miRTarBase - #MIRT153687


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pre-miRNA Information
pre-miRNA hsa-mir-137   
Genomic Coordinates chr1: 98046070 - 98046171
Description Homo sapiens miR-137 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-137
Sequence 59| UUAUUGCUUAAGAAUACGCGUAG |81
Evidence Experimental
Experiments Cloned
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B41RDC miR-137 Safety Biomarker (SAF) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol NCOA3   
Synonyms ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP
Description nuclear receptor coactivator 3
Transcript NM_001174087   
Other Transcripts NM_001174088 , NM_006534 , NM_181659   
Expression
Putative miRNA Targets on NCOA3
3'UTR of NCOA3
(miRNA target sites are highlighted)		 
>NCOA3|NM_001174087|3'UTR
   1 CATCTCTGCACCAGGACCTCTTAAGGAAACCACTGTACAAATGACACTGCACTAGGATTATTGGGAAGGAATCATTGTTC
  81 CAGGCATCCATCTTGGAAGAAAGGACCAGCTTTGAGCTCCATCAAGGGTATTTTAAGTGATGTCATTTGAGCAGGACTGG
 161 ATTTTAAGCCGAAGGGCAATATCTACGTGTTTTTCCCCCCTCCTTCTGCTGTGTATCATGGTGTTCAAAACAGAAATGTT
 241 TTTTGGCATTCCACCTCCTAGGGATATAATTCTGGAGACATGGAGTGTTACTGATCATAAAACTTTTGTGTCACTTTTTT
 321 CTGCCTTGCTAGCCAAAATCTCTTAAATACACGTAGGTGGGCCAGAGAACATTGGAAGAATCAAGAGAGATTAGAATATC
 401 TGGTTTCTCTAGTTGCAGTATTGGACAAAGAGCATAGTCCCAGCCTTCAGGTGTAGTAGTTCTGTGTTGACCCTTTGTCC
 481 AGTGGAATTGGTGATTCTGAATTGTCCTTTACTAATGGTGTTGAGTTGCTCTGTCCCTATTATTTGCCCTAGGCTTTCTC
 561 CTAATGAAGGTTTTCATTTGCCATTCATGTCCTGTAATACTTCACCTCCAGGAACTGTCATGGATGTCCAAATGGCTTTG
 641 CAGAAAGGAAATGAGATGACAGTATTTAATCGCAGCAGTAGCAAACTTTTCACATGCTAATGTGCAGCTGAGTGCACTTT
 721 ATTTAAAAAGAATGGATAAATGCAATATTCTTGAGGTCTTGAGGGAATAGTGAAACACATTCCTGGTTTTTGCCTACACT
 801 TACGTGTTAGACAAGAACTATGATTTTTTTTTTTAAAGTACTGGTGTCACCCTTTGCCTATATGGTAGAGCAATAATGCT
 881 TTTTAAAAATAAACTTCTGAAAACCCAAGGCCAGGTACTGCATTCTGAATCAGAATCTCGCAGTGTTTCTGTGAATAGAT
 961 TTTTTTGTAAATATGACCTTTAAGATATTGTATTATGTAAAATATGTATATACCTTTTTTTGTAGGTCACAACAACTCAT
1041 TTTTACAGAGTTTGTGAAGCTAAATATTTAACATTGTTGATTTCAGTAAGCTGTGTGGTGAGGCTACCAGTGGAAGAGAC
1121 ATCCCTTGACTTTTGTGGCCTGGGGGAGGGGTAGTGCTCCACAGCTTTTCCTTCCCCACCCCCCAGCCTTAGATGCCTCG
1201 CTCTTTTCAATCTCTTAATCTAAATGCTTTTTAAAGAGATTATTTGTTTAGATGTAGGCATTTTAATTTTTTAAAAATTC
1281 CTCTACCAGAACTAAGCACTTTGTTAATTTGGGGGGAAAGAATAGATATGGGGAAATAAACTTAAAAAAAAATCAGGAAT
1361 TTAAAAAAACGAGCAATTTGAAGAGAATCTTTTGGATTTTAAGCAGTCCGAAATAATAGCAATTCATGGGCTGTGTGTGT
1441 GTGTGTATGTGTGTGTGTGTGTGTGTATGTTTAATTATGTTACCTTTTCATCCCCTTTAGGAGCGTTTTCAGATTTTGGT
1521 TGCTAAGACCTGAATCCCATATTGAGATCTCGAGTAGAATCCTTGGTGTGGTTTCTGGTGTCTGCTCAGCTGTCCCCTCA
1601 TTCTACTAATGTGATGCTTTCATTATGTCCCTGTGGATTAGAATAGTGTCAGTTATTTCTTAAGTAACTCAGTACCCAGA
1681 ACAGCCAGTTTTACTGTGATTCAGAGCCACAGTCTAACTGAGCACCTTTTAAACCCCTCCCTCTTCTGCCCCCTACCACT
1761 TTTCTGCTGTTGCCTCTCTTTGACACCTGTTTTAGTCAGTTGGGAGGAAGGGAAAAATCAAGTTTAATTCCCTTTATCTG
1841 GGTTAATTCATTTGGTTCAAATAGTTGACGGAATTGGGTTTCTGAATGTCTGTGAATTTCAGAGGTCTCTGCTAGCCTTG
1921 GTATCATTTTCTAGCAATAACTGAGAGCCAGTTAATTTTAAGAATTTCACACATTTAGCCAATCTTTCTAGATGTCTCTG
2001 AAGGTAAGATCATTTAATATCTTTGATATGCTTACGAGTAAGTGAATCCTGATTATTTCCAGACCCACCACCAGAGTGGA
2081 TCTTATTTTCAAAGCAGTATAGACAATTATGAGTTTGCCCTCTTTCCCCTACCAAGTTCAAAATATATCTAAGAAAGATT
2161 GTAAATCCGAAAACTTCCATTGTAGTGGCCTGTGCTTTTCAGATAGTATACTCTCCTGTTTGGAGACAGAGGAAGAACCA
2241 GGTCAGTCTGTCTCTTTTTCAGCTCAATTGTATCTGACCCTTCTTTAAGTTATGTGTGTGGGGAGAAATAGAATGGTGCT
2321 CTTATCTTTCTTGACTTTAAAAAAATTATTAAAAACAAAAAAAAAATAAATTTTTTTGCAATCCTTTCCTCAGACCTGGC
2401 TCCAGGCTAACTGGAAGGCAGCACTCCCTTTTTTATATAGTAGAAAAATGAAGTTTATTATAAGTTTTTATATTTTCTAC
2481 TTGTTCATTTGGTGCAAACTCAAGATTTCTTTTAATAGGTGCAGTCTTTGAGATAATTTGTTTTTACCTGTATTGCCCTT
2561 TATCTTTTTTAGGTAATTCTTTGTACTCCTGCTGTCTACCTCTCCTCACACCCCAGCACCCCCCATTTTTTCAAACCTTG
2641 GTATCTGTTGGGTGAACAGTATAATCTTTTCATCTGCTTTTAGAATGTGGGATATTTCCAGTACCTACTTTTTTTTTTTT
2721 TTTTTGCTGAATCCAAAGATATATAAATAAAATATATATATTTTATAAAGATCAGAATGATATAAAGGAGATACATGTTT
2801 CTTCCTTTAAAAAATAAACGGAAGTTACATTGTTAATGTTCATATTATGATGCCACTTTTCTAAACTGCATCTGGATTGA
2881 AAGGTGTAAATATCAATAACAGTGCTACTTAGTTATCAGTATTTAATATCTGAGGTGAGTTGGGGGTATCTATATTAGGG
2961 GTAGGGTATTACAGAAGATAATTGGCTTGATGTCCTAGAAGTTCTTTGATCCAGAGGTGGGTGCAGCTGAAAGTAAACAG
3041 AATGGATTGCCAGTTACATGTATGCCTGCCCAGTTCCCTTTTTATTTGCAGAAGCTGTGAGTTTTGTTCACAATTAGGTT
3121 CCTAGGAGCAAAACCTCAAGGATTGATTTATTGTTTTCAACTCCAAGGCACACTGTTAATAAACGAGCAGGGTGTTTTCT
3201 CTCTTCCTTTCTAATATATGGAGTTTCGAAGAATAAAATATGAGAGCAATATTTAAATTCTCAGGAATTGACTTATACTC
3281 TTGAGAATGAATTCAGTTTCAATCAAGTTTACATTATGTTGCTTAAAAAAATAGAAATTATTCTTTATCTTGCAAAGAAT
3361 TGAAACCACATGAAATGACTTATGGGGGATGGTGAGCTGTGACTGCTTTGCTGACCATTTTGGATGTCATTGTAAATAAA
3441 GGTTTCTATTTAAAATTGGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauGCGCAUA-AGAAU-UCGUUAUu 5'
             :|| ||| |  || ||||||| 
Target 5' cttTGCCTATATGGTAGAGCAATAa 3'
 852 - 876 156.00 -9.50
2 
miRNA  3' gaugcgcaUAAGAAUUCGUUAUu 5'
                  |||:|  ||||||| 
Target 5' ttggtatcATTTTCTAGCAATAa 3'
 1918 - 1940 155.00 -8.90
3 
miRNA  3' gaugcGCAUAAGA-AUUCGUUAUu 5'
               | ||||:|  |||||:|| 
Target 5' tggatCTTATTTTCAAAGCAGTAt 3'
 2077 - 2100 146.00 -7.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30154093 7 COSMIC
COSN30506284 42 COSMIC
COSN26986111 69 COSMIC
COSN30182759 82 COSMIC
COSN30163171 88 COSMIC
COSN30514214 144 COSMIC
COSN26986110 150 COSMIC
COSN21368554 153 COSMIC
COSN26439846 157 COSMIC
COSN13866098 171 COSMIC
COSN30184031 173 COSMIC
COSN30184079 175 COSMIC
COSN20116506 183 COSMIC
COSN13866100 195 COSMIC
COSN18742969 195 COSMIC
COSN13866101 196 COSMIC
COSN18716767 246 COSMIC
COSN10016884 486 COSMIC
COSN24716719 495 COSMIC
COSN31481137 762 COSMIC
COSN5134330 804 COSMIC
COSN30173914 836 COSMIC
COSN17708369 973 COSMIC
COSN26576287 1173 COSMIC
COSN31550190 1184 COSMIC
COSN16850504 1205 COSMIC
COSN30013794 1228 COSMIC
COSN31520099 1237 COSMIC
COSN31584973 1261 COSMIC
COSN1874296 1415 COSMIC
COSN1874298 1424 COSMIC
COSN27982276 1446 COSMIC
COSN15661008 1448 COSMIC
COSN20116507 1467 COSMIC
COSN27346940 1490 COSMIC
COSN1249728 1717 COSMIC
COSN17846642 1944 COSMIC
COSN15660835 1980 COSMIC
COSN31514909 2037 COSMIC
COSN4780692 2120 COSMIC
COSN31541352 2207 COSMIC
COSN26566538 2247 COSMIC
COSN31572227 2275 COSMIC
COSN31523422 2318 COSMIC
COSN31532982 2367 COSMIC
COSN31595265 2413 COSMIC
COSN20093776 2500 COSMIC
COSN31518292 2638 COSMIC
COSN26648905 2684 COSMIC
COSN26551584 2688 COSMIC
COSN27320729 2725 COSMIC
COSN20116510 2726 COSMIC
COSN20116511 2726 COSMIC
COSN31513863 2739 COSMIC
COSN8000142 2949 COSMIC
COSN27176470 3040 COSMIC
COSN20116513 3134 COSMIC
COSN31548543 3238 COSMIC
COSN30169507 3269 COSMIC
COSN31607500 3327 COSMIC
COSN31609680 3358 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1193277936 4 dbSNP
rs545763445 14 dbSNP
rs372774941 16 dbSNP
rs779126997 17 dbSNP
rs1382279568 24 dbSNP
rs1288982007 29 dbSNP
rs1420362270 30 dbSNP
rs1163223942 32 dbSNP
rs72646207 41 dbSNP
rs754765634 44 dbSNP
rs1475776467 46 dbSNP
rs781170022 50 dbSNP
rs748096633 51 dbSNP
rs72646208 62 dbSNP
rs1186437620 67 dbSNP
rs1482927503 75 dbSNP
rs1251993528 77 dbSNP
rs1206825435 104 dbSNP
rs942247115 111 dbSNP
rs1036651258 113 dbSNP
rs1257714900 128 dbSNP
rs897994321 129 dbSNP
rs1468481628 131 dbSNP
rs1355916391 147 dbSNP
rs1302009745 152 dbSNP
rs1394225286 153 dbSNP
rs1377761287 157 dbSNP
rs1298274273 166 dbSNP
rs773241577 170 dbSNP
rs575463833 171 dbSNP
rs915248108 172 dbSNP
rs889219876 175 dbSNP
rs1007949716 177 dbSNP
rs1163239296 178 dbSNP
rs3092324 179 dbSNP
rs397839606 179 dbSNP
rs1339188286 180 dbSNP
rs978746126 180 dbSNP
rs3092417 186 dbSNP
rs6094766 187 dbSNP
rs1055319558 190 dbSNP
rs894869050 191 dbSNP
rs930389147 194 dbSNP
rs1009429764 195 dbSNP
rs572909502 196 dbSNP
rs886105835 197 dbSNP
rs1004588244 200 dbSNP
rs541654693 201 dbSNP
rs1441213796 204 dbSNP
rs1292121954 206 dbSNP
rs1397075046 206 dbSNP
rs1486407839 211 dbSNP
rs981925551 216 dbSNP
rs77034911 245 dbSNP
rs189567471 254 dbSNP
rs1379772811 255 dbSNP
rs984306949 260 dbSNP
rs576879510 264 dbSNP
rs143376484 267 dbSNP
rs1271193301 271 dbSNP
rs989525593 273 dbSNP
rs1261178003 275 dbSNP
rs1431613215 285 dbSNP
rs1350808694 287 dbSNP
rs181330239 288 dbSNP
rs1234441789 291 dbSNP
rs961073420 292 dbSNP
rs1372678699 293 dbSNP
rs1298826363 295 dbSNP
rs1386552997 297 dbSNP
rs1386154599 300 dbSNP
rs1291080250 302 dbSNP
rs756904105 305 dbSNP
rs1418442698 306 dbSNP
rs1292345133 307 dbSNP
rs374835226 313 dbSNP
rs1455688174 315 dbSNP
rs919516314 316 dbSNP
rs1198436724 317 dbSNP
rs1376116155 317 dbSNP
rs933445793 324 dbSNP
rs978145414 329 dbSNP
rs1051955117 335 dbSNP
rs1218638218 337 dbSNP
rs1487252994 340 dbSNP
rs1285267452 342 dbSNP
rs1210977672 349 dbSNP
rs1346585257 352 dbSNP
rs147170444 353 dbSNP
rs961001788 354 dbSNP
rs548567147 357 dbSNP
rs1298219774 363 dbSNP
rs139500644 368 dbSNP
rs1054312038 373 dbSNP
rs1340418546 376 dbSNP
rs1436596473 383 dbSNP
rs930839196 383 dbSNP
rs893804066 385 dbSNP
rs1009532830 389 dbSNP
rs1400161625 409 dbSNP
rs548508082 410 dbSNP
rs1359806947 425 dbSNP
rs1048836015 427 dbSNP
rs1405531991 429 dbSNP
rs1375048318 434 dbSNP
rs749939730 437 dbSNP
rs1476754840 452 dbSNP
rs1262375887 454 dbSNP
rs1188592116 460 dbSNP
rs1343123979 464 dbSNP
rs1443578353 465 dbSNP
rs560394083 474 dbSNP
rs72646209 485 dbSNP
rs879917843 486 dbSNP
rs1307272511 487 dbSNP
rs1199478765 495 dbSNP
rs1318424830 506 dbSNP
rs1339635509 506 dbSNP
rs1259636264 508 dbSNP
rs779718716 509 dbSNP
rs940334366 513 dbSNP
rs1241610026 515 dbSNP
rs866447867 517 dbSNP
rs1040056072 518 dbSNP
rs552306036 520 dbSNP
rs1294369548 527 dbSNP
rs1417195361 530 dbSNP
rs1338723239 533 dbSNP
rs1353580628 538 dbSNP
rs1033505507 547 dbSNP
rs115501901 548 dbSNP
rs1005299988 549 dbSNP
rs1271077549 554 dbSNP
rs1398898459 565 dbSNP
rs1487553630 571 dbSNP
rs1017098504 572 dbSNP
rs1463817566 581 dbSNP
rs1422663596 587 dbSNP
rs45610642 590 dbSNP
rs892968721 595 dbSNP
rs1421163940 596 dbSNP
rs1186186808 598 dbSNP
rs1437974642 606 dbSNP
rs1176517126 608 dbSNP
rs1011397103 611 dbSNP
rs769064038 622 dbSNP
rs1425171070 630 dbSNP
rs1165412600 650 dbSNP
rs1274220797 651 dbSNP
rs972404146 672 dbSNP
rs919485341 673 dbSNP
rs557576342 675 dbSNP
rs1456968661 677 dbSNP
rs1239840072 680 dbSNP
rs1379232110 680 dbSNP
rs781595793 701 dbSNP
rs550293555 705 dbSNP
rs1446364366 710 dbSNP
rs1399217998 720 dbSNP
rs1326309672 721 dbSNP
rs1406918970 723 dbSNP
rs1035036337 731 dbSNP
rs954923385 735 dbSNP
rs1444177379 736 dbSNP
rs113935223 738 dbSNP
rs1381656185 739 dbSNP
rs961208034 740 dbSNP
rs757628463 743 dbSNP
rs1438667251 744 dbSNP
rs1307482558 746 dbSNP
rs1450298477 747 dbSNP
rs991069450 753 dbSNP
rs988156270 754 dbSNP
rs910710310 766 dbSNP
rs1247276367 780 dbSNP
rs748498017 781 dbSNP
rs1307207578 796 dbSNP
rs1320510570 802 dbSNP
rs1371964086 804 dbSNP
rs569112996 805 dbSNP
rs536435823 808 dbSNP
rs185024445 816 dbSNP
rs573073843 819 dbSNP
rs1322768735 824 dbSNP
rs1347905913 824 dbSNP
rs984982259 824 dbSNP
rs915341513 829 dbSNP
rs1252012997 836 dbSNP
rs1438608962 844 dbSNP
rs907596234 845 dbSNP
rs1481721352 851 dbSNP
rs945357995 855 dbSNP
rs1246525394 859 dbSNP
rs1042353320 861 dbSNP
rs940462763 864 dbSNP
rs1489546459 865 dbSNP
rs35259021 867 dbSNP
rs770047112 868 dbSNP
rs1392114693 871 dbSNP
rs1431533159 872 dbSNP
rs1166711223 873 dbSNP
rs1217720784 875 dbSNP
rs1365164547 885 dbSNP
rs1274005388 904 dbSNP
rs552539526 905 dbSNP
rs1445027461 907 dbSNP
rs1003454568 912 dbSNP
rs1342283630 913 dbSNP
rs773481223 915 dbSNP
rs1411521581 916 dbSNP
rs570651593 917 dbSNP
rs573895935 919 dbSNP
rs369028562 936 dbSNP
rs558275694 940 dbSNP
rs763174545 941 dbSNP
rs144538511 950 dbSNP
rs544019069 956 dbSNP
rs1011346280 957 dbSNP
rs994415873 959 dbSNP
rs1041565841 960 dbSNP
rs1486016748 978 dbSNP
rs542919435 989 dbSNP
rs1218994612 991 dbSNP
rs1319752132 997 dbSNP
rs1276148729 999 dbSNP
rs999620425 1004 dbSNP
rs149248173 1007 dbSNP
rs1304061125 1009 dbSNP
rs993941943 1010 dbSNP
rs1029317555 1012 dbSNP
rs1445229333 1013 dbSNP
rs1358214168 1014 dbSNP
rs551088645 1015 dbSNP
rs955056863 1015 dbSNP
rs1286379510 1023 dbSNP
rs1377587872 1024 dbSNP
rs1228293001 1028 dbSNP
rs1296336158 1029 dbSNP
rs371819589 1033 dbSNP
rs1170529861 1047 dbSNP
rs960690091 1070 dbSNP
rs1416640472 1075 dbSNP
rs148491872 1090 dbSNP
rs542043111 1093 dbSNP
rs1482997772 1096 dbSNP
rs1233607733 1099 dbSNP
rs1200759767 1103 dbSNP
rs117360582 1107 dbSNP
rs1255947522 1110 dbSNP
rs1217840562 1114 dbSNP
rs990075664 1117 dbSNP
rs1801981 1138 dbSNP
rs1026254751 1148 dbSNP
rs1023877487 1152 dbSNP
rs888636028 1153 dbSNP
rs915436443 1173 dbSNP
rs945453042 1174 dbSNP
rs373321636 1180 dbSNP
rs546390148 1181 dbSNP
rs984926360 1182 dbSNP
rs1015099472 1183 dbSNP
rs1482865222 1184 dbSNP
rs1458796804 1185 dbSNP
rs72646210 1186 dbSNP
rs760641688 1189 dbSNP
rs895067448 1195 dbSNP
rs1420952096 1198 dbSNP
rs546430844 1200 dbSNP
rs941178368 1201 dbSNP
rs1237850680 1204 dbSNP
rs1197779328 1215 dbSNP
rs1267083161 1216 dbSNP
rs1038191981 1220 dbSNP
rs11699879 1223 dbSNP
rs1429532744 1233 dbSNP
rs993907580 1237 dbSNP
rs985782640 1240 dbSNP
rs1336521860 1243 dbSNP
rs780230593 1251 dbSNP
rs6125065 1254 dbSNP
rs1387644026 1267 dbSNP
rs1393331448 1268 dbSNP
rs550331893 1273 dbSNP
rs1289974351 1276 dbSNP
rs568544302 1286 dbSNP
rs146502858 1288 dbSNP
rs1343009795 1295 dbSNP
rs1041903432 1297 dbSNP
rs1418016987 1298 dbSNP
rs1017833056 1310 dbSNP
rs1379906259 1310 dbSNP
rs1199867717 1312 dbSNP
rs1216860862 1313 dbSNP
rs1277702205 1319 dbSNP
rs965315107 1322 dbSNP
rs903014743 1324 dbSNP
rs989721919 1330 dbSNP
rs1490156639 1335 dbSNP
rs1022414217 1336 dbSNP
rs1218147533 1337 dbSNP
rs1276187300 1337 dbSNP
rs966888505 1343 dbSNP
rs1056541396 1344 dbSNP
rs202154300 1344 dbSNP
rs1333138477 1345 dbSNP
rs978108178 1348 dbSNP
rs77268998 1353 dbSNP
rs928061466 1354 dbSNP
rs939339322 1363 dbSNP
rs1311401897 1364 dbSNP
rs1398165521 1368 dbSNP
rs1359987312 1370 dbSNP
rs72646211 1371 dbSNP
rs1015629989 1372 dbSNP
rs1173687330 1380 dbSNP
rs1480020184 1384 dbSNP
rs1487298778 1386 dbSNP
rs1195754427 1388 dbSNP
rs566617812 1402 dbSNP
rs941262648 1410 dbSNP
rs1200586625 1413 dbSNP
rs1346650135 1417 dbSNP
rs1038327388 1419 dbSNP
rs1269025245 1423 dbSNP
rs896986398 1425 dbSNP
rs11699902 1427 dbSNP
rs1398730417 1429 dbSNP
rs1187638177 1432 dbSNP
rs1372475120 1432 dbSNP
rs1400318871 1432 dbSNP
rs1424105917 1432 dbSNP
rs1443703430 1432 dbSNP
rs1476785961 1432 dbSNP
rs372177830 1432 dbSNP
rs914242484 1432 dbSNP
rs947094058 1432 dbSNP
rs953150679 1432 dbSNP
rs985726703 1432 dbSNP
rs1423421623 1433 dbSNP
rs1202645091 1434 dbSNP
rs1260421480 1434 dbSNP
rs1458464982 1434 dbSNP
rs1217239831 1436 dbSNP
rs1414259187 1438 dbSNP
rs1160364507 1440 dbSNP
rs1050796390 1442 dbSNP
rs924553242 1444 dbSNP
rs938511926 1444 dbSNP
rs1362982598 1445 dbSNP
rs1057380172 1446 dbSNP
rs1447820832 1446 dbSNP
rs6094767 1446 dbSNP
rs11473242 1448 dbSNP
rs144164627 1448 dbSNP
rs6090710 1448 dbSNP
rs769156345 1448 dbSNP
rs775674695 1448 dbSNP
rs896545709 1448 dbSNP
rs1182548533 1450 dbSNP
rs948124053 1454 dbSNP
rs1045046167 1466 dbSNP
rs371110073 1468 dbSNP
rs1245348896 1494 dbSNP
rs1398743965 1502 dbSNP
rs1006665803 1505 dbSNP
rs765141394 1506 dbSNP
rs575492858 1510 dbSNP
rs1273301351 1513 dbSNP
rs181794078 1514 dbSNP
rs1379393021 1519 dbSNP
rs868681788 1524 dbSNP
rs72646212 1527 dbSNP
rs997670486 1532 dbSNP
rs750033522 1537 dbSNP
rs1030469862 1541 dbSNP
rs1022506838 1552 dbSNP
rs191666426 1553 dbSNP
rs539104635 1557 dbSNP
rs1291806241 1569 dbSNP
rs1381714938 1573 dbSNP
rs1490700608 1582 dbSNP
rs1469911239 1584 dbSNP
rs537428355 1585 dbSNP
rs1247675604 1590 dbSNP
rs1035086461 1606 dbSNP
rs1201523556 1608 dbSNP
rs961055304 1609 dbSNP
rs990948272 1613 dbSNP
rs555715361 1622 dbSNP
rs1291777041 1623 dbSNP
rs557748651 1637 dbSNP
rs1245758185 1644 dbSNP
rs977516612 1650 dbSNP
rs1284071541 1651 dbSNP
rs916561162 1661 dbSNP
rs1223460893 1663 dbSNP
rs772734287 1665 dbSNP
rs962741746 1669 dbSNP
rs1275199521 1671 dbSNP
rs1470337007 1673 dbSNP
rs1178110372 1676 dbSNP
rs973944500 1680 dbSNP
rs918513463 1683 dbSNP
rs992644235 1683 dbSNP
rs915748401 1690 dbSNP
rs1382591343 1691 dbSNP
rs1418359888 1692 dbSNP
rs929765692 1692 dbSNP
rs1045164314 1695 dbSNP
rs1050899616 1699 dbSNP
rs1268730872 1700 dbSNP
rs942022355 1702 dbSNP
rs1366197029 1724 dbSNP
rs1489289579 1726 dbSNP
rs1261157256 1740 dbSNP
rs1215220885 1753 dbSNP
rs1407146546 1754 dbSNP
rs1321729910 1756 dbSNP
rs1321151517 1761 dbSNP
rs1330715705 1768 dbSNP
rs1282509502 1777 dbSNP
rs747964542 1794 dbSNP
rs1342344111 1798 dbSNP
rs1443256849 1799 dbSNP
rs865784783 1801 dbSNP
rs1359369566 1811 dbSNP
rs942438936 1815 dbSNP
rs998178997 1818 dbSNP
rs1039497950 1825 dbSNP
rs1171953899 1825 dbSNP
rs1479078352 1839 dbSNP
rs1422161638 1841 dbSNP
rs1052007232 1856 dbSNP
rs892754967 1857 dbSNP
rs574211941 1861 dbSNP
rs1208318710 1869 dbSNP
rs183437441 1870 dbSNP
rs541484234 1871 dbSNP
rs554077156 1873 dbSNP
rs187155333 1875 dbSNP
rs755476740 1879 dbSNP
rs1438010684 1881 dbSNP
rs772800423 1887 dbSNP
rs6094768 1890 dbSNP
rs1213418971 1891 dbSNP
rs1031763929 1896 dbSNP
rs1285551742 1908 dbSNP
rs1450042004 1910 dbSNP
rs959942004 1912 dbSNP
rs1178481315 1917 dbSNP
rs960938305 1940 dbSNP
rs1353259009 1943 dbSNP
rs1170363580 1949 dbSNP
rs796834693 1952 dbSNP
rs1416074632 1972 dbSNP
rs1181873240 1976 dbSNP
rs1161500038 1978 dbSNP
rs1444202891 1979 dbSNP
rs72646213 1983 dbSNP
rs1410697952 1984 dbSNP
rs1333631217 1988 dbSNP
rs1023720249 1994 dbSNP
rs983977189 2005 dbSNP
rs377697437 2010 dbSNP
rs962666812 2013 dbSNP
rs974081697 2018 dbSNP
rs1321747417 2019 dbSNP
rs942123636 2025 dbSNP
rs918616364 2031 dbSNP
rs1309609079 2032 dbSNP
rs371320520 2036 dbSNP
rs919248540 2054 dbSNP
rs531636287 2061 dbSNP
rs1458843259 2064 dbSNP
rs2664536 2070 dbSNP
rs1424159617 2071 dbSNP
rs942551961 2075 dbSNP
rs562025450 2086 dbSNP
rs1051951666 2087 dbSNP
rs529414116 2088 dbSNP
rs144185862 2097 dbSNP
rs1457085186 2107 dbSNP
rs1488751203 2111 dbSNP
rs1248455782 2117 dbSNP
rs1219607784 2118 dbSNP
rs1007656654 2129 dbSNP
rs1043216868 2130 dbSNP
rs1241897652 2133 dbSNP
rs914341346 2140 dbSNP
rs1444595285 2147 dbSNP
rs868787472 2152 dbSNP
rs1306693206 2156 dbSNP
rs947031719 2157 dbSNP
rs1387775765 2160 dbSNP
rs563905180 2169 dbSNP
rs1447774877 2170 dbSNP
rs3746480 2170 dbSNP
rs1404338462 2179 dbSNP
rs1041345196 2181 dbSNP
rs778114954 2182 dbSNP
rs999724442 2188 dbSNP
rs566594346 2189 dbSNP
rs1056756261 2200 dbSNP
rs896607477 2203 dbSNP
rs1363483692 2212 dbSNP
rs1012424554 2214 dbSNP
rs527468366 2215 dbSNP
rs898599465 2216 dbSNP
rs1431280106 2228 dbSNP
rs1433619712 2228 dbSNP
rs552218307 2229 dbSNP
rs1490028691 2232 dbSNP
rs14189 2234 dbSNP
rs895466180 2240 dbSNP
rs12273 2242 dbSNP
rs1022871730 2255 dbSNP
rs987083001 2255 dbSNP
rs1314312724 2256 dbSNP
rs1019537678 2268 dbSNP
rs1404117102 2271 dbSNP
rs964192221 2273 dbSNP
rs770906149 2275 dbSNP
rs1300082428 2279 dbSNP
rs1384513972 2285 dbSNP
rs1333438341 2286 dbSNP
rs1431186559 2291 dbSNP
rs975292230 2291 dbSNP
rs1174055572 2293 dbSNP
rs1480049457 2309 dbSNP
rs1401289433 2310 dbSNP
rs1017187874 2314 dbSNP
rs1426231727 2318 dbSNP
rs963456262 2320 dbSNP
rs972550136 2322 dbSNP
rs569753342 2323 dbSNP
rs1316883010 2324 dbSNP
rs914430891 2330 dbSNP
rs1256905246 2336 dbSNP
rs1347596286 2339 dbSNP
rs555750290 2345 dbSNP
rs1256060668 2346 dbSNP
rs1225263610 2348 dbSNP
rs977172767 2350 dbSNP
rs1313643667 2351 dbSNP
rs1397980771 2357 dbSNP
rs1404231493 2357 dbSNP
rs1469153188 2357 dbSNP
rs72646214 2357 dbSNP
rs910774182 2357 dbSNP
rs943629379 2361 dbSNP
rs1195897880 2365 dbSNP
rs1043165799 2367 dbSNP
rs1372024819 2368 dbSNP
rs904689597 2368 dbSNP
rs924275737 2370 dbSNP
rs1261165594 2371 dbSNP
rs938363778 2371 dbSNP
rs1240960388 2377 dbSNP
rs1183356885 2382 dbSNP
rs1053268805 2385 dbSNP
rs1275645576 2391 dbSNP
rs533048404 2392 dbSNP
rs774386129 2398 dbSNP
rs563500321 2409 dbSNP
rs896747286 2420 dbSNP
rs948195702 2423 dbSNP
rs2179591 2424 dbSNP
rs536607011 2426 dbSNP
rs11547289 2428 dbSNP
rs1377402668 2434 dbSNP
rs1421479414 2436 dbSNP
rs1408119960 2438 dbSNP
rs776375537 2450 dbSNP
rs1016885696 2454 dbSNP
rs1426073947 2454 dbSNP
rs1382948251 2461 dbSNP
rs572585213 2461 dbSNP
rs1234936040 2462 dbSNP
rs1180153506 2464 dbSNP
rs1339301971 2469 dbSNP
rs540001036 2470 dbSNP
rs151069803 2471 dbSNP
rs887075009 2472 dbSNP
rs1357374339 2475 dbSNP
rs774931456 2480 dbSNP
rs1329061205 2484 dbSNP
rs186687440 2489 dbSNP
rs1019928067 2493 dbSNP
rs963977525 2500 dbSNP
rs954804398 2504 dbSNP
rs1439836220 2509 dbSNP
rs1335082838 2510 dbSNP
rs975763553 2514 dbSNP
rs987396849 2517 dbSNP
rs1363206600 2520 dbSNP
rs1255814047 2521 dbSNP
rs910553419 2525 dbSNP
rs775936812 2546 dbSNP
rs1419892023 2548 dbSNP
rs943410137 2551 dbSNP
rs761819268 2555 dbSNP
rs1469956970 2558 dbSNP
rs979418762 2558 dbSNP
rs926256910 2561 dbSNP
rs1021404071 2562 dbSNP
rs1202265896 2565 dbSNP
rs1489865567 2565 dbSNP
rs140978561 2573 dbSNP
rs968560162 2574 dbSNP
rs977099015 2579 dbSNP
rs1448954114 2589 dbSNP
rs924372228 2594 dbSNP
rs1283906895 2597 dbSNP
rs1221800932 2599 dbSNP
rs1349697172 2600 dbSNP
rs1283807881 2601 dbSNP
rs938317718 2608 dbSNP
rs934808667 2613 dbSNP
rs191502116 2614 dbSNP
rs1457095526 2618 dbSNP
rs200283719 2619 dbSNP
rs1315789698 2620 dbSNP
rs1269724581 2621 dbSNP
rs1403383307 2626 dbSNP
rs915584545 2626 dbSNP
rs1431706949 2627 dbSNP
rs1429286501 2630 dbSNP
rs542386106 2639 dbSNP
rs765088204 2640 dbSNP
rs1421383767 2645 dbSNP
rs1156790289 2652 dbSNP
rs1359274423 2653 dbSNP
rs1457963769 2657 dbSNP
rs1294834467 2658 dbSNP
rs1388096406 2659 dbSNP
rs898625586 2662 dbSNP
rs1005251166 2665 dbSNP
rs762495908 2667 dbSNP
rs1300960464 2670 dbSNP
rs1214574157 2674 dbSNP
rs574077498 2677 dbSNP
rs1363491007 2687 dbSNP
rs1038674047 2703 dbSNP
rs1383123427 2705 dbSNP
rs897086940 2705 dbSNP
rs978053774 2708 dbSNP
rs1185138323 2709 dbSNP
rs1320859949 2709 dbSNP
rs1459815944 2709 dbSNP
rs1468622969 2709 dbSNP
rs200394945 2709 dbSNP
rs377097381 2709 dbSNP
rs57501886 2709 dbSNP
rs878969991 2709 dbSNP
rs1242869620 2710 dbSNP
rs1307708774 2712 dbSNP
rs1353696880 2717 dbSNP
rs1262388021 2725 dbSNP
rs1205161811 2726 dbSNP
rs1222373012 2727 dbSNP
rs1267340431 2729 dbSNP
rs1487602707 2730 dbSNP
rs1213549765 2732 dbSNP
rs1209489155 2734 dbSNP
rs1238500874 2736 dbSNP
rs1316735823 2739 dbSNP
rs1441319021 2739 dbSNP
rs994377125 2739 dbSNP
rs1450825734 2743 dbSNP
rs369146528 2745 dbSNP
rs1382544588 2750 dbSNP
rs1029504412 2752 dbSNP
rs1299197690 2752 dbSNP
rs1444968178 2752 dbSNP
rs931477107 2754 dbSNP
rs954751002 2756 dbSNP
rs1176615849 2759 dbSNP
rs1379597805 2761 dbSNP
rs1008931242 2770 dbSNP
rs1255187243 2770 dbSNP
rs1177610583 2771 dbSNP
rs1481572684 2782 dbSNP
rs1231163921 2784 dbSNP
rs72646216 2789 dbSNP
rs1359543339 2798 dbSNP
rs887210750 2804 dbSNP
rs1243351588 2809 dbSNP
rs1358351056 2817 dbSNP
rs1166242004 2818 dbSNP
rs1308124156 2820 dbSNP
rs1366228275 2820 dbSNP
rs1008754589 2821 dbSNP
rs1298106224 2821 dbSNP
rs1405585306 2827 dbSNP
rs1041040125 2839 dbSNP
rs1402112602 2841 dbSNP
rs926175987 2846 dbSNP
rs899863921 2862 dbSNP
rs996771834 2865 dbSNP
rs1364666662 2866 dbSNP
rs989352103 2870 dbSNP
rs546465696 2886 dbSNP
rs750268774 2897 dbSNP
rs1181405432 2898 dbSNP
rs1270389562 2899 dbSNP
rs1490357336 2899 dbSNP
rs1219674168 2903 dbSNP
rs998658546 2912 dbSNP
rs559777692 2913 dbSNP
rs1260957120 2919 dbSNP
rs1218299445 2943 dbSNP
rs950236642 2947 dbSNP
rs1306849704 2953 dbSNP
rs1044156398 2955 dbSNP
rs1347977598 2963 dbSNP
rs1376767242 2966 dbSNP
rs1031359242 2970 dbSNP
rs927052273 2973 dbSNP
rs1229424091 2978 dbSNP
rs1314877030 2980 dbSNP
rs1320009112 2983 dbSNP
rs1290860742 2989 dbSNP
rs1455118482 2991 dbSNP
rs1343240210 2994 dbSNP
rs940999911 2998 dbSNP
rs959797228 3003 dbSNP
rs533242267 3005 dbSNP
rs1431447688 3009 dbSNP
rs993022417 3016 dbSNP
rs531226007 3021 dbSNP
rs1459304000 3033 dbSNP
rs1196501772 3035 dbSNP
rs1237376948 3039 dbSNP
rs1483510002 3041 dbSNP
rs1206548523 3047 dbSNP
rs552159715 3048 dbSNP
rs559959730 3049 dbSNP
rs183904698 3054 dbSNP
rs1267860909 3059 dbSNP
rs1204783095 3064 dbSNP
rs1410903018 3066 dbSNP
rs377183055 3067 dbSNP
rs564087473 3070 dbSNP
rs1222911723 3072 dbSNP
rs1170847995 3078 dbSNP
rs531505941 3079 dbSNP
rs920190736 3082 dbSNP
rs1168926962 3104 dbSNP
rs1361579153 3105 dbSNP
rs931447624 3114 dbSNP
rs1407675240 3119 dbSNP
rs1051490444 3124 dbSNP
rs398088140 3130 dbSNP
rs72646217 3130 dbSNP
rs1174219844 3138 dbSNP
rs1373127577 3141 dbSNP
rs1465062702 3141 dbSNP
rs1194743004 3142 dbSNP
rs1426362455 3144 dbSNP
rs1247090936 3146 dbSNP
rs1449319824 3148 dbSNP
rs890948179 3150 dbSNP
rs1241795340 3151 dbSNP
rs1200409955 3152 dbSNP
rs1340746884 3156 dbSNP
rs72646218 3161 dbSNP
rs775655794 3165 dbSNP
rs1377713817 3173 dbSNP
rs908734217 3173 dbSNP
rs528584384 3174 dbSNP
rs1017626953 3175 dbSNP
rs1453044378 3176 dbSNP
rs567759784 3185 dbSNP
rs1334499270 3189 dbSNP
rs944127393 3191 dbSNP
rs1395349873 3193 dbSNP
rs1397208302 3194 dbSNP
rs878897617 3197 dbSNP
rs1169130418 3198 dbSNP
rs764033983 3206 dbSNP
rs1414231945 3207 dbSNP
rs762676016 3212 dbSNP
rs1278970042 3217 dbSNP
rs1446774365 3228 dbSNP
rs565949716 3228 dbSNP
rs899790581 3229 dbSNP
rs996807686 3232 dbSNP
rs1438898312 3235 dbSNP
rs1253359648 3236 dbSNP
rs72646219 3261 dbSNP
rs150254333 3263 dbSNP
rs1292709328 3274 dbSNP
rs1357604386 3277 dbSNP
rs1257130537 3279 dbSNP
rs989075568 3282 dbSNP
rs1330818265 3283 dbSNP
rs1312563774 3284 dbSNP
rs1389135192 3285 dbSNP
rs147713754 3292 dbSNP
rs998751820 3295 dbSNP
rs539126815 3298 dbSNP
rs1303285677 3299 dbSNP
rs1031452496 3302 dbSNP
rs1482916538 3305 dbSNP
rs1383074183 3315 dbSNP
rs368883109 3325 dbSNP
rs980284275 3325 dbSNP
rs1193723105 3330 dbSNP
rs1013966965 3332 dbSNP
rs1023145328 3333 dbSNP
rs969721965 3336 dbSNP
rs941125973 3337 dbSNP
rs1269655407 3341 dbSNP
rs1419167146 3341 dbSNP
rs1489916820 3344 dbSNP
rs973085987 3344 dbSNP
rs1415397966 3345 dbSNP
rs1178761416 3346 dbSNP
rs1351170848 3347 dbSNP
rs1357905735 3354 dbSNP
rs1434684408 3358 dbSNP
rs920283730 3361 dbSNP
rs576659945 3370 dbSNP
rs1283364062 3371 dbSNP
rs766172246 3372 dbSNP
rs984490713 3373 dbSNP
rs1347699529 3376 dbSNP
rs1322485229 3380 dbSNP
rs1387561434 3384 dbSNP
rs908706658 3384 dbSNP
rs1398314235 3386 dbSNP
rs944204709 3388 dbSNP
rs1472547363 3397 dbSNP
rs751071676 3400 dbSNP
rs1479499700 3405 dbSNP
rs754501609 3406 dbSNP
rs932630944 3408 dbSNP
rs1194197247 3425 dbSNP
rs138887927 3430 dbSNP
rs1286052073 3431 dbSNP
rs1043019925 3433 dbSNP
rs1347013892 3437 dbSNP
rs1217271034 3447 dbSNP
rs1287462113 3449 dbSNP
rs1263682273 3451 dbSNP
rs1224748075 3452 dbSNP
rs1364900021 3452 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions MCF7 , T47D , BT474
Location of target site 3'UTR
Tools used in this research TargetScan
Original Description (Extracted from the article) ... We also identified 3 putative miR-137 binding sites in the SRC3 3-UTR as responsible for the capacity of miR-137 to potently deplete SRC3 expression. ...

- Eedunuri VK; Rajapakshe K; Fiskus W; Geng et al., 2015, Molecular endocrinology (Baltimore, Md.).

Article - Eedunuri VK; Rajapakshe K; Fiskus W; Geng et al.
- Molecular endocrinology (Baltimore, Md.), 2015
The p160 family of steroid receptor coactivators (SRCs) are pleiotropic transcription factor coactivators and "master regulators" of gene expression that promote cancer cell proliferation, survival, metabolism, migration, invasion, and metastasis. Cancers with high p160 SRC expression exhibit poor clinical outcomes and resistance to therapy, highlighting the SRCs as critical oncogenic drivers and, thus, therapeutic targets. microRNAs are important epigenetic regulators of protein expression. To examine the regulation of p160 SRCs by microRNAs, we used and combined 4 prediction algorithms to identify microRNAs that could target SRC1, SRC2, and SRC3 expression. For validation of these predictions, we assessed p160 SRC protein expression and cell viability after transfection of corresponding microRNA mimetics in breast cancer, uveal melanoma, and prostate cancer (PC) cell lines. Transfection of selected microRNA mimetics into breast cancer, uveal melanoma, and PC cells depleted SRC protein expression levels and exerted potent antiproliferative activity in these cell types. In particular, microRNA-137 (miR-137) depleted expression of SRC1, SRC2, and very potently, SRC3. The latter effect can be attributed to the presence of 3 miR-137 recognition sequences within the SRC3 3'-untranslated region. Using reverse phase protein array analysis, we identified a network of proteins, in addition to SRC3, that were modulated by miR-137 in PC cells. We also found that miR-137 and its host gene are epigenetically silenced in human cancer specimens and cell lines. These results support the development and testing of microRNA-based therapies (in particular based on restoring miR-137 levels) for targeting the oncogenic family of p160 SRCs in cancer.
LinkOut: [PMID: 26066330]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_181659 | 3UTR | CUCUUCCUUUCUAAUAUAUGGAGUUUCGAAGAAUAAAAUAUGAGAGCAAUAUUUAAAUUCUCAGGAAUUGACUUAUACUCUUGAGAAUGAAUUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_181659 | 3UTR | AGCAAUAUUUAAAUUCUCAGGAAUUGACUUAUACUCUUGAGAAUGAAUUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_181659 | 3UTR | AGCAAUAUUUAAAUUCUCAGGAAUUGACUUAUACUCUUGAGAAUGAAUUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000341724.6 | 3UTR | CAAUAUUUAAAUUCUCAGGAAUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.843 1.5e-4 0.786 7.2e-4 13 Click to see details
GSE14794 Lymphoblastoid cells 0.209 2.4e-2 0.193 3.4e-2 90 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.389 2.7e-2 0.287 8.2e-2 25 Click to see details
GSE26953 Aortic valvular endothelial cells -0.383 3.2e-2 -0.203 1.7e-1 24 Click to see details
GSE38226 Liver fibrosis 0.382 4.4e-2 0.055 4.1e-1 21 Click to see details
GSE27834 Pluripotent stem cells -0.377 7.5e-2 -0.268 1.6e-1 16 Click to see details
GSE21687 Ependynoma primary tumors -0.177 8.1e-2 -0.002 4.9e-1 64 Click to see details
GSE28544 Breast cancer 0.268 1.0e-1 0.376 3.5e-2 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.254 1.2e-1 -0.269 1.1e-1 23 Click to see details
GSE21849 B cell lymphoma 0.18 1.8e-1 0.232 1.1e-1 29 Click to see details
GSE19350 CNS germ cell tumors 0.288 1.8e-1 0.364 1.2e-1 12 Click to see details
GSE32688 Pancreatic cancer 0.157 2.0e-1 0.245 8.8e-2 32 Click to see details
GSE17498 Multiple myeloma -0.089 2.9e-1 -0.095 2.8e-1 40 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.018 4.7e-1 -0.227 1.7e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.018 4.7e-1 -0.227 1.7e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.018 4.7e-1 -0.227 1.7e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.018 4.7e-1 -0.227 1.7e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.809 0.03 0.486 0.16 6 Click to see details
CHOL -0.895 0.05 -1.000 0.5 4 Click to see details
KICH 0.83 0.09 1.000 0.5 4 Click to see details
PAAD -0.82 0.09 -0.800 0.1 4 Click to see details
HNSC -0.175 0.18 -0.118 0.27 29 Click to see details
STAD -0.269 0.19 -0.209 0.25 13 Click to see details
KIRP 0.271 0.26 0.429 0.14 8 Click to see details
PCPG -0.652 0.27 -0.500 0.33 3 Click to see details
BLCA -0.353 0.32 -0.400 0.3 4 Click to see details
LIHC 0.481 0.34 0.500 0.33 3 Click to see details
THCA 0.081 0.34 0.090 0.33 27 Click to see details
PRAD 0.085 0.35 0.128 0.28 24 Click to see details
ESCA -0.242 0.38 -0.200 0.4 4 Click to see details
UCEC -0.188 0.41 -0.600 0.2 4 Click to see details
LUSC -0.074 0.44 -0.143 0.38 7 Click to see details
LUSC -0.074 0.44 -0.143 0.38 7 Click to see details
LUSC -0.074 0.44 -0.143 0.38 7 Click to see details
LUSC -0.074 0.44 -0.143 0.38 7 Click to see details
140 hsa-miR-137 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT002489 E2F6 E2F transcription factor 6 4 1
MIRT002490 CDK6 cyclin dependent kinase 6 4 7
MIRT004004 NCOA2 nuclear receptor coactivator 2 4 1
MIRT004579 KDM1A lysine demethylase 1A 5 3
MIRT005485 CDC42 cell division cycle 42 4 4
MIRT005605 CTBP1 C-terminal binding protein 1 4 1
MIRT005883 MITF melanogenesis associated transcription factor 3 1
MIRT006329 PTGS2 prostaglandin-endoperoxide synthase 2 2 1
MIRT006957 ESRRA estrogen related receptor alpha 1 1
MIRT007068 ZNF804A zinc finger protein 804A 1 1
MIRT007092 YBX1 Y-box binding protein 1 3 3
MIRT007252 CSE1L chromosome segregation 1 like 2 1
MIRT007346 PXN paxillin 3 1
MIRT053056 GLIPR1 GLI pathogenesis related 1 3 1
MIRT053225 MET MET proto-oncogene, receptor tyrosine kinase 3 1
MIRT054547 FUNDC1 FUN14 domain containing 1 3 1
MIRT054568 BNIP3L BCL2 interacting protein 3 like 3 1
MIRT090615 PLS1 plastin 1 2 2
MIRT093393 TMA16 translation machinery associated 16 homolog 2 2
MIRT109230 VMA21 VMA21, vacuolar ATPase assembly factor 2 6
MIRT153687 NCOA3 nuclear receptor coactivator 3 2 2
MIRT170929 FOXK1 forkhead box K1 2 2
MIRT219251 RREB1 ras responsive element binding protein 1 2 2
MIRT259552 KLHL15 kelch like family member 15 2 4
MIRT271869 ZNF678 zinc finger protein 678 2 2
MIRT280623 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT293284 DR1 down-regulator of transcription 1 2 2
MIRT314017 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT374677 AGO4 argonaute 4, RISC catalytic component 2 2
MIRT437385 FMNL2 formin like 2 1 1
MIRT437406 RORA RAR related orphan receptor A 1 1
MIRT437423 KIT KIT proto-oncogene receptor tyrosine kinase 3 1
MIRT437424 AKT2 AKT serine/threonine kinase 2 5 4
MIRT437425 TGFB2 transforming growth factor beta 2 3 1
MIRT437804 SERPINA3 serpin family A member 3 1 1
MIRT437978 COX2 cytochrome c oxidase subunit II 3 1
MIRT438078 TRIM13 tripartite motif containing 13 4 1
MIRT438287 TBX3 T-box 3 1 1
MIRT438288 KLF4 Kruppel like factor 4 1 1
MIRT438537 MTDH metadherin 2 1
MIRT438757 Nr1i3 nuclear receptor subfamily 1, group I, member 3 2 1
MIRT442564 CCDC59 coiled-coil domain containing 59 2 2
MIRT442778 JAG1 jagged 1 2 2
MIRT444302 SREK1IP1 SREK1 interacting protein 1 2 2
MIRT446969 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT448824 FKBP1A FK506 binding protein 1A 2 4
MIRT453617 SNRPE small nuclear ribonucleoprotein polypeptide E 2 4
MIRT459217 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT463490 ZC3H11A zinc finger CCCH-type containing 11A 2 12
MIRT470084 PTGES2 prostaglandin E synthase 2 2 2
MIRT475876 H3F3C H3 histone family member 3C 2 10
MIRT475912 H3F3B H3 histone family member 3B 2 8
MIRT476669 FUT11 fucosyltransferase 11 2 10
MIRT477346 EOGT EGF domain specific O-linked N-acetylglucosamine transferase 2 4
MIRT477596 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT478367 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479111 CNN2 calponin 2 2 2
MIRT482926 CTPS2 CTP synthase 2 2 2
MIRT485083 SNRK SNF related kinase 2 12
MIRT497120 NBEAL1 neurobeachin like 1 2 2
MIRT498029 UBXN4 UBX domain protein 4 2 8
MIRT500603 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT500927 SSFA2 sperm specific antigen 2 2 8
MIRT504324 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504647 RPL9 ribosomal protein L9 2 6
MIRT506304 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508007 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510538 XKR7 XK related 7 2 2
MIRT513051 LYPD6 LY6/PLAUR domain containing 6 2 6
MIRT515223 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT519857 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520508 TRAM2 translocation associated membrane protein 2 2 6
MIRT522047 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT524479 CHRM3 cholinergic receptor muscarinic 3 2 4
MIRT526904 ZNF772 zinc finger protein 772 2 6
MIRT527862 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528601 ZNF326 zinc finger protein 326 2 2
MIRT532950 ZNF24 zinc finger protein 24 2 4
MIRT536275 LMOD2 leiomodin 2 2 2
MIRT537045 GRAMD4 GRAM domain containing 4 2 2
MIRT537124 GOLGA3 golgin A3 2 4
MIRT538884 BTBD1 BTB domain containing 1 2 2
MIRT541457 AURKA aurora kinase A 2 2
MIRT542924 HOXC8 homeobox C8 2 2
MIRT544580 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT545175 RFTN2 raftlin family member 2 2 2
MIRT545248 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT546473 SLC1A5 solute carrier family 1 member 5 2 2
MIRT547523 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT548071 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548200 FNIP1 folliculin interacting protein 1 2 2
MIRT551216 CIDEC cell death inducing DFFA like effector c 2 2
MIRT553046 USP28 ubiquitin specific peptidase 28 2 2
MIRT553875 SUPT7L SPT7 like, STAGA complex gamma subunit 2 4
MIRT554026 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554153 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554192 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT554362 SFXN5 sideroflexin 5 2 4
MIRT555349 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT555822 PAX9 paired box 9 2 2
MIRT555866 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555931 NUP43 nucleoporin 43 2 2
MIRT555993 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556429 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556582 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT557220 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT558490 DBN1 drebrin 1 2 2
MIRT560986 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562291 GLO1 glyoxalase I 2 2
MIRT564093 TLR3 toll like receptor 3 2 2
MIRT565312 TMEM41A transmembrane protein 41A 2 2
MIRT565424 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566946 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT572369 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT686211 ZNF267 zinc finger protein 267 2 2
MIRT686935 SFT2D3 SFT2 domain containing 3 2 2
MIRT687448 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT710856 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT719484 RBM27 RNA binding motif protein 27 2 2
MIRT719813 TXNDC17 thioredoxin domain containing 17 2 2
MIRT720076 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT723920 ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 2 2
MIRT731305 CUL4A cullin 4A 3 1
MIRT732128 BMP7 bone morphogenetic protein 7 2 1
MIRT732466 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3 0
MIRT732962 TNC tenascin C 1 0
MIRT734856 KDM4A lysine demethylase 4A 3 0
MIRT735625 MEF2A myocyte enhancer factor 2A 2 0
MIRT735795 IL6 interleukin 6 3 0
MIRT736333 DELE1 KIAA0141 2 0
MIRT736610 RUNX2 runt related transcription factor 2 3 0
MIRT736830 NOTCH1 notch 1 3 0
MIRT736888 KCNA2 potassium voltage-gated channel subfamily A member 2 3 0
MIRT737349 EGFR epidermal growth factor receptor 3 0
MIRT755368 GLS glutaminase 2 1
MIRT755431 SPHK2 sphingosine kinase 2 3 1
MIRT756119 USP30 ubiquitin specific peptidase 30 4 1
MIRT756144 XIAP X-linked inhibitor of apoptosis 3 1
MIRT756170 COL5A1 collagen type V alpha 1 chain 3 1
MIRT756171 FSTL1 follistatin like 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-137 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-137 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-137 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-137 Emodin NULL 3220 Quantitative real-time PCR K562 cells 23744534 2013 down-regualted
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR Glioblastoma multiforme tumors cell lines 25232498 2014 up-regualted
miR-137 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-137 Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 up-regulated
miR-137 Interleukin 13 (IL-13) NULL NULL Quantitative real-time PCR esophageal squamous cells 22453679 2012 up-regulated
miR-137 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-137 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Nicotine approved 89594 Microarray Rat adrenal pheochromocytoma PC12 cell 18845019 2009 up-regulated
miR-137 Capecitabine approved 60953 Quantitative real-time PCR rectal cancer 18695884 2008 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-mir-137 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-137 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-137 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-137 Topotecan 60699 NSC609699 approved resistant cell line (W1)

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