pre-miRNA Information | |
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pre-miRNA | hsa-mir-3679 |
Genomic Coordinates | chr2: 134127125 - 134127192 |
Description | Homo sapiens miR-3679 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||
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Mature miRNA | hsa-miR-3679-5p | |||||||||||||||
Sequence | 6| UGAGGAUAUGGCAGGGAAGGGGA |28 | |||||||||||||||
Evidence | Experimental | |||||||||||||||
Experiments | Illumina | |||||||||||||||
Editing Events in miRNAs |
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DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TXLNA | ||||||||||||||||||||
Synonyms | IL14, TXLN | ||||||||||||||||||||
Description | taxilin alpha | ||||||||||||||||||||
Transcript | NM_175852 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TXLNA | |||||||||||||||||||||
3'UTR of TXLNA (miRNA target sites are highlighted) |
>TXLNA|NM_175852|3'UTR 1 AGAGCCTGGTGTTGGGTCATGCTGGGAAGGGAGCGGCAGCCCAGCCAGGCCTGGCCCATAAAAGGCTCCCATGCTGAGCA 81 GCCCATTGCTGAAGCCAGGATGTTCTGACCTGGCTGGCATCTGGCACTTGCAATTTTGGATTTTGTGGGTCAGTTTTACG 161 TACATAGGGCATTTTGCAAGGCCTTGCAAATGCATTTATACCTGTAAGTGTACAGTGGGCTTGCATTGGGGATGGGGGTG 241 TGTACAGATGAAGTCAGTGGCTTGTCTGTGAGCTGAAGAGTCTTGAGAGGGGCTGTCATCTGTAGCTGCCATCACAGTGA 321 GTTGGCAGAAGTGACTTGAGCATTTCTCTGTCTGATTTGAGGCTCAGACCCCTCCCTGCCCTTCAGAGCTCAAGACAAGT 401 AATACACCCAGGTCTTGACTGCATTTGTCTTGTGAGCAGGGCTTGCTTGGTCAGCTCAGGCCCTCCTAGCTGCTCTGGAG 481 GCTCCTTTGATTCTCTAGACCTGGAAAAGGTGTCCCTAGGCAGAGCCCTGGCAGGGCGCTCAGAGCTGGGGATTTCCTGC 561 CTGGAACAAGGGACCTGGAGAATGTTTTTGCGTGGGATGATGTGCTGGTCAGGAGCCCCTTGGGCATCGCTTCCCCTGCC 641 CTTTGGTAGTGCCAGGACCAGGCCAATGATGCTTCTCAGTAGCCTTATCATTCACAGGTGCCTCTCTAGCCTGCACAAAT 721 GATTGACAAGAGATCACCCAAAGGATTATTTCTGAAGGTGTTTTTTTCTTTATTTCTTTTTCTTTTTTTTTTTTTTTCTT 801 TTTCTTTTTTTTTTGCACATGACAGTGTTTGTATTGAGGACCTTCCAAGGAAGAGGGATGCTGTAGCAGTGGTGCCTGGG 881 TGCCTGGCCTCCAGTGTCCCACCTCCTTCACCACCCCACTTGGCTCCTTTGCCATCTTGATGCTGAGGTTTCCTGTTTGG 961 TGAGATCAGGTTGTTTGTGGTAAAAGAAAGGAAAGGGCTTCTGATGGCTTTGCCACAAGCTTACCTGTGGGTTTCAGTCC 1041 TGAGAGGCCACCACCAGTTCCCATCAGCACTGTCTCCATGCAGCAGTTGCTGGGTCCCATGTCCAGCTGCCTCTTTGGCT 1121 TCATGGGTTTTTCTGCTTCCTGCCCCCACCCCCACATGTGCAATCCTCAAGATTTGTCCTGATTCTATTTCCTGGCACCT 1201 CCCTGCCTGTCCTTGGGGATTCTACTTCTTCCTGTGTGGGAGCCCATAGCTGTTGTCTAACAGGTAAGAAATGAAATTGA 1281 ACTATTGACTGGGCCCCAGAAATCCATAAAATGGCTGCAGACAGTTGTTTCTGTGTCCTGTTCTACCCCCACTCCAGTAC 1361 ATAACTACTATGTACTGTGTAGAGCCATTCTATATGCTGAATGTTCTGCTGTTGCAAACTTGCCAGGGTATTAGCCAGTG 1441 TTTGTGCCAAGCAGTTTTCTGGGACAACAGAATGACTCAGACCAAGATGGATAGGATGGTTAGGGCTTTGCTTCTTGCTG 1521 TTTTTCTTTGAAGCTAGTTCATTGTCCTGCAGGTCCCTTCATCTTCCATACCTAGCCCACTCTTTTAGCCCTTACCTTAA 1601 ATCTCTCAGATAAGTTGGTTCACAAAGAATGTTAAGTACTGAATCATGTGTGACTGAGACCAGAGATGGCAAATGAATGG 1681 CACACCATTTCTCCTTCTCCTGCCCCAGGGCAGGTACCACTGATCTGCATCAGAGTTGCCTGCTATTCTCTGGTGTATCC 1761 TTCACATCTAGGTGCCCTCAAGCAGCTGTGTGAGTGTTGAGATCTCTGCCATCTCTGGCTGAGATACTGCTGTCCTGTGA 1841 AGTGTTTCCCATGACCTTTTTCTTCCCCTTTGAATCCCTCTGTCTGGAGTAGTCCTTGCCTCTTCCTGCTCCAGTAGGGC 1921 CTTTTCCCTACCCCAGCCCCTGTGCCAGGCTAAGCTGGTACAAGAGCTGCCAACCTCACAGAGTGTTTGCTAGGCGAGAG 2001 AGGTGCAGGGAAGAGGCAGAGGTATGCACCTTCCCCCTTGAAGAGAGGGGAAAGGCCTACAGTGGCCCACATAATTGCCT 2081 GACTCACACTTCAGCTACCTCTTAATGCCTGTGGAGGGACTGGAGCTGCTGGATCCCAGTGTGGTGGTGTAGGAGGCCAC 2161 AGTGAGCAGGTGGCCCCAGCTGGGTTTCCCAGGTCAGGAATGTGGGCCCCAGGCAAGGTGCAGCCTTTGCTCACAGCTCC 2241 ATCCATGTCTAGACCTTCAGGCCAGTCTGCAGATGAGGTTCCCTACCTTTTTCTTCTCTTCATTGACCAAATCAACCAAT 2321 CACTACAGCTGCTCTGCTTCTGCTTTCCAAAGTAGCCCAGGTCCTGGGCCAGATGCAGGGGAGGTGCCTATCCATGAGTG 2401 AAGGCCAGTGTCTTCCTCACCTGGGTGGGTCCCACACTTGTGACCTCAGTTTTAGGACCAAGATCTGTGTTGGTTTCTTA 2481 GATTGCTAGCTTTTCCTCCAGGGGACCACAGCAGGTGAAGCTCAAGAGCGCATGGCTCTGCTAATAGTAAATTGTTTTCA 2561 GGGCCTTGTCCAGCTGAGAGCTTCATGTCCACCAGATTCTGAGAGGTGTCAGCAGCACTTTTTTTTTTTATTTGTTGTTT 2641 GTTTTCCATGAGGTTATCGGACCATGGGCTGAGCTCAGGCACTTTCTGTAGGAGACTGTTATTTCTGTAAAGATGGTTAT 2721 TTAACCCTCCTCCACCCCATCACGGTGGCCCTGAGGGCTGACCCGGAGGCCAGTGGAGCTGCCTGGTGTCCACGGGGGAG 2801 GGCCAAGGCCTGCTGAGCTGATTCTCCAGCTGCTGCCCCAGCCTTTCCGCCTTGCACAGCACAGAGGTGGTCACCCCAGG 2881 GACAGCCAGGCACCTGCTCCTCTTGCCCTTCCTGGGGGAAGGGAGCTGCCTTCTGTCCCTGTAACTGCTTTCCTTATGGC 2961 CCAGCCCGGCCACTCAGACTTGTTTGAAGCTGCACTGGCAGCTTTTTTGTCTCCTTTGGGTATTCACAACAGCCAGGGAC 3041 TTGATTTTGATGTATTTTAAACCACATTAAATAAAGAGTCTGTTGCCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 3121 AAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 200081.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
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Experimental Support 2 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | TZM-bl | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
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PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL
... - Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Whisnant AW; Bogerd HP; Flores O; Ho P; et al. - mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
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CLIP-seq Support 1 for dataset GSM4903833 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_a |
Location of target site | NM_175852 | 3UTR | UUCAUGGGUUUUUCUGCUUCCUGCCCCCACCCCCACAUGUGCAAUCCUCAAGAUUUGUCCUGAUUCUAUUUCCUGGCACCUCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM4903837 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_b |
Location of target site | NM_175852 | 3UTR | CACAUGUGCAAUCCUCAAGAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM4903838 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_c |
Location of target site | NM_175852 | 3UTR | CUGCCUCUUUGGCUUCAUGGGUUUUUCUGCUUCCUGCCCCCACCCCCACAUGUGCAAUCCUCAAGAUUUGUCCUGAUUCUAUUUCCUGGCACCUCCCUGC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM714645 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / completeT1, repB |
Location of target site | ENST00000373610.3 | 3UTR | CCCCCACCCCCACAUGUGCAAUCCUCAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
CLIP-seq Support 5 for dataset GSM1462574 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | TZM-bl / TZM-bl ami BaL |
Location of target site | ENST00000373610.3 | 3UTR | CUUCCUGCCCCCACCCCCACAUGUGCAAUCCUCAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23592263 / GSE59944 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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55 hsa-miR-3679-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT114494 | PNN | pinin, desmosome associated protein | 2 | 2 | ||||||||
MIRT169967 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 | 2 | 6 | ||||||||
MIRT182181 | POU2F1 | POU class 2 homeobox 1 | 2 | 2 | ||||||||
MIRT189380 | TXLNA | taxilin alpha | 2 | 4 | ||||||||
MIRT364735 | TOR1B | torsin family 1 member B | 2 | 2 | ||||||||
MIRT445477 | KDM6A | lysine demethylase 6A | 2 | 2 | ||||||||
MIRT446333 | ATP5C1 | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | 2 | 2 | ||||||||
MIRT446386 | SYNCRIP | synaptotagmin binding cytoplasmic RNA interacting protein | 2 | 2 | ||||||||
MIRT446971 | SLCO4C1 | solute carrier organic anion transporter family member 4C1 | 2 | 2 | ||||||||
MIRT449793 | C1orf109 | chromosome 1 open reading frame 109 | 2 | 2 | ||||||||
MIRT451211 | PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 2 | 2 | ||||||||
MIRT452098 | NUCB2 | nucleobindin 2 | 2 | 2 | ||||||||
MIRT454036 | DDT | D-dopachrome tautomerase | 2 | 2 | ||||||||
MIRT461708 | ZNF426 | zinc finger protein 426 | 2 | 2 | ||||||||
MIRT464957 | TWIST1 | twist family bHLH transcription factor 1 | 2 | 2 | ||||||||
MIRT465775 | TMOD3 | tropomodulin 3 | 2 | 2 | ||||||||
MIRT466925 | STC2 | stanniocalcin 2 | 2 | 2 | ||||||||
MIRT471388 | PDPR | pyruvate dehydrogenase phosphatase regulatory subunit | 2 | 2 | ||||||||
MIRT473585 | MAT2A | methionine adenosyltransferase 2A | 2 | 2 | ||||||||
MIRT476070 | GRIN2A | glutamate ionotropic receptor NMDA type subunit 2A | 2 | 2 | ||||||||
MIRT477324 | EPHA2 | EPH receptor A2 | 2 | 2 | ||||||||
MIRT478244 | DDX3X | DEAD-box helicase 3, X-linked | 2 | 4 | ||||||||
MIRT480449 | C16orf72 | chromosome 16 open reading frame 72 | 2 | 6 | ||||||||
MIRT481866 | ANKRD50 | ankyrin repeat domain 50 | 2 | 2 | ||||||||
MIRT492032 | TSG101 | tumor susceptibility 101 | 2 | 4 | ||||||||
MIRT493737 | GRAP2 | GRB2-related adaptor protein 2 | 2 | 2 | ||||||||
MIRT495623 | PPP1R1C | protein phosphatase 1 regulatory inhibitor subunit 1C | 2 | 2 | ||||||||
MIRT497590 | SLC23A1 | solute carrier family 23 member 1 | 2 | 2 | ||||||||
MIRT504702 | ZNF117 | zinc finger protein 117 | 2 | 2 | ||||||||
MIRT507794 | CDKN1B | cyclin dependent kinase inhibitor 1B | 2 | 2 | ||||||||
MIRT510653 | TMED7 | transmembrane p24 trafficking protein 7 | 2 | 4 | ||||||||
MIRT525534 | FSIP2 | fibrous sheath interacting protein 2 | 2 | 2 | ||||||||
MIRT531149 | CYGB | cytoglobin | 2 | 2 | ||||||||
MIRT536003 | MED13 | mediator complex subunit 13 | 2 | 2 | ||||||||
MIRT537056 | GPR180 | G protein-coupled receptor 180 | 2 | 2 | ||||||||
MIRT538297 | CSNK2A1 | casein kinase 2 alpha 1 | 2 | 2 | ||||||||
MIRT544755 | C8orf33 | chromosome 8 open reading frame 33 | 2 | 2 | ||||||||
MIRT544927 | MIS18BP1 | MIS18 binding protein 1 | 2 | 2 | ||||||||
MIRT556973 | HSPA4L | heat shock protein family A (Hsp70) member 4 like | 2 | 2 | ||||||||
MIRT561714 | PPP2R2A | protein phosphatase 2 regulatory subunit Balpha | 2 | 2 | ||||||||
MIRT563632 | ZNF460 | zinc finger protein 460 | 2 | 2 | ||||||||
MIRT564705 | ZNF322P1 | zinc finger protein 322 pseudogene 1 | 2 | 2 | ||||||||
MIRT572190 | CALU | calumenin | 2 | 2 | ||||||||
MIRT573900 | MKI67 | marker of proliferation Ki-67 | 2 | 2 | ||||||||
MIRT576073 | Poteg | POTE ankyrin domain family, member G | 2 | 2 | ||||||||
MIRT576150 | Hmox1 | heme oxygenase 1 | 2 | 2 | ||||||||
MIRT614848 | PLEKHA6 | pleckstrin homology domain containing A6 | 2 | 4 | ||||||||
MIRT647592 | FAM109B | family with sequence similarity 109 member B | 2 | 2 | ||||||||
MIRT657009 | KCNMB4 | potassium calcium-activated channel subfamily M regulatory beta subunit 4 | 2 | 2 | ||||||||
MIRT691268 | GET4 | golgi to ER traffic protein 4 | 2 | 2 | ||||||||
MIRT695778 | DENR | density regulated re-initiation and release factor | 2 | 2 | ||||||||
MIRT698089 | TPM1 | tropomyosin 1 | 2 | 2 | ||||||||
MIRT732571 | IGLL5 | immunoglobulin lambda like polypeptide 5 | 1 | 0 | ||||||||
MIRT733722 | NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 3 | 0 | ||||||||
MIRT734354 | GREM1 | gremlin 1, DAN family BMP antagonist | 1 | 0 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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