miRTarBase - #MIRT178942


—
pre-miRNA Information
pre-miRNA hsa-mir-4464   
Genomic Coordinates chr6: 90312742 - 90312833
Description Homo sapiens miR-4464 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4464
Sequence 12| AAGGUUUGGAUAGAUGCAAUA |32
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 6 + 90312764 29233923 MiREDiBase
A-to-I 14 6 + 90312766 29233923 MiREDiBase
A-to-I 19 6 + 90312771 29233923 MiREDiBase
A-to-I 21 6 + 90312773 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1240632245 2 dbSNP
rs34899210 2 dbSNP
rs1003034046 13 dbSNP
rs1475351324 14 dbSNP
rs1257582329 17 dbSNP
rs1193587810 20 dbSNP
Putative Targets

Gene Information
Gene Symbol C11orf57   
Synonyms -
Description chromosome 11 open reading frame 57
Transcript NM_001082969   
Other Transcripts NM_001082970 , NM_018195   
Expression
Putative miRNA Targets on C11orf57
3'UTR of C11orf57
(miRNA target sites are highlighted)		 
>C11orf57|NM_001082969|3'UTR
   1 ATGGGAAACACTTTTGTTTTCCACATGACTGTGGATATTTACAGTTCTTACTCCTTGTGGTTTTGCCAGTGACTCTTGTT
  81 CAGCACGGGGCCTGAGGTCAGAGCTGTCTTGTGCCATCTGTATGTTCTGACAGACGTCTTGTCTTCTATTTTGGCGTTAA
 161 GCTTGATCCCCTTTTCTTGTTAAAAGGGAATCTGGTATTTTGTTATGAAGGTTTCTTGAAGAGATTATTTTTTTTTGCAA
 241 TTAATTACGTTTAGTGTAGAGTGCATATACAGCAAATTAAAGGACCCAGAAAGCTGGATCCAATAGTGACCTGGGTACAC
 321 CAATCGGAATATTGAATTTGGGGAAGTCAAGGGCTGGGATCAAGAGGTGGATTGGAACTAATGCCATGTAGGATGGTATG
 401 ACAAGGCAACACTGTATTGCTCTCTGTTTATATAGCAGGTGTCACAACTAACTTGTCTTTAGCCTTGGTGCTTTGATCCT
 481 TCTATATTTTGACCCCACAGGTGTGGTCCGGTTTACTTAATCAGGACATGGGCCTAAGAACAAACCTTTTCCCTTCATGA
 561 TAACATCCATAGACAACTTATTAGAAGGGACTAGAGTTTTTGCAAATTTCCCTGCTGGATGGGGCCTATAGCTATACTTA
 641 GTATATGCCTAAACATGGTAATTGGATAGTAAATGGTTTTCTAGTTCCATTGCTGTATATTTGCCTAAATGGACTTGTGT
 721 TCAAATTATTTCTTCAATTGTCATAGATAATCCTGTACCAAATGGGGAAGAATTAGGAAATAATCATGTTGTCTAATGGT
 801 ACTCTGGATTCAGGGCAGCAACTGCCATTTAAATGTTGTCTTGTTCATTTCTAAATCTGTTCATGAAGTTTAGGTTTTCC
 881 CTGAAACTAAGTTGAATTATTTCCAAAATGAAACAGGCTTCTCAGGGACATATCCACTTCTTCCCAGTCTGCCTTTGGAT
 961 TAAAGCACCAAGCAGAGACCACATTAATTCCCTTTGCTATACTGTGATCCTTAGTATGTTAATTCTTAAGAAACCAACAT
1041 ATCACTGAAAGAAGGCTGGCAGAACGCAAGTGCATTTTTTCACTGTGGGAAGAAAGATCAAGTGACGTATTATTTTTTCC
1121 TGGTTGTCACTTAATGGGCTGAGTAAAAAGCTTGAAAACTCAGACTTTCGGTCTTGGTTCTGCCACTCATTGGTTATGAG
1201 GAGGCCCAGAGCAGGTAAGTTCACCTTCCTGGCCTTACTTTCCTGATGTGTAATACGGAATTACTTCACAGTAGCATGAC
1281 AGTATAAGACACCAGCAGTAGATACAACTATGATGACATTCCATGAGTTGGTATTTTTAGTTCTAACTGCTAAATTTGTT
1361 CTCTTTACGGGACAGATTTCTAATAAAGTGCTTGGTCTTAAAATACATGGTTGGACAGAGGTGCCCTATCCCTTAACTAT
1441 GAGCAGGTGCTACCTTTTGGGATATTTATTTTAAATTTTAATACTTTGGTACTCAATTGTCAGTGTTCCATGGTGTGTAT
1521 TTTTATTTTTGGGATTAGTGGGGGTCTAAAGGGAGAAGAATAGTCTCTAATTACTACCTCTTAACCTAAAGCAATTATTT
1601 TGTTCCTGGAGCAAGTTAAATCTTTGTTGGAAGGAGCTTTGGCCATATATTTTTTAGCATGCATTGTTTCTGTGCCCTGA
1681 AAGTACCTGAAAGGTTTTAAGCACAGACTCAGGAAAATGTGCCAGTAGAACAGGCCATCTCCAGGAAATTGGCTCTATTT
1761 GGGTCCTGACCTTCCCTTCCTCCCAAGTTAGCAGGCTTGTTCTTTCGCAAGGAATACACATCTTGCCTTTTTTTTTTTTT
1841 TTTTGCCATGTTTTCCTTTTCTTGGTCATGTATAAGCAATAAAGCTGTTTTTTGTTCTTCATCTTTCTTAACCCCAAATT
1921 TTCTTCTATGCCTTAGGCTTCGATGGTTCTTCCAACCCCCTTAATATGGCTTAGGGTGGTTTTTCAAAACCTACAATCCC
2001 CCATTTGCACTACTGGCCATGGAACATTTATTTCTAGTGTTCCTGCCAATCAGAGATCTCTATATTAAATTCTAAAATGG
2081 GATTAAAAGAAGAGTTGGAGAATTCACACTTATTGAGTAACTGATGTCATACAACCTGGAATTTCTGAATTCCAAATAAA
2161 TAAATTTCACTCTTTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auaACGUAGAU--AGGUUUGGAa 5'
             || : |||    ||||||| 
Target 5' acaTGGGCCTAAGAACAAACCTt 3'
 526 - 548 144.00 -10.50
2 
miRNA  3' auAACGUAG-AUAGGUUUGGAa 5'
            |||: || | ||:|||:|| 
Target 5' tcTTGT-TCATTTCTAAATCTg 3'
 839 - 859 130.00 -8.00
3 
miRNA  3' auaACGUAGAUAGGUUUGGAa 5'
             || :|:| || |||||| 
Target 5' gggTG-GTTTTTCAAAACCTa 3'
 1974 - 1993 129.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30468802 22 COSMIC
COSN30496322 27 COSMIC
COSN30478824 34 COSMIC
COSN5894928 55 COSMIC
COSN20714493 109 COSMIC
COSN1126581 117 COSMIC
COSN28635960 157 COSMIC
COSN20108752 228 COSMIC
COSN31480653 298 COSMIC
COSN26548486 665 COSMIC
COSN26481311 670 COSMIC
COSN22510958 839 COSMIC
COSN31565913 861 COSMIC
COSN31595868 919 COSMIC
COSN25186496 931 COSMIC
COSN20092428 1003 COSMIC
COSN26677544 1005 COSMIC
COSN30174929 1097 COSMIC
COSN30174906 1210 COSMIC
COSN26603475 1220 COSMIC
COSN31570889 1259 COSMIC
COSN1513976 1475 COSMIC
COSN20850543 1587 COSMIC
COSN31532210 1656 COSMIC
COSN15775008 1750 COSMIC
COSN28629879 1788 COSMIC
COSN19655815 1828 COSMIC
COSN8640852 1847 COSMIC
COSN25730499 1905 COSMIC
COSN30160456 1915 COSMIC
COSN31515154 1943 COSMIC
COSN31532515 1991 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1209962072 2 dbSNP
rs755604045 12 dbSNP
rs777195210 12 dbSNP
rs765143210 14 dbSNP
rs748936506 15 dbSNP
rs750277315 16 dbSNP
rs1202438277 18 dbSNP
rs780386648 21 dbSNP
rs747187438 22 dbSNP
rs770552419 25 dbSNP
rs1224517489 28 dbSNP
rs554244479 30 dbSNP
rs945358187 30 dbSNP
rs1413718389 32 dbSNP
rs1042406415 34 dbSNP
rs1332061889 35 dbSNP
rs1377160210 36 dbSNP
rs1415371392 39 dbSNP
rs1306858347 43 dbSNP
rs755066399 48 dbSNP
rs745599272 50 dbSNP
rs1384114187 52 dbSNP
rs538957501 53 dbSNP
rs1362799558 61 dbSNP
rs759111779 68 dbSNP
rs1336198960 71 dbSNP
rs1450478797 73 dbSNP
rs1403821606 75 dbSNP
rs1320577808 76 dbSNP
rs925306939 77 dbSNP
rs1357762941 84 dbSNP
rs1372266220 87 dbSNP
rs77521375 87 dbSNP
rs772078987 88 dbSNP
rs889951758 100 dbSNP
rs1459538903 106 dbSNP
rs1008406614 108 dbSNP
rs1245589249 114 dbSNP
rs1204855399 115 dbSNP
rs113433885 119 dbSNP
rs981662129 122 dbSNP
rs1230020866 126 dbSNP
rs1308326274 129 dbSNP
rs1041278114 133 dbSNP
rs769430712 134 dbSNP
rs1396503170 136 dbSNP
rs773635177 136 dbSNP
rs1277248219 137 dbSNP
rs1296259568 140 dbSNP
rs956476151 141 dbSNP
rs993804682 157 dbSNP
rs1442307398 161 dbSNP
rs914200741 163 dbSNP
rs1026636829 164 dbSNP
rs577670821 174 dbSNP
rs1188900677 175 dbSNP
rs952524730 178 dbSNP
rs1437792942 180 dbSNP
rs947171351 188 dbSNP
rs540235628 197 dbSNP
rs1034523409 202 dbSNP
rs959827986 206 dbSNP
rs1483583310 207 dbSNP
rs911062965 212 dbSNP
rs1220507167 215 dbSNP
rs1491340302 226 dbSNP
rs201034800 227 dbSNP
rs3839946 227 dbSNP
rs1238353082 228 dbSNP
rs62775862 228 dbSNP
rs1304695538 234 dbSNP
rs943894015 235 dbSNP
rs1462552303 237 dbSNP
rs1179649866 240 dbSNP
rs1232341540 241 dbSNP
rs1370928158 241 dbSNP
rs1470581467 243 dbSNP
rs1040889505 245 dbSNP
rs377091190 249 dbSNP
rs560260014 250 dbSNP
rs1469132456 252 dbSNP
rs1362574973 255 dbSNP
rs149392861 292 dbSNP
rs1268585387 293 dbSNP
rs1423276225 304 dbSNP
rs375736544 305 dbSNP
rs1047739535 311 dbSNP
rs979109045 314 dbSNP
rs763905998 316 dbSNP
rs10255 321 dbSNP
rs542735990 322 dbSNP
rs1204632889 326 dbSNP
rs887745167 327 dbSNP
rs1258954301 328 dbSNP
rs1177526581 341 dbSNP
rs1241076793 344 dbSNP
rs1350930203 345 dbSNP
rs925303211 346 dbSNP
rs1282432126 347 dbSNP
rs1402820185 349 dbSNP
rs936700391 354 dbSNP
rs1323735975 367 dbSNP
rs1049799935 370 dbSNP
rs562541234 375 dbSNP
rs1022966122 383 dbSNP
rs188149070 389 dbSNP
rs970113520 392 dbSNP
rs192713438 394 dbSNP
rs911310723 395 dbSNP
rs184466504 413 dbSNP
rs1036250851 415 dbSNP
rs1481583613 417 dbSNP
rs1247576291 418 dbSNP
rs766944608 420 dbSNP
rs989440619 420 dbSNP
rs1041246286 427 dbSNP
rs897356945 439 dbSNP
rs1209399216 442 dbSNP
rs968336480 448 dbSNP
rs1343182540 457 dbSNP
rs1221470195 459 dbSNP
rs994427609 471 dbSNP
rs1275121239 472 dbSNP
rs1263513934 473 dbSNP
rs1049156873 474 dbSNP
rs761729307 480 dbSNP
rs1429551849 489 dbSNP
rs767354901 492 dbSNP
rs888086802 497 dbSNP
rs1325503037 501 dbSNP
rs1001611977 502 dbSNP
rs911010845 510 dbSNP
rs190574277 511 dbSNP
rs1193981742 512 dbSNP
rs181924990 521 dbSNP
rs1471192828 531 dbSNP
rs1426289521 533 dbSNP
rs11546875 552 dbSNP
rs918394022 558 dbSNP
rs959796040 561 dbSNP
rs1013991020 564 dbSNP
rs75262267 570 dbSNP
rs144786392 571 dbSNP
rs766325560 574 dbSNP
rs1279101423 580 dbSNP
rs1431861275 582 dbSNP
rs1460836167 595 dbSNP
rs1337056675 598 dbSNP
rs1167724076 610 dbSNP
rs1381383783 610 dbSNP
rs138507332 613 dbSNP
rs369867535 614 dbSNP
rs184242653 622 dbSNP
rs1360211479 638 dbSNP
rs984275280 645 dbSNP
rs1408518783 647 dbSNP
rs559247624 651 dbSNP
rs1035874820 652 dbSNP
rs1330248182 657 dbSNP
rs1444150310 661 dbSNP
rs572797447 665 dbSNP
rs985881997 666 dbSNP
rs911279440 674 dbSNP
rs944090397 680 dbSNP
rs1403948884 688 dbSNP
rs117042730 689 dbSNP
rs1203562668 689 dbSNP
rs1435860944 695 dbSNP
rs1010488661 696 dbSNP
rs1347031810 710 dbSNP
rs1358158940 715 dbSNP
rs1312319132 719 dbSNP
rs1022331694 720 dbSNP
rs1380553417 730 dbSNP
rs1279422047 738 dbSNP
rs968949517 740 dbSNP
rs754994964 741 dbSNP
rs570373153 744 dbSNP
rs1308904927 746 dbSNP
rs143907986 757 dbSNP
rs1363888705 765 dbSNP
rs147281084 766 dbSNP
rs888715066 770 dbSNP
rs1405959487 795 dbSNP
rs1414529991 798 dbSNP
rs1468452166 805 dbSNP
rs1253669768 807 dbSNP
rs542349863 812 dbSNP
rs1182584741 818 dbSNP
rs965144812 822 dbSNP
rs140693312 832 dbSNP
rs1490217546 836 dbSNP
rs1223139063 850 dbSNP
rs1055378150 855 dbSNP
rs142285332 868 dbSNP
rs929760565 876 dbSNP
rs1265629287 877 dbSNP
rs1013955039 893 dbSNP
rs909836950 895 dbSNP
rs947954936 896 dbSNP
rs1044393648 900 dbSNP
rs1437352877 907 dbSNP
rs1374008519 909 dbSNP
rs905842970 920 dbSNP
rs1455605982 922 dbSNP
rs1414033386 931 dbSNP
rs758517770 934 dbSNP
rs1476668094 936 dbSNP
rs1479952327 951 dbSNP
rs938786117 957 dbSNP
rs1192560465 965 dbSNP
rs1020023524 967 dbSNP
rs1241047274 970 dbSNP
rs1057452483 972 dbSNP
rs902980548 991 dbSNP
rs1000436736 1003 dbSNP
rs1032903941 1014 dbSNP
rs752359440 1014 dbSNP
rs778105799 1015 dbSNP
rs747320776 1021 dbSNP
rs1303741289 1024 dbSNP
rs1387531987 1039 dbSNP
rs1423400825 1043 dbSNP
rs1303264232 1052 dbSNP
rs1021780017 1057 dbSNP
rs1287214915 1058 dbSNP
rs904802816 1060 dbSNP
rs1380182656 1062 dbSNP
rs1007126284 1063 dbSNP
rs986093505 1066 dbSNP
rs1469156881 1067 dbSNP
rs544829028 1068 dbSNP
rs965404929 1069 dbSNP
rs150580658 1075 dbSNP
rs879834467 1075 dbSNP
rs754828894 1082 dbSNP
rs1358674794 1092 dbSNP
rs139628417 1094 dbSNP
rs918678663 1096 dbSNP
rs930136908 1102 dbSNP
rs369264075 1107 dbSNP
rs73568080 1108 dbSNP
rs1262861922 1113 dbSNP
rs910081805 1120 dbSNP
rs1025855173 1146 dbSNP
rs746388981 1150 dbSNP
rs1293617949 1152 dbSNP
rs752086870 1160 dbSNP
rs757980223 1162 dbSNP
rs765664632 1162 dbSNP
rs1366009997 1168 dbSNP
rs1056014261 1170 dbSNP
rs895476464 1171 dbSNP
rs1236662570 1174 dbSNP
rs769377402 1174 dbSNP
rs949726761 1177 dbSNP
rs909694736 1183 dbSNP
rs1304383566 1185 dbSNP
rs1466298115 1191 dbSNP
rs1445767505 1198 dbSNP
rs765094137 1198 dbSNP
rs1450846014 1203 dbSNP
rs777378476 1212 dbSNP
rs1390220845 1217 dbSNP
rs1139693 1224 dbSNP
rs902948438 1225 dbSNP
rs1182397803 1227 dbSNP
rs561120601 1234 dbSNP
rs1000003560 1235 dbSNP
rs1201395639 1240 dbSNP
rs1163602609 1247 dbSNP
rs1249895908 1249 dbSNP
rs1033245045 1250 dbSNP
rs980621337 1251 dbSNP
rs1343017222 1257 dbSNP
rs559141148 1258 dbSNP
rs1139692 1269 dbSNP
rs927299483 1274 dbSNP
rs1314760766 1278 dbSNP
rs530146695 1279 dbSNP
rs1372314840 1280 dbSNP
rs549964939 1284 dbSNP
rs775167892 1285 dbSNP
rs1370737067 1286 dbSNP
rs1157672549 1293 dbSNP
rs1455877308 1295 dbSNP
rs1057123419 1298 dbSNP
rs746717114 1300 dbSNP
rs1418914607 1304 dbSNP
rs1250030238 1305 dbSNP
rs1184739145 1306 dbSNP
rs1385368082 1320 dbSNP
rs1483510728 1321 dbSNP
rs965333990 1322 dbSNP
rs1436951724 1332 dbSNP
rs188971213 1333 dbSNP
rs946137138 1343 dbSNP
rs532724905 1346 dbSNP
rs1025706881 1353 dbSNP
rs904665338 1357 dbSNP
rs1245389580 1358 dbSNP
rs1317240213 1358 dbSNP
rs552819545 1359 dbSNP
rs181665407 1369 dbSNP
rs1411370842 1390 dbSNP
rs1350736575 1391 dbSNP
rs984246739 1400 dbSNP
rs1384630879 1405 dbSNP
rs1261585953 1409 dbSNP
rs1353145766 1412 dbSNP
rs535331966 1417 dbSNP
rs910040263 1424 dbSNP
rs774123547 1429 dbSNP
rs991665749 1430 dbSNP
rs1413228326 1438 dbSNP
rs917500600 1451 dbSNP
rs1453718533 1452 dbSNP
rs949696135 1453 dbSNP
rs1410339787 1463 dbSNP
rs1041377681 1470 dbSNP
rs576245355 1476 dbSNP
rs901423317 1481 dbSNP
rs935730801 1488 dbSNP
rs1025295337 1502 dbSNP
rs555285281 1511 dbSNP
rs888912997 1514 dbSNP
rs1005272147 1518 dbSNP
rs1186033900 1527 dbSNP
rs761451653 1531 dbSNP
rs1257616741 1538 dbSNP
rs1328407827 1540 dbSNP
rs1007402439 1542 dbSNP
rs567111887 1547 dbSNP
rs7123075 1553 dbSNP
rs1157757777 1554 dbSNP
rs901775139 1559 dbSNP
rs1230578586 1568 dbSNP
rs927917605 1575 dbSNP
rs960641626 1588 dbSNP
rs993258764 1603 dbSNP
rs1458495964 1607 dbSNP
rs1458137456 1608 dbSNP
rs993444031 1611 dbSNP
rs1171144750 1618 dbSNP
rs750313050 1627 dbSNP
rs1378363638 1628 dbSNP
rs1192569925 1632 dbSNP
rs1463599013 1642 dbSNP
rs1246177273 1650 dbSNP
rs946138471 1662 dbSNP
rs768988568 1667 dbSNP
rs1277697235 1669 dbSNP
rs1405159952 1677 dbSNP
rs555959690 1680 dbSNP
rs1346704383 1687 dbSNP
rs1470250548 1691 dbSNP
rs1227103916 1697 dbSNP
rs1476565154 1700 dbSNP
rs1304556132 1702 dbSNP
rs951454678 1703 dbSNP
rs1043131127 1705 dbSNP
rs1436503826 1706 dbSNP
rs775098504 1714 dbSNP
rs1405930232 1722 dbSNP
rs1332621808 1729 dbSNP
rs1416453176 1732 dbSNP
rs1390851247 1733 dbSNP
rs1403264584 1734 dbSNP
rs868180901 1737 dbSNP
rs576106750 1738 dbSNP
rs1447786800 1742 dbSNP
rs1392067001 1750 dbSNP
rs370443493 1755 dbSNP
rs1391370939 1756 dbSNP
rs760637489 1757 dbSNP
rs1017024398 1758 dbSNP
rs1206096466 1760 dbSNP
rs1278952192 1762 dbSNP
rs1039888647 1766 dbSNP
rs958824360 1767 dbSNP
rs1339585991 1773 dbSNP
rs1276181037 1787 dbSNP
rs544184 1788 dbSNP
rs1282939288 1793 dbSNP
rs1450707183 1797 dbSNP
rs998429972 1798 dbSNP
rs3740971 1802 dbSNP
rs1428101345 1803 dbSNP
rs1372593191 1806 dbSNP
rs10812 1807 dbSNP
rs1424026744 1808 dbSNP
rs977666668 1822 dbSNP
rs924268850 1824 dbSNP
rs1005260403 1826 dbSNP
rs1220980485 1826 dbSNP
rs1237869166 1827 dbSNP
rs1302122468 1827 dbSNP
rs1329047828 1827 dbSNP
rs1308846741 1828 dbSNP
rs1352572515 1828 dbSNP
rs1402149144 1828 dbSNP
rs1408329948 1828 dbSNP
rs1491043662 1828 dbSNP
rs373899267 1828 dbSNP
rs386374911 1828 dbSNP
rs71301698 1828 dbSNP
rs71775703 1828 dbSNP
rs751174110 1828 dbSNP
rs1196925140 1843 dbSNP
rs1016677630 1844 dbSNP
rs1348166878 1844 dbSNP
rs1428300772 1844 dbSNP
rs1166948496 1845 dbSNP
rs867719695 1846 dbSNP
rs1265997378 1847 dbSNP
rs1466032078 1848 dbSNP
rs1352621133 1850 dbSNP
rs889400058 1851 dbSNP
rs4937011 1852 dbSNP
rs1298805506 1854 dbSNP
rs1372560364 1855 dbSNP
rs1403299152 1856 dbSNP
rs878991213 1862 dbSNP
rs942034386 1865 dbSNP
rs1221251696 1866 dbSNP
rs191295421 1873 dbSNP
rs1182423511 1874 dbSNP
rs1487897530 1884 dbSNP
rs1244508463 1886 dbSNP
rs1307370037 1895 dbSNP
rs969101014 1897 dbSNP
rs1205905473 1898 dbSNP
rs1267985676 1900 dbSNP
rs1274729466 1901 dbSNP
rs1227018961 1902 dbSNP
rs1483773997 1902 dbSNP
rs1219773682 1904 dbSNP
rs1331635222 1910 dbSNP
rs1054574290 1915 dbSNP
rs1002020406 1918 dbSNP
rs1034795420 1931 dbSNP
rs180822823 1932 dbSNP
rs1437197770 1937 dbSNP
rs754468787 1942 dbSNP
rs960928996 1943 dbSNP
rs910321086 1948 dbSNP
rs1192651193 1952 dbSNP
rs1413863802 1956 dbSNP
rs1159577844 1957 dbSNP
rs1432260525 1958 dbSNP
rs529995315 1964 dbSNP
rs1040220215 1968 dbSNP
rs1248016439 1975 dbSNP
rs988049367 1977 dbSNP
rs1417199134 1978 dbSNP
rs1427844225 1980 dbSNP
rs913233035 1984 dbSNP
rs1209783246 1992 dbSNP
rs879550102 1992 dbSNP
rs879628508 1995 dbSNP
rs1303669581 1997 dbSNP
rs1219946439 1998 dbSNP
rs758562999 2000 dbSNP
rs967366221 2003 dbSNP
rs901701647 2005 dbSNP
rs1432852939 2012 dbSNP
rs926061914 2015 dbSNP
rs777852724 2016 dbSNP
rs1289247519 2018 dbSNP
rs1465303746 2023 dbSNP
rs543821094 2025 dbSNP
rs1392071291 2027 dbSNP
rs1177779786 2039 dbSNP
rs1434839625 2040 dbSNP
rs751809666 2048 dbSNP
rs1422765310 2054 dbSNP
rs563596712 2059 dbSNP
rs149707049 2063 dbSNP
rs1017408830 2064 dbSNP
rs958793802 2075 dbSNP
rs1181709207 2078 dbSNP
rs1438897575 2082 dbSNP
rs934244162 2085 dbSNP
rs1047270065 2086 dbSNP
rs1341674881 2087 dbSNP
rs887353472 2093 dbSNP
rs1230631277 2094 dbSNP
rs1367274306 2099 dbSNP
rs1296206672 2110 dbSNP
rs1395303657 2110 dbSNP
rs1012982267 2114 dbSNP
rs1304326142 2116 dbSNP
rs1434969520 2116 dbSNP
rs1369492422 2118 dbSNP
rs1166176942 2126 dbSNP
rs1037669533 2132 dbSNP
rs146725060 2133 dbSNP
rs971576711 2135 dbSNP
rs1037985966 2136 dbSNP
rs904972407 2164 dbSNP
rs1258739610 2170 dbSNP
rs978069166 2171 dbSNP
rs1001883229 2173 dbSNP
rs140364026 2176 dbSNP
rs1249811117 2177 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000532163.1 | 3UTR | UUUUUCAAAACCUACAAUCCCCCAUUUGCACUACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
81 hsa-miR-4464 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056004 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT061568 BTG2 BTG anti-proliferation factor 2 2 2
MIRT078651 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT087551 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 4
MIRT088139 SEPT2 septin 2 2 4
MIRT095089 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT099065 FOXC1 forkhead box C1 2 4
MIRT150194 MIDN midnolin 2 2
MIRT178173 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT178942 C11ORF57 chromosome 11 open reading frame 57 2 2
MIRT188776 SESN2 sestrin 2 2 2
MIRT267026 EFHD2 EF-hand domain family member D2 2 2
MIRT307213 ACVR2B activin A receptor type 2B 2 2
MIRT324750 ACER2 alkaline ceramidase 2 2 2
MIRT442732 TEAD1 TEA domain transcription factor 1 2 2
MIRT444087 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT445527 KLF9 Kruppel like factor 9 2 2
MIRT449604 INIP INTS3 and NABP interacting protein 2 2
MIRT451129 ZNF99 zinc finger protein 99 2 2
MIRT452271 RPL30 ribosomal protein L30 2 2
MIRT452486 DDX4 DEAD-box helicase 4 2 2
MIRT454868 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 2 6
MIRT455773 TSPAN6 tetraspanin 6 2 4
MIRT463844 WRN Werner syndrome RecQ like helicase 2 2
MIRT465036 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT465176 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT465294 TRIB3 tribbles pseudokinase 3 2 4
MIRT467931 SLC16A7 solute carrier family 16 member 7 2 2
MIRT471906 NUAK2 NUAK family kinase 2 2 2
MIRT472724 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT479785 CCND1 cyclin D1 2 2
MIRT482446 ADM adrenomedullin 2 10
MIRT485365 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT498399 KIF6 kinesin family member 6 2 2
MIRT503202 ACTB actin beta 2 6
MIRT503819 TMEM242 transmembrane protein 242 2 2
MIRT504706 ZNF117 zinc finger protein 117 2 2
MIRT507802 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT509968 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 4
MIRT517306 ELF4 E74 like ETS transcription factor 4 2 6
MIRT523900 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT532018 NOX5 NADPH oxidase 5 2 2
MIRT535334 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT536944 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 4
MIRT539322 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT540189 GSTM4 glutathione S-transferase mu 4 2 2
MIRT545015 ZNF439 zinc finger protein 439 2 2
MIRT545265 TRIM36 tripartite motif containing 36 2 4
MIRT547230 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 4
MIRT548425 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT549910 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550185 TMEM106C transmembrane protein 106C 2 2
MIRT550775 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT552401 ZNF487P zinc finger protein 487 1 1
MIRT554782 RHEBP1 RHEB pseudogene 1 2 4
MIRT557311 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT558635 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT563168 RPS14 ribosomal protein S14 2 2
MIRT564886 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT565778 SEPHS1 selenophosphate synthetase 1 2 2
MIRT566480 PDCD4 programmed cell death 4 2 2
MIRT567206 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568931 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT570698 FBXO41 F-box protein 41 2 2
MIRT573474 MTRNR2L9 MT-RNR2-like 9 2 2
MIRT576170 Hmox1 heme oxygenase 1 2 2
MIRT607555 GLI2 GLI family zinc finger 2 2 2
MIRT608203 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609779 VWC2L von Willebrand factor C domain containing protein 2 like 2 4
MIRT616312 CELF2 CUGBP Elav-like family member 2 2 2
MIRT617190 CDH13 cadherin 13 2 2
MIRT626842 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT636438 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT639101 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT691018 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT700008 RPS21 ribosomal protein S21 2 2
MIRT701144 PANK1 pantothenate kinase 1 2 2
MIRT712691 NUDT7 nudix hydrolase 7 2 2
MIRT715505 MAZ MYC associated zinc finger protein 2 2
MIRT722509 PTPRC protein tyrosine phosphatase, receptor type C 2 2
MIRT724982 TNS1 tensin 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4464 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4464 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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