miRTarBase - #MIRT175430


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pre-miRNA Information
pre-miRNA hsa-mir-4477a   
Genomic Coordinates chr9: 41233755 - 41233835
Description Homo sapiens miR-4477a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4477a
Sequence 48| CUAUUAAGGACAUUUGUGAUUC |69
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1281813060 1 dbSNP
rs1352899679 1 dbSNP
rs1283566158 2 dbSNP
rs1236244724 4 dbSNP
rs75019967 4 dbSNP
rs1348124293 5 dbSNP
rs34026740 8 dbSNP
rs1288237115 9 dbSNP
rs71262206 10 dbSNP
rs1355759977 11 dbSNP
rs1300249508 16 dbSNP
rs1328879592 18 dbSNP
rs139133717 20 dbSNP
Putative Targets

Gene Information
Gene Symbol ACSL4   
Synonyms ACS4, FACL4, LACS4, MRX63, MRX68
Description acyl-CoA synthetase long chain family member 4
Transcript NM_004458   
Other Transcripts NM_022977   
Expression
Putative miRNA Targets on ACSL4
3'UTR of ACSL4
(miRNA target sites are highlighted)		 
>ACSL4|NM_004458|3'UTR
   1 AATGTTGTTGTCTTATTGACAGTTGTGCAGGAGGTAGCCTGGTGGTTTTCAACCTCTAGAATTTTAAGCCTTTGTTGAAC
  81 TGTTAGAATGTAAGGTATATCATTCTAAAGATAGAGTAAAAAGAAAACAAAACCAAAAGTTATTAAAATTGTTGTCCGGT
 161 TTACTTTAACTTAGTTTTGCATAGTTCTAGTGCAGCTGAAATTGAAAAGTTATTTCCCTTTAGCTGTGTTATTATAGAGC
 241 AGAAATTCTGTTTTTAAAAATTAGCCTAAGATATACTTGTTTTTGTAAAGAAAAATATTTAATGTTGAACAAAATAAATT
 321 GGAGTTGGAGTAGAATGTAGTTTGAGGAAATTTGCAGCTTCCAATGCCTCTTGTCTTCCTATTTCAGAAGTTTAAATATT
 401 AAGCATGACAGAAAATATGTATTAACACTACTCAAAGCAAAAGTGCTGCAGGGCTTTAAAATTCTCTTCCAACCATTTAT
 481 CTTGAAGGAAAAATTCAATAGTAATATAATACACAAAATCAAATAATACCTTAGAAGGTATTAAGATTATAATTGTTGCA
 561 TAGGTTAGATATAGAGTCATTGTAATGTTGTGAATAATTACAGTGCCTAAAATAAGAATAGAACAACATATACAACACCA
 641 AAAAATATCTAGTAATATATTTAAAGGGAAATTGAGCTGCTTTTTTTGAAACTTTGAGATCTAAAAATAACTGTAATTAT
 721 TTGAATGACTAAGAGGAAAGTACATTTTTTGAAATGCTGAAAATTGCCTTTCTGTGTTTATTCAAACTGAAAAGCTGAGA
 801 CCAAGAGCAAGGAAGGTAAAAAGTTAACAGGCAAACATTTTCTCTTAGAAAAGGTGATAAAATCATAAGTATTTGGAATT
 881 AGAACCCTTGCACAGCACTGAACCTGGGAAAGAGATTTAAACTCTGAATTTATCTTTGATAACAGGGATTGATTTTAAAA
 961 TGTACATGTATTAAATTACATTTGTAATTTAAGGTCTGTTTGCTGTTGCTGATTTTATTCTTGATCAGTAGTTTGCATTT
1041 CAGAAAGCCTTTCATTTTGCTTTAATTTTAGCAAAGCGGGTTATAATGAATGACTTCCCCAATATCTTGCTTGAACTTAC
1121 AGGTGATTAACTTGGATGAGTTTTGGGAAGTTAAAGGGAAGAAAACACTGTTATCATTTTTTCCTGTTTGGGAAGAGCTT
1201 AGAAACTGGAAATACTAGATTTGGGAGAAGGGCAGAGTTACTTGATAAGGGACTGATGTTTGTGCAGTAACTTGGGAGTG
1281 TGGTTTCTTTTTGAATCTTTAATTAAAACCTGGGATTATATATCCCTGATAAATATTCACACTTGAACCATAGTTACTGT
1361 AAAATGCAAAAAATCTTAATACTGTTATTCTTTGCACTTTTTCTTAATCATTTTTTATATATATGCATATATATATGTGT
1441 GTGTGTGTGTTGCTTATGTTGTTTTGTACAGATGTGGGCCACCATTGCAACAAAATACATTCTTTTTGCTCTAAAATATT
1521 TATGAAGAAAATACTTAAATGTTATGTATATGGTGGTAATAAGGGAAAAATCAAGTATTATAAACAAGAATGAAGGTTTT
1601 TGTAAAGATTTCTGTTCAGCGTTTTGCAAGGTAAAATTTTAGGCAAGTTTTCCCTGAAGTTATGTGTATGTGAGTATTCT
1681 CATTCTTCCCAACTTGCCTTTGAAGAGTGAAATACCATTATTATCAAGTAGACTACTGTTCAGCTTTTATTCCTGCCCTG
1761 CTGTTTATCCCTTAAGAATGAGTTTCTTAGACTTTTCCAATATGTGATTTTTTTTCCCATTTAGAATGGTGATTTTAAAT
1841 GTGTGAGTGCATGTACTATCTTATCTCAGATATTTGCACCCCCAATCTGCCCCCAACTCCCAAAAGCTAGAACACTGCCA
1921 ACTGATCTGTTATAGGTCCTTTAGAAACACATAATTAACACTTAAGGTTGGGTGCTGCTAATTCTTTGCAAAAATCCAAA
2001 TATTGTTAAGGGACCAGGGAGATGCCACTACCCCTTGATTTTCCATCTAAAAATATACATGTTTATGTAAACAAATCTTT
2081 CCATATCCATAGTGACTTTTCAAGTATTTAAGCCTAAAGATTTTGATCTCACATTTTTATACCTGTTTAAATTGCTCACA
2161 GTTATTACATACACATCAGCCATCAACTAAAGTTGTACTTTAAAAATTTACTACAATATGTACATTTCTAAGTCAAACAC
2241 TTGTGACTTTTGCTTTAATTCCATGAATGTTCCTGCCTCCTTGATATTTGTATTTATTCTTTTTTTCTCTAGAGTAGAGG
2321 TATAATTGTGTGATATTTCAGAAATACAGATAAATGATTCAAAAAGTCACAGTTAAGGAGAATCATGTTTCTTTGATCAT
2401 GAATAACTGATTAGTAAGTCTTGCCTATATTTTCCTGATAGCATATGACAAATGTTTCTAAGGTAACAAGATGAGAACAG
2481 ATAAAGATTGTGTGGTGTTTTGGATTTGGAGAGAAATATTTTAATTTTTAAATGCAGTTACAAATTATAATGTATTCATA
2561 TTTGTACTTTCTGTTAAAATGCATGATTGCAGAATTGTTTAGATTTTGTGTTTATTCTTGATGAAAAGCTTTGTTTGTTC
2641 TTGTTTTTAAGTTTGCACTCAAATCTTAAGAAATAAATCCACCCATGTTATCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUAGUGUUUACAGGAAUUAUc 5'
            | ::||||   :||||||| 
Target 5' aaAATGCAAAAAATCTTAATAc 3'
 1361 - 1382 156.00 -5.80
2 
miRNA  3' cuuaGUGUUUAC--------AGGAAUUAUc 5'
              ||::||||        |||||:||| 
Target 5' attcCATGAATGTTCCTGCCTCCTTGATAt 3'
 2258 - 2287 144.00 -9.40
3 
miRNA  3' cuuAGUGUUUACAGGAAUUAuc 5'
             |::||  | |:||||||  
Target 5' tctTTGCACTTTTTCTTAATca 3'
 1389 - 1410 139.00 -5.90
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1290433423 2 dbSNP
rs760480845 10 dbSNP
rs1222642459 12 dbSNP
rs1166768947 13 dbSNP
rs773057024 14 dbSNP
rs756342527 18 dbSNP
rs764281998 21 dbSNP
rs763217379 22 dbSNP
rs150760891 27 dbSNP
rs769828137 28 dbSNP
rs765895091 30 dbSNP
rs777069871 35 dbSNP
rs184672678 37 dbSNP
rs1251302994 44 dbSNP
rs973692121 48 dbSNP
rs1056037005 52 dbSNP
rs1802109 54 dbSNP
rs1473144223 72 dbSNP
rs1199118282 88 dbSNP
rs1376228774 89 dbSNP
rs1033848425 95 dbSNP
rs1408634677 96 dbSNP
rs1479294918 99 dbSNP
rs765006032 112 dbSNP
rs1173617407 114 dbSNP
rs936026399 122 dbSNP
rs1186790085 126 dbSNP
rs1427900906 132 dbSNP
rs1310133268 134 dbSNP
rs1371375507 139 dbSNP
rs1477380070 157 dbSNP
rs10126612 158 dbSNP
rs1332537551 159 dbSNP
rs925904776 168 dbSNP
rs977510367 175 dbSNP
rs1195349618 179 dbSNP
rs1229929465 181 dbSNP
rs906608123 194 dbSNP
rs1274964997 208 dbSNP
rs1490089737 209 dbSNP
rs776499674 209 dbSNP
rs1468868437 231 dbSNP
rs763872669 248 dbSNP
rs1219720825 259 dbSNP
rs1265729267 267 dbSNP
rs1025093017 269 dbSNP
rs946083809 273 dbSNP
rs192073376 274 dbSNP
rs770153222 280 dbSNP
rs189248428 285 dbSNP
rs935936652 296 dbSNP
rs1309081196 297 dbSNP
rs1275352618 309 dbSNP
rs904489120 315 dbSNP
rs1038836909 330 dbSNP
rs1327939521 349 dbSNP
rs745454032 353 dbSNP
rs1170590404 354 dbSNP
rs1215407724 361 dbSNP
rs1366952444 364 dbSNP
rs1291944098 369 dbSNP
rs943236853 370 dbSNP
rs1387131193 381 dbSNP
rs1443681665 387 dbSNP
rs1372355461 388 dbSNP
rs1317602035 390 dbSNP
rs774434074 391 dbSNP
rs911625706 396 dbSNP
rs1230452335 400 dbSNP
rs987258549 409 dbSNP
rs147143931 419 dbSNP
rs1440437318 428 dbSNP
rs1242234158 440 dbSNP
rs780849019 448 dbSNP
rs183825301 472 dbSNP
rs1210789116 474 dbSNP
rs192123348 475 dbSNP
rs1356659059 492 dbSNP
rs1190988649 494 dbSNP
rs1248738043 498 dbSNP
rs774434989 511 dbSNP
rs1170659951 518 dbSNP
rs1444070676 523 dbSNP
rs918935977 528 dbSNP
rs1392657686 530 dbSNP
rs866309667 534 dbSNP
rs187600925 539 dbSNP
rs1458261933 542 dbSNP
rs1157800915 545 dbSNP
rs1454388994 561 dbSNP
rs1437210961 564 dbSNP
rs986065530 566 dbSNP
rs951719643 568 dbSNP
rs1393761080 569 dbSNP
rs1237462786 573 dbSNP
rs1314492938 576 dbSNP
rs963617941 577 dbSNP
rs1175462030 581 dbSNP
rs1481465414 582 dbSNP
rs1033964856 584 dbSNP
rs1327448306 598 dbSNP
rs1211186251 615 dbSNP
rs1205409505 620 dbSNP
rs980922380 641 dbSNP
rs1482988851 644 dbSNP
rs749545345 651 dbSNP
rs756913260 657 dbSNP
rs1424643189 672 dbSNP
rs751052819 677 dbSNP
rs778228465 682 dbSNP
rs897557419 695 dbSNP
rs1009663220 709 dbSNP
rs1458617113 715 dbSNP
rs1159872874 723 dbSNP
rs1236543652 729 dbSNP
rs1405240741 741 dbSNP
rs1464442096 755 dbSNP
rs1304112532 774 dbSNP
rs1379176987 774 dbSNP
rs773276770 788 dbSNP
rs756560797 791 dbSNP
rs1014866085 805 dbSNP
rs894636251 806 dbSNP
rs1306848104 808 dbSNP
rs1056453045 820 dbSNP
rs1230588837 823 dbSNP
rs936202794 829 dbSNP
rs748630454 836 dbSNP
rs781692510 849 dbSNP
rs892423673 862 dbSNP
rs904536389 865 dbSNP
rs1299112518 869 dbSNP
rs1257834404 871 dbSNP
rs1032341859 876 dbSNP
rs1000856559 885 dbSNP
rs1483613783 886 dbSNP
rs758344125 892 dbSNP
rs1204796248 895 dbSNP
rs1249857055 905 dbSNP
rs1447832964 908 dbSNP
rs373694162 943 dbSNP
rs757898990 965 dbSNP
rs182109695 970 dbSNP
rs943184328 975 dbSNP
rs890302342 980 dbSNP
rs1431374615 986 dbSNP
rs1178073102 995 dbSNP
rs1359293029 1027 dbSNP
rs1051913848 1053 dbSNP
rs1379179842 1063 dbSNP
rs1063544 1066 dbSNP
rs1371996118 1070 dbSNP
rs1410001472 1070 dbSNP
rs1431448992 1077 dbSNP
rs1367257396 1078 dbSNP
rs1217988132 1092 dbSNP
rs946010249 1099 dbSNP
rs922705545 1102 dbSNP
rs1227736514 1109 dbSNP
rs929071495 1126 dbSNP
rs1484178079 1131 dbSNP
rs111616134 1144 dbSNP
rs1420815187 1166 dbSNP
rs1245925926 1173 dbSNP
rs752697391 1174 dbSNP
rs375133823 1177 dbSNP
rs1192917519 1178 dbSNP
rs1425745411 1184 dbSNP
rs1448401334 1216 dbSNP
rs1166194722 1217 dbSNP
rs190157038 1234 dbSNP
rs185398001 1246 dbSNP
rs1255639220 1270 dbSNP
rs1213315114 1275 dbSNP
rs1349736652 1276 dbSNP
rs910348971 1280 dbSNP
rs754851853 1292 dbSNP
rs1295855988 1293 dbSNP
rs1486015255 1320 dbSNP
rs370638294 1349 dbSNP
rs181617170 1351 dbSNP
rs750624131 1358 dbSNP
rs55955620 1359 dbSNP
rs1295502602 1365 dbSNP
rs1434963653 1365 dbSNP
rs1344337124 1367 dbSNP
rs1260222939 1381 dbSNP
rs1229489348 1388 dbSNP
rs986020871 1395 dbSNP
rs1319745518 1397 dbSNP
rs1237443033 1406 dbSNP
rs377139823 1415 dbSNP
rs1186520335 1417 dbSNP
rs1464409620 1417 dbSNP
rs1027297065 1425 dbSNP
rs1449528109 1425 dbSNP
rs1233024925 1427 dbSNP
rs1354011007 1435 dbSNP
rs1167394918 1437 dbSNP
rs1294693817 1437 dbSNP
rs1406693350 1437 dbSNP
rs1415053175 1439 dbSNP
rs752654601 1440 dbSNP
rs1319116773 1441 dbSNP
rs1283871282 1451 dbSNP
rs1367525379 1451 dbSNP
rs774382151 1451 dbSNP
rs1286630733 1456 dbSNP
rs372686883 1468 dbSNP
rs1230197098 1469 dbSNP
rs1376567243 1471 dbSNP
rs759628048 1474 dbSNP
rs1328153157 1475 dbSNP
rs1206805324 1496 dbSNP
rs1269914243 1498 dbSNP
rs1464998481 1500 dbSNP
rs1345712420 1522 dbSNP
rs1186257641 1531 dbSNP
rs1164053565 1536 dbSNP
rs774490336 1547 dbSNP
rs771016316 1567 dbSNP
rs1419794001 1577 dbSNP
rs1182025915 1585 dbSNP
rs1024509395 1587 dbSNP
rs1419105845 1590 dbSNP
rs1013965456 1591 dbSNP
rs1190246417 1596 dbSNP
rs894643241 1602 dbSNP
rs763256146 1604 dbSNP
rs1203460790 1608 dbSNP
rs767757067 1620 dbSNP
rs1167735778 1622 dbSNP
rs1333626986 1624 dbSNP
rs1034493609 1629 dbSNP
rs1284984096 1636 dbSNP
rs1261806090 1644 dbSNP
rs1226326930 1652 dbSNP
rs761979255 1654 dbSNP
rs1213643342 1655 dbSNP
rs774483110 1657 dbSNP
rs1333098267 1668 dbSNP
rs1199743412 1692 dbSNP
rs1275451130 1713 dbSNP
rs1000466811 1714 dbSNP
rs1233462387 1716 dbSNP
rs191555789 1725 dbSNP
rs1250576318 1728 dbSNP
rs1472496062 1732 dbSNP
rs1041977772 1733 dbSNP
rs1414595122 1743 dbSNP
rs1470799596 1755 dbSNP
rs1172442213 1786 dbSNP
rs369019927 1791 dbSNP
rs1416234134 1792 dbSNP
rs11552088 1795 dbSNP
rs1313774489 1798 dbSNP
rs1370214318 1800 dbSNP
rs1408193779 1815 dbSNP
rs1309631021 1816 dbSNP
rs1336068316 1816 dbSNP
rs1232517093 1818 dbSNP
rs1273002825 1819 dbSNP
rs1010274204 1841 dbSNP
rs1219281484 1847 dbSNP
rs55942537 1871 dbSNP
rs901168653 1877 dbSNP
rs1293084867 1882 dbSNP
rs1383390024 1896 dbSNP
rs748579148 1933 dbSNP
rs1041531653 1949 dbSNP
rs764134683 1950 dbSNP
rs1254430230 1962 dbSNP
rs781654441 1988 dbSNP
rs1438734809 2027 dbSNP
rs1198858481 2038 dbSNP
rs1245451745 2040 dbSNP
rs942767611 2047 dbSNP
rs186824192 2049 dbSNP
rs745309859 2050 dbSNP
rs1459809871 2067 dbSNP
rs1396330440 2077 dbSNP
rs137881687 2081 dbSNP
rs1464967183 2083 dbSNP
rs1372687112 2087 dbSNP
rs756812791 2089 dbSNP
rs1296231432 2090 dbSNP
rs1339369647 2098 dbSNP
rs34685485 2102 dbSNP
rs1230229394 2118 dbSNP
rs1251522234 2119 dbSNP
rs775976627 2130 dbSNP
rs753510007 2139 dbSNP
rs868601242 2145 dbSNP
rs1209644922 2161 dbSNP
rs1265663702 2162 dbSNP
rs547199680 2169 dbSNP
rs755973416 2174 dbSNP
rs1193485175 2185 dbSNP
rs1467540199 2208 dbSNP
rs1190796627 2216 dbSNP
rs1373837900 2218 dbSNP
rs962053671 2220 dbSNP
rs770100180 2222 dbSNP
rs992999707 2245 dbSNP
rs752601369 2253 dbSNP
rs958457928 2263 dbSNP
rs767492755 2266 dbSNP
rs1000393082 2275 dbSNP
rs1242079682 2276 dbSNP
rs968863880 2299 dbSNP
rs1337395384 2307 dbSNP
rs1214933873 2311 dbSNP
rs1268020547 2312 dbSNP
rs1463639932 2320 dbSNP
rs1020586178 2328 dbSNP
rs1262468308 2339 dbSNP
rs1423464634 2345 dbSNP
rs759573098 2347 dbSNP
rs1307495841 2371 dbSNP
rs1370031603 2379 dbSNP
rs1475407942 2382 dbSNP
rs1302079327 2397 dbSNP
rs1438154311 2406 dbSNP
rs1373089279 2415 dbSNP
rs751542151 2443 dbSNP
rs901178949 2449 dbSNP
rs79265406 2458 dbSNP
rs1474647376 2472 dbSNP
rs1041023187 2478 dbSNP
rs1390583679 2479 dbSNP
rs1007405550 2488 dbSNP
rs1314426927 2497 dbSNP
rs889902470 2498 dbSNP
rs1234260120 2503 dbSNP
rs1288064610 2506 dbSNP
rs1463725965 2513 dbSNP
rs1327738392 2533 dbSNP
rs1218473469 2534 dbSNP
rs1048451107 2536 dbSNP
rs1390805808 2547 dbSNP
rs746212449 2552 dbSNP
rs766457257 2558 dbSNP
rs1485903250 2573 dbSNP
rs920426634 2583 dbSNP
rs1409409806 2598 dbSNP
rs1473541322 2600 dbSNP
rs1159733823 2608 dbSNP
rs1036245240 2609 dbSNP
rs1452733479 2627 dbSNP
rs1376645828 2640 dbSNP
rs1464079310 2655 dbSNP
rs1304277331 2668 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 2182.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714642
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000469796.2 | 3UTR | CAAAAAAUCUUAAUACUGUUAUUCUUUGCACUUUUUCUUAAUCAUUUUUUAUAUAUAUGCAUAUAUAUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000469796.2 | 3UTR | CAAAAAAUCUUAAUACUGUUAUUCUUUGCACUUUUUCUUAAUCAUUUUUUAUAUAUAUGCAUAUAUAUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
134 hsa-miR-4477a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055843 PLEKHA1 pleckstrin homology domain containing A1 2 10
MIRT061259 AMOTL1 angiomotin like 1 2 4
MIRT071895 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT076933 MLLT6 MLLT6, PHD finger containing 2 2
MIRT078652 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT083633 PRNP prion protein 2 2
MIRT091629 RPL15 ribosomal protein L15 2 4
MIRT107076 PPP6C protein phosphatase 6 catalytic subunit 2 2
MIRT111191 TRIM33 tripartite motif containing 33 2 2
MIRT114515 ARF6 ADP ribosylation factor 6 2 2
MIRT175250 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT175430 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178687 FAM102B family with sequence similarity 102 member B 2 2
MIRT189771 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT229450 RPL10 ribosomal protein L10 2 2
MIRT244899 PHF6 PHD finger protein 6 2 2
MIRT249189 AKIRIN1 akirin 1 2 8
MIRT261134 TRIM8 tripartite motif containing 8 2 2
MIRT275561 ZIC5 Zic family member 5 2 4
MIRT275652 ABHD13 abhydrolase domain containing 13 2 2
MIRT288082 UTP18 UTP18, small subunit processome component 2 2
MIRT303605 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT307924 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT316787 FOXC1 forkhead box C1 2 2
MIRT326910 SCML2 Scm polycomb group protein like 2 2 2
MIRT327713 SPIN4 spindlin family member 4 2 2
MIRT331632 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT342506 TMOD3 tropomodulin 3 2 4
MIRT354470 LRRC58 leucine rich repeat containing 58 2 2
MIRT378711 TRIM24 tripartite motif containing 24 2 2
MIRT407462 YDJC YdjC chitooligosaccharide deacetylase homolog 2 2
MIRT408226 SMAD5 SMAD family member 5 2 4
MIRT441824 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442783 CHD8 chromodomain helicase DNA binding protein 8 2 2
MIRT443184 NHS NHS actin remodeling regulator 2 4
MIRT447615 CUL3 cullin 3 2 2
MIRT450156 DSEL dermatan sulfate epimerase-like 2 2
MIRT454801 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT463050 ZNF644 zinc finger protein 644 2 2
MIRT467400 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT468174 SGMS1 sphingomyelin synthase 1 2 2
MIRT468949 RPS14 ribosomal protein S14 2 6
MIRT469835 R3HDM4 R3H domain containing 4 2 2
MIRT470724 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT470902 PLIN3 perilipin 3 2 2
MIRT472467 NAPG NSF attachment protein gamma 2 12
MIRT472602 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT492350 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493840 FOXN3 forkhead box N3 2 4
MIRT496318 DOCK9 dedicator of cytokinesis 9 2 2
MIRT500159 CLEC2D C-type lectin domain family 2 member D 2 8
MIRT500535 XPO4 exportin 4 2 4
MIRT503916 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT504003 SAT1 spermidine/spermine N1-acetyltransferase 1 2 4
MIRT505647 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT506574 MIER3 MIER family member 3 2 4
MIRT506945 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 4
MIRT508196 RPS19 ribosomal protein S19 2 6
MIRT511417 HSPA13 heat shock protein family A (Hsp70) member 13 2 4
MIRT512326 ACTB actin beta 2 4
MIRT515376 RPL7 ribosomal protein L7 2 2
MIRT520422 TUBG1 tubulin gamma 1 2 4
MIRT524844 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT526320 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526561 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT528027 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT529874 RBM43 RNA binding motif protein 43 2 2
MIRT530826 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT531334 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT532068 CCNB1 cyclin B1 2 4
MIRT532870 ZNF566 zinc finger protein 566 2 2
MIRT535580 NUP35 nucleoporin 35 2 2
MIRT537644 ERGIC2 ERGIC and golgi 2 2 4
MIRT537725 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT538894 BRI3BP BRI3 binding protein 2 2
MIRT538945 BMP2K BMP2 inducible kinase 2 2
MIRT540703 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT543210 TMEM117 transmembrane protein 117 2 3
MIRT543357 LYRM2 LYR motif containing 2 2 2
MIRT544905 CLSPN claspin 2 2
MIRT545532 ARF3 ADP ribosylation factor 3 2 2
MIRT546446 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT546882 PURB purine rich element binding protein B 2 4
MIRT547440 MED13 mediator complex subunit 13 2 2
MIRT548027 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548673 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 2
MIRT550435 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT551850 RPS3 ribosomal protein S3 2 2
MIRT556072 MRFAP1 Morf4 family associated protein 1 2 2
MIRT556554 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT557132 HOXA13 homeobox A13 2 2
MIRT557875 FEM1B fem-1 homolog B 2 4
MIRT558146 ELK4 ELK4, ETS transcription factor 2 2
MIRT558862 CD2AP CD2 associated protein 2 2
MIRT558884 CCNE1 cyclin E1 2 4
MIRT558907 CBX5 chromobox 5 2 2
MIRT559175 BRAP BRCA1 associated protein 2 2
MIRT560860 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561729 PPIF peptidylprolyl isomerase F 2 2
MIRT564024 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT564366 TRMT5 tRNA methyltransferase 5 2 2
MIRT564609 ZNF703 zinc finger protein 703 2 2
MIRT565494 AZF1 azoospermia factor 1 2 2
MIRT565577 SLC6A8 solute carrier family 6 member 8 2 2
MIRT566947 LEPROT leptin receptor overlapping transcript 2 2
MIRT567293 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT567308 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT568048 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT571807 PHF19 PHD finger protein 19 2 2
MIRT609234 RBM23 RNA binding motif protein 23 2 2
MIRT610328 SSX5 SSX family member 5 2 2
MIRT611428 UGT8 UDP glycosyltransferase 8 2 4
MIRT611709 SLFN13 schlafen family member 13 2 2
MIRT612069 CEP135 centrosomal protein 135 2 4
MIRT617676 JRKL JRK like 2 2
MIRT623684 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT635634 PRR15L proline rich 15 like 2 2
MIRT636422 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT637011 GPATCH11 G-patch domain containing 11 2 2
MIRT644150 C4orf3 chromosome 4 open reading frame 3 2 2
MIRT648562 MEMO1 mediator of cell motility 1 2 2
MIRT650752 WNT16 Wnt family member 16 2 2
MIRT651914 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT653556 SLC38A7 solute carrier family 38 member 7 2 2
MIRT692277 XRN2 5'-3' exoribonuclease 2 2 2
MIRT697650 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT703876 ERCC6 ERCC excision repair 6, chromatin remodeling factor 2 2
MIRT704615 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708562 BBOX1 gamma-butyrobetaine hydroxylase 1 2 2
MIRT709614 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT712955 SGCD sarcoglycan delta 2 2
MIRT713502 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT720239 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT724255 GLUD1 glutamate dehydrogenase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4477a Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4477a Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4477a Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)

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