miRTarBase - #MIRT181263


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pre-miRNA Information
pre-miRNA hsa-mir-548ap   
Genomic Coordinates chr15: 85825635 - 85825730
Description Homo sapiens miR-548ap stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548ap-3p
Sequence 58| AAAAACCACAAUUACUUUU |76
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 15 + 85825699 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1391959840 4 dbSNP
rs1164149363 6 dbSNP
rs150751643 7 dbSNP
rs1414633461 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ASH1L   
Synonyms ASH1, ASH1L1, KMT2H
Description ASH1 like histone lysine methyltransferase
Transcript NM_018489   
Expression
Putative miRNA Targets on ASH1L
3'UTR of ASH1L
(miRNA target sites are highlighted)		 
>ASH1L|NM_018489|3'UTR
   1 CCCTCAAAGAATGAGAACCTCAAGCATCTGGGATCCAGTGGAGCTAATCAGTCCTGCCTCCTGCTCTCTGGGTATAGACA
  81 GGGGTGGGAAGGGTCCATCTGGGCAAGGGGAATGGGGCCATGTTGTTGACATTAGGTACTTAATAAGCCTTGGAGCTAGT
 161 GGAGAGGGAGAGGAAAGGGTTCTGTCCAAGACAGTTCAGGTTAATTAATTTTCTTCTCCATTGCTTCACCTTAAGGGTTA
 241 ATAATGTAGAGAGGAGGGAGGACCACATTGATGACCAGAACCTACTGGTACTTTATAGCATTTGCCCCACCCCACAGCTT
 321 AGGTTTTTCTGTCATCCTCAGATCCCACAGGCATTGCGAAGAAGCTGCTTCCTATACCCAGGTATAACTCAAAATCCAAA
 401 GGGATAGGGCCAGGATCCCTATTCCTACCCCATCTATTCTCTGTTGGCTCCAAGAGCTACCCCAGAGACCTTAAACAGAA
 481 ACAGTAGCTGAGGCTTCTTCCTAGATACCTGACTAGGGAAGTTTGTCTCTCCTTTCTTGCCCAACCAGGTCAAAGTAAAA
 561 TGTGAGTTGACAGCTCAAAGCACTTGTAACTGCTGCCCCCTCCCTACCTCTACTCCCCAAAATGGAATCATGGGATAGGG
 641 AAGGCCCCCATGGGGTCAGAAGGGCACGGTAGTTCTTGCAATTATTTTTGTTTTACCCTTCATAACCTGTCAAACATATT
 721 TTTTTCTAATGAGAAAGCCAGGCCCCCGCCAGCACACATGCTGTTTTTAATGCGCTGTAGTTCTTGTGTGTCTGCTGTGC
 801 TGTGCAAATGGAGATTCAGTTCAAAATAAAATCATTTAAAAACCTACATAAAAAGAACTCTAAACCCACCCCTGCAACAA
 881 AAGTCACTACATAAACTGTTCAGCAGTATTCACCTATCAGAGTATTTGTTGTGAGTATAGATTATCAATTGAAAACACTA
 961 CTCTTGTTTTCTTAATTGTACAGTTTTCAATGTCCCTTTCTTAAAGAGACAGTATATTTCTCTTCACCCCTAGCCCATCT
1041 TCCCTCACCCTCCTGAATGACATCAGGAGGTATATCCAGGGTGTCTCCTTCCTTCCTACTCTCTTGACCAGAAGTTAACA
1121 GACTATACTGTCTCTTTAAAAATAAAATTTAAAAAGCTTTGTTGTCTTTTCAGACATACATATGCATATATGTTTTAGAT
1201 GTTCTTATAAGAGAAAAGATGGTTTTTAAATGTGCCAAGTTGTGTGTGTGTGTGTATATATATGTGTGTATGTGTGTGTA
1281 TATATATATGTGTGTGTGTATATATATACACACACACACACACACCTGCTGTGTGATTGGTAAGCAATACAATAGTAAAC
1361 ATGTCCCCATTACTTTTTTCTAATATTGGACCAATGCTGTCCTAATTGTACATTTCCCCTTATGGTGACGATGCTCTGAC
1441 TCGTTTAGGTAGACACATTGACCACCTTCCATTCCATTAAATATTTTTTCCTTTTTCCCCTTTCTGTGTCATTCTTGAGG
1521 AAAAAACAAAAGAGAGAGGGGATGCCAATGATCCCCTTGAGCAGAGAAAAAGCAAAATAAATATTTTATTAAAGAAAAAA
1601 GAGAATTAAGAAAATAGTTTGGAGTATTTTCTTACTGTAGAGAAGCACTGTACATTACTAAGAGACCTGGGTATAAGATA
1681 CTCACATGTGGAGCTGGAAAAATCGCATGTCCAAGCCCGTTTGAGTGGTTTCTTTTGTTTTTCATTGCAGGGAGTGGGTG
1761 GGAGGGAGGTGGGACTAGGGGCACTTTGGGGGTCTCCTTTTAGTCAAAAGCGAGAAAATGACAAGAAAGAGATTAAAATT
1841 CAATGTTTCCTTTATAGTGTTAAACACTAAAATTTTAAAAAAGATGAAAAAGAAAAAAAAACTTTGTAAAATGCGAGAAC
1921 AGAAGCAAAAGACACTACGCTCTGTCATTTTATCTTTCTTTTGTTGAAAGACTAAAAAAAAACTGAAATGTTTTTTAGAC
2001 AATCAAATGTTAGGTAAGTGCAAAAACTTGTTTTTTCTTACTGGTGTAGAAATTAATGCCTTTTTTTATTTTTCAGTTAT
2081 TTTATAATAACGAAATAAAAAGAACCCCCCAGCTGCCAGGCGGGTTTTGGTGTTTGAAATGCGGGGCAAAGCACTACATC
2161 ACTGCAAATAGATACAGAGTTAGTCTGCATGTCTGTAGGCTGTGTGATTGCGGAAAATATAAATGCTGCTAATATATTTC
2241 CTTTTTACAAAAGCATATCTAAATAGATGATTGTTTTGATGTTAATCTTTGTAAATTATGTATTACCAATTTTAACATTG
2321 GATGTAATTGCATACAAAGCTTGCATCTCAATCCTTGAAAGTCTAGTATTAAATGGAAAAAACTTTTCCTAACTGTGGAA
2401 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuUUCAUUAACACCAAAAa 5'
            :|| ||   ||||||| 
Target 5' aaGAGAAAAGATGGTTTTt 3'
 1209 - 1227 149.00 -6.90
2 
miRNA  3' uuuucAUUAACACCAAAaa 5'
               |:|  |||||||  
Target 5' ccgttTGA--GTGGTTTct 3'
 1717 - 1733 126.00 -7.00
3 
miRNA  3' uuuUCAUU--AACACCA--AAAa 5'
             || ||  |  ||||  ||| 
Target 5' accAG-AACCTACTGGTACTTTa 3'
 274 - 295 101.00 -5.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30185208 32 COSMIC
COSN30752756 37 COSMIC
COSN31490956 41 COSMIC
COSN30119709 92 COSMIC
COSN30124213 97 COSMIC
COSN31576121 120 COSMIC
COSN1089966 143 COSMIC
COSN31499155 164 COSMIC
COSN8643682 166 COSMIC
COSN31506112 172 COSMIC
COSN6003617 261 COSMIC
COSN20073822 272 COSMIC
COSN20090368 357 COSMIC
COSN1407271 450 COSMIC
COSN29044695 718 COSMIC
COSN17131980 740 COSMIC
COSN15662922 811 COSMIC
COSN22129613 819 COSMIC
COSN31527829 1076 COSMIC
COSN31609556 1149 COSMIC
COSN25569563 1174 COSMIC
COSN7178570 1179 COSMIC
COSN28021847 1241 COSMIC
COSN8643681 1254 COSMIC
COSN8643680 1262 COSMIC
COSN31521592 1278 COSMIC
COSN15659911 1288 COSMIC
COSN20095427 1288 COSMIC
COSN31518437 1290 COSMIC
COSN19662833 1300 COSMIC
COSN30175622 1307 COSMIC
COSN14603743 1309 COSMIC
COSN31542779 1442 COSMIC
COSN31536758 1497 COSMIC
COSN31548794 1514 COSMIC
COSN16703138 1532 COSMIC
COSN23506257 1594 COSMIC
COSN30540295 1704 COSMIC
COSN31524074 1727 COSMIC
COSN28213934 1812 COSMIC
COSN31514962 1892 COSMIC
COSN31524077 1901 COSMIC
COSN31530704 1908 COSMIC
COSN28754148 1917 COSMIC
COSN31516858 1958 COSMIC
COSN31539128 1973 COSMIC
COSN31545554 2049 COSMIC
COSN22722599 2171 COSMIC
COSN31523607 2305 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1476468090 3 dbSNP
rs1240430685 22 dbSNP
rs761619556 24 dbSNP
rs1159031960 28 dbSNP
rs1452428099 31 dbSNP
rs563184433 36 dbSNP
rs768382171 46 dbSNP
rs202077056 49 dbSNP
rs775191382 50 dbSNP
rs746467518 56 dbSNP
rs749244880 63 dbSNP
rs1344366211 66 dbSNP
rs945693447 80 dbSNP
rs545754333 81 dbSNP
rs1314144826 82 dbSNP
rs1279678819 84 dbSNP
rs1219007137 86 dbSNP
rs1343323657 92 dbSNP
rs1423689753 102 dbSNP
rs912901680 110 dbSNP
rs572437041 115 dbSNP
rs1401163197 116 dbSNP
rs180864404 117 dbSNP
rs1450789727 120 dbSNP
rs1168900187 123 dbSNP
rs1297002822 130 dbSNP
rs542063669 135 dbSNP
rs1360522468 181 dbSNP
rs373381447 183 dbSNP
rs772590267 186 dbSNP
rs189369643 188 dbSNP
rs1402852686 190 dbSNP
rs1028826024 197 dbSNP
rs1334598553 221 dbSNP
rs556439213 229 dbSNP
rs1367508321 231 dbSNP
rs183992354 237 dbSNP
rs570423308 241 dbSNP
rs1229154492 249 dbSNP
rs1478090394 251 dbSNP
rs558620217 255 dbSNP
rs1305945179 266 dbSNP
rs748569363 268 dbSNP
rs975007589 275 dbSNP
rs533749529 276 dbSNP
rs964113735 281 dbSNP
rs779607903 283 dbSNP
rs1008333130 289 dbSNP
rs887065905 291 dbSNP
rs1465872910 294 dbSNP
rs575807974 307 dbSNP
rs931963094 312 dbSNP
rs769126222 338 dbSNP
rs1260425890 357 dbSNP
rs566820192 358 dbSNP
rs1469086021 366 dbSNP
rs1334619819 372 dbSNP
rs1386018665 385 dbSNP
rs941285868 389 dbSNP
rs908482238 392 dbSNP
rs983003036 397 dbSNP
rs1317820333 399 dbSNP
rs898781254 401 dbSNP
rs1388787087 406 dbSNP
rs1212291399 410 dbSNP
rs1302241538 410 dbSNP
rs1380714286 413 dbSNP
rs1270585953 415 dbSNP
rs1215917501 421 dbSNP
rs181319638 423 dbSNP
rs559224286 428 dbSNP
rs1403498069 436 dbSNP
rs916988313 441 dbSNP
rs1479988300 442 dbSNP
rs1001685380 443 dbSNP
rs1173939092 444 dbSNP
rs991206255 463 dbSNP
rs958327508 467 dbSNP
rs1457748219 469 dbSNP
rs529908812 469 dbSNP
rs569039641 471 dbSNP
rs1343581191 477 dbSNP
rs550477602 484 dbSNP
rs1294357501 497 dbSNP
rs531846038 499 dbSNP
rs564405291 500 dbSNP
rs1403528368 507 dbSNP
rs1020560892 509 dbSNP
rs1009480586 526 dbSNP
rs1425576519 548 dbSNP
rs545819812 552 dbSNP
rs527674660 557 dbSNP
rs1054571097 561 dbSNP
rs890663698 562 dbSNP
rs1223036923 565 dbSNP
rs1292090713 568 dbSNP
rs1050468349 579 dbSNP
rs560451655 582 dbSNP
rs1240311013 583 dbSNP
rs1253754783 596 dbSNP
rs1470388939 598 dbSNP
rs539213240 599 dbSNP
rs974702335 600 dbSNP
rs1407158961 602 dbSNP
rs756308499 612 dbSNP
rs1164254463 616 dbSNP
rs1365215044 618 dbSNP
rs542125166 619 dbSNP
rs776313781 619 dbSNP
rs188950407 620 dbSNP
rs374348958 622 dbSNP
rs908452309 634 dbSNP
rs1047008111 638 dbSNP
rs1229559039 640 dbSNP
rs150741070 644 dbSNP
rs1025640472 647 dbSNP
rs949887771 651 dbSNP
rs917082969 652 dbSNP
rs1358064098 656 dbSNP
rs1312769427 657 dbSNP
rs544463843 667 dbSNP
rs114217111 668 dbSNP
rs1203472833 672 dbSNP
rs937106144 679 dbSNP
rs750470549 681 dbSNP
rs1447164577 684 dbSNP
rs1001745606 690 dbSNP
rs1442855034 692 dbSNP
rs184441330 697 dbSNP
rs907346948 706 dbSNP
rs1045911719 716 dbSNP
rs1375900903 717 dbSNP
rs866151725 730 dbSNP
rs1361238520 748 dbSNP
rs533813824 748 dbSNP
rs1449451337 757 dbSNP
rs1336645119 758 dbSNP
rs891565609 767 dbSNP
rs1381480915 773 dbSNP
rs781161813 774 dbSNP
rs1213802285 787 dbSNP
rs771895703 792 dbSNP
rs1443901113 811 dbSNP
rs935638976 817 dbSNP
rs1204304086 818 dbSNP
rs921631384 827 dbSNP
rs1038928790 848 dbSNP
rs954834286 849 dbSNP
rs1190542549 853 dbSNP
rs1373877013 855 dbSNP
rs1475236460 859 dbSNP
rs1166338693 860 dbSNP
rs373212416 865 dbSNP
rs911717880 870 dbSNP
rs1470498965 886 dbSNP
rs1176355006 891 dbSNP
rs1422882560 898 dbSNP
rs1382396548 903 dbSNP
rs1404460354 906 dbSNP
rs1449872805 913 dbSNP
rs1179501359 921 dbSNP
rs1326486456 924 dbSNP
rs996373040 928 dbSNP
rs1268043833 932 dbSNP
rs1346934761 933 dbSNP
rs1223822470 935 dbSNP
rs1262461187 936 dbSNP
rs1321270758 937 dbSNP
rs983322107 943 dbSNP
rs1210488828 945 dbSNP
rs1262564701 951 dbSNP
rs1248903282 957 dbSNP
rs1446495264 959 dbSNP
rs1248615852 960 dbSNP
rs192967669 972 dbSNP
rs951477387 976 dbSNP
rs1480972149 981 dbSNP
rs899228162 990 dbSNP
rs141175258 991 dbSNP
rs1489081627 992 dbSNP
rs1159625757 1000 dbSNP
rs41264229 1011 dbSNP
rs1399605902 1025 dbSNP
rs1315787903 1027 dbSNP
rs1221090949 1028 dbSNP
rs962995474 1030 dbSNP
rs1282448498 1039 dbSNP
rs1034363798 1042 dbSNP
rs1047382437 1044 dbSNP
rs1261225086 1049 dbSNP
rs1350062052 1050 dbSNP
rs1287652367 1065 dbSNP
rs1203399125 1068 dbSNP
rs949989856 1071 dbSNP
rs1240456554 1076 dbSNP
rs1316072083 1077 dbSNP
rs1304555516 1087 dbSNP
rs536573244 1092 dbSNP
rs1267266967 1095 dbSNP
rs1473776682 1098 dbSNP
rs1183243770 1116 dbSNP
rs1055540548 1138 dbSNP
rs1469207504 1156 dbSNP
rs1368196411 1157 dbSNP
rs1477822376 1166 dbSNP
rs1156249619 1174 dbSNP
rs937199497 1175 dbSNP
rs1001734250 1179 dbSNP
rs971661648 1183 dbSNP
rs1403108024 1184 dbSNP
rs1302141448 1190 dbSNP
rs1024411810 1191 dbSNP
rs1392856984 1201 dbSNP
rs1010392652 1211 dbSNP
rs749320243 1213 dbSNP
rs528864992 1216 dbSNP
rs1317312165 1221 dbSNP
rs1362329624 1222 dbSNP
rs1360222945 1234 dbSNP
rs1222119059 1235 dbSNP
rs765775951 1245 dbSNP
rs576341576 1248 dbSNP
rs41264227 1254 dbSNP
rs114130331 1256 dbSNP
rs1196704501 1256 dbSNP
rs1436624510 1256 dbSNP
rs541142167 1256 dbSNP
rs562925292 1262 dbSNP
rs1267198918 1264 dbSNP
rs1444701515 1264 dbSNP
rs999950107 1264 dbSNP
rs900132084 1269 dbSNP
rs1197909936 1270 dbSNP
rs1298485055 1270 dbSNP
rs1463362041 1270 dbSNP
rs1389645208 1272 dbSNP
rs954926858 1272 dbSNP
rs1338622387 1274 dbSNP
rs1038750623 1278 dbSNP
rs944600844 1280 dbSNP
rs1313198899 1282 dbSNP
rs867428730 1286 dbSNP
rs1228394318 1287 dbSNP
rs867259271 1288 dbSNP
rs113407669 1289 dbSNP
rs1337848426 1289 dbSNP
rs1244227732 1290 dbSNP
rs974902414 1290 dbSNP
rs1182401293 1292 dbSNP
rs1216750697 1293 dbSNP
rs1349470949 1294 dbSNP
rs1240911283 1298 dbSNP
rs146183224 1300 dbSNP
rs148726843 1300 dbSNP
rs1364129587 1302 dbSNP
rs141035761 1302 dbSNP
rs1295107969 1304 dbSNP
rs963572719 1305 dbSNP
rs532188574 1307 dbSNP
rs116477839 1309 dbSNP
rs1264338094 1309 dbSNP
rs114319471 1311 dbSNP
rs1253780803 1315 dbSNP
rs1016727835 1317 dbSNP
rs1186806495 1321 dbSNP
rs185736856 1324 dbSNP
rs1276908108 1326 dbSNP
rs748191461 1326 dbSNP
rs755012729 1326 dbSNP
rs1004970953 1334 dbSNP
rs1282494271 1357 dbSNP
rs1201270365 1361 dbSNP
rs927296197 1365 dbSNP
rs980098096 1374 dbSNP
rs1429702266 1379 dbSNP
rs1469261653 1382 dbSNP
rs1221633971 1385 dbSNP
rs116580423 1387 dbSNP
rs1347093863 1400 dbSNP
rs1298863613 1406 dbSNP
rs1454321358 1411 dbSNP
rs1024485455 1416 dbSNP
rs1024989459 1419 dbSNP
rs759259479 1423 dbSNP
rs552245373 1429 dbSNP
rs148609149 1430 dbSNP
rs1309774111 1431 dbSNP
rs77675900 1442 dbSNP
rs1001317722 1443 dbSNP
rs1259820752 1444 dbSNP
rs1377449505 1446 dbSNP
rs1224208033 1447 dbSNP
rs1269414808 1449 dbSNP
rs1479978539 1464 dbSNP
rs1189412066 1467 dbSNP
rs1409985263 1476 dbSNP
rs1419779192 1481 dbSNP
rs1174858806 1482 dbSNP
rs1479069058 1490 dbSNP
rs541830197 1492 dbSNP
rs1343487540 1499 dbSNP
rs1043161540 1504 dbSNP
rs1303979696 1505 dbSNP
rs1000343376 1510 dbSNP
rs114579766 1523 dbSNP
rs1374644521 1534 dbSNP
rs1223879503 1539 dbSNP
rs1259145764 1542 dbSNP
rs1305717942 1545 dbSNP
rs765966649 1546 dbSNP
rs563018264 1548 dbSNP
rs544836032 1555 dbSNP
rs1291975094 1567 dbSNP
rs1219060498 1572 dbSNP
rs71845643 1572 dbSNP
rs537465700 1573 dbSNP
rs890139077 1580 dbSNP
rs1480947451 1598 dbSNP
rs1176520613 1602 dbSNP
rs1047654757 1603 dbSNP
rs540520123 1603 dbSNP
rs1278842984 1605 dbSNP
rs1384773181 1609 dbSNP
rs752150139 1610 dbSNP
rs192524983 1649 dbSNP
rs975000221 1655 dbSNP
rs963498880 1658 dbSNP
rs571425788 1660 dbSNP
rs868578049 1666 dbSNP
rs983914084 1667 dbSNP
rs1324778266 1670 dbSNP
rs950818001 1673 dbSNP
rs1358224686 1677 dbSNP
rs898985828 1678 dbSNP
rs1037580334 1679 dbSNP
rs941424810 1692 dbSNP
rs1396862988 1704 dbSNP
rs565437200 1705 dbSNP
rs1203804969 1710 dbSNP
rs540331849 1715 dbSNP
rs1462715458 1718 dbSNP
rs1034198300 1719 dbSNP
rs959402212 1719 dbSNP
rs1467563195 1721 dbSNP
rs772954796 1729 dbSNP
rs376985314 1730 dbSNP
rs1169864072 1737 dbSNP
rs1401652973 1748 dbSNP
rs1420735881 1757 dbSNP
rs1170596074 1763 dbSNP
rs1409688371 1769 dbSNP
rs1169167696 1771 dbSNP
rs1408886948 1772 dbSNP
rs1047304 1774 dbSNP
rs1381364250 1776 dbSNP
rs1474761077 1780 dbSNP
rs554618295 1796 dbSNP
rs1001410529 1799 dbSNP
rs950033817 1805 dbSNP
rs917253597 1811 dbSNP
rs989432344 1812 dbSNP
rs1010507691 1828 dbSNP
rs1204201338 1829 dbSNP
rs1242212118 1829 dbSNP
rs891539043 1831 dbSNP
rs1051544340 1833 dbSNP
rs1195613361 1834 dbSNP
rs1242848392 1838 dbSNP
rs535858205 1857 dbSNP
rs1458931803 1859 dbSNP
rs1033591000 1876 dbSNP
rs575525964 1877 dbSNP
rs932938086 1879 dbSNP
rs1258570645 1883 dbSNP
rs1195184190 1885 dbSNP
rs1337489351 1886 dbSNP
rs1267273070 1892 dbSNP
rs1470611824 1896 dbSNP
rs1039278509 1902 dbSNP
rs1176331158 1902 dbSNP
rs1400941411 1902 dbSNP
rs921600479 1902 dbSNP
rs942308811 1903 dbSNP
rs909484678 1906 dbSNP
rs1245672030 1914 dbSNP
rs556974313 1921 dbSNP
rs771455894 1938 dbSNP
rs1017336324 1939 dbSNP
rs1206929465 1941 dbSNP
rs1285243959 1944 dbSNP
rs770712995 1954 dbSNP
rs1449372738 1955 dbSNP
rs1214686414 1962 dbSNP
rs748220904 1965 dbSNP
rs1378125864 1972 dbSNP
rs1328712838 1973 dbSNP
rs577959889 1974 dbSNP
rs992213474 1974 dbSNP
rs1033661590 1983 dbSNP
rs761441228 1983 dbSNP
rs959329288 1983 dbSNP
rs1385028734 1986 dbSNP
rs879505011 1990 dbSNP
rs111566986 1995 dbSNP
rs968643920 1997 dbSNP
rs954326885 2014 dbSNP
rs1424821419 2020 dbSNP
rs1384151068 2021 dbSNP
rs1405256499 2027 dbSNP
rs1322844644 2028 dbSNP
rs752199724 2037 dbSNP
rs1329224679 2039 dbSNP
rs551684330 2043 dbSNP
rs186687102 2053 dbSNP
rs1350039107 2055 dbSNP
rs1026019228 2059 dbSNP
rs1441266908 2060 dbSNP
rs1238598263 2067 dbSNP
rs1180876950 2068 dbSNP
rs1222165544 2068 dbSNP
rs1440108475 2068 dbSNP
rs1435990254 2074 dbSNP
rs1269442139 2075 dbSNP
rs774992111 2078 dbSNP
rs746678006 2089 dbSNP
rs182414333 2090 dbSNP
rs769293721 2091 dbSNP
rs1289787000 2105 dbSNP
rs1386660447 2107 dbSNP
rs1162483207 2111 dbSNP
rs997284526 2111 dbSNP
rs900139595 2115 dbSNP
rs1037927618 2121 dbSNP
rs1329440944 2122 dbSNP
rs1376271416 2124 dbSNP
rs1002016770 2132 dbSNP
rs1444573095 2137 dbSNP
rs1317471810 2142 dbSNP
rs528257452 2142 dbSNP
rs1244309638 2143 dbSNP
rs1264097903 2147 dbSNP
rs1341911167 2147 dbSNP
rs11552268 2161 dbSNP
rs888034325 2175 dbSNP
rs773449798 2177 dbSNP
rs546343375 2179 dbSNP
rs1440539448 2180 dbSNP
rs1176194680 2183 dbSNP
rs1244414845 2192 dbSNP
rs1444916893 2201 dbSNP
rs1163619439 2203 dbSNP
rs534050517 2211 dbSNP
rs1366569586 2218 dbSNP
rs1048485162 2225 dbSNP
rs1168437627 2253 dbSNP
rs1324788836 2263 dbSNP
rs929459088 2270 dbSNP
rs1044422064 2273 dbSNP
rs1338823756 2279 dbSNP
rs950143131 2283 dbSNP
rs1383583434 2291 dbSNP
rs749609446 2306 dbSNP
rs559164769 2315 dbSNP
rs992182567 2318 dbSNP
rs934888769 2327 dbSNP
rs1161242428 2329 dbSNP
rs1421112018 2341 dbSNP
rs926253750 2347 dbSNP
rs979435264 2350 dbSNP
rs964850317 2353 dbSNP
rs1206101244 2366 dbSNP
rs1264522868 2373 dbSNP
rs1408332854 2383 dbSNP
rs6695298 2392 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuUUCAUUAACACCAAAAa 5'
            :|| ||   ||||||| 
Target 5' aaGAGAAAAGAUGGUUUUu 3'
 		1 - 19
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000368346.3 | 3UTR | AAGAGAAAAGAUGGUUUUUAAAUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
168 hsa-miR-548ap-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059371 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT072854 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 6
MIRT076951 PCGF2 polycomb group ring finger 2 2 6
MIRT083943 TFAP2C transcription factor AP-2 gamma 2 2
MIRT085407 ETS2 ETS proto-oncogene 2, transcription factor 2 2
MIRT109797 KLHL15 kelch like family member 15 2 2
MIRT114053 AKAP11 A-kinase anchoring protein 11 2 10
MIRT130205 TXNIP thioredoxin interacting protein 2 6
MIRT150038 MIDN midnolin 2 2
MIRT181263 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT205597 NCL nucleolin 2 2
MIRT222256 ACTB actin beta 2 4
MIRT245657 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT250952 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT252500 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT271995 ARF1 ADP ribosylation factor 1 2 4
MIRT280806 RNF11 ring finger protein 11 2 2
MIRT293808 FEM1A fem-1 homolog A 2 2
MIRT318235 RREB1 ras responsive element binding protein 1 2 2
MIRT341461 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT347424 CEBPG CCAAT/enhancer binding protein gamma 2 4
MIRT351865 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT357988 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT377096 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT407313 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT441565 LMOD3 leiomodin 3 2 2
MIRT442365 ZC3H12C zinc finger CCCH-type containing 12C 2 2
MIRT443229 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT443405 HMX3 H6 family homeobox 3 2 2
MIRT446056 NR5A2 nuclear receptor subfamily 5 group A member 2 2 2
MIRT448278 ZNF652 zinc finger protein 652 2 2
MIRT450823 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT453017 CCDC115 coiled-coil domain containing 115 2 17
MIRT454464 PPP2R2B protein phosphatase 2 regulatory subunit Bbeta 2 2
MIRT456361 CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 2 2
MIRT460008 DNALI1 dynein axonemal light intermediate chain 1 2 2
MIRT463155 ZNF385A zinc finger protein 385A 2 6
MIRT463767 YPEL2 yippee like 2 2 2
MIRT468311 SFT2D2 SFT2 domain containing 2 2 2
MIRT470669 POLR2D RNA polymerase II subunit D 2 4
MIRT478518 CTTN cortactin 2 2
MIRT480508 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT484719 INHBA inhibin beta A subunit 2 12
MIRT485495 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT487303 SLC38A9 solute carrier family 38 member 9 2 2
MIRT487772 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT491877 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT494305 CEP120 centrosomal protein 120 2 2
MIRT495397 TRIM24 tripartite motif containing 24 2 2
MIRT495647 CDK1 cyclin dependent kinase 1 2 2
MIRT496666 TMEM237 transmembrane protein 237 2 2
MIRT496838 ZNF460 zinc finger protein 460 2 2
MIRT498639 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT503929 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT506064 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT506583 MIER3 MIER family member 3 2 4
MIRT506607 MAT2A methionine adenosyltransferase 2A 2 4
MIRT506845 KIF23 kinesin family member 23 2 6
MIRT508537 RPP14 ribonuclease P/MRP subunit p14 2 4
MIRT509670 ZNF354B zinc finger protein 354B 2 10
MIRT511171 MBNL3 muscleblind like splicing regulator 3 2 6
MIRT512148 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT512832 ID4 inhibitor of DNA binding 4, HLH protein 2 6
MIRT514559 XRCC3 X-ray repair cross complementing 3 2 4
MIRT515857 AJAP1 adherens junctions associated protein 1 2 4
MIRT521849 PNISR PNN interacting serine and arginine rich protein 2 4
MIRT525365 SYNM synemin 2 2
MIRT527121 ARHGAP15 Rho GTPase activating protein 15 2 2
MIRT527272 FBLN2 fibulin 2 2 2
MIRT527440 COL4A3 collagen type IV alpha 3 chain 2 2
MIRT527659 CD300E CD300e molecule 2 2
MIRT528335 TBC1D22B TBC1 domain family member 22B 2 2
MIRT529035 EXOC8 exocyst complex component 8 2 2
MIRT529322 PDE5A phosphodiesterase 5A 2 2
MIRT529678 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT529847 SMTN smoothelin 2 2
MIRT530386 ZNF431 zinc finger protein 431 2 2
MIRT530914 GPR85 G protein-coupled receptor 85 2 2
MIRT531795 KDR kinase insert domain receptor 2 2
MIRT532247 KLF2 Kruppel like factor 2 2 4
MIRT532659 CBX7 chromobox 7 2 2
MIRT533632 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT534812 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT534976 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT536589 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT536780 HNRNPD heterogeneous nuclear ribonucleoprotein D 2 2
MIRT538765 CABLES1 Cdk5 and Abl enzyme substrate 1 2 2
MIRT539296 ANGEL2 angel homolog 2 2 2
MIRT539622 SHISA9 shisa family member 9 2 2
MIRT539652 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540348 OPHN1 oligophrenin 1 2 2
MIRT540414 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541397 CDC27 cell division cycle 27 2 2
MIRT542917 HSBP1 heat shock factor binding protein 1 2 2
MIRT544711 EIF5A eukaryotic translation initiation factor 5A 2 4
MIRT544999 MFF mitochondrial fission factor 2 4
MIRT553290 TSPAN3 tetraspanin 3 2 2
MIRT553456 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT553783 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT554657 ROBO1 roundabout guidance receptor 1 2 2
MIRT555105 PURB purine rich element binding protein B 2 2
MIRT557236 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT560862 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561544 SON SON DNA binding protein 2 2
MIRT561555 SLMO2 PRELI domain containing 3B 2 2
MIRT563765 ZNF678 zinc finger protein 678 2 2
MIRT565654 SIX4 SIX homeobox 4 2 2
MIRT568081 CELF2 CUGBP Elav-like family member 2 2 2
MIRT568760 MYBL1 MYB proto-oncogene like 1 2 2
MIRT569079 CADM2 cell adhesion molecule 2 2 2
MIRT569510 THYN1 thymocyte nuclear protein 1 2 2
MIRT571269 CDKN2AIP CDKN2A interacting protein 2 2
MIRT571810 PHF19 PHD finger protein 19 2 2
MIRT572555 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT573783 SLC24A4 solute carrier family 24 member 4 2 4
MIRT576442 Ccdc115 coiled-coil domain containing 115 2 10
MIRT576713 Slc30a3 solute carrier family 30 (zinc transporter), member 3 2 3
MIRT608378 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608485 NKTR natural killer cell triggering receptor 2 6
MIRT610187 FAM49A family with sequence similarity 49 member A 2 2
MIRT611632 EDIL3 EGF like repeats and discoidin domains 3 2 2
MIRT613535 TRA2B transformer 2 beta homolog 2 2
MIRT616222 PTPN11 protein tyrosine phosphatase, non-receptor type 11 2 2
MIRT622371 SALL1 spalt like transcription factor 1 2 2
MIRT624372 CDK12 cyclin dependent kinase 12 2 2
MIRT624996 ZNF665 zinc finger protein 665 2 4
MIRT626876 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT627738 RAP2B RAP2B, member of RAS oncogene family 2 4
MIRT628491 ADAT2 adenosine deaminase, tRNA specific 2 2 2
MIRT633648 PLEKHG7 pleckstrin homology and RhoGEF domain containing G7 2 4
MIRT634029 SLC30A3 solute carrier family 30 member 3 2 3
MIRT635924 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638288 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT641960 RNF115 ring finger protein 115 2 2
MIRT643574 CTNNA3 catenin alpha 3 2 2
MIRT645181 NOL9 nucleolar protein 9 2 4
MIRT647498 ZNF639 zinc finger protein 639 2 2
MIRT647683 PCK1 phosphoenolpyruvate carboxykinase 1 2 2
MIRT648423 MYOZ3 myozenin 3 2 2
MIRT650114 ZCCHC9 zinc finger CCHC-type containing 9 2 2
MIRT651077 ZNF518B zinc finger protein 518B 2 4
MIRT651416 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT651457 XKR4 XK related 4 2 2
MIRT653620 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653638 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654897 POU2F1 POU class 2 homeobox 1 2 2
MIRT656484 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT658017 GABRA4 gamma-aminobutyric acid type A receptor alpha4 subunit 2 2
MIRT658042 FZD10 frizzled class receptor 10 2 2
MIRT660094 BTBD3 BTB domain containing 3 2 2
MIRT663924 MAGEF1 MAGE family member F1 2 2
MIRT665883 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT669052 CEP128 centrosomal protein 128 2 2
MIRT669712 AAGAB alpha and gamma adaptin binding protein 2 2
MIRT686813 SNX2 sorting nexin 2 2 4
MIRT689884 SOD2 superoxide dismutase 2 2 2
MIRT693275 GLRX2 glutaredoxin 2 2 4
MIRT697057 BCAR1 BCAR1, Cas family scaffolding protein 2 2
MIRT703298 GID4 GID complex subunit 4 homolog 2 2
MIRT704088 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT707720 CDC6 cell division cycle 6 2 2
MIRT708137 GK5 glycerol kinase 5 (putative) 2 2
MIRT709213 KLHL30 kelch like family member 30 2 2
MIRT710063 RWDD2A RWD domain containing 2A 2 2
MIRT712771 POU6F2 POU class 6 homeobox 2 2 2
MIRT715074 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715388 TADA3 transcriptional adaptor 3 2 2
MIRT717713 NCKAP1 NCK associated protein 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-548ap Tripterygium wilfordii Hook F resistant tissue
hsa-miR-548ap-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-548ap-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-548ap-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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