC
COSN30505010 36 COSMIC
COSN13661912 39 COSMIC
COSN26644775 41 COSMIC
COSN31554333 65 COSMIC
COSN30503522 79 COSMIC
COSN32052917 85 COSMIC
COSN13661913 87 COSMIC
COSN26999352 88 COSMIC
COSN31595426 90 COSMIC
COSN16357193 101 COSMIC
COSN28841103 135 COSMIC
COSN31609355 253 COSMIC
COSN20112785 302 COSMIC
COSN28764158 314 COSMIC
COSN28741179 319 COSMIC
COSN28201856 320 COSMIC
COSN32062117 331 COSMIC
COSN31489885 400 COSMIC
COSN30264726 455 COSMIC
COSN18723483 483 COSMIC
COSN31568063 539 COSMIC
COSN30164829 636 COSMIC
COSN31531085 656 COSMIC
COSN31514805 674 COSMIC
COSN29467725 686 COSMIC
COSN31544911 742 COSMIC
COSN4764850 759 COSMIC
COSN26641120 764 COSMIC
COSN29520813 786 COSMIC
COSN20112786 834 COSMIC
COSN29087179 834 COSMIC
COSN20112788 980 COSMIC
COSN21217512 1127 COSMIC
COSN31584939 1267 COSMIC
COSN31578808 1315 COSMIC
COSN4764851 1338 COSMIC
COSN31538589 1345 COSMIC
COSN28707833 1393 COSMIC
COSN29862008 1401 COSMIC
COSN15843887 1469 COSMIC
COSN30158089 1525 COSMIC
COSN31485454 1610 COSMIC
COSN9644646 1716 COSMIC
COSN31480798 1860 COSMIC
COSN8600964 2004 COSMIC
COSN26249795 2068 COSMIC
COSN31482383 2100 COSMIC
COSN30543619 2106 COSMIC
COSN31520214 2199 COSMIC
COSN31544906 2241 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs779177144 3 dbSNP
rs369775152 10 dbSNP
rs745470864 14 dbSNP
rs1270162234 15 dbSNP
rs1023970521 19 dbSNP
rs769330280 19 dbSNP
rs1332568239 20 dbSNP
rs374024750 21 dbSNP
rs16974119 22 dbSNP
rs980334569 23 dbSNP
rs746587478 26 dbSNP
rs201911975 27 dbSNP
rs1249311568 29 dbSNP
rs1456919705 37 dbSNP
rs1472753107 38 dbSNP
rs776682705 39 dbSNP
rs761484749 40 dbSNP
rs2303083 41 dbSNP
rs772893765 53 dbSNP
rs1262410290 54 dbSNP
rs1194061681 55 dbSNP
rs1448523272 57 dbSNP
rs1264052557 58 dbSNP
rs1355723935 60 dbSNP
rs908259934 60 dbSNP
rs1273937127 63 dbSNP
rs755389115 67 dbSNP
rs1178746567 68 dbSNP
rs1400927151 70 dbSNP
rs939862013 71 dbSNP
rs1385910230 79 dbSNP
rs1051658542 87 dbSNP
rs889777251 88 dbSNP
rs1463630403 91 dbSNP
rs919879189 92 dbSNP
rs942733243 104 dbSNP
rs1476262573 124 dbSNP
rs575497066 132 dbSNP
rs894481097 137 dbSNP
rs544392597 144 dbSNP
rs1172596956 145 dbSNP
rs1253892723 174 dbSNP
rs1014650402 183 dbSNP
rs904469402 190 dbSNP
rs1456507383 193 dbSNP
rs1257917848 194 dbSNP
rs531083358 198 dbSNP
rs1031494838 199 dbSNP
rs1273489577 205 dbSNP
rs1233010164 210 dbSNP
rs1371220917 214 dbSNP
rs1327503262 215 dbSNP
rs1373273486 221 dbSNP
rs1446212425 238 dbSNP
rs564258009 239 dbSNP
rs1399770712 248 dbSNP
rs1171732037 253 dbSNP
rs533190289 254 dbSNP
rs1395850221 256 dbSNP
rs1195751774 258 dbSNP
rs1437896123 261 dbSNP
rs1013986683 262 dbSNP
rs1033139033 268 dbSNP
rs1440009295 271 dbSNP
rs1277152639 286 dbSNP
rs1200166898 288 dbSNP
rs11335420 289 dbSNP
rs1237593304 289 dbSNP
rs1349064112 289 dbSNP
rs1375477054 290 dbSNP
rs1186400777 300 dbSNP
rs893270640 300 dbSNP
rs865915359 302 dbSNP
rs1357319424 303 dbSNP
rs1396688562 303 dbSNP
rs1374591517 304 dbSNP
rs1391307471 307 dbSNP
rs1307776778 308 dbSNP
rs1350104018 309 dbSNP
rs1056420243 311 dbSNP
rs1235153044 312 dbSNP
rs1279817104 313 dbSNP
rs1177809167 314 dbSNP
rs892440438 314 dbSNP
rs1346003910 316 dbSNP
rs200245697 318 dbSNP
rs1010087111 319 dbSNP
rs1402582098 319 dbSNP
rs1284561404 320 dbSNP
rs867798764 320 dbSNP
rs879222639 320 dbSNP
rs66925397 321 dbSNP
rs1206269601 322 dbSNP
rs878994148 322 dbSNP
rs1163153307 323 dbSNP
rs1260258273 323 dbSNP
rs1191907780 324 dbSNP
rs1251671369 324 dbSNP
rs1480222810 325 dbSNP
rs1175393120 326 dbSNP
rs1276230290 327 dbSNP
rs1288580366 327 dbSNP
rs1362463970 328 dbSNP
rs1433203814 329 dbSNP
rs1325246613 330 dbSNP
rs1462061800 330 dbSNP
rs1169181841 331 dbSNP
rs55802473 331 dbSNP
rs112183094 332 dbSNP
rs1192489844 336 dbSNP
rs1392815798 337 dbSNP
rs1411293353 338 dbSNP
rs1043624 346 dbSNP
rs1487331040 346 dbSNP
rs1043625 348 dbSNP
rs1024503036 358 dbSNP
rs1469426321 365 dbSNP
rs1170779300 366 dbSNP
rs1218008638 369 dbSNP
rs1307828716 373 dbSNP
rs1297516608 374 dbSNP
rs1355453287 374 dbSNP
rs760479079 376 dbSNP
rs1461831405 377 dbSNP
rs878866995 381 dbSNP
rs1001217039 395 dbSNP
rs1017156606 397 dbSNP
rs1302957628 403 dbSNP
rs1441655141 408 dbSNP
rs1373854047 415 dbSNP
rs546715936 416 dbSNP
rs973430665 420 dbSNP
rs918762935 421 dbSNP
rs779105071 424 dbSNP
rs576408519 431 dbSNP
rs1355459542 432 dbSNP
rs1302768802 436 dbSNP
rs1431804843 438 dbSNP
rs748894948 443 dbSNP
rs955755328 444 dbSNP
rs986891322 446 dbSNP
rs1394035647 450 dbSNP
rs1193935849 454 dbSNP
rs911319646 455 dbSNP
rs1216538980 461 dbSNP
rs942681028 471 dbSNP
rs150174727 472 dbSNP
rs1043710560 475 dbSNP
rs560234888 482 dbSNP
rs748479348 483 dbSNP
rs986856173 484 dbSNP
rs925320403 486 dbSNP
rs935916126 487 dbSNP
rs1306676095 488 dbSNP
rs1202224529 490 dbSNP
rs768415036 491 dbSNP
rs961113049 493 dbSNP
rs1274921731 495 dbSNP
rs1053470297 501 dbSNP
rs1300428240 505 dbSNP
rs973937835 515 dbSNP
rs1375291052 516 dbSNP
rs1173839740 522 dbSNP
rs891612633 528 dbSNP
rs1212451751 530 dbSNP
rs1378122104 531 dbSNP
rs774123661 532 dbSNP
rs1419159061 545 dbSNP
rs1250582823 546 dbSNP
rs1252509111 550 dbSNP
rs1180107051 554 dbSNP
rs919767756 561 dbSNP
rs1280835270 562 dbSNP
rs1045459530 572 dbSNP
rs1350267630 576 dbSNP
rs905612639 577 dbSNP
rs1001166125 579 dbSNP
rs1238343129 587 dbSNP
rs1476136599 592 dbSNP
rs1016604529 593 dbSNP
rs1186712229 596 dbSNP
rs962411048 600 dbSNP
rs1309777551 601 dbSNP
rs990772995 602 dbSNP
rs1355198123 603 dbSNP
rs1313814681 624 dbSNP
rs994414411 625 dbSNP
rs1417043104 627 dbSNP
rs1358160109 642 dbSNP
rs1418388093 650 dbSNP
rs1453838739 671 dbSNP
rs917798146 685 dbSNP
rs1428236724 686 dbSNP
rs1168997978 688 dbSNP
rs528845451 690 dbSNP
rs1474869754 694 dbSNP
rs548967496 699 dbSNP
rs950109451 702 dbSNP
rs772615375 713 dbSNP
rs1487190785 718 dbSNP
rs1397236345 728 dbSNP
rs1045691501 730 dbSNP
rs1204839267 737 dbSNP
rs1462418602 738 dbSNP
rs1351449665 742 dbSNP
rs1325899374 748 dbSNP
rs10055 749 dbSNP
rs1242727201 756 dbSNP
rs1348185379 760 dbSNP
rs138636233 775 dbSNP
rs1054429219 777 dbSNP
rs1235463688 777 dbSNP
rs1294450392 777 dbSNP
rs1382476630 777 dbSNP
rs934753446 777 dbSNP
rs955539099 778 dbSNP
rs893323279 790 dbSNP
rs1270953756 803 dbSNP
rs1476713169 806 dbSNP
rs997395454 806 dbSNP
rs1372326954 808 dbSNP
rs1278892086 816 dbSNP
rs193262905 817 dbSNP
rs1294908218 822 dbSNP
rs1447748229 824 dbSNP
rs1468102165 824 dbSNP
rs35671423 824 dbSNP
rs397829930 824 dbSNP
rs879188852 824 dbSNP
rs1335300558 825 dbSNP
rs1274340571 826 dbSNP
rs1216171426 837 dbSNP
rs1337822459 841 dbSNP
rs1228645980 855 dbSNP
rs911268276 856 dbSNP
rs1439451872 861 dbSNP
rs185042220 862 dbSNP
rs1394663434 865 dbSNP
rs1327798740 868 dbSNP
rs1287689755 874 dbSNP
rs1464042197 875 dbSNP
rs891351489 892 dbSNP
rs551689737 900 dbSNP
rs1168241207 904 dbSNP
rs1448181302 914 dbSNP
rs1374943373 926 dbSNP
rs1192052129 932 dbSNP
rs964105251 934 dbSNP
rs1215907557 958 dbSNP
rs1241098031 959 dbSNP
rs1253750783 960 dbSNP
rs116438855 963 dbSNP
rs1233158764 963 dbSNP
rs1304927273 963 dbSNP
rs1371061099 963 dbSNP
rs35913858 963 dbSNP
rs397855166 963 dbSNP
rs72532675 963 dbSNP
rs869109492 963 dbSNP
rs1443973774 964 dbSNP
rs1484689270 966 dbSNP
rs1335026341 978 dbSNP
rs1189706489 980 dbSNP
rs1411435639 981 dbSNP
rs1399884866 985 dbSNP
rs1007431921 994 dbSNP
rs571483770 998 dbSNP
rs1434391880 1001 dbSNP
rs1395946878 1009 dbSNP
rs36060292 1009 dbSNP
rs1195537307 1020 dbSNP
rs1468673016 1024 dbSNP
rs1232754449 1028 dbSNP
rs1420460636 1033 dbSNP
rs979524988 1035 dbSNP
rs773704200 1052 dbSNP
rs1015259110 1068 dbSNP
rs1348102276 1069 dbSNP
rs201286178 1069 dbSNP
rs960999801 1069 dbSNP
rs925267973 1070 dbSNP
rs935357786 1076 dbSNP
rs1349402290 1078 dbSNP
rs3088119 1079 dbSNP
rs1280061563 1081 dbSNP
rs1053012958 1082 dbSNP
rs1353308819 1086 dbSNP
rs80182361 1087 dbSNP
rs949325592 1094 dbSNP
rs949873439 1095 dbSNP
rs553837294 1097 dbSNP
rs1399015013 1113 dbSNP
rs1407396849 1118 dbSNP
rs1159627021 1121 dbSNP
rs934638250 1122 dbSNP
rs905730506 1127 dbSNP
rs1187594811 1129 dbSNP
rs1054481936 1130 dbSNP
rs1486210117 1130 dbSNP
rs893197533 1135 dbSNP
rs1001284153 1141 dbSNP
rs770506862 1143 dbSNP
rs1398381340 1144 dbSNP
rs539021916 1145 dbSNP
rs1355820914 1149 dbSNP
rs1050344747 1157 dbSNP
rs1037812917 1163 dbSNP
rs898153033 1166 dbSNP
rs1413973224 1167 dbSNP
rs1282307294 1168 dbSNP
rs1292606364 1173 dbSNP
rs1352763474 1177 dbSNP
rs1357201992 1180 dbSNP
rs1304809600 1181 dbSNP
rs1428941427 1190 dbSNP
rs868060435 1192 dbSNP
rs1008493554 1193 dbSNP
rs760639252 1200 dbSNP
rs1458888549 1208 dbSNP
rs1025872658 1209 dbSNP
rs1164901670 1215 dbSNP
rs1475736868 1224 dbSNP
rs189025884 1228 dbSNP
rs1008362925 1229 dbSNP
rs1474849791 1241 dbSNP
rs1212555989 1242 dbSNP
rs1018393872 1258 dbSNP
rs964203326 1265 dbSNP
rs1257839390 1266 dbSNP
rs995144566 1267 dbSNP
rs1486182883 1272 dbSNP
rs1187710977 1276 dbSNP
rs979473104 1284 dbSNP
rs1293113046 1294 dbSNP
rs765241966 1294 dbSNP
rs191600386 1298 dbSNP
rs1361449008 1299 dbSNP
rs988548091 1320 dbSNP
rs1271002663 1324 dbSNP
rs868193337 1326 dbSNP
rs1026764020 1342 dbSNP
rs79620110 1344 dbSNP
rs77976341 1345 dbSNP
rs76813619 1346 dbSNP
rs1417980432 1350 dbSNP
rs959365363 1359 dbSNP
rs949999100 1360 dbSNP
rs1168730341 1364 dbSNP
rs1175716637 1365 dbSNP
rs981397617 1370 dbSNP
rs927095140 1380 dbSNP
rs1413875062 1386 dbSNP
rs1452031872 1387 dbSNP
rs1251884340 1388 dbSNP
rs1331951228 1388 dbSNP
rs937188457 1388 dbSNP
rs1025222558 1389 dbSNP
rs1469729596 1390 dbSNP
rs1038099680 1393 dbSNP
rs1273940023 1394 dbSNP
rs1307915253 1394 dbSNP
rs35836582 1394 dbSNP
rs970546130 1395 dbSNP
rs1278940799 1401 dbSNP
rs1368857721 1402 dbSNP
rs1302689379 1407 dbSNP
rs977996672 1408 dbSNP
rs1373975437 1413 dbSNP
rs1235901186 1418 dbSNP
rs898257964 1419 dbSNP
rs1355517260 1428 dbSNP
rs1346721124 1445 dbSNP
rs1432423160 1449 dbSNP
rs923830155 1456 dbSNP
rs576394480 1462 dbSNP
rs956068707 1470 dbSNP
rs1200171330 1472 dbSNP
rs929619405 1474 dbSNP
rs1480834616 1476 dbSNP
rs1234453386 1477 dbSNP
rs184118898 1479 dbSNP
rs1208482486 1481 dbSNP
rs1345910110 1486 dbSNP
rs1279916649 1489 dbSNP
rs1439978852 1490 dbSNP
rs1314067826 1493 dbSNP
rs1305447370 1498 dbSNP
rs551106658 1505 dbSNP
rs745330343 1505 dbSNP
rs990088164 1506 dbSNP
rs914699235 1511 dbSNP
rs1413360103 1516 dbSNP
rs1374426911 1528 dbSNP
rs188128492 1529 dbSNP
rs1467105435 1531 dbSNP
rs890831582 1538 dbSNP
rs1361631637 1541 dbSNP
rs752758385 1545 dbSNP
rs1158272973 1554 dbSNP
rs1195591684 1556 dbSNP
rs1395846010 1566 dbSNP
rs369706946 1567 dbSNP
rs1018509781 1570 dbSNP
rs1185479729 1575 dbSNP
rs577904467 1577 dbSNP
rs1257046007 1580 dbSNP
rs1171094173 1581 dbSNP
rs1001006648 1582 dbSNP
rs1484272608 1586 dbSNP
rs1259094537 1591 dbSNP
rs1238432731 1592 dbSNP
rs1254576901 1595 dbSNP
rs1318009435 1595 dbSNP
rs1398333611 1597 dbSNP
rs763086256 1600 dbSNP
rs912726818 1601 dbSNP
rs1313109035 1602 dbSNP
rs540438858 1624 dbSNP
rs1328057259 1627 dbSNP
rs1287711695 1628 dbSNP
rs1037302188 1630 dbSNP
rs988275384 1633 dbSNP
rs1162764718 1639 dbSNP
rs867034602 1640 dbSNP
rs995195575 1647 dbSNP
rs1418387312 1650 dbSNP
rs1025392096 1652 dbSNP
rs1048533370 1653 dbSNP
rs1303510028 1665 dbSNP
rs1259956439 1674 dbSNP
rs1425718331 1674 dbSNP
rs1204585074 1676 dbSNP
rs764190009 1701 dbSNP
rs1270544261 1703 dbSNP
rs894929421 1707 dbSNP
rs559946325 1713 dbSNP
rs181078542 1738 dbSNP
rs186087349 1745 dbSNP
rs927210752 1746 dbSNP
rs999302180 1747 dbSNP
rs190211962 1748 dbSNP
rs957943606 1755 dbSNP
rs1366786657 1761 dbSNP
rs937134435 1766 dbSNP
rs531231431 1772 dbSNP
rs767953715 1779 dbSNP
rs973905177 1780 dbSNP
rs919653203 1783 dbSNP
rs1164742472 1787 dbSNP
rs954032781 1795 dbSNP
rs551653455 1797 dbSNP
rs929708337 1802 dbSNP
rs1450165106 1804 dbSNP
rs1250045572 1808 dbSNP
rs1257912741 1813 dbSNP
rs141990413 1824 dbSNP
rs1046833720 1829 dbSNP
rs985968369 1831 dbSNP
rs912200437 1832 dbSNP
rs534084985 1837 dbSNP
rs943719294 1854 dbSNP
rs1211953285 1856 dbSNP
rs912621448 1877 dbSNP
rs1250379287 1886 dbSNP
rs1228768420 1889 dbSNP
rs547586241 1892 dbSNP
rs1300550772 1908 dbSNP
rs1439522197 1910 dbSNP
rs1253689036 1933 dbSNP
rs1432721363 1937 dbSNP
rs944218049 1939 dbSNP
rs1389433601 1946 dbSNP
rs1395594813 1947 dbSNP
rs900094758 1964 dbSNP
rs1454602530 1970 dbSNP
rs778941746 1971 dbSNP
rs1430583523 1979 dbSNP
rs1054352714 1980 dbSNP
rs1171802186 1983 dbSNP
rs1453894137 1995 dbSNP
rs918883359 1997 dbSNP
rs1201695252 2004 dbSNP
rs74015711 2013 dbSNP
rs1010049554 2017 dbSNP
rs879110567 2018 dbSNP
rs1277780139 2024 dbSNP
rs1326565656 2025 dbSNP
rs756705994 2025 dbSNP
rs1276545028 2030 dbSNP
rs1002226022 2033 dbSNP
rs1034228659 2034 dbSNP
rs1411464524 2042 dbSNP
rs1372588567 2044 dbSNP
rs1311344241 2045 dbSNP
rs1319826413 2049 dbSNP
rs1046598573 2052 dbSNP
rs1174812412 2058 dbSNP
rs1469000729 2059 dbSNP
rs958620645 2060 dbSNP
rs1363729406 2062 dbSNP
rs1183293171 2066 dbSNP
rs1326671550 2067 dbSNP
rs906271272 2073 dbSNP
rs1280057997 2079 dbSNP
rs999354569 2082 dbSNP
rs1030783889 2087 dbSNP
rs536766085 2092 dbSNP
rs1011241283 2093 dbSNP
rs1353371676 2099 dbSNP
rs1291662241 2100 dbSNP
rs919753426 2102 dbSNP
rs951273652 2106 dbSNP
rs1028888050 2117 dbSNP
rs954198787 2125 dbSNP
rs556411473 2131 dbSNP
rs576382001 2132 dbSNP
rs201860970 2139 dbSNP
rs1416224219 2142 dbSNP
rs1187698419 2150 dbSNP
rs1208159015 2158 dbSNP
rs1472885192 2158 dbSNP
rs912332484 2165 dbSNP
rs557866811 2166 dbSNP
rs1020141264 2167 dbSNP
rs943668363 2170 dbSNP
rs1445964771 2176 dbSNP
rs748807150 2178 dbSNP
rs1210585543 2189 dbSNP
rs539078650 2199 dbSNP
rs1272246284 2200 dbSNP
rs763085702 2202 dbSNP
rs146301282 2205 dbSNP
rs868243154 2207 dbSNP
rs1054065308 2218 dbSNP
rs1476094545 2218 dbSNP
rs892616522 2225 dbSNP
rs1165511560 2232 dbSNP
rs867028679 2236 dbSNP
rs1009753061 2240 dbSNP
rs1459234854 2245 dbSNP
rs1046897220 2259 dbSNP
rs578002884 2263 dbSNP
rs1164470514 2274 dbSNP
rs540403665 2281 dbSNP
rs1002171897 2283 dbSNP
rs553951215 2284 dbSNP
rs1474792352 2309 dbSNP
rs1455882908 2317 dbSNP
rs182444420 2326 dbSNP
rs1467028526 2328 dbSNP
rs576336798 2333 dbSNP
rs916823819 2334 dbSNP
rs947733138 2337 dbSNP
rs778408080 2340 dbSNP
rs747858867 2341 dbSNP
rs771725778 2350 dbSNP
rs772996631 2355 dbSNP
rs770332920 2359 dbSNP
rs906325421 2360 dbSNP
rs542683022 2363 dbSNP
rs1437409643 2364 dbSNP
rs1338855621 2366 dbSNP
rs1293510254 2367 dbSNP
rs1052093331 2369 dbSNP
rs951265383 2372 dbSNP
rs562488289 2377 dbSNP
rs1294396439 2378 dbSNP
rs531196991 2386 dbSNP
rs1010712481 2387 dbSNP
rs1029354482 2398 dbSNP
rs1242618088 2409 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166 , TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000395799.3 | 3UTR | CUUUUCCCUUUGCACUGAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000395799.3 | 3UTR | CUUUUCCCUUUGCACUGAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000395799.3 | 3UTR | CUUUUCCCUUUGCACUGAAUGAUGUUCUCUCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000395799.3 | 3UTR | AUGAGCUUUUCCCUUUGCACUGAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
79 hsa-miR-382-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT062248 HP1BP3 heterochromatin protein 1 binding protein 3 1 1
MIRT068067 SPATA13 spermatogenesis associated 13 2 4
MIRT142409 TNRC6A trinucleotide repeat containing 6A 2 6
MIRT257487 ABT1 activator of basal transcription 1 2 6
MIRT439244 ZCRB1 zinc finger CCHC-type and RNA binding motif containing 1 1 1
MIRT439345 UHMK1 U2AF homology motif kinase 1 1 1
MIRT439466 TGFBR3 transforming growth factor beta receptor 3 1 1
MIRT439506 SURF4 surfeit 4 1 1
MIRT439733 RPS4X ribosomal protein S4, X-linked 1 1
MIRT439888 PRUNE2 prune homolog 2 1 1
MIRT439984 PHLDB2 pleckstrin homology like domain family B member 2 1 1
MIRT440132 NCOA3 nuclear receptor coactivator 3 1 1
MIRT440291 MAP2 microtubule associated protein 2 1 1
MIRT440434 IPPK inositol-pentakisphosphate 2-kinase 1 1
MIRT440515 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1 1
MIRT440723 ENO2 enolase 2 1 1
MIRT440898 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT441013 CAPN7 calpain 7 1 1
MIRT448953 CDK19 cyclin dependent kinase 19 2 2
MIRT466663 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 4
MIRT471447 PDIA5 protein disulfide isomerase family A member 5 2 2
MIRT496398 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT497519 EXOC8 exocyst complex component 8 2 2
MIRT501782 NRBF2 nuclear receptor binding factor 2 2 6
MIRT504199 KIAA1586 KIAA1586 2 4
MIRT505076 ZC3H12C zinc finger CCCH-type containing 12C 2 8
MIRT509814 SULT1B1 sulfotransferase family 1B member 1 2 4
MIRT518477 C8orf37 chromosome 8 open reading frame 37 2 4
MIRT520345 UBN2 ubinuclein 2 2 10
MIRT527579 BRD7 bromodomain containing 7 2 4
MIRT531742 TXK TXK tyrosine kinase 2 2
MIRT533354 UBE2W ubiquitin conjugating enzyme E2 W 2 2
MIRT535735 MYO6 myosin VI 2 2
MIRT537113 GP5 glycoprotein V platelet 2 4
MIRT542398 TFCP2 transcription factor CP2 2 8
MIRT547560 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT551649 CCDC127 coiled-coil domain containing 127 2 2
MIRT554959 RACGAP1 Rac GTPase activating protein 1 2 2
MIRT555202 PRRX1 paired related homeobox 1 2 2
MIRT555768 PCTP phosphatidylcholine transfer protein 2 2
MIRT558971 CALM1 calmodulin 1 2 2
MIRT559668 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT566688 MYLIP myosin regulatory light chain interacting protein 2 2
MIRT568588 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT568643 ACTB actin beta 2 2
MIRT568775 LY6K lymphocyte antigen 6 family member K 2 2
MIRT573442 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT611400 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT623867 GABRB2 gamma-aminobutyric acid type A receptor beta2 subunit 2 2
MIRT627266 XKR4 XK related 4 2 2
MIRT631666 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT635085 LIMS3 LIM zinc finger domain containing 3 2 2
MIRT635154 LIMS3L LIM zinc finger domain containing 4 2 2
MIRT639057 FPR1 formyl peptide receptor 1 2 2
MIRT642763 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT643385 CLMP CXADR like membrane protein 2 2
MIRT647390 ZNF616 zinc finger protein 616 2 2
MIRT647435 ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2 2
MIRT649067 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT653017 STX7 syntaxin 7 2 2
MIRT654321 RBM47 RNA binding motif protein 47 2 2
MIRT654773 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 2 2
MIRT657853 GJD3 gap junction protein delta 3 2 2
MIRT662944 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT698739 STX12 syntaxin 12 2 2
MIRT699384 SLC30A6 solute carrier family 30 member 6 2 2
MIRT700215 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT702626 ITGBL1 integrin subunit beta like 1 2 2
MIRT709824 STPG1 sperm tail PG-rich repeat containing 1 2 2
MIRT711075 NLGN2 neuroligin 2 2 2
MIRT712835 GJD2 gap junction protein delta 2 2 2
MIRT713307 TYRP1 tyrosinase related protein 1 2 2
MIRT713726 CD244 CD244 molecule 2 2
MIRT715558 EPT1 selenoprotein I 2 2
MIRT717285 TRAF1 TNF receptor associated factor 1 2 2
MIRT724543 RSL24D1 ribosomal L24 domain containing 1 2 2
MIRT735691 SMAD2 SMAD family member 2 2 0
MIRT755903 SLIT2 slit guidance ligand 2 3 1
MIRT756166 SAE1 SUMO1 activating enzyme subunit 1 5 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-382 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-382 Morphine approved 5288826 Quantitative real-time PCR HIV 21224041 2011 down-regulated
miR-382 Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 down-regulated
miR-382 Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 down-regulated
miR-382 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-382 Propranolol approved 4946 Quantitative real-time PCR heart 22847192 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-382 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-382 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-382-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HCT-116)
hsa-miR-382-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-382-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-382-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-382-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (HCT116)
hsa-miR-382-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-382-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-382-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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