miRTarBase - #MIRT183592


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pre-miRNA Information
pre-miRNA hsa-mir-4745   
Genomic Coordinates chr19: 804940 - 805001
Description Homo sapiens miR-4745 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4745-5p
Sequence 2| UGAGUGGGGCUCCCGGGACGGCG |24
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6231418 6 COSMIC
COSN9853232 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1383282684 5 dbSNP
rs1397680926 5 dbSNP
rs569478349 7 dbSNP
rs1370492118 8 dbSNP
rs773676198 9 dbSNP
rs1163342742 10 dbSNP
rs1364058972 13 dbSNP
rs374562787 14 dbSNP
rs771228280 15 dbSNP
rs10422347 19 dbSNP
rs759808148 20 dbSNP
rs765171167 21 dbSNP
rs147466582 22 dbSNP
rs139864698 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZC3H11A   
Synonyms ZC3HDC11A
Description zinc finger CCCH-type containing 11A
Transcript NM_014827   
Expression
Putative miRNA Targets on ZC3H11A
3'UTR of ZC3H11A
(miRNA target sites are highlighted)		 
>ZC3H11A|NM_014827|3'UTR
   1 AGGTGGTAGTGAGGACACTTTAAAAAAAAAATCGCCAAAAAACTGGACTTAGTTTCATCTATTGTAACATTTACCTGAGA
  81 TGATCATTTCTTTAGTCTAGAATTTGCCCCAAATCAGAAGTATACCTCTGAATTATCTGTATGTGTCCTGGATTCCTTGG
 161 GGTCAGATTTTTAAAGTTACTTTATAACCATTTTGTCCATTTGATGCCATTGTTTATCATCTTTTGAGAAAAAAGTTCTG
 241 TCATACCCTTCTCTCCACAAAAAAGAGACTGAGAGGGAGATCAAGTGAAAGGGTGCAAGCGAACTTAGTGACTCCTTGAG
 321 GTGTTTGTCAGTTTTGGCTTTTTTCTTCTTTGTTGTATTCTTTATGTATTGTCTTGATGTACTTAATATTACCTGAGTTT
 401 GAAATGGATGAAGACAGCTGCTACCATTAAGGACCAAATTTTATGCTACCACTAAACAAAAATACCCACTCAGTCTGTGT
 481 TAAATTGTATGTCTTTTTAAAGGTATTTAAAGATTCAACTAAGCTTTAAAGAGGGCTGAGCAGCTCAGGAAGCCTGTAAT
 561 GTGGGCATAACTCTTTGGACCTGATCTTGATGCTTCTGCTGCTCTGTTAGCCTCTGAAGAGCAATATCTAATTTATTATT
 641 ACTGTAATTTTTTAAAAGGCTTTAAAGTGCCTCAGGGGTCCCCTGAAACTAATTTTCTATTTCTGGGATTCCCTGGATTC
 721 ATTATATGAGATGGTGACATGATTAGAGGAATTCTTTTTTAGTATGAAAATTGTCCCTTTTCTTCTTCAGTACTTGCCTC
 801 CTTGCTGGCATTGAATTAACACAGGGACAAAATTTGGTTAATTTTTTATTTCTAACTCTCCCAACAAACCCCTGTTGCCC
 881 AGTATTTGTTTGGTGGCCTTTAACCACCTGAGGGAAAAAATGAGCTTATTCAAGCTGCCAATATTTATCTATGGGCTGTA
 961 GCAGTACACTGAATTGTACTGTGCCAGGGATATTGAGATGCTCTGGGGGTGTATTGTATACCTGCCAGTTTTCTTCATTT
1041 CTGAATTGAGTTTTCTTTTCTTGATGTTGGTTTCCTTCATATCACCTCAAGGTTTAGATTTGTGAAGGAATAAGCATGAT
1121 GGAAATAATAGTCTTGAAAGGAGATATGTTGTATATAATCAGGAGGAAGAGGAAGGAAGGACTTACCCATTTTGATATTT
1201 TGCTGTAGGTGGCCAGTTTTGTTTCTCATAGGGAAATCTGACCCACCTGTCATGTTGGCTCCTAAGGAACTGCTGTTGTA
1281 AGCGGCTCATCAAGAGTTGAACTTCACGTAGCCTTGTTGGGAATATGGAAAAGGAAGAAAGCCACAGGACTGCCCATTCA
1361 GTCTTGGGAAGATTGGGATGATTCTGCACAAGCAAAAATGACTGAAGTTTATGTATAGACACACCTCTACCAATCCATCT
1441 TCAGCTGACTGAATGTTGTATGATAGCCCTTCTCCAAAGCAGAGGTAGAATGTTCAGGTTTCACCATGGATTTTCTACTT
1521 ATTTCGTTTTTGGAATCAGCTTACAGATTCCAGGTCCCTTTTGTATATATTCTTTATTCTTTTGCTTTTTTAAAAAATAA
1601 TTTTGTTTCATATTTAAAGCACTTGTATTAGTCAATGTTTCGTGTTCCGCATTATTTGAACCATTTGCCCTTACAGAAAG
1681 AGAAATACTTGTTTGTGTTTTAAATAAAACTGATGTAGGAAAGTCTTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gcggcagggcccucgGGGUGAGu 5'
                         ||||||| 
Target 5' cactaaacaaaaataCCCACTCa 3'
 450 - 472 140.00 -16.20
2 
miRNA  3' gcggCAGGGCCCUCG-GGGUGAGu 5'
              | | | ||| : ||||:|| 
Target 5' gaaaGCCACAGGACTGCCCATTCa 3'
 1337 - 1360 135.00 -17.40
3 
miRNA  3' gcggcagggcCCUCG--GGGUGAGu 5'
                    ||| :  ||||:|: 
Target 5' gaggaaggaaGGACTTACCCATTTt 3'
 1169 - 1193 111.00 -10.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30174270 12 COSMIC
COSN20073576 22 COSMIC
COSN30486574 29 COSMIC
COSN30165026 35 COSMIC
COSN31526670 43 COSMIC
COSN30489496 56 COSMIC
COSN31548804 60 COSMIC
COSN6019542 61 COSMIC
COSN31539424 150 COSMIC
COSN30539711 254 COSMIC
COSN25980308 265 COSMIC
COSN30174205 402 COSMIC
COSN31547950 432 COSMIC
COSN31522035 582 COSMIC
COSN30539708 712 COSMIC
COSN26576743 750 COSMIC
COSN31538177 831 COSMIC
COSN30539706 853 COSMIC
COSN30539703 932 COSMIC
COSN30539682 950 COSMIC
COSN31536763 990 COSMIC
COSN31595830 1021 COSMIC
COSN19326778 1058 COSMIC
COSN31520225 1259 COSMIC
COSN31550020 1263 COSMIC
COSN20577868 1268 COSMIC
COSN26580250 1308 COSMIC
COSN14851856 1346 COSMIC
COSN6019543 1354 COSMIC
COSN31556527 1427 COSMIC
COSN31488430 1503 COSMIC
COSN28703739 1540 COSMIC
COSN30539688 1580 COSMIC
COSN31515297 1580 COSMIC
COSN19660209 1634 COSMIC
COSN30544171 1650 COSMIC
COSN16417306 1688 COSMIC
COSN28762575 1695 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs772909565 2 dbSNP
rs760611223 9 dbSNP
rs766349499 10 dbSNP
rs752740009 17 dbSNP
rs758334532 19 dbSNP
rs764284296 19 dbSNP
rs1305810427 21 dbSNP
rs1345735614 21 dbSNP
rs373391082 22 dbSNP
rs751596212 22 dbSNP
rs929730685 22 dbSNP
rs572435498 23 dbSNP
rs757429307 26 dbSNP
rs781583570 29 dbSNP
rs909652446 34 dbSNP
rs746243663 35 dbSNP
rs940996585 37 dbSNP
rs541325172 39 dbSNP
rs780749126 45 dbSNP
rs1489442649 47 dbSNP
rs1264355836 50 dbSNP
rs1275612490 52 dbSNP
rs1210437109 55 dbSNP
rs766348941 57 dbSNP
rs1376011137 60 dbSNP
rs1039396945 62 dbSNP
rs1210967389 65 dbSNP
rs188734964 69 dbSNP
rs1307021591 76 dbSNP
rs1293291746 84 dbSNP
rs1216266782 91 dbSNP
rs530192881 93 dbSNP
rs1340822208 95 dbSNP
rs550009922 96 dbSNP
rs1412525821 99 dbSNP
rs1376948838 103 dbSNP
rs1302885242 109 dbSNP
rs996470108 110 dbSNP
rs559402046 113 dbSNP
rs890647664 133 dbSNP
rs1010302351 140 dbSNP
rs1474332387 162 dbSNP
rs1258486631 171 dbSNP
rs1182681229 181 dbSNP
rs1020763291 187 dbSNP
rs1249688432 196 dbSNP
rs1280661192 198 dbSNP
rs1206527269 207 dbSNP
rs1329002763 208 dbSNP
rs532418436 210 dbSNP
rs1000116443 227 dbSNP
rs1357168463 229 dbSNP
rs1312917652 239 dbSNP
rs1390467807 243 dbSNP
rs1370536191 244 dbSNP
rs1335886617 245 dbSNP
rs753759544 256 dbSNP
rs1467626873 259 dbSNP
rs1401716755 263 dbSNP
rs1164875926 264 dbSNP
rs552573964 265 dbSNP
rs1370574169 266 dbSNP
rs992734759 267 dbSNP
rs1418784252 282 dbSNP
rs1248490124 285 dbSNP
rs1180642261 288 dbSNP
rs1458133184 291 dbSNP
rs1024126238 299 dbSNP
rs367949787 301 dbSNP
rs982650853 302 dbSNP
rs1472255592 307 dbSNP
rs1265879758 324 dbSNP
rs909589546 343 dbSNP
rs1314818526 349 dbSNP
rs1308487024 352 dbSNP
rs1446833567 366 dbSNP
rs1156829420 377 dbSNP
rs941122630 380 dbSNP
rs1325749237 389 dbSNP
rs1461733772 408 dbSNP
rs1162307368 419 dbSNP
rs1388058070 424 dbSNP
rs1411161110 425 dbSNP
rs1329026557 427 dbSNP
rs975073931 434 dbSNP
rs1349324883 437 dbSNP
rs11557180 452 dbSNP
rs180808990 455 dbSNP
rs1295620850 457 dbSNP
rs1362321213 460 dbSNP
rs547704922 466 dbSNP
rs1244461309 467 dbSNP
rs879042650 484 dbSNP
rs1191667218 486 dbSNP
rs1453314424 490 dbSNP
rs1267765033 495 dbSNP
rs3881954 511 dbSNP
rs1484790091 515 dbSNP
rs890731907 519 dbSNP
rs1196588220 520 dbSNP
rs149429456 521 dbSNP
rs2788898 544 dbSNP
rs1482096011 546 dbSNP
rs904563846 550 dbSNP
rs548223993 553 dbSNP
rs866435650 557 dbSNP
rs1475420282 560 dbSNP
rs1383288040 562 dbSNP
rs1186496556 564 dbSNP
rs1000273857 568 dbSNP
rs1307753901 569 dbSNP
rs1394547023 571 dbSNP
rs1366492932 574 dbSNP
rs1478952663 578 dbSNP
rs1378095952 581 dbSNP
rs1192416682 589 dbSNP
rs1426462475 591 dbSNP
rs1034302798 596 dbSNP
rs1216874957 599 dbSNP
rs894506761 607 dbSNP
rs4019809 610 dbSNP
rs1201713964 613 dbSNP
rs1168115728 622 dbSNP
rs1275910384 623 dbSNP
rs1227359623 640 dbSNP
rs1338897101 644 dbSNP
rs1280555853 647 dbSNP
rs1400815338 681 dbSNP
rs1375115780 683 dbSNP
rs1311328478 686 dbSNP
rs1416201944 700 dbSNP
rs374959867 714 dbSNP
rs867410547 724 dbSNP
rs368834613 727 dbSNP
rs982984742 740 dbSNP
rs1016807288 743 dbSNP
rs962446190 749 dbSNP
rs1189216924 755 dbSNP
rs1395949401 763 dbSNP
rs975188849 765 dbSNP
rs1328539339 773 dbSNP
rs2785995 776 dbSNP
rs1271760500 777 dbSNP
rs4019811 778 dbSNP
rs1316651090 805 dbSNP
rs1260362160 806 dbSNP
rs1219592932 807 dbSNP
rs933619792 811 dbSNP
rs1282588832 812 dbSNP
rs1297088920 823 dbSNP
rs538335348 831 dbSNP
rs2653982 835 dbSNP
rs4019813 857 dbSNP
rs11557179 860 dbSNP
rs986495718 862 dbSNP
rs1328335452 868 dbSNP
rs1463978594 869 dbSNP
rs753990932 873 dbSNP
rs912093960 879 dbSNP
rs558179106 882 dbSNP
rs1282390672 885 dbSNP
rs4019814 889 dbSNP
rs4019815 891 dbSNP
rs1801840 913 dbSNP
rs1199794666 930 dbSNP
rs1164572295 932 dbSNP
rs1253879340 935 dbSNP
rs1472956133 936 dbSNP
rs946320292 942 dbSNP
rs1179101539 945 dbSNP
rs1193497091 946 dbSNP
rs868075852 950 dbSNP
rs1389121866 952 dbSNP
rs1240521642 953 dbSNP
rs1199843013 956 dbSNP
rs1334539091 965 dbSNP
rs1042273919 968 dbSNP
rs550482332 969 dbSNP
rs1175043851 977 dbSNP
rs1357379736 994 dbSNP
rs1395143659 999 dbSNP
rs1379236263 1002 dbSNP
rs1444603769 1002 dbSNP
rs1331886615 1005 dbSNP
rs879172364 1012 dbSNP
rs1347889269 1023 dbSNP
rs113971217 1029 dbSNP
rs1405562687 1051 dbSNP
rs1406739920 1052 dbSNP
rs2785994 1058 dbSNP
rs904721579 1062 dbSNP
rs1301568843 1065 dbSNP
rs1440942450 1066 dbSNP
rs1387635016 1067 dbSNP
rs1380386229 1069 dbSNP
rs1179812882 1071 dbSNP
rs936071348 1079 dbSNP
rs1245318359 1082 dbSNP
rs1055785289 1083 dbSNP
rs1452578087 1096 dbSNP
rs1283765595 1111 dbSNP
rs1238085285 1128 dbSNP
rs1238262559 1146 dbSNP
rs1383078459 1154 dbSNP
rs1320156711 1173 dbSNP
rs1310163026 1175 dbSNP
rs1233447731 1176 dbSNP
rs1365454313 1182 dbSNP
rs1276579363 1184 dbSNP
rs1436874106 1185 dbSNP
rs1344405654 1186 dbSNP
rs1295895420 1187 dbSNP
rs571700310 1192 dbSNP
rs1360585041 1194 dbSNP
rs1172525412 1196 dbSNP
rs1433079238 1198 dbSNP
rs1014177619 1199 dbSNP
rs1193448208 1203 dbSNP
rs1045735277 1207 dbSNP
rs1304333349 1208 dbSNP
rs1241895388 1220 dbSNP
rs1214719201 1222 dbSNP
rs1489422246 1227 dbSNP
rs887024086 1230 dbSNP
rs4019818 1242 dbSNP
rs1004167451 1244 dbSNP
rs1310541817 1246 dbSNP
rs1303247421 1262 dbSNP
rs111465149 1282 dbSNP
rs1017166522 1284 dbSNP
rs1361010124 1285 dbSNP
rs962559906 1289 dbSNP
rs1340783304 1291 dbSNP
rs1311923459 1292 dbSNP
rs996700549 1301 dbSNP
rs1028046432 1305 dbSNP
rs4019819 1308 dbSNP
rs955114166 1309 dbSNP
rs1423338690 1317 dbSNP
rs1192004442 1328 dbSNP
rs11557178 1333 dbSNP
rs1195086784 1348 dbSNP
rs764986245 1357 dbSNP
rs1181513625 1359 dbSNP
rs185117021 1364 dbSNP
rs4019820 1368 dbSNP
rs4019821 1369 dbSNP
rs977728260 1371 dbSNP
rs140198290 1383 dbSNP
rs936143988 1389 dbSNP
rs1255881638 1394 dbSNP
rs2365983 1408 dbSNP
rs1055898512 1409 dbSNP
rs1454635035 1412 dbSNP
rs1158979750 1414 dbSNP
rs2365984 1418 dbSNP
rs915958204 1419 dbSNP
rs868852433 1428 dbSNP
rs1380700669 1432 dbSNP
rs1302980908 1435 dbSNP
rs752394356 1440 dbSNP
rs1400158935 1454 dbSNP
rs1443445879 1459 dbSNP
rs1046137652 1462 dbSNP
rs1326794908 1464 dbSNP
rs1004517739 1465 dbSNP
rs1038266623 1468 dbSNP
rs367873607 1485 dbSNP
rs1318587838 1488 dbSNP
rs1457391881 1489 dbSNP
rs996648300 1490 dbSNP
rs1200466119 1492 dbSNP
rs1228912894 1496 dbSNP
rs190709456 1497 dbSNP
rs1242141941 1498 dbSNP
rs1326774855 1506 dbSNP
rs1313028415 1512 dbSNP
rs1215207652 1519 dbSNP
rs758090541 1523 dbSNP
rs371833035 1526 dbSNP
rs16865261 1527 dbSNP
rs1252044327 1531 dbSNP
rs1401469410 1532 dbSNP
rs7311 1540 dbSNP
rs966382189 1557 dbSNP
rs1456550507 1559 dbSNP
rs1370373591 1566 dbSNP
rs979523861 1571 dbSNP
rs1410268652 1578 dbSNP
rs1439098337 1580 dbSNP
rs926176290 1583 dbSNP
rs559825516 1592 dbSNP
rs1165780906 1593 dbSNP
rs1458203665 1598 dbSNP
rs1266383987 1610 dbSNP
rs1207802743 1611 dbSNP
rs746880547 1613 dbSNP
rs528454580 1622 dbSNP
rs1456463439 1628 dbSNP
rs41264267 1636 dbSNP
rs916115414 1637 dbSNP
rs1482708037 1641 dbSNP
rs1374114506 1642 dbSNP
rs1410396376 1643 dbSNP
rs147304730 1649 dbSNP
rs1045837784 1650 dbSNP
rs781097907 1658 dbSNP
rs1419399063 1662 dbSNP
rs940007512 1665 dbSNP
rs1038386662 1671 dbSNP
rs1440201867 1674 dbSNP
rs1234842471 1679 dbSNP
rs1195984059 1682 dbSNP
rs745645181 1683 dbSNP
rs1320813477 1689 dbSNP
rs7312 1695 dbSNP
rs1049578779 1711 dbSNP
rs1483080554 1715 dbSNP
rs1182132404 1723 dbSNP
rs1287504551 1726 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gcggcagggcccucgGGGUGAGu 5'
                         ||||||| 
Target 5' cacuaaacaaaaauaCCCACUCa 3'
 		5 - 27
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_014827 | 3UTR | AAAAUACCCACUCAGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000332127.4 | 3UTR | CUACCACUAAACAAAAAUACCCACUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
85 hsa-miR-4745-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100716 TJAP1 tight junction associated protein 1 2 2
MIRT183592 ZC3H11A zinc finger CCCH-type containing 11A 2 2
MIRT338035 DAZAP2 DAZ associated protein 2 2 4
MIRT395801 SPCS3 signal peptidase complex subunit 3 2 2
MIRT443946 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT450579 HIST1H2BG histone cluster 1 H2B family member g 2 6
MIRT451616 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452330 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453278 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT455213 GNL1 G protein nucleolar 1 (putative) 2 2
MIRT455469 LYPLA2 lysophospholipase II 2 2
MIRT456502 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456686 LDB1 LIM domain binding 1 2 2
MIRT456914 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457602 IDS iduronate 2-sulfatase 2 2
MIRT457849 RNASEH2B ribonuclease H2 subunit B 2 4
MIRT458454 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT460178 UNK unkempt family zinc finger 2 6
MIRT461464 SLC19A3 solute carrier family 19 member 3 2 2
MIRT464738 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT465278 TRIM28 tripartite motif containing 28 2 2
MIRT468449 SETD1B SET domain containing 1B 2 2
MIRT468619 SUMO1 small ubiquitin-like modifier 1 2 6
MIRT469151 RNF121 ring finger protein 121 2 2
MIRT470072 PTGES2 prostaglandin E synthase 2 2 2
MIRT470171 PSMD11 proteasome 26S subunit, non-ATPase 11 2 4
MIRT473155 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT474307 LAMC1 laminin subunit gamma 1 2 2
MIRT474781 KIAA0895L KIAA0895 like 2 2
MIRT476482 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT477612 EFNA3 ephrin A3 2 2
MIRT479523 CDCA4 cell division cycle associated 4 2 2
MIRT479972 CARD10 caspase recruitment domain family member 10 2 2
MIRT480409 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480425 C17orf85 nuclear cap binding subunit 3 2 2
MIRT483571 SYT2 synaptotagmin 2 2 2
MIRT483663 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484531 POLD3 DNA polymerase delta 3, accessory subunit 2 2
MIRT484614 SIX3 SIX homeobox 3 2 6
MIRT485896 ZFP36 ZFP36 ring finger protein 2 2
MIRT486504 MYH11 myosin heavy chain 11 2 2
MIRT487506 GRK5 G protein-coupled receptor kinase 5 2 2
MIRT488851 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489463 MSC musculin 2 2
MIRT491168 LRP3 LDL receptor related protein 3 2 2
MIRT496626 TMEM67 transmembrane protein 67 2 2
MIRT497615 ANG angiogenin 2 2
MIRT497765 KIAA0895 KIAA0895 2 2
MIRT499679 MRE11A MRE11 homolog, double strand break repair nuclease 2 6
MIRT499772 SLC29A2 solute carrier family 29 member 2 2 2
MIRT501744 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT504993 ZNF652 zinc finger protein 652 2 2
MIRT511663 HIST1H3C histone cluster 1 H3 family member c 2 2
MIRT511689 HIST1H2BO histone cluster 1 H2B family member o 2 4
MIRT511702 HIST1H2BL histone cluster 1 H2B family member l 2 4
MIRT511733 HIST1H2BE histone cluster 1 H2B family member e 2 8
MIRT512857 TBC1D13 TBC1 domain family member 13 2 2
MIRT513443 EMP1 epithelial membrane protein 1 2 6
MIRT515680 TFPI tissue factor pathway inhibitor 2 2
MIRT523528 GLUL glutamate-ammonia ligase 2 2
MIRT525545 PHB2 prohibitin 2 2 4
MIRT526208 SNX24 sorting nexin 24 2 2
MIRT531555 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT533763 TMEM135 transmembrane protein 135 2 2
MIRT545581 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT552433 ZNF460 zinc finger protein 460 2 2
MIRT561158 BCL2L12 BCL2 like 12 2 2
MIRT562344 EXOSC2 exosome component 2 2 2
MIRT570658 KDM6B lysine demethylase 6B 2 2
MIRT571075 TCHHL1 trichohyalin like 1 2 2
MIRT571331 TPCN2 two pore segment channel 2 2 2
MIRT571601 TOB2 transducer of ERBB2, 2 2 2
MIRT573012 RPP25 ribonuclease P and MRP subunit p25 2 2
MIRT609042 EP300 E1A binding protein p300 2 2
MIRT613397 DNAH17 dynein axonemal heavy chain 17 2 2
MIRT635588 TTC9C tetratricopeptide repeat domain 9C 2 2
MIRT644753 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT661117 FPR1 formyl peptide receptor 1 2 2
MIRT690102 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT694971 PLAC8 placenta specific 8 2 2
MIRT695514 ALPI alkaline phosphatase, intestinal 2 2
MIRT695576 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT699569 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT701990 MIER3 MIER family member 3 2 2
MIRT725462 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4745-5p Cisplatin approved 84093 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4745 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4745 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4745 Plx-4720 24180719 NSC757438 sensitive High Thyroid Cancer cell line (8505c, BCPAP)
hsa-mir-4745 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4745 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4745 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-4745 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4745-5p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4745-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4745-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4745-5p Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4745-5p Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4745-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4745-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-4745-5p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-4745-5p Docetaxel 148124 NSC628503 approved sensitive High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-4745-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4745-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-4745-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-4745-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4745-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4745-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4745-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4745-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4745-5p Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4745-5p Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4745-5p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-4745-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4745-5p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-4745-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4745-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4745-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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