miRTarBase - #MIRT143520


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pre-miRNA Information
pre-miRNA hsa-mir-433   
Genomic Coordinates chr14: 100881886 - 100881978
Synonyms MIRN433, hsa-mir-433, miRNA433, MIR433
Description Homo sapiens miR-433 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-433-3p
Sequence 64| AUCAUGAUGGGCUCCUCGGUGU |85
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM8969374 10 COSMIC
COSM6770363 11 COSMIC
COSM381402 17 COSMIC
COSM8924941 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757633556 8 dbSNP
rs781425496 17 dbSNP
rs1261819806 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CHD9   
Synonyms AD013, CHD-9, CReMM, KISH2, PRIC320
Description chromodomain helicase DNA binding protein 9
Transcript NM_025134   
Expression
Putative miRNA Targets on CHD9
3'UTR of CHD9
(miRNA target sites are highlighted)		 
>CHD9|NM_025134|3'UTR
   1 TTCCCAGACTCTGCACTTAAAATATGAACTGATTTTGGATTTTTTCTTTAATAATTAATTGTAAATACCCCAGTGTTGAG
  81 TGCATCAATAACTTACTGACCGAACATTTCAGTTATTTGTTTAGAAGTGCAAACTGCTTTCAGAGACTTTTTGCATGTAA
 161 TATTTCTTAAGATTCATAAGTTTCTGAACTCGTATGTACTATCAAATACATAAAGGTGTAAAATTACAACAAAAGGCATT
 241 ATAATTTTGTTGGGGGTTAATTTTATGAAAATTATGCTCAATAAGAGTTGTATATTTAATATATTTGCAGTGAACACAGA
 321 ATACTTTATGCATATTACTGATTTAATTTGAATATAGTTTTACAGCCTCCTTGACACCTATAATTTACAGATCAAAACTC
 401 AGCAATAATTTGGGCAGCTAATGAATGTCATGAAAGCTGTAGAATCTACATCACCATCCATTGCTTTAATTACATGAAAA
 481 TGCTCTAGTGTTGTGATGCACTGCTGATGTTTCCAATTCAGGTACAAGTATGTTTTAAAGAAGAAATAAGTTTCCCAATC
 561 AGCCAATTTAACTGGCTACCTGTTACCTCAGCTGAGTTAGTTTAGGAAGTTTACATTCGTTTCTAATTCTATACTTGTTT
 641 TCAGGGGTTTTTTAAACACATCCTATATATCATGTCAATCTGGCAAGAAATATGACTTGCTTTTTGCTGAGCTTAATTCA
 721 GATATCAGTAAAATTAAGTCATAAAATAATCATGTGTCATGTGACTTTGGCACCCTATAGACATACTTAGTTTTAACTTT
 801 TCAAAGTTTGGCCTCCTATTAGAAATAATCATGTCTCAGATGAGTAATGTCTGTTTCCAGGGTTCAGAAAAGGCAAACTC
 881 ATGAAATGCCACTGAAAAGAACTTTCAACACAGCATACTTCATGTAAAAGAAATTGTTTGTTTGCTTTCTTTGTGTAGAT
 961 TTCTATTTGTGTTTTATGTCATGGAAATATTCCAGAATTAACAGATAATAGTGGTAAAGTAATATGCAGATAGTCTAAAT
1041 TCATTTTGAGTTTCTAGGTGTAAGCAGACTAAATGTTGCCCAGAATCAGTGTTGGGTTATCAGTTTATATTAAATATACT
1121 GAGTTGCCCGTTTTGAAAATGCACTTTGAATAATCTCAAAAAGATGTACAAGTTATACCTGTAAACCACAAAAGTGAAGC
1201 CTGAGGCTTCTGTTCAATTTCATAGACTCCTTTACCATGTAAAATTTGTCTGATATTTGATTTGTGATACAATTTCTCCT
1281 GCTAAAGCTGCTATTATTCTGACAAGGTAGAGGTCCAGGTTCACCTTTATATATATTTAAAACAATTAGTACTGAATTGG
1361 ACATAAAAATATTGACATTCTAAGGAGAGATATATGTTAGCATTTTTCTGGTACTCAAATAAGTTAGTAGTAAAGTCTGC
1441 AAGGGCATAAATTTAGGGGGAAAAAGTGTCCCAGTTCTCTCCTACAGAAAAAATACTTTCAGTATGTTTTGATAAAACTG
1521 TTGCTTTGTCATGAGTTAGTCAATTGTATCAGGTTTTCCAAGACCTTTACCAGTAAATTATGTTTCTGTATGTAAAATAA
1601 CCCCTTATTAGAGAGACAGTGTTATATGTATTTACAAAATTATATAAGTTCCATTGGGATTGTATTGATTTTGTATTTTC
1681 CCAAAATAGTACTTTGAATTGATAGTCCTTTATGCAATGTCTTAGCAATAGTCTCTATAATGCCCATCCAGGAGAAGTGG
1761 GTAGTAATTCTTCATCATGAAAATGATATATTACATATTTAGTATCTTCCCTTTGCAGTATTGCACTTTTGTTTAACTAG
1841 AATACACCTATGAGATAGCCAAAGTTTCAAACACAGTTATCTTAGTTTACCGGTGGAGTATTTCAACACCAACCACATTT
1921 CCCTTCCTCCCTCTAATTCTACCCACATGATCTTTATTCCTTCCTTTCGCCAATTAAAAAAAAAAAAAAGGAAAAAAAAT
2001 CTGTAGATCTTGTCACTAAAATCTAATTTATATCAAATTTATGAGAGAAAGTATTTTCCTAATTATGGTCAAATAAATTT
2081 GGTTAACATCCTAGTGATTCTCTTTCTATATAATAAGGCAATTACAGTTTTCAAAGCATTAAGTCTAACATAACTTTAAA
2161 CATTCTCTTAGGTTTCAAGACACTTCTATTTAATATTCATTGGGGAAAAGTTGTCCAGCTATCAGCTAAGAAAACACATG
2241 CAAATATGGTTGTGTAAAGTTAAGGGTTATAAGGAAAAAAAAATCAGTAGAATTACATAATACTAAAGTTGCAGTTGAAA
2321 GAATATCCAAGTATGTGTTGGTAGTTACTAAAAGAATTATAGCTGTTATTGCCTTGTATTTATAGCCCTTGTTTCAGGTT
2401 TTATGATTCAAGTCTTAGTCCAATCTTTCTTTTGGACATTTGCAATATTTACCAGTTGTGTTTTGTGTAGTCTGAATTTG
2481 CTTTCTGTAGTTGAGCAAACGTCTTAAAAAGTCATTTGTAATTTATTAAATTACTTTCTATGATGTTCTATAGAGCAAAT
2561 GGAAGTTTAATTATTTTTTATTAAACATATTCTTTGACTACCCATGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugUGGCUCCUC------GGGUAGUACUa 5'
            | :|:| ||      ::|||||||| 
Target 5' gaAGTGGGTAGTAATTCTTCATCATGAa 3'
 1754 - 1781 150.00 -13.90
2 
miRNA  3' uguGGCUCCUCGG------GUAGUACUa 5'
             ::|:| |||:      ::|||||| 
Target 5' aatTTGGGCAGCTAATGAATGTCATGAa 3'
 407 - 434 133.00 -11.00
3 
miRNA  3' ugUGGCUCCUCGGGUAGUACUa 5'
            ||:|  |  ::::|||||| 
Target 5' aaACTGTTG-CTTTGTCATGAg 3'
 1515 - 1535 131.00 -10.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN17215231 27 COSMIC
COSN30533050 45 COSMIC
COSN31546879 167 COSMIC
COSN6086596 272 COSMIC
COSN31566474 359 COSMIC
COSN31589333 424 COSMIC
COSN20229761 483 COSMIC
COSN31519196 569 COSMIC
COSN6086597 714 COSMIC
COSN31515183 752 COSMIC
COSN31539525 1015 COSMIC
COSN31523332 1052 COSMIC
COSN5835225 1451 COSMIC
COSN31563212 1519 COSMIC
COSN31482951 1551 COSMIC
COSN29462913 1659 COSMIC
COSN26562664 1663 COSMIC
COSN31584760 1687 COSMIC
COSN31482896 1736 COSMIC
COSN31535746 1788 COSMIC
COSN20112883 1875 COSMIC
COSN20112885 1990 COSMIC
COSN31520593 1996 COSMIC
COSN31515485 2002 COSMIC
COSN31579001 2050 COSMIC
COSN30538660 2059 COSMIC
COSN31541020 2060 COSMIC
COSN18983081 2154 COSMIC
COSN31602576 2284 COSMIC
COSN31513255 2304 COSMIC
COSN7260289 2475 COSMIC
COSN26268326 2511 COSMIC
COSN26266926 2514 COSMIC
COSN26602262 2571 COSMIC
COSN28798383 2593 COSMIC
COSN31515609 2593 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs970481539 5 dbSNP
rs1452780165 8 dbSNP
rs778257749 10 dbSNP
rs1416123704 14 dbSNP
rs980304309 15 dbSNP
rs747574464 17 dbSNP
rs757775970 19 dbSNP
rs1384335457 22 dbSNP
rs1226244462 23 dbSNP
rs1308964970 26 dbSNP
rs201410095 28 dbSNP
rs1397763253 40 dbSNP
rs974039999 40 dbSNP
rs748773116 47 dbSNP
rs1283822428 49 dbSNP
rs553697280 50 dbSNP
rs1028428690 76 dbSNP
rs147508306 83 dbSNP
rs560478942 84 dbSNP
rs1446621603 85 dbSNP
rs577320612 89 dbSNP
rs1178029138 98 dbSNP
rs1473757643 102 dbSNP
rs1053258291 103 dbSNP
rs1209177075 129 dbSNP
rs1197403312 133 dbSNP
rs1353950996 134 dbSNP
rs546261907 135 dbSNP
rs562748910 147 dbSNP
rs986874964 149 dbSNP
rs1448294181 156 dbSNP
rs1216868276 172 dbSNP
rs531666075 177 dbSNP
rs769382413 187 dbSNP
rs945152254 188 dbSNP
rs1440820879 195 dbSNP
rs1040544152 197 dbSNP
rs1331425958 200 dbSNP
rs1191895056 204 dbSNP
rs1385504095 217 dbSNP
rs575247018 219 dbSNP
rs1164568584 234 dbSNP
rs925188315 238 dbSNP
rs1378634134 239 dbSNP
rs936345210 241 dbSNP
rs996271546 250 dbSNP
rs1233423717 252 dbSNP
rs548046691 254 dbSNP
rs1449746749 264 dbSNP
rs1163259305 266 dbSNP
rs1222867314 267 dbSNP
rs1361230460 275 dbSNP
rs1283435034 277 dbSNP
rs1222750121 281 dbSNP
rs1411706022 286 dbSNP
rs1421652994 287 dbSNP
rs887733224 298 dbSNP
rs1298999857 308 dbSNP
rs1360084144 309 dbSNP
rs1280741665 314 dbSNP
rs762964130 316 dbSNP
rs894783770 318 dbSNP
rs1314419559 322 dbSNP
rs1340845900 324 dbSNP
rs949177143 325 dbSNP
rs1243970957 326 dbSNP
rs1282414941 332 dbSNP
rs561940975 337 dbSNP
rs1240193199 343 dbSNP
rs1014731303 355 dbSNP
rs1284713601 356 dbSNP
rs907370367 357 dbSNP
rs1410283386 359 dbSNP
rs1212585905 367 dbSNP
rs1258701048 369 dbSNP
rs1479417884 371 dbSNP
rs896323696 381 dbSNP
rs542518742 400 dbSNP
rs1199966620 403 dbSNP
rs1490770763 416 dbSNP
rs1187438755 430 dbSNP
rs1214662931 431 dbSNP
rs1004328636 454 dbSNP
rs1236278093 465 dbSNP
rs1285756348 466 dbSNP
rs1442116406 469 dbSNP
rs1198176402 472 dbSNP
rs1015835435 475 dbSNP
rs898731333 486 dbSNP
rs758339417 490 dbSNP
rs1338870678 492 dbSNP
rs547096198 497 dbSNP
rs1379777308 515 dbSNP
rs1024834648 523 dbSNP
rs1431787879 529 dbSNP
rs995495263 531 dbSNP
rs74017183 532 dbSNP
rs1469351386 544 dbSNP
rs980109501 558 dbSNP
rs1033224061 559 dbSNP
rs1177044297 561 dbSNP
rs1481350559 562 dbSNP
rs774356848 567 dbSNP
rs987292119 569 dbSNP
rs1185651785 570 dbSNP
rs1475547357 572 dbSNP
rs539042050 573 dbSNP
rs966573517 579 dbSNP
rs1460456172 596 dbSNP
rs1395289805 606 dbSNP
rs549395492 619 dbSNP
rs191540547 620 dbSNP
rs913375471 626 dbSNP
rs1272745980 635 dbSNP
rs1307812253 654 dbSNP
rs990730511 655 dbSNP
rs1364421522 656 dbSNP
rs944891838 657 dbSNP
rs1452069255 664 dbSNP
rs1236028798 666 dbSNP
rs1256279661 668 dbSNP
rs538548183 672 dbSNP
rs975840989 673 dbSNP
rs921711070 674 dbSNP
rs1200202003 675 dbSNP
rs1276971176 676 dbSNP
rs1046603581 679 dbSNP
rs1181349523 713 dbSNP
rs1243256678 723 dbSNP
rs554839254 723 dbSNP
rs16952172 724 dbSNP
rs1037147359 726 dbSNP
rs898638268 728 dbSNP
rs1205710049 736 dbSNP
rs1218971381 752 dbSNP
rs1289981753 776 dbSNP
rs16945071 778 dbSNP
rs1049970377 786 dbSNP
rs1317267441 793 dbSNP
rs1437965541 797 dbSNP
rs1201249014 798 dbSNP
rs554299502 804 dbSNP
rs1465751610 810 dbSNP
rs1170535482 826 dbSNP
rs1402203961 829 dbSNP
rs1356086976 834 dbSNP
rs1161400457 836 dbSNP
rs1423612651 838 dbSNP
rs1385410582 843 dbSNP
rs1164996902 848 dbSNP
rs1416786870 849 dbSNP
rs1008227020 851 dbSNP
rs1466074341 852 dbSNP
rs575816692 858 dbSNP
rs1267216497 862 dbSNP
rs1222134415 875 dbSNP
rs546202794 880 dbSNP
rs1294206937 882 dbSNP
rs1237031527 890 dbSNP
rs1316393526 892 dbSNP
rs1307738022 896 dbSNP
rs896302580 898 dbSNP
rs879612713 900 dbSNP
rs1301081218 901 dbSNP
rs1404096772 907 dbSNP
rs1013866553 922 dbSNP
rs1024388010 932 dbSNP
rs1388054322 934 dbSNP
rs562886214 936 dbSNP
rs1451112586 939 dbSNP
rs1362740392 945 dbSNP
rs966772871 955 dbSNP
rs576228319 957 dbSNP
rs545565392 962 dbSNP
rs1230621669 982 dbSNP
rs1199228211 1000 dbSNP
rs957820554 1005 dbSNP
rs1480947910 1026 dbSNP
rs1032942300 1028 dbSNP
rs957383751 1030 dbSNP
rs1261581881 1047 dbSNP
rs1203638269 1056 dbSNP
rs1485644389 1077 dbSNP
rs1261394734 1087 dbSNP
rs989003216 1092 dbSNP
rs1020982587 1095 dbSNP
rs1331213642 1100 dbSNP
rs1281295096 1107 dbSNP
rs966228446 1112 dbSNP
rs1345936965 1115 dbSNP
rs1199804913 1117 dbSNP
rs976694674 1120 dbSNP
rs542107196 1130 dbSNP
rs931684791 1131 dbSNP
rs1211672542 1132 dbSNP
rs1268164446 1147 dbSNP
rs916491677 1151 dbSNP
rs1454886680 1154 dbSNP
rs1176313716 1159 dbSNP
rs544446899 1166 dbSNP
rs1247095348 1180 dbSNP
rs1431948000 1182 dbSNP
rs1191402835 1185 dbSNP
rs1428158570 1188 dbSNP
rs970837138 1192 dbSNP
rs981780830 1214 dbSNP
rs561688684 1218 dbSNP
rs940457308 1226 dbSNP
rs1202991923 1227 dbSNP
rs1197110269 1228 dbSNP
rs1257553401 1231 dbSNP
rs1037388897 1238 dbSNP
rs1425492180 1240 dbSNP
rs1478054717 1248 dbSNP
rs920096254 1251 dbSNP
rs140229567 1256 dbSNP
rs1295804324 1257 dbSNP
rs984551075 1265 dbSNP
rs908856038 1268 dbSNP
rs1050470400 1269 dbSNP
rs1470593280 1273 dbSNP
rs547234882 1284 dbSNP
rs1166579513 1301 dbSNP
rs1036269332 1309 dbSNP
rs896428362 1310 dbSNP
rs1041080204 1316 dbSNP
rs1279760714 1325 dbSNP
rs759008878 1326 dbSNP
rs563819249 1332 dbSNP
rs1184222397 1352 dbSNP
rs999614582 1354 dbSNP
rs1219675511 1361 dbSNP
rs1277998002 1375 dbSNP
rs563866683 1376 dbSNP
rs752169918 1387 dbSNP
rs957893565 1390 dbSNP
rs1230204943 1391 dbSNP
rs1313757356 1396 dbSNP
rs1452713886 1407 dbSNP
rs1342852933 1415 dbSNP
rs571040223 1417 dbSNP
rs905044145 1419 dbSNP
rs1488232011 1426 dbSNP
rs1012076343 1436 dbSNP
rs1208268817 1439 dbSNP
rs1265670151 1440 dbSNP
rs532899927 1448 dbSNP
rs549334577 1451 dbSNP
rs368553747 1461 dbSNP
rs907564817 1462 dbSNP
rs1370168090 1463 dbSNP
rs183364552 1466 dbSNP
rs16945073 1467 dbSNP
rs1020531577 1471 dbSNP
rs1206961727 1478 dbSNP
rs1489755159 1493 dbSNP
rs756892494 1495 dbSNP
rs1290575888 1497 dbSNP
rs1299616272 1498 dbSNP
rs1246129373 1499 dbSNP
rs1357824049 1499 dbSNP
rs1277216782 1500 dbSNP
rs548873245 1505 dbSNP
rs966656170 1508 dbSNP
rs997785340 1511 dbSNP
rs1049908822 1512 dbSNP
rs79157685 1513 dbSNP
rs1297900425 1514 dbSNP
rs1407242381 1524 dbSNP
rs911351910 1531 dbSNP
rs1158003794 1534 dbSNP
rs780783567 1544 dbSNP
rs1398293615 1547 dbSNP
rs984521682 1552 dbSNP
rs1184160382 1562 dbSNP
rs1479317115 1569 dbSNP
rs1314128440 1581 dbSNP
rs1267796003 1582 dbSNP
rs1222799473 1583 dbSNP
rs1452907288 1589 dbSNP
rs1189220477 1601 dbSNP
rs1321167973 1602 dbSNP
rs908990816 1603 dbSNP
rs1281542566 1604 dbSNP
rs1204019814 1606 dbSNP
rs1243825557 1610 dbSNP
rs1041281182 1617 dbSNP
rs961699544 1617 dbSNP
rs534390527 1625 dbSNP
rs972181304 1626 dbSNP
rs1354616766 1628 dbSNP
rs1438888534 1636 dbSNP
rs902526432 1643 dbSNP
rs935313227 1644 dbSNP
rs917596062 1645 dbSNP
rs893870282 1649 dbSNP
rs1012521381 1651 dbSNP
rs1468123331 1653 dbSNP
rs1428376092 1655 dbSNP
rs1191493798 1656 dbSNP
rs554440347 1658 dbSNP
rs1023479529 1668 dbSNP
rs906334535 1674 dbSNP
rs949295404 1684 dbSNP
rs1014760465 1688 dbSNP
rs1045003395 1696 dbSNP
rs1202356569 1699 dbSNP
rs1323372843 1703 dbSNP
rs961720374 1707 dbSNP
rs570922562 1718 dbSNP
rs539961268 1728 dbSNP
rs539884551 1729 dbSNP
rs1431639980 1736 dbSNP
rs936535794 1740 dbSNP
rs986262077 1741 dbSNP
rs1450373536 1746 dbSNP
rs1405247343 1755 dbSNP
rs374282150 1781 dbSNP
rs1176606912 1791 dbSNP
rs911399936 1796 dbSNP
rs893259275 1799 dbSNP
rs944170583 1805 dbSNP
rs977038064 1808 dbSNP
rs1449652867 1821 dbSNP
rs1010323627 1851 dbSNP
rs576391898 1854 dbSNP
rs140529644 1871 dbSNP
rs71143979 1871 dbSNP
rs765905699 1873 dbSNP
rs1238555241 1874 dbSNP
rs76939114 1875 dbSNP
rs60331838 1876 dbSNP
rs1306106097 1892 dbSNP
rs901855635 1893 dbSNP
rs998152628 1896 dbSNP
rs1422017342 1907 dbSNP
rs192308390 1918 dbSNP
rs1313081177 1934 dbSNP
rs1245330263 1941 dbSNP
rs1381996259 1960 dbSNP
rs1303336130 1967 dbSNP
rs1159880763 1969 dbSNP
rs1380391175 1970 dbSNP
rs1418712809 1971 dbSNP
rs1156520805 1972 dbSNP
rs1343783506 1975 dbSNP
rs1053772105 1976 dbSNP
rs1327858119 1976 dbSNP
rs1430014190 1976 dbSNP
rs57955308 1976 dbSNP
rs796783353 1976 dbSNP
rs1415218714 1979 dbSNP
rs1184135293 1985 dbSNP
rs893768578 1990 dbSNP
rs1232669964 1991 dbSNP
rs1045516141 1992 dbSNP
rs948178733 1992 dbSNP
rs1289822717 1997 dbSNP
rs755744225 2003 dbSNP
rs1360280826 2007 dbSNP
rs1029273328 2010 dbSNP
rs1451118071 2013 dbSNP
rs1314888622 2024 dbSNP
rs1229962772 2033 dbSNP
rs1371015083 2038 dbSNP
rs1278801811 2041 dbSNP
rs1311464355 2042 dbSNP
rs1377825109 2043 dbSNP
rs1300884086 2048 dbSNP
rs953514713 2052 dbSNP
rs1006429129 2070 dbSNP
rs1016020124 2076 dbSNP
rs961754060 2082 dbSNP
rs1166207121 2085 dbSNP
rs971850231 2094 dbSNP
rs1357998190 2097 dbSNP
rs1407886115 2103 dbSNP
rs144371676 2113 dbSNP
rs897734267 2123 dbSNP
rs1267149953 2124 dbSNP
rs183275747 2135 dbSNP
rs1313705859 2138 dbSNP
rs1267314392 2142 dbSNP
rs994684469 2147 dbSNP
rs1315129632 2153 dbSNP
rs769131772 2157 dbSNP
rs772786390 2159 dbSNP
rs970439596 2165 dbSNP
rs981081757 2183 dbSNP
rs1267397318 2187 dbSNP
rs926575114 2191 dbSNP
rs1255215643 2201 dbSNP
rs936503050 2204 dbSNP
rs985908272 2205 dbSNP
rs1403960711 2210 dbSNP
rs1367800868 2214 dbSNP
rs1294843541 2224 dbSNP
rs1238238694 2226 dbSNP
rs1450953980 2231 dbSNP
rs1345168685 2236 dbSNP
rs1160580771 2242 dbSNP
rs563957514 2245 dbSNP
rs1427639707 2251 dbSNP
rs74946402 2255 dbSNP
rs186531692 2260 dbSNP
rs946092810 2265 dbSNP
rs770947442 2266 dbSNP
rs901823452 2269 dbSNP
rs1414708552 2271 dbSNP
rs1268803675 2273 dbSNP
rs1331048474 2275 dbSNP
rs924215895 2275 dbSNP
rs1177173364 2276 dbSNP
rs933366315 2280 dbSNP
rs1358956546 2284 dbSNP
rs774254356 2287 dbSNP
rs532838514 2290 dbSNP
rs1006483188 2295 dbSNP
rs1380120439 2309 dbSNP
rs1363866963 2314 dbSNP
rs117481636 2317 dbSNP
rs1401098914 2319 dbSNP
rs1446187478 2327 dbSNP
rs898008213 2332 dbSNP
rs1176239397 2343 dbSNP
rs993631347 2351 dbSNP
rs1369941280 2358 dbSNP
rs1220047891 2359 dbSNP
rs368949946 2361 dbSNP
rs778891324 2373 dbSNP
rs1168638256 2377 dbSNP
rs1428101083 2387 dbSNP
rs1024752937 2389 dbSNP
rs1190529812 2407 dbSNP
rs772010767 2424 dbSNP
rs1045185400 2429 dbSNP
rs928035899 2433 dbSNP
rs1321229034 2443 dbSNP
rs1199708922 2446 dbSNP
rs970789891 2450 dbSNP
rs1200429723 2451 dbSNP
rs1036166843 2456 dbSNP
rs897640804 2457 dbSNP
rs1340943302 2458 dbSNP
rs980499105 2459 dbSNP
rs776935976 2475 dbSNP
rs1229964886 2481 dbSNP
rs1381277931 2501 dbSNP
rs1258674279 2510 dbSNP
rs957915473 2512 dbSNP
rs1404843036 2535 dbSNP
rs1296743408 2540 dbSNP
rs1461684672 2541 dbSNP
rs1391005366 2544 dbSNP
rs1170639495 2548 dbSNP
rs1049418305 2550 dbSNP
rs888823964 2551 dbSNP
rs1186787900 2567 dbSNP
rs1007637307 2569 dbSNP
rs762098762 2572 dbSNP
rs1193840342 2588 dbSNP
rs563098234 2599 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000566029.1 | 3UTR | AUUUACAGAUCAAAACUCAGCAAUAAUUUGGGCAGCUAAUGAAUGUCAUGAAAGCUGUAGAAUCUACAUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA -0.681 0 -0.684 0 14 Click to see details
KIRP -0.478 0.01 -0.488 0.01 22 Click to see details
CHOL -0.698 0.03 -0.738 0.02 8 Click to see details
PAAD -0.901 0.05 -0.800 0.1 4 Click to see details
THCA 0.274 0.08 0.422 0.01 29 Click to see details
UCEC -0.344 0.1 -0.521 0.02 15 Click to see details
HNSC -0.206 0.11 -0.115 0.25 37 Click to see details
KIRC -0.159 0.23 -0.069 0.37 24 Click to see details
LUSC -0.072 0.34 -0.178 0.15 35 Click to see details
STAD -0.078 0.34 -0.152 0.21 30 Click to see details
ESCA -0.15 0.36 -0.048 0.46 8 Click to see details
PRAD -0.057 0.37 0.000 0.5 36 Click to see details
BRCA 0.04 0.37 0.059 0.32 68 Click to see details
LIHC -0.045 0.38 -0.044 0.38 47 Click to see details
COAD -0.137 0.38 0.143 0.38 7 Click to see details
PCPG -0.323 0.4 -0.500 0.33 3 Click to see details
LUAD 0.085 0.42 0.071 0.43 8 Click to see details
KICH 0.05 0.42 0.020 0.47 17 Click to see details
KICH 0.05 0.42 0.020 0.47 17 Click to see details
KICH 0.05 0.42 0.020 0.47 17 Click to see details
KICH 0.05 0.42 0.020 0.47 17 Click to see details
75 hsa-miR-433-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT001201 GRB2 growth factor receptor bound protein 2 3 1
MIRT001741 FGF20 fibroblast growth factor 20 3 1
MIRT007225 RUNX2 runt related transcription factor 2 1 1
MIRT007361 CFTR cystic fibrosis transmembrane conductance regulator 1 1
MIRT016630 HDAC6 histone deacetylase 6 1 1
MIRT053561 KRAS KRAS proto-oncogene, GTPase 3 1
MIRT082022 COX6B1 cytochrome c oxidase subunit 6B1 2 4
MIRT086929 CREB1 cAMP responsive element binding protein 1 3 1
MIRT096407 C5ORF22 chromosome 5 open reading frame 22 2 2
MIRT135569 SPRYD4 SPRY domain containing 4 2 2
MIRT143520 CHD9 chromodomain helicase DNA binding protein 9 2 2
MIRT167706 HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2 8
MIRT207568 STARD7 StAR related lipid transfer domain containing 7 2 4
MIRT252052 WDR45B WD repeat domain 45B 2 2
MIRT327787 YIPF6 Yip1 domain family member 6 2 2
MIRT406144 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT437355 GBP2 guanylate binding protein 2 3 1
MIRT438242 TYMS thymidylate synthetase 3 1
MIRT438553 AZIN1 antizyme inhibitor 1 4 1
MIRT444186 SCAMP1 secretory carrier membrane protein 1 2 2
MIRT477737 EDN1 endothelin 1 2 2
MIRT483052 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT485778 ATXN1 ataxin 1 2 2
MIRT498142 FKBP1C FK506 binding protein 1C 2 4
MIRT499050 SSC5D scavenger receptor cysteine rich family member with 5 domains 2 8
MIRT501959 MAPK8 mitogen-activated protein kinase 8 2 2
MIRT503281 TMEM229B transmembrane protein 229B 2 4
MIRT503597 ZNF780A zinc finger protein 780A 2 2
MIRT504577 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 4
MIRT506727 LONRF2 LON peptidase N-terminal domain and ring finger 2 2 2
MIRT523130 HSP90B1 heat shock protein 90 beta family member 1 2 4
MIRT531338 TGIF2LX TGFB induced factor homeobox 2 like, X-linked 2 2
MIRT534928 PTPLAD1 3-hydroxyacyl-CoA dehydratase 3 1 1
MIRT536233 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 2
MIRT537092 GPR135 G protein-coupled receptor 135 2 2
MIRT548286 FAM3C family with sequence similarity 3 member C 2 4
MIRT549143 BRWD1 bromodomain and WD repeat domain containing 1 2 2
MIRT556354 MAFK MAF bZIP transcription factor K 2 2
MIRT557839 FKBP1A FK506 binding protein 1A 2 2
MIRT564080 NSA2 NSA2, ribosome biogenesis homolog 2 2
MIRT566382 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT573110 ERBB2IP erbb2 interacting protein 2 2
MIRT574403 TFAP2A transcription factor AP-2 alpha 2 2
MIRT576063 Poteg POTE ankyrin domain family, member G 2 2
MIRT619449 TCF20 transcription factor 20 2 2
MIRT632928 FGF9 fibroblast growth factor 9 2 2
MIRT633216 ZNF584 zinc finger protein 584 2 2
MIRT633654 SLC28A1 solute carrier family 28 member 1 2 2
MIRT637198 KLHL4 kelch like family member 4 2 2
MIRT646480 SPATS2L spermatogenesis associated serine rich 2 like 2 2
MIRT648314 SCNN1G sodium channel epithelial 1 gamma subunit 2 2
MIRT648631 LEMD2 LEM domain containing 2 2 2
MIRT655902 NEK9 NIMA related kinase 9 2 2
MIRT667805 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT675464 NUBPL nucleotide binding protein like 2 2
MIRT675974 FAM126B family with sequence similarity 126 member B 2 2
MIRT676145 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT676895 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT677459 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677533 TM4SF5 transmembrane 4 L six family member 5 2 2
MIRT677641 HAUS2 HAUS augmin like complex subunit 2 2 2
MIRT678806 HRH4 histamine receptor H4 2 2
MIRT679693 SLC1A5 solute carrier family 1 member 5 2 4
MIRT679707 RPL24 ribosomal protein L24 2 2
MIRT698822 STK38 serine/threonine kinase 38 2 2
MIRT701796 MRPS25 mitochondrial ribosomal protein S25 2 2
MIRT702220 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT706095 ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 2 2
MIRT706502 MTMR9 myotubularin related protein 9 2 2
MIRT709780 NINJ1 ninjurin 1 2 2
MIRT713859 MBNL1 muscleblind like splicing regulator 1 2 2
MIRT715807 BBS2 Bardet-Biedl syndrome 2 2 2
MIRT724229 DGKE diacylglycerol kinase epsilon 2 2
MIRT731338 MET MET proto-oncogene, receptor tyrosine kinase 1 1
MIRT731849 HIF1A hypoxia inducible factor 1 alpha subunit 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-433 ACTH approved 16132265 Microarray adrenal gland 22128032 2012 down-regulated
miR-433 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-433 Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-433-3p Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-433-3p Paclitaxel 36314 NSC125973 approved resistant Low Serous Epithelial Ovarian Cancer cell line (A2780)
hsa-miR-433-3p Fluorouracil 3385 NSC19893 approved sensitive Low Cervical Cancer cell line (Hela)
hsa-miR-433-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-433-3p Paclitaxel 36314 NSC125973 approved resistant Low Ovarian Cancer cell line (A2780, PEO1, PEO4)
hsa-miR-433-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer tissue
hsa-miR-433-3p Aromatase Inhibitor resistant Low Breast Cancer cell line (MCF-7)
hsa-miR-433-3p Temozolomide 5394 NSC362856 approved sensitive Low Glioma cell line (U251, U87)
hsa-miR-433-3p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-433-3p Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-433-3p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-433-3p Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-433-3p Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (MGC803)
hsa-miR-433-3p Gemcitabine 60750 NSC613327 approved resistant Low Pancreatic Ductal Adenocarcinoma tissue
hsa-miR-433-3p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-433-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-433-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-433-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-433-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-433-3p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-433-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-433-3p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-433-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-433-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-433-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-433-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-433-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-433-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-433-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-433-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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