miRTarBase - #MIRT186378


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pre-miRNA Information
pre-miRNA hsa-mir-646   
Genomic Coordinates chr20: 60308474 - 60308567
Synonyms MIRN646, hsa-mir-646, MIR646
Description Homo sapiens miR-646 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-646
Sequence 61| AAGCAGCUGCCUCUGAGGC |79
Evidence Experimental
Experiments SAGE
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs750684400 6 dbSNP
rs112880289 10 dbSNP
rs553679341 11 dbSNP
rs941692683 13 dbSNP
rs6513497 14 dbSNP
rs1431341059 18 dbSNP
rs1479355932 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PNRC2   
Synonyms -
Description proline rich nuclear receptor coactivator 2
Transcript NM_017761   
Expression
Putative miRNA Targets on PNRC2
3'UTR of PNRC2
(miRNA target sites are highlighted)		 
>PNRC2|NM_017761|3'UTR
   1 AATAAGACAAATGTTTAAATTTAGTTATGTTCACGGATAGTTGTCAATTGGTCTGAAACAAATTCGCTAGGGAATCTATT
  81 TGTGTAGAACTAATTAATGTAAAAAAAATAGACCATCTCGTGTTGTGTGCACTGTGATATAATGGTAGTATCAGTGCAAC
 161 TTAAACTAATGATTGTACTTGATATTAAGTGTTCTCAACTGAGTAACTTTTAAGTGGAAACCAAGTTTAGATTTGGGGAG
 241 TGGTAAAGGAATCAGCTTTTTCTATTGTTAGGGGAAGACAGTAATTTATCATTCATGGACCAGTAGATTGTTGAAAGTTG
 321 GTGAATCGGATTATAAGCTTCTAGCTAACACAAGGATTCAGAATTAGGTAAACATCTGAAGGTTTAGTATATTAGAAACA
 401 CCCAAACCAGTAATATGCTAACCTGATGCACTGCTGAAAGAAAATGTGAATTTTTCGTAATAATTGCATTTTAGTGAATT
 481 GTACAGTGGGTGGAAAGGGCATTTGGAGCTCATTAGAATGAGACATAGTACACCCCAATGGCCCTGTTTATTAAATGTAG
 561 TGGATTAAGTGTCTGTCAACAAATACACCAAAACCATTTTTTATAGAAACAGTATTTAATGGTCACTCAATAGCTTTCAA
 641 AATACATTTTTGTATTACAGCACTGCACAAGCTATTCTAATAGTGCTCTGGCCTCATCATTCCTGCAAAGCTTGCTTTGG
 721 GGAGTTGGATAATGTGAAAATTTTAAGTACCTAGGGGAGAAAGAGCCATGTAAATATCTGTAATAAACTTGTAGCATATG
 801 TAAAGTTTTCTTGGCCTTTATCTTACAAAAATGGAGTATTTTAGTATGAATTTGCTGAATGTAAGACCGTGGACTGTTTT
 881 TTATAATATGGCCTAATTTTAAAGGTCCAAAATAACTTGTTTTTAAAGTTTGCCCTTGTGCTAAAGTGCCAGTGTATGTA
 961 TGTTATACTTGATTTGGTTGTAAACTATATTTCAAAGTAAACCCTAGTGTAATAAGTTTTATAACTAAAAAGGTTTAAGC
1041 TGCTAAAACTATTTTTAAGAGATGTGAAATGCAGTATGGGACTATCTTTTTTTCCTCCTCTAAGCCCAAAGATTAACTAG
1121 AGTCCCTCCAACCTTATAGATTGTTGGCTTTCACAATCTTATAACCTAGGATACAGGTAGTTTCGAGTATGGTGCCAGTG
1201 ATGTTTTGTTTTTGTTTGGTCAAGGGGTAGGTGCAACCCAATGGACCACTTATGCAAAAGATGTAAACTCTTGCATAATA
1281 CATTGATAACATGTTTTGCCAACTTTAAATGCTTAAACATAAGCGAAACCAGTAGCAAGTATGTGGGTCAGCTTAAAAAT
1361 TTTGATTGTTAATGCCCTATTTTCTAATTTGGCACCTCTTGATGCCTAAGCAGGTAAGCAGATGCCTAAGCTGTATTTCT
1441 CCAAATAAATCAAGATGAAGTACTGCCCAAGTTAAATATTGATAGCCTAAAGACAAGTTTATGTAGTACTTAATGTACAT
1521 GATATGAATGTGAAGCATAAAATTAAATAAAATTTTTCCCCATTGGCTTGGTTTTATTTTAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cggagUCUCCG---UCGACGAa 5'
               | |||:   ||||||| 
Target 5' actaaAAAGGTTTAAGCTGCTa 3'
 1024 - 1045 146.00 -12.10
2 
miRNA  3' cggaGUCUCCG---UCGACGaa 5'
              |||| ||   |||||:  
Target 5' taagCAGATGCCTAAGCTGTat 3'
 1415 - 1436 119.00 -10.20
3 
miRNA  3' cggAG-UCUCCGUCGACGaa 5'
             || ||:||:|| |||  
Target 5' tggTCAAGGGGTAGGTGCaa 3'
 1217 - 1236 112.00 -17.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31486733 20 COSMIC
COSN30132017 36 COSMIC
COSN31486732 36 COSMIC
COSN32065755 38 COSMIC
COSN32065756 66 COSMIC
COSN20094518 164 COSMIC
COSN32062067 168 COSMIC
COSN8637893 760 COSMIC
COSN21802869 869 COSMIC
COSN31569887 1266 COSMIC
COSN31585100 1326 COSMIC
COSN26633467 1441 COSMIC
COSN30143006 1442 COSMIC
COSN29286941 1500 COSMIC
COSN20094533 1530 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1363442700 3 dbSNP
rs1002585507 4 dbSNP
rs759561879 8 dbSNP
rs771276986 9 dbSNP
rs1219338609 14 dbSNP
rs1289825920 20 dbSNP
rs1488308327 21 dbSNP
rs774755416 27 dbSNP
rs556708834 29 dbSNP
rs1436157197 30 dbSNP
rs752843058 35 dbSNP
rs756400323 36 dbSNP
rs3211051 38 dbSNP
rs1173232432 39 dbSNP
rs1440042027 41 dbSNP
rs1160285155 44 dbSNP
rs1486870246 46 dbSNP
rs765120866 48 dbSNP
rs750301556 49 dbSNP
rs1474477187 55 dbSNP
rs569144050 56 dbSNP
rs7368202 66 dbSNP
rs1156469495 68 dbSNP
rs1346496951 73 dbSNP
rs1311693440 77 dbSNP
rs1453895094 77 dbSNP
rs1373574405 79 dbSNP
rs1416540524 84 dbSNP
rs375238270 85 dbSNP
rs1293740932 88 dbSNP
rs1372314806 91 dbSNP
rs1223468656 96 dbSNP
rs1305167574 98 dbSNP
rs1279609989 101 dbSNP
rs201235780 101 dbSNP
rs1485017926 107 dbSNP
rs1213633448 108 dbSNP
rs1238466021 109 dbSNP
rs3211053 110 dbSNP
rs1375603400 112 dbSNP
rs1439865363 114 dbSNP
rs1172548131 120 dbSNP
rs1373080060 120 dbSNP
rs1238331152 121 dbSNP
rs1436555691 121 dbSNP
rs1439779646 126 dbSNP
rs1299608253 130 dbSNP
rs960759334 132 dbSNP
rs1375800871 133 dbSNP
rs1241148726 140 dbSNP
rs368096122 141 dbSNP
rs1348384859 142 dbSNP
rs1345792257 143 dbSNP
rs1237201394 144 dbSNP
rs1279991145 146 dbSNP
rs1437710314 149 dbSNP
rs991980975 150 dbSNP
rs1234892523 154 dbSNP
rs1457980241 156 dbSNP
rs1212693938 159 dbSNP
rs201521381 159 dbSNP
rs1192593625 160 dbSNP
rs199913886 162 dbSNP
rs758930694 162 dbSNP
rs760138914 162 dbSNP
rs142213874 163 dbSNP
rs769098206 163 dbSNP
rs1441709873 167 dbSNP
rs1172602327 168 dbSNP
rs375888290 174 dbSNP
rs1408072834 179 dbSNP
rs1172348567 185 dbSNP
rs919081977 186 dbSNP
rs1437241550 197 dbSNP
rs950731043 202 dbSNP
rs1369002543 208 dbSNP
rs1443226064 227 dbSNP
rs113450395 228 dbSNP
rs1275454075 232 dbSNP
rs572741113 241 dbSNP
rs1339311893 244 dbSNP
rs1213319706 249 dbSNP
rs1275612049 250 dbSNP
rs1318999091 257 dbSNP
rs1213414377 262 dbSNP
rs1250773112 265 dbSNP
rs1177675917 270 dbSNP
rs1198953538 271 dbSNP
rs540367512 274 dbSNP
rs984724798 277 dbSNP
rs1474421168 278 dbSNP
rs1169561321 279 dbSNP
rs879142073 280 dbSNP
rs1424125975 281 dbSNP
rs909086181 285 dbSNP
rs376601694 286 dbSNP
rs1162469945 297 dbSNP
rs1407228646 305 dbSNP
rs1324361724 314 dbSNP
rs1325907605 318 dbSNP
rs1429289334 319 dbSNP
rs369387860 322 dbSNP
rs558666939 328 dbSNP
rs1038703594 329 dbSNP
rs1233069080 333 dbSNP
rs201658893 336 dbSNP
rs1336575423 338 dbSNP
rs1283007204 341 dbSNP
rs923046058 342 dbSNP
rs879007383 344 dbSNP
rs1263846764 351 dbSNP
rs576986974 355 dbSNP
rs1185539700 367 dbSNP
rs1419756689 372 dbSNP
rs1473931086 374 dbSNP
rs1164017493 379 dbSNP
rs1384474737 388 dbSNP
rs1051304836 400 dbSNP
rs1361734514 404 dbSNP
rs1414698454 408 dbSNP
rs1291883471 411 dbSNP
rs1342616096 416 dbSNP
rs1330138674 421 dbSNP
rs1245123055 437 dbSNP
rs1402600989 445 dbSNP
rs200223599 447 dbSNP
rs1348043202 450 dbSNP
rs1206393813 451 dbSNP
rs1485342250 453 dbSNP
rs1208625523 457 dbSNP
rs1180762183 458 dbSNP
rs1424209808 458 dbSNP
rs892639903 458 dbSNP
rs1363451391 460 dbSNP
rs1010114899 462 dbSNP
rs1160599217 464 dbSNP
rs1380981903 469 dbSNP
rs1434691060 477 dbSNP
rs1311564487 480 dbSNP
rs1404936475 482 dbSNP
rs1043996402 484 dbSNP
rs1333628943 488 dbSNP
rs1241867675 490 dbSNP
rs1309427925 497 dbSNP
rs1346492184 503 dbSNP
rs1231385293 508 dbSNP
rs1282412089 510 dbSNP
rs904079710 512 dbSNP
rs1195011646 514 dbSNP
rs1002232993 518 dbSNP
rs1436343975 522 dbSNP
rs1180717071 524 dbSNP
rs1238914169 526 dbSNP
rs1171797450 528 dbSNP
rs1453907538 528 dbSNP
rs1379898020 529 dbSNP
rs1466944505 539 dbSNP
rs1167766189 558 dbSNP
rs1394769585 560 dbSNP
rs1448598684 562 dbSNP
rs1331652326 566 dbSNP
rs753174590 570 dbSNP
rs1272804701 585 dbSNP
rs1302675695 587 dbSNP
rs1312767440 589 dbSNP
rs1226580774 590 dbSNP
rs1249450681 595 dbSNP
rs1319696728 606 dbSNP
rs1199000311 611 dbSNP
rs1258975865 613 dbSNP
rs1468161777 616 dbSNP
rs1191837360 623 dbSNP
rs1269553874 632 dbSNP
rs1033625857 634 dbSNP
rs1193076919 635 dbSNP
rs1371744480 638 dbSNP
rs1467529771 644 dbSNP
rs1171760409 647 dbSNP
rs1393283564 668 dbSNP
rs960811330 669 dbSNP
rs763151968 672 dbSNP
rs1294830816 681 dbSNP
rs1367665287 686 dbSNP
rs1381617394 690 dbSNP
rs1043880 691 dbSNP
rs1342245048 699 dbSNP
rs1219029308 707 dbSNP
rs1272243930 715 dbSNP
rs751788978 719 dbSNP
rs1334524691 726 dbSNP
rs1219630725 730 dbSNP
rs1267356841 731 dbSNP
rs1488831356 734 dbSNP
rs1204580045 736 dbSNP
rs1261669901 737 dbSNP
rs1479050575 742 dbSNP
rs1194930671 744 dbSNP
rs1417571599 748 dbSNP
rs1166430108 754 dbSNP
rs1474046830 754 dbSNP
rs1350065772 757 dbSNP
rs1452460737 758 dbSNP
rs1286554135 760 dbSNP
rs1362385984 764 dbSNP
rs1400534962 767 dbSNP
rs1292511989 769 dbSNP
rs1353307707 771 dbSNP
rs1226863266 775 dbSNP
rs1315145919 776 dbSNP
rs1322492857 777 dbSNP
rs1238425991 778 dbSNP
rs1283965956 779 dbSNP
rs1489589337 781 dbSNP
rs1217957067 782 dbSNP
rs1482497509 784 dbSNP
rs1183917041 790 dbSNP
rs1414088321 793 dbSNP
rs1418086171 799 dbSNP
rs1156402572 808 dbSNP
rs1381613289 811 dbSNP
rs1420282589 823 dbSNP
rs1312168662 832 dbSNP
rs1373509389 845 dbSNP
rs1449966942 849 dbSNP
rs1380253680 858 dbSNP
rs1223418111 861 dbSNP
rs1307232972 861 dbSNP
rs878956676 869 dbSNP
rs1280265002 870 dbSNP
rs1310902141 875 dbSNP
rs1212692991 878 dbSNP
rs1238410776 881 dbSNP
rs1480141581 885 dbSNP
rs1176373779 886 dbSNP
rs1239509076 890 dbSNP
rs1439809438 893 dbSNP
rs1172423220 906 dbSNP
rs1422977313 908 dbSNP
rs1416096031 916 dbSNP
rs1176597180 917 dbSNP
rs1353684878 931 dbSNP
rs1441800861 933 dbSNP
rs1329594807 935 dbSNP
rs1447631907 938 dbSNP
rs1302682265 939 dbSNP
rs1366202011 942 dbSNP
rs1221427768 945 dbSNP
rs1279842170 950 dbSNP
rs1307252485 955 dbSNP
rs1197098043 958 dbSNP
rs1259618597 972 dbSNP
rs1457880643 985 dbSNP
rs1026316323 986 dbSNP
rs1244461592 988 dbSNP
rs1478995932 990 dbSNP
rs1191669479 991 dbSNP
rs1418649661 995 dbSNP
rs1463886373 996 dbSNP
rs950585272 997 dbSNP
rs1323047561 1004 dbSNP
rs1402739867 1004 dbSNP
rs985000274 1005 dbSNP
rs1275995499 1010 dbSNP
rs1439270446 1010 dbSNP
rs1361814032 1011 dbSNP
rs1217200733 1013 dbSNP
rs1280483442 1015 dbSNP
rs1318226293 1028 dbSNP
rs1212657349 1034 dbSNP
rs1287179363 1038 dbSNP
rs1452860609 1039 dbSNP
rs1221593691 1040 dbSNP
rs1241457937 1041 dbSNP
rs1476763645 1041 dbSNP
rs1195665815 1044 dbSNP
rs1424060468 1050 dbSNP
rs1478301722 1052 dbSNP
rs1162859569 1057 dbSNP
rs1388797694 1058 dbSNP
rs1407178330 1062 dbSNP
rs1324223946 1063 dbSNP
rs1360519001 1071 dbSNP
rs1398679569 1080 dbSNP
rs1300485002 1082 dbSNP
rs1341486137 1085 dbSNP
rs1233009341 1086 dbSNP
rs1016207620 1087 dbSNP
rs1282087799 1087 dbSNP
rs545631768 1087 dbSNP
rs1228398557 1094 dbSNP
rs1282939995 1096 dbSNP
rs1218682704 1098 dbSNP
rs1487302898 1098 dbSNP
rs1263689612 1105 dbSNP
rs1485240688 1108 dbSNP
rs1185082459 1114 dbSNP
rs1366951564 1123 dbSNP
rs1473861452 1130 dbSNP
rs1163966297 1134 dbSNP
rs1379742198 1135 dbSNP
rs1456084356 1138 dbSNP
rs1300621485 1142 dbSNP
rs1361674230 1156 dbSNP
rs1395818193 1163 dbSNP
rs964975131 1167 dbSNP
rs1341966351 1168 dbSNP
rs1448287350 1169 dbSNP
rs1307963925 1171 dbSNP
rs1350828646 1179 dbSNP
rs1241633604 1185 dbSNP
rs1197409094 1186 dbSNP
rs1346990914 1190 dbSNP
rs1198521593 1201 dbSNP
rs1257991903 1202 dbSNP
rs550685505 1204 dbSNP
rs1455259550 1205 dbSNP
rs1237755934 1209 dbSNP
rs563830626 1211 dbSNP
rs922931458 1212 dbSNP
rs1232826941 1215 dbSNP
rs1465973079 1217 dbSNP
rs1171253689 1223 dbSNP
rs932934679 1226 dbSNP
rs988567458 1228 dbSNP
rs912944941 1230 dbSNP
rs369821385 1244 dbSNP
rs1448373295 1245 dbSNP
rs1309275765 1253 dbSNP
rs1044264436 1254 dbSNP
rs904134221 1261 dbSNP
rs1345491095 1263 dbSNP
rs938256852 1265 dbSNP
rs1257676061 1268 dbSNP
rs1456557615 1272 dbSNP
rs1055085657 1276 dbSNP
rs1238849637 1280 dbSNP
rs896491198 1291 dbSNP
rs1197334764 1299 dbSNP
rs1379839314 1304 dbSNP
rs1013505624 1319 dbSNP
rs1170346046 1320 dbSNP
rs1026369051 1326 dbSNP
rs569361477 1333 dbSNP
rs1331495412 1334 dbSNP
rs1389345262 1336 dbSNP
rs1384523010 1337 dbSNP
rs1006084005 1340 dbSNP
rs1331552786 1354 dbSNP
rs1217790167 1360 dbSNP
rs1330685237 1360 dbSNP
rs1016505778 1362 dbSNP
rs1316355006 1362 dbSNP
rs1252008568 1375 dbSNP
rs1488215893 1380 dbSNP
rs964699529 1382 dbSNP
rs1270117263 1390 dbSNP
rs1434197757 1391 dbSNP
rs1193484777 1394 dbSNP
rs1421921867 1396 dbSNP
rs1478619881 1397 dbSNP
rs1170983528 1398 dbSNP
rs1367477525 1399 dbSNP
rs1294706297 1401 dbSNP
rs974661588 1401 dbSNP
rs1030219900 1406 dbSNP
rs1321828674 1407 dbSNP
rs1399307810 1407 dbSNP
rs1217979620 1409 dbSNP
rs954375264 1415 dbSNP
rs1218973671 1417 dbSNP
rs988452867 1426 dbSNP
rs1321291631 1430 dbSNP
rs1242711043 1438 dbSNP
rs1267302670 1441 dbSNP
rs1490673821 1443 dbSNP
rs1216480910 1445 dbSNP
rs757291691 1446 dbSNP
rs1261601035 1454 dbSNP
rs913003794 1455 dbSNP
rs1187409214 1464 dbSNP
rs1255053745 1468 dbSNP
rs111991512 1480 dbSNP
rs1368516038 1484 dbSNP
rs925439638 1494 dbSNP
rs938140147 1495 dbSNP
rs1362329063 1513 dbSNP
rs1400398078 1514 dbSNP
rs186671270 1515 dbSNP
rs1217495681 1519 dbSNP
rs1378808479 1519 dbSNP
rs1273330585 1522 dbSNP
rs1315002098 1524 dbSNP
rs147858858 1525 dbSNP
rs67992540 1525 dbSNP
rs1489173009 1527 dbSNP
rs201192474 1530 dbSNP
rs201677504 1531 dbSNP
rs1055309241 1532 dbSNP
rs896711867 1536 dbSNP
rs1207741576 1540 dbSNP
rs1482098983 1543 dbSNP
rs759333702 1544 dbSNP
rs1176171674 1545 dbSNP
rs1243334457 1545 dbSNP
rs949403996 1545 dbSNP
rs1451417628 1548 dbSNP
rs1420230294 1551 dbSNP
rs1175170432 1553 dbSNP
rs936871124 1554 dbSNP
rs1426418217 1555 dbSNP
rs1467350862 1556 dbSNP
rs1053892951 1557 dbSNP
rs1446131505 1560 dbSNP
rs1477096664 1563 dbSNP
rs895362271 1564 dbSNP
rs1012500181 1566 dbSNP
rs1224803981 1571 dbSNP
rs1418757293 1572 dbSNP
rs1310844205 1582 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 55629.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cggagUCUCCG---UCGACGAa 5'
               | |||:   ||||||| 
Target 5' acuaaAAAGGUUUAAGCUGCUa 3'
 		6 - 27
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000334351.7 | 3UTR | UUAUAACUAAAAAGGUUUAAGCUGCUAAAACUAUUUUUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.669 1.8e-4 -0.622 5.9e-4 24 Click to see details
GSE28260 Renal cortex and medulla 0.717 2.9e-3 0.659 7.1e-3 13 Click to see details
GSE42095 Differentiated embryonic stem cells -0.459 1.4e-2 -0.503 7.2e-3 23 Click to see details
GSE21687 Ependynoma primary tumors -0.186 7.1e-2 -0.143 1.3e-1 64 Click to see details
GSE17306 Multiple myeloma 0.179 1.1e-1 0.520 6.4e-5 49 Click to see details
GSE38226 Liver fibrosis 0.276 1.1e-1 0.075 3.7e-1 21 Click to see details
GSE17498 Multiple myeloma -0.189 1.2e-1 -0.210 9.7e-2 40 Click to see details
GSE32688 Pancreatic cancer -0.212 1.2e-1 -0.133 2.3e-1 32 Click to see details
GSE26953 Aortic valvular endothelial cells 0.213 1.6e-1 0.158 2.3e-1 24 Click to see details
GSE14794 Lymphoblastoid cells -0.099 1.8e-1 -0.060 2.9e-1 90 Click to see details
GSE21849 B cell lymphoma -0.161 2.0e-1 -0.202 1.5e-1 29 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.143 2.5e-1 -0.072 3.7e-1 25 Click to see details
GSE27834 Pluripotent stem cells -0.176 2.6e-1 -0.212 2.2e-1 16 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.012 4.8e-1 -0.487 1.5e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.012 4.8e-1 -0.487 1.5e-2 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
243 hsa-miR-646 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061535 BTG2 BTG anti-proliferation factor 2 2 4
MIRT064692 CCND2 cyclin D2 2 4
MIRT068834 FNDC3A fibronectin type III domain containing 3A 2 10
MIRT079080 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT092735 SETD5 SET domain containing 5 2 4
MIRT093692 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 6
MIRT096244 CANX calnexin 2 2
MIRT096296 SQSTM1 sequestosome 1 2 4
MIRT098839 PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 2 2
MIRT100229 PRR3 proline rich 3 2 4
MIRT156479 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT186378 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT196460 TAOK1 TAO kinase 1 2 2
MIRT211252 FGF2 fibroblast growth factor 2 2 2
MIRT215233 NPM1 nucleophosmin 1 2 4
MIRT215383 CREBRF CREB3 regulatory factor 2 2
MIRT224972 BAG4 BCL2 associated athanogene 4 2 4
MIRT235598 KIF3B kinesin family member 3B 2 2
MIRT249860 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT258407 FOXK1 forkhead box K1 2 2
MIRT269359 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT310455 REST RE1 silencing transcription factor 2 2
MIRT314057 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 8
MIRT322288 SLC39A14 solute carrier family 39 member 14 2 2
MIRT326311 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT329703 SCD stearoyl-CoA desaturase 2 2
MIRT341278 PABPN1 poly(A) binding protein nuclear 1 2 3
MIRT403798 AKIRIN1 akirin 1 2 2
MIRT438549 NOB1 NIN1/PSMD8 binding protein 1 homolog 1 1
MIRT441908 SEPN1 selenoprotein N 2 2
MIRT444125 ZNRF3 zinc and ring finger 3 2 2
MIRT445458 EXT1 exostosin glycosyltransferase 1 2 4
MIRT446500 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT446538 GOLGA8B golgin A8 family member B 2 2
MIRT447770 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT448438 TLL1 tolloid like 1 2 2
MIRT448768 GOLGA8A golgin A8 family member A 2 2
MIRT460749 SRP14 signal recognition particle 14 2 2
MIRT461556 ACTR3B ARP3 actin related protein 3 homolog B 2 2
MIRT463163 ZNF367 zinc finger protein 367 2 10
MIRT464234 VEGFA vascular endothelial growth factor A 5 12
MIRT464496 UCK2 uridine-cytidine kinase 2 2 2
MIRT465157 TSC22D2 TSC22 domain family member 2 2 2
MIRT466429 TFAP2A transcription factor AP-2 alpha 2 8
MIRT467395 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT468672 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT469407 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT470750 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT471947 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT472468 NAPG NSF attachment protein gamma 2 12
MIRT474571 KLHDC3 kelch domain containing 3 2 2
MIRT477443 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT480541 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT482110 AKT3 AKT serine/threonine kinase 3 2 4
MIRT485206 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT492318 SETD1B SET domain containing 1B 2 4
MIRT497144 TAPBP TAP binding protein 2 2
MIRT498976 ORC4 origin recognition complex subunit 4 2 8
MIRT499112 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT499448 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT500089 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 8
MIRT500317 ZNF622 zinc finger protein 622 2 8
MIRT500414 ZMAT3 zinc finger matrin-type 3 2 8
MIRT500572 USP53 ubiquitin specific peptidase 53 2 2
MIRT500596 UBN2 ubinuclein 2 2 10
MIRT500797 TLK1 tousled like kinase 1 2 8
MIRT500932 SRPR SRP receptor alpha subunit 2 6
MIRT500946 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 8
MIRT501081 SMAD7 SMAD family member 7 2 8
MIRT501515 PPTC7 PTC7 protein phosphatase homolog 2 6
MIRT501879 MOB4 MOB family member 4, phocein 2 8
MIRT502195 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT502630 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT502650 DCTN5 dynactin subunit 5 2 8
MIRT502914 CDCA4 cell division cycle associated 4 2 8
MIRT502938 CDC37L1 cell division cycle 37 like 1 2 8
MIRT502987 CCND1 cyclin D1 6 3
MIRT503181 AGO2 argonaute 2, RISC catalytic component 2 6
MIRT504532 ZNF620 zinc finger protein 620 2 6
MIRT504715 DLC1 DLC1 Rho GTPase activating protein 2 6
MIRT504967 ZNRF2 zinc and ring finger 2 2 2
MIRT505073 ZFHX4 zinc finger homeobox 4 2 6
MIRT505109 YTHDC1 YTH domain containing 1 2 6
MIRT505342 TMEM245 transmembrane protein 245 2 6
MIRT505389 TMEM100 transmembrane protein 100 2 2
MIRT505681 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT506162 PLAG1 PLAG1 zinc finger 2 8
MIRT506185 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 6
MIRT506354 NUP50 nucleoporin 50 2 6
MIRT506480 MYO5A myosin VA 2 6
MIRT506833 KIF23 kinesin family member 23 2 6
MIRT507310 FEM1B fem-1 homolog B 2 4
MIRT507847 CCNE2 cyclin E2 2 6
MIRT508670 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT509137 ZNF691 zinc finger protein 691 2 4
MIRT509686 ATAD5 ATPase family, AAA domain containing 5 2 4
MIRT512205 C1orf21 chromosome 1 open reading frame 21 2 6
MIRT518087 TRIM35 tripartite motif containing 35 2 2
MIRT518990 NNT nicotinamide nucleotide transhydrogenase 2 4
MIRT520964 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT521049 SLC2A3 solute carrier family 2 member 3 2 4
MIRT521192 SBNO1 strawberry notch homolog 1 2 6
MIRT521619 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT522770 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 2
MIRT533754 TMEM184B transmembrane protein 184B 2 2
MIRT534131 SNTB2 syntrophin beta 2 2 4
MIRT537159 GID8 GID complex subunit 8 homolog 2 2
MIRT537812 EFNB2 ephrin B2 2 4
MIRT538108 DDX6 DEAD-box helicase 6 2 2
MIRT540839 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541019 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT541145 PISD phosphatidylserine decarboxylase 2 2
MIRT541387 CDC42SE2 CDC42 small effector 2 2 2
MIRT541422 CBX4 chromobox 4 2 2
MIRT543521 PRSS21 protease, serine 21 2 2
MIRT543794 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 4
MIRT543831 GSG1 germ cell associated 1 2 2
MIRT544961 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT545182 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 4
MIRT545343 CCDC83 coiled-coil domain containing 83 2 2
MIRT545367 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545656 SPARC secreted protein acidic and cysteine rich 2 2
MIRT545678 DECR1 2,4-dienoyl-CoA reductase 1 2 2
MIRT545938 ZBTB44 zinc finger and BTB domain containing 44 2 4
MIRT546107 USP48 ubiquitin specific peptidase 48 2 4
MIRT546603 SALL1 spalt like transcription factor 1 2 4
MIRT546628 RTN4 reticulon 4 2 2
MIRT547321 NPTN neuroplastin 2 2
MIRT547660 KPNA3 karyopherin subunit alpha 3 2 2
MIRT547994 HCFC2 host cell factor C2 2 4
MIRT548048 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548098 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 4
MIRT548721 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT548938 CDK17 cyclin dependent kinase 17 2 2
MIRT549071 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT549272 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT549438 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT550462 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT550794 WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2 2
MIRT550819 FAM229B family with sequence similarity 229 member B 2 2
MIRT551537 EMB embigin 2 2
MIRT552031 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552340 ZNF704 zinc finger protein 704 2 2
MIRT552444 ZNF449 zinc finger protein 449 2 2
MIRT553116 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT553448 TOX4 TOX high mobility group box family member 4 2 2
MIRT553725 TBX18 T-box 18 2 2
MIRT553805 SZRD1 SUZ RNA binding domain containing 1 2 4
MIRT554696 RNF149 ring finger protein 149 2 2
MIRT554831 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT555139 PTPRD protein tyrosine phosphatase, receptor type D 2 2
MIRT555269 PRDM4 PR/SET domain 4 2 2
MIRT555312 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 4
MIRT555558 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT556379 LURAP1L leucine rich adaptor protein 1 like 2 2
MIRT556669 KMT2D lysine methyltransferase 2D 2 4
MIRT556853 KANK1 KN motif and ankyrin repeat domains 1 2 4
MIRT557476 GPR27 G protein-coupled receptor 27 2 4
MIRT558361 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT558385 DHX33 DEAH-box helicase 33 2 2
MIRT558502 CYP26B1 cytochrome P450 family 26 subfamily B member 1 2 4
MIRT558515 CTDSPL CTD small phosphatase like 2 4
MIRT558583 CREBL2 cAMP responsive element binding protein like 2 2 4
MIRT558641 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT558653 CNKSR3 CNKSR family member 3 2 2
MIRT558865 CD2AP CD2 associated protein 2 2
MIRT558888 CCNE1 cyclin E1 2 4
MIRT559002 CA8 carbonic anhydrase 8 2 2
MIRT559149 BTN3A3 butyrophilin subfamily 3 member A3 2 2
MIRT559999 RAB3IP RAB3A interacting protein 2 2
MIRT562023 LANCL1 LanC like 1 2 2
MIRT562474 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT562586 CBX2 chromobox 2 2 2
MIRT562595 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT562873 KIAA1456 KIAA1456 2 2
MIRT562989 KIAA0408 KIAA0408 2 4
MIRT563082 SLC25A12 solute carrier family 25 member 12 2 2
MIRT563499 DLGAP3 DLG associated protein 3 2 2
MIRT563892 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT564328 CCNT1 cyclin T1 2 2
MIRT564945 XKR7 XK related 7 2 2
MIRT564981 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT566302 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT566701 MTMR3 myotubularin related protein 3 2 2
MIRT566827 MAP3K7 mitogen-activated protein kinase kinase kinase 7 2 2
MIRT571236 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT571424 RIF1 replication timing regulatory factor 1 2 2
MIRT571637 SKI SKI proto-oncogene 2 2
MIRT571836 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT571962 KIF5B kinesin family member 5B 2 2
MIRT572104 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT572183 CDK6 cyclin dependent kinase 6 2 2
MIRT572720 RBL1 RB transcriptional corepressor like 1 2 2
MIRT574589 N4BP1 NEDD4 binding protein 1 2 2
MIRT575878 Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2 3
MIRT609979 HERPUD2 HERPUD family member 2 2 2
MIRT612932 GPRIN3 GPRIN family member 3 2 2
MIRT614327 C1orf220 chromosome 1 open reading frame 220 2 2
MIRT614694 TRAK1 trafficking kinesin protein 1 2 2
MIRT618328 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT618456 ZFP30 ZFP30 zinc finger protein 2 4
MIRT621135 EMC7 ER membrane protein complex subunit 7 2 4
MIRT622878 PDE12 phosphodiesterase 12 2 4
MIRT631163 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT632793 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT636731 AFAP1 actin filament associated protein 1 2 2
MIRT649297 IRF8 interferon regulatory factor 8 2 2
MIRT650955 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT653267 SOGA3 SOGA family member 3 2 2
MIRT654665 PSMG1 proteasome assembly chaperone 1 2 2
MIRT656180 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT659252 CUL3 cullin 3 2 2
MIRT663826 NLRP12 NLR family pyrin domain containing 12 2 4
MIRT676632 CSNK1E casein kinase 1 epsilon 2 2
MIRT679503 ZNF106 zinc finger protein 106 2 2
MIRT680978 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682272 RS1 retinoschisin 1 2 2
MIRT682421 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT682510 GLP2R glucagon like peptide 2 receptor 2 2
MIRT693926 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT700660 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT700740 PLEKHA8 pleckstrin homology domain containing A8 2 2
MIRT702871 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT703192 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT704453 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT704709 CHEK1 checkpoint kinase 1 2 2
MIRT706164 CASK calcium/calmodulin dependent serine protein kinase 2 3
MIRT713334 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT713416 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT716300 PAX1 paired box 1 2 2
MIRT717394 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT718453 BTNL9 butyrophilin like 9 2 2
MIRT718728 VWA9 integrator complex subunit 14 2 2
MIRT719029 SHROOM3 shroom family member 3 2 2
MIRT720367 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT723120 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT733741 EGFR epidermal growth factor receptor 4 0
MIRT734281 HIF1A hypoxia inducible factor 1 alpha subunit 3 0
MIRT735934 EYA3 EYA transcriptional coactivator and phosphatase 3 3 0
MIRT755830 IGF1 insulin like growth factor 1 5 1
MIRT755831 BCL2 BCL2, apoptosis regulator 4 1
MIRT755832 CDK2 cyclin dependent kinase 2 4 1
MIRT755833 BAX BCL2 associated X, apoptosis regulator 4 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-646 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-miR-646 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-646 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM43)
hsa-miR-646 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-646 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-646 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-646 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-646 Cisplatin 5460033 NSC119875 approved sensitive cell line (H460)

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