miRTarBase - #MIRT169899


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pre-miRNA Information
pre-miRNA hsa-let-7a-1   
Genomic Coordinates chr9: 94175957 - 94176036
Synonyms LET7A1, MIRNLET7A1, let-7a-1, MIRLET7A1
Description Homo sapiens let-7a-1 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-let-7a-3   
Genomic Coordinates chr22: 46112749 - 46112822
Synonyms LET7A3, MIRNLET7A3, let-7a-3, MIRLET7A3
Description Homo sapiens let-7a-3 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-let-7a-3p
Sequence 57| CUAUACAAUCUACUGUCUUUC |77
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 9 + 94176017 29233923 MiREDiBase
A-to-I 5 22 + 46112804 29233923 MiREDiBase
A-to-I 12 22 + 46112811 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs972845958 1 dbSNP
rs781681931 2 dbSNP
rs748585376 3 dbSNP
rs779353569 6 dbSNP
rs1198423693 8 dbSNP
rs970921980 8 dbSNP
rs372596018 9 dbSNP
rs770208205 10 dbSNP
rs1453867589 11 dbSNP
rs1399588338 15 dbSNP
rs1219969167 16 dbSNP
rs1265084977 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HBP1   
Synonyms -
Description HMG-box transcription factor 1
Transcript NM_012257   
Expression
Putative miRNA Targets on HBP1
3'UTR of HBP1
(miRNA target sites are highlighted)		 
>HBP1|NM_012257|3'UTR
   1 ACCAGGATGCTTATGTTCTTAAGTCTATATTTGCATATACATTGACTCTTGATGGAAAGACTTAAGAAGATCAAGGTCTC
  81 ACCATTTGTCCTCAATTCGTGTGACCATAAGATACTGATAGCATTGAGTCTTGAAATGATTTAATAATATGAGTGAGGAT
 161 TTGCTTTCTCCATTAGAGCATTAAGCTAAAACTATCAACATTTTAAACCAAATTGCCTTATTTTTCTTCCAAACTTCATA
 241 TATGTCTATCAGGTAATAATAGGCTTGAAAATTGATATCCTGTGGTGCTAAAGTACAGTAGAAAGAGAGGAGAAGTGTAT
 321 ACATGTTTTATTTTAAATTGTACGAAAGGGGAATTTAAAAAATATGTAACTGCTGTTTATACATTGGCTCCTTACTGCTT
 401 ATTAATCTGTATTGTACACATGATGAAATGAAGCAGAAGCTGGGAGTCGGCCTTTCCTCTAGTAACCACCACATGGCTCA
 481 GCATCTGTGCCAAACATAGGCGCTCCTAGTCTGGTCAGTGCCAAGAGGCTACCAGAACATGGGGCAGGTGGCTGGTGTTG
 561 GTGTCCCAGCCTAAGAGCCACCTGCTGCAGTTACCATGGCATGCTGAGTTGATGCACCAGGTGGCAGCAGCCATCCGTTA
 641 TTATTTCCAATGGAGACCTAGCCCAGGCCAAGGTAAAGTTAGTTAATAGCATTGGGATATAGTCACTGTAATGGTGCTAT
 721 TAACAAACAGTCAACACCATTGTATTTTTTAACTTCGTGTTCTGTATCTCCTCAGCCATGTATCTTAAATATATTTTGTC
 801 ATCATAATCTTTATGGTGGGGGCAGACTTTGCACTTACTGCAGTGCAACACTTGCACTTTAATTTTCCTCCAACTGTCTA
 881 AAATTAGAGCAAATACATTGGCAATACAGCTGCTTTTGCTCTGAGCTACAATCATGGCTTTTCATGTTACTTACCAAGTG
 961 GTGTTTCTGGTTAGGAATCACAGCTGTAAAATTGATTTCAGTTCATCACACTTCTTCATGATGTTGCCCCTAAATTTTGC
1041 ACACTATATTCTTGTATATTATTTCAAATAAATGGAAAAAAAAGTTGCTTATCTCTGAAAAAAAAAAAAAAAAAAAAAAA
1121 AAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUUCUGUCAUC-UAACAUAUc 5'
            |||| || || | |||||| 
Target 5' gaAAGAGAGGAGAAGTGTATAc 3'
 301 - 322 139.00 -13.60
2 
miRNA  3' cuuUCUGUCA----U-CUAACAUAuc 5'
             | |||||    |  |||||||  
Target 5' aacAAACAGTCAACACCATTGTATtt 3'
 722 - 747 132.00 -6.30
3 
miRNA  3' cuuUCUGUCAUC-UAAC---AUAUc 5'
             || :| ||| ||||   |||| 
Target 5' gttAGTTAATAGCATTGGGATATAg 3'
 678 - 702 114.00 -5.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
911613 344 ClinVar
358434 366 ClinVar
358435 449 ClinVar
358436 602 ClinVar
911614 618 ClinVar
911615 637 ClinVar
911616 660 ClinVar
911617 746 ClinVar
358437 808 ClinVar
908663 843 ClinVar
358438 975 ClinVar
358439 1088 ClinVar
358440 1089 ClinVar
COSN30148695 16 COSMIC
COSN30155969 49 COSMIC
COSN31540908 55 COSMIC
COSN30157727 70 COSMIC
COSN30132621 78 COSMIC
COSN30154518 81 COSMIC
COSN30539614 134 COSMIC
COSN31519578 134 COSMIC
COSN30539615 139 COSMIC
COSN31576319 148 COSMIC
COSN27901732 247 COSMIC
COSN31485796 247 COSMIC
COSN30176150 249 COSMIC
COSN31488250 275 COSMIC
COSN31547068 318 COSMIC
COSN31515346 345 COSMIC
COSN31481467 483 COSMIC
COSN31603248 718 COSMIC
COSN7919476 765 COSMIC
COSN26553478 902 COSMIC
COSN21453202 1040 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1176230094 4 dbSNP
rs761182181 7 dbSNP
rs575270872 10 dbSNP
rs1159172313 19 dbSNP
rs760187814 21 dbSNP
rs1384319631 24 dbSNP
rs769329259 28 dbSNP
rs1316131613 30 dbSNP
rs547734050 32 dbSNP
rs760018179 34 dbSNP
rs906880981 35 dbSNP
rs767877405 36 dbSNP
rs1001374263 37 dbSNP
rs1463038595 38 dbSNP
rs1320919449 44 dbSNP
rs752989307 49 dbSNP
rs987092102 54 dbSNP
rs1472441877 59 dbSNP
rs1235487368 60 dbSNP
rs908800575 60 dbSNP
rs1011398658 62 dbSNP
rs1477737867 64 dbSNP
rs1202598329 67 dbSNP
rs940154744 68 dbSNP
rs561139290 69 dbSNP
rs530266824 73 dbSNP
rs1289998120 75 dbSNP
rs550225636 77 dbSNP
rs966846011 80 dbSNP
rs1356321808 83 dbSNP
rs1291803271 89 dbSNP
rs1412138039 94 dbSNP
rs770526035 99 dbSNP
rs1351490604 100 dbSNP
rs948859334 108 dbSNP
rs1044367246 116 dbSNP
rs570071183 119 dbSNP
rs1351646152 120 dbSNP
rs1165619035 124 dbSNP
rs1404678253 125 dbSNP
rs1397096674 126 dbSNP
rs907251834 133 dbSNP
rs1437639635 141 dbSNP
rs1157775438 142 dbSNP
rs1411617025 142 dbSNP
rs1000038820 144 dbSNP
rs1250821099 144 dbSNP
rs1002830899 145 dbSNP
rs1179511344 147 dbSNP
rs1402306368 147 dbSNP
rs1056277387 148 dbSNP
rs746984593 150 dbSNP
rs892397863 151 dbSNP
rs1271746494 152 dbSNP
rs1009791925 154 dbSNP
rs1022152894 166 dbSNP
rs1436540914 174 dbSNP
rs1330180898 185 dbSNP
rs1305228082 191 dbSNP
rs1288149110 193 dbSNP
rs140869666 195 dbSNP
rs1041263171 196 dbSNP
rs562248212 199 dbSNP
rs996635341 208 dbSNP
rs191952814 213 dbSNP
rs1322399392 214 dbSNP
rs1207481690 215 dbSNP
rs1288333721 218 dbSNP
rs907598098 221 dbSNP
rs1410903911 233 dbSNP
rs954989032 241 dbSNP
rs1451158477 244 dbSNP
rs781036742 248 dbSNP
rs529549920 249 dbSNP
rs1045903251 254 dbSNP
rs908767852 255 dbSNP
rs1211078883 261 dbSNP
rs1465773599 264 dbSNP
rs1267866054 269 dbSNP
rs1456564176 272 dbSNP
rs774715082 273 dbSNP
rs974634233 275 dbSNP
rs1302164833 277 dbSNP
rs1366158552 279 dbSNP
rs571520604 283 dbSNP
rs1299957655 288 dbSNP
rs1435684536 289 dbSNP
rs1055630710 293 dbSNP
rs765212427 300 dbSNP
rs1359538583 305 dbSNP
rs1174856123 307 dbSNP
rs1412935089 307 dbSNP
rs1391446726 308 dbSNP
rs1405473560 313 dbSNP
rs1011349378 316 dbSNP
rs375479179 318 dbSNP
rs1041530723 323 dbSNP
rs772552151 323 dbSNP
rs1185295427 326 dbSNP
rs948812373 331 dbSNP
rs1484410307 332 dbSNP
rs534075932 344 dbSNP
rs554148267 345 dbSNP
rs1346044938 353 dbSNP
rs938656791 353 dbSNP
rs1229315949 360 dbSNP
rs1364552082 360 dbSNP
rs1445500121 364 dbSNP
rs773755170 366 dbSNP
rs1802028 367 dbSNP
rs1432453111 370 dbSNP
rs1336785949 374 dbSNP
rs111247485 375 dbSNP
rs1168672810 381 dbSNP
rs1428469988 384 dbSNP
rs892359660 384 dbSNP
rs1370862292 386 dbSNP
rs1241595606 391 dbSNP
rs573763819 400 dbSNP
rs1356217564 401 dbSNP
rs1257265413 403 dbSNP
rs1233991836 404 dbSNP
rs1484807365 408 dbSNP
rs1009517226 410 dbSNP
rs1206152323 414 dbSNP
rs71566719 416 dbSNP
rs1029235773 417 dbSNP
rs1341486292 417 dbSNP
rs761053124 419 dbSNP
rs144869808 421 dbSNP
rs903726551 423 dbSNP
rs996687555 430 dbSNP
rs1028044889 434 dbSNP
rs1352106384 436 dbSNP
rs955123981 442 dbSNP
rs556191560 443 dbSNP
rs147954001 449 dbSNP
rs751654417 450 dbSNP
rs1439380668 456 dbSNP
rs1164536325 461 dbSNP
rs753846764 463 dbSNP
rs544557530 465 dbSNP
rs1015286259 470 dbSNP
rs961921352 473 dbSNP
rs1185089051 477 dbSNP
rs1164657600 486 dbSNP
rs1474396735 488 dbSNP
rs1414681987 503 dbSNP
rs1183115200 512 dbSNP
rs1236855460 515 dbSNP
rs974389117 518 dbSNP
rs1473053746 534 dbSNP
rs1211769417 538 dbSNP
rs1488762469 540 dbSNP
rs920174050 545 dbSNP
rs1166476456 552 dbSNP
rs755241520 553 dbSNP
rs1231396191 559 dbSNP
rs1330892357 561 dbSNP
rs1420930278 565 dbSNP
rs928407669 565 dbSNP
rs936996365 569 dbSNP
rs1324942368 571 dbSNP
rs1386916863 573 dbSNP
rs564539024 577 dbSNP
rs1055413755 583 dbSNP
rs980253424 591 dbSNP
rs1391250134 595 dbSNP
rs1160430395 597 dbSNP
rs886061867 602 dbSNP
rs765487365 604 dbSNP
rs914259199 606 dbSNP
rs1398147739 609 dbSNP
rs1433790902 611 dbSNP
rs1252478609 612 dbSNP
rs762556812 614 dbSNP
rs183289135 618 dbSNP
rs938792917 622 dbSNP
rs533473434 624 dbSNP
rs913267653 630 dbSNP
rs551727433 637 dbSNP
rs1204395255 638 dbSNP
rs1043613478 641 dbSNP
rs902975377 642 dbSNP
rs1276186975 645 dbSNP
rs139428063 651 dbSNP
rs1329962709 656 dbSNP
rs1300675969 657 dbSNP
rs1040449537 658 dbSNP
rs932447330 665 dbSNP
rs1368039380 666 dbSNP
rs1049611446 670 dbSNP
rs6952928 671 dbSNP
rs530284324 674 dbSNP
rs1383281252 675 dbSNP
rs1296596701 676 dbSNP
rs1466776631 686 dbSNP
rs996160715 690 dbSNP
rs1028975136 691 dbSNP
rs543667847 692 dbSNP
rs887789551 697 dbSNP
rs563759284 700 dbSNP
rs1006438718 707 dbSNP
rs890863976 708 dbSNP
rs1280507715 709 dbSNP
rs1200644972 713 dbSNP
rs532499495 720 dbSNP
rs539124790 722 dbSNP
rs962230103 722 dbSNP
rs1365296603 723 dbSNP
rs1198532541 725 dbSNP
rs187030164 726 dbSNP
rs1277575022 730 dbSNP
rs566069137 731 dbSNP
rs1008014170 735 dbSNP
rs1325011712 736 dbSNP
rs757140171 736 dbSNP
rs1035429276 738 dbSNP
rs1396808582 739 dbSNP
rs958427593 741 dbSNP
rs1171842964 743 dbSNP
rs1431633360 744 dbSNP
rs1390882714 745 dbSNP
rs190095596 746 dbSNP
rs1474407892 747 dbSNP
rs1238965162 749 dbSNP
rs182338996 757 dbSNP
rs1485136301 768 dbSNP
rs1254870859 769 dbSNP
rs567466802 779 dbSNP
rs1206865392 781 dbSNP
rs1342194542 781 dbSNP
rs947054835 782 dbSNP
rs977361633 786 dbSNP
rs1338076422 788 dbSNP
rs1193708106 794 dbSNP
rs924554793 795 dbSNP
rs1374462186 799 dbSNP
rs1355231363 807 dbSNP
rs10699573 808 dbSNP
rs192948081 814 dbSNP
rs1355156032 816 dbSNP
rs1027209832 823 dbSNP
rs1408127330 835 dbSNP
rs1415952478 839 dbSNP
rs530897270 843 dbSNP
rs1474723203 855 dbSNP
rs1415420149 859 dbSNP
rs1183847504 861 dbSNP
rs1483203480 868 dbSNP
rs1231797727 869 dbSNP
rs1201904121 871 dbSNP
rs536406901 874 dbSNP
rs1292565635 877 dbSNP
rs781682808 882 dbSNP
rs980222657 888 dbSNP
rs1339034006 895 dbSNP
rs1035849823 897 dbSNP
rs1334559304 903 dbSNP
rs932023661 905 dbSNP
rs1230435797 914 dbSNP
rs1374405313 917 dbSNP
rs556088585 940 dbSNP
rs569879796 941 dbSNP
rs149977658 949 dbSNP
rs1440024081 950 dbSNP
rs1296312837 955 dbSNP
rs568858422 962 dbSNP
rs1351697023 969 dbSNP
rs960108609 972 dbSNP
rs1328433197 973 dbSNP
rs115287891 975 dbSNP
rs913312889 993 dbSNP
rs1406879726 1003 dbSNP
rs1472709002 1003 dbSNP
rs947378063 1006 dbSNP
rs1175126221 1008 dbSNP
rs778274629 1011 dbSNP
rs1246808587 1020 dbSNP
rs898096015 1031 dbSNP
rs367826914 1047 dbSNP
rs979187673 1050 dbSNP
rs925203343 1057 dbSNP
rs1348390072 1058 dbSNP
rs1271644076 1066 dbSNP
rs1003147034 1076 dbSNP
rs1035794232 1076 dbSNP
rs932583060 1077 dbSNP
rs886061868 1088 dbSNP
rs886061869 1089 dbSNP
rs1491187157 1090 dbSNP
rs958874260 1091 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 26959.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000222574.4 | 3UTR | CCCCUAAAUUUUGCACACUAUAUUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000222574.4 | 3UTR | CCCCUAAAUUUUGCACACUAUAUUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000222574.4 | 3UTR | CCCCUAAAUUUUGCACACUAUAUUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000222574.4 | 3UTR | UUGCCCCUAAAUUUUGCACACUAUAUUCUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PRAD -0.301 0.02 -0.325 0.01 50 Click to see details
KIRP -0.362 0.02 -0.419 0.01 32 Click to see details
LIHC -0.265 0.03 -0.275 0.03 49 Click to see details
STAD -0.263 0.07 -0.241 0.09 32 Click to see details
BLCA -0.339 0.08 -0.282 0.13 18 Click to see details
KIRC -0.167 0.09 -0.156 0.1 68 Click to see details
ESCA 0.373 0.13 0.436 0.09 11 Click to see details
LUAD -0.35 0.13 -0.420 0.09 12 Click to see details
COAD -0.669 0.17 -1.000 0.5 4 Click to see details
HNSC -0.142 0.18 -0.163 0.15 42 Click to see details
PCPG 0.823 0.19 1.000 0.5 3 Click to see details
CESC -0.815 0.2 -1.000 0.5 3 Click to see details
THCA -0.111 0.2 -0.262 0.02 59 Click to see details
UCEC -0.187 0.22 -0.072 0.38 19 Click to see details
CHOL 0.256 0.25 0.533 0.07 9 Click to see details
KICH 0.134 0.26 0.120 0.28 25 Click to see details
BRCA 0.056 0.31 0.051 0.32 84 Click to see details
PAAD 0.32 0.34 -0.200 0.4 4 Click to see details
LUSC -0.047 0.39 -0.053 0.38 38 Click to see details
LUSC -0.047 0.39 -0.053 0.38 38 Click to see details
121 hsa-let-7a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038998 ARMC8 armadillo repeat containing 8 1 1
MIRT038999 SETD4 SET domain containing 4 1 1
MIRT039000 BTF3 basic transcription factor 3 1 1
MIRT039001 MIPOL1 mirror-image polydactyly 1 1 1
MIRT039002 TRIM33 tripartite motif containing 33 1 1
MIRT039003 CS citrate synthase 1 1
MIRT039004 SENP7 SUMO1/sentrin specific peptidase 7 1 1
MIRT055418 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT057681 LCOR ligand dependent nuclear receptor corepressor 2 8
MIRT061351 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT062174 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT071813 RNF11 ring finger protein 11 2 2
MIRT091374 EIF4A2 eukaryotic translation initiation factor 4A2 2 2
MIRT095107 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT098814 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT109534 KLHL15 kelch like family member 15 2 4
MIRT120263 GSK3B glycogen synthase kinase 3 beta 2 2
MIRT149839 LDLR low density lipoprotein receptor 2 6
MIRT164519 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165879 CREBRF CREB3 regulatory factor 2 2
MIRT169899 HBP1 HMG-box transcription factor 1 2 4
MIRT182779 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT193466 RORA RAR related orphan receptor A 2 2
MIRT226421 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT334410 CREBZF CREB/ATF bZIP transcription factor 2 6
MIRT338286 SYF2 SYF2 pre-mRNA splicing factor 2 2
MIRT361627 TES testin LIM domain protein 2 2
MIRT406687 ZNF181 zinc finger protein 181 2 2
MIRT407768 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT449468 HAT1 histone acetyltransferase 1 2 2
MIRT467110 SRI sorcin 2 2
MIRT475099 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 6
MIRT481671 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT493061 MTFR1 mitochondrial fission regulator 1 2 2
MIRT497923 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498202 ACVR2B activin A receptor type 2B 2 2
MIRT503391 ASB11 ankyrin repeat and SOCS box containing 11 2 6
MIRT503862 UBXN2B UBX domain protein 2B 2 2
MIRT504368 ARID1B AT-rich interaction domain 1B 2 4
MIRT504991 ZNF652 zinc finger protein 652 2 2
MIRT505754 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT518102 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2 6
MIRT521930 PHF8 PHD finger protein 8 2 4
MIRT522139 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522401 MYADM myeloid associated differentiation marker 2 4
MIRT523593 FZD5 frizzled class receptor 5 2 4
MIRT523944 E2F8 E2F transcription factor 8 2 4
MIRT524355 CREB1 cAMP responsive element binding protein 1 2 2
MIRT525140 ZNF256 zinc finger protein 256 2 2
MIRT527070 ABCC4 ATP binding cassette subfamily C member 4 2 2
MIRT527486 OCIAD1 OCIA domain containing 1 2 2
MIRT528129 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT530528 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT531270 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538898 BRI3BP BRI3 binding protein 2 2
MIRT541371 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT541526 MGAT4C MGAT4 family member C 2 2
MIRT543776 RBM12B RNA binding motif protein 12B 2 4
MIRT543946 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545156 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545848 ZNF264 zinc finger protein 264 2 4
MIRT546064 VEZF1 vascular endothelial zinc finger 1 2 2
MIRT546481 SLC16A14 solute carrier family 16 member 14 2 4
MIRT551835 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT551901 ACP1 acid phosphatase 1, soluble 2 2
MIRT552490 ZNF136 zinc finger protein 136 2 2
MIRT554206 SLC35A5 solute carrier family 35 member A5 2 2
MIRT554295 SIPA1L2 signal induced proliferation associated 1 like 2 2 2
MIRT555765 PCTP phosphatidylcholine transfer protein 2 2
MIRT558315 DSG2 desmoglein 2 2 2
MIRT563147 NOLC1 nucleolar and coiled-body phosphoprotein 1 2 2
MIRT566464 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT567322 HMGB2 high mobility group box 2 2 2
MIRT567738 DLX2 distal-less homeobox 2 2 2
MIRT567892 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT570087 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571136 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT573534 MDM2 MDM2 proto-oncogene 2 2
MIRT574465 RPS16 ribosomal protein S16 2 2
MIRT574998 Phka1 phosphorylase kinase alpha 1 2 3
MIRT610202 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612926 GPRIN3 GPRIN family member 3 2 2
MIRT615027 DUSP6 dual specificity phosphatase 6 2 2
MIRT617200 GREM1 gremlin 1, DAN family BMP antagonist 2 2
MIRT628720 ZNF585A zinc finger protein 585A 2 2
MIRT641491 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641663 PAPOLG poly(A) polymerase gamma 2 2
MIRT642216 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT654589 PURA purine rich element binding protein A 2 2
MIRT656136 MSH6 mutS homolog 6 2 2
MIRT656899 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660136 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660861 AFAP1 actin filament associated protein 1 2 2
MIRT676849 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681479 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682259 RS1 retinoschisin 1 2 2
MIRT685602 MYOM2 myomesin 2 2 2
MIRT686943 SFT2D3 SFT2 domain containing 3 2 2
MIRT694302 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694407 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT697280 ZNF800 zinc finger protein 800 2 2
MIRT698414 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT698989 SPAG9 sperm associated antigen 9 2 2
MIRT699766 SEMA4D semaphorin 4D 2 2
MIRT699928 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT702113 MBNL1 muscleblind like splicing regulator 1 2 2
MIRT702373 KLF10 Kruppel like factor 10 2 2
MIRT702646 ITGA3 integrin subunit alpha 3 2 2
MIRT705713 ANAPC16 anaphase promoting complex subunit 16 2 2
MIRT717925 ZNF546 zinc finger protein 546 2 2
MIRT720839 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT725033 NDUFAF7 NADH:ubiquinone oxidoreductase complex assembly factor 7 2 2
MIRT731448 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 1 1
MIRT733217 CCNG1 cyclin G1 2 0
MIRT734887 LIN28B lin-28 homolog B 1 0
MIRT735276 HMGA2 high mobility group AT-hook 2 2 0
MIRT735727 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 3 0
MIRT736087 RCVRN recoverin 1 0
MIRT736088 RHO rhodopsin 1 0
MIRT736103 TLR7 toll like receptor 7 1 0
MIRT736607 TPO thyroid peroxidase 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
let-7a Caudatin NULL 21633059 Quantitative real-time PCR gastric carcinoma cell lines 23708208 2013 up-regualted
let-7a XMD8-92 NULL 46843772 Microarray pancreatic ductal adenocarcinoma cell 24880079 2014 up-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Northern blot breast cancer cell line SKBr3 16452180 2006 down-regulated
let-7a Trichostatin A (TSA) NULL 444732 Microarray human pancreatic cancer cell line BxPC-3 19112422 2009 down-regulated
let-7a 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7a Etoposide approved 36462 Microarray Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Etoposide approved 36462 Quantitative real-time PCR Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Polylysine NULL 162282 Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Trypaflavine NULL NULL Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
let-7a Enoxacin approved 3229 Northern blot HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR MCF-7 human mammary cancer cell line 21368581 2011 up-regulated
let-7a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
let-7a Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a CDF(analogues of curcumin) NULL NULL Quantitative real-time PCR pancreatic cancer cells 22108826 2012 up-regulated
let-7a Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 down-regulated
let-7a Curcumin NULL 969516 Quantitative real-time PCR esophageal cancer cells 22363450 2012 up-regulated
let-7a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 up-regulated
let-7a Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
let-7a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 up-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice lung 20145010 2010 down-regulated
let-7a Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice lung 20145010 2010 up-regulated
let-7a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
let-7a Dexamethasone approved 5743 Quantitative real-time PCR primary rat thymocytes 20847043 2010 down-regulated
let-7a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
let-7a Hydroxychloroquine approved 3652 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
let-7a Prednisone approved 5865 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-let-7a-3p Gemcitabine 60750 NSC613327 approved resistant High Cholangiocarcinoma cell line (HuCCT1, HuH28)
hsa-let-7a-3p Docetaxel 148124 NSC628503 approved sensitive High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-let-7a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-let-7a-3p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-let-7a-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-let-7a-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-let-7a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-let-7a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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