miRTarBase - #MIRT173040


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pre-miRNA Information
pre-miRNA hsa-mir-4436b-1   
Genomic Coordinates chr2: 110086433 - 110086523
Description Homo sapiens miR-4436b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4436b-2   
Genomic Coordinates chr2: 110284853 - 110284943
Description Homo sapiens miR-4436b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4436b-3p
Sequence 60| CAGGGCAGGAAGAAGUGGACAA |81
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760150076 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol YTHDF3   
Synonyms -
Description YTH N6-methyladenosine RNA binding protein 3
Transcript NM_152758   
Expression
Putative miRNA Targets on YTHDF3
3'UTR of YTHDF3
(miRNA target sites are highlighted)		 
>YTHDF3|NM_152758|3'UTR
   1 CCGTATGAAGATGTCCTGTTAAATTTACAACACTAACGATGTAGACTCTGGAAATGCCTAATAAGTCAAAGAAGACGTAT
  81 TAAAGCTCTTTTCTGCTTAAGGTGACATCTTTGAACACTTTAACACAAAGTTGACTCTTCTCGTAATGGTTTTCATCAGC
 161 GCATCTGCCCTTATACTCTTCACCAAACACACTTGAGAACTGTAACTTCGTCAAGCACTTTCTGTCCTGAAGCTTTTACC
 241 AGTATCTGCTGTCTTTTGTAATTATGCATCCTAGCTAAGGCACAGAAGACTGAATGAATGCAAGGATTCATTAACTCTTT
 321 GAATTTGTTAAATACTAACAGTTAACCATTAGAAGTGGTTCAATGATGTAAGAGTCACACTGCTTCAACTTTTTCTTTGT
 401 TGTAGTTTTTAAATTGTCGATTTTTAGCTATTTGACAGATTAAAAGCAAAATAATCATGCCATATTTAGTCCTGGAGTTC
 481 AAGTCTAAATGTTGATGTGAAAAATTATTGTAGTAAACTTTTAATATGGCAAAGCAACCTTAAGCTCTATTTTAGCCAAA
 561 TGAAACATAATCTGAAATTATATTAGAACATTTCCCTTGTCTTCAAACTGTTTGGTGTAACAGAATATTGATATGCAGCT
 641 TGGTGGATTTCACCAGTTAATGCACATTCTTCTTCCCTCCTCCCCCCATTAATATGTATACTGAAAAATGTGCATTTGTC
 721 TGAGGAATTATTTTGTTTGCTACCACTTAATGAATCTCAAAATTTTGAGTAAATGTACCTCAGTCTAATCAGACTTTTTA
 801 TGACCTTTATAACTACATTTAAAACCCTTAATTCCTATTTCTGGGTGTTTGCGAGCCTGATTGCTATCATGAAGTAAAAA
 881 TTTATTACTCTAGGTATTCACTAGCTAAATAAACATAGTTCTTGTTTAGCAAGCATATGTTGTTCCTCAGCTCTTTTCTC
 961 CAGCTTTTGCAGTGTCCTGGCATCCTTAAAATACTTTGAAAATATGGCCTTGATCCATGGATTAAATCAGTATCTAAGTG
1041 AATGTGTTGATGTTTTATTGATCAGATCTATATAAGTGGGAATACAGCATATATCTGGATATTCTTATAGTTATCTTTTT
1121 AACATCTTATTTTTTTCATTAATTACATATCAACATTAATTTTGTATCTTGAAGCAAATTGATTTTGTATAATTAAATGT
1201 GTCAAGCATCTGTATTAATTGATTTGATGGCATAAGGTTATGAAAATAATGTACTGCCCCATGTATTACTGTTCCAAAAG
1281 GAGAAAGCTATGTAGAAAGATACATTAAGGGTGAAAATAGCAATACAGTAGATTTGAATACCTTGATGTTTTGCATTACT
1361 TCATTTATGTTTACATCATGTTTAGAAATGTTTTCATTTACTGTGGTCTTTGGTCACTTCAGCTCAAAGACCTAGTGATG
1441 GATATTTCTTTGAGGCTTTCATTTATATAATTTTATTTTGTACAATGTTTTTTTTAAATGTGCAAATACTGTATTCAAGT
1521 GAAAAAAATACAGTATTTGTAGATAACCATAGCTACTACACAGTTCTTCGGTAGTCCCAGTGTAGTTATATCAGTGTTTA
1601 CTGAAGGGAACATCAAAATATTAATGGTATATTATAAAATAAAGACTTTCTTAAAGGAAAATTGCACCTATTTTACCTTT
1681 TTAAGAGTAAGCCATGAAATCTTGTAACATGTCTCTTAACTATTTATAATGAAAAGTGGCATTTGGGTATAGTCACCACA
1761 GCAATGTTCTACATCCCTAAGATTATCTAGGTAGGACATGTCAAAGATGACTGTTGTCATTCTGGAGGTCCTATTAGAGA
1841 ATATTATAAAAGGGTGACCTTGTAGGAAGGATCTGAGTCCTCCCCCTGAGGTTCTCTTTTTCTTGGTGCTTTATTAGCAA
1921 CTCTGGATATTTTTATAAAACTAGTTACATTATAAACGGTTTCAAACATGTTTAATTTACATTAGGTTTTTATGTAAGAG
2001 TGTCATGGAAGCACTCAGCAAGCAGGCTGATTGCAATAGACTCAGACATGCGAATAAATGTAATTGAGAGTCTATTCATG
2081 GTGAGGAGTACATCCCAGTGCCTTTAACCTGGATTTCTAATCTTAAGTGAAATGGGTGCAGCATTCCTTTGGAAAAAAAA
2161 ATCTTTTTATTTTCAAGTGATAATTTTGTGTTTTTCTCATATAAGTTTTCTCCAGAGCACCCACCTTCTCTTCCTTCTTG
2241 GTCTGTCATTATATTGCAAAATATTTTTCCTCTGAATGAAATTATCACAGGTTGTCTCAAGCACAACCAACTGAATGTCT
2321 CTTAACTGTGGGGACCAAAAGGGAGAGAGCCTGGGGTCTACAAGAGGAGACACATCATCAAATGTTTGAATGATCACAAA
2401 TTAAGACATTATCAGCCCAGTAAATTTCTTGCTTAATGTTTTTCCAAGTTCTGGCTTGAATATTTCTTATTAAAGCTATC
2481 TTATGTGGGTATTTTATTTTGAAAGGTATTATAGTTTGTATATTTAACAGTAAGGAGGAAACTGTAACCAAAATTAGTAT
2561 TTCTCTATACGTATTGGTACTTGAAGATTCCTTTCAAAAGAAATCCAGCGTTTTCCTAATTTTAGTACTTAATTTCTCTT
2641 TTTAATTTAAGTGATCTTTCTAATTCGAAAGCTGTGTTCTTTTTGAATACCGTGCATGGGGGTTAAGCTGATGTTAAAAC
2721 AGTTTGCAATAAAAAAAAATGAATCAGCTTAAGTCATTTAATCATTTCAAGTGCATTCTGCATCCTTTAAAAATAAGTTT
2801 AAGAAATTTAAGAGAATTGTGTTTTCATTAAGTTTTGCATATCTTTTGTTATGCCATGTAAATTCCCTTTTTCGTATGAT
2881 TAAAGGAAGGTTATGATAAAATGATTAGTTCATTTACATTCACTTGTAGCAATTACATGAGAATTTGAATTTTGTCGTGT
2961 TTGGGTTTGTTCATTCCTGTGAATGATGGTACAGTTAGGTGAGATTTTCTGTTATGGTACCCAAACTCACCATTTGGTCC
3041 TCTTTAATCTTTGAGGGTTTCAATAAAAATTGTTCACTCATAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaCAGGUGAAGAAGGACGGGAc 5'
            ||| |   |||:|||:||| 
Target 5' tcGTCAAGCACTTTCTGTCCTg 3'
 208 - 229 148.00 -21.40
2 
miRNA  3' aaCAGGUGAAGAAG----GACGGGAc 5'
            ||:: | ||  |    ||||||| 
Target 5' tgGTTTTCATCAGCGCATCTGCCCTt 3'
 147 - 172 146.00 -13.90
3 
miRNA  3' aacAGGUG-AAGAAGGACGGGAc 5'
             | ||| ||||| || |||| 
Target 5' taaTGCACATTCTT-CTTCCCTc 3'
 658 - 679 134.00 -16.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30754440 3 COSMIC
COSN18733185 4 COSMIC
COSN31582161 12 COSMIC
COSN30166258 26 COSMIC
COSN31529255 39 COSMIC
COSN30515844 40 COSMIC
COSN31545439 42 COSMIC
COSN30499424 43 COSMIC
COSN27005428 62 COSMIC
COSN23017228 72 COSMIC
COSN31605668 78 COSMIC
COSN30159955 179 COSMIC
COSN30166263 223 COSMIC
COSN5237234 400 COSMIC
COSN16128136 454 COSMIC
COSN25427047 468 COSMIC
COSN16128909 652 COSMIC
COSN9460298 965 COSMIC
COSN19409965 981 COSMIC
COSN26595919 994 COSMIC
COSN31521379 1086 COSMIC
COSN31530623 1227 COSMIC
COSN17076150 1282 COSMIC
COSN31543690 1487 COSMIC
COSN5113814 1499 COSMIC
COSN31548263 1567 COSMIC
COSN16755488 1904 COSMIC
COSN31545105 1956 COSMIC
COSN28236553 1993 COSMIC
COSN5685654 2011 COSMIC
COSN31556763 2162 COSMIC
COSN16129660 2231 COSMIC
COSN24142013 2238 COSMIC
COSN31570239 2261 COSMIC
COSN26565462 2314 COSMIC
COSN26881741 2389 COSMIC
COSN31582516 2424 COSMIC
COSN18955174 2571 COSMIC
COSN26831938 2610 COSMIC
COSN30164283 2611 COSMIC
COSN31514073 2667 COSMIC
COSN8519222 2701 COSMIC
COSN31568490 2733 COSMIC
COSN20105540 2740 COSMIC
COSN16132081 2779 COSMIC
COSN4941155 2785 COSMIC
COSN31660618 2868 COSMIC
COSN31548700 2942 COSMIC
COSN31536493 2946 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs778757694 2 dbSNP
rs750253215 3 dbSNP
rs755196711 4 dbSNP
rs983266523 6 dbSNP
rs1468797716 7 dbSNP
rs781441216 13 dbSNP
rs748176401 14 dbSNP
rs146849358 15 dbSNP
rs778184400 20 dbSNP
rs199808565 30 dbSNP
rs1265887089 31 dbSNP
rs200422168 32 dbSNP
rs1379149512 33 dbSNP
rs1401654837 35 dbSNP
rs749806210 38 dbSNP
rs771396344 39 dbSNP
rs1392837904 49 dbSNP
rs915897571 51 dbSNP
rs370659476 55 dbSNP
rs375726695 62 dbSNP
rs1276441672 63 dbSNP
rs1043707654 69 dbSNP
rs1296405246 72 dbSNP
rs1368190002 76 dbSNP
rs183470546 77 dbSNP
rs188808956 78 dbSNP
rs1391319693 80 dbSNP
rs1305082297 84 dbSNP
rs1010534939 86 dbSNP
rs1389854301 89 dbSNP
rs1169390151 94 dbSNP
rs539771813 110 dbSNP
rs1376235141 113 dbSNP
rs1198816910 116 dbSNP
rs756385909 119 dbSNP
rs780221226 121 dbSNP
rs1288644487 125 dbSNP
rs1452736271 131 dbSNP
rs1053209609 135 dbSNP
rs140573298 136 dbSNP
rs987203310 138 dbSNP
rs1247704492 139 dbSNP
rs1481785880 139 dbSNP
rs1008582567 143 dbSNP
rs193220472 144 dbSNP
rs1346136808 145 dbSNP
rs965214085 146 dbSNP
rs964361094 154 dbSNP
rs1408082902 156 dbSNP
rs1369961901 159 dbSNP
rs975041002 161 dbSNP
rs1414844797 162 dbSNP
rs1400296816 164 dbSNP
rs534162407 176 dbSNP
rs920806005 178 dbSNP
rs555973825 187 dbSNP
rs765140183 193 dbSNP
rs1027988749 194 dbSNP
rs574256714 196 dbSNP
rs866253450 197 dbSNP
rs1180570487 203 dbSNP
rs1471333658 210 dbSNP
rs1250369008 218 dbSNP
rs182662640 225 dbSNP
rs950661293 232 dbSNP
rs544931225 242 dbSNP
rs1199729838 243 dbSNP
rs983726192 250 dbSNP
rs1285128968 254 dbSNP
rs556849073 265 dbSNP
rs1226448096 274 dbSNP
rs1349986620 276 dbSNP
rs950160934 285 dbSNP
rs1280252277 288 dbSNP
rs1388794612 292 dbSNP
rs1046218307 293 dbSNP
rs1325266423 295 dbSNP
rs1338989351 296 dbSNP
rs906376965 303 dbSNP
rs1350321600 310 dbSNP
rs1470511371 312 dbSNP
rs960137323 314 dbSNP
rs992932299 319 dbSNP
rs145709036 322 dbSNP
rs200482681 330 dbSNP
rs1286322076 335 dbSNP
rs1413310085 336 dbSNP
rs948729681 339 dbSNP
rs544981437 343 dbSNP
rs926230021 351 dbSNP
rs767089942 354 dbSNP
rs1353790145 357 dbSNP
rs754956882 364 dbSNP
rs1206557939 367 dbSNP
rs1328457724 374 dbSNP
rs560026648 376 dbSNP
rs1284853526 378 dbSNP
rs1225607809 379 dbSNP
rs1376987594 380 dbSNP
rs1283838100 381 dbSNP
rs1453593756 389 dbSNP
rs1010827654 393 dbSNP
rs1020658167 394 dbSNP
rs966355951 397 dbSNP
rs1346374720 404 dbSNP
rs762710471 415 dbSNP
rs187781726 419 dbSNP
rs1203470864 420 dbSNP
rs527360662 431 dbSNP
rs1162315954 437 dbSNP
rs1473221972 439 dbSNP
rs964910025 442 dbSNP
rs1186905352 446 dbSNP
rs1186506642 462 dbSNP
rs994951674 463 dbSNP
rs1027314377 465 dbSNP
rs759475593 480 dbSNP
rs1156930823 489 dbSNP
rs886386238 492 dbSNP
rs1163985990 493 dbSNP
rs542289494 495 dbSNP
rs920757008 503 dbSNP
rs960544625 508 dbSNP
rs1428816096 509 dbSNP
rs1291164823 514 dbSNP
rs560766852 516 dbSNP
rs376017288 520 dbSNP
rs952336438 527 dbSNP
rs1389447487 528 dbSNP
rs1023092648 540 dbSNP
rs1302043063 541 dbSNP
rs1424727598 553 dbSNP
rs970158067 563 dbSNP
rs983648757 566 dbSNP
rs191892622 569 dbSNP
rs796390364 573 dbSNP
rs1166259790 577 dbSNP
rs1427721894 579 dbSNP
rs925957672 582 dbSNP
rs1188245405 587 dbSNP
rs950025211 589 dbSNP
rs1246039123 590 dbSNP
rs934633001 594 dbSNP
rs368151830 596 dbSNP
rs1272767728 602 dbSNP
rs989034520 607 dbSNP
rs912112667 609 dbSNP
rs981566371 611 dbSNP
rs138190055 614 dbSNP
rs372368052 635 dbSNP
rs1055409416 638 dbSNP
rs1284479656 640 dbSNP
rs1405038369 642 dbSNP
rs1366833780 643 dbSNP
rs1338255120 652 dbSNP
rs893626956 663 dbSNP
rs930400078 667 dbSNP
rs1172337725 673 dbSNP
rs1431223016 678 dbSNP
rs1246353094 683 dbSNP
rs1049229943 684 dbSNP
rs946647590 686 dbSNP
rs771813282 687 dbSNP
rs1481110938 689 dbSNP
rs1253279957 696 dbSNP
rs1208549894 699 dbSNP
rs902200286 701 dbSNP
rs1311909302 712 dbSNP
rs1264323123 713 dbSNP
rs1225840460 721 dbSNP
rs564708085 726 dbSNP
rs1285962477 728 dbSNP
rs1008941296 731 dbSNP
rs1034935873 738 dbSNP
rs571202521 742 dbSNP
rs1018705668 747 dbSNP
rs1012119186 749 dbSNP
rs1023451890 755 dbSNP
rs900284402 765 dbSNP
rs1409630345 769 dbSNP
rs1277261201 770 dbSNP
rs970571334 775 dbSNP
rs995935631 783 dbSNP
rs978887125 798 dbSNP
rs1027801921 807 dbSNP
rs767586247 812 dbSNP
rs952200101 814 dbSNP
rs184146245 817 dbSNP
rs1264105188 819 dbSNP
rs551735688 823 dbSNP
rs1205941092 827 dbSNP
rs912186188 833 dbSNP
rs149557117 838 dbSNP
rs1444146979 840 dbSNP
rs1237705406 842 dbSNP
rs1316925167 847 dbSNP
rs1308724448 848 dbSNP
rs1393887981 853 dbSNP
rs974910985 854 dbSNP
rs1247601999 860 dbSNP
rs1337204410 862 dbSNP
rs922107413 866 dbSNP
rs971423291 870 dbSNP
rs765811774 873 dbSNP
rs1157860928 880 dbSNP
rs930785805 883 dbSNP
rs1365563519 885 dbSNP
rs1048819045 893 dbSNP
rs534322340 902 dbSNP
rs555863195 906 dbSNP
rs1243956253 908 dbSNP
rs907585182 911 dbSNP
rs940376749 915 dbSNP
rs1447937628 925 dbSNP
rs1261654305 936 dbSNP
rs927306928 943 dbSNP
rs1166464654 949 dbSNP
rs1391839414 953 dbSNP
rs187682591 955 dbSNP
rs866012002 962 dbSNP
rs1171861353 975 dbSNP
rs1243109893 983 dbSNP
rs1358357148 986 dbSNP
rs1315305869 998 dbSNP
rs1247907368 1006 dbSNP
rs896430931 1018 dbSNP
rs1399993702 1031 dbSNP
rs1382674423 1034 dbSNP
rs990239643 1045 dbSNP
rs1397216374 1050 dbSNP
rs1387013200 1054 dbSNP
rs1336854163 1057 dbSNP
rs915092704 1057 dbSNP
rs1012151949 1059 dbSNP
rs1424089466 1063 dbSNP
rs946511785 1071 dbSNP
rs1165637734 1073 dbSNP
rs538436814 1077 dbSNP
rs1432525563 1081 dbSNP
rs561761571 1086 dbSNP
rs1343237739 1087 dbSNP
rs1001073266 1088 dbSNP
rs1265867415 1089 dbSNP
rs1433821257 1090 dbSNP
rs556936616 1112 dbSNP
rs956122676 1115 dbSNP
rs1010227555 1116 dbSNP
rs1337241718 1123 dbSNP
rs1347791604 1126 dbSNP
rs1269422766 1127 dbSNP
rs1201081965 1129 dbSNP
rs1328193191 1130 dbSNP
rs1299015794 1137 dbSNP
rs989474181 1137 dbSNP
rs944632279 1139 dbSNP
rs1366215031 1140 dbSNP
rs1305217622 1144 dbSNP
rs756932072 1151 dbSNP
rs1168912169 1152 dbSNP
rs1463699387 1155 dbSNP
rs1040484289 1166 dbSNP
rs900146467 1169 dbSNP
rs1190821018 1175 dbSNP
rs1248884171 1176 dbSNP
rs1428832183 1178 dbSNP
rs975044073 1181 dbSNP
rs1199256479 1183 dbSNP
rs1479838050 1190 dbSNP
rs1197930644 1191 dbSNP
rs996357030 1200 dbSNP
rs1200925302 1203 dbSNP
rs1435772935 1206 dbSNP
rs1271841219 1211 dbSNP
rs1196160452 1212 dbSNP
rs377301238 1213 dbSNP
rs1027331447 1217 dbSNP
rs887965055 1218 dbSNP
rs985359903 1221 dbSNP
rs1004965354 1222 dbSNP
rs1015135344 1231 dbSNP
rs907649956 1238 dbSNP
rs1335467551 1250 dbSNP
rs1387360046 1257 dbSNP
rs780630185 1261 dbSNP
rs1400452866 1264 dbSNP
rs1455192248 1264 dbSNP
rs1176377974 1279 dbSNP
rs749983458 1288 dbSNP
rs972088111 1292 dbSNP
rs1322072423 1296 dbSNP
rs1178043384 1306 dbSNP
rs1003109540 1339 dbSNP
rs1231963991 1342 dbSNP
rs1362254195 1344 dbSNP
rs916624445 1345 dbSNP
rs958707390 1348 dbSNP
rs990254761 1349 dbSNP
rs1299696136 1354 dbSNP
rs73256849 1364 dbSNP
rs377525117 1365 dbSNP
rs1241080693 1366 dbSNP
rs878889492 1373 dbSNP
rs1202770233 1381 dbSNP
rs1324264987 1384 dbSNP
rs917607773 1389 dbSNP
rs947672729 1397 dbSNP
rs527650292 1399 dbSNP
rs1280384870 1404 dbSNP
rs776105297 1407 dbSNP
rs1044995125 1411 dbSNP
rs11556259 1421 dbSNP
rs1327079546 1422 dbSNP
rs544704997 1432 dbSNP
rs1210683266 1443 dbSNP
rs903728553 1445 dbSNP
rs1453824425 1453 dbSNP
rs1409036294 1461 dbSNP
rs553749650 1466 dbSNP
rs1398471708 1468 dbSNP
rs977954909 1472 dbSNP
rs1052691909 1484 dbSNP
rs923796463 1485 dbSNP
rs944643897 1486 dbSNP
rs879607866 1487 dbSNP
rs1018963753 1488 dbSNP
rs1182827999 1488 dbSNP
rs1244907990 1490 dbSNP
rs1359988860 1491 dbSNP
rs1040277747 1496 dbSNP
rs1446533928 1497 dbSNP
rs1285097903 1500 dbSNP
rs1225522013 1510 dbSNP
rs1357635071 1511 dbSNP
rs1314631650 1516 dbSNP
rs996548142 1519 dbSNP
rs1287659453 1522 dbSNP
rs1385372310 1522 dbSNP
rs1029251394 1527 dbSNP
rs1199976959 1532 dbSNP
rs1318473036 1533 dbSNP
rs1411167861 1534 dbSNP
rs921608144 1545 dbSNP
rs931642825 1548 dbSNP
rs1363334793 1550 dbSNP
rs1048797493 1552 dbSNP
rs887492189 1564 dbSNP
rs1242585312 1570 dbSNP
rs1004579363 1571 dbSNP
rs1036526773 1580 dbSNP
rs1345387518 1581 dbSNP
rs1184529800 1582 dbSNP
rs1475072565 1583 dbSNP
rs1242621680 1585 dbSNP
rs759112490 1589 dbSNP
rs72659900 1590 dbSNP
rs1448953070 1591 dbSNP
rs1003551534 1593 dbSNP
rs1291342750 1594 dbSNP
rs756346185 1595 dbSNP
rs1034586283 1609 dbSNP
rs1214334458 1613 dbSNP
rs958963112 1618 dbSNP
rs991920893 1622 dbSNP
rs1329733393 1627 dbSNP
rs1272364354 1628 dbSNP
rs1011549859 1635 dbSNP
rs947748640 1636 dbSNP
rs774886376 1641 dbSNP
rs1021628798 1671 dbSNP
rs1393412499 1676 dbSNP
rs967495448 1683 dbSNP
rs1302191492 1688 dbSNP
rs1405935043 1692 dbSNP
rs980844468 1695 dbSNP
rs1351207995 1697 dbSNP
rs1168074828 1700 dbSNP
rs542320288 1711 dbSNP
rs1288206023 1716 dbSNP
rs1409084661 1720 dbSNP
rs777141956 1725 dbSNP
rs1195731133 1731 dbSNP
rs1479523102 1734 dbSNP
rs977486301 1737 dbSNP
rs947934883 1738 dbSNP
rs925259146 1741 dbSNP
rs1230259095 1748 dbSNP
rs560605698 1752 dbSNP
rs1249769783 1758 dbSNP
rs762401199 1760 dbSNP
rs936572802 1765 dbSNP
rs1275780783 1769 dbSNP
rs1052299538 1772 dbSNP
rs892320764 1778 dbSNP
rs1222983965 1784 dbSNP
rs1369288786 1790 dbSNP
rs564231764 1790 dbSNP
rs77217544 1795 dbSNP
rs1441279220 1798 dbSNP
rs767729162 1800 dbSNP
rs901898891 1814 dbSNP
rs996223987 1817 dbSNP
rs185127909 1821 dbSNP
rs931654998 1827 dbSNP
rs1434977800 1828 dbSNP
rs77594100 1831 dbSNP
rs532414619 1834 dbSNP
rs1481187543 1842 dbSNP
rs1234992617 1847 dbSNP
rs1202112010 1849 dbSNP
rs547346997 1853 dbSNP
rs940467165 1855 dbSNP
rs1264224989 1859 dbSNP
rs1162174905 1870 dbSNP
rs1223663346 1871 dbSNP
rs1369847162 1878 dbSNP
rs560550722 1883 dbSNP
rs1304473570 1887 dbSNP
rs962212885 1888 dbSNP
rs760754385 1892 dbSNP
rs992287931 1910 dbSNP
rs1450107946 1911 dbSNP
rs1405349596 1914 dbSNP
rs1337298962 1921 dbSNP
rs1467692747 1937 dbSNP
rs907384963 1942 dbSNP
rs1024768465 1943 dbSNP
rs779426033 1950 dbSNP
rs980492612 1957 dbSNP
rs753964438 1958 dbSNP
rs1056458137 1959 dbSNP
rs894762226 1964 dbSNP
rs1202676553 1966 dbSNP
rs549322580 1974 dbSNP
rs1011833523 1978 dbSNP
rs549713043 1981 dbSNP
rs143258120 1982 dbSNP
rs1412276676 1985 dbSNP
rs1298805355 1997 dbSNP
rs998952291 1998 dbSNP
rs1310997677 2006 dbSNP
rs1243575717 2007 dbSNP
rs549545650 2013 dbSNP
rs1226695609 2020 dbSNP
rs567752564 2023 dbSNP
rs1315693170 2036 dbSNP
rs578217978 2037 dbSNP
rs1360479032 2046 dbSNP
rs966274646 2052 dbSNP
rs1273712405 2053 dbSNP
rs1339961570 2054 dbSNP
rs1362762402 2057 dbSNP
rs936327496 2060 dbSNP
rs1206625455 2065 dbSNP
rs1386214099 2066 dbSNP
rs1189997343 2067 dbSNP
rs975904678 2075 dbSNP
rs1029233653 2078 dbSNP
rs1488325607 2084 dbSNP
rs569793844 2086 dbSNP
rs752528472 2092 dbSNP
rs1257782112 2101 dbSNP
rs758391700 2116 dbSNP
rs1265834765 2126 dbSNP
rs932039216 2141 dbSNP
rs908897320 2151 dbSNP
rs566780343 2153 dbSNP
rs748343204 2153 dbSNP
rs1168326407 2154 dbSNP
rs1006187215 2158 dbSNP
rs1301564237 2162 dbSNP
rs1432162121 2163 dbSNP
rs116982627 2166 dbSNP
rs898076184 2168 dbSNP
rs972228748 2170 dbSNP
rs928372439 2176 dbSNP
rs1373070417 2177 dbSNP
rs938422462 2184 dbSNP
rs757773622 2187 dbSNP
rs1194490842 2194 dbSNP
rs1477885483 2202 dbSNP
rs571718552 2203 dbSNP
rs1013796459 2205 dbSNP
rs1025135722 2207 dbSNP
rs1290063477 2221 dbSNP
rs879169437 2225 dbSNP
rs1445864409 2226 dbSNP
rs770564240 2231 dbSNP
rs947648156 2240 dbSNP
rs370682068 2245 dbSNP
rs1304704794 2249 dbSNP
rs539332660 2253 dbSNP
rs969189613 2259 dbSNP
rs1043300408 2260 dbSNP
rs1281475344 2262 dbSNP
rs879026945 2273 dbSNP
rs554126475 2275 dbSNP
rs1002380884 2281 dbSNP
rs780861154 2287 dbSNP
rs1032065139 2299 dbSNP
rs1325760462 2300 dbSNP
rs998816549 2301 dbSNP
rs1020124881 2302 dbSNP
rs957952467 2306 dbSNP
rs1046341393 2312 dbSNP
rs1296597755 2313 dbSNP
rs901289570 2317 dbSNP
rs1467665833 2319 dbSNP
rs148892084 2322 dbSNP
rs987729661 2322 dbSNP
rs1246982634 2327 dbSNP
rs965250667 2330 dbSNP
rs997335467 2333 dbSNP
rs1249589180 2343 dbSNP
rs190466520 2344 dbSNP
rs1028847476 2354 dbSNP
rs953200655 2355 dbSNP
rs1198984300 2357 dbSNP
rs984692530 2359 dbSNP
rs745357081 2361 dbSNP
rs1264510320 2364 dbSNP
rs1345783201 2365 dbSNP
rs1276874174 2366 dbSNP
rs1335348444 2369 dbSNP
rs961696120 2372 dbSNP
rs971793071 2374 dbSNP
rs928289658 2381 dbSNP
rs932471008 2382 dbSNP
rs938471009 2391 dbSNP
rs1336634349 2394 dbSNP
rs909259785 2394 dbSNP
rs1173775466 2409 dbSNP
rs1187611819 2409 dbSNP
rs1468297948 2412 dbSNP
rs1245831471 2422 dbSNP
rs769241288 2423 dbSNP
rs942048047 2441 dbSNP
rs1458918291 2450 dbSNP
rs1241256019 2451 dbSNP
rs1036355030 2456 dbSNP
rs991635275 2461 dbSNP
rs898108992 2472 dbSNP
rs1451667553 2477 dbSNP
rs1013827807 2489 dbSNP
rs916093752 2490 dbSNP
rs1310257654 2492 dbSNP
rs1242839552 2496 dbSNP
rs1381008392 2497 dbSNP
rs1187504580 2512 dbSNP
rs947512223 2519 dbSNP
rs1315014108 2539 dbSNP
rs1449436993 2543 dbSNP
rs1046660410 2561 dbSNP
rs1335634989 2566 dbSNP
rs1043329270 2568 dbSNP
rs1398451445 2570 dbSNP
rs903399282 2571 dbSNP
rs934900331 2572 dbSNP
rs1158854880 2575 dbSNP
rs1041090778 2578 dbSNP
rs901149528 2579 dbSNP
rs1318714926 2582 dbSNP
rs1182698999 2586 dbSNP
rs1367645103 2588 dbSNP
rs1002344211 2591 dbSNP
rs996969040 2609 dbSNP
rs1425903256 2610 dbSNP
rs1049778317 2611 dbSNP
rs1432584599 2641 dbSNP
rs888952839 2642 dbSNP
rs1287067838 2654 dbSNP
rs1270589467 2655 dbSNP
rs1005976671 2661 dbSNP
rs957811627 2667 dbSNP
rs1382052683 2684 dbSNP
rs1009223576 2685 dbSNP
rs1016043636 2691 dbSNP
rs961976413 2692 dbSNP
rs7464 2693 dbSNP
rs1298232609 2694 dbSNP
rs762156891 2697 dbSNP
rs554286498 2702 dbSNP
rs1323539059 2703 dbSNP
rs1207582151 2712 dbSNP
rs1363267890 2713 dbSNP
rs1163813477 2717 dbSNP
rs1265806797 2718 dbSNP
rs1035392201 2727 dbSNP
rs779232262 2729 dbSNP
rs1184682884 2730 dbSNP
rs1264031661 2731 dbSNP
rs1475148588 2731 dbSNP
rs1489923813 2731 dbSNP
rs71671324 2731 dbSNP
rs1268362014 2732 dbSNP
rs959947115 2736 dbSNP
rs991271926 2741 dbSNP
rs1216930573 2742 dbSNP
rs1271555849 2748 dbSNP
rs1246551943 2754 dbSNP
rs371487403 2755 dbSNP
rs915622638 2765 dbSNP
rs968880895 2771 dbSNP
rs1278295183 2774 dbSNP
rs1477325383 2783 dbSNP
rs1202145768 2789 dbSNP
rs575718163 2797 dbSNP
rs182288658 2798 dbSNP
rs978956716 2807 dbSNP
rs1430631998 2818 dbSNP
rs1472275306 2822 dbSNP
rs924771019 2826 dbSNP
rs954015033 2838 dbSNP
rs1436992625 2840 dbSNP
rs772651273 2841 dbSNP
rs1157070748 2853 dbSNP
rs1391062624 2859 dbSNP
rs983968435 2860 dbSNP
rs1041680103 2864 dbSNP
rs1424177802 2868 dbSNP
rs909322714 2874 dbSNP
rs534587370 2875 dbSNP
rs1349153790 2877 dbSNP
rs1434032991 2879 dbSNP
rs773439580 2880 dbSNP
rs576928206 2882 dbSNP
rs1346106754 2883 dbSNP
rs1227213153 2884 dbSNP
rs1285970324 2885 dbSNP
rs1036387728 2890 dbSNP
rs148059219 2894 dbSNP
rs559383979 2895 dbSNP
rs1204196490 2900 dbSNP
rs1458611556 2904 dbSNP
rs184477248 2906 dbSNP
rs1450179573 2907 dbSNP
rs1320766554 2911 dbSNP
rs1300213696 2913 dbSNP
rs1047096702 2914 dbSNP
rs188106102 2918 dbSNP
rs1296250289 2920 dbSNP
rs905406970 2923 dbSNP
rs1005592396 2933 dbSNP
rs1333263931 2939 dbSNP
rs1270174524 2942 dbSNP
rs1468337670 2949 dbSNP
rs1053953170 2950 dbSNP
rs557924177 2955 dbSNP
rs897642115 2957 dbSNP
rs1009287374 2958 dbSNP
rs1180073812 2964 dbSNP
rs561395089 2970 dbSNP
rs1178484913 2971 dbSNP
rs1365665047 2972 dbSNP
rs531862158 2979 dbSNP
rs993443156 2984 dbSNP
rs900853847 2994 dbSNP
rs1411914575 2995 dbSNP
rs1491158645 2996 dbSNP
rs1491579271 2997 dbSNP
rs997767681 3000 dbSNP
rs1210132874 3007 dbSNP
rs1035992015 3012 dbSNP
rs141788479 3016 dbSNP
rs11556260 3019 dbSNP
rs1022627960 3021 dbSNP
rs538807387 3023 dbSNP
rs1409199415 3034 dbSNP
rs1311135470 3052 dbSNP
rs1450390505 3058 dbSNP
rs1401340154 3064 dbSNP
rs1305639360 3073 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 253943.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aacaggugaagaaGGACGGGAc 5'
                       :||||||| 
Target 5' -----------caUCUGCCCUu 3'
 		1 - 11
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000539294.1 | 3UTR | CAUCUGCCCUUAUACUCUUCACCAAACACACUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066957 ATXN7L3B ataxin 7 like 3B 2 8
MIRT119284 NABP1 nucleic acid binding protein 1 2 6
MIRT128915 KMT2A lysine methyltransferase 2A 2 2
MIRT150116 MIDN midnolin 2 2
MIRT173040 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT253117 BCL2L12 BCL2 like 12 2 2
MIRT256997 RGMB repulsive guidance molecule family member b 2 2
MIRT259746 SNX12 sorting nexin 12 2 2
MIRT267278 TMEM109 transmembrane protein 109 2 2
MIRT441934 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT443625 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT445757 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT447835 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT451230 ZNF444 zinc finger protein 444 2 2
MIRT451966 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453127 HOXC4 homeobox C4 2 2
MIRT454604 RPL13A ribosomal protein L13a 2 2
MIRT455176 SUV39H1 suppressor of variegation 3-9 homolog 1 2 2
MIRT455547 GJB1 gap junction protein beta 1 2 2
MIRT458197 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT458356 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458923 DNM2 dynamin 2 2 2
MIRT461013 SYT7 synaptotagmin 7 2 2
MIRT461643 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461997 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462367 BCL7B BCL tumor suppressor 7B 2 2
MIRT464915 TXNIP thioredoxin interacting protein 2 2
MIRT466311 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466591 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467045 SRSF1 serine and arginine rich splicing factor 1 2 2
MIRT468750 SDC2 syndecan 2 2 2
MIRT468943 RPS24 ribosomal protein S24 2 2
MIRT469474 REEP5 receptor accessory protein 5 2 2
MIRT469913 PTRF caveolae associated protein 1 2 2
MIRT473325 MEX3A mex-3 RNA binding family member A 2 2
MIRT473643 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474064 LMNB2 lamin B2 2 2
MIRT474357 KMT2D lysine methyltransferase 2D 2 2
MIRT475394 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476335 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT478651 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479585 CDC42SE1 CDC42 small effector 1 2 2
MIRT479943 CBX5 chromobox 5 2 2
MIRT482001 AMOTL2 angiomotin like 2 2 2
MIRT482043 AMER1 APC membrane recruitment protein 1 2 2
MIRT483070 EXT2 exostosin glycosyltransferase 2 2 6
MIRT484323 KCNH1 potassium voltage-gated channel subfamily H member 1 2 4
MIRT487528 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT489636 ALS2CL ALS2 C-terminal like 2 2
MIRT490693 SSTR1 somatostatin receptor 1 2 2
MIRT490871 UPK2 uroplakin 2 2 2
MIRT492582 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492945 NEUROD2 neuronal differentiation 2 2 2
MIRT498675 SOD2 superoxide dismutase 2 2 4
MIRT499349 RAB25 RAB25, member RAS oncogene family 2 2
MIRT502338 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT502976 CCNL1 cyclin L1 2 8
MIRT503706 NUP62 nucleoporin 62 2 2
MIRT505567 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT507808 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT513242 FBXO41 F-box protein 41 2 6
MIRT513586 EVX1 even-skipped homeobox 1 2 2
MIRT525036 FRK fyn related Src family tyrosine kinase 2 2
MIRT531035 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT531939 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT534912 PUM2 pumilio RNA binding family member 2 2 2
MIRT535717 N4BP1 NEDD4 binding protein 1 2 2
MIRT540498 ZMAT4 zinc finger matrin-type 4 2 4
MIRT541465 AURKA aurora kinase A 2 2
MIRT554328 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT561572 SLC6A9 solute carrier family 6 member 9 2 2
MIRT564715 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT576176 Hmox1 heme oxygenase 1 2 2
MIRT629712 XKR4 XK related 4 2 2
MIRT636182 THBD thrombomodulin 2 2
MIRT646315 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT649174 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT666945 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT684057 FOLR1 folate receptor 1 2 2
MIRT687585 MAU2 MAU2 sister chromatid cohesion factor 2 2
MIRT689953 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT704071 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT704327 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT705406 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT710488 CDH5 cadherin 5 2 2
MIRT718241 LCE1A late cornified envelope 1A 2 2
MIRT723182 CDCA4 cell division cycle associated 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4436b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4436b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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