miRTarBase - #MIRT179641


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pre-miRNA Information
pre-miRNA hsa-mir-4534   
Genomic Coordinates chr22: 37988794 - 37988853
Description Homo sapiens miR-4534 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4534
Sequence 36| GGAUGGAGGAGGGGUCU |52
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs890798116 2 dbSNP
rs1382774432 11 dbSNP
rs982883970 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CAPZA1   
Synonyms CAPPA1, CAPZ, CAZ1
Description capping actin protein of muscle Z-line alpha subunit 1
Transcript NM_006135   
Expression
Putative miRNA Targets on CAPZA1
3'UTR of CAPZA1
(miRNA target sites are highlighted)		 
>CAPZA1|NM_006135|3'UTR
   1 AGGCTGAATGTAGGATTCTTCAGTATGTGGAAAGACAAGGATTCAACGTGTGGTCATATGATAAATAAGTGATTTATAAA
  81 CAAGAGTGATATTTTGCTAGGGCTTTCAAAGTTAACCGGTTTTCTAGCCTCATGGAATACTGTTGAACCTATAGCGTTGT
 161 CTTGATTCTTTTGTGTTCTCTGCCTTGTAATTTTCTGTTACTGCTATATCTACGTGTAAATCTTTTTTTCTTTTTTTTTT
 241 TTTTTTTTTGGTTAATTCTGCCACATTTAATGTTGGTGAGAGAGTGATCTATCCTAATGACATTTTACTGTTTAAAAAAG
 321 TTTCCTAGCCATGAAGCCCTGCTACTGATTTAGACAAGGTATTATGGTCATTACTTTGTACCCCTATCCTTCCAAGCACT
 401 TCTGGTACTTCAGTCGTTTTTACTGATCCACCAACACCTAAAGAGGCTATGCTACAGTCTCTAGCTAAATGGAAGACACA
 481 TTCATCCTTCTCCCTCTGACTGCTTTGATCATCATTTATTGCATCTCATAACTAATTTTCTAAAGTTTGGATTGGGACTT
 561 TTCAGGTCCTTTTTGGAGGGCAAAGGAAGTGCCAGCTTCTCTGGGGAACTTGTTTTTAAATCCAAAGACTTGAACCACAT
 641 TCCCTGCACATGAACATGTTTGCTTTTATCCCTTCTCTCATTGTCTCCTTCCCATCTTAGTACCATTGTAGTTATAAACA
 721 TCTGCATTTTTTAGAAGCATTTTACCCATTTATTTTTTTAAACATTCAAGAACTGCTGACGTACTGTGGATGTAGAGTAT
 801 AAAACTTGAAAAATGCAGATGTTGAAGGAATAATAGGTATCTTGTGCTTTAATACTTTATGGCAGGATTGTACTATAAGC
 881 AAATGAATTAAACAGCTATGTAAATCATAAAGAAAAACTAAAAATGAACCAAAGTGAAAGGATAACTTCCAGGCAGTATC
 961 TTTCTATTGTAACCTGTTATTTAAGGAAATACTAGTGATTTCTTCTAAATAGGATGTAAAACTTCTTTCAAATTACTCTT
1041 CCTCAGTCCTGCCTGCCAAGAACTCAAGTGTAACTGTGATAAAATAACCTTTCCCAGGTATATTGGCAGGTATGTGTGTA
1121 ATCTCAGAATACACAGGTGACATAGATATGATATGACAACTGGTAATGGTGGATTCATTTACATTGTTTACACTTCTATG
1201 ACCAGGCCTTAAGGGAAGGTCAGTTTTTTAAAAAACCAAGTAGTGTCTTCCTACCTATCTCCAGATACATGTCAAAAAAA
1281 GAAAGGTGTTTGTGCTTCCGTTTTGTTTCTGCTCAGTAATATAGTCAAGCAAGTTTGTTCCAGGTGACCCATTGAGCTGT
1361 GTATGCATTTTTGTTTATTTCAATAAAATATATTTGTATTATTTGTCCTTCATACTATCCATCCATACCACACTATCTTC
1441 TGTATCAGGTAGTCTAATAGAAATATACCTGTTTTGTTCTAAAATTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucugGGGAGGAGGUAGg 5'
              :|||:|||| || 
Target 5' ttcaTCCTTCTCCCTCt 3'
 481 - 497 125.00 -15.80
2 
miRNA  3' ucuggggaggAGGUAGg 5'
                    |||||| 
Target 5' cttcatactaTCCATCc 3'
 1408 - 1424 120.00 -12.00
3 
miRNA  3' ucUGGGGAGGAG-GUAGg 5'
            |:||||:||| |||: 
Target 5' ttATCCCTTCTCTCATTg 3'
 666 - 683 119.00 -17.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30476136 3 COSMIC
COSN30519808 11 COSMIC
COSN30106382 14 COSMIC
COSN26969173 26 COSMIC
COSN30501286 35 COSMIC
COSN31554587 42 COSMIC
COSN31492030 68 COSMIC
COSN31660610 84 COSMIC
COSN30511086 89 COSMIC
COSN31547183 179 COSMIC
COSN1087163 231 COSMIC
COSN31583907 235 COSMIC
COSN30162986 236 COSMIC
COSN26647088 648 COSMIC
COSN16199969 688 COSMIC
COSN31544453 751 COSMIC
COSN31483078 812 COSMIC
COSN30391737 976 COSMIC
COSN31480869 998 COSMIC
COSN16390141 1149 COSMIC
COSN26158725 1254 COSMIC
COSN5353051 1414 COSMIC
COSN31490644 1443 COSMIC
COSN31596271 1445 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs760135290 3 dbSNP
rs765798874 7 dbSNP
rs1295029251 10 dbSNP
rs1212849862 11 dbSNP
rs1319460381 12 dbSNP
rs1220980231 14 dbSNP
rs1256761871 21 dbSNP
rs752864875 23 dbSNP
rs1210764952 24 dbSNP
rs375232761 25 dbSNP
rs368445388 26 dbSNP
rs551198154 29 dbSNP
rs1263977438 37 dbSNP
rs199650232 38 dbSNP
rs1040595141 43 dbSNP
rs1169189691 47 dbSNP
rs780975520 48 dbSNP
rs200171825 49 dbSNP
rs1443570098 57 dbSNP
rs1241103544 69 dbSNP
rs1178721782 79 dbSNP
rs1049248507 82 dbSNP
rs1363570114 87 dbSNP
rs1250670969 92 dbSNP
rs1437907362 92 dbSNP
rs371240455 116 dbSNP
rs1361725916 117 dbSNP
rs530446657 118 dbSNP
rs1245540829 124 dbSNP
rs1296686455 126 dbSNP
rs1330863170 130 dbSNP
rs1309695646 131 dbSNP
rs1392305028 134 dbSNP
rs879857260 138 dbSNP
rs185470302 141 dbSNP
rs1022747302 144 dbSNP
rs1366908393 150 dbSNP
rs1257981256 153 dbSNP
rs369766070 156 dbSNP
rs1208127202 157 dbSNP
rs1183784206 160 dbSNP
rs1266322760 161 dbSNP
rs1419478259 165 dbSNP
rs1373080016 171 dbSNP
rs971050480 172 dbSNP
rs189899505 179 dbSNP
rs1490804334 181 dbSNP
rs1269768756 191 dbSNP
rs1221843324 198 dbSNP
rs1357616314 201 dbSNP
rs1262735257 206 dbSNP
rs1239977495 207 dbSNP
rs552801804 212 dbSNP
rs566557789 214 dbSNP
rs538790200 215 dbSNP
rs1266642633 221 dbSNP
rs1188815731 223 dbSNP
rs1204251382 223 dbSNP
rs1387891563 223 dbSNP
rs140993095 223 dbSNP
rs1453938218 223 dbSNP
rs1156673395 227 dbSNP
rs1363027378 227 dbSNP
rs1481417733 229 dbSNP
rs1198533164 230 dbSNP
rs370084665 230 dbSNP
rs1002575883 231 dbSNP
rs1283229776 231 dbSNP
rs1318345157 231 dbSNP
rs1319656222 231 dbSNP
rs1382495213 231 dbSNP
rs1383790004 231 dbSNP
rs1429679233 231 dbSNP
rs1433630786 231 dbSNP
rs1491207719 231 dbSNP
rs58051216 231 dbSNP
rs72984526 231 dbSNP
rs753090322 231 dbSNP
rs1491091948 232 dbSNP
rs1200815442 233 dbSNP
rs1031965417 234 dbSNP
rs199782772 235 dbSNP
rs1271500751 236 dbSNP
rs72984529 236 dbSNP
rs1325545472 237 dbSNP
rs990358474 237 dbSNP
rs1335822493 238 dbSNP
rs1406557026 238 dbSNP
rs1021442891 239 dbSNP
rs1156231187 239 dbSNP
rs1390244517 243 dbSNP
rs1398503035 249 dbSNP
rs1298711396 250 dbSNP
rs1194448446 251 dbSNP
rs371510141 252 dbSNP
rs3103452 253 dbSNP
rs1289932384 254 dbSNP
rs1390731036 255 dbSNP
rs1428338418 256 dbSNP
rs1385445120 259 dbSNP
rs1303882172 261 dbSNP
rs1388359339 273 dbSNP
rs557988674 283 dbSNP
rs574588878 289 dbSNP
rs1445405191 298 dbSNP
rs1242984677 320 dbSNP
rs954037232 331 dbSNP
rs1440099466 333 dbSNP
rs578027981 336 dbSNP
rs1228051821 339 dbSNP
rs1195686530 342 dbSNP
rs1340846143 345 dbSNP
rs543869587 351 dbSNP
rs1247787091 361 dbSNP
rs1331302078 362 dbSNP
rs1283420694 365 dbSNP
rs1445509898 366 dbSNP
rs1216635410 373 dbSNP
rs986176305 382 dbSNP
rs1329461563 385 dbSNP
rs557384181 400 dbSNP
rs1390709091 403 dbSNP
rs1368814543 411 dbSNP
rs1165522915 413 dbSNP
rs1487496962 414 dbSNP
rs193287417 416 dbSNP
rs1161885509 417 dbSNP
rs944674026 424 dbSNP
rs1471366890 425 dbSNP
rs976058931 438 dbSNP
rs1181751090 439 dbSNP
rs759229261 443 dbSNP
rs1482349753 448 dbSNP
rs138470036 450 dbSNP
rs1224068625 458 dbSNP
rs1472037315 462 dbSNP
rs1179595882 464 dbSNP
rs149626944 470 dbSNP
rs1352611639 475 dbSNP
rs929588299 484 dbSNP
rs1279868451 487 dbSNP
rs1060168 495 dbSNP
rs1409186030 500 dbSNP
rs184963414 504 dbSNP
rs541959453 511 dbSNP
rs1405612956 512 dbSNP
rs1349310543 524 dbSNP
rs887936156 529 dbSNP
rs1409241711 533 dbSNP
rs1158324734 539 dbSNP
rs1044163159 542 dbSNP
rs1432067346 547 dbSNP
rs1200709146 552 dbSNP
rs1163531043 563 dbSNP
rs1368342632 566 dbSNP
rs906960608 574 dbSNP
rs1490371791 576 dbSNP
rs1456847129 580 dbSNP
rs1002515311 589 dbSNP
rs1448348298 590 dbSNP
rs767322839 593 dbSNP
rs867900104 602 dbSNP
rs1031347486 610 dbSNP
rs1306370280 643 dbSNP
rs1223968387 648 dbSNP
rs1367030204 655 dbSNP
rs189346901 657 dbSNP
rs755797974 665 dbSNP
rs1320374264 678 dbSNP
rs953871260 682 dbSNP
rs1060171 685 dbSNP
rs985267237 693 dbSNP
rs1177827754 697 dbSNP
rs1480367997 698 dbSNP
rs1423915726 699 dbSNP
rs1188916562 715 dbSNP
rs1312107987 716 dbSNP
rs375436901 723 dbSNP
rs1242322968 727 dbSNP
rs34621455 727 dbSNP
rs564859396 733 dbSNP
rs1246939166 746 dbSNP
rs1264725113 748 dbSNP
rs1292168690 753 dbSNP
rs34392165 753 dbSNP
rs1311506361 756 dbSNP
rs966118942 770 dbSNP
rs1216393128 772 dbSNP
rs1362683161 773 dbSNP
rs180885116 775 dbSNP
rs1297147585 785 dbSNP
rs1433118760 786 dbSNP
rs1385464653 796 dbSNP
rs1202843874 798 dbSNP
rs1253508775 802 dbSNP
rs550206952 809 dbSNP
rs976026331 816 dbSNP
rs919252723 833 dbSNP
rs1390180633 844 dbSNP
rs1187568596 848 dbSNP
rs1480763274 860 dbSNP
rs929324026 868 dbSNP
rs1244791762 870 dbSNP
rs1180705843 881 dbSNP
rs1183970183 882 dbSNP
rs1253504489 884 dbSNP
rs369709648 888 dbSNP
rs1254192332 890 dbSNP
rs144340014 894 dbSNP
rs1802930 896 dbSNP
rs1165998636 897 dbSNP
rs1386456493 899 dbSNP
rs1429502667 905 dbSNP
rs1361820858 908 dbSNP
rs1316252915 909 dbSNP
rs948833792 910 dbSNP
rs753444444 929 dbSNP
rs1300420583 930 dbSNP
rs1443507588 935 dbSNP
rs1802931 942 dbSNP
rs553929612 943 dbSNP
rs1044600524 953 dbSNP
rs1167386234 955 dbSNP
rs752157321 956 dbSNP
rs1386697426 959 dbSNP
rs906921260 969 dbSNP
rs938396842 970 dbSNP
rs756806238 976 dbSNP
rs546504763 981 dbSNP
rs1053301009 987 dbSNP
rs17038587 1004 dbSNP
rs1251226041 1015 dbSNP
rs557368269 1022 dbSNP
rs1454694024 1023 dbSNP
rs1292795306 1033 dbSNP
rs1021506771 1035 dbSNP
rs538482739 1036 dbSNP
rs185144332 1038 dbSNP
rs1309537021 1040 dbSNP
rs1224869398 1043 dbSNP
rs779601831 1045 dbSNP
rs1006655493 1047 dbSNP
rs1019420249 1054 dbSNP
rs1225831367 1076 dbSNP
rs965213355 1082 dbSNP
rs1293785624 1093 dbSNP
rs571692898 1097 dbSNP
rs1457053968 1108 dbSNP
rs997592699 1109 dbSNP
rs373245753 1112 dbSNP
rs746405272 1127 dbSNP
rs1160979035 1129 dbSNP
rs1472915716 1133 dbSNP
rs1411128370 1135 dbSNP
rs1179849332 1141 dbSNP
rs1209018747 1143 dbSNP
rs758921582 1144 dbSNP
rs1253934157 1150 dbSNP
rs1209489013 1168 dbSNP
rs950741912 1170 dbSNP
rs1368508754 1173 dbSNP
rs375996648 1178 dbSNP
rs1216943145 1199 dbSNP
rs1328847260 1202 dbSNP
rs1287009359 1206 dbSNP
rs1060223 1231 dbSNP
rs909425644 1232 dbSNP
rs1346873063 1237 dbSNP
rs865859799 1238 dbSNP
rs1449406359 1241 dbSNP
rs1186989966 1244 dbSNP
rs1301334542 1250 dbSNP
rs781110294 1250 dbSNP
rs1385912008 1251 dbSNP
rs141585194 1255 dbSNP
rs1388128117 1256 dbSNP
rs1422131161 1257 dbSNP
rs190014254 1268 dbSNP
rs780478319 1270 dbSNP
rs1457584093 1274 dbSNP
rs1175599279 1277 dbSNP
rs564446897 1278 dbSNP
rs747267575 1287 dbSNP
rs980377305 1290 dbSNP
rs1198247329 1291 dbSNP
rs377327721 1300 dbSNP
rs1431723398 1307 dbSNP
rs181275772 1308 dbSNP
rs938868225 1312 dbSNP
rs1464754376 1315 dbSNP
rs1337487159 1321 dbSNP
rs1364288644 1323 dbSNP
rs1206177324 1325 dbSNP
rs1346291161 1326 dbSNP
rs1256144793 1330 dbSNP
rs1052865381 1339 dbSNP
rs572578964 1341 dbSNP
rs1238 1344 dbSNP
rs1218472426 1349 dbSNP
rs748304730 1364 dbSNP
rs1325311363 1370 dbSNP
rs11550186 1374 dbSNP
rs11550187 1378 dbSNP
rs889672428 1392 dbSNP
rs1006750125 1393 dbSNP
rs1402810480 1399 dbSNP
rs1171876200 1401 dbSNP
rs1464615976 1409 dbSNP
rs1040964063 1411 dbSNP
rs1374828507 1417 dbSNP
rs1449066334 1417 dbSNP
rs901012482 1417 dbSNP
rs35252221 1419 dbSNP
rs150502755 1433 dbSNP
rs1203677660 1436 dbSNP
rs1266939685 1445 dbSNP
rs1443556337 1446 dbSNP
rs12561953 1449 dbSNP
rs1207412941 1450 dbSNP
rs994444120 1457 dbSNP
rs1276090154 1461 dbSNP
rs1228743102 1464 dbSNP
rs1340979031 1467 dbSNP
rs1244380355 1474 dbSNP
rs1475928107 1476 dbSNP
rs1026366363 1477 dbSNP
rs1191038644 1481 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucuggggAGGAGGUAGg 5'
                 | ||||||| 
Target 5' --ucaagUACUCCAUCc 3'
 		1 - 15
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000263168.3 | 3UTR | UCAAGUACUCCAUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
141 hsa-miR-4534 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT087131 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT179641 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT243304 SLC25A36 solute carrier family 25 member 36 2 2
MIRT325574 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT448776 GNA13 G protein subunit alpha 13 2 2
MIRT451456 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT452150 PPP2R1B protein phosphatase 2 scaffold subunit Abeta 2 2
MIRT454199 HLA-A major histocompatibility complex, class I, A 2 2
MIRT455984 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT456058 SLC25A28 solute carrier family 25 member 28 2 2
MIRT457082 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT457278 ALDH9A1 aldehyde dehydrogenase 9 family member A1 2 2
MIRT457361 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT457396 CAMK2A calcium/calmodulin dependent protein kinase II alpha 2 2
MIRT458817 ZNF843 zinc finger protein 843 2 2
MIRT459697 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460346 ARL14EP ADP ribosylation factor like GTPase 14 effector protein 2 2
MIRT462713 MAPK13 mitogen-activated protein kinase 13 2 2
MIRT464278 VASH1 vasohibin 1 2 2
MIRT465634 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT465772 TMOD3 tropomodulin 3 2 2
MIRT466414 TFDP1 transcription factor Dp-1 2 2
MIRT467122 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 8
MIRT467475 SMYD1 SET and MYND domain containing 1 2 4
MIRT468462 SET SET nuclear proto-oncogene 2 2
MIRT468618 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT468835 RRM2 ribonucleotide reductase regulatory subunit M2 2 4
MIRT470890 PLXND1 plexin D1 2 2
MIRT473226 SMCR7L mitochondrial elongation factor 1 2 4
MIRT473858 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474975 KCND3 potassium voltage-gated channel subfamily D member 3 2 2
MIRT475858 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT478569 CTNND1 catenin delta 1 2 2
MIRT479347 CEP97 centrosomal protein 97 2 2
MIRT479910 CCDC117 coiled-coil domain containing 117 2 4
MIRT480122 CALR calreticulin 2 2
MIRT480892 BCL9L B-cell CLL/lymphoma 9 like 2 2
MIRT481149 AVL9 AVL9 cell migration associated 2 6
MIRT481527 ARL5B ADP ribosylation factor like GTPase 5B 2 10
MIRT481896 ANKRD40 ankyrin repeat domain 40 2 2
MIRT490138 FN3K fructosamine 3 kinase 2 4
MIRT490329 ANK1 ankyrin 1 2 4
MIRT491472 TMEM214 transmembrane protein 214 2 2
MIRT503552 TIGIT T-cell immunoreceptor with Ig and ITIM domains 2 4
MIRT504413 TUBA1B tubulin alpha 1b 2 4
MIRT508207 SLC35E1 solute carrier family 35 member E1 2 2
MIRT508333 SLC37A4 solute carrier family 37 member 4 2 6
MIRT516381 TRAF3IP2 TRAF3 interacting protein 2 2 4
MIRT518549 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT522545 MED28 mediator complex subunit 28 2 6
MIRT522592 MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1 like 2 2
MIRT522923 KAT6A lysine acetyltransferase 6A 2 4
MIRT525937 C11orf74 chromosome 11 open reading frame 74 2 2
MIRT527021 PABPN1L poly(A) binding protein nuclear 1 like, cytoplasmic 2 2
MIRT530396 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT530660 TRIM56 tripartite motif containing 56 2 2
MIRT531625 TM4SF5 transmembrane 4 L six family member 5 2 4
MIRT532703 TCN2 transcobalamin 2 2 4
MIRT540173 MB21D1 Mab-21 domain containing 1 2 2
MIRT540756 UTP6 UTP6, small subunit processome component 2 2
MIRT541966 ZNF485 zinc finger protein 485 2 2
MIRT542738 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT543090 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT550687 YARS tyrosyl-tRNA synthetase 2 2
MIRT553466 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT559980 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT561084 LLPH LLP homolog, long-term synaptic facilitation 2 2
MIRT561738 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT569872 KLK10 kallikrein related peptidase 10 2 2
MIRT570264 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT573431 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT573874 PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 2 2
MIRT576905 Poteg POTE ankyrin domain family, member G 2 2
MIRT607934 ANG angiogenin 2 2
MIRT609472 RPL7L1 ribosomal protein L7 like 1 2 4
MIRT612179 EMC3 ER membrane protein complex subunit 3 2 2
MIRT613428 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613746 GPR155 G protein-coupled receptor 155 2 2
MIRT615034 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT615565 JPH2 junctophilin 2 2 2
MIRT615937 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT616643 LRAT lecithin retinol acyltransferase 2 4
MIRT630890 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636542 FAM126B family with sequence similarity 126 member B 2 2
MIRT641392 NUBPL nucleotide binding protein like 2 2
MIRT641410 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT643184 HYPK huntingtin interacting protein K 2 2
MIRT652600 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT653974 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT655692 NUDT3 nudix hydrolase 3 2 2
MIRT660734 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 4
MIRT661604 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT663284 ZNF675 zinc finger protein 675 2 2
MIRT666337 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT666636 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT667125 OCIAD2 OCIA domain containing 2 2 2
MIRT670412 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671119 ZNF573 zinc finger protein 573 2 2
MIRT671152 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671336 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671867 ZNF429 zinc finger protein 429 2 2
MIRT671972 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672062 KIAA0930 KIAA0930 2 2
MIRT672652 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672671 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672768 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672927 LRRC2 leucine rich repeat containing 2 2 2
MIRT673156 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673270 RUNDC1 RUN domain containing 1 2 2
MIRT673329 THAP1 THAP domain containing 1 2 2
MIRT673348 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673664 ZNF440 zinc finger protein 440 2 2
MIRT673901 DCTN6 dynactin subunit 6 2 2
MIRT674399 MYCBP MYC binding protein 2 2
MIRT674523 PRR23A proline rich 23A 2 2
MIRT674831 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675064 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675078 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675123 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679399 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT686608 TMEM70 transmembrane protein 70 2 2
MIRT690371 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT694464 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT695706 OLA1 Obg like ATPase 1 2 2
MIRT696846 WDR13 WD repeat domain 13 2 2
MIRT700894 PER2 period circadian clock 2 2 2
MIRT701924 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT704918 CCDC36 coiled-coil domain containing 36 2 2
MIRT706211 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706546 GJD2 gap junction protein delta 2 2 2
MIRT706727 RFK riboflavin kinase 2 2
MIRT707366 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT707416 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710646 GLUL glutamate-ammonia ligase 2 2
MIRT712298 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713709 HIST3H2BB histone cluster 3 H2B family member b 2 2
MIRT713751 SLC9A8 solute carrier family 9 member A8 2 2
MIRT716423 VPS53 VPS53, GARP complex subunit 2 2
MIRT717169 UCHL3 ubiquitin C-terminal hydrolase L3 2 2
MIRT718877 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT720096 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4534 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4534 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4534 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4534 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4534 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4534 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-mir-4534 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4534 Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-4534 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4534 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4534 Platinum 23939 resistant tissue
hsa-miR-4534 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4534 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)

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