miRTarBase - #MIRT153921


—
pre-miRNA Information
pre-miRNA hsa-mir-4500   
Genomic Coordinates chr13: 87618665 - 87618740
Description Homo sapiens miR-4500 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4500
Sequence 54| UGAGGUAGUAGUUUCUU |70
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322800324 2 dbSNP
rs1401270256 3 dbSNP
rs1382127193 7 dbSNP
rs1156555764 9 dbSNP
rs1438864054 10 dbSNP
rs1379842540 13 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NCOA3   
Synonyms ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP
Description nuclear receptor coactivator 3
Transcript NM_001174087   
Other Transcripts NM_001174088 , NM_006534 , NM_181659   
Expression
Putative miRNA Targets on NCOA3
3'UTR of NCOA3
(miRNA target sites are highlighted)		 
>NCOA3|NM_001174087|3'UTR
   1 CATCTCTGCACCAGGACCTCTTAAGGAAACCACTGTACAAATGACACTGCACTAGGATTATTGGGAAGGAATCATTGTTC
  81 CAGGCATCCATCTTGGAAGAAAGGACCAGCTTTGAGCTCCATCAAGGGTATTTTAAGTGATGTCATTTGAGCAGGACTGG
 161 ATTTTAAGCCGAAGGGCAATATCTACGTGTTTTTCCCCCCTCCTTCTGCTGTGTATCATGGTGTTCAAAACAGAAATGTT
 241 TTTTGGCATTCCACCTCCTAGGGATATAATTCTGGAGACATGGAGTGTTACTGATCATAAAACTTTTGTGTCACTTTTTT
 321 CTGCCTTGCTAGCCAAAATCTCTTAAATACACGTAGGTGGGCCAGAGAACATTGGAAGAATCAAGAGAGATTAGAATATC
 401 TGGTTTCTCTAGTTGCAGTATTGGACAAAGAGCATAGTCCCAGCCTTCAGGTGTAGTAGTTCTGTGTTGACCCTTTGTCC
 481 AGTGGAATTGGTGATTCTGAATTGTCCTTTACTAATGGTGTTGAGTTGCTCTGTCCCTATTATTTGCCCTAGGCTTTCTC
 561 CTAATGAAGGTTTTCATTTGCCATTCATGTCCTGTAATACTTCACCTCCAGGAACTGTCATGGATGTCCAAATGGCTTTG
 641 CAGAAAGGAAATGAGATGACAGTATTTAATCGCAGCAGTAGCAAACTTTTCACATGCTAATGTGCAGCTGAGTGCACTTT
 721 ATTTAAAAAGAATGGATAAATGCAATATTCTTGAGGTCTTGAGGGAATAGTGAAACACATTCCTGGTTTTTGCCTACACT
 801 TACGTGTTAGACAAGAACTATGATTTTTTTTTTTAAAGTACTGGTGTCACCCTTTGCCTATATGGTAGAGCAATAATGCT
 881 TTTTAAAAATAAACTTCTGAAAACCCAAGGCCAGGTACTGCATTCTGAATCAGAATCTCGCAGTGTTTCTGTGAATAGAT
 961 TTTTTTGTAAATATGACCTTTAAGATATTGTATTATGTAAAATATGTATATACCTTTTTTTGTAGGTCACAACAACTCAT
1041 TTTTACAGAGTTTGTGAAGCTAAATATTTAACATTGTTGATTTCAGTAAGCTGTGTGGTGAGGCTACCAGTGGAAGAGAC
1121 ATCCCTTGACTTTTGTGGCCTGGGGGAGGGGTAGTGCTCCACAGCTTTTCCTTCCCCACCCCCCAGCCTTAGATGCCTCG
1201 CTCTTTTCAATCTCTTAATCTAAATGCTTTTTAAAGAGATTATTTGTTTAGATGTAGGCATTTTAATTTTTTAAAAATTC
1281 CTCTACCAGAACTAAGCACTTTGTTAATTTGGGGGGAAAGAATAGATATGGGGAAATAAACTTAAAAAAAAATCAGGAAT
1361 TTAAAAAAACGAGCAATTTGAAGAGAATCTTTTGGATTTTAAGCAGTCCGAAATAATAGCAATTCATGGGCTGTGTGTGT
1441 GTGTGTATGTGTGTGTGTGTGTGTGTATGTTTAATTATGTTACCTTTTCATCCCCTTTAGGAGCGTTTTCAGATTTTGGT
1521 TGCTAAGACCTGAATCCCATATTGAGATCTCGAGTAGAATCCTTGGTGTGGTTTCTGGTGTCTGCTCAGCTGTCCCCTCA
1601 TTCTACTAATGTGATGCTTTCATTATGTCCCTGTGGATTAGAATAGTGTCAGTTATTTCTTAAGTAACTCAGTACCCAGA
1681 ACAGCCAGTTTTACTGTGATTCAGAGCCACAGTCTAACTGAGCACCTTTTAAACCCCTCCCTCTTCTGCCCCCTACCACT
1761 TTTCTGCTGTTGCCTCTCTTTGACACCTGTTTTAGTCAGTTGGGAGGAAGGGAAAAATCAAGTTTAATTCCCTTTATCTG
1841 GGTTAATTCATTTGGTTCAAATAGTTGACGGAATTGGGTTTCTGAATGTCTGTGAATTTCAGAGGTCTCTGCTAGCCTTG
1921 GTATCATTTTCTAGCAATAACTGAGAGCCAGTTAATTTTAAGAATTTCACACATTTAGCCAATCTTTCTAGATGTCTCTG
2001 AAGGTAAGATCATTTAATATCTTTGATATGCTTACGAGTAAGTGAATCCTGATTATTTCCAGACCCACCACCAGAGTGGA
2081 TCTTATTTTCAAAGCAGTATAGACAATTATGAGTTTGCCCTCTTTCCCCTACCAAGTTCAAAATATATCTAAGAAAGATT
2161 GTAAATCCGAAAACTTCCATTGTAGTGGCCTGTGCTTTTCAGATAGTATACTCTCCTGTTTGGAGACAGAGGAAGAACCA
2241 GGTCAGTCTGTCTCTTTTTCAGCTCAATTGTATCTGACCCTTCTTTAAGTTATGTGTGTGGGGAGAAATAGAATGGTGCT
2321 CTTATCTTTCTTGACTTTAAAAAAATTATTAAAAACAAAAAAAAAATAAATTTTTTTGCAATCCTTTCCTCAGACCTGGC
2401 TCCAGGCTAACTGGAAGGCAGCACTCCCTTTTTTATATAGTAGAAAAATGAAGTTTATTATAAGTTTTTATATTTTCTAC
2481 TTGTTCATTTGGTGCAAACTCAAGATTTCTTTTAATAGGTGCAGTCTTTGAGATAATTTGTTTTTACCTGTATTGCCCTT
2561 TATCTTTTTTAGGTAATTCTTTGTACTCCTGCTGTCTACCTCTCCTCACACCCCAGCACCCCCCATTTTTTCAAACCTTG
2641 GTATCTGTTGGGTGAACAGTATAATCTTTTCATCTGCTTTTAGAATGTGGGATATTTCCAGTACCTACTTTTTTTTTTTT
2721 TTTTTGCTGAATCCAAAGATATATAAATAAAATATATATATTTTATAAAGATCAGAATGATATAAAGGAGATACATGTTT
2801 CTTCCTTTAAAAAATAAACGGAAGTTACATTGTTAATGTTCATATTATGATGCCACTTTTCTAAACTGCATCTGGATTGA
2881 AAGGTGTAAATATCAATAACAGTGCTACTTAGTTATCAGTATTTAATATCTGAGGTGAGTTGGGGGTATCTATATTAGGG
2961 GTAGGGTATTACAGAAGATAATTGGCTTGATGTCCTAGAAGTTCTTTGATCCAGAGGTGGGTGCAGCTGAAAGTAAACAG
3041 AATGGATTGCCAGTTACATGTATGCCTGCCCAGTTCCCTTTTTATTTGCAGAAGCTGTGAGTTTTGTTCACAATTAGGTT
3121 CCTAGGAGCAAAACCTCAAGGATTGATTTATTGTTTTCAACTCCAAGGCACACTGTTAATAAACGAGCAGGGTGTTTTCT
3201 CTCTTCCTTTCTAATATATGGAGTTTCGAAGAATAAAATATGAGAGCAATATTTAAATTCTCAGGAATTGACTTATACTC
3281 TTGAGAATGAATTCAGTTTCAATCAAGTTTACATTATGTTGCTTAAAAAAATAGAAATTATTCTTTATCTTGCAAAGAAT
3361 TGAAACCACATGAAATGACTTATGGGGGATGGTGAGCTGTGACTGCTTTGCTGACCATTTTGGATGTCATTGTAAATAAA
3441 GGTTTCTATTTAAAATTGGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uucuuUGAU-GAUGGAGu 5'
               :||: ||||||| 
Target 5' ctcctGCTGTCTACCTCt 3'
 2586 - 2603 144.00 -11.60
2 
miRNA  3' uucUUUGAUGAUGGAGu 5'
             ||||  || |||| 
Target 5' tttAAACCCCTCCCTCt 3'
 1728 - 1744 122.00 -7.20
3 
miRNA  3' uucuuUGAUGAUGGAGu 5'
               :||::|:|||| 
Target 5' tttctGCTGTTGCCTCt 3'
 1761 - 1777 120.00 -12.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30154093 7 COSMIC
COSN30506284 42 COSMIC
COSN26986111 69 COSMIC
COSN30182759 82 COSMIC
COSN30163171 88 COSMIC
COSN30514214 144 COSMIC
COSN26986110 150 COSMIC
COSN21368554 153 COSMIC
COSN26439846 157 COSMIC
COSN13866098 171 COSMIC
COSN30184031 173 COSMIC
COSN30184079 175 COSMIC
COSN20116506 183 COSMIC
COSN13866100 195 COSMIC
COSN18742969 195 COSMIC
COSN13866101 196 COSMIC
COSN18716767 246 COSMIC
COSN10016884 486 COSMIC
COSN24716719 495 COSMIC
COSN31481137 762 COSMIC
COSN5134330 804 COSMIC
COSN30173914 836 COSMIC
COSN17708369 973 COSMIC
COSN26576287 1173 COSMIC
COSN31550190 1184 COSMIC
COSN16850504 1205 COSMIC
COSN30013794 1228 COSMIC
COSN31520099 1237 COSMIC
COSN31584973 1261 COSMIC
COSN1874296 1415 COSMIC
COSN1874298 1424 COSMIC
COSN27982276 1446 COSMIC
COSN15661008 1448 COSMIC
COSN20116507 1467 COSMIC
COSN27346940 1490 COSMIC
COSN1249728 1717 COSMIC
COSN17846642 1944 COSMIC
COSN15660835 1980 COSMIC
COSN31514909 2037 COSMIC
COSN4780692 2120 COSMIC
COSN31541352 2207 COSMIC
COSN26566538 2247 COSMIC
COSN31572227 2275 COSMIC
COSN31523422 2318 COSMIC
COSN31532982 2367 COSMIC
COSN31595265 2413 COSMIC
COSN20093776 2500 COSMIC
COSN31518292 2638 COSMIC
COSN26648905 2684 COSMIC
COSN26551584 2688 COSMIC
COSN27320729 2725 COSMIC
COSN20116510 2726 COSMIC
COSN20116511 2726 COSMIC
COSN31513863 2739 COSMIC
COSN8000142 2949 COSMIC
COSN27176470 3040 COSMIC
COSN20116513 3134 COSMIC
COSN31548543 3238 COSMIC
COSN30169507 3269 COSMIC
COSN31607500 3327 COSMIC
COSN31609680 3358 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1193277936 4 dbSNP
rs545763445 14 dbSNP
rs372774941 16 dbSNP
rs779126997 17 dbSNP
rs1382279568 24 dbSNP
rs1288982007 29 dbSNP
rs1420362270 30 dbSNP
rs1163223942 32 dbSNP
rs72646207 41 dbSNP
rs754765634 44 dbSNP
rs1475776467 46 dbSNP
rs781170022 50 dbSNP
rs748096633 51 dbSNP
rs72646208 62 dbSNP
rs1186437620 67 dbSNP
rs1482927503 75 dbSNP
rs1251993528 77 dbSNP
rs1206825435 104 dbSNP
rs942247115 111 dbSNP
rs1036651258 113 dbSNP
rs1257714900 128 dbSNP
rs897994321 129 dbSNP
rs1468481628 131 dbSNP
rs1355916391 147 dbSNP
rs1302009745 152 dbSNP
rs1394225286 153 dbSNP
rs1377761287 157 dbSNP
rs1298274273 166 dbSNP
rs773241577 170 dbSNP
rs575463833 171 dbSNP
rs915248108 172 dbSNP
rs889219876 175 dbSNP
rs1007949716 177 dbSNP
rs1163239296 178 dbSNP
rs3092324 179 dbSNP
rs397839606 179 dbSNP
rs1339188286 180 dbSNP
rs978746126 180 dbSNP
rs3092417 186 dbSNP
rs6094766 187 dbSNP
rs1055319558 190 dbSNP
rs894869050 191 dbSNP
rs930389147 194 dbSNP
rs1009429764 195 dbSNP
rs572909502 196 dbSNP
rs886105835 197 dbSNP
rs1004588244 200 dbSNP
rs541654693 201 dbSNP
rs1441213796 204 dbSNP
rs1292121954 206 dbSNP
rs1397075046 206 dbSNP
rs1486407839 211 dbSNP
rs981925551 216 dbSNP
rs77034911 245 dbSNP
rs189567471 254 dbSNP
rs1379772811 255 dbSNP
rs984306949 260 dbSNP
rs576879510 264 dbSNP
rs143376484 267 dbSNP
rs1271193301 271 dbSNP
rs989525593 273 dbSNP
rs1261178003 275 dbSNP
rs1431613215 285 dbSNP
rs1350808694 287 dbSNP
rs181330239 288 dbSNP
rs1234441789 291 dbSNP
rs961073420 292 dbSNP
rs1372678699 293 dbSNP
rs1298826363 295 dbSNP
rs1386552997 297 dbSNP
rs1386154599 300 dbSNP
rs1291080250 302 dbSNP
rs756904105 305 dbSNP
rs1418442698 306 dbSNP
rs1292345133 307 dbSNP
rs374835226 313 dbSNP
rs1455688174 315 dbSNP
rs919516314 316 dbSNP
rs1198436724 317 dbSNP
rs1376116155 317 dbSNP
rs933445793 324 dbSNP
rs978145414 329 dbSNP
rs1051955117 335 dbSNP
rs1218638218 337 dbSNP
rs1487252994 340 dbSNP
rs1285267452 342 dbSNP
rs1210977672 349 dbSNP
rs1346585257 352 dbSNP
rs147170444 353 dbSNP
rs961001788 354 dbSNP
rs548567147 357 dbSNP
rs1298219774 363 dbSNP
rs139500644 368 dbSNP
rs1054312038 373 dbSNP
rs1340418546 376 dbSNP
rs1436596473 383 dbSNP
rs930839196 383 dbSNP
rs893804066 385 dbSNP
rs1009532830 389 dbSNP
rs1400161625 409 dbSNP
rs548508082 410 dbSNP
rs1359806947 425 dbSNP
rs1048836015 427 dbSNP
rs1405531991 429 dbSNP
rs1375048318 434 dbSNP
rs749939730 437 dbSNP
rs1476754840 452 dbSNP
rs1262375887 454 dbSNP
rs1188592116 460 dbSNP
rs1343123979 464 dbSNP
rs1443578353 465 dbSNP
rs560394083 474 dbSNP
rs72646209 485 dbSNP
rs879917843 486 dbSNP
rs1307272511 487 dbSNP
rs1199478765 495 dbSNP
rs1318424830 506 dbSNP
rs1339635509 506 dbSNP
rs1259636264 508 dbSNP
rs779718716 509 dbSNP
rs940334366 513 dbSNP
rs1241610026 515 dbSNP
rs866447867 517 dbSNP
rs1040056072 518 dbSNP
rs552306036 520 dbSNP
rs1294369548 527 dbSNP
rs1417195361 530 dbSNP
rs1338723239 533 dbSNP
rs1353580628 538 dbSNP
rs1033505507 547 dbSNP
rs115501901 548 dbSNP
rs1005299988 549 dbSNP
rs1271077549 554 dbSNP
rs1398898459 565 dbSNP
rs1487553630 571 dbSNP
rs1017098504 572 dbSNP
rs1463817566 581 dbSNP
rs1422663596 587 dbSNP
rs45610642 590 dbSNP
rs892968721 595 dbSNP
rs1421163940 596 dbSNP
rs1186186808 598 dbSNP
rs1437974642 606 dbSNP
rs1176517126 608 dbSNP
rs1011397103 611 dbSNP
rs769064038 622 dbSNP
rs1425171070 630 dbSNP
rs1165412600 650 dbSNP
rs1274220797 651 dbSNP
rs972404146 672 dbSNP
rs919485341 673 dbSNP
rs557576342 675 dbSNP
rs1456968661 677 dbSNP
rs1239840072 680 dbSNP
rs1379232110 680 dbSNP
rs781595793 701 dbSNP
rs550293555 705 dbSNP
rs1446364366 710 dbSNP
rs1399217998 720 dbSNP
rs1326309672 721 dbSNP
rs1406918970 723 dbSNP
rs1035036337 731 dbSNP
rs954923385 735 dbSNP
rs1444177379 736 dbSNP
rs113935223 738 dbSNP
rs1381656185 739 dbSNP
rs961208034 740 dbSNP
rs757628463 743 dbSNP
rs1438667251 744 dbSNP
rs1307482558 746 dbSNP
rs1450298477 747 dbSNP
rs991069450 753 dbSNP
rs988156270 754 dbSNP
rs910710310 766 dbSNP
rs1247276367 780 dbSNP
rs748498017 781 dbSNP
rs1307207578 796 dbSNP
rs1320510570 802 dbSNP
rs1371964086 804 dbSNP
rs569112996 805 dbSNP
rs536435823 808 dbSNP
rs185024445 816 dbSNP
rs573073843 819 dbSNP
rs1322768735 824 dbSNP
rs1347905913 824 dbSNP
rs984982259 824 dbSNP
rs915341513 829 dbSNP
rs1252012997 836 dbSNP
rs1438608962 844 dbSNP
rs907596234 845 dbSNP
rs1481721352 851 dbSNP
rs945357995 855 dbSNP
rs1246525394 859 dbSNP
rs1042353320 861 dbSNP
rs940462763 864 dbSNP
rs1489546459 865 dbSNP
rs35259021 867 dbSNP
rs770047112 868 dbSNP
rs1392114693 871 dbSNP
rs1431533159 872 dbSNP
rs1166711223 873 dbSNP
rs1217720784 875 dbSNP
rs1365164547 885 dbSNP
rs1274005388 904 dbSNP
rs552539526 905 dbSNP
rs1445027461 907 dbSNP
rs1003454568 912 dbSNP
rs1342283630 913 dbSNP
rs773481223 915 dbSNP
rs1411521581 916 dbSNP
rs570651593 917 dbSNP
rs573895935 919 dbSNP
rs369028562 936 dbSNP
rs558275694 940 dbSNP
rs763174545 941 dbSNP
rs144538511 950 dbSNP
rs544019069 956 dbSNP
rs1011346280 957 dbSNP
rs994415873 959 dbSNP
rs1041565841 960 dbSNP
rs1486016748 978 dbSNP
rs542919435 989 dbSNP
rs1218994612 991 dbSNP
rs1319752132 997 dbSNP
rs1276148729 999 dbSNP
rs999620425 1004 dbSNP
rs149248173 1007 dbSNP
rs1304061125 1009 dbSNP
rs993941943 1010 dbSNP
rs1029317555 1012 dbSNP
rs1445229333 1013 dbSNP
rs1358214168 1014 dbSNP
rs551088645 1015 dbSNP
rs955056863 1015 dbSNP
rs1286379510 1023 dbSNP
rs1377587872 1024 dbSNP
rs1228293001 1028 dbSNP
rs1296336158 1029 dbSNP
rs371819589 1033 dbSNP
rs1170529861 1047 dbSNP
rs960690091 1070 dbSNP
rs1416640472 1075 dbSNP
rs148491872 1090 dbSNP
rs542043111 1093 dbSNP
rs1482997772 1096 dbSNP
rs1233607733 1099 dbSNP
rs1200759767 1103 dbSNP
rs117360582 1107 dbSNP
rs1255947522 1110 dbSNP
rs1217840562 1114 dbSNP
rs990075664 1117 dbSNP
rs1801981 1138 dbSNP
rs1026254751 1148 dbSNP
rs1023877487 1152 dbSNP
rs888636028 1153 dbSNP
rs915436443 1173 dbSNP
rs945453042 1174 dbSNP
rs373321636 1180 dbSNP
rs546390148 1181 dbSNP
rs984926360 1182 dbSNP
rs1015099472 1183 dbSNP
rs1482865222 1184 dbSNP
rs1458796804 1185 dbSNP
rs72646210 1186 dbSNP
rs760641688 1189 dbSNP
rs895067448 1195 dbSNP
rs1420952096 1198 dbSNP
rs546430844 1200 dbSNP
rs941178368 1201 dbSNP
rs1237850680 1204 dbSNP
rs1197779328 1215 dbSNP
rs1267083161 1216 dbSNP
rs1038191981 1220 dbSNP
rs11699879 1223 dbSNP
rs1429532744 1233 dbSNP
rs993907580 1237 dbSNP
rs985782640 1240 dbSNP
rs1336521860 1243 dbSNP
rs780230593 1251 dbSNP
rs6125065 1254 dbSNP
rs1387644026 1267 dbSNP
rs1393331448 1268 dbSNP
rs550331893 1273 dbSNP
rs1289974351 1276 dbSNP
rs568544302 1286 dbSNP
rs146502858 1288 dbSNP
rs1343009795 1295 dbSNP
rs1041903432 1297 dbSNP
rs1418016987 1298 dbSNP
rs1017833056 1310 dbSNP
rs1379906259 1310 dbSNP
rs1199867717 1312 dbSNP
rs1216860862 1313 dbSNP
rs1277702205 1319 dbSNP
rs965315107 1322 dbSNP
rs903014743 1324 dbSNP
rs989721919 1330 dbSNP
rs1490156639 1335 dbSNP
rs1022414217 1336 dbSNP
rs1218147533 1337 dbSNP
rs1276187300 1337 dbSNP
rs966888505 1343 dbSNP
rs1056541396 1344 dbSNP
rs202154300 1344 dbSNP
rs1333138477 1345 dbSNP
rs978108178 1348 dbSNP
rs77268998 1353 dbSNP
rs928061466 1354 dbSNP
rs939339322 1363 dbSNP
rs1311401897 1364 dbSNP
rs1398165521 1368 dbSNP
rs1359987312 1370 dbSNP
rs72646211 1371 dbSNP
rs1015629989 1372 dbSNP
rs1173687330 1380 dbSNP
rs1480020184 1384 dbSNP
rs1487298778 1386 dbSNP
rs1195754427 1388 dbSNP
rs566617812 1402 dbSNP
rs941262648 1410 dbSNP
rs1200586625 1413 dbSNP
rs1346650135 1417 dbSNP
rs1038327388 1419 dbSNP
rs1269025245 1423 dbSNP
rs896986398 1425 dbSNP
rs11699902 1427 dbSNP
rs1398730417 1429 dbSNP
rs1187638177 1432 dbSNP
rs1372475120 1432 dbSNP
rs1400318871 1432 dbSNP
rs1424105917 1432 dbSNP
rs1443703430 1432 dbSNP
rs1476785961 1432 dbSNP
rs372177830 1432 dbSNP
rs914242484 1432 dbSNP
rs947094058 1432 dbSNP
rs953150679 1432 dbSNP
rs985726703 1432 dbSNP
rs1423421623 1433 dbSNP
rs1202645091 1434 dbSNP
rs1260421480 1434 dbSNP
rs1458464982 1434 dbSNP
rs1217239831 1436 dbSNP
rs1414259187 1438 dbSNP
rs1160364507 1440 dbSNP
rs1050796390 1442 dbSNP
rs924553242 1444 dbSNP
rs938511926 1444 dbSNP
rs1362982598 1445 dbSNP
rs1057380172 1446 dbSNP
rs1447820832 1446 dbSNP
rs6094767 1446 dbSNP
rs11473242 1448 dbSNP
rs144164627 1448 dbSNP
rs6090710 1448 dbSNP
rs769156345 1448 dbSNP
rs775674695 1448 dbSNP
rs896545709 1448 dbSNP
rs1182548533 1450 dbSNP
rs948124053 1454 dbSNP
rs1045046167 1466 dbSNP
rs371110073 1468 dbSNP
rs1245348896 1494 dbSNP
rs1398743965 1502 dbSNP
rs1006665803 1505 dbSNP
rs765141394 1506 dbSNP
rs575492858 1510 dbSNP
rs1273301351 1513 dbSNP
rs181794078 1514 dbSNP
rs1379393021 1519 dbSNP
rs868681788 1524 dbSNP
rs72646212 1527 dbSNP
rs997670486 1532 dbSNP
rs750033522 1537 dbSNP
rs1030469862 1541 dbSNP
rs1022506838 1552 dbSNP
rs191666426 1553 dbSNP
rs539104635 1557 dbSNP
rs1291806241 1569 dbSNP
rs1381714938 1573 dbSNP
rs1490700608 1582 dbSNP
rs1469911239 1584 dbSNP
rs537428355 1585 dbSNP
rs1247675604 1590 dbSNP
rs1035086461 1606 dbSNP
rs1201523556 1608 dbSNP
rs961055304 1609 dbSNP
rs990948272 1613 dbSNP
rs555715361 1622 dbSNP
rs1291777041 1623 dbSNP
rs557748651 1637 dbSNP
rs1245758185 1644 dbSNP
rs977516612 1650 dbSNP
rs1284071541 1651 dbSNP
rs916561162 1661 dbSNP
rs1223460893 1663 dbSNP
rs772734287 1665 dbSNP
rs962741746 1669 dbSNP
rs1275199521 1671 dbSNP
rs1470337007 1673 dbSNP
rs1178110372 1676 dbSNP
rs973944500 1680 dbSNP
rs918513463 1683 dbSNP
rs992644235 1683 dbSNP
rs915748401 1690 dbSNP
rs1382591343 1691 dbSNP
rs1418359888 1692 dbSNP
rs929765692 1692 dbSNP
rs1045164314 1695 dbSNP
rs1050899616 1699 dbSNP
rs1268730872 1700 dbSNP
rs942022355 1702 dbSNP
rs1366197029 1724 dbSNP
rs1489289579 1726 dbSNP
rs1261157256 1740 dbSNP
rs1215220885 1753 dbSNP
rs1407146546 1754 dbSNP
rs1321729910 1756 dbSNP
rs1321151517 1761 dbSNP
rs1330715705 1768 dbSNP
rs1282509502 1777 dbSNP
rs747964542 1794 dbSNP
rs1342344111 1798 dbSNP
rs1443256849 1799 dbSNP
rs865784783 1801 dbSNP
rs1359369566 1811 dbSNP
rs942438936 1815 dbSNP
rs998178997 1818 dbSNP
rs1039497950 1825 dbSNP
rs1171953899 1825 dbSNP
rs1479078352 1839 dbSNP
rs1422161638 1841 dbSNP
rs1052007232 1856 dbSNP
rs892754967 1857 dbSNP
rs574211941 1861 dbSNP
rs1208318710 1869 dbSNP
rs183437441 1870 dbSNP
rs541484234 1871 dbSNP
rs554077156 1873 dbSNP
rs187155333 1875 dbSNP
rs755476740 1879 dbSNP
rs1438010684 1881 dbSNP
rs772800423 1887 dbSNP
rs6094768 1890 dbSNP
rs1213418971 1891 dbSNP
rs1031763929 1896 dbSNP
rs1285551742 1908 dbSNP
rs1450042004 1910 dbSNP
rs959942004 1912 dbSNP
rs1178481315 1917 dbSNP
rs960938305 1940 dbSNP
rs1353259009 1943 dbSNP
rs1170363580 1949 dbSNP
rs796834693 1952 dbSNP
rs1416074632 1972 dbSNP
rs1181873240 1976 dbSNP
rs1161500038 1978 dbSNP
rs1444202891 1979 dbSNP
rs72646213 1983 dbSNP
rs1410697952 1984 dbSNP
rs1333631217 1988 dbSNP
rs1023720249 1994 dbSNP
rs983977189 2005 dbSNP
rs377697437 2010 dbSNP
rs962666812 2013 dbSNP
rs974081697 2018 dbSNP
rs1321747417 2019 dbSNP
rs942123636 2025 dbSNP
rs918616364 2031 dbSNP
rs1309609079 2032 dbSNP
rs371320520 2036 dbSNP
rs919248540 2054 dbSNP
rs531636287 2061 dbSNP
rs1458843259 2064 dbSNP
rs2664536 2070 dbSNP
rs1424159617 2071 dbSNP
rs942551961 2075 dbSNP
rs562025450 2086 dbSNP
rs1051951666 2087 dbSNP
rs529414116 2088 dbSNP
rs144185862 2097 dbSNP
rs1457085186 2107 dbSNP
rs1488751203 2111 dbSNP
rs1248455782 2117 dbSNP
rs1219607784 2118 dbSNP
rs1007656654 2129 dbSNP
rs1043216868 2130 dbSNP
rs1241897652 2133 dbSNP
rs914341346 2140 dbSNP
rs1444595285 2147 dbSNP
rs868787472 2152 dbSNP
rs1306693206 2156 dbSNP
rs947031719 2157 dbSNP
rs1387775765 2160 dbSNP
rs563905180 2169 dbSNP
rs1447774877 2170 dbSNP
rs3746480 2170 dbSNP
rs1404338462 2179 dbSNP
rs1041345196 2181 dbSNP
rs778114954 2182 dbSNP
rs999724442 2188 dbSNP
rs566594346 2189 dbSNP
rs1056756261 2200 dbSNP
rs896607477 2203 dbSNP
rs1363483692 2212 dbSNP
rs1012424554 2214 dbSNP
rs527468366 2215 dbSNP
rs898599465 2216 dbSNP
rs1431280106 2228 dbSNP
rs1433619712 2228 dbSNP
rs552218307 2229 dbSNP
rs1490028691 2232 dbSNP
rs14189 2234 dbSNP
rs895466180 2240 dbSNP
rs12273 2242 dbSNP
rs1022871730 2255 dbSNP
rs987083001 2255 dbSNP
rs1314312724 2256 dbSNP
rs1019537678 2268 dbSNP
rs1404117102 2271 dbSNP
rs964192221 2273 dbSNP
rs770906149 2275 dbSNP
rs1300082428 2279 dbSNP
rs1384513972 2285 dbSNP
rs1333438341 2286 dbSNP
rs1431186559 2291 dbSNP
rs975292230 2291 dbSNP
rs1174055572 2293 dbSNP
rs1480049457 2309 dbSNP
rs1401289433 2310 dbSNP
rs1017187874 2314 dbSNP
rs1426231727 2318 dbSNP
rs963456262 2320 dbSNP
rs972550136 2322 dbSNP
rs569753342 2323 dbSNP
rs1316883010 2324 dbSNP
rs914430891 2330 dbSNP
rs1256905246 2336 dbSNP
rs1347596286 2339 dbSNP
rs555750290 2345 dbSNP
rs1256060668 2346 dbSNP
rs1225263610 2348 dbSNP
rs977172767 2350 dbSNP
rs1313643667 2351 dbSNP
rs1397980771 2357 dbSNP
rs1404231493 2357 dbSNP
rs1469153188 2357 dbSNP
rs72646214 2357 dbSNP
rs910774182 2357 dbSNP
rs943629379 2361 dbSNP
rs1195897880 2365 dbSNP
rs1043165799 2367 dbSNP
rs1372024819 2368 dbSNP
rs904689597 2368 dbSNP
rs924275737 2370 dbSNP
rs1261165594 2371 dbSNP
rs938363778 2371 dbSNP
rs1240960388 2377 dbSNP
rs1183356885 2382 dbSNP
rs1053268805 2385 dbSNP
rs1275645576 2391 dbSNP
rs533048404 2392 dbSNP
rs774386129 2398 dbSNP
rs563500321 2409 dbSNP
rs896747286 2420 dbSNP
rs948195702 2423 dbSNP
rs2179591 2424 dbSNP
rs536607011 2426 dbSNP
rs11547289 2428 dbSNP
rs1377402668 2434 dbSNP
rs1421479414 2436 dbSNP
rs1408119960 2438 dbSNP
rs776375537 2450 dbSNP
rs1016885696 2454 dbSNP
rs1426073947 2454 dbSNP
rs1382948251 2461 dbSNP
rs572585213 2461 dbSNP
rs1234936040 2462 dbSNP
rs1180153506 2464 dbSNP
rs1339301971 2469 dbSNP
rs540001036 2470 dbSNP
rs151069803 2471 dbSNP
rs887075009 2472 dbSNP
rs1357374339 2475 dbSNP
rs774931456 2480 dbSNP
rs1329061205 2484 dbSNP
rs186687440 2489 dbSNP
rs1019928067 2493 dbSNP
rs963977525 2500 dbSNP
rs954804398 2504 dbSNP
rs1439836220 2509 dbSNP
rs1335082838 2510 dbSNP
rs975763553 2514 dbSNP
rs987396849 2517 dbSNP
rs1363206600 2520 dbSNP
rs1255814047 2521 dbSNP
rs910553419 2525 dbSNP
rs775936812 2546 dbSNP
rs1419892023 2548 dbSNP
rs943410137 2551 dbSNP
rs761819268 2555 dbSNP
rs1469956970 2558 dbSNP
rs979418762 2558 dbSNP
rs926256910 2561 dbSNP
rs1021404071 2562 dbSNP
rs1202265896 2565 dbSNP
rs1489865567 2565 dbSNP
rs140978561 2573 dbSNP
rs968560162 2574 dbSNP
rs977099015 2579 dbSNP
rs1448954114 2589 dbSNP
rs924372228 2594 dbSNP
rs1283906895 2597 dbSNP
rs1221800932 2599 dbSNP
rs1349697172 2600 dbSNP
rs1283807881 2601 dbSNP
rs938317718 2608 dbSNP
rs934808667 2613 dbSNP
rs191502116 2614 dbSNP
rs1457095526 2618 dbSNP
rs200283719 2619 dbSNP
rs1315789698 2620 dbSNP
rs1269724581 2621 dbSNP
rs1403383307 2626 dbSNP
rs915584545 2626 dbSNP
rs1431706949 2627 dbSNP
rs1429286501 2630 dbSNP
rs542386106 2639 dbSNP
rs765088204 2640 dbSNP
rs1421383767 2645 dbSNP
rs1156790289 2652 dbSNP
rs1359274423 2653 dbSNP
rs1457963769 2657 dbSNP
rs1294834467 2658 dbSNP
rs1388096406 2659 dbSNP
rs898625586 2662 dbSNP
rs1005251166 2665 dbSNP
rs762495908 2667 dbSNP
rs1300960464 2670 dbSNP
rs1214574157 2674 dbSNP
rs574077498 2677 dbSNP
rs1363491007 2687 dbSNP
rs1038674047 2703 dbSNP
rs1383123427 2705 dbSNP
rs897086940 2705 dbSNP
rs978053774 2708 dbSNP
rs1185138323 2709 dbSNP
rs1320859949 2709 dbSNP
rs1459815944 2709 dbSNP
rs1468622969 2709 dbSNP
rs200394945 2709 dbSNP
rs377097381 2709 dbSNP
rs57501886 2709 dbSNP
rs878969991 2709 dbSNP
rs1242869620 2710 dbSNP
rs1307708774 2712 dbSNP
rs1353696880 2717 dbSNP
rs1262388021 2725 dbSNP
rs1205161811 2726 dbSNP
rs1222373012 2727 dbSNP
rs1267340431 2729 dbSNP
rs1487602707 2730 dbSNP
rs1213549765 2732 dbSNP
rs1209489155 2734 dbSNP
rs1238500874 2736 dbSNP
rs1316735823 2739 dbSNP
rs1441319021 2739 dbSNP
rs994377125 2739 dbSNP
rs1450825734 2743 dbSNP
rs369146528 2745 dbSNP
rs1382544588 2750 dbSNP
rs1029504412 2752 dbSNP
rs1299197690 2752 dbSNP
rs1444968178 2752 dbSNP
rs931477107 2754 dbSNP
rs954751002 2756 dbSNP
rs1176615849 2759 dbSNP
rs1379597805 2761 dbSNP
rs1008931242 2770 dbSNP
rs1255187243 2770 dbSNP
rs1177610583 2771 dbSNP
rs1481572684 2782 dbSNP
rs1231163921 2784 dbSNP
rs72646216 2789 dbSNP
rs1359543339 2798 dbSNP
rs887210750 2804 dbSNP
rs1243351588 2809 dbSNP
rs1358351056 2817 dbSNP
rs1166242004 2818 dbSNP
rs1308124156 2820 dbSNP
rs1366228275 2820 dbSNP
rs1008754589 2821 dbSNP
rs1298106224 2821 dbSNP
rs1405585306 2827 dbSNP
rs1041040125 2839 dbSNP
rs1402112602 2841 dbSNP
rs926175987 2846 dbSNP
rs899863921 2862 dbSNP
rs996771834 2865 dbSNP
rs1364666662 2866 dbSNP
rs989352103 2870 dbSNP
rs546465696 2886 dbSNP
rs750268774 2897 dbSNP
rs1181405432 2898 dbSNP
rs1270389562 2899 dbSNP
rs1490357336 2899 dbSNP
rs1219674168 2903 dbSNP
rs998658546 2912 dbSNP
rs559777692 2913 dbSNP
rs1260957120 2919 dbSNP
rs1218299445 2943 dbSNP
rs950236642 2947 dbSNP
rs1306849704 2953 dbSNP
rs1044156398 2955 dbSNP
rs1347977598 2963 dbSNP
rs1376767242 2966 dbSNP
rs1031359242 2970 dbSNP
rs927052273 2973 dbSNP
rs1229424091 2978 dbSNP
rs1314877030 2980 dbSNP
rs1320009112 2983 dbSNP
rs1290860742 2989 dbSNP
rs1455118482 2991 dbSNP
rs1343240210 2994 dbSNP
rs940999911 2998 dbSNP
rs959797228 3003 dbSNP
rs533242267 3005 dbSNP
rs1431447688 3009 dbSNP
rs993022417 3016 dbSNP
rs531226007 3021 dbSNP
rs1459304000 3033 dbSNP
rs1196501772 3035 dbSNP
rs1237376948 3039 dbSNP
rs1483510002 3041 dbSNP
rs1206548523 3047 dbSNP
rs552159715 3048 dbSNP
rs559959730 3049 dbSNP
rs183904698 3054 dbSNP
rs1267860909 3059 dbSNP
rs1204783095 3064 dbSNP
rs1410903018 3066 dbSNP
rs377183055 3067 dbSNP
rs564087473 3070 dbSNP
rs1222911723 3072 dbSNP
rs1170847995 3078 dbSNP
rs531505941 3079 dbSNP
rs920190736 3082 dbSNP
rs1168926962 3104 dbSNP
rs1361579153 3105 dbSNP
rs931447624 3114 dbSNP
rs1407675240 3119 dbSNP
rs1051490444 3124 dbSNP
rs398088140 3130 dbSNP
rs72646217 3130 dbSNP
rs1174219844 3138 dbSNP
rs1373127577 3141 dbSNP
rs1465062702 3141 dbSNP
rs1194743004 3142 dbSNP
rs1426362455 3144 dbSNP
rs1247090936 3146 dbSNP
rs1449319824 3148 dbSNP
rs890948179 3150 dbSNP
rs1241795340 3151 dbSNP
rs1200409955 3152 dbSNP
rs1340746884 3156 dbSNP
rs72646218 3161 dbSNP
rs775655794 3165 dbSNP
rs1377713817 3173 dbSNP
rs908734217 3173 dbSNP
rs528584384 3174 dbSNP
rs1017626953 3175 dbSNP
rs1453044378 3176 dbSNP
rs567759784 3185 dbSNP
rs1334499270 3189 dbSNP
rs944127393 3191 dbSNP
rs1395349873 3193 dbSNP
rs1397208302 3194 dbSNP
rs878897617 3197 dbSNP
rs1169130418 3198 dbSNP
rs764033983 3206 dbSNP
rs1414231945 3207 dbSNP
rs762676016 3212 dbSNP
rs1278970042 3217 dbSNP
rs1446774365 3228 dbSNP
rs565949716 3228 dbSNP
rs899790581 3229 dbSNP
rs996807686 3232 dbSNP
rs1438898312 3235 dbSNP
rs1253359648 3236 dbSNP
rs72646219 3261 dbSNP
rs150254333 3263 dbSNP
rs1292709328 3274 dbSNP
rs1357604386 3277 dbSNP
rs1257130537 3279 dbSNP
rs989075568 3282 dbSNP
rs1330818265 3283 dbSNP
rs1312563774 3284 dbSNP
rs1389135192 3285 dbSNP
rs147713754 3292 dbSNP
rs998751820 3295 dbSNP
rs539126815 3298 dbSNP
rs1303285677 3299 dbSNP
rs1031452496 3302 dbSNP
rs1482916538 3305 dbSNP
rs1383074183 3315 dbSNP
rs368883109 3325 dbSNP
rs980284275 3325 dbSNP
rs1193723105 3330 dbSNP
rs1013966965 3332 dbSNP
rs1023145328 3333 dbSNP
rs969721965 3336 dbSNP
rs941125973 3337 dbSNP
rs1269655407 3341 dbSNP
rs1419167146 3341 dbSNP
rs1489916820 3344 dbSNP
rs973085987 3344 dbSNP
rs1415397966 3345 dbSNP
rs1178761416 3346 dbSNP
rs1351170848 3347 dbSNP
rs1357905735 3354 dbSNP
rs1434684408 3358 dbSNP
rs920283730 3361 dbSNP
rs576659945 3370 dbSNP
rs1283364062 3371 dbSNP
rs766172246 3372 dbSNP
rs984490713 3373 dbSNP
rs1347699529 3376 dbSNP
rs1322485229 3380 dbSNP
rs1387561434 3384 dbSNP
rs908706658 3384 dbSNP
rs1398314235 3386 dbSNP
rs944204709 3388 dbSNP
rs1472547363 3397 dbSNP
rs751071676 3400 dbSNP
rs1479499700 3405 dbSNP
rs754501609 3406 dbSNP
rs932630944 3408 dbSNP
rs1194197247 3425 dbSNP
rs138887927 3430 dbSNP
rs1286052073 3431 dbSNP
rs1043019925 3433 dbSNP
rs1347013892 3437 dbSNP
rs1217271034 3447 dbSNP
rs1287462113 3449 dbSNP
rs1263682273 3451 dbSNP
rs1224748075 3452 dbSNP
rs1364900021 3452 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uucuuUGAU-GAUGGAGu 5'
               :||: ||||||| 
Target 5' cuccuGCUGUCUACCUCu 3'
 		3 - 20
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177600. RNA binding protein: AGO2. Condition:p53_V_Ago_CLIP_2_2 PAR-CLIP data was present in ERX177606. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_8 PAR-CLIP data was present in ERX177612. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_2 PAR-CLIP data was present in ERX177613. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_3 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 PAR-CLIP data was present in ERX177625. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_3 PAR-CLIP data was present in ERX177630. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_8 PAR-CLIP data was present in ERX177633. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_11 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000341724.6 | 3UTR | UACUCCUGCUGUCUACCUCUCCUCACACCCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
278 hsa-miR-4500 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT063205 ADIPOR2 adiponectin receptor 2 2 2
MIRT065701 ESPL1 extra spindle pole bodies like 1, separase 2 4
MIRT066489 HMGA2 high mobility group AT-hook 2 2 4
MIRT067415 TMTC3 transmembrane and tetratricopeptide repeat containing 3 2 2
MIRT068169 TXLNA taxilin alpha 2 2
MIRT068540 NHLRC3 NHL repeat containing 3 2 6
MIRT068798 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT073020 ARID3B AT-rich interaction domain 3B 2 6
MIRT073683 IGF1R insulin like growth factor 1 receptor 2 8
MIRT076241 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 6
MIRT077628 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT080409 ONECUT2 one cut homeobox 2 2 2
MIRT083315 ZCCHC3 zinc finger CCHC-type containing 3 2 2
MIRT084989 BACH1 BTB domain and CNC homolog 1 2 2
MIRT094172 PCGF3 polycomb group ring finger 3 2 6
MIRT094475 SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 2 4
MIRT095781 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT100105 ABT1 activator of basal transcription 1 2 8
MIRT112254 MDM4 MDM4, p53 regulator 2 4
MIRT118595 STK4 serine/threonine kinase 4 2 2
MIRT120932 PDE12 phosphodiesterase 12 2 8
MIRT123336 CALU calumenin 2 2
MIRT123991 POLR3D RNA polymerase III subunit D 2 2
MIRT152317 TNFSF9 TNF superfamily member 9 2 2
MIRT153921 NCOA3 nuclear receptor coactivator 3 2 2
MIRT168608 HMGA1 high mobility group AT-hook 1 2 4
MIRT180614 CRY2 cryptochrome circadian clock 2 2 2
MIRT187726 SUOX sulfite oxidase 2 2
MIRT191415 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT193113 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT215732 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT218822 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT240344 UBXN2B UBX domain protein 2B 2 2
MIRT243480 TRIM71 tripartite motif containing 71 2 2
MIRT244088 EDN1 endothelin 1 2 2
MIRT252341 SALL3 spalt like transcription factor 3 2 2
MIRT255327 CDV3 CDV3 homolog 2 2
MIRT259295 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT259499 TXLNG taxilin gamma 2 2
MIRT260715 CLDN12 claudin 12 2 6
MIRT264701 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT266228 PEX11B peroxisomal biogenesis factor 11 beta 2 2
MIRT266635 CHTOP chromatin target of PRMT1 2 2
MIRT268847 C1ORF21 chromosome 1 open reading frame 21 2 2
MIRT284540 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT294453 ZNF264 zinc finger protein 264 2 2
MIRT297023 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT297451 SLC20A1 solute carrier family 20 member 1 2 4
MIRT300049 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT300907 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT303328 MXD1 MAX dimerization protein 1 2 2
MIRT309858 NAT8L N-acetyltransferase 8 like 2 2
MIRT322434 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT324742 ACER2 alkaline ceramidase 2 2 2
MIRT402068 ATP6V1F ATPase H+ transporting V1 subunit F 2 4
MIRT442014 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT445653 ATP6V1G1 ATPase H+ transporting V1 subunit G1 2 6
MIRT447131 KIF27 kinesin family member 27 2 2
MIRT448262 ZNF774 zinc finger protein 774 2 2
MIRT449002 ANKRD46 ankyrin repeat domain 46 2 2
MIRT449949 FMNL3 formin like 3 2 2
MIRT451150 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT451620 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT451689 C1RL complement C1r subcomponent like 2 2
MIRT452087 NUCB2 nucleobindin 2 2 2
MIRT452427 QDPR quinoid dihydropteridine reductase 2 2
MIRT452938 DISC1 disrupted in schizophrenia 1 2 2
MIRT453397 RHD Rh blood group D antigen 2 6
MIRT454159 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT454275 FXN frataxin 2 2
MIRT454535 RABL2A RAB, member of RAS oncogene family like 2A 2 2
MIRT454849 ACOT9 acyl-CoA thioesterase 9 2 4
MIRT455671 GLO1 glyoxalase I 2 2
MIRT457243 RABL2B RAB, member of RAS oncogene family like 2B 2 2
MIRT457671 ZNF587 zinc finger protein 587 2 2
MIRT457882 THEM6 thioesterase superfamily member 6 2 4
MIRT458012 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT458275 FUT10 fucosyltransferase 10 2 2
MIRT459732 RRM1 ribonucleotide reductase catalytic subunit M1 2 2
MIRT460447 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460495 FAM105A family with sequence similarity 105 member A 2 6
MIRT460933 NOA1 nitric oxide associated 1 2 4
MIRT461088 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT461164 SLC11A2 solute carrier family 11 member 2 2 4
MIRT461360 COL8A1 collagen type VIII alpha 1 chain 2 2
MIRT462377 YAE1D1 Yae1 domain containing 1 2 2
MIRT462775 ZNF8 zinc finger protein 8 2 2
MIRT463426 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463656 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT464260 VCL vinculin 2 2
MIRT465121 TSC22D2 TSC22 domain family member 2 2 4
MIRT466190 TMED5 transmembrane p24 trafficking protein 5 2 4
MIRT466728 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT469098 RNF144B ring finger protein 144B 2 2
MIRT469718 RAB40C RAB40C, member RAS oncogene family 2 2
MIRT470422 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT470684 POLR2D RNA polymerase II subunit D 2 4
MIRT470866 PLXND1 plexin D1 2 2
MIRT471269 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT471960 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT472677 NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 2 2
MIRT472735 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT473132 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT473237 SMCR7L mitochondrial elongation factor 1 2 5
MIRT473824 MAP2K7 mitogen-activated protein kinase kinase 7 2 2
MIRT473935 LYN LYN proto-oncogene, Src family tyrosine kinase 2 2
MIRT474020 LRRC20 leucine rich repeat containing 20 2 2
MIRT474504 KLHDC8B kelch domain containing 8B 2 2
MIRT474762 KIAA0930 KIAA0930 2 2
MIRT474912 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT475327 IFNLR1 interferon lambda receptor 1 2 2
MIRT475374 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT475729 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT476544 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT476982 FAM83G family with sequence similarity 83 member G 2 4
MIRT477539 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 2 4
MIRT477676 EFHD2 EF-hand domain family member D2 2 2
MIRT479751 CCND1 cyclin D1 2 2
MIRT481189 ATXN7L3B ataxin 7 like 3B 2 4
MIRT481235 ATXN7L3 ataxin 7 like 3 2 2
MIRT481358 ATG9A autophagy related 9A 2 2
MIRT481383 ATG12 autophagy related 12 2 2
MIRT481647 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT481843 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT482179 AHR aryl hydrocarbon receptor 2 2
MIRT482215 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT485301 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT486654 ZNF28 zinc finger protein 28 2 2
MIRT489409 TUBB2A tubulin beta 2A class IIa 2 2
MIRT491861 ZBTB5 zinc finger and BTB domain containing 5 2 8
MIRT492217 SOCS1 suppressor of cytokine signaling 1 2 2
MIRT492632 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT493320 LIMD2 LIM domain containing 2 2 2
MIRT493897 FAM43A family with sequence similarity 43 member A 2 4
MIRT494259 CEP120 centrosomal protein 120 2 2
MIRT494681 ARID3A AT-rich interaction domain 3A 2 2
MIRT495963 TBC1D19 TBC1 domain family member 19 2 2
MIRT496117 SNX17 sorting nexin 17 2 2
MIRT497870 SLC12A7 solute carrier family 12 member 7 2 2
MIRT498115 PLEKHO1 pleckstrin homology domain containing O1 2 4
MIRT499400 PLCG2 phospholipase C gamma 2 2 4
MIRT499489 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 2 2
MIRT499648 SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 2 2
MIRT499937 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT499993 HIST1H2BD histone cluster 1 H2B family member d 2 4
MIRT500821 THBS1 thrombospondin 1 2 3
MIRT500900 STRN striatin 2 4
MIRT501111 SLC5A6 solute carrier family 5 member 6 2 4
MIRT501179 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501206 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT501249 SEMA4C semaphorin 4C 2 6
MIRT501334 RNFT1 ring finger protein, transmembrane 1 2 2
MIRT501357 RNF44 ring finger protein 44 2 4
MIRT501394 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT501437 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT501749 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT501939 MBD2 methyl-CpG binding domain protein 2 2 8
MIRT502104 KPNA5 karyopherin subunit alpha 5 2 8
MIRT502123 KMT2D lysine methyltransferase 2D 2 4
MIRT502787 CEP135 centrosomal protein 135 2 2
MIRT502839 CELF1 CUGBP Elav-like family member 1 2 2
MIRT504783 C12orf4 chromosome 12 open reading frame 4 2 2
MIRT505020 ZNF644 zinc finger protein 644 2 2
MIRT505577 SMC1A structural maintenance of chromosomes 1A 2 6
MIRT506359 NUP155 nucleoporin 155 2 6
MIRT506936 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT507248 FIGN fidgetin, microtubule severing factor 2 8
MIRT507691 COIL coilin 2 6
MIRT508397 C1orf210 chromosome 1 open reading frame 210 2 6
MIRT508660 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT508927 AK4 adenylate kinase 4 2 4
MIRT510387 ZNF566 zinc finger protein 566 2 6
MIRT510521 YOD1 YOD1 deubiquitinase 2 6
MIRT511381 IKZF3 IKAROS family zinc finger 3 2 4
MIRT512740 CD59 CD59 molecule (CD59 blood group) 2 4
MIRT515949 C9orf156 tRNA methyltransferase O 2 2
MIRT516078 ZBTB8OS zinc finger and BTB domain containing 8 opposite strand 2 4
MIRT521392 RDX radixin 2 4
MIRT522344 NCKIPSD NCK interacting protein with SH3 domain 2 4
MIRT523623 FZD9 frizzled class receptor 9 2 4
MIRT523728 FBXW2 F-box and WD repeat domain containing 2 2 4
MIRT523981 DVL3 dishevelled segment polarity protein 3 2 2
MIRT524108 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT525722 SOD2 superoxide dismutase 2 2 2
MIRT527758 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT529722 OPRL1 opioid related nociceptin receptor 1 2 2
MIRT533183 WASL Wiskott-Aldrich syndrome like 2 6
MIRT536373 LEFTY1 left-right determination factor 1 2 2
MIRT543781 RBM12B RNA binding motif protein 12B 2 4
MIRT543863 SLC16A9 solute carrier family 16 member 9 2 2
MIRT545383 PM20D2 peptidase M20 domain containing 2 2 2
MIRT545895 ZNF200 zinc finger protein 200 2 4
MIRT546328 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT547374 MSI2 musashi RNA binding protein 2 2 2
MIRT547577 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT547834 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 4
MIRT548260 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT548342 EPHA4 EPH receptor A4 2 2
MIRT548539 DUSP1 dual specificity phosphatase 1 2 2
MIRT548554 DNAL1 dynein axonemal light chain 1 2 2
MIRT548787 COLEC12 collectin subfamily member 12 2 2
MIRT548976 CCNT2 cyclin T2 2 2
MIRT549026 CBX5 chromobox 5 2 2
MIRT549213 BEND4 BEN domain containing 4 2 4
MIRT549759 ZNF611 zinc finger protein 611 2 6
MIRT549794 KIAA0391 KIAA0391 2 2
MIRT549843 ECHDC1 ethylmalonyl-CoA decarboxylase 1 2 2
MIRT550723 PMPCA peptidase, mitochondrial processing alpha subunit 2 4
MIRT550893 ACTA1 actin, alpha 1, skeletal muscle 2 2
MIRT551277 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT551313 GSG2 histone H3 associated protein kinase 2 6
MIRT551928 AKAP8 A-kinase anchoring protein 8 2 4
MIRT551998 RAD18 RAD18, E3 ubiquitin protein ligase 2 2
MIRT552405 ZNF460 zinc finger protein 460 2 4
MIRT553016 USP38 ubiquitin specific peptidase 38 2 2
MIRT555544 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT555716 PDZD8 PDZ domain containing 8 2 2
MIRT557377 HAND1 heart and neural crest derivatives expressed 1 2 2
MIRT557957 FAM222B family with sequence similarity 222 member B 2 2
MIRT559086 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT559493 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT561777 PEG10 paternally expressed 10 2 2
MIRT564396 EMILIN2 elastin microfibril interfacer 2 2 4
MIRT565445 SURF4 surfeit 4 2 2
MIRT566514 PARP16 poly(ADP-ribose) polymerase family member 16 2 2
MIRT567437 GNG5 G protein subunit gamma 5 2 2
MIRT567712 E2F6 E2F transcription factor 6 2 2
MIRT568652 ABHD17C abhydrolase domain containing 17C 2 2
MIRT569493 THYN1 thymocyte nuclear protein 1 2 2
MIRT573816 TGOLN2 trans-golgi network protein 2 2 2
MIRT574358 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT574754 GOLGA4 golgin A4 2 2
MIRT574791 FAM104A family with sequence similarity 104 member A 2 2
MIRT576081 Poteg POTE ankyrin domain family, member G 2 2
MIRT576813 Thbs1 thrombospondin 1 2 3
MIRT616365 RWDD1 RWD domain containing 1 2 2
MIRT617846 FMO4 flavin containing monooxygenase 4 2 2
MIRT642389 ZNF556 zinc finger protein 556 2 2
MIRT680514 PRIM2 DNA primase subunit 2 2 2
MIRT680542 ZNF584 zinc finger protein 584 2 2
MIRT680795 ZNF578 zinc finger protein 578 2 2
MIRT680833 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT681136 INTS7 integrator complex subunit 7 2 2
MIRT681266 RFC2 replication factor C subunit 2 2 2
MIRT681318 ZFAND4 zinc finger AN1-type containing 4 2 4
MIRT681354 BRI3BP BRI3 binding protein 2 2
MIRT681501 STAT2 signal transducer and activator of transcription 2 2 2
MIRT681531 ZNF738 zinc finger protein 738 2 2
MIRT681653 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT681733 RAB19 RAB19, member RAS oncogene family 2 4
MIRT681756 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 2
MIRT681792 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681864 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT681936 SLC19A3 solute carrier family 19 member 3 2 2
MIRT682097 ITGA3 integrin subunit alpha 3 2 4
MIRT682177 SLC38A7 solute carrier family 38 member 7 2 2
MIRT682233 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682379 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682439 MTX3 metaxin 3 2 2
MIRT682599 CPA4 carboxypeptidase A4 2 2
MIRT682635 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT689323 FPR1 formyl peptide receptor 1 2 2
MIRT689725 ATXN2 ataxin 2 2 2
MIRT691031 ZNF799 zinc finger protein 799 2 2
MIRT691930 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT694879 ZNF417 zinc finger protein 417 2 2
MIRT695250 ZNF443 zinc finger protein 443 2 2
MIRT695408 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT700593 PRSS22 protease, serine 22 2 2
MIRT701434 NHLRC2 NHL repeat containing 2 2 2
MIRT702479 KIAA1328 KIAA1328 2 2
MIRT702716 IPO9 importin 9 2 2
MIRT704036 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT704415 CTPS1 CTP synthase 1 2 2
MIRT705745 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT712369 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT713515 PAFAH2 platelet activating factor acetylhydrolase 2 2 2
MIRT735773 STAT3 signal transducer and activator of transcription 3 6 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4500 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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