pre-miRNA Information
pre-miRNA hsa-mir-569   
Genomic Coordinates chr3: 171106664 - 171106759
Synonyms MIRN569, hsa-mir-569, MIR569
Description Homo sapiens miR-569 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-569
Sequence 61| AGUUAAUGAAUCCUGGAAAGU |81
Evidence Experimental
Experiments SAGE
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN23021417 4 COSMIC
COSN1083370 8 COSMIC
COSN30455038 12 COSMIC
COSN24300323 13 COSMIC
COSN32068274 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs752673293 5 dbSNP
rs1218920077 8 dbSNP
rs745722313 12 dbSNP
rs1368837885 14 dbSNP
Putative Targets

Gene Information
Gene Symbol PARD6B   
Synonyms PAR6B
Description par-6 family cell polarity regulator beta
Transcript NM_032521   
Expression
Putative miRNA Targets on PARD6B
3'UTR of PARD6B
(miRNA target sites are highlighted)
>PARD6B|NM_032521|3'UTR
   1 AACCGTGGTTTGAATGTTTTCAGAGTGAGGATGCCATGAGGACTTGTACATTTGGCTAGTTTAAAAGCATATATACCTCT
  81 GACCAGTGACGTGGAATAGGCATGAGACGAGTAACGTTGCAAGCTTACAATATTATTAAAGTAGTAGTTTGATAATTGTT
 161 AATATAAACTTTGGTGGATCAGAGGTGAATTTAAGTCCAAAACAAAGGGGCCTTTGCTGATGAAGTTACGTGCTTTTGCT
 241 GTTTTGTCTGTGGAGAATCAGATGTTAAAGCACATTCTTGGAACTATGTGAGAAGACTAGATCATTTCTGTTGGAAGTGG
 321 TTGCATATTTAACCTGCTGTGCAGAGCCCAGTTAATTTTTCCTTTAACTGTATTTTTAAAATTCTAATGTGAAGTCTGAT
 401 TCTCTCTTGTGGTACATTGGGGACCTCAGCTCTTAAAGGTCTCATGTTCCCAATATTTTATTTTGATTTTTTTTTTTTTT
 481 TTTTTTTTTTTTTTTTTTAGTGACTGGGTCTCACTCTGTTGCCCACACTGGAATGCAGTGGCATGATCACAGCTCTCTGC
 561 AGCCTCAATCCCCTGGGCTCAAGCAGTCCTCCCACCTCAGCCTCCTGAGTAGCTGGGACCATAGGCACATACCACCACAT
 641 CTGTCTACTTTTTGTATTTTTTGTAGAGACAGGGTTTCGCCATGTTGCCCAAGTTGGTCTTGAACTCCTGGGCTTAAGCA
 721 GTCCTGCCTCGGCTTCCCAAAATGCTAGGATTAGAGCCACCATGCCCAGCCTATTTTGATTTTTGTTTTTTTATGTTCCT
 801 TTCTAATAAATTGTAACAAATGATGTTCTCAAGTACATTTCCAGTTTCTTTTCTTTTCTTTCTTTTTTTTTTTTTTTTTT
 881 TTTTTGAGATGGAGTCTCGCTCTATCGCCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAAGCTCTACCTCCT
 961 GGGTTCACACCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCTGCCACCATGCCTGGCTAATTTTTA
1041 GTAGAGACGGGGTTTCGCAGTGTTAGCCAGGAAGGTCTCAATCTCCTGACCTCCTGATCCGCCCGCCTCGGCCTCCCAAA
1121 GTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGTTGTGCATTTCTGGTTTCTAAGAATCAAACCACTTGGCTGTTTTT
1201 AGGAGTTACTTCCCATGTTATAAAGCTGAGGAAGCTTTTTTTTTTTTTTTTTGAGACAGAGTCTCTGTCACCCAGGCTGG
1281 AGTGCAGTGGTGCAATCTCAGCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTTCTGAGTAGCTAAGATTACAGGTGT
1361 GCGCCAACACGTCTGGCTTATTTTTTTGTATTTTTAGTAGAGATGGAGTTTCACCATGTTGGTCAGGTGGGTCTCAAACT
1441 CCTGACCTCAAGTGATCCGCCCATCTCCTCCCAAAGTGCTGGATTGCAGGCATGAGCGCCTAGCCAGGAAGCTATCTTTT
1521 CTTGAGTTATGAAACTTTGCAACAGTTGTTCAAATTGGTGTTTGTCCTTCCTATAGCTTTCATATTTTCAAATTAATTCT
1601 GTATGGCTATATAATTTATGTTTTAAAAGGCAATTCTCTTGACTTTGGAAATATGGAAGTCTCTCCTTTAACCTATTCTT
1681 GTTCCCATTCCCAGTCTCATTTGAAATCATTCCTTTTATTGTTAGTGTGTGTATTTTTGTTGGTGTGCTTTTAATGCATC
1761 CAAGTATGCATCATTTTGGATAAAAAATACATCCAAATTAAGATGTTTTAACACATAGGACAAACTTGTGCACTTTTTAT
1841 GCCAAAAAAAAAAAAAATTGGGTTTTCCTTCATGGGATTTCTAGAAACACTGCCTACACTTTATGAAAACTACATAGTAT
1921 TCACCTGTGACAGGTAGAGTTTATCACTATTAATTTTATGAGGCTATTTATTACTTTCCAATGCATCCACTTAGAACAAG
2001 CTAAGAGTAAGGCTGCTAACTTTAATTCCTTGCCTGATTTTATTGTACAGTGTGCACAAGCACAATGGTATGCTTGTATA
2081 TAGAAACTAAAAATACTATGAAGTACATAAGTTCCCTATGGCTTATGGAGAGTTATTTATTAATTAACTTTATGGTAGGG
2161 CTAGTATGAATACCTTTTTAACAATTGTGTGCTATTACAACAATGAAGATTCAAATGACTCCGCTTTGAAGGATGTTTTC
2241 TCTATATGGTAAAATATATATGAAGAAGTCTTGATTACGTGAAGATCACTTGACTCAGAATACTTCAATGTATTTTGTTC
2321 ACATTACCACTAAGCATATTATCAGTAAACTATTAACTGACTGCACATTATGTAATACGTTGTACTTTTTGTTGAATTCA
2401 CCGAAGTTCTTCCATTTATATGCTATTTTTAATGGCATTCCGGCTTTAACATTCTGTGAGTCTTACAAATTTGACTCTTG
2481 AATGGCAAAATAATGTTAGTATGTAGAAGGTTAACTTTCATTTATAATATAAGTGGTGCAGGGGTTCAACATTTTAAGTA
2561 AAAATATTTTTACACACTACCTCTCTCTTTTTTTTTTTAAAGTTTTAACATCAGAACTTTTGGGGGAAAAACTACTTCAG
2641 GGCTTGACTTTTTGTACAAATTTTAACTGTAAAATACAGATTTATCTTGTACGCATTCATGGAAATGGAAATCAAAGCTG
2721 CTATTGCTTTTTATTTTAATTATCCTGTTAAGGGTATCTATCAATGGTATTTTCAAGTAGATCTCTGTTTCTTAAATTAT
2801 TGGTGAAATAATTGATTACTAGATATATTGTAAAACCAATAGATCCTGGTTATACGATAAAATATCAGCTCATTGGTAGG
2881 CTGAATCAATTATTTCAAGTGCACCTTATTAACAAAAGTATCAGTGGATCCAACATAAAATTTTATAGTACTAAATGTCA
2961 AGCCTAACTGTGAATTTTGTTCTGTATCTTAAGTAAATTTATGATAATGTTCTCGAGCTATCAACAAAATATATGTACTT
3041 TTGTGAGCTATGAATTTTCTAATTAAATTTTACATGCTATAACATGATTTTTACATGAATGATACTTTGTTTATAACTAT
3121 CAAATGTCAGTATTTTACTACAATTTTATTATAAAGTGTACATTATCACTAAATGAACTTCGATTTTAAAAATCAAATTA
3201 GCTTTAGTTGTATATTATTTTTTACAAATAAAGATAGACTTGTATAAAGGCTAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugAAAGGUC-CUAAGUAAUUGa 5'
            || :|||  |  :|||||| 
Target 5' taTTATCAGTAAACTATTAACt 3'
2337 - 2358 135.00 -8.00
2
miRNA  3' ugaaagguccUAAGUAAUUGa 5'
                    |||:|||||: 
Target 5' atggagagttATTTATTAATt 3'
2125 - 2145 123.00 -5.20
3
miRNA  3' ugAAAGGU--CC-UAA----GUAAUUGa 5'
            |||::|  || |||    | ||||| 
Target 5' taTTTTTAATGGCATTCCGGCTTTAACa 3'
2424 - 2451 123.00 -6.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30468294 5 COSMIC
COSN30486745 22 COSMIC
COSN30527144 32 COSMIC
COSN18743244 52 COSMIC
COSN30162147 91 COSMIC
COSN30699917 104 COSMIC
COSN20116550 213 COSMIC
COSN10017398 427 COSMIC
COSN18918188 456 COSMIC
COSN20116553 466 COSMIC
COSN24500477 570 COSMIC
COSN18783687 863 COSMIC
COSN26883439 1050 COSMIC
COSN24137490 1072 COSMIC
COSN1875148 1099 COSMIC
COSN18757606 1253 COSMIC
COSN32061153 1253 COSMIC
COSN24179801 1401 COSMIC
COSN31539957 1608 COSMIC
COSN31482752 1699 COSMIC
COSN26638583 1769 COSMIC
COSN25754677 1813 COSMIC
COSN22494761 1820 COSMIC
COSN31533763 1834 COSMIC
COSN20116554 1858 COSMIC
COSN27509526 1858 COSMIC
COSN31527992 1958 COSMIC
COSN20116557 2054 COSMIC
COSN21264331 2108 COSMIC
COSN9141952 2151 COSMIC
COSN31557302 2161 COSMIC
COSN31538019 2172 COSMIC
COSN31606507 2213 COSMIC
COSN31517267 2218 COSMIC
COSN31531672 2224 COSMIC
COSN30167004 2241 COSMIC
COSN8000506 2280 COSMIC
COSN19658417 2379 COSMIC
COSN8611096 2530 COSMIC
COSN30159424 2540 COSMIC
COSN20116560 2589 COSMIC
COSN29479727 2589 COSMIC
COSN29520115 2589 COSMIC
COSN31594824 2589 COSMIC
COSN2378187 2590 COSMIC
COSN20093783 2600 COSMIC
COSN26586212 2655 COSMIC
COSN31527587 2660 COSMIC
COSN26566540 2690 COSMIC
COSN31547377 3000 COSMIC
COSN27334889 3051 COSMIC
COSN22492266 3084 COSMIC
COSN1875150 3161 COSMIC
COSN31517550 3182 COSMIC
COSN5865623 3207 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs754313679 5 dbSNP
rs757732660 6 dbSNP
rs778888284 14 dbSNP
rs55948332 15 dbSNP
rs1170150136 22 dbSNP
rs570513096 26 dbSNP
rs535715022 30 dbSNP
rs1046591778 31 dbSNP
rs1463708439 32 dbSNP
rs201932178 34 dbSNP
rs1405354298 38 dbSNP
rs969799775 39 dbSNP
rs1450392017 40 dbSNP
rs780241995 41 dbSNP
rs1379782896 42 dbSNP
rs1381484045 45 dbSNP
rs781224904 48 dbSNP
rs188527390 49 dbSNP
rs769585502 50 dbSNP
rs6020721 52 dbSNP
rs749209201 53 dbSNP
rs962309741 54 dbSNP
rs1159930260 67 dbSNP
rs1420898362 70 dbSNP
rs1469627445 71 dbSNP
rs888427498 72 dbSNP
rs149899269 73 dbSNP
rs557478129 76 dbSNP
rs964085781 78 dbSNP
rs976590245 85 dbSNP
rs1484733184 86 dbSNP
rs1411711804 91 dbSNP
rs1029496289 92 dbSNP
rs1354383092 99 dbSNP
rs967702361 108 dbSNP
rs144921171 109 dbSNP
rs1341982976 110 dbSNP
rs796621690 116 dbSNP
rs761528619 117 dbSNP
rs1353167431 121 dbSNP
rs1299556739 128 dbSNP
rs1328620421 130 dbSNP
rs1400051048 130 dbSNP
rs370336354 132 dbSNP
rs765011227 133 dbSNP
rs538058226 134 dbSNP
rs1459778272 140 dbSNP
rs1369342139 147 dbSNP
rs1442481844 148 dbSNP
rs1280991215 173 dbSNP
rs944364644 178 dbSNP
rs1376320899 181 dbSNP
rs777891584 185 dbSNP
rs1040056630 196 dbSNP
rs1259407454 197 dbSNP
rs1194524838 199 dbSNP
rs924514128 203 dbSNP
rs1260983322 204 dbSNP
rs1203242272 208 dbSNP
rs143588050 211 dbSNP
rs556688996 211 dbSNP
rs79199393 212 dbSNP
rs201394798 213 dbSNP
rs915696401 229 dbSNP
rs1054190635 230 dbSNP
rs149031514 231 dbSNP
rs1325297588 237 dbSNP
rs759723891 242 dbSNP
rs1196460991 243 dbSNP
rs906666406 244 dbSNP
rs376192736 247 dbSNP
rs1460171074 252 dbSNP
rs192900373 258 dbSNP
rs888680511 260 dbSNP
rs1003525649 262 dbSNP
rs1438249356 279 dbSNP
rs1206873421 280 dbSNP
rs1035045288 287 dbSNP
rs1235993743 288 dbSNP
rs1267937835 292 dbSNP
rs1212874157 298 dbSNP
rs962258783 298 dbSNP
rs993767544 314 dbSNP
rs144895071 318 dbSNP
rs1267955920 325 dbSNP
rs1234752122 328 dbSNP
rs952321016 335 dbSNP
rs1018224627 338 dbSNP
rs752673193 339 dbSNP
rs1420580471 340 dbSNP
rs756660274 352 dbSNP
rs1402833622 356 dbSNP
rs1029917445 370 dbSNP
rs967208997 378 dbSNP
rs1420658470 384 dbSNP
rs6091206 385 dbSNP
rs546208886 386 dbSNP
rs1032957532 388 dbSNP
rs778078638 399 dbSNP
rs1192871023 402 dbSNP
rs1452349625 407 dbSNP
rs1239846795 409 dbSNP
rs957266089 410 dbSNP
rs80287642 411 dbSNP
rs1345048016 413 dbSNP
rs867054268 415 dbSNP
rs146742474 416 dbSNP
rs1232827863 418 dbSNP
rs934558054 419 dbSNP
rs990477786 422 dbSNP
rs1441896977 426 dbSNP
rs1357212876 430 dbSNP
rs6091207 433 dbSNP
rs1216713675 436 dbSNP
rs914527234 438 dbSNP
rs6091208 442 dbSNP
rs1374860377 445 dbSNP
rs549731858 446 dbSNP
rs368499557 450 dbSNP
rs1432844461 453 dbSNP
rs1339802576 454 dbSNP
rs1177607709 456 dbSNP
rs1216148955 459 dbSNP
rs1189120737 461 dbSNP
rs1276717103 461 dbSNP
rs13042106 462 dbSNP
rs561886968 466 dbSNP
rs1159680960 467 dbSNP
rs1164767946 467 dbSNP
rs1185203622 467 dbSNP
rs1215623835 467 dbSNP
rs1234254009 467 dbSNP
rs1243216434 467 dbSNP
rs1256330565 467 dbSNP
rs1286182780 467 dbSNP
rs1292537570 467 dbSNP
rs1297772996 467 dbSNP
rs1311188425 467 dbSNP
rs1348917423 467 dbSNP
rs1355040140 467 dbSNP
rs1362409613 467 dbSNP
rs1399908708 467 dbSNP
rs1401885757 467 dbSNP
rs1405436492 467 dbSNP
rs1445774586 467 dbSNP
rs1449121458 467 dbSNP
rs1475359624 467 dbSNP
rs529065443 467 dbSNP
rs565068464 467 dbSNP
rs570743847 467 dbSNP
rs747693162 467 dbSNP
rs760557420 467 dbSNP
rs779056660 467 dbSNP
rs1347447193 478 dbSNP
rs1211606130 479 dbSNP
rs867658926 480 dbSNP
rs866426045 481 dbSNP
rs1334488236 484 dbSNP
rs1259698922 486 dbSNP
rs1291622323 486 dbSNP
rs1341146087 488 dbSNP
rs1487382935 490 dbSNP
rs1193080140 491 dbSNP
rs1243243528 493 dbSNP
rs1289379301 493 dbSNP
rs1430014756 495 dbSNP
rs1343341529 496 dbSNP
rs1325326832 498 dbSNP
rs1416748044 499 dbSNP
rs971142242 499 dbSNP
rs1446569385 500 dbSNP
rs76966666 501 dbSNP
rs1171209598 503 dbSNP
rs1392812816 504 dbSNP
rs1433715838 505 dbSNP
rs1185421793 506 dbSNP
rs1173947713 508 dbSNP
rs1376728954 509 dbSNP
rs1380077365 510 dbSNP
rs547317939 514 dbSNP
rs981183306 517 dbSNP
rs928143959 519 dbSNP
rs1044259004 525 dbSNP
rs1200685633 528 dbSNP
rs930185990 529 dbSNP
rs1432569305 535 dbSNP
rs1047664083 541 dbSNP
rs1295007718 542 dbSNP
rs201112385 544 dbSNP
rs905260565 545 dbSNP
rs1276495298 551 dbSNP
rs565637020 552 dbSNP
rs1441385868 555 dbSNP
rs1393374945 573 dbSNP
rs539088628 579 dbSNP
rs1323644590 581 dbSNP
rs1466918036 583 dbSNP
rs138005847 584 dbSNP
rs1169179148 586 dbSNP
rs1056454121 590 dbSNP
rs897831258 595 dbSNP
rs1194743572 597 dbSNP
rs1454109538 599 dbSNP
rs1251595063 601 dbSNP
rs1180885086 603 dbSNP
rs1481105379 607 dbSNP
rs1250932854 608 dbSNP
rs376404812 616 dbSNP
rs1235283261 623 dbSNP
rs1202553628 629 dbSNP
rs1313967674 632 dbSNP
rs569432280 636 dbSNP
rs993715568 637 dbSNP
rs1301047878 657 dbSNP
rs1028314420 671 dbSNP
rs1373642482 672 dbSNP
rs1297195731 679 dbSNP
rs537112908 680 dbSNP
rs1173710508 683 dbSNP
rs1039682886 684 dbSNP
rs899810660 687 dbSNP
rs998238328 692 dbSNP
rs1285520333 693 dbSNP
rs6096079 696 dbSNP
rs903252909 711 dbSNP
rs575005213 712 dbSNP
rs1031261178 722 dbSNP
rs535667607 729 dbSNP
rs989869894 731 dbSNP
rs1278046419 732 dbSNP
rs1455019221 737 dbSNP
rs914453026 739 dbSNP
rs998732498 739 dbSNP
rs772257139 741 dbSNP
rs1389387107 746 dbSNP
rs1033256288 747 dbSNP
rs957274538 751 dbSNP
rs1012804639 757 dbSNP
rs948692232 762 dbSNP
rs1413585875 765 dbSNP
rs1157505397 768 dbSNP
rs1022647838 775 dbSNP
rs1160912810 779 dbSNP
rs971025809 780 dbSNP
rs1363649561 786 dbSNP
rs1157354000 792 dbSNP
rs113583294 793 dbSNP
rs34538740 793 dbSNP
rs1484706050 794 dbSNP
rs1255340022 796 dbSNP
rs1206757456 811 dbSNP
rs928469887 813 dbSNP
rs184537114 821 dbSNP
rs150428245 835 dbSNP
rs1323874152 845 dbSNP
rs1336534949 845 dbSNP
rs1293475928 846 dbSNP
rs1232164121 850 dbSNP
rs1319709427 850 dbSNP
rs1383325213 854 dbSNP
rs1369949090 857 dbSNP
rs1056569319 859 dbSNP
rs1384839860 859 dbSNP
rs201491403 859 dbSNP
rs1441423406 860 dbSNP
rs1305853985 862 dbSNP
rs11467364 863 dbSNP
rs1164415325 863 dbSNP
rs1193979115 863 dbSNP
rs1212755405 863 dbSNP
rs1227474918 863 dbSNP
rs1260919255 863 dbSNP
rs1271476052 863 dbSNP
rs1273428525 863 dbSNP
rs1294002024 863 dbSNP
rs1326385443 863 dbSNP
rs1332198407 863 dbSNP
rs1425958525 863 dbSNP
rs144055406 863 dbSNP
rs1443588738 863 dbSNP
rs565736663 863 dbSNP
rs761505160 863 dbSNP
rs770602840 863 dbSNP
rs772794532 863 dbSNP
rs869246068 863 dbSNP
rs1395593358 864 dbSNP
rs1334228060 866 dbSNP
rs1325649039 867 dbSNP
rs1398882442 868 dbSNP
rs1238343241 869 dbSNP
rs1461502995 870 dbSNP
rs1280210916 871 dbSNP
rs1353011671 883 dbSNP
rs1455527567 884 dbSNP
rs1212349045 885 dbSNP
rs1273163113 886 dbSNP
rs1466886883 886 dbSNP
rs1274621045 887 dbSNP
rs1469163572 888 dbSNP
rs1215975102 890 dbSNP
rs1338113745 891 dbSNP
rs1250135961 899 dbSNP
rs189370998 900 dbSNP
rs1303195229 903 dbSNP
rs182257849 905 dbSNP
rs1180730145 907 dbSNP
rs1409456331 915 dbSNP
rs564446791 922 dbSNP
rs866838733 929 dbSNP
rs576476319 930 dbSNP
rs543932994 931 dbSNP
rs576215792 932 dbSNP
rs1476888408 935 dbSNP
rs1234273194 937 dbSNP
rs187247389 943 dbSNP
rs1247880291 947 dbSNP
rs897946912 949 dbSNP
rs1393688466 951 dbSNP
rs1461728748 953 dbSNP
rs1280196006 955 dbSNP
rs529135400 956 dbSNP
rs547181861 957 dbSNP
rs931275984 960 dbSNP
rs1353203519 963 dbSNP
rs1327688399 965 dbSNP
rs1280499040 971 dbSNP
rs1441825645 972 dbSNP
rs1334180103 983 dbSNP
rs559224428 992 dbSNP
rs1391032389 994 dbSNP
rs1376011332 995 dbSNP
rs7273801 999 dbSNP
rs1412554191 1008 dbSNP
rs888014960 1010 dbSNP
rs1231574164 1013 dbSNP
rs550975876 1014 dbSNP
rs1007824794 1015 dbSNP
rs1235460586 1016 dbSNP
rs981498429 1025 dbSNP
rs532456683 1027 dbSNP
rs6013008 1028 dbSNP
rs1449220964 1029 dbSNP
rs1285450210 1042 dbSNP
rs1223542669 1049 dbSNP
rs1031378895 1050 dbSNP
rs1295294255 1053 dbSNP
rs955810662 1057 dbSNP
rs370377076 1058 dbSNP
rs1194854219 1060 dbSNP
rs990208270 1061 dbSNP
rs1318773987 1066 dbSNP
rs1399858134 1074 dbSNP
rs1386027405 1075 dbSNP
rs530403322 1078 dbSNP
rs970355320 1082 dbSNP
rs1416598941 1084 dbSNP
rs983011900 1089 dbSNP
rs937455683 1090 dbSNP
rs910014591 1094 dbSNP
rs202064492 1095 dbSNP
rs1439006282 1101 dbSNP
rs374753508 1102 dbSNP
rs921283170 1104 dbSNP
rs8126455 1105 dbSNP
rs1051527808 1106 dbSNP
rs189017935 1108 dbSNP
rs959852062 1110 dbSNP
rs999304436 1111 dbSNP
rs1298928348 1114 dbSNP
rs972601259 1122 dbSNP
rs764693463 1125 dbSNP
rs929437680 1129 dbSNP
rs892944303 1133 dbSNP
rs1049504654 1137 dbSNP
rs909234919 1138 dbSNP
rs1012855080 1139 dbSNP
rs1420860172 1143 dbSNP
rs1022914286 1147 dbSNP
rs1398945997 1148 dbSNP
rs75343091 1149 dbSNP
rs1002578242 1150 dbSNP
rs1026399682 1151 dbSNP
rs950499746 1159 dbSNP
rs902139717 1163 dbSNP
rs375977861 1167 dbSNP
rs1356253502 1170 dbSNP
rs1273633233 1178 dbSNP
rs1017071268 1180 dbSNP
rs1339948082 1182 dbSNP
rs1305403319 1183 dbSNP
rs1294119822 1199 dbSNP
rs962827858 1201 dbSNP
rs1369815134 1203 dbSNP
rs975538435 1204 dbSNP
rs1291367800 1208 dbSNP
rs921551251 1216 dbSNP
rs867836938 1221 dbSNP
rs934232641 1226 dbSNP
rs986820638 1228 dbSNP
rs7260805 1229 dbSNP
rs934773735 1231 dbSNP
rs1208021280 1234 dbSNP
rs1282316301 1236 dbSNP
rs1340009659 1236 dbSNP
rs569339357 1236 dbSNP
rs879217590 1236 dbSNP
rs1256185173 1237 dbSNP
rs1485744679 1244 dbSNP
rs1311321896 1249 dbSNP
rs1001642921 1253 dbSNP
rs1225177518 1253 dbSNP
rs866075035 1254 dbSNP
rs1197848156 1255 dbSNP
rs1276683715 1256 dbSNP
rs1407414950 1257 dbSNP
rs540104018 1260 dbSNP
rs1313962097 1264 dbSNP
rs1434493491 1266 dbSNP
rs1170905486 1270 dbSNP
rs1376353727 1271 dbSNP
rs1161704347 1272 dbSNP
rs1419940524 1278 dbSNP
rs1407475800 1280 dbSNP
rs1035603736 1286 dbSNP
rs140988923 1287 dbSNP
rs1259529894 1289 dbSNP
rs1433097795 1290 dbSNP
rs1211589271 1300 dbSNP
rs369591808 1307 dbSNP
rs893205959 1308 dbSNP
rs1317180019 1310 dbSNP
rs1287269223 1314 dbSNP
rs181369950 1319 dbSNP
rs779635004 1322 dbSNP
rs1293369045 1326 dbSNP
rs918437692 1328 dbSNP
rs950839313 1334 dbSNP
rs1400649977 1335 dbSNP
rs555872392 1336 dbSNP
rs1291030727 1346 dbSNP
rs984898070 1354 dbSNP
rs1361899974 1362 dbSNP
rs907158123 1363 dbSNP
rs868074329 1364 dbSNP
rs1383074654 1365 dbSNP
rs1298196747 1369 dbSNP
rs746444041 1371 dbSNP
rs768642474 1372 dbSNP
rs1206699375 1377 dbSNP
rs1486039405 1380 dbSNP
rs1039032459 1381 dbSNP
rs574011045 1382 dbSNP
rs1336478175 1397 dbSNP
rs1279220272 1399 dbSNP
rs933586534 1405 dbSNP
rs1243378988 1413 dbSNP
rs1015991324 1416 dbSNP
rs1211656280 1417 dbSNP
rs540846648 1423 dbSNP
rs1485510864 1424 dbSNP
rs1011706961 1426 dbSNP
rs1042805083 1432 dbSNP
rs975592178 1434 dbSNP
rs1318938464 1442 dbSNP
rs1028406990 1445 dbSNP
rs1249649540 1446 dbSNP
rs559084750 1450 dbSNP
rs1452397378 1453 dbSNP
rs1193209245 1457 dbSNP
rs185504621 1459 dbSNP
rs1195158564 1460 dbSNP
rs544926989 1460 dbSNP
rs1429047374 1463 dbSNP
rs1247251328 1469 dbSNP
rs924651013 1471 dbSNP
rs934679501 1483 dbSNP
rs1469559851 1488 dbSNP
rs1345050969 1493 dbSNP
rs1208738571 1497 dbSNP
rs868393968 1498 dbSNP
rs990139079 1499 dbSNP
rs7268617 1502 dbSNP
rs1342041039 1504 dbSNP
rs143302333 1507 dbSNP
rs952585298 1512 dbSNP
rs984396838 1515 dbSNP
rs1323080231 1519 dbSNP
rs59057701 1522 dbSNP
rs373025799 1525 dbSNP
rs965184248 1530 dbSNP
rs148559733 1531 dbSNP
rs938626443 1539 dbSNP
rs1166504894 1540 dbSNP
rs1267911811 1541 dbSNP
rs1455374786 1574 dbSNP
rs1246930036 1575 dbSNP
rs7268691 1586 dbSNP
rs377231688 1591 dbSNP
rs1315881268 1598 dbSNP
rs1210852070 1601 dbSNP
rs142586330 1602 dbSNP
rs913507712 1611 dbSNP
rs566311579 1613 dbSNP
rs1269984416 1634 dbSNP
rs1273053336 1636 dbSNP
rs1236979488 1640 dbSNP
rs1348967616 1641 dbSNP
rs1274626393 1654 dbSNP
rs35346940 1655 dbSNP
rs1466941141 1659 dbSNP
rs1005875909 1660 dbSNP
rs947576524 1664 dbSNP
rs539442197 1665 dbSNP
rs1306035907 1666 dbSNP
rs1436495914 1666 dbSNP
rs1253804582 1667 dbSNP
rs905600409 1669 dbSNP
rs1037326974 1677 dbSNP
rs937088394 1682 dbSNP
rs1476858282 1686 dbSNP
rs76228262 1687 dbSNP
rs995848231 1688 dbSNP
rs895488593 1690 dbSNP
rs994053296 1697 dbSNP
rs1213728370 1701 dbSNP
rs1025555097 1707 dbSNP
rs1028459231 1709 dbSNP
rs6091209 1714 dbSNP
rs1417242301 1723 dbSNP
rs955702896 1749 dbSNP
rs769617961 1755 dbSNP
rs150947689 1764 dbSNP
rs1227865858 1773 dbSNP
rs1327008625 1778 dbSNP
rs1005368813 1797 dbSNP
rs1359637698 1798 dbSNP
rs1333300704 1817 dbSNP
rs1386705873 1826 dbSNP
rs1412497023 1826 dbSNP
rs1159363904 1829 dbSNP
rs1472057921 1830 dbSNP
rs1394680309 1831 dbSNP
rs537463832 1832 dbSNP
rs1193552131 1834 dbSNP
rs1473436574 1837 dbSNP
rs45624032 1838 dbSNP
rs1185885075 1839 dbSNP
rs1296143089 1842 dbSNP
rs1449034043 1842 dbSNP
rs1371944151 1843 dbSNP
rs1208404847 1844 dbSNP
rs1269157928 1844 dbSNP
rs1275166387 1844 dbSNP
rs35818153 1844 dbSNP
rs5841810 1844 dbSNP
rs869028690 1844 dbSNP
rs869105379 1844 dbSNP
rs200256456 1845 dbSNP
rs62202831 1858 dbSNP
rs1233929220 1860 dbSNP
rs956309733 1864 dbSNP
rs1283470346 1868 dbSNP
rs6096080 1869 dbSNP
rs964800035 1871 dbSNP
rs1328056229 1872 dbSNP
rs990189556 1885 dbSNP
rs974799946 1890 dbSNP
rs6096081 1895 dbSNP
rs1385953253 1901 dbSNP
rs767579672 1903 dbSNP
rs766153282 1904 dbSNP
rs947655653 1906 dbSNP
rs574093095 1910 dbSNP
rs1188288230 1917 dbSNP
rs6091210 1926 dbSNP
rs1255070743 1927 dbSNP
rs1222423322 1940 dbSNP
rs937036207 1945 dbSNP
rs1056911266 1946 dbSNP
rs1341361346 1948 dbSNP
rs537259506 1948 dbSNP
rs1298116533 1958 dbSNP
rs1434039467 1967 dbSNP
rs1453174119 1970 dbSNP
rs1362596707 1971 dbSNP
rs980154844 1978 dbSNP
rs541159192 1979 dbSNP
rs1054185 1982 dbSNP
rs1320985035 1987 dbSNP
rs760736187 1988 dbSNP
rs1047195321 1998 dbSNP
rs139465911 2008 dbSNP
rs544794289 2010 dbSNP
rs1447985306 2017 dbSNP
rs1005897997 2028 dbSNP
rs1443605265 2030 dbSNP
rs563608263 2039 dbSNP
rs11469337 2050 dbSNP
rs11469424 2050 dbSNP
rs1488273830 2050 dbSNP
rs1416394220 2051 dbSNP
rs907822123 2054 dbSNP
rs941911610 2055 dbSNP
rs998006822 2062 dbSNP
rs1275209910 2064 dbSNP
rs1167831732 2065 dbSNP
rs1353585771 2074 dbSNP
rs1409843299 2086 dbSNP
rs1037336937 2092 dbSNP
rs1309325011 2097 dbSNP
rs1353098445 2098 dbSNP
rs1366426233 2100 dbSNP
rs1414084171 2101 dbSNP
rs900147450 2107 dbSNP
rs1371726652 2108 dbSNP
rs995898949 2115 dbSNP
rs530669203 2116 dbSNP
rs1358159206 2117 dbSNP
rs542630079 2129 dbSNP
rs1177214870 2139 dbSNP
rs1377713629 2139 dbSNP
rs1432861887 2143 dbSNP
rs534377644 2145 dbSNP
rs1179051530 2148 dbSNP
rs1010225370 2164 dbSNP
rs754441075 2166 dbSNP
rs757803580 2167 dbSNP
rs1204418728 2168 dbSNP
rs373191418 2175 dbSNP
rs1257578870 2177 dbSNP
rs528078397 2188 dbSNP
rs1031838361 2195 dbSNP
rs956281548 2198 dbSNP
rs1298662151 2199 dbSNP
rs1189231763 2204 dbSNP
rs1350650690 2213 dbSNP
rs1239755233 2215 dbSNP
rs1408595003 2216 dbSNP
rs1474604345 2219 dbSNP
rs546746042 2222 dbSNP
rs190264843 2223 dbSNP
rs112854632 2224 dbSNP
rs6096082 2232 dbSNP
rs1411389453 2238 dbSNP
rs372831252 2238 dbSNP
rs551644052 2244 dbSNP
rs1429999195 2245 dbSNP
rs970022998 2247 dbSNP
rs916987315 2248 dbSNP
rs1182245677 2250 dbSNP
rs980081609 2257 dbSNP
rs928741061 2259 dbSNP
rs570333273 2261 dbSNP
rs73276585 2271 dbSNP
rs1046701876 2279 dbSNP
rs1329395946 2284 dbSNP
rs1266990498 2288 dbSNP
rs909540248 2291 dbSNP
rs1342216834 2295 dbSNP
rs777022929 2296 dbSNP
rs1040017299 2300 dbSNP
rs1377508443 2301 dbSNP
rs1428309675 2304 dbSNP
rs183253488 2305 dbSNP
rs186056261 2309 dbSNP
rs117000341 2311 dbSNP
rs1278519417 2330 dbSNP
rs1050913706 2332 dbSNP
rs1463025520 2335 dbSNP
rs371683106 2337 dbSNP
rs190963477 2343 dbSNP
rs111984714 2351 dbSNP
rs1253877920 2379 dbSNP
rs746669466 2383 dbSNP
rs969131862 2386 dbSNP
rs1246980946 2401 dbSNP
rs1193180564 2403 dbSNP
rs1000236645 2404 dbSNP
rs1034599673 2418 dbSNP
rs1244757181 2420 dbSNP
rs958969266 2421 dbSNP
rs6096083 2423 dbSNP
rs1190080052 2424 dbSNP
rs1392907574 2433 dbSNP
rs1051428599 2435 dbSNP
rs556849333 2436 dbSNP
rs544001189 2437 dbSNP
rs376436316 2442 dbSNP
rs1053706994 2443 dbSNP
rs1292994488 2444 dbSNP
rs982945582 2451 dbSNP
rs6126089 2467 dbSNP
rs1317624913 2470 dbSNP
rs183937302 2497 dbSNP
rs941020659 2503 dbSNP
rs561214926 2504 dbSNP
rs572925354 2511 dbSNP
rs1267484745 2514 dbSNP
rs1370551382 2520 dbSNP
rs921166997 2521 dbSNP
rs1233977880 2525 dbSNP
rs1229603768 2527 dbSNP
rs540226281 2528 dbSNP
rs933922245 2529 dbSNP
rs1050861474 2530 dbSNP
rs1021908651 2531 dbSNP
rs564984042 2543 dbSNP
rs1235761200 2545 dbSNP
rs1331867998 2548 dbSNP
rs769671311 2550 dbSNP
rs1300716277 2560 dbSNP
rs892304120 2565 dbSNP
rs1363657210 2571 dbSNP
rs1309705707 2576 dbSNP
rs1348709182 2578 dbSNP
rs1001976678 2579 dbSNP
rs11469346 2581 dbSNP
rs143762554 2581 dbSNP
rs1478822189 2581 dbSNP
rs1491529381 2581 dbSNP
rs779196608 2581 dbSNP
rs1491402270 2582 dbSNP
rs1010287860 2584 dbSNP
rs1042187965 2586 dbSNP
rs904646774 2586 dbSNP
rs201988460 2587 dbSNP
rs1000588678 2588 dbSNP
rs1289039946 2588 dbSNP
rs1361240632 2588 dbSNP
rs1491163164 2588 dbSNP
rs1491541412 2588 dbSNP
rs201229227 2588 dbSNP
rs781547758 2588 dbSNP
rs34049117 2589 dbSNP
rs6096084 2590 dbSNP
rs983527106 2591 dbSNP
rs1014727970 2592 dbSNP
rs1171701765 2598 dbSNP
rs532198533 2599 dbSNP
rs187709109 2600 dbSNP
rs200895732 2601 dbSNP
rs1182232327 2603 dbSNP
rs921885320 2604 dbSNP
rs1472569549 2609 dbSNP
rs1199208741 2613 dbSNP
rs1231622304 2614 dbSNP
rs1190069963 2622 dbSNP
rs1443291055 2623 dbSNP
rs1278360254 2626 dbSNP
rs1378846454 2628 dbSNP
rs374046264 2637 dbSNP
rs987546639 2641 dbSNP
rs1331445208 2643 dbSNP
rs1268880668 2644 dbSNP
rs911530468 2645 dbSNP
rs1468198595 2650 dbSNP
rs1277630568 2653 dbSNP
rs894704316 2655 dbSNP
rs1157897526 2660 dbSNP
rs935091235 2661 dbSNP
rs1333234984 2666 dbSNP
rs1014515760 2668 dbSNP
rs1450063316 2668 dbSNP
rs563761774 2677 dbSNP
rs1458566355 2682 dbSNP
rs773006510 2683 dbSNP
rs1456195679 2686 dbSNP
rs1406436156 2690 dbSNP
rs1323653887 2693 dbSNP
rs192202037 2694 dbSNP
rs1387555602 2704 dbSNP
rs1466436840 2709 dbSNP
rs746018498 2712 dbSNP
rs1334029457 2724 dbSNP
rs1238465564 2737 dbSNP
rs1445418135 2745 dbSNP
rs1292095094 2748 dbSNP
rs80162740 2757 dbSNP
rs770759181 2761 dbSNP
rs1354180079 2763 dbSNP
rs115752561 2765 dbSNP
rs1231769051 2782 dbSNP
rs1243436508 2783 dbSNP
rs78735395 2784 dbSNP
rs1320735064 2794 dbSNP
rs78174724 2800 dbSNP
rs571428756 2808 dbSNP
rs183186349 2813 dbSNP
rs1324932270 2816 dbSNP
rs371080969 2817 dbSNP
rs1269071845 2818 dbSNP
rs1406488407 2827 dbSNP
rs1413641639 2829 dbSNP
rs933886094 2833 dbSNP
rs764305427 2840 dbSNP
rs1028745648 2841 dbSNP
rs1188230954 2845 dbSNP
rs953428006 2846 dbSNP
rs945184195 2856 dbSNP
rs1248568441 2862 dbSNP
rs1043603761 2863 dbSNP
rs1222348499 2863 dbSNP
rs1290873593 2864 dbSNP
rs987379680 2866 dbSNP
rs1344138522 2870 dbSNP
rs146760168 2871 dbSNP
rs762429493 2882 dbSNP
rs1359376660 2886 dbSNP
rs575376907 2890 dbSNP
rs187516081 2897 dbSNP
rs1349810832 2899 dbSNP
rs1416872542 2903 dbSNP
rs1301907858 2905 dbSNP
rs554946775 2907 dbSNP
rs915028862 2908 dbSNP
rs1014295137 2909 dbSNP
rs1371610240 2914 dbSNP
rs1168318228 2915 dbSNP
rs1024546136 2916 dbSNP
rs1458260411 2919 dbSNP
rs1191860171 2920 dbSNP
rs1165183803 2921 dbSNP
rs1477701786 2936 dbSNP
rs747347729 2947 dbSNP
rs769336512 2954 dbSNP
rs1197265384 2958 dbSNP
rs1483984141 2964 dbSNP
rs1004781474 2969 dbSNP
rs1275140070 2969 dbSNP
rs1017111015 2980 dbSNP
rs1043254062 2984 dbSNP
rs927415466 2987 dbSNP
rs573136719 2992 dbSNP
rs937608028 2998 dbSNP
rs1280215181 3000 dbSNP
rs962737579 3001 dbSNP
rs975150206 3007 dbSNP
rs1027916135 3013 dbSNP
rs1057395261 3015 dbSNP
rs1352476068 3020 dbSNP
rs1412267508 3020 dbSNP
rs1351597443 3021 dbSNP
rs1413457668 3022 dbSNP
rs1307834416 3024 dbSNP
rs1460736561 3030 dbSNP
rs955028064 3032 dbSNP
rs1414112649 3033 dbSNP
rs896041047 3038 dbSNP
rs1161426533 3039 dbSNP
rs1473543012 3039 dbSNP
rs1247484904 3043 dbSNP
rs1266786268 3044 dbSNP
rs375583186 3048 dbSNP
rs1479572085 3051 dbSNP
rs1238973161 3061 dbSNP
rs1337047863 3064 dbSNP
rs1322360560 3066 dbSNP
rs1204087211 3071 dbSNP
rs540237901 3072 dbSNP
rs1004916738 3077 dbSNP
rs1036316137 3081 dbSNP
rs1229648846 3084 dbSNP
rs1330443887 3092 dbSNP
rs1306831753 3095 dbSNP
rs781127420 3100 dbSNP
rs945345443 3106 dbSNP
rs994849156 3110 dbSNP
rs1303773340 3116 dbSNP
rs1185676460 3118 dbSNP
rs192761698 3122 dbSNP
rs1404136175 3123 dbSNP
rs1161476036 3129 dbSNP
rs953217171 3135 dbSNP
rs1424130902 3136 dbSNP
rs1189374439 3144 dbSNP
rs1417212552 3149 dbSNP
rs925161409 3156 dbSNP
rs576889547 3157 dbSNP
rs936057205 3170 dbSNP
rs1009129265 3182 dbSNP
rs1018892608 3183 dbSNP
rs1461664594 3184 dbSNP
rs894588349 3188 dbSNP
rs555381722 3191 dbSNP
rs1372459365 3202 dbSNP
rs956827118 3208 dbSNP
rs1237592428 3215 dbSNP
rs544001803 3216 dbSNP
rs1323999775 3217 dbSNP
rs1312761773 3218 dbSNP
rs987846138 3220 dbSNP
rs548248035 3222 dbSNP
rs74274301 3226 dbSNP
rs1398085091 3228 dbSNP
rs1380856023 3231 dbSNP
rs1293877569 3237 dbSNP
rs1436066041 3241 dbSNP
rs1326272610 3243 dbSNP
rs914875161 3248 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 84612.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760632. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_C ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_032521 | 3UTR | UAUUGGUGAAAUAAUUGAUUACUAGAUAUAUUGUAAAACCAAUAGAUCCUGGUUAUACGAUAAAAUAUCAGCUCAUUGGUAGGCUGAAUCAAUUAUUUCAAGUGCACCUUAUUAACAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_032521 | 3UTR | UUGGUGAAAUAAUUGAUUACUAGAUAUAUUGUAAAACCAAUAGAUCCUGGUUAUACGAUAAAAUAUCAGCUCAUUGGUAGGCUGAAUCAAUUAUUUCAAGUGCACCUUAUUAACAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_032521 | 3UTR | AUAAUUGAUUACUAGAUAUAUUGUAAAACCAAUAGAUCCUGGUUAUACGAUAAAAUAUCAGCUCAUUGGUAGGCUGAAUCAAUUAUUUCAAGUGCACCUUAUUAACAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_032521 | 3UTR | UAGAUAUAUUGUAAAACCAAUAGAUCCUGGUUAUACGAUAAAAUAUCAGCUCAUUGGUAGGCUGAAUCAAUUAUUUCAAGUGCACCUUAUUAACAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_032521 | 3UTR | UUAUACGAUAAAAUAUCAGCUCAUUGGUAGGCUGAAUCAAUUAUUUCAAGUGCACCUUAUUAACAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_032521 | 3UTR | AUAUUGUAAAACCAAUAGAUCCUGGUUAUACGAUAAAAUAUCAGCUCAUUGGUAGGCUGAAUCAAUUAUUUCAAGUGCACCUUAUUAACAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000371610.2 | 3UTR | AAUCAAUUAUUUCAAGUGCACCUUAUUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000371610.2 | 3UTR | AAUCAAUUAUUUCAAGUGCACCUUAUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000371610.2 | 3UTR | AAUCAAUUAUUUCAAGUGCACCUUAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000371610.2 | 3UTR | AAUCAAUUAUUUCAAGUGCACCUUAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000371610.2 | 3UTR | AAUCAAUUAUUUCAAGUGCACCUUAUUAACAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000371610.2 | 3UTR | AAUCAAUUAUUUCAAGUGCACCUUAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE14794 Lymphoblastoid cells 0.152 7.6e-2 0.167 5.8e-2 90 Click to see details
GSE17498 Multiple myeloma 0.189 1.2e-1 0.117 2.4e-1 40 Click to see details
GSE28544 Breast cancer -0.2 1.7e-1 -0.251 1.2e-1 24 Click to see details
GSE27834 Pluripotent stem cells -0.179 2.5e-1 -0.179 2.5e-1 16 Click to see details
GSE28260 Renal cortex and medulla 0.168 2.9e-1 0.258 2.0e-1 13 Click to see details
GSE38226 Liver fibrosis 0.09 3.5e-1 0.104 3.3e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.067 3.8e-1 0.131 2.7e-1 25 Click to see details
GSE26953 Aortic valvular endothelial cells -0.064 3.8e-1 -0.148 2.5e-1 24 Click to see details
GSE32688 Pancreatic cancer 0.043 4.1e-1 -0.154 2.0e-1 32 Click to see details
GSE21687 Ependynoma primary tumors -0.022 4.3e-1 0.042 3.7e-1 64 Click to see details
GSE17306 Multiple myeloma -0.021 4.4e-1 0.455 5.1e-4 49 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.023 4.6e-1 -0.239 1.6e-1 20 Click to see details
GSE42095 Differentiated embryonic stem cells 0.004 4.9e-1 0.271 1.1e-1 23 Click to see details
GSE42095 Differentiated embryonic stem cells 0.004 4.9e-1 0.271 1.1e-1 23 Click to see details
GSE42095 Differentiated embryonic stem cells 0.004 4.9e-1 0.271 1.1e-1 23 Click to see details
GSE42095 Differentiated embryonic stem cells 0.004 4.9e-1 0.271 1.1e-1 23 Click to see details
GSE42095 Differentiated embryonic stem cells 0.004 4.9e-1 0.271 1.1e-1 23 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
58 hsa-miR-569 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004827 SPI1 Spi-1 proto-oncogene 2 1
MIRT086537 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT086545 MOB4 MOB family member 4, phocein 2 2
MIRT154349 PARD6B par-6 family cell polarity regulator beta 2 4
MIRT182174 POU2F1 POU class 2 homeobox 1 2 2
MIRT190452 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT191410 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT199846 CSNK1G2 casein kinase 1 gamma 2 2 2
MIRT208376 SLC25A36 solute carrier family 25 member 36 2 2
MIRT275677 CARKD NAD(P)HX dehydratase 2 2
MIRT275764 TFDP1 transcription factor Dp-1 2 2
MIRT280470 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2 2
MIRT296592 FAM217B family with sequence similarity 217 member B 2 4
MIRT306847 FYTTD1 forty-two-three domain containing 1 2 2
MIRT443764 HLF HLF, PAR bZIP transcription factor 2 2
MIRT448026 GSR glutathione-disulfide reductase 2 2
MIRT448659 NCALD neurocalcin delta 2 2
MIRT449142 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT449225 RAD51B RAD51 paralog B 2 2
MIRT462421 TWISTNB TWIST neighbor 2 2
MIRT468478 SESN3 sestrin 3 2 4
MIRT478170 DENND5B DENN domain containing 5B 2 2
MIRT478577 VSIG2 V-set and immunoglobulin domain containing 2 2 2
MIRT481300 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 16
MIRT485894 ZFP36 ZFP36 ring finger protein 2 2
MIRT497242 FITM2 fat storage inducing transmembrane protein 2 2 2
MIRT500282 ZNF703 zinc finger protein 703 2 8
MIRT509536 RSBN1L round spermatid basic protein 1 like 2 4
MIRT511835 GPATCH8 G-patch domain containing 8 2 4
MIRT522437 MON1B MON1 homolog B, secretory trafficking associated 2 2
MIRT523538 GLO1 glyoxalase I 2 4
MIRT527631 MYBPC1 myosin binding protein C, slow type 2 4
MIRT528059 OLAH oleoyl-ACP hydrolase 2 2
MIRT532549 TXNL1 thioredoxin like 1 2 2
MIRT545503 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT546724 RNF6 ring finger protein 6 2 2
MIRT546737 RNF141 ring finger protein 141 2 2
MIRT550889 ACTA1 actin, alpha 1, skeletal muscle 2 2
MIRT554180 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT555878 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT558458 DCUN1D1 defective in cullin neddylation 1 domain containing 1 2 2
MIRT560375 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT562672 AKT3 AKT serine/threonine kinase 3 2 2
MIRT563810 TUBA1B tubulin alpha 1b 2 2
MIRT564607 ZNF711 zinc finger protein 711 2 2
MIRT564881 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT566724 MSL2 MSL complex subunit 2 2 2
MIRT566900 CSRP3 cysteine and glycine rich protein 3 2 2
MIRT570002 COL1A2 collagen type I alpha 2 chain 2 2
MIRT612300 ZFP14 ZFP14 zinc finger protein 2 2
MIRT618334 ZNF813 zinc finger protein 813 2 2
MIRT627658 RSBN1 round spermatid basic protein 1 2 2
MIRT630660 PLAG1 PLAG1 zinc finger 2 2
MIRT640802 MYCL1 MYCL proto-oncogene, bHLH transcription factor 1 1
MIRT651370 ZBTB21 zinc finger and BTB domain containing 21 2 2
MIRT709227 GPSM2 G protein signaling modulator 2 2 2
MIRT712058 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT725006 ZPBP zona pellucida binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-569 Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-569 Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-569 Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (M14) (50nM)
hsa-miR-569 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (M14) (50nM)
hsa-mir-569 Fluorouracil 3385 NSC19893 approved sensitive cell line (OE19)
hsa-mir-569 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-569 Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-569 Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-569 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-569 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-569 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-569 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-569 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)

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