miRTarBase - #MIRT175514


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pre-miRNA Information
pre-miRNA hsa-mir-4729   
Genomic Coordinates chr17: 59366083 - 59366154
Description Homo sapiens miR-4729 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4729
Sequence 10| UCAUUUAUCUGUUGGGAAGCUA |31
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN28205519 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1167550125 15 dbSNP
rs1022075979 18 dbSNP
rs967769645 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ZBTB33   
Synonyms ZNF-kaiso, ZNF348
Description zinc finger and BTB domain containing 33
Transcript NM_001184742   
Other Transcripts NM_006777   
Expression
Putative miRNA Targets on ZBTB33
3'UTR of ZBTB33
(miRNA target sites are highlighted)		 
>ZBTB33|NM_001184742|3'UTR
   1 ACTCCTTTGAAATACTAGAAAGTTTTGTTTTGGATGATGGGGCAGGGGTTTCAGAAGATCTGTAAAACAAATTAAGGTGC
  81 GAACAAGTTAATTTGATCTGCCACATTATCTGAAGGAAGTGTAGTGGGATTTTTGTTGATAATTTTTAGAAGCAAATTTT
 161 CCTGAAAGTTTTGAGTAGAGGTGAGACCCCCTCCCCAAGTATCTGTTTATATAGTTAGTTTTCAGCTCATTTAAAAGAGG
 241 CAAAAATTAAAAGCTTGGAGAGATAGTTTCCTGAATAGAATTTGAAGCAGTCTGAATGTTCTTTGAAAATAACTGGAGTT
 321 ATTAGCATACCCTAGTACATCTTACAGCTTTCCCCTTCCATGTTAGCACTTTACTGCTGAATTCTCAATTTTCTTAACAT
 401 TGAGACAATAAATGTGTGTTTTGTCTTGTATATGGCATAAAGAGTAAATAAGTTTTAGAGTTGTTCTGGAAAATGTCAGA
 481 ATAAGTCAGTACTTGGGTTGTGTAATCTGCTAGTCCAAGCGAACAGCAACCTCCTGCTACCCTCCCTCTATGAAAATAGC
 561 CATGCAGACAAGTCTCTCATCTGAAGAACAAATTAGATTTAGCTAATTAGAATTAATCCTGGCTTTCATTGCCATAGTCT
 641 GTAAAAGACTTTGGTGGCTAGACCACTTTATACCTTCGCAGTGTGGTCTCTGGGGGCAAAAAACTAATGAAAACAATCTC
 721 TGTAATGGCAGATAGGAGGAGATGAAAAGTTCTGTTGCATGGATTTTTAATTCTCTGGCTACCACATAGTAGAGAATGGA
 801 ATGAAGATTTCCTTTTGGCTTCTTAAGGTTAAAAATATTCCCATGAACATGAAAATTTTCAAATTTTGAATCTGAAAGCC
 881 ACCAAATGTATCTTTATGTATAAATCCTTGTAAATGATAGATTCCATGGGTGAGACTTTACATATTTTGGGTGGGAGGCT
 961 ACTGGCATATATTTTTAAATGTTCATATTGCGTAGAATCTCCACTAGGAAGTCTTTATTTGAAATAGTTGAATCAGTGAT
1041 CTAGTATTTTCCTTTCGGCAAGATTTGTTAGGTTTTTACCCCTTCTAAAATAAGTTTTATTCCATCTGCAAATTGCTGCA
1121 ATATTATAGTAATCAGAAACTACATAAGGAATGTTATATAGGCTTGTCAGTTCCCATTTTTCTTGACAACAATAAATACC
1201 ACTTTTAAAAATGACACATATTTAAACACTTAGAAAATAAAGTTAACACTTACTGAAGTGCTAGTACTAAACTGTGCTAG
1281 TACTAAAAGAAAACAGGTTGGAACATACATATAGCCTAGCATTTATAACAGAATTGTTGAACGTCTGTAAATGATTTTTT
1361 TTTTTTTTGCAAAGGAAAAAATTGATACTGGAAAAGATTGTTGTGCATAGTTATTAGTCATTTGTAACCTTGCTTAAGTA
1441 TTTCTTAGTCCAACATAGATATTTTCTTTCTCCTGACCATGTATTTTAAAATATAGTCTATTTCTTGACTTTGAACTTAA
1521 AGCTTTAATCATAATTTCTCATGTATACATCGTTCTTCTGATGGTAAGCTGGATTTGAAGGTAGTGGTTTCAGTGTTTCT
1601 TAAGTTGGTAGCTGAGGGTATCAGGCATCAGTTCATGCAATAATACAAGAAAAAAAATCCTTTGCTTGCCAAGAGGTAGA
1681 GTGATGTGCATTTATCTGTTTTCTGTTCTGTAAGTCTAGACCTTCAAACCATTTGTAAACTAACCCCTGGGAAATTTGAA
1761 ATTACCTGATAACTTAAGACTCTGTGATCTCTGGAATCACCATATGTTTCTTTTTTGTGTAGATATTAATAACATTACTC
1841 TTTGACTATAGTGTGCACTCTGAAATGTACTCAGTGAAAATTTGTTTTGAGTTTCATTAATGCTATTTCACCAGTTAGAC
1921 ATAATTACTTCTACCGATGTGAATGATACGGATGCCGGCAGAGCTTCCAGATCTTTCAGACTCAACTGCTAGGTCAATTA
2001 GTTTGTCATAATAAAACTTGGCAGATTCTACAAGTCTATTATGACAAACCAGGAACTAATTCTATAATGGAAAACTATCC
2081 ATTCTGAATAATAGGTATGTAATTATTTGCTGCTGCTGCTGTGCTCTGTAAATTCTGAATATGACATTTAAACTCTGTGC
2161 CTACTAAAGGTATCTTCTGGAGTTTTTGGGAGGAGAGAAACTGGAAAATTAAATTGTATTTTTGCCAGAAGACTCTTACT
2241 TGCATGTGTCTCAGGGTCTTCAGTTTTTCTATAAGTTTCCATATCCAAAGTTCAGAATTCATGTGAAATACTTCTTTGGG
2321 GCAAAAGTCCTTCATTCCTGGTATTTATTGGATTGGAAATCTGTAGCAAGATGCTGTTTAAAATTACCATATTGTTTTTT
2401 TATCTTATACTTAGCTCTCTGGCTATTGAACTTCCTTTTCTTGTTTGAAGTTAGCTTCAAATTTGCTCCTATGCTAAATT
2481 ACCTGTAAATATTCTGGATAGGAACTACTTGAAATAGTAATTTGTTAAAAGATATGACAAAATGAAAATGCTTAAACTAC
2561 AGAAATTTAAAAATGCCATAACAATCTTGCGAGACTAACTTTAAAATATACTTTAAATGATTATTATGATTTTGGTGGTA
2641 ACGATCCCCCACACACAACCACTATGAAGAAATAATGCCGCATTTTTCCCCCATTGTACCAAAAAGATAAAAAAATGGTA
2721 AACACTGATCAAGGTATTTTGTATTGTCAAGGCATGCATATTCTAAAGAATTAAATGCTAACTTAACAGCACTGGCTTTC
2801 TGGCTGGTCAACTATATGAAACCTTGTTCATTCCTCCGAGTACTGTAATGTTCACACTTGTACAATCTTCCCTGTCATGA
2881 CTTTAAGTTCTACTTTTCATTAACCATGGCCTGATATTAGTTCTTAGAGCTTCTTGTGGCAAAAATAAAATGATTTAATT
2961 CTAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aucGAAGGGUUG----UC---UAUUUACu 5'
             :|||::|||    ||   ||||||| 
Target 5' aatTTTCTTAACATTGAGACAATAAATGt 3'
 387 - 415 157.00 -9.30
2 
miRNA  3' aucGAAGGGUUGUCUAUUUAcu 5'
             |||  ||||| ||||||  
Target 5' tttCTTGACAACA-ATAAATac 3'
 1179 - 1199 146.00 -8.00
3 
miRNA  3' aucgAAGGGUUGUCUAUUUACu 5'
              |||: || |  |||||| 
Target 5' cataTTCTAAAGAATTAAATGc 3'
 2757 - 2778 130.00 -6.20
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs782263109 2 dbSNP
rs782218082 5 dbSNP
rs782337560 10 dbSNP
rs781927736 16 dbSNP
rs1434113200 20 dbSNP
rs782173779 26 dbSNP
rs782803950 38 dbSNP
rs782000872 39 dbSNP
rs782691586 45 dbSNP
rs1419953267 58 dbSNP
rs1175337468 81 dbSNP
rs781906430 82 dbSNP
rs1258054183 85 dbSNP
rs1210112347 87 dbSNP
rs374847229 90 dbSNP
rs1025109821 91 dbSNP
rs1287599559 93 dbSNP
rs782536589 101 dbSNP
rs970420105 104 dbSNP
rs1240381841 134 dbSNP
rs1004993482 141 dbSNP
rs1306720759 170 dbSNP
rs1389971375 178 dbSNP
rs139977503 181 dbSNP
rs1313978842 190 dbSNP
rs1414739027 210 dbSNP
rs1373689589 212 dbSNP
rs782244755 213 dbSNP
rs1300163356 217 dbSNP
rs1454502645 218 dbSNP
rs1363376585 219 dbSNP
rs961956166 224 dbSNP
rs974300245 227 dbSNP
rs782211281 234 dbSNP
rs1425288257 256 dbSNP
rs1418350985 260 dbSNP
rs782323742 265 dbSNP
rs1484679734 273 dbSNP
rs1264692042 284 dbSNP
rs1205275948 310 dbSNP
rs371662050 331 dbSNP
rs1485262195 335 dbSNP
rs1258522588 338 dbSNP
rs182404987 346 dbSNP
rs1323837867 383 dbSNP
rs781925693 400 dbSNP
rs1233182888 410 dbSNP
rs782172272 412 dbSNP
rs67998482 413 dbSNP
rs1382795622 421 dbSNP
rs1384379885 429 dbSNP
rs1287296370 430 dbSNP
rs1459679555 443 dbSNP
rs1164025878 445 dbSNP
rs1394918552 445 dbSNP
rs1474183297 456 dbSNP
rs187089793 467 dbSNP
rs1193827354 479 dbSNP
rs1427357731 486 dbSNP
rs573793410 493 dbSNP
rs1211230360 497 dbSNP
rs1468679892 507 dbSNP
rs782008746 510 dbSNP
rs1274180900 522 dbSNP
rs73607657 523 dbSNP
rs1333149942 531 dbSNP
rs1272387192 536 dbSNP
rs1228836798 545 dbSNP
rs1293587595 558 dbSNP
rs1388730577 572 dbSNP
rs1372089608 596 dbSNP
rs372539982 598 dbSNP
rs1459624820 604 dbSNP
rs1402221478 626 dbSNP
rs1168384941 629 dbSNP
rs1461455254 635 dbSNP
rs192233362 650 dbSNP
rs1200441242 667 dbSNP
rs1454441857 671 dbSNP
rs7882480 678 dbSNP
rs1191388780 698 dbSNP
rs1467389656 711 dbSNP
rs1275603926 717 dbSNP
rs1196866900 730 dbSNP
rs1339376356 730 dbSNP
rs782519453 734 dbSNP
rs373311722 755 dbSNP
rs1236502362 763 dbSNP
rs1371836397 779 dbSNP
rs1302891547 787 dbSNP
rs1439021919 788 dbSNP
rs1378794263 796 dbSNP
rs1329349587 798 dbSNP
rs1390733394 810 dbSNP
rs781975565 813 dbSNP
rs1394327810 824 dbSNP
rs1174247669 828 dbSNP
rs782085041 849 dbSNP
rs1434730208 863 dbSNP
rs782761167 871 dbSNP
rs1393992385 891 dbSNP
rs1171331249 905 dbSNP
rs1441219540 911 dbSNP
rs781829693 924 dbSNP
rs1183074099 940 dbSNP
rs1437616575 943 dbSNP
rs1248964085 945 dbSNP
rs1213670126 951 dbSNP
rs1348632209 953 dbSNP
rs1279754445 968 dbSNP
rs1232339655 988 dbSNP
rs782071210 990 dbSNP
rs58628009 992 dbSNP
rs1333777275 995 dbSNP
rs1314606814 997 dbSNP
rs57741634 1008 dbSNP
rs1415369455 1026 dbSNP
rs1374301625 1028 dbSNP
rs1310609136 1035 dbSNP
rs182982429 1036 dbSNP
rs1408179180 1042 dbSNP
rs1157650044 1051 dbSNP
rs1469903835 1058 dbSNP
rs1362454780 1074 dbSNP
rs1190657599 1081 dbSNP
rs1486312267 1083 dbSNP
rs1256880073 1087 dbSNP
rs1208904212 1101 dbSNP
rs1448815012 1109 dbSNP
rs188734277 1115 dbSNP
rs1204793480 1117 dbSNP
rs1348241509 1122 dbSNP
rs1294958633 1127 dbSNP
rs782807099 1128 dbSNP
rs1291371867 1160 dbSNP
rs1432216758 1169 dbSNP
rs11537755 1177 dbSNP
rs1317147011 1186 dbSNP
rs193208167 1189 dbSNP
rs1386880475 1196 dbSNP
rs1167623165 1207 dbSNP
rs782458296 1214 dbSNP
rs1417685530 1216 dbSNP
rs782529940 1218 dbSNP
rs1186435885 1223 dbSNP
rs1476402742 1233 dbSNP
rs1242821871 1234 dbSNP
rs184955675 1242 dbSNP
rs1445556526 1248 dbSNP
rs1274812189 1251 dbSNP
rs1214018366 1258 dbSNP
rs1333907290 1313 dbSNP
rs879990962 1322 dbSNP
rs1216289898 1330 dbSNP
rs1271142080 1330 dbSNP
rs1361999665 1346 dbSNP
rs1269128088 1348 dbSNP
rs1428198136 1351 dbSNP
rs1163239082 1355 dbSNP
rs1372807266 1355 dbSNP
rs1412182041 1355 dbSNP
rs782587377 1355 dbSNP
rs1420304718 1368 dbSNP
rs782280380 1369 dbSNP
rs1186074537 1370 dbSNP
rs1474470927 1371 dbSNP
rs1255059802 1376 dbSNP
rs5910810 1377 dbSNP
rs1250950614 1383 dbSNP
rs1206510866 1387 dbSNP
rs1308063801 1407 dbSNP
rs1271673770 1414 dbSNP
rs1212226648 1419 dbSNP
rs1349433142 1429 dbSNP
rs1303620983 1434 dbSNP
rs1439742140 1454 dbSNP
rs1370693053 1486 dbSNP
rs561168130 1492 dbSNP
rs188936790 1518 dbSNP
rs1292210710 1531 dbSNP
rs1444986746 1543 dbSNP
rs1355558548 1545 dbSNP
rs1170377506 1550 dbSNP
rs142166317 1552 dbSNP
rs1174465403 1553 dbSNP
rs781832263 1553 dbSNP
rs1454036123 1561 dbSNP
rs1264986563 1580 dbSNP
rs782163990 1592 dbSNP
rs1178796853 1626 dbSNP
rs1480838598 1627 dbSNP
rs1232171970 1639 dbSNP
rs1202380513 1640 dbSNP
rs373167622 1647 dbSNP
rs782237939 1647 dbSNP
rs1280467001 1650 dbSNP
rs1486341941 1650 dbSNP
rs1233097618 1651 dbSNP
rs1345382933 1658 dbSNP
rs1225776611 1660 dbSNP
rs782347618 1675 dbSNP
rs1374538609 1703 dbSNP
rs1298066875 1706 dbSNP
rs1408580396 1726 dbSNP
rs782457040 1727 dbSNP
rs1377329998 1736 dbSNP
rs1313622295 1745 dbSNP
rs782590085 1747 dbSNP
rs192250180 1750 dbSNP
rs782179006 1751 dbSNP
rs1419398733 1765 dbSNP
rs1407013838 1773 dbSNP
rs1179881753 1800 dbSNP
rs1476181929 1833 dbSNP
rs782176537 1834 dbSNP
rs1257602814 1835 dbSNP
rs1209450354 1841 dbSNP
rs1484413964 1856 dbSNP
rs1262074955 1860 dbSNP
rs1216106052 1873 dbSNP
rs1317865614 1875 dbSNP
rs1306799058 1881 dbSNP
rs782436081 1897 dbSNP
rs1227079152 1901 dbSNP
rs1357986196 1911 dbSNP
rs1294448053 1914 dbSNP
rs782014405 1916 dbSNP
rs782428185 1932 dbSNP
rs782671981 1936 dbSNP
rs868983808 1937 dbSNP
rs151207016 1940 dbSNP
rs1344359953 1945 dbSNP
rs1156770603 1948 dbSNP
rs1476069320 1948 dbSNP
rs1418418584 1950 dbSNP
rs1187166307 1952 dbSNP
rs184089476 1956 dbSNP
rs782273169 1957 dbSNP
rs782380253 1958 dbSNP
rs1186723113 1969 dbSNP
rs1485372920 1980 dbSNP
rs1267885618 1996 dbSNP
rs1207143894 2008 dbSNP
rs188822549 2019 dbSNP
rs781963460 2020 dbSNP
rs1274296294 2021 dbSNP
rs1233240886 2022 dbSNP
rs1338743085 2029 dbSNP
rs1297874468 2044 dbSNP
rs540993656 2046 dbSNP
rs1361454970 2047 dbSNP
rs1318805973 2050 dbSNP
rs1462779006 2052 dbSNP
rs1394985917 2053 dbSNP
rs1164091615 2057 dbSNP
rs1456375996 2074 dbSNP
rs1374282262 2078 dbSNP
rs1427412704 2095 dbSNP
rs781968682 2096 dbSNP
rs1195134438 2099 dbSNP
rs1470072012 2108 dbSNP
rs782079385 2119 dbSNP
rs1254059668 2156 dbSNP
rs1209741130 2166 dbSNP
rs1354930446 2202 dbSNP
rs1253604322 2205 dbSNP
rs868950550 2207 dbSNP
rs782712662 2213 dbSNP
rs1341577228 2220 dbSNP
rs1295633293 2239 dbSNP
rs1443434140 2241 dbSNP
rs1371434762 2268 dbSNP
rs1325042869 2282 dbSNP
rs1385000654 2311 dbSNP
rs781784067 2317 dbSNP
rs1168437808 2325 dbSNP
rs1460999923 2362 dbSNP
rs1387813322 2384 dbSNP
rs782150371 2394 dbSNP
rs1454479206 2395 dbSNP
rs1396052573 2402 dbSNP
rs1198521343 2417 dbSNP
rs1450253928 2426 dbSNP
rs1253230335 2469 dbSNP
rs1196921066 2470 dbSNP
rs1482752554 2480 dbSNP
rs1272634065 2490 dbSNP
rs1236756459 2506 dbSNP
rs1348955915 2507 dbSNP
rs1274489370 2535 dbSNP
rs782799978 2553 dbSNP
rs1230713900 2554 dbSNP
rs1337334089 2556 dbSNP
rs1329409783 2570 dbSNP
rs1368132119 2572 dbSNP
rs1314233979 2577 dbSNP
rs1044413 2592 dbSNP
rs1374412497 2598 dbSNP
rs150363963 2627 dbSNP
rs782602811 2631 dbSNP
rs1365956877 2641 dbSNP
rs781813555 2643 dbSNP
rs1472584841 2644 dbSNP
rs782440956 2680 dbSNP
rs782684311 2681 dbSNP
rs1486046460 2682 dbSNP
rs1278121696 2688 dbSNP
rs1198979335 2693 dbSNP
rs1352531471 2699 dbSNP
rs1279968725 2715 dbSNP
rs781869771 2716 dbSNP
rs1348626132 2720 dbSNP
rs146524049 2725 dbSNP
rs1414817588 2735 dbSNP
rs1358108333 2738 dbSNP
rs1331758744 2739 dbSNP
rs1402136843 2744 dbSNP
rs1387576604 2747 dbSNP
rs1159578671 2752 dbSNP
rs1457050081 2765 dbSNP
rs1410321573 2802 dbSNP
rs1190722157 2804 dbSNP
rs1475553339 2813 dbSNP
rs1237017297 2815 dbSNP
rs782148077 2817 dbSNP
rs1185657043 2823 dbSNP
rs782381460 2838 dbSNP
rs1207804744 2865 dbSNP
rs8805 2874 dbSNP
rs1326845708 2879 dbSNP
rs1274932105 2893 dbSNP
rs1233871435 2894 dbSNP
rs1377785970 2900 dbSNP
rs1281981155 2906 dbSNP
rs12391590 2907 dbSNP
rs1326584218 2909 dbSNP
rs1319489139 2916 dbSNP
rs1434760065 2930 dbSNP
rs782224277 2941 dbSNP
rs1386947003 2954 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001184742 | 3UTR | CCAUGUUAGCACUUUACUGCUGAAUUCUCAAUUUUCUUAACAUUGAGACAAUAAAUGUGUGUUUUGUCUUGUAUAUGGCAUAAAGAGUAAAUAAGUUUUAGAGUUGUUCUGGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_006777 | 3UTR | CAUUGAGACAAUAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_006777 | 3UTR | ACAUUGAGACAAUAAAUGUGUGUUUUGUCUUGUAUAUGGCAUAAAGAGUAAAUAAGUUUUAGAGUUGUUCUGGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_006777 | 3UTR | CUUAACAUUGAGACAAUAAAUGUGUGUUUUGUCUUGUAUAUGGCAUAAAGAGUAAAUAAGUUUUAGAGUUGUUCUGGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001184742 | 3UTR | AAAUGAUUAUUAUGAUUUUGGUGGUAACGAUCCCCCACACACAACCACUAUGAAGAAAUAAUGCCGCAUUUUUCCCCCAUUGUACCAAAAAGAUAAAAAAAUGGUAAACACUGAUCAAGGUAUUUUGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000326624.2 | 3UTR | AAAUGAUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
128 hsa-miR-4729 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055606 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT057816 SLC30A7 solute carrier family 30 member 7 2 2
MIRT061212 MED17 mediator complex subunit 17 2 2
MIRT071507 CALM1 calmodulin 1 2 6
MIRT072873 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT076728 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT087566 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 2
MIRT158563 TNRC6B trinucleotide repeat containing 6B 2 4
MIRT175514 ZBTB33 zinc finger and BTB domain containing 33 2 2
MIRT189775 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT198074 H3F3B H3 histone family member 3B 2 4
MIRT216059 IL6ST interleukin 6 signal transducer 2 10
MIRT219256 RREB1 ras responsive element binding protein 1 2 2
MIRT244716 INIP INTS3 and NABP interacting protein 2 2
MIRT271125 ZNF268 zinc finger protein 268 2 4
MIRT299114 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT303511 NAGK N-acetylglucosamine kinase 2 6
MIRT314695 TMEM167A transmembrane protein 167A 2 4
MIRT334550 AMOTL1 angiomotin like 1 2 4
MIRT441656 DEK DEK proto-oncogene 2 2
MIRT442232 BTD biotinidase 2 2
MIRT442418 LBR lamin B receptor 2 2
MIRT443352 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT444351 KIAA1211 KIAA1211 2 2
MIRT444910 KIAA1841 KIAA1841 2 2
MIRT448407 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT456345 OLIG3 oligodendrocyte transcription factor 3 2 8
MIRT467281 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT467925 SLC16A7 solute carrier family 16 member 7 2 2
MIRT468463 SET SET nuclear proto-oncogene 2 2
MIRT469438 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT475947 GXYLT1 glucoside xylosyltransferase 1 2 2
MIRT478069 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT479428 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT484710 RNF11 ring finger protein 11 2 2
MIRT491912 XIAP X-linked inhibitor of apoptosis 2 2
MIRT493551 HSPA5 heat shock protein family A (Hsp70) member 5 2 2
MIRT496126 ARF6 ADP ribosylation factor 6 2 2
MIRT500793 TLK1 tousled like kinase 1 2 6
MIRT504649 RPL9 ribosomal protein L9 2 6
MIRT513847 KCTD15 potassium channel tetramerization domain containing 15 2 4
MIRT519806 ZMYM2 zinc finger MYM-type containing 2 2 4
MIRT521156 SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 2 2
MIRT521919 PHIP pleckstrin homology domain interacting protein 2 4
MIRT522402 MYADM myeloid associated differentiation marker 2 4
MIRT526434 PARP15 poly(ADP-ribose) polymerase family member 15 2 4
MIRT526779 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT527864 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528063 OLAH oleoyl-ACP hydrolase 2 2
MIRT528640 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT529586 TMEM220 transmembrane protein 220 2 2
MIRT529810 TMLHE trimethyllysine hydroxylase, epsilon 2 2
MIRT531274 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT531430 MPZL3 myelin protein zero like 3 2 2
MIRT532141 ZNF331 zinc finger protein 331 2 2
MIRT535825 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT536253 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT537386 FGF2 fibroblast growth factor 2 2 2
MIRT543499 MDM2 MDM2 proto-oncogene 2 4
MIRT543564 RPF2 ribosome production factor 2 homolog 2 4
MIRT544457 KRBOX4 KRAB box domain containing 4 2 2
MIRT544902 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT545104 RAG1 recombination activating 1 2 2
MIRT546244 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT548287 FAM3C family with sequence similarity 3 member C 2 4
MIRT549268 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT550479 TMEM241 transmembrane protein 241 2 2
MIRT550657 ZFP37 ZFP37 zinc finger protein 2 2
MIRT551807 ITGA1 integrin subunit alpha 1 2 2
MIRT552582 ZFHX3 zinc finger homeobox 3 2 2
MIRT552671 YY1 YY1 transcription factor 2 4
MIRT553044 USP28 ubiquitin specific peptidase 28 2 2
MIRT553602 TM7SF3 transmembrane 7 superfamily member 3 2 2
MIRT553816 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT554618 RPS6KA3 ribosomal protein S6 kinase A3 2 2
MIRT556556 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT558290 DUSP8 dual specificity phosphatase 8 2 2
MIRT558487 DBN1 drebrin 1 2 2
MIRT559313 ATXN1 ataxin 1 2 2
MIRT560704 PRPF4B pre-mRNA processing factor 4B 2 2
MIRT562660 ARHGDIA Rho GDP dissociation inhibitor alpha 2 2
MIRT564158 ZNF117 zinc finger protein 117 2 2
MIRT564614 ZNF703 zinc finger protein 703 2 2
MIRT567236 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT568753 DDAH1 dimethylarginine dimethylaminohydrolase 1 2 2
MIRT570780 ZNF83 zinc finger protein 83 2 2
MIRT570919 ZNF138 zinc finger protein 138 2 2
MIRT571254 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT573776 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT574670 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT609759 TSPAN14 tetraspanin 14 2 2
MIRT613119 EID1 EP300 interacting inhibitor of differentiation 1 2 2
MIRT614384 FGFBP3 fibroblast growth factor binding protein 3 2 2
MIRT625801 MDC1 mediator of DNA damage checkpoint 1 2 2
MIRT634869 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT635723 ALKBH4 alkB homolog 4, lysine demethylase 2 2
MIRT636944 LIMS3 LIM zinc finger domain containing 3 2 2
MIRT637010 LIMS3L LIM zinc finger domain containing 4 2 2
MIRT639357 STPG1 sperm tail PG-rich repeat containing 1 2 2
MIRT640995 PROK2 prokineticin 2 2 2
MIRT641343 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT641495 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT642076 FUT11 fucosyltransferase 11 2 2
MIRT646837 TLDC1 TBC/LysM-associated domain containing 1 2 2
MIRT648154 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT650020 ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif 8 2 2
MIRT650603 HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 2 2
MIRT650624 GNB4 G protein subunit beta 4 2 2
MIRT652677 TIGD2 tigger transposable element derived 2 2 2
MIRT652721 TGFBRAP1 transforming growth factor beta receptor associated protein 1 2 2
MIRT654395 RBFOX2 RNA binding protein, fox-1 homolog 2 2 2
MIRT654659 PSPH phosphoserine phosphatase 2 2
MIRT654771 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 2 2
MIRT655696 NUDT21 nudix hydrolase 21 2 2
MIRT657635 GPRIN3 GPRIN family member 3 2 2
MIRT686214 ZNF267 zinc finger protein 267 2 2
MIRT690315 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT696323 DCAF15 DDB1 and CUL4 associated factor 15 2 2
MIRT697602 YAP1 Yes associated protein 1 2 2
MIRT702188 LYPD3 LY6/PLAUR domain containing 3 2 2
MIRT703577 FBXO9 F-box protein 9 2 2
MIRT707807 TSPAN6 tetraspanin 6 2 2
MIRT715951 CKAP2L cytoskeleton associated protein 2 like 2 2
MIRT716970 CNOT6 CCR4-NOT transcription complex subunit 6 2 2
MIRT718223 DEFB105B defensin beta 105B 2 2
MIRT718243 DEFB105A defensin beta 105A 2 2
MIRT719815 TXNDC17 thioredoxin domain containing 17 2 2
MIRT722082 SMC2 structural maintenance of chromosomes 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4729 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4729 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-4729 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-4729 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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