miRTarBase - #MIRT190328


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pre-miRNA Information
pre-miRNA hsa-mir-4703   
Genomic Coordinates chr13: 51552589 - 51552667
Description Homo sapiens miR-4703 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4703-3p
Sequence 49| UGUAGUUGUAUUGUAUUGCCAC |70
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1460841833 5 dbSNP
rs775733304 5 dbSNP
rs756076492 10 dbSNP
rs1378936855 11 dbSNP
rs1049480258 12 dbSNP
rs555347919 13 dbSNP
rs1343138432 18 dbSNP
rs1011011214 19 dbSNP
rs1008216326 21 dbSNP
rs1238676458 22 dbSNP
Putative Targets

Gene Information
Gene Symbol HSP90AA1   
Synonyms EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2
Description heat shock protein 90 alpha family class A member 1
Transcript NM_001017963   
Other Transcripts NM_005348   
Expression
Putative miRNA Targets on HSP90AA1
3'UTR of HSP90AA1
(miRNA target sites are highlighted)		 
>HSP90AA1|NM_001017963|3'UTR
   1 TCTCTGGCTGAGGGATGACTTACCTGTTCAGTACTCTACAATTCCTCTGATAATATATTTTCAAGGATGTTTTTCTTTAT
  81 TTTTGTTAATATTAAAAAGTCTGTATGGCATGACAACTACTTTAAGGGGAAGATAAGATTTCTGTCTACTAAGTGATGCT
 161 GTGATACCTTAGGCACTAAAGCAGAGCTAGTAATGCTTTTTGAGTTTCATGTTGGTTTATTTTCACAGATTGGGGTAACG
 241 TGCACTGTAAGACGTATGTAACATGATGTTAACTTTGTGGTCTAAAGTGTTTAGCTGTCAAGCCGGATGCCTAAGTAGAC
 321 CAAATCTTGTTATTGAAGTGTTCTGAGCTGTATCTTGATGTTTAGAAAAGTATTCGTTACATCTTGTAGGATCTACTTTT
 401 TGAACTTTTCATTCCCTGTAGTTGACAATTCTGCATGTACTAGTCCTCTAGAAATAGGTTAAACTGAAGCAACTTGATGG
 481 AAGGATCTCTCCACAGGGCTTGTTTTCCAAAGAAAAGTATTGTTTGGAGGAGCAAAGTTAAAAGCCTACCTAAGCATATC
 561 GTAAAGCTGTTCAAAAATAACTCAGACCCAGTCTTGTGGATGGAAATGTAGTGCTCGAGTCACATTCTGCTTAAAGTTGT
 641 AACAAATACAGATGAGTTAAAAGATATTGTGTGACAGTGTCTTATTTAGGGGGAAAGGGGAGTATCTGGATGACAGTTAG
 721 TGCCAAAATGTAAAACATGAGGCGCTAGCAGGAGATGGTTAAACACTAGCTGCTCCAAGGGTTGACATGGTCTTCCCAGC
 801 ATGTACTCAGCAGGTGTGGGGTGGAGCACACGTAGGCACAGAAAACAGGAATGCAGACAACATGCATCCCCTGCGTCCAT
 881 GAGTTACATGTGTTCTCTTAGTGTCCACGTTGTTTTGATGTTATTCATGGAATACCTTCTGTGTTAAATACAGTCACTTA
 961 ATTCCTTGGCCTTAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cacCGUUAUGUUAUGUUGAUGu 5'
             |:|  :||  |||||||| 
Target 5' tctGTATGGCATGACAACTACt 3'
 100 - 121 155.00 -14.10
2 
miRNA  3' caccGUUAUGUUAUGUUGAUGu 5'
              ||:|||  |||||:| | 
Target 5' tgttCAGTACTCTACAATTCCt 3'
 25 - 46 122.00 -11.00
3 
miRNA  3' cacCGUUAUGUUAUGUUG-AUGu 5'
             | |||:||: ||||| |:| 
Target 5' acaGGAATGCAG-ACAACATGCa 3'
 845 - 866 118.00 -14.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN508680 20 COSMIC
COSN31547687 31 COSMIC
COSN30488128 47 COSMIC
COSN5746133 64 COSMIC
COSN30121940 101 COSMIC
COSN30168907 107 COSMIC
COSN23530744 132 COSMIC
COSN22901869 135 COSMIC
COSN31537635 142 COSMIC
COSN22025006 151 COSMIC
COSN28822922 178 COSMIC
COSN31586258 181 COSMIC
COSN31961039 245 COSMIC
COSN17447622 264 COSMIC
COSN20111696 275 COSMIC
COSN14451687 577 COSMIC
COSN7429126 965 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs546002924 1 dbSNP
rs780659343 2 dbSNP
rs750719586 3 dbSNP
rs532698679 4 dbSNP
rs757476486 10 dbSNP
rs972436676 11 dbSNP
rs1353423079 13 dbSNP
rs202202735 16 dbSNP
rs764120109 18 dbSNP
rs1329326877 19 dbSNP
rs1351743545 22 dbSNP
rs758432856 22 dbSNP
rs143088106 23 dbSNP
rs777775631 23 dbSNP
rs766242959 24 dbSNP
rs377540509 29 dbSNP
rs760463855 30 dbSNP
rs772944294 36 dbSNP
rs1220800393 37 dbSNP
rs767323889 38 dbSNP
rs1279269265 39 dbSNP
rs1416319789 40 dbSNP
rs112417493 41 dbSNP
rs35798224 43 dbSNP
rs748749956 44 dbSNP
rs1451713672 45 dbSNP
rs776145818 46 dbSNP
rs770491788 49 dbSNP
rs1244857785 50 dbSNP
rs1489247388 51 dbSNP
rs1194027193 56 dbSNP
rs1422668859 56 dbSNP
rs1477608573 57 dbSNP
rs776902863 57 dbSNP
rs1223006118 60 dbSNP
rs963863592 62 dbSNP
rs1019449876 63 dbSNP
rs1323001409 67 dbSNP
rs1008106440 68 dbSNP
rs373854012 72 dbSNP
rs1032129043 75 dbSNP
rs1402404388 75 dbSNP
rs979357162 78 dbSNP
rs1227880643 79 dbSNP
rs1356638592 80 dbSNP
rs966655171 83 dbSNP
rs903132894 84 dbSNP
rs1020266388 89 dbSNP
rs765372871 92 dbSNP
rs1191280796 97 dbSNP
rs1239384871 99 dbSNP
rs1473268819 99 dbSNP
rs1366707721 103 dbSNP
rs965739818 105 dbSNP
rs1019738497 111 dbSNP
rs1006970711 114 dbSNP
rs1293920868 118 dbSNP
rs554591656 119 dbSNP
rs893192002 120 dbSNP
rs116145388 122 dbSNP
rs1340631966 123 dbSNP
rs1157696958 124 dbSNP
rs1446849553 133 dbSNP
rs937454923 137 dbSNP
rs907379409 138 dbSNP
rs1281908470 139 dbSNP
rs1355308477 141 dbSNP
rs1240742947 142 dbSNP
rs555748267 146 dbSNP
rs940947200 148 dbSNP
rs908141653 149 dbSNP
rs1443161593 150 dbSNP
rs1431778524 153 dbSNP
rs1267048104 159 dbSNP
rs982454298 159 dbSNP
rs1441676435 161 dbSNP
rs538999062 163 dbSNP
rs1452266256 167 dbSNP
rs897421259 167 dbSNP
rs930984794 168 dbSNP
rs575335984 172 dbSNP
rs1174615081 173 dbSNP
rs186085934 175 dbSNP
rs919661551 182 dbSNP
rs538361947 186 dbSNP
rs1470179024 188 dbSNP
rs963812142 193 dbSNP
rs762176778 195 dbSNP
rs949105975 197 dbSNP
rs564969774 202 dbSNP
rs1307943075 206 dbSNP
rs1262692509 207 dbSNP
rs55980776 210 dbSNP
rs369711643 214 dbSNP
rs1200061307 218 dbSNP
rs1261439921 220 dbSNP
rs1199279351 228 dbSNP
rs1301633887 228 dbSNP
rs1237657508 229 dbSNP
rs1020634331 230 dbSNP
rs149051840 231 dbSNP
rs146487565 233 dbSNP
rs1174759532 236 dbSNP
rs567256737 239 dbSNP
rs1330025431 240 dbSNP
rs1465826045 240 dbSNP
rs979242729 242 dbSNP
rs375492660 243 dbSNP
rs1301947350 246 dbSNP
rs1330470783 249 dbSNP
rs1230737854 252 dbSNP
rs1435146685 253 dbSNP
rs1034401938 254 dbSNP
rs1320196687 255 dbSNP
rs1312334929 256 dbSNP
rs1219535666 260 dbSNP
rs1257495711 263 dbSNP
rs1479720757 266 dbSNP
rs1170318513 267 dbSNP
rs966922324 269 dbSNP
rs1465175695 273 dbSNP
rs200220551 275 dbSNP
rs397773688 277 dbSNP
rs1377859953 278 dbSNP
rs72520876 279 dbSNP
rs1169603641 280 dbSNP
rs1491132162 280 dbSNP
rs3831488 280 dbSNP
rs397717863 280 dbSNP
rs767388978 280 dbSNP
rs913843293 284 dbSNP
rs976391279 287 dbSNP
rs1293637739 290 dbSNP
rs1001614054 292 dbSNP
rs11547511 294 dbSNP
rs907328376 297 dbSNP
rs1045911909 299 dbSNP
rs2298878 304 dbSNP
rs531569646 305 dbSNP
rs569173401 307 dbSNP
rs1306003236 309 dbSNP
rs954116788 311 dbSNP
rs1465763962 312 dbSNP
rs1266116967 313 dbSNP
rs775842618 315 dbSNP
rs1049795723 316 dbSNP
rs1220981865 316 dbSNP
rs1265790545 323 dbSNP
rs1488846223 326 dbSNP
rs1192454265 331 dbSNP
rs1259179287 332 dbSNP
rs930954268 332 dbSNP
rs1164797766 335 dbSNP
rs1367442420 336 dbSNP
rs1422660414 336 dbSNP
rs115690563 337 dbSNP
rs1483014788 343 dbSNP
rs1256870615 348 dbSNP
rs761876180 352 dbSNP
rs1360053308 354 dbSNP
rs897299238 355 dbSNP
rs1339846410 362 dbSNP
rs1296748815 363 dbSNP
rs1039378197 375 dbSNP
rs942451252 376 dbSNP
rs182139510 378 dbSNP
rs1331563005 380 dbSNP
rs144076402 383 dbSNP
rs1402470925 385 dbSNP
rs540861447 388 dbSNP
rs1054722296 389 dbSNP
rs937644602 390 dbSNP
rs1436946262 393 dbSNP
rs776894543 395 dbSNP
rs1156601083 396 dbSNP
rs1058078 401 dbSNP
rs945257076 405 dbSNP
rs879155627 408 dbSNP
rs1450568020 410 dbSNP
rs1405413219 411 dbSNP
rs1450478753 415 dbSNP
rs1375297812 416 dbSNP
rs1311560692 417 dbSNP
rs1378223517 418 dbSNP
rs913716905 422 dbSNP
rs976063707 424 dbSNP
rs957342013 426 dbSNP
rs1262067450 427 dbSNP
rs1459724917 431 dbSNP
rs1423386202 436 dbSNP
rs1257081139 439 dbSNP
rs1034346315 440 dbSNP
rs1175483573 442 dbSNP
rs1426971092 443 dbSNP
rs1001561838 445 dbSNP
rs1273600149 446 dbSNP
rs11547531 447 dbSNP
rs544933619 448 dbSNP
rs1005030045 449 dbSNP
rs1468441475 451 dbSNP
rs886610297 454 dbSNP
rs879027014 458 dbSNP
rs568538336 472 dbSNP
rs548709077 476 dbSNP
rs1401207536 477 dbSNP
rs995489817 478 dbSNP
rs900803204 480 dbSNP
rs1039331239 485 dbSNP
rs1297006094 486 dbSNP
rs1027097628 487 dbSNP
rs1370386298 487 dbSNP
rs1340608264 491 dbSNP
rs1294624119 492 dbSNP
rs942382721 492 dbSNP
rs912289152 495 dbSNP
rs974551065 496 dbSNP
rs1051288917 499 dbSNP
rs1202329277 508 dbSNP
rs945865634 512 dbSNP
rs1488785290 515 dbSNP
rs913046868 520 dbSNP
rs1410934768 521 dbSNP
rs1399250865 530 dbSNP
rs1162015542 531 dbSNP
rs1479576222 532 dbSNP
rs1173144665 537 dbSNP
rs575140426 541 dbSNP
rs1369081693 544 dbSNP
rs957253629 545 dbSNP
rs927225724 550 dbSNP
rs773910133 554 dbSNP
rs1302913721 557 dbSNP
rs191117771 558 dbSNP
rs186290063 559 dbSNP
rs1024355329 560 dbSNP
rs1212258045 561 dbSNP
rs35754658 561 dbSNP
rs1291412008 567 dbSNP
rs190137720 569 dbSNP
rs1266467374 584 dbSNP
rs1489176904 587 dbSNP
rs11547545 588 dbSNP
rs1242872836 592 dbSNP
rs1475209490 593 dbSNP
rs1166171432 595 dbSNP
rs1287615290 604 dbSNP
rs536071141 606 dbSNP
rs546245419 607 dbSNP
rs1364084023 609 dbSNP
rs1421854434 610 dbSNP
rs900734541 611 dbSNP
rs549111987 614 dbSNP
rs1017830031 616 dbSNP
rs1006472514 617 dbSNP
rs944491130 622 dbSNP
rs890799015 624 dbSNP
rs1355801856 627 dbSNP
rs1216982125 631 dbSNP
rs986030355 633 dbSNP
rs749124836 634 dbSNP
rs945781979 638 dbSNP
rs777749650 640 dbSNP
rs1054680467 641 dbSNP
rs1383887422 645 dbSNP
rs1288661133 649 dbSNP
rs149779281 651 dbSNP
rs935835621 653 dbSNP
rs1384779216 656 dbSNP
rs1398560878 662 dbSNP
rs1335834188 663 dbSNP
rs556803066 666 dbSNP
rs769688719 667 dbSNP
rs1183755168 668 dbSNP
rs1260637479 669 dbSNP
rs1378942161 670 dbSNP
rs1240856653 671 dbSNP
rs1278737743 675 dbSNP
rs34287031 676 dbSNP
rs1386664750 678 dbSNP
rs1002401794 679 dbSNP
rs1203044984 681 dbSNP
rs903568400 686 dbSNP
rs1395860299 687 dbSNP
rs1022379107 688 dbSNP
rs1183212938 697 dbSNP
rs1363559122 704 dbSNP
rs569231446 705 dbSNP
rs1468875883 706 dbSNP
rs983512336 709 dbSNP
rs1429470820 710 dbSNP
rs1468979357 716 dbSNP
rs1334102642 720 dbSNP
rs34767631 722 dbSNP
rs368736722 722 dbSNP
rs1328158532 723 dbSNP
rs552328672 729 dbSNP
rs1235098050 733 dbSNP
rs1275228329 735 dbSNP
rs780982911 743 dbSNP
rs115514898 744 dbSNP
rs1261300689 746 dbSNP
rs1232153544 754 dbSNP
rs566878846 755 dbSNP
rs1459180578 757 dbSNP
rs1244729499 764 dbSNP
rs1196474596 767 dbSNP
rs1250378727 770 dbSNP
rs888941210 773 dbSNP
rs930546203 778 dbSNP
rs973518262 781 dbSNP
rs1197916169 785 dbSNP
rs1452055796 786 dbSNP
rs964850714 787 dbSNP
rs1017777546 790 dbSNP
rs1462008221 791 dbSNP
rs1166842352 795 dbSNP
rs1206274819 795 dbSNP
rs1009094575 798 dbSNP
rs1327906907 799 dbSNP
rs547136209 801 dbSNP
rs974489235 803 dbSNP
rs1404541790 804 dbSNP
rs1281556881 806 dbSNP
rs1228160069 813 dbSNP
rs186947478 813 dbSNP
rs1029722383 814 dbSNP
rs1009931307 818 dbSNP
rs891513223 820 dbSNP
rs1212219445 821 dbSNP
rs1054231685 824 dbSNP
rs181396530 827 dbSNP
rs940009092 828 dbSNP
rs1197744022 829 dbSNP
rs1059623 831 dbSNP
rs992190538 832 dbSNP
rs905704357 833 dbSNP
rs1289448295 836 dbSNP
rs1191778444 839 dbSNP
rs1370902525 843 dbSNP
rs189791627 846 dbSNP
rs1436221466 853 dbSNP
rs1372359989 859 dbSNP
rs1364905750 860 dbSNP
rs926789577 861 dbSNP
rs150605311 865 dbSNP
rs917198702 869 dbSNP
rs1432964490 870 dbSNP
rs1387937390 872 dbSNP
rs544715118 874 dbSNP
rs372342215 875 dbSNP
rs1324800159 879 dbSNP
rs780168650 879 dbSNP
rs1423344436 883 dbSNP
rs1293077935 887 dbSNP
rs572874004 888 dbSNP
rs1177181687 891 dbSNP
rs558996333 896 dbSNP
rs1288624852 902 dbSNP
rs956379016 906 dbSNP
rs542330350 908 dbSNP
rs1008645480 909 dbSNP
rs1183698911 915 dbSNP
rs1396774555 915 dbSNP
rs888993336 916 dbSNP
rs1442717782 923 dbSNP
rs973465918 923 dbSNP
rs964798636 924 dbSNP
rs1454472143 926 dbSNP
rs1050255038 927 dbSNP
rs1383105807 934 dbSNP
rs754032436 935 dbSNP
rs1315826081 936 dbSNP
rs994639505 942 dbSNP
rs1059629 944 dbSNP
rs987621599 950 dbSNP
rs1238804112 951 dbSNP
rs1258536401 953 dbSNP
rs184420805 957 dbSNP
rs745651687 957 dbSNP
rs1459921956 961 dbSNP
rs139925232 964 dbSNP
rs1010296681 965 dbSNP
rs376414746 969 dbSNP
rs1156708658 970 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001017963 | 3UTR | UUAAUAUUAAAAAGUCUGUAUGGCAUGACAACUACUUUAAGGGGAAGAUAAGAUUUCUGUCUACUAAGUGAUGCUGUGAUACCUUAGGCACUAAAGCAGAGCUAGUAAUGCUUUUUGAGUUUCAUGUUGGUUUAUUUUCACAGAUUGGGGUAACGUGCACUGUAAGACGUAUGUAACAUGAUGUUAACUUUGUGGUCUAAAGUGUUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_005348 | 3UTR | AGUCUGUAUGGCAUGACAACUACUUUAAGGGGAAGAUAAGAUUUCUGUCUACUAAGUGAUGCUGUGAUACCUUAGGCACUAAAGCAGAGCUAGUAAUGCUUUUUGAGUUUCAUGUUGGUUUAUUUUCACAGAUUGGGGUAACGUGCACUGUAAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_005348 | 3UTR | CUGUAUGGCAUGACAACUACUUUAAGGGGAAGAUAAGAUUUCUGUCUACUAAGUGAUGCUGUGAUACCUUAGGCACUAAAGCAGAGCUAGUAAUGCUUUUUGAGUUUCAUGUUGGUUUAUUUUCACAGAUUGGGGUAACGUGCACUGUAAGACGUAUGUAACAUGAUGUUAACUUUGUGGUCUAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001017963 | 3UTR | UUGUUAAUAUUAAAAAGUCUGUAUGGCAUGACAACUACUUUAAGGGGAAGAUAAGAUUUCUGUCUACUAAGUGAUGCUGUGAUACCUUAGGCACUAAAGCAGAGCUAGUAAUGCUUUUUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_005348 | 3UTR | ACAACUACUUUAAGGGGAAGAUAAGAUUUCUGUCUACUAAGUGAUGCUGUGAUACCUUAGGCACUAAAGCAGAGCUAGUAAUGCUUUUUGAGUUUCAUGUUGGUUUAUUUUCACAGAUUGGGGUAACGUGCACUGUAAGACGUAUGUAACAUGAUGUUAACUUUGUGGUCUAAAGUGUUUAGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_005348 | 3UTR | UAUGGCAUGACAACUACUUUAAGGGGAAGAUAAGAUUUCUGUCUACUAAGUGAUGCUGUGAUACCUUAGGCACUAAAGCAGAGCUAGUAAUGCUUUUUGAGUUUCAUGUUGGUUUAUUUUCACAGAUUGGGGUAACGUGCACUGUAAGACGUAUGUAACAUGAUGUUAACUUUGUGGUCUAAAGUGUUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000216281.8 | 3UTR | ACUUACCUGUUCAGUACUCUACAAUUCCUCUGAUAAUAUAUUUUCAAGGAUGUUUUUCUUUAUUUUUGUUAAUAUUAAAAAGUCUGUAUGGCAUGACAACUACUUUAAGGGGAAGAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
42 hsa-miR-4703-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT072026 SCP2 sterol carrier protein 2 2 2
MIRT079071 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT106648 PLEKHF2 pleckstrin homology and FYVE domain containing 2 2 4
MIRT178174 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT190328 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT230081 SH3BGRL SH3 domain binding glutamate rich protein like 2 2
MIRT238900 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT473705 MAPK1 mitogen-activated protein kinase 1 2 6
MIRT481891 ANKRD46 ankyrin repeat domain 46 2 4
MIRT483743 ALDH9A1 aldehyde dehydrogenase 9 family member A1 2 2
MIRT488823 MRRF mitochondrial ribosome recycling factor 2 2
MIRT488990 SLC28A1 solute carrier family 28 member 1 2 2
MIRT504173 FAM127B retrotransposon Gag like 8A 2 2
MIRT524461 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT529787 AP4S1 adaptor related protein complex 4 sigma 1 subunit 2 2
MIRT546449 SLC9A7 solute carrier family 9 member A7 2 2
MIRT547827 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 4
MIRT561462 TCERG1 transcription elongation regulator 1 2 2
MIRT562315 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT563644 ZNF675 zinc finger protein 675 2 2
MIRT563741 ZNF107 zinc finger protein 107 2 4
MIRT568318 BACH1 BTB domain and CNC homolog 1 2 2
MIRT571528 ZNF367 zinc finger protein 367 2 2
MIRT574840 CADM1 cell adhesion molecule 1 2 2
MIRT612262 MNT MAX network transcriptional repressor 2 4
MIRT622234 SLC25A45 solute carrier family 25 member 45 2 2
MIRT625372 IRGQ immunity related GTPase Q 2 2
MIRT628260 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT631738 NKX2-1 NK2 homeobox 1 2 2
MIRT646103 GORAB golgin, RAB6 interacting 2 2
MIRT647768 AMOTL1 angiomotin like 1 2 2
MIRT654309 RBMS3 RNA binding motif single stranded interacting protein 3 2 2
MIRT654988 PLCG2 phospholipase C gamma 2 2 2
MIRT659715 CCDC93 coiled-coil domain containing 93 2 2
MIRT666976 PHAX phosphorylated adaptor for RNA export 2 2
MIRT683247 WFDC6 WAP four-disulfide core domain 6 2 2
MIRT688424 DNAL1 dynein axonemal light chain 1 2 2
MIRT691896 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT701616 MYO1B myosin IB 2 2
MIRT702141 MAP3K1 mitogen-activated protein kinase kinase kinase 1 2 2
MIRT704403 CTPS1 CTP synthase 1 2 2
MIRT719515 RAB10 RAB10, member RAS oncogene family 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4703 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4703-3p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4703-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4703-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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