miRTarBase - #MIRT193891


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pre-miRNA Information
pre-miRNA hsa-mir-4524b   
Genomic Coordinates chr17: 69099542 - 69099656
Description Homo sapiens miR-4524b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4524b-3p
Sequence 66| GAGACAGGUUCAUGCUGCUA |85
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1263495678 1 dbSNP
rs1350790266 9 dbSNP
rs1322445998 14 dbSNP
Putative Targets

Gene Information
Gene Symbol HACD3   
Synonyms B-IND1, BIND1, HSPC121, PTPLAD1
Description 3-hydroxyacyl-CoA dehydratase 3
Transcript NM_016395   
Expression
Putative miRNA Targets on HACD3
3'UTR of HACD3
(miRNA target sites are highlighted)		 
>HACD3|NM_016395|3'UTR
   1 AAAGAAAGATTTAGATGGCTTCTTGCCAGTTTGAGCCTAATCTGATTCTTACAGTTTTACCTTCTTGAACCAATGTAAAA
  81 GTTTTTTTAATGTTAAATGATTAAATTCTCAGTGAGGCTATCTTCCTTTTCCCCAGTAACATTCCTGAATTTACTGTTAT
 161 CTTATTGTAGTACTTGCATGACATGGATTCCTGATATCTGATGAGAGGTTCATTCTTGTGTATTCAGTTAATGACACCAA
 241 AAGGCTCAGCCCACCCCAACCCTATCTCATGTTCAGTCTGTCTAATACATGCCAGAGATTTTTTTTTCAAAAAGTGCTTT
 321 ATCCCTACAATGTACTGACAGTTCTTACAGTTGAGATTTGTTCTTTTCAGCTATTGCTTGTGAAAAAAAGCAAGACTATG
 401 TCACTCTATAGAAGGCTGTTAAAGTGACTCAGGCAGGAATTAATTATTCTGTACCTAAGGGGTTACTTGTTTAATGGGAT
 481 GGCATTGACTTTTTGAAAATCAAGTGGACTGAGTCATTGATAAAACATTTCTAAGAGTGGGGCTAGAGAACATACTTTAC
 561 ATCTGACATCCTTTGGCCTAACAACATCTATTATTATAGTGCTCAGCAGTGTGGGCATTGAAGAGGCGCAGAATGCTTTG
 641 AAAGAAACTAATCAGAATCTTGGAACATCATGATCATGCCATTCTTAAGTAAATCAACTATTTTCAACACTGAAGAAAAA
 721 TGAAACATTATTTAGAAAACAATGAGATTACAAGTTCCAAACTCAGCCAGGAATGTGGCTCACACCTGTAATCCCAGCAC
 801 TTTGGGACACCTAGGTGGGAGCATCGCTTGAAGCCAGGAGTTCAAGACCAGCTTGGGCAACGTAGTGAGACCCCTATCTC
 881 TACAAAAAATAAAAAAATTAGCTGGGTGTGATGGCACACACCTGTTGTCCCAGCTACTCAAGAAGCTGAGATGGGAGGAT
 961 CCTGAGCTCAGGAGGTCAAGGCTGCAGTGAGCCGAGATTGTGCCACTGCACTGCAGCTGGGGTGACAGTGCAAGACCCTG
1041 TCTCAAACCAAACCAAACCACACACACACAAACACACATACACACACACACACACGAGGTCCAAATGGTAGCAGGGATCC
1121 AAAGGGAACACAGTATGTAGGTCAAACTGGCAGTAACAGTGTACAGCCTTTGACAAACTAGAAATATTAGAGTAGGCCAA
1201 ACACACCTCCAAACTGTAAGGCTGTGCACAAACATAAAAAATGGCAGCCTTCCATCTCCTGCACTGGCTGAGTCCATTTA
1281 CTTGTGTACTTGTTCTAGTGAGTGGTGGGACTGTACATTTTTGAATAGACCTCAAAAATACTTCATTCTGCTGCTGTTCA
1361 GTTGGCTTTTTAAACCTGTCTGCAGTAGGACACTGAAAACAGCAAGAACTTCGGGGTGAACACCCGCTGATCCTTTAACA
1441 AGGATTTCTGGCAGGAAACTCACAAAAAGGAGAACTGAAAATTTAGACATACAGTTGGCCATTGTAAAAAACATCAGTTT
1521 CCTCTCATACATTCCAAGTAAACCAAGTAAAATAAGTGTTGGAGTAACACTTGCATAAAAGAATTTAAGGAGTGATAGCT
1601 CTTTCTGTTCTGCCATTCCCAACATTCCTGGGGGAAAGGAGACTCAATGAGTTAATACTATTTCACTGAGCCCAAGATGG
1681 AAACTTGGTTTGACCTAAAACATCTGATTAATATAGGCTAGCTGATTTCTTAAAAATTCGTTGCATTGAAGGATATTTTG
1761 CATGTCTGTAACACCTGTCAATACTTGTTTGTATTGATTTCTGATATTCTTGCAGCTGACTACGTGTAATTGGGCAGATC
1841 AGCTTTGCAGTAGATTATGCTGCATCCTCGTGGCAAAATTCTGTATTCTTAGTGATTGTTACAAACCCCTTTATTGCTGT
1921 CTGAGAAAGTGAAAGATTGTGTATTTCTATTAAAACATTTACAATCAAAATTCTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aucguCGUACUUGGACAGAg 5'
               ||| || ||||||| 
Target 5' acagtGCAAGACCCTGTCTc 3'
 1025 - 1044 159.00 -19.40
2 
miRNA  3' auCGUCGUACUUGGACAGAg 5'
            ||  : | ||||||||| 
Target 5' tgGCTTTTTAAACCTGTCTg 3'
 1363 - 1382 154.00 -13.40
3 
miRNA  3' aucgucGUAC---UUGGACAGAg 5'
                ||||   |::|||||| 
Target 5' ctatctCATGTTCAGTCTGTCTa 3'
 262 - 284 138.00 -12.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN4762836 33 COSMIC
COSN31610255 51 COSMIC
COSN31565832 89 COSMIC
COSN31525885 105 COSMIC
COSN5756031 107 COSMIC
COSN16131306 111 COSMIC
COSN30170706 126 COSMIC
COSN31482994 226 COSMIC
COSN31546129 235 COSMIC
COSN30172429 269 COSMIC
COSN31487919 269 COSMIC
COSN17181624 488 COSMIC
COSN21301637 589 COSMIC
COSN31585782 1413 COSMIC
COSN31543530 1427 COSMIC
COSN26482348 1499 COSMIC
COSN8389865 1783 COSMIC
COSN20793808 1918 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1389230647 2 dbSNP
rs1434778932 4 dbSNP
rs1177660994 5 dbSNP
rs1356965380 9 dbSNP
rs371648681 11 dbSNP
rs1422172122 18 dbSNP
rs758492866 19 dbSNP
rs933573363 21 dbSNP
rs1367084559 24 dbSNP
rs762662115 25 dbSNP
rs986360377 29 dbSNP
rs780185946 30 dbSNP
rs948065766 32 dbSNP
rs746879109 33 dbSNP
rs1311695046 43 dbSNP
rs1401177853 51 dbSNP
rs538376724 51 dbSNP
rs1379988651 53 dbSNP
rs1038380827 67 dbSNP
rs1412466261 68 dbSNP
rs1252682727 71 dbSNP
rs1207425990 72 dbSNP
rs142684857 73 dbSNP
rs910727825 76 dbSNP
rs1264811381 78 dbSNP
rs1222130880 82 dbSNP
rs774068600 107 dbSNP
rs1038159628 114 dbSNP
rs533619543 131 dbSNP
rs930078932 131 dbSNP
rs1046872484 147 dbSNP
rs1350761049 154 dbSNP
rs1289780178 156 dbSNP
rs1402571352 158 dbSNP
rs553817401 160 dbSNP
rs758908468 161 dbSNP
rs1350438685 166 dbSNP
rs898218978 168 dbSNP
rs1458851062 184 dbSNP
rs1352028668 186 dbSNP
rs1157340176 187 dbSNP
rs1472448089 189 dbSNP
rs929684722 191 dbSNP
rs1046726608 195 dbSNP
rs1008135726 198 dbSNP
rs184280722 199 dbSNP
rs1018212351 203 dbSNP
rs1489410578 204 dbSNP
rs1258849450 216 dbSNP
rs1207899118 220 dbSNP
rs1329529572 221 dbSNP
rs899458925 226 dbSNP
rs896131662 235 dbSNP
rs1218806700 236 dbSNP
rs1011264610 237 dbSNP
rs1301330249 260 dbSNP
rs1387897525 262 dbSNP
rs11539009 265 dbSNP
rs1319076292 270 dbSNP
rs1457061599 275 dbSNP
rs1389762393 283 dbSNP
rs1161736469 294 dbSNP
rs967141832 299 dbSNP
rs1023472373 300 dbSNP
rs762999597 315 dbSNP
rs539617154 318 dbSNP
rs1199633447 321 dbSNP
rs905058548 328 dbSNP
rs189233960 329 dbSNP
rs1259587789 332 dbSNP
rs1482710027 337 dbSNP
rs1465230683 340 dbSNP
rs1031167926 345 dbSNP
rs1032452988 348 dbSNP
rs73486711 349 dbSNP
rs1413606390 351 dbSNP
rs988214791 361 dbSNP
rs1476764027 365 dbSNP
rs992337987 366 dbSNP
rs1425471256 369 dbSNP
rs1030357404 381 dbSNP
rs916834875 383 dbSNP
rs541826480 386 dbSNP
rs1306622332 392 dbSNP
rs948036569 392 dbSNP
rs1322948030 395 dbSNP
rs1394551237 397 dbSNP
rs1401794019 399 dbSNP
rs779650403 406 dbSNP
rs1173318876 411 dbSNP
rs11638750 412 dbSNP
rs954657139 416 dbSNP
rs1167944586 431 dbSNP
rs11638757 433 dbSNP
rs1449976663 438 dbSNP
rs555313180 455 dbSNP
rs910801310 458 dbSNP
rs1181553744 461 dbSNP
rs974059824 463 dbSNP
rs942234495 464 dbSNP
rs973965962 476 dbSNP
rs1201755477 479 dbSNP
rs1479412507 480 dbSNP
rs1273268727 482 dbSNP
rs375053584 486 dbSNP
rs1228375385 494 dbSNP
rs919401846 504 dbSNP
rs1300396217 547 dbSNP
rs1243084768 549 dbSNP
rs1340173633 553 dbSNP
rs12333 556 dbSNP
rs1219779092 559 dbSNP
rs1411053426 571 dbSNP
rs1309922655 572 dbSNP
rs1047622637 577 dbSNP
rs1329342912 578 dbSNP
rs542739742 580 dbSNP
rs1391976754 584 dbSNP
rs1275608646 587 dbSNP
rs1347460327 589 dbSNP
rs1472348482 589 dbSNP
rs1368830157 591 dbSNP
rs1189260928 596 dbSNP
rs541200253 597 dbSNP
rs151019981 603 dbSNP
rs1205294930 606 dbSNP
rs139975716 624 dbSNP
rs1236182589 628 dbSNP
rs943871276 629 dbSNP
rs1277399848 630 dbSNP
rs543984080 631 dbSNP
rs1356159004 634 dbSNP
rs1285128470 639 dbSNP
rs763951804 640 dbSNP
rs1205713143 641 dbSNP
rs1348895065 643 dbSNP
rs1253892644 654 dbSNP
rs1410533918 662 dbSNP
rs1372415036 665 dbSNP
rs899763584 667 dbSNP
rs563978485 678 dbSNP
rs1404687345 685 dbSNP
rs529564373 701 dbSNP
rs1042726881 706 dbSNP
rs1197578825 712 dbSNP
rs1410800374 714 dbSNP
rs548225807 729 dbSNP
rs949047665 734 dbSNP
rs1473324128 741 dbSNP
rs1244461811 743 dbSNP
rs568099186 754 dbSNP
rs1451503907 765 dbSNP
rs960868653 772 dbSNP
rs1013728139 773 dbSNP
rs868568079 780 dbSNP
rs1023815961 782 dbSNP
rs1430806519 783 dbSNP
rs527260169 784 dbSNP
rs1267750263 795 dbSNP
rs531790620 796 dbSNP
rs1352472864 797 dbSNP
rs1273132150 800 dbSNP
rs193222718 805 dbSNP
rs1331643975 806 dbSNP
rs1325390674 814 dbSNP
rs776527645 815 dbSNP
rs1455446886 820 dbSNP
rs570517381 821 dbSNP
rs1389231141 822 dbSNP
rs1159519275 823 dbSNP
rs1458468028 823 dbSNP
rs1386257217 826 dbSNP
rs974334031 828 dbSNP
rs919928346 835 dbSNP
rs539267742 839 dbSNP
rs768390143 840 dbSNP
rs982846704 841 dbSNP
rs1463878009 844 dbSNP
rs1297158375 848 dbSNP
rs1247789179 849 dbSNP
rs115740828 860 dbSNP
rs1331446798 861 dbSNP
rs185013656 862 dbSNP
rs1218744205 863 dbSNP
rs1276611996 873 dbSNP
rs1432788431 875 dbSNP
rs892276710 877 dbSNP
rs921123072 878 dbSNP
rs11638868 890 dbSNP
rs1043030048 891 dbSNP
rs11634237 891 dbSNP
rs947284903 891 dbSNP
rs1414550617 898 dbSNP
rs1426663353 902 dbSNP
rs1448186470 903 dbSNP
rs1252954215 904 dbSNP
rs376741852 906 dbSNP
rs1009660016 922 dbSNP
rs1235962014 924 dbSNP
rs1209673350 927 dbSNP
rs1208698322 938 dbSNP
rs1030388392 940 dbSNP
rs998931367 941 dbSNP
rs1056861375 947 dbSNP
rs1203011459 949 dbSNP
rs895570471 955 dbSNP
rs189002472 958 dbSNP
rs954728850 960 dbSNP
rs1469526139 964 dbSNP
rs765307872 971 dbSNP
rs776641607 978 dbSNP
rs1448287315 990 dbSNP
rs1360442217 992 dbSNP
rs181723777 994 dbSNP
rs750723592 995 dbSNP
rs1023753594 999 dbSNP
rs369820018 1000 dbSNP
rs1430670835 1003 dbSNP
rs1412057416 1011 dbSNP
rs1181547538 1019 dbSNP
rs973654560 1021 dbSNP
rs143114278 1024 dbSNP
rs995680188 1025 dbSNP
rs950878909 1028 dbSNP
rs146671781 1030 dbSNP
rs1275266203 1037 dbSNP
rs1163896923 1039 dbSNP
rs1392898056 1042 dbSNP
rs1319770693 1044 dbSNP
rs759666424 1044 dbSNP
rs769763653 1044 dbSNP
rs753678270 1049 dbSNP
rs1228575282 1052 dbSNP
rs1025718090 1059 dbSNP
rs1350498371 1059 dbSNP
rs1463957906 1059 dbSNP
rs912592113 1059 dbSNP
rs965434094 1059 dbSNP
rs983200515 1059 dbSNP
rs1491141905 1060 dbSNP
rs766490907 1060 dbSNP
rs140269334 1061 dbSNP
rs1420305908 1063 dbSNP
rs1320094135 1068 dbSNP
rs1264758503 1072 dbSNP
rs1472342325 1072 dbSNP
rs1487449014 1072 dbSNP
rs949080059 1072 dbSNP
rs1044698272 1080 dbSNP
rs10645266 1080 dbSNP
rs1293392846 1080 dbSNP
rs1336604530 1080 dbSNP
rs1437630579 1080 dbSNP
rs71667074 1080 dbSNP
rs752433817 1080 dbSNP
rs775690535 1080 dbSNP
rs1366230804 1082 dbSNP
rs1435518584 1084 dbSNP
rs1456896546 1086 dbSNP
rs1297511395 1090 dbSNP
rs926281606 1094 dbSNP
rs1161419109 1096 dbSNP
rs1431462114 1096 dbSNP
rs936603958 1099 dbSNP
rs1266610568 1101 dbSNP
rs1244054789 1102 dbSNP
rs1469706021 1109 dbSNP
rs1245937758 1110 dbSNP
rs1207756754 1122 dbSNP
rs1053672308 1125 dbSNP
rs892303843 1132 dbSNP
rs543655632 1133 dbSNP
rs1051890958 1136 dbSNP
rs934318274 1137 dbSNP
rs1301263396 1141 dbSNP
rs1235645794 1144 dbSNP
rs757017919 1145 dbSNP
rs1318920275 1156 dbSNP
rs895519525 1158 dbSNP
rs571498247 1159 dbSNP
rs1206302963 1165 dbSNP
rs185697435 1166 dbSNP
rs1290799062 1171 dbSNP
rs1465097955 1172 dbSNP
rs1464617095 1173 dbSNP
rs1018039446 1175 dbSNP
rs1207254361 1181 dbSNP
rs1377139515 1183 dbSNP
rs1176780980 1184 dbSNP
rs1455506751 1185 dbSNP
rs1388198786 1186 dbSNP
rs1254580980 1189 dbSNP
rs150332580 1197 dbSNP
rs367988961 1201 dbSNP
rs559575814 1201 dbSNP
rs995504446 1208 dbSNP
rs1471623317 1210 dbSNP
rs767158155 1215 dbSNP
rs765229542 1218 dbSNP
rs750365194 1219 dbSNP
rs1389617906 1222 dbSNP
rs529497504 1226 dbSNP
rs781683167 1228 dbSNP
rs772459164 1234 dbSNP
rs1350722589 1236 dbSNP
rs905329025 1236 dbSNP
rs1290401593 1241 dbSNP
rs995649232 1246 dbSNP
rs1399726601 1248 dbSNP
rs1395247547 1259 dbSNP
rs1298090208 1262 dbSNP
rs1026558170 1264 dbSNP
rs1357338386 1270 dbSNP
rs887344991 1280 dbSNP
rs1226004423 1286 dbSNP
rs758214907 1287 dbSNP
rs1020031282 1294 dbSNP
rs11325309 1298 dbSNP
rs1167812938 1299 dbSNP
rs1253887978 1305 dbSNP
rs1483106325 1310 dbSNP
rs1201412485 1312 dbSNP
rs1449919515 1312 dbSNP
rs1185022986 1318 dbSNP
rs1422850499 1330 dbSNP
rs1256376945 1331 dbSNP
rs950924873 1332 dbSNP
rs748406079 1342 dbSNP
rs917695312 1343 dbSNP
rs59479777 1366 dbSNP
rs1273118116 1367 dbSNP
rs968517483 1375 dbSNP
rs1340579054 1384 dbSNP
rs980465935 1407 dbSNP
rs188500812 1413 dbSNP
rs11539010 1414 dbSNP
rs547329223 1419 dbSNP
rs781346960 1422 dbSNP
rs778430157 1426 dbSNP
rs1416700593 1427 dbSNP
rs570457535 1431 dbSNP
rs1307404047 1433 dbSNP
rs1410441740 1434 dbSNP
rs1398413744 1437 dbSNP
rs1420974749 1440 dbSNP
rs745592622 1443 dbSNP
rs181321730 1448 dbSNP
rs771685920 1451 dbSNP
rs992791365 1455 dbSNP
rs1189545949 1458 dbSNP
rs1471364164 1459 dbSNP
rs1250411172 1461 dbSNP
rs1377303196 1464 dbSNP
rs1182157352 1467 dbSNP
rs1465337532 1468 dbSNP
rs1172982725 1473 dbSNP
rs1377189147 1474 dbSNP
rs116191808 1478 dbSNP
rs1051608463 1484 dbSNP
rs1356002075 1487 dbSNP
rs890268728 1490 dbSNP
rs185959382 1493 dbSNP
rs775182481 1505 dbSNP
rs1298676909 1506 dbSNP
rs373492214 1512 dbSNP
rs1287770780 1514 dbSNP
rs1234384933 1515 dbSNP
rs994845191 1515 dbSNP
rs1027005656 1535 dbSNP
rs746550625 1539 dbSNP
rs1386014143 1540 dbSNP
rs377653905 1540 dbSNP
rs1394943123 1542 dbSNP
rs887322632 1547 dbSNP
rs1014431229 1560 dbSNP
rs548913401 1567 dbSNP
rs1455300450 1571 dbSNP
rs768655871 1574 dbSNP
rs1410640216 1575 dbSNP
rs1470845214 1579 dbSNP
rs1024447731 1582 dbSNP
rs375244971 1587 dbSNP
rs534716222 1593 dbSNP
rs1468365132 1597 dbSNP
rs1253175822 1599 dbSNP
rs1253997119 1599 dbSNP
rs776633262 1602 dbSNP
rs1463736538 1603 dbSNP
rs1267692241 1604 dbSNP
rs746462402 1612 dbSNP
rs1224421703 1613 dbSNP
rs1352846202 1630 dbSNP
rs547552225 1631 dbSNP
rs558084200 1639 dbSNP
rs1232429856 1648 dbSNP
rs756117213 1650 dbSNP
rs1371525643 1656 dbSNP
rs578048697 1659 dbSNP
rs1432568520 1667 dbSNP
rs1033428605 1671 dbSNP
rs957984921 1675 dbSNP
rs1434046915 1679 dbSNP
rs1402003512 1685 dbSNP
rs989144484 1697 dbSNP
rs996869409 1702 dbSNP
rs1171390014 1704 dbSNP
rs913539547 1714 dbSNP
rs567686377 1715 dbSNP
rs765136852 1719 dbSNP
rs1396168015 1723 dbSNP
rs1195920662 1724 dbSNP
rs1447984280 1727 dbSNP
rs1396597955 1733 dbSNP
rs987345637 1736 dbSNP
rs145324111 1738 dbSNP
rs763272503 1740 dbSNP
rs557469435 1741 dbSNP
rs1199843678 1742 dbSNP
rs1348544596 1752 dbSNP
rs1305456073 1753 dbSNP
rs754227421 1767 dbSNP
rs1364184840 1769 dbSNP
rs1270466605 1772 dbSNP
rs149202611 1773 dbSNP
rs1432431397 1777 dbSNP
rs1355063907 1785 dbSNP
rs943174248 1786 dbSNP
rs1039567565 1787 dbSNP
rs899228839 1789 dbSNP
rs543236981 1792 dbSNP
rs1047736294 1808 dbSNP
rs886419102 1816 dbSNP
rs536219361 1819 dbSNP
rs1419236115 1822 dbSNP
rs1024478830 1824 dbSNP
rs917181335 1825 dbSNP
rs554761670 1827 dbSNP
rs555722341 1835 dbSNP
rs1001709442 1837 dbSNP
rs920284282 1839 dbSNP
rs1282465946 1849 dbSNP
rs1202916395 1850 dbSNP
rs190868669 1855 dbSNP
rs372979192 1857 dbSNP
rs1216065968 1858 dbSNP
rs573438707 1864 dbSNP
rs1283182533 1866 dbSNP
rs1414874307 1870 dbSNP
rs957823208 1871 dbSNP
rs1309823052 1881 dbSNP
rs540693787 1884 dbSNP
rs1061301 1889 dbSNP
rs1428361420 1893 dbSNP
rs1047507997 1903 dbSNP
rs1171602467 1904 dbSNP
rs989608775 1905 dbSNP
rs143347188 1907 dbSNP
rs183972529 1908 dbSNP
rs1164470661 1909 dbSNP
rs1488855157 1912 dbSNP
rs1041296124 1913 dbSNP
rs901439684 1914 dbSNP
rs1480286356 1917 dbSNP
rs987419241 1919 dbSNP
rs1206375781 1923 dbSNP
rs997132156 1929 dbSNP
rs371087429 1936 dbSNP
rs1272231552 1944 dbSNP
rs1195657169 1949 dbSNP
rs1049740834 1951 dbSNP
rs549491362 1952 dbSNP
rs1246455802 1957 dbSNP
rs777450373 1962 dbSNP
rs563038931 1964 dbSNP
rs1408647523 1966 dbSNP
rs529094277 1967 dbSNP
rs1373283044 1971 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auCGUCGUACUUGGACagag 5'
            ||  : | ||||||    
Target 5' ugGCUUUUUAAACCUG---- 3'
 		2 - 17
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796039
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000261875.5 | 3UTR | UUGGCUUUUUAAACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
175 hsa-miR-4524b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064889 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT075345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT094174 PCGF3 polycomb group ring finger 3 2 6
MIRT100109 ABT1 activator of basal transcription 1 2 8
MIRT102242 HBP1 HMG-box transcription factor 1 2 2
MIRT124918 HCCS holocytochrome c synthase 2 2
MIRT140195 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT193891 HACD3 3-hydroxyacyl-CoA dehydratase 3 2 2
MIRT265634 LDHA lactate dehydrogenase A 2 2
MIRT303878 VAMP8 vesicle associated membrane protein 8 2 2
MIRT409756 CRTAP cartilage associated protein 2 4
MIRT441503 SPG20 spartin 2 6
MIRT446882 ZNF554 zinc finger protein 554 2 2
MIRT447093 COPRS coordinator of PRMT5 and differentiation stimulator 2 2
MIRT449987 AEN apoptosis enhancing nuclease 2 2
MIRT452116 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT452654 ZNF33A zinc finger protein 33A 2 2
MIRT453886 IFRD1 interferon related developmental regulator 1 2 12
MIRT454143 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT454501 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 2
MIRT456633 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT457021 ACADSB acyl-CoA dehydrogenase, short/branched chain 2 2
MIRT457055 NEGR1 neuronal growth regulator 1 2 2
MIRT457335 REG4 regenerating family member 4 2 2
MIRT457421 CASC5 kinetochore scaffold 1 2 2
MIRT457940 LCE1A late cornifie