miRTarBase - #MIRT188776


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pre-miRNA Information
pre-miRNA hsa-mir-4464   
Genomic Coordinates chr6: 90312742 - 90312833
Description Homo sapiens miR-4464 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4464
Sequence 12| AAGGUUUGGAUAGAUGCAAUA |32
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 6 + 90312764 29233923 MiREDiBase
A-to-I 14 6 + 90312766 29233923 MiREDiBase
A-to-I 19 6 + 90312771 29233923 MiREDiBase
A-to-I 21 6 + 90312773 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1240632245 2 dbSNP
rs34899210 2 dbSNP
rs1003034046 13 dbSNP
rs1475351324 14 dbSNP
rs1257582329 17 dbSNP
rs1193587810 20 dbSNP
Putative Targets

Gene Information
Gene Symbol SESN2   
Synonyms HI95, SES2, SEST2
Description sestrin 2
Transcript NM_031459   
Expression
Putative miRNA Targets on SESN2
3'UTR of SESN2
(miRNA target sites are highlighted)		 
>SESN2|NM_031459|3'UTR
   1 CTCCTGAGCAGGACCTGGGCCCGGTTCAGCTCCCCACAAGGACTTCTCTGTCTGGAGACAGCCCCAGACCCTTTTGTGTC
  81 CCATGCCCACCCTCCCCACGCTGCAGTGGGCTTGTGTGTGATGTGCAGTCCCGAAGCCACACCCTCCCTTTTCCTCACTG
 161 GAATGGACAGTTCATTGCACTGACTCTGGGATCTCAGCCCTGCTCCTGGGAGCTGGAAGAGCACTTGGAGATCCTAAGGG
 241 ACCACACCCTTCCTCCTTCCCCTGCCCACAGAGGCAGAGGGCACAGGAAAGAAGCCGGGCCAAGCTCGGAATTAATGTGC
 321 CACAAGTGTTGTGGCCTTCCTGAACTGGGAAGTCCCTGGCTGGCCCCCGGGGGAGAGGGGCAAATGCCTCCGGGACTGAC
 401 ACTCCAGGCAGCTTTGCCTTCTCTCCCCTGTCATTTCCAGATTTCATTACCTCCTACTTGCCATTCACCCATCAATGTGA
 481 AAGTCAGGGTCACAGCTGGTCTGTGTGTCCAGTTCCCTAAAAGCCTGTTCTGTTGGGCAGCCTGAGGCTGTTGCCCGAAT
 561 CCTAGTTCAGTTTTTTGACTTCCTTTGCCCTTTTTCCCTTTTCTCCATGCTTAATGGTGTGAGGCGTCAGGAGAGAGGCC
 641 AAGTACATAAAAAAAAAAAAAGCAGATTATCTCTAGAGAGTTTGAGCCTTTGCTGGTCACATTGCCTTCTGAAGAGGAGG
 721 GAGTATTAGATTATAAATCCTCTTTATTTTGGTCCTTTATGCTTGAGGTTCCAACCTGGAGCCACAGTGTGTGAGAGGAG
 801 GAGGAGAGGGAGAATTCTGTTCTCCCAGAGCTGCACCTGCCTCGCAGAGGCCAGCACCCCACTCTCCTGCCTCCAGTGGC
 881 CCTGCCGCAGATGTCTCCCAAAAAGTTGAGCCTTTCTAGATGGCTTAGGTGGCACCATGGCTCAGCAGGAGGGGCGGGAG
 961 GCACCAGGGTTCTTGTTTGGACCCTGCCCCTGGGCCATGGCCAGGTGACCATGGCTACATTGCCAAACCTCTGACTGCCA
1041 CAGCTGCAGACTGAGAGGGTGGGTCTGAGTCCCCACAATGTCTGAAGCTGCCCCTGGGATTCTCAGGCCAACCTGCCAAC
1121 AGCAAGCGGATTTTCTTGCAAGATCAGGGACCCCATTTCTGCAGCCAGTGTCTCCTGGGTGCCTTCTGAGGACTCCCACC
1201 CCCATCCCAGTATCTCATCTGTCCCCTCTCCTGGGGCTTAAGTGGGTTGCTTCCAGGCAGAAGCAGCCAAGGACCGATTC
1281 CAGGCACTTTCTGTAGCAAATGACTGTGAATTACGACTTCTCTTGCCCTTCTTCTAGCAGTCTGTGCCTCCTCTCTGACC
1361 AGTTTGGAGGGCACTGAAGAAAGGCAAGGGCCGTGCTGCTGCTGGGCGGGGCAGGAGAGGAGCCTGGCCAGTGTGCCACA
1441 TTAAATACCCGTGCAGGCGCGGAGAAGCAACCGGCACCCCCTTCCGGCCTGAAAGCCCTCCCTGCAAGAAGGTGTGCAGG
1521 AGAGAAGAGGCCCCGGCATGGGGATCTGGGTTCTAGAGGGCATGTGATGACTGTAAATGTTCACTGGGTGGGTAGGGAGT
1601 GGTATCCAGTGTTCAAGTGCAGAAATCTTTGGCTTTGCTACCAGTTCCATATGATGAGAAATAAACGTTCGCTGAGGTTT
1681 TGTTTCATAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auaACGUAGAUAGGUUUGGAa 5'
             | ||| |: |||||||| 
Target 5' ggcTACAT-TG-CCAAACCTc 3'
 1013 - 1031 152.00 -14.10
2 
miRNA  3' auaACGUAGAU--AGGUUUGGAa 5'
             ||| |: |  |:| ||||| 
Target 5' ttaTGC-TTGAGGTTCCAACCTg 3'
 757 - 778 119.00 -8.50
3 
miRNA  3' auAACGU-AGA-UAGGUUUGGAa 5'
            | | | ||| |  | ||||| 
Target 5' ccTGGGATTCTCAGGCCAACCTg 3'
 1093 - 1115 115.00 -10.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26636402 20 COSMIC
COSN30508915 24 COSMIC
COSN30485371 95 COSMIC
COSN30027538 131 COSMIC
COSN5740424 188 COSMIC
COSN24325465 571 COSMIC
COSN1102439 662 COSMIC
COSN20094622 662 COSMIC
COSN17181560 787 COSMIC
COSN29796172 1091 COSMIC
COSN28202125 1180 COSMIC
COSN27800418 1536 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769395715 4 dbSNP
rs547652634 5 dbSNP
rs370925800 10 dbSNP
rs766661062 18 dbSNP
rs757483688 23 dbSNP
rs375396916 24 dbSNP
rs767831374 30 dbSNP
rs752886912 31 dbSNP
rs758274242 32 dbSNP
rs1179983876 35 dbSNP
rs1257212704 38 dbSNP
rs756219286 40 dbSNP
rs777781076 41 dbSNP
rs1187940130 43 dbSNP
rs1261574951 44 dbSNP
rs779852360 46 dbSNP
rs961534163 49 dbSNP
rs1168889678 51 dbSNP
rs992991731 53 dbSNP
rs917436163 57 dbSNP
rs949163716 60 dbSNP
rs980393843 62 dbSNP
rs1291423893 68 dbSNP
rs1288225559 72 dbSNP
rs926281645 77 dbSNP
rs1401645582 79 dbSNP
rs950275639 81 dbSNP
rs936351159 87 dbSNP
rs1344520352 90 dbSNP
rs140893776 92 dbSNP
rs1221299098 100 dbSNP
rs533051045 101 dbSNP
rs1248383828 103 dbSNP
rs1053668986 115 dbSNP
rs892382959 119 dbSNP
rs1466119284 126 dbSNP
rs1181555670 133 dbSNP
rs549585881 134 dbSNP
rs1264304457 141 dbSNP
rs1480268657 147 dbSNP
rs116173499 165 dbSNP
rs887362317 174 dbSNP
rs1427454250 180 dbSNP
rs945181719 182 dbSNP
rs1040938240 190 dbSNP
rs1383565290 196 dbSNP
rs1421413970 198 dbSNP
rs1298653347 212 dbSNP
rs190182009 226 dbSNP
rs1402812583 232 dbSNP
rs1294929594 244 dbSNP
rs1367817449 257 dbSNP
rs1163844029 260 dbSNP
rs901239945 262 dbSNP
rs1038462090 272 dbSNP
rs899562098 290 dbSNP
rs1242940450 296 dbSNP
rs1399455413 297 dbSNP
rs996962059 298 dbSNP
rs17163103 304 dbSNP
rs1029488419 308 dbSNP
rs1488919449 321 dbSNP
rs1176733916 325 dbSNP
rs1236429357 346 dbSNP
rs1441532615 348 dbSNP
rs890993831 356 dbSNP
rs1437679758 360 dbSNP
rs1009359325 363 dbSNP
rs781326789 369 dbSNP
rs566076103 370 dbSNP
rs1005974810 371 dbSNP
rs1378451835 372 dbSNP
rs1053101 374 dbSNP
rs534973944 381 dbSNP
rs1227015424 385 dbSNP
rs1015839231 386 dbSNP
rs1245075321 391 dbSNP
rs958806445 392 dbSNP
rs780090320 393 dbSNP
rs1347982529 398 dbSNP
rs767942260 402 dbSNP
rs1459149558 403 dbSNP
rs1242479090 404 dbSNP
rs992021258 405 dbSNP
rs1268643281 422 dbSNP
rs992941145 424 dbSNP
rs917341627 425 dbSNP
rs950161283 427 dbSNP
rs1168108623 428 dbSNP
rs1401937834 428 dbSNP
rs1201473660 441 dbSNP
rs1024459170 444 dbSNP
rs1335468929 446 dbSNP
rs557937669 447 dbSNP
rs982959288 450 dbSNP
rs1286385444 454 dbSNP
rs980467321 455 dbSNP
rs908769593 463 dbSNP
rs1214284153 468 dbSNP
rs1188582267 472 dbSNP
rs1239267695 474 dbSNP
rs1468707646 476 dbSNP
rs578074446 477 dbSNP
rs926367062 478 dbSNP
rs553697397 486 dbSNP
rs17357180 488 dbSNP
rs1413279693 496 dbSNP
rs989583981 500 dbSNP
rs913814134 512 dbSNP
rs754907589 531 dbSNP
rs1174649179 538 dbSNP
rs1191185402 543 dbSNP
rs1425392282 557 dbSNP
rs1477927457 558 dbSNP
rs1402028660 561 dbSNP
rs1053107 578 dbSNP
rs899530091 579 dbSNP
rs1040886324 582 dbSNP
rs1336723959 583 dbSNP
rs1360211605 589 dbSNP
rs1333651895 592 dbSNP
rs900976890 596 dbSNP
rs1408635216 614 dbSNP
rs747880796 615 dbSNP
rs1274396594 618 dbSNP
rs771914639 620 dbSNP
rs1221679205 626 dbSNP
rs574064287 627 dbSNP
rs543072164 635 dbSNP
rs1214234204 640 dbSNP
rs1201222466 644 dbSNP
rs1265060498 645 dbSNP
rs1280955259 645 dbSNP
rs1436318093 647 dbSNP
rs768412748 648 dbSNP
rs1280523042 649 dbSNP
rs1362832090 649 dbSNP
rs1419592845 649 dbSNP
rs1491045342 649 dbSNP
rs200339046 649 dbSNP
rs3831951 649 dbSNP
rs57658162 649 dbSNP
rs747816308 649 dbSNP
rs932416959 650 dbSNP
rs1051247950 652 dbSNP
rs1016036309 654 dbSNP
rs1197947074 654 dbSNP
rs897400989 657 dbSNP
rs1352987231 661 dbSNP
rs1491288762 661 dbSNP
rs1491518075 662 dbSNP
rs1375922998 663 dbSNP
rs1288007496 668 dbSNP
rs890884533 668 dbSNP
rs1009326623 672 dbSNP
rs1020764264 673 dbSNP
rs1264856268 674 dbSNP
rs1198999913 675 dbSNP
rs903764839 675 dbSNP
rs772984666 677 dbSNP
rs1231809352 679 dbSNP
rs1183331008 683 dbSNP
rs1439682721 686 dbSNP
rs980682820 692 dbSNP
rs1000768226 702 dbSNP
rs749723930 703 dbSNP
rs1420723256 706 dbSNP
rs1162984195 711 dbSNP
rs559774801 717 dbSNP
rs1033009242 721 dbSNP
rs1308102672 725 dbSNP
rs768845539 731 dbSNP
rs958063929 740 dbSNP
rs958915959 743 dbSNP
rs1376276943 753 dbSNP
rs528758172 775 dbSNP
rs1444571991 788 dbSNP
rs1311412835 792 dbSNP
rs1354269248 795 dbSNP
rs1403006342 795 dbSNP
rs147539738 796 dbSNP
rs1210048562 818 dbSNP
rs1256964642 824 dbSNP
rs1456069307 828 dbSNP
rs1024780468 832 dbSNP
rs971487857 833 dbSNP
rs1331645324 834 dbSNP
rs1240593067 837 dbSNP
rs1440821691 840 dbSNP
rs982929716 842 dbSNP
rs1235088120 844 dbSNP
rs541282292 845 dbSNP
rs374401856 854 dbSNP
rs907711358 857 dbSNP
rs974768663 858 dbSNP
rs1377608903 860 dbSNP
rs1395376682 862 dbSNP
rs532951137 865 dbSNP
rs1310385530 880 dbSNP
rs1204791621 886 dbSNP
rs548000962 887 dbSNP
rs932466823 888 dbSNP
rs1484098911 889 dbSNP
rs1315625880 891 dbSNP
rs932276035 893 dbSNP
rs1050796662 896 dbSNP
rs17163112 898 dbSNP
rs1200400995 904 dbSNP
rs563270105 913 dbSNP
rs941473752 919 dbSNP
rs1425959053 921 dbSNP
rs78094079 923 dbSNP
rs945153828 932 dbSNP
rs1042192253 934 dbSNP
rs371742047 935 dbSNP
rs1423244345 937 dbSNP
rs1476947612 938 dbSNP
rs1201372749 940 dbSNP
rs140159347 947 dbSNP
rs1014213694 954 dbSNP
rs1465557274 956 dbSNP
rs61785869 957 dbSNP
rs111667462 958 dbSNP
rs895073371 962 dbSNP
rs1396409768 963 dbSNP
rs1013307081 970 dbSNP
rs1024335131 974 dbSNP
rs1220074957 979 dbSNP
rs1278372493 981 dbSNP
rs971458428 984 dbSNP
rs1311109434 989 dbSNP
rs1230385697 995 dbSNP
rs1254791810 998 dbSNP
rs1004333735 1005 dbSNP
rs1484514688 1008 dbSNP
rs1033617001 1012 dbSNP
rs1262918263 1025 dbSNP
rs10494394 1026 dbSNP
rs1011043229 1028 dbSNP
rs534988120 1029 dbSNP
rs974277636 1030 dbSNP
rs1173982046 1036 dbSNP
rs921486869 1042 dbSNP
rs922510342 1051 dbSNP
rs954123023 1053 dbSNP
rs1358408309 1073 dbSNP
rs985300618 1092 dbSNP
rs551756930 1093 dbSNP
rs941223927 1096 dbSNP
rs764604300 1098 dbSNP
rs986856033 1099 dbSNP
rs1366414618 1100 dbSNP
rs571825905 1108 dbSNP
rs1298555598 1115 dbSNP
rs1302730935 1126 dbSNP
rs774585267 1128 dbSNP
rs762162724 1129 dbSNP
rs1285858652 1132 dbSNP
rs1351963936 1143 dbSNP
rs1042161298 1147 dbSNP
rs1242938329 1153 dbSNP
rs537279736 1162 dbSNP
rs906104160 1163 dbSNP
rs1489088852 1176 dbSNP
rs555973200 1184 dbSNP
rs1157979380 1188 dbSNP
rs925039870 1191 dbSNP
rs767788666 1193 dbSNP
rs1260055712 1195 dbSNP
rs1378362822 1198 dbSNP
rs1464762986 1199 dbSNP
rs1159540418 1215 dbSNP
rs1421311174 1215 dbSNP
rs557509413 1217 dbSNP
rs936472108 1225 dbSNP
rs1433850506 1226 dbSNP
rs376006959 1232 dbSNP
rs1367708235 1235 dbSNP
rs1054982889 1248 dbSNP
rs1189649315 1255 dbSNP
rs1391583400 1264 dbSNP
rs895034964 1266 dbSNP
rs182324466 1272 dbSNP
rs1442416002 1273 dbSNP
rs187347421 1276 dbSNP
rs1020709189 1277 dbSNP
rs1163380923 1281 dbSNP
rs113975812 1282 dbSNP
rs1459368723 1283 dbSNP
rs569672944 1284 dbSNP
rs1236338773 1288 dbSNP
rs148860823 1288 dbSNP
rs1177640903 1295 dbSNP
rs953753118 1296 dbSNP
rs570669317 1301 dbSNP
rs1004217844 1302 dbSNP
rs1322314975 1304 dbSNP
rs1464664933 1305 dbSNP
rs1367535387 1307 dbSNP
rs1394572012 1308 dbSNP
rs1398791665 1313 dbSNP
rs557803615 1313 dbSNP
rs1444983204 1315 dbSNP
rs116651280 1316 dbSNP
rs962840123 1326 dbSNP
rs1322453818 1327 dbSNP
rs1378910377 1328 dbSNP
rs1226926076 1333 dbSNP
rs1247584378 1335 dbSNP
rs1315135841 1345 dbSNP
rs996056604 1347 dbSNP
rs962829132 1352 dbSNP
rs770627412 1356 dbSNP
rs1028515243 1362 dbSNP
rs754750260 1379 dbSNP
rs954429775 1380 dbSNP
rs1205155973 1383 dbSNP
rs987048489 1385 dbSNP
rs142561602 1387 dbSNP
rs1311752615 1391 dbSNP
rs1250299950 1393 dbSNP
rs563486248 1394 dbSNP
rs1477273448 1405 dbSNP
rs1167998003 1406 dbSNP
rs150991248 1408 dbSNP
rs79516637 1409 dbSNP
rs1330187145 1411 dbSNP
rs558944390 1413 dbSNP
rs528042378 1419 dbSNP
rs190218064 1423 dbSNP
rs764898340 1427 dbSNP
rs1446345976 1431 dbSNP
rs1424998079 1432 dbSNP
rs1315144425 1436 dbSNP
rs936456476 1439 dbSNP
rs1218235914 1442 dbSNP
rs1276478073 1443 dbSNP
rs867924638 1445 dbSNP
rs1320098040 1449 dbSNP
rs754871867 1450 dbSNP
rs991046969 1451 dbSNP
rs79909517 1452 dbSNP
rs949325353 1459 dbSNP
rs778903106 1460 dbSNP
rs1046307375 1461 dbSNP
rs140993675 1462 dbSNP
rs1171460445 1471 dbSNP
rs1425133282 1473 dbSNP
rs115114623 1474 dbSNP
rs368021271 1477 dbSNP
rs569230896 1477 dbSNP
rs1376461617 1478 dbSNP
rs748011894 1479 dbSNP
rs898557553 1481 dbSNP
rs13886 1486 dbSNP
rs1017254992 1487 dbSNP
rs962695371 1495 dbSNP
rs550903949 1496 dbSNP
rs1397811308 1506 dbSNP
rs1352721375 1512 dbSNP
rs972519393 1513 dbSNP
rs1264947336 1517 dbSNP
rs1025458135 1525 dbSNP
rs1197629345 1528 dbSNP
rs971216795 1530 dbSNP
rs1478693155 1534 dbSNP
rs553961307 1535 dbSNP
rs1349691354 1536 dbSNP
rs7414413 1539 dbSNP
rs772695080 1539 dbSNP
rs1028903777 1544 dbSNP
rs890002078 1549 dbSNP
rs927401923 1554 dbSNP
rs1401499314 1563 dbSNP
rs777606655 1565 dbSNP
rs1329430251 1570 dbSNP
rs1443108497 1576 dbSNP
rs567814738 1580 dbSNP
rs1304099685 1581 dbSNP
rs1229624403 1587 dbSNP
rs1270404296 1591 dbSNP
rs990207001 1593 dbSNP
rs1310866055 1595 dbSNP
rs536766960 1599 dbSNP
rs914791220 1600 dbSNP
rs746689765 1601 dbSNP
rs553471091 1611 dbSNP
rs1042005701 1614 dbSNP
rs566956642 1615 dbSNP
rs966948997 1618 dbSNP
rs1193657741 1622 dbSNP
rs1254229900 1625 dbSNP
rs977707687 1628 dbSNP
rs1179299966 1630 dbSNP
rs1032034217 1633 dbSNP
rs1365898518 1637 dbSNP
rs770567194 1648 dbSNP
rs1162893307 1650 dbSNP
rs538687060 1653 dbSNP
rs1463124863 1657 dbSNP
rs1236653933 1660 dbSNP
rs916319018 1666 dbSNP
rs576986152 1667 dbSNP
rs558910693 1668 dbSNP
rs981955439 1671 dbSNP
rs745318486 1672 dbSNP
rs907770209 1689 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 83667.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auaACGUAGAUAGGUUUGGAa 5'
             | ||| |: |||||||| 
Target 5' --cUACAU-UG-CCAAACCUc 3'
 		1 - 17
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_031459 | 3UTR | UACAUUGCCAAACCUCUGACUGCCACAGCUGCAGACUGAGAGGGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_031459 | 3UTR | UUGCCAAACCUCUGACUGCCACAGCUGCAGACUGAGAGGGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_031459 | 3UTR | CUACAUUGCCAAACCUCUGACUGCCACAGCUGCAGACUGAGAGGGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_031459 | 3UTR | CAGGUGACCAUGGCUACAUUGCCAAACCUCUGACUGCCACAGCUGCAGACUGAGAGGGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_031459 | 3UTR | AUGGCUACAUUGCCAAACCUCUGACUGCCACAGCUGCAGACUGAGAGGGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_031459 | 3UTR | UGACCAUGGCUACAUUGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000253063.3 | 3UTR | CUACAUUGCCAAACCUCUGACUGCCACAGCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
81 hsa-miR-4464 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056004 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT061568 BTG2 BTG anti-proliferation factor 2 2 2
MIRT078651 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT087551 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 4
MIRT088139 SEPT2 septin 2 2 4
MIRT095089 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT099065 FOXC1 forkhead box C1 2 4
MIRT150194 MIDN midnolin 2 2
MIRT178173 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT178942 C11ORF57 chromosome 11 open reading frame 57 2 2
MIRT188776 SESN2 sestrin 2 2 2
MIRT267026 EFHD2 EF-hand domain family member D2 2 2
MIRT307213 ACVR2B activin A receptor type 2B 2 2
MIRT324750 ACER2 alkaline ceramidase 2 2 2
MIRT442732 TEAD1 TEA domain transcription factor 1 2 2
MIRT444087 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT445527 KLF9 Kruppel like factor 9 2 2
MIRT449604 INIP INTS3 and NABP interacting protein 2 2
MIRT451129 ZNF99 zinc finger protein 99 2 2
MIRT452271 RPL30 ribosomal protein L30 2 2
MIRT452486 DDX4 DEAD-box helicase 4 2 2
MIRT454868 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 2 6
MIRT455773 TSPAN6 tetraspanin 6 2 4
MIRT463844 WRN Werner syndrome RecQ like helicase 2 2
MIRT465036 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT465176 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT465294 TRIB3 tribbles pseudokinase 3 2 4
MIRT467931 SLC16A7 solute carrier family 16 member 7 2 2
MIRT471906 NUAK2 NUAK family kinase 2 2 2
MIRT472724 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT479785 CCND1 cyclin D1 2 2
MIRT482446 ADM adrenomedullin 2 10
MIRT485365 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT498399 KIF6 kinesin family member 6 2 2
MIRT503202 ACTB actin beta 2 6
MIRT503819 TMEM242 transmembrane protein 242 2 2
MIRT504706 ZNF117 zinc finger protein 117 2 2
MIRT507802 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT509968 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 4
MIRT517306 ELF4 E74 like ETS transcription factor 4 2 6
MIRT523900 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT532018 NOX5 NADPH oxidase 5 2 2
MIRT535334 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT536944 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 4
MIRT539322 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT540189 GSTM4 glutathione S-transferase mu 4 2 2
MIRT545015 ZNF439 zinc finger protein 439 2 2
MIRT545265 TRIM36 tripartite motif containing 36 2 4
MIRT547230 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 4
MIRT548425 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT549910 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550185 TMEM106C transmembrane protein 106C 2 2
MIRT550775 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT552401 ZNF487P zinc finger protein 487 1 1
MIRT554782 RHEBP1 RHEB pseudogene 1 2 4
MIRT557311 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT558635 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT563168 RPS14 ribosomal protein S14 2 2
MIRT564886 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT565778 SEPHS1 selenophosphate synthetase 1 2 2
MIRT566480 PDCD4 programmed cell death 4 2 2
MIRT567206 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568931 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT570698 FBXO41 F-box protein 41 2 2
MIRT573474 MTRNR2L9 MT-RNR2-like 9 2 2
MIRT576170 Hmox1 heme oxygenase 1 2 2
MIRT607555 GLI2 GLI family zinc finger 2 2 2
MIRT608203 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609779 VWC2L von Willebrand factor C domain containing protein 2 like 2 4
MIRT616312 CELF2 CUGBP Elav-like family member 2 2 2
MIRT617190 CDH13 cadherin 13 2 2
MIRT626842 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT636438 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT639101 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT691018 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT700008 RPS21 ribosomal protein S21 2 2
MIRT701144 PANK1 pantothenate kinase 1 2 2
MIRT712691 NUDT7 nudix hydrolase 7 2 2
MIRT715505 MAZ MYC associated zinc finger protein 2 2
MIRT722509 PTPRC protein tyrosine phosphatase, receptor type C 2 2
MIRT724982 TNS1 tensin 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4464 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4464 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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