miRTarBase - #MIRT188656


—
pre-miRNA Information
pre-miRNA hsa-mir-3689a   
Genomic Coordinates chr9: 134849487 - 134849564
Description Homo sapiens miR-3689a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3689a-5p
Sequence 10| UGUGAUAUCAUGGUUCCUGGGA |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs866098973 7 dbSNP
rs1203092136 8 dbSNP
rs1275806724 10 dbSNP
rs1264215348 13 dbSNP
rs1203436967 16 dbSNP
rs1170643534 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FAM76A   
Synonyms -
Description family with sequence similarity 76 member A
Transcript NM_001143912   
Other Transcripts NM_001143913 , NM_001143914 , NM_001143915 , NM_152660   
Expression
Putative miRNA Targets on FAM76A
3'UTR of FAM76A
(miRNA target sites are highlighted)		 
>FAM76A|NM_001143912|3'UTR
   1 CAGACCTCAAGGAGGCTCCCTAGCAACAGCAAATGGAGTTGTCCAGGGTTAGGGTTGGAGACCTGGCTGTTCTGTGGGAA
  81 TTGCAAGCTTTCTTAAGAAATCTCTATTTTATTACAGTTATCCTTCTTTGTGCGATTGCAGTGGGCTGAATGGAAACACC
 161 TGGTTTGTGCTGTGTTAGACTGCATGCTTGAGTGTTTGGGATTTCAAGCTCGCTCTCTTTCTCTCACTATTAGGACTTTT
 241 CTTTTTCTTCTTCCTCTTCTCTCTATTTTGGTTCTATTCTTTTTTTTTCTTTTTTCTTTTTTTTTTTTTTTTTTTTTTTG
 321 TGGTGGTCACTGCTCAGTGTAATGTGCAGAATGATTTGTTTTTTGTTTTTTTTTTTTTTTTTGGTCCTTCATTGCATCCT
 401 GCCATACCCATGAGCAAACAGTTTGGCATTAATTATATATCACTGCCACCCTCTGAACTTTGAAAACTGCCATCTTCAGA
 481 CTTGGTATAATGGAAGAGGCTTTCTCTCTCCAATAAACCTTTTGCTTCAGGGTATACTCTTCGGTTTTTTTCCAGATGTA
 561 TTATGTATGAACTTTGTACTATGTATAGCCAGAGTTTTATTTATTTTTTAAAAAAGAAACTTTTTCTTGATAAAGGAATA
 641 ATGGTGGTCTAGCTAGTTCTTGTAAAAGTGATGCCTCTTGAAAAAAAAACAGTCCTATTCACTAGCTTTTAGTAAAAGAA
 721 TCAGATCTTTTCTTTCTTGTTACCTTGGAGTCTTAAAAACTGATTGCTAAGGTGAAACAATTCAATGCATAAGTATGGAG
 801 CTAAGTGCCTTTTGGAGGATTTCTTGGAAGAGCATTTATGGAGATACTTAAGGGAGGTAGCAAAGATTTGAACCGTCTGT
 881 CTTTTTAAGTAAGGGCAGAAAGCAAGGTTGTCCAGGTTGTACTGGACACTTCTCTCCCCACCCCTTTCCTGATTGTTTTA
 961 TGTGATTGATTTTAAATTCTCACACTGCCACTTCTTTAAAAAATAAAATCCTTTATTTGCTTATATCAGTTGTCATACTG
1041 GGCTGCTGTCAGAGAATGTTTTTTTACATGAATGAACAGATTAAAAATGGAATAATATGGTCGGGTGCGGTGGCTCACGC
1121 CTGTAATACCAGCAATTTGGGAGGCCAAGGCGGGTGGATCATTTGAGGTTAGGAGTTTGAGACCATCCTGGCCAACATGG
1201 TAAAACCCCATCTGTACTAAAAAAATACAAAAATTAGCCGGGCCTGGTGGCATGCACCTGTAATCCCAGCTACCCAGGAG
1281 GCTGAGGCAGGAGAACTGCTCGAATCCCGGGAGGCAGAGGTTGCAATGAGCTGAAATCGCAACACTGCACTGCAGCCTGG
1361 GCAATGGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAGGAATAATATTTGAACTACAGAGCATTTTTGGGGTCAGCAT
1441 GAGCTGCTCTAGTAAGGACTCTTGAGTCTGGGAAAAGTGGTATCACTATACCTTCTCCCCACTCCTCACCCACCCGAGCC
1521 CATACACTCCCTGCTTTTCATGGATATGTATTGAAAACAGGTGCTTCTCAGAAGCACTTTGCCTCAACCAGAGTTATGTA
1601 TGCCCTGCCTATCTTCCCTTCTTAACCCTGTAGGAATATGGATTTACTTTTCCAGGAAAGGGGATAGATTTACATTTCTA
1681 GGCATACTCTCAGGTCCTCTATGTGATGTTTGTGAAAGGAATTAGGGTGTGTCATGTGTGCCATGAAACAACAAAACCAA
1761 CTACCCTAGAATCATTTATGCAGGGGGTACTAGAGTTAGAAATAATAATGAGGGCAGATAACATTTGTACCTCAGTCTAC
1841 CAAAAAATTATAGTACTAAATTTAACTTCTAGGCGTTTCCTGGAAGCAGATGCTCTATAATTTGTGATAGCATTCTCATA
1921 AATGGAGTCCTACACATAATTGGACAGAGATGTGGAAATGGTGGTTTCCTTCTGATAAGGGATACAGTGGACCATGTCGC
2001 TTATATATCACCCTACTAGGGGATATAATTTTCCCTTCTAAGCAAGGGAAATGGCAGTGCTAAATAGTTTTGTAAAGTTT
2081 TTGAATGAGAAGCTTTTAGGTAAAGATAAACTGTCATAATATTTTTCAGATGCATTTGCATTGACTATGGGAGAAAAATT
2161 AGGGGGAAATGACAGTCATGGTGTTTTTTTTTAATTTTAAGGACTGAAATTCTGTTACATGATGTATGACAATATAAAAA
2241 CATACTTAGTTTTATACTAAATCTTTTTTTAAGGTCTTGGCATTTAATATAAAGCAAATTCACACGTTTTCTAACTTTCC
2321 ATAAGTTCCAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aggGUC-CUUGGUAC--------UAUAGUGu 5'
             ||| |:||||||        ||||||| 
Target 5' ataCAGTGGACCATGTCGCTTATATATCACc 3'
 1982 - 2012 161.00 -19.10
2 
miRNA  3' aggGUCCUUGGUACUAUAGUGu 5'
             ||  ||::|| ||||||| 
Target 5' tggCATTAATTAT-ATATCACt 3'
 424 - 444 158.00 -9.30
3 
miRNA  3' agGGUCCUUGGUACUAUAGUGu 5'
            |::||||  :||:|||||| 
Target 5' gtCTGGGAAAAGTGGTATCACt 3'
 1466 - 1487 156.00 -22.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM9621413 1 COSMIC
COSN26504782 4 COSMIC
COSN30104497 49 COSMIC
COSN24920222 96 COSMIC
COSN28856727 110 COSMIC
COSN31567723 269 COSMIC
COSN31538167 304 COSMIC
COSN24344918 371 COSMIC
COSN31593690 373 COSMIC
COSN32062338 383 COSMIC
COSN24298281 396 COSMIC
COSN31485928 543 COSMIC
COSN26644831 544 COSMIC
COSN20094607 690 COSMIC
COSN16724064 773 COSMIC
COSN30165323 855 COSMIC
COSN31579817 930 COSMIC
COSN31555274 1045 COSMIC
COSN1102380 1530 COSMIC
COSN20090192 1746 COSMIC
COSN6032977 1795 COSMIC
COSN21016445 2042 COSMIC
COSN17219578 2144 COSMIC
COSN5370581 2443 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1232432661 8 dbSNP
rs1375343514 13 dbSNP
rs368709412 18 dbSNP
rs1484078041 28 dbSNP
rs1203168162 31 dbSNP
rs1292386651 36 dbSNP
rs1259868251 42 dbSNP
rs779356714 49 dbSNP
rs566098135 62 dbSNP
rs900676876 64 dbSNP
rs996335282 70 dbSNP
rs12134315 93 dbSNP
rs535209572 95 dbSNP
rs762027605 101 dbSNP
rs772177354 112 dbSNP
rs1250931373 114 dbSNP
rs975422961 118 dbSNP
rs1235093772 126 dbSNP
rs565148273 134 dbSNP
rs558097965 135 dbSNP
rs1011797376 143 dbSNP
rs1255803615 146 dbSNP
rs1476324353 155 dbSNP
rs933998958 168 dbSNP
rs1410548454 178 dbSNP
rs961112824 184 dbSNP
rs140351910 194 dbSNP
rs531655660 198 dbSNP
rs945873640 200 dbSNP
rs556911380 206 dbSNP
rs575178012 208 dbSNP
rs1442755951 212 dbSNP
rs904253531 213 dbSNP
rs969875187 216 dbSNP
rs1416295985 218 dbSNP
rs1293494873 224 dbSNP
rs573702512 226 dbSNP
rs1274424300 242 dbSNP
rs1308601230 245 dbSNP
rs1210736521 251 dbSNP
rs1255913088 254 dbSNP
rs1394207808 258 dbSNP
rs1189007352 259 dbSNP
rs1486842051 259 dbSNP
rs1437709412 266 dbSNP
rs1295635320 272 dbSNP
rs1188365988 277 dbSNP
rs1368868445 277 dbSNP
rs1325501602 280 dbSNP
rs1334464233 280 dbSNP
rs1430355892 280 dbSNP
rs1436344970 280 dbSNP
rs371827457 280 dbSNP
rs1428130562 281 dbSNP
rs772746609 281 dbSNP
rs1214174028 282 dbSNP
rs1271455757 283 dbSNP
rs979957751 284 dbSNP
rs925849194 287 dbSNP
rs1212061328 290 dbSNP
rs1350575419 290 dbSNP
rs375167463 290 dbSNP
rs58597359 294 dbSNP
rs1320031342 296 dbSNP
rs1172948335 297 dbSNP
rs1193004272 297 dbSNP
rs1319850958 297 dbSNP
rs1383916993 297 dbSNP
rs1393175436 297 dbSNP
rs1427100531 297 dbSNP
rs1453837218 297 dbSNP
rs1455485362 297 dbSNP
rs200943332 297 dbSNP
rs34757636 297 dbSNP
rs397864149 297 dbSNP
rs935918603 297 dbSNP
rs59299410 300 dbSNP
rs1388823845 302 dbSNP
rs1300555541 303 dbSNP
rs1439510031 303 dbSNP
rs1214574230 304 dbSNP
rs544111304 304 dbSNP
rs978262327 305 dbSNP
rs988807051 306 dbSNP
rs1207158579 309 dbSNP
rs1220406313 314 dbSNP
rs1285211764 314 dbSNP
rs1468139335 316 dbSNP
rs1271124374 317 dbSNP
rs1321046007 318 dbSNP
rs1211912010 319 dbSNP
rs1254893269 320 dbSNP
rs1420605534 320 dbSNP
rs1361734862 321 dbSNP
rs1297279846 322 dbSNP
rs1883162 322 dbSNP
rs1248218130 323 dbSNP
rs2871986 325 dbSNP
rs1484714550 326 dbSNP
rs1185535742 327 dbSNP
rs1468408776 329 dbSNP
rs1160003975 331 dbSNP
rs1263305122 332 dbSNP
rs1478484998 340 dbSNP
rs1162163074 342 dbSNP
rs1417844109 343 dbSNP
rs1412272795 344 dbSNP
rs1406435367 345 dbSNP
rs1460534266 349 dbSNP
rs78367728 350 dbSNP
rs1323350025 353 dbSNP
rs1167396730 354 dbSNP
rs1343763232 355 dbSNP
rs1430305882 357 dbSNP
rs1387906795 359 dbSNP
rs78838779 359 dbSNP
rs1423474148 363 dbSNP
rs1342455143 364 dbSNP
rs913229440 364 dbSNP
rs377580420 365 dbSNP
rs1183734629 366 dbSNP
rs1252228463 366 dbSNP
rs1334446832 366 dbSNP
rs1435949796 366 dbSNP
rs202213914 366 dbSNP
rs74422309 366 dbSNP
rs1474690577 369 dbSNP
rs1162323705 370 dbSNP
rs201994909 370 dbSNP
rs1167901751 371 dbSNP
rs1292736396 371 dbSNP
rs200014745 372 dbSNP
rs541717898 372 dbSNP
rs200267993 373 dbSNP
rs1355165815 374 dbSNP
rs1413214125 375 dbSNP
rs944776148 379 dbSNP
rs1228786893 383 dbSNP
rs1377873327 384 dbSNP
rs60279432 384 dbSNP
rs1226804010 385 dbSNP
rs28689084 386 dbSNP
rs1314865577 387 dbSNP
rs1215467117 388 dbSNP
rs1286367400 391 dbSNP
rs1489057473 392 dbSNP
rs1185218478 395 dbSNP
rs1197438336 403 dbSNP
rs1275151881 408 dbSNP
rs1185433891 413 dbSNP
rs59402290 415 dbSNP
rs1259157161 421 dbSNP
rs1423969125 421 dbSNP
rs1256152796 426 dbSNP
rs1370802238 440 dbSNP
rs1463997843 452 dbSNP
rs1169756492 453 dbSNP
rs1473429983 474 dbSNP
rs1375295300 478 dbSNP
rs1184057062 479 dbSNP
rs1001667726 492 dbSNP
rs572299281 499 dbSNP
rs895449618 500 dbSNP
rs900636328 502 dbSNP
rs1159627394 505 dbSNP
rs1293555764 506 dbSNP
rs1013932956 521 dbSNP
rs541197072 532 dbSNP
rs1224599872 533 dbSNP
rs564306940 534 dbSNP
rs932137218 535 dbSNP
rs1025900077 537 dbSNP
rs1346950326 539 dbSNP
rs1208479108 540 dbSNP
rs760719463 543 dbSNP
rs3813801 544 dbSNP
rs1017544783 545 dbSNP
rs1049230907 546 dbSNP
rs1448701378 566 dbSNP
rs964265256 568 dbSNP
rs554098345 569 dbSNP
rs975866726 576 dbSNP
rs766340954 579 dbSNP
rs1453383701 580 dbSNP
rs543564387 582 dbSNP
rs1015225589 583 dbSNP
rs1387315280 584 dbSNP
rs1239228130 588 dbSNP
rs1309682708 596 dbSNP
rs955370732 601 dbSNP
rs988134284 606 dbSNP
rs913133875 610 dbSNP
rs945997274 611 dbSNP
rs1013960372 613 dbSNP
rs71642213 617 dbSNP
rs1208224991 621 dbSNP
rs1303162143 631 dbSNP
rs563225571 637 dbSNP
rs528888558 639 dbSNP
rs1237925599 641 dbSNP
rs548742683 642 dbSNP
rs1024455476 650 dbSNP
rs1442434299 662 dbSNP
rs1208816358 673 dbSNP
rs1212863961 679 dbSNP
rs1193410381 681 dbSNP
rs397979755 681 dbSNP
rs60888738 681 dbSNP
rs201404325 682 dbSNP
rs1426366742 686 dbSNP
rs1418860578 689 dbSNP
rs925753703 695 dbSNP
rs1439610078 698 dbSNP
rs1179712266 701 dbSNP
rs753731120 702 dbSNP
rs969824695 715 dbSNP
rs979903950 716 dbSNP
rs1438684450 725 dbSNP
rs1295185080 728 dbSNP
rs759343653 733 dbSNP
rs191362864 740 dbSNP
rs776597711 745 dbSNP
rs1173198894 751 dbSNP
rs1228575858 754 dbSNP
rs1272049979 755 dbSNP
rs957235510 756 dbSNP
rs183656211 772 dbSNP
rs1247783380 786 dbSNP
rs1480557806 789 dbSNP
rs1416179939 790 dbSNP
rs765020049 793 dbSNP
rs1473053935 797 dbSNP
rs551918503 806 dbSNP
rs372279760 808 dbSNP
rs1445912020 819 dbSNP
rs1046786311 825 dbSNP
rs1165502024 828 dbSNP
rs921989918 830 dbSNP
rs1461385081 833 dbSNP
rs1296263297 835 dbSNP
rs1219127153 840 dbSNP
rs571530671 848 dbSNP
rs932083838 851 dbSNP
rs1378772958 853 dbSNP
rs187246804 870 dbSNP
rs1017202907 875 dbSNP
rs964528682 876 dbSNP
rs550669595 884 dbSNP
rs1220513087 885 dbSNP
rs1029701564 890 dbSNP
rs1270249428 894 dbSNP
rs1457742019 901 dbSNP
rs1037018065 902 dbSNP
rs567461973 903 dbSNP
rs1277275288 914 dbSNP
rs1483568639 928 dbSNP
rs1199776807 929 dbSNP
rs1187583949 930 dbSNP
rs896757112 937 dbSNP
rs1240442595 945 dbSNP
rs1467378637 959 dbSNP
rs1198432166 960 dbSNP
rs955480593 963 dbSNP
rs1182550772 986 dbSNP
rs1418835092 988 dbSNP
rs192524571 1012 dbSNP
rs752434064 1014 dbSNP
rs541026619 1017 dbSNP
rs1378498002 1019 dbSNP
rs1014325349 1020 dbSNP
rs1479114801 1021 dbSNP
rs553121806 1041 dbSNP
rs1284297517 1042 dbSNP
rs1360634316 1050 dbSNP
rs1045439548 1057 dbSNP
rs1166267357 1058 dbSNP
rs1300440175 1059 dbSNP
rs138139515 1060 dbSNP
rs1210624828 1061 dbSNP
rs913876891 1066 dbSNP
rs1278585292 1068 dbSNP
rs1444366280 1069 dbSNP
rs1211061511 1072 dbSNP
rs763253518 1078 dbSNP
rs1331886501 1083 dbSNP
rs758129603 1103 dbSNP
rs1438524995 1104 dbSNP
rs1186661941 1106 dbSNP
rs1032814244 1108 dbSNP
rs968040375 1109 dbSNP
rs759706638 1110 dbSNP
rs957426894 1119 dbSNP
rs979047086 1124 dbSNP
rs925900361 1126 dbSNP
rs937162965 1134 dbSNP
rs1316694846 1141 dbSNP
rs1055671005 1152 dbSNP
rs916982678 1153 dbSNP
rs949809159 1179 dbSNP
rs1219801894 1195 dbSNP
rs976463873 1203 dbSNP
rs1046858613 1207 dbSNP
rs1301760270 1210 dbSNP
rs1260481520 1217 dbSNP
rs765446847 1219 dbSNP
rs886748796 1219 dbSNP
rs867902430 1221 dbSNP
rs561640028 1229 dbSNP
rs995640691 1229 dbSNP
rs1210672708 1231 dbSNP
rs900123512 1236 dbSNP
rs777270957 1240 dbSNP
rs751156187 1241 dbSNP
rs1029816050 1243 dbSNP
rs909339722 1253 dbSNP
rs185312813 1254 dbSNP
rs1009583546 1266 dbSNP
rs1020998123 1282 dbSNP
rs968419284 1283 dbSNP
rs1455281361 1289 dbSNP
rs1160776548 1291 dbSNP
rs1388700582 1299 dbSNP
rs376304703 1302 dbSNP
rs979490520 1303 dbSNP
rs370731107 1309 dbSNP
rs780728841 1310 dbSNP
rs1036560568 1314 dbSNP
rs958672674 1326 dbSNP
rs114586119 1327 dbSNP
rs1172900284 1339 dbSNP
rs1268897365 1340 dbSNP
rs917056703 1344 dbSNP
rs1265167730 1352 dbSNP
rs949681533 1354 dbSNP
rs1425759350 1359 dbSNP
rs1232045341 1369 dbSNP
rs1471435331 1380 dbSNP
rs1314509364 1383 dbSNP
rs1045386122 1384 dbSNP
rs1164734944 1384 dbSNP
rs1328623854 1384 dbSNP
rs755947488 1384 dbSNP
rs975752495 1384 dbSNP
rs79541154 1385 dbSNP
rs1348989561 1386 dbSNP
rs1162477198 1387 dbSNP
rs905535747 1388 dbSNP
rs1289213308 1393 dbSNP
rs1354962755 1394 dbSNP
rs1242716979 1395 dbSNP
rs1267228979 1397 dbSNP
rs1358409211 1400 dbSNP
rs949880877 1401 dbSNP
rs1286422079 1402 dbSNP
rs1315722442 1403 dbSNP
rs1339286644 1405 dbSNP
rs1001238074 1407 dbSNP
rs1481948946 1416 dbSNP
rs142468273 1421 dbSNP
rs892912057 1429 dbSNP
rs1354155041 1430 dbSNP
rs908328897 1439 dbSNP
rs1184823537 1442 dbSNP
rs1369637704 1443 dbSNP
rs1010473470 1445 dbSNP
rs1167810863 1450 dbSNP
rs941023809 1489 dbSNP
rs867540019 1490 dbSNP
rs1244644949 1491 dbSNP
rs11247680 1492 dbSNP
rs900071778 1495 dbSNP
rs932891768 1498 dbSNP
rs146504155 1504 dbSNP
rs891255694 1510 dbSNP
rs1009699475 1516 dbSNP
rs1339907760 1517 dbSNP
rs1020986839 1520 dbSNP
rs1195995719 1522 dbSNP
rs1198344663 1524 dbSNP
rs1485151287 1524 dbSNP
rs1257704853 1528 dbSNP
rs1442489436 1529 dbSNP
rs903975588 1530 dbSNP
rs1028900845 1532 dbSNP
rs1001254947 1541 dbSNP
rs1422020841 1553 dbSNP
rs953376869 1566 dbSNP
rs559103979 1571 dbSNP
rs1394836713 1572 dbSNP
rs1464769372 1575 dbSNP
rs959647924 1576 dbSNP
rs11247681 1577 dbSNP
rs866476078 1578 dbSNP
rs972618906 1578 dbSNP
rs1024228928 1588 dbSNP
rs189986649 1589 dbSNP
rs982653732 1591 dbSNP
rs1359571160 1595 dbSNP
rs908272393 1599 dbSNP
rs139115556 1602 dbSNP
rs936974124 1605 dbSNP
rs1483338913 1610 dbSNP
rs974243868 1611 dbSNP
rs1054152342 1612 dbSNP
rs531000445 1614 dbSNP
rs1313980549 1628 dbSNP
rs1431791941 1647 dbSNP
rs550810305 1649 dbSNP
rs1178616218 1651 dbSNP
rs1378431570 1657 dbSNP
rs945816385 1669 dbSNP
rs193284333 1683 dbSNP
rs563117226 1685 dbSNP
rs536379826 1689 dbSNP
rs766968686 1704 dbSNP
rs772383540 1706 dbSNP
rs997344320 1712 dbSNP
rs1321133300 1713 dbSNP
rs1308958894 1730 dbSNP
rs1051253275 1736 dbSNP
rs1028848439 1761 dbSNP
rs889060401 1767 dbSNP
rs1384872363 1771 dbSNP
rs891412481 1775 dbSNP
rs1006148498 1777 dbSNP
rs749901307 1781 dbSNP
rs1265741484 1787 dbSNP
rs1016286122 1794 dbSNP
rs1219025223 1800 dbSNP
rs1278312994 1807 dbSNP
rs1487755001 1811 dbSNP
rs755735361 1837 dbSNP
rs1199811677 1849 dbSNP
rs1472417476 1862 dbSNP
rs1180245429 1873 dbSNP
rs1414362226 1875 dbSNP
rs945544854 1876 dbSNP
rs1425474821 1879 dbSNP
rs779690643 1880 dbSNP
rs1176599917 1889 dbSNP
rs970885211 1896 dbSNP
rs143231028 1902 dbSNP
rs1000927266 1905 dbSNP
rs1055634818 1916 dbSNP
rs1286057101 1923 dbSNP
rs1351889949 1929 dbSNP
rs1160017756 1930 dbSNP
rs1288480696 1934 dbSNP
rs566773535 1937 dbSNP
rs12059293 1944 dbSNP
rs1302902017 1958 dbSNP
rs1482929317 1959 dbSNP
rs1203349382 1963 dbSNP
rs1254256987 1964 dbSNP
rs914249559 1966 dbSNP
rs77933424 1976 dbSNP
rs1411656840 1980 dbSNP
rs1166827022 1982 dbSNP
rs971329287 1982 dbSNP
rs1428887624 1983 dbSNP
rs1004037780 2000 dbSNP
rs1372060534 2002 dbSNP
rs1331136436 2004 dbSNP
rs184653045 2010 dbSNP
rs770944254 2018 dbSNP
rs1015400506 2022 dbSNP
rs962882103 2035 dbSNP
rs1242606895 2042 dbSNP
rs1314043786 2043 dbSNP
rs1341997198 2045 dbSNP
rs537238223 2046 dbSNP
rs1301438366 2057 dbSNP
rs1277161521 2068 dbSNP
rs1483516959 2068 dbSNP
rs889009791 2071 dbSNP
rs1311826535 2072 dbSNP
rs1484269901 2081 dbSNP
rs1234132638 2112 dbSNP
rs1016644978 2122 dbSNP
rs973811296 2130 dbSNP
rs1448754899 2134 dbSNP
rs897818521 2136 dbSNP
rs993947617 2148 dbSNP
rs1410227885 2150 dbSNP
rs1257815289 2155 dbSNP
rs921022212 2159 dbSNP
rs189200704 2160 dbSNP
rs1356984797 2161 dbSNP
rs1449598805 2166 dbSNP
rs776558321 2173 dbSNP
rs1196622173 2178 dbSNP
rs573647699 2179 dbSNP
rs1365140327 2181 dbSNP
rs1433465329 2182 dbSNP
rs1002346838 2184 dbSNP
rs1033848582 2184 dbSNP
rs879302278 2187 dbSNP
rs866148767 2194 dbSNP
rs1314096619 2196 dbSNP
rs958240485 2205 dbSNP
rs1247443086 2217 dbSNP
rs989737686 2220 dbSNP
rs1043044863 2223 dbSNP
rs542382298 2233 dbSNP
rs1249736963 2243 dbSNP
rs925449680 2254 dbSNP
rs1422691021 2257 dbSNP
rs914176391 2260 dbSNP
rs1171717398 2264 dbSNP
rs1422624187 2264 dbSNP
rs1432213116 2270 dbSNP
rs936836123 2277 dbSNP
rs559258119 2287 dbSNP
rs1055179290 2292 dbSNP
rs1464540781 2304 dbSNP
rs759587799 2306 dbSNP
rs967051822 2307 dbSNP
rs1013576824 2311 dbSNP
rs1273404552 2319 dbSNP
rs1370031025 2321 dbSNP
rs748892383 2322 dbSNP
rs1292137542 2327 dbSNP
rs1267635495 2331 dbSNP
rs1327162151 2332 dbSNP
rs923015657 2338 dbSNP
rs1269951880 2348 dbSNP
rs1447439553 2363 dbSNP
rs1367235093 2373 dbSNP
rs1244713320 2381 dbSNP
rs1478833056 2388 dbSNP
rs1387537344 2392 dbSNP
rs1199656855 2397 dbSNP
rs752469549 2415 dbSNP
rs1455200586 2419 dbSNP
rs1303523152 2426 dbSNP
rs1160651692 2428 dbSNP
rs886454391 2429 dbSNP
rs1405240025 2437 dbSNP
rs1316077200 2445 dbSNP
rs531994078 2453 dbSNP
rs775406653 2457 dbSNP
rs1004109880 2472 dbSNP
rs548919308 2485 dbSNP
rs1200356695 2490 dbSNP
rs1348791622 2500 dbSNP
rs1015930347 2501 dbSNP
rs962541537 2507 dbSNP
rs1289021682 2509 dbSNP
rs995780640 2513 dbSNP
rs1028070050 2525 dbSNP
rs1287515477 2535 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions EF3D-AGO2
Disease MIMAT0018117
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020021. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_152660 | 3UTR | AAAUGGAGUCCUACACAUAAUUGGACAGAGAUGUGGAAAUGGUGGUUUCCUUCUGAUAAGGGAUACAGUGGACCAUGUCGCUUAUAUAUCACCCUACUAGGGGAUAUAAUUUUCCCUUCUAAGCAAGGGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_152660 | 3UTR | CAGAGAUGUGGAAAUGGUGGUUUCCUUCUGAUAAGGGAUACAGUGGACCAUGUCGCUUAUAUAUCACCCUACUAGGGGAUAUAAUUUUCCCUUCUAAGCAAGGGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_152660 | 3UTR | AUAAAUGGAGUCCUACACAUAAUUGGACAGAGAUGUGGAAAUGGUGGUUUCCUUCUGAUAAGGGAUACAGUGGACCAUGUCGCUUAUAUAUCACCCUACUAGGGGAUAUAAUUUUCCCUUCUAAGCAAGGGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_152660 | 3UTR | GGACAGAGAUGUGGAAAUGGUGGUUUCCUUCUGAUAAGGGAUACAGUGGACCAUGUCGCUUAUAUAUCACCCUACUAGGGGAUAUAAUUUUCCCUUCUAAGCAAGGGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_152660 | 3UTR | UUUCCUUCUGAUAAGGGAUACAGUGGACCAUGUCGCUUAUAUAUCACCCUACUAGGGGAUAUAAUUUUCCCUUCUAAGCAAGGGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001143915 | 3UTR | UCUCAUAAAUGGAGUCCUACACAUAAUUGGACAGAGAUGUGGAAAUGGUGGUUUCCUUCUGAUAAGGGAUACAGUGGACCAUGUCGCUUAUAUAUCACCCUACUAGGGGAUAUAAUUUUCCCUUCUAAGCAAGGGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1020021
Method / RBP PAR-CLIP / AGO2
Cell line / Condition EF3D-AGO2 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000373954.6 | 3UTR | UUGGCAUUAAUUAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
45 hsa-miR-3689a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT112230 MDM4 MDM4, p53 regulator 2 2
MIRT188656 FAM76A family with sequence similarity 76 member A 2 2
MIRT200911 ZNF264 zinc finger protein 264 2 4
MIRT210595 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT299207 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT317524 SLC39A7 solute carrier family 39 member 7 2 2
MIRT355849 SGMS2 sphingomyelin synthase 2 2 4
MIRT443052 THRB thyroid hormone receptor beta 2 2
MIRT446631 SDC3 syndecan 3 2 2
MIRT449409 TRIM5 tripartite motif containing 5 2 2
MIRT463561 ZBTB39 zinc finger and BTB domain containing 39 2 6
MIRT465704 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT472688 MYCBP MYC binding protein 2 4
MIRT493287 LNPEP leucyl and cystinyl aminopeptidase 2 2
MIRT499338 RAB25 RAB25, member RAS oncogene family 2 2
MIRT501723 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT507977 BCL2L13 BCL2 like 13 2 4
MIRT511811 HDGF heparin binding growth factor 2 6
MIRT516711 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 2 4
MIRT527853 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT531286 SLC7A7 solute carrier family 7 member 7 2 2
MIRT531894 INVS inversin 2 8
MIRT536807 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT537807 EFNB2 ephrin B2 2 4
MIRT544335 LPGAT1 lysophosphatidylglycerol acyltransferase 1 2 2
MIRT547142 PGM3 phosphoglucomutase 3 2 2
MIRT547429 MED4 mediator complex subunit 4 2 2
MIRT563354 ZNF181 zinc finger protein 181 2 2
MIRT564849 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566426 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 2
MIRT572512 KIAA0232 KIAA0232 2 2
MIRT574682 HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2 2
MIRT608820 ONECUT3 one cut homeobox 3 2 6
MIRT608886 CLIC6 chloride intracellular channel 6 2 2
MIRT608959 GIMAP1 GTPase, IMAP family member 1 2 4
MIRT609012 HPS3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 2 2
MIRT641431 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT661841 ZNF587B zinc finger protein 587B 2 2
MIRT690651 RPF2 ribosome production factor 2 homolog 2 2
MIRT704619 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708714 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT710663 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 2
MIRT711260 TPCN2 two pore segment channel 2 2 2
MIRT714649 FSTL1 follistatin like 1 2 2
MIRT718518 COL19A1 collagen type XIX alpha 1 chain 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3689a Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-3689a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-3689a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-3689a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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