miRTarBase - #MIRT195908


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pre-miRNA Information
pre-miRNA hsa-mir-4491   
Genomic Coordinates chr11: 111347757 - 111347824
Description Homo sapiens miR-4491 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4491
Sequence 46| AAUGUGGACUGGUGUGACCAAA |67
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1043555759 4 dbSNP
rs1182248607 6 dbSNP
rs527936256 7 dbSNP
rs755554417 14 dbSNP
rs779628583 16 dbSNP
rs1471408223 19 dbSNP
rs909066815 20 dbSNP
Putative Targets

Gene Information
Gene Symbol SRSF11   
Synonyms NET2, SFRS11, dJ677H15.2, p54
Description serine and arginine rich splicing factor 11
Transcript NM_004768   
Expression
Putative miRNA Targets on SRSF11
3'UTR of SRSF11
(miRNA target sites are highlighted)		 
>SRSF11|NM_004768|3'UTR
   1 ATATTGCCTCTGAGGGAGTCCAACTGTATACCTGCATCAGTGTCATTCCTTTGTGTGATTTCTTAATGCTGTATTTGTTC
  81 ATCTCAAACCTAGATGTATACAGCTCTGAGTTATAAATGGTTATAAAGCTCCTGTTACTCATATTAGTTATTTACATCAA
 161 AAAGCTTTTAGAAAATGGTACGAGGTAACCAATTCTTGTCATGGTGAAATCTGATTGAGTAACCAAGCAGTTTTACTATT
 241 CTGGTGCTGCTTCATAACAAAAATGAAAAGCTGCATGCATCTACAGCAGGCATGGATTGTTTATGTCGTATGATATCCTT
 321 TATTAAGTAAGTTCACTTATAGTATTTCTATAATTTGATTCATTGCCGTAATAGAGCCATGTAGGAAATGCACTGATTGC
 401 ATGTTATTGTGGCAAGAATATCCTAAATGTCATTAAAATCCTCCAACATGATGGATCTACTTATGGTCTTGTTTGTTGAC
 481 ATGACAAATTAACATTCTTATAGTTACATCTGGAAATGAGCATTTGAAATAGATAATCCTTTAAGCCTTGTGGCAAAATT
 561 TTTGTGGCTTTTGTTTAACTTTGAAAGGTTATTATGCACTAACCTTTTTTGGTGGCTAATTAGGGTTTAAATACAGAAAC
 641 AAGATTTCAAATAAAACTGTCTTTGGCAGTGAGTAAATAGCATATTTTGAAGTAGAGTTGTATACTTTTTCATAAGATGT
 721 TTGGGAATTTTTTTCCTGAAGTAATAATTTATTCCACATCTACATCAGTGAAAGCTATCTACCTATCCTGAGTCTATCTT
 801 AAAGGAAAAAAAGAAAAAAACCTTATCTCTTGCCCTTATTTTGAATTTTCCACTCTTTCATTAATTTGTTTTAAGCTCCG
 881 TGTTGGAAAAAAGGGGTAGTGCATTTTAAATTGACCTTCATACGCTTTTAAAATAAGACAAATCTACTTGATAATGTACC
 961 TTTATTTGATCTCAAGTTGTATAAAACCAATAAATTTGTGTTACTGCAGTAGTAATCTTATGCACACGGTGATTTCATGT
1041 TATATATGCAAAGTAGGCAACTGTTTTCTTAGTTACAGAAGTTTCAAGCTTCACTTTTGTGCAGTAGAAACAAAAGTAGG
1121 CTACAGTCTGTGCCATGTTGATGTACAGTTTCTGAAATTGTTTTACAAGACTTTGATAATAAAACCCTTAAACTTATGTT
1201 CATGTTCCTGTAAAACCGTATTTGTATTTATTTACGCTACTGAATGTATGACATTTACCTCATTCATTTTACAAATTCTT
1281 TCCCTTTCTGTCCACATATTTCAGTATAGTAAAAAGAGGAAGTCTATCACTGTAGTGATAATTGCCATCAAAATTGTCAA
1361 AAATGATTTAATTTCTATCCAAAATAGTCCTTTTCTTAGCTTAGTATCATTTTATTGCTTATTTTTTGTGTGGGAATGGG
1441 GTTGGATAAAGCAATGAACTTTAGTATAAACAAATCCCACCTATATCTAGCAAATTTATATTTTCGGTGAAATACAGATA
1521 TTTGCCTTTCTGGAGTAGTATAGAAGCTGTCAATATGTATCTACTGTACAGTACTAAATAGTATTCATTTATGAAATGAG
1601 TAGTGTTTGGGTGGCTGGGGTTAAGGGAAAATGAGACTTGGAATTGTAGCTTTTATCCAAGTTTTGAGTATAAATAGGGT
1681 TTTGTTTTGTTTTTTTTAACCTAAAAACTGAAATGCCATATAGAAAAACAGCATTGTTTTTACAGTTTGTAGTAAGTAAC
1761 TTTTTAAAGATTTTATCAAAAAGAATTGTCTATAGTGAGTAAAAGAAGTTCTAATAATGGTCCTAATCACTGCATTTTTA
1841 AAAAACAAAGTTCAACACAAATGACATTTGTTTTAAACTTTAGTAGATAAAAGGTGAACCATGTGACATGGGCATTTTTG
1921 TAAGTCAAAAACAAATTTCACATATGGTAAACCTAATATTCACAGTGTGTTCCCTCACTTGTAATCTCTGAATACAAATA
2001 TACTAGCTTTTCTAAAGGGAATCATTTTTTTAAAAGTAGTGCCACTGACAAGATGCTACAGTGAAGATTATCCATTCTTA
2081 GGATATTTATTTTCAGTGAACATTTTCTGCACAAAGGTAGTGTTGCACTGGGACACAAGCCTTTTAACAGATAACCAGTT
2161 GAAATCAAACACTGCCTCCACACCGAGTTCTGTTGTGTATTTGATAGTAAATTGATTTAAAAATAAAAGTGGTTTTTGTT
2241 AGAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaacCAGUGU--GGUCAGGUGUAa 5'
              || |:|  ::| ||||||| 
Target 5' tgaaGTAATAATTTATTCCACATc 3'
 737 - 760 152.00 -8.70
2 
miRNA  3' aaaccAGUG-UGGUCAGGUGUAa 5'
               || |  :| |||||||| 
Target 5' ttcttTCCCTTTCTGTCCACATa 3'
 1276 - 1298 149.00 -11.80
3 
miRNA  3' aaacCAG--UGUG-GUCAGGUGUAa 5'
              |||  | ||  | |:||||| 
Target 5' gtaaGTCAAAAACAAATTTCACATa 3'
 1920 - 1944 132.00 -10.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30489906 9 COSMIC
COSN31508686 19 COSMIC
COSN31538195 73 COSMIC
COSN28888472 94 COSMIC
COSN31598674 133 COSMIC
COSN8506051 133 COSMIC
COSN31597821 182 COSMIC
COSN31512912 369 COSMIC
COSN31660939 410 COSMIC
COSN31660940 412 COSMIC
COSN25436233 660 COSMIC
COSN19394291 1018 COSMIC
COSN31536784 1058 COSMIC
COSN31596750 1059 COSMIC
COSN28198175 1354 COSMIC
COSN17092033 1737 COSMIC
COSN6526265 1992 COSMIC
COSN8506052 2167 COSMIC
COSN8506053 2229 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1361548201 3 dbSNP
rs1402464242 7 dbSNP
rs1276850009 10 dbSNP
rs556064108 17 dbSNP
rs551026163 19 dbSNP
rs757547423 20 dbSNP
rs781578556 23 dbSNP
rs375051675 24 dbSNP
rs1321120110 27 dbSNP
rs373107898 29 dbSNP
rs1290823921 36 dbSNP
rs780181916 38 dbSNP
rs1218436538 46 dbSNP
rs749583127 48 dbSNP
rs763599821 52 dbSNP
rs1422766206 53 dbSNP
rs947948923 54 dbSNP
rs1186897097 63 dbSNP
rs1247258124 72 dbSNP
rs1244737171 73 dbSNP
rs1045034343 82 dbSNP
rs908851330 86 dbSNP
rs1196759866 93 dbSNP
rs571072766 94 dbSNP
rs1296871197 113 dbSNP
rs1036074107 115 dbSNP
rs539991375 122 dbSNP
rs1264383920 125 dbSNP
rs755075953 131 dbSNP
rs1480888297 132 dbSNP
rs775641690 137 dbSNP
rs1453740782 139 dbSNP
rs1180403889 141 dbSNP
rs1236323485 144 dbSNP
rs1327351517 149 dbSNP
rs1052360019 154 dbSNP
rs1399504163 175 dbSNP
rs571393002 182 dbSNP
rs1183988230 189 dbSNP
rs570537374 190 dbSNP
rs1422879282 191 dbSNP
rs1190394548 193 dbSNP
rs1007751646 198 dbSNP
rs116597080 214 dbSNP
rs567212263 215 dbSNP
rs998812573 235 dbSNP
rs1251943518 240 dbSNP
rs1355166569 245 dbSNP
rs1207291791 250 dbSNP
rs1310952903 252 dbSNP
rs536139755 255 dbSNP
rs1235410258 274 dbSNP
rs1348164021 279 dbSNP
rs960390586 280 dbSNP
rs1443970109 281 dbSNP
rs1329904704 282 dbSNP
rs1372027991 286 dbSNP
rs1298242876 289 dbSNP
rs1376884814 291 dbSNP
rs1357297492 292 dbSNP
rs185377979 296 dbSNP
rs1286326224 303 dbSNP
rs1380836510 306 dbSNP
rs188942561 308 dbSNP
rs763066543 309 dbSNP
rs537558927 311 dbSNP
rs1439284838 312 dbSNP
rs1307530478 313 dbSNP
rs1482571697 317 dbSNP
rs1200052634 322 dbSNP
rs764252025 324 dbSNP
rs1350446626 333 dbSNP
rs980663283 341 dbSNP
rs909132508 342 dbSNP
rs1204022690 351 dbSNP
rs752174371 354 dbSNP
rs1036022774 366 dbSNP
rs772445898 368 dbSNP
rs557794954 369 dbSNP
rs1415300476 371 dbSNP
rs1377087135 382 dbSNP
rs933046699 385 dbSNP
rs1453399368 400 dbSNP
rs1051550104 402 dbSNP
rs889253709 407 dbSNP
rs1007700625 427 dbSNP
rs148360288 429 dbSNP
rs1400119387 435 dbSNP
rs1189316363 441 dbSNP
rs778049911 444 dbSNP
rs904789200 449 dbSNP
rs1216263752 464 dbSNP
rs1260899692 465 dbSNP
rs999095418 465 dbSNP
rs11591061 468 dbSNP
rs1217353276 469 dbSNP
rs181551588 471 dbSNP
rs1032086094 486 dbSNP
rs1292109944 492 dbSNP
rs1233885628 494 dbSNP
rs1357284229 498 dbSNP
rs745535122 501 dbSNP
rs74867073 502 dbSNP
rs769399421 503 dbSNP
rs573632356 508 dbSNP
rs1385972067 527 dbSNP
rs1290809831 540 dbSNP
rs1456551461 543 dbSNP
rs1393892577 547 dbSNP
rs1340804581 553 dbSNP
rs186532210 559 dbSNP
rs1476477602 562 dbSNP
rs1219867044 571 dbSNP
rs201923502 574 dbSNP
rs1192950250 589 dbSNP
rs1429443073 593 dbSNP
rs1264265177 595 dbSNP
rs1206578968 599 dbSNP
rs1487293444 605 dbSNP
rs1272062242 616 dbSNP
rs1213702761 617 dbSNP
rs1023070491 619 dbSNP
rs1256020536 623 dbSNP
rs1226459204 625 dbSNP
rs1326844371 641 dbSNP
rs775503910 641 dbSNP
rs1297422938 650 dbSNP
rs189466634 651 dbSNP
rs1370444562 656 dbSNP
rs1326682820 661 dbSNP
rs1463036446 668 dbSNP
rs1398784187 670 dbSNP
rs1167888214 675 dbSNP
rs530901794 681 dbSNP
rs980609288 692 dbSNP
rs1016139866 693 dbSNP
rs1197195684 696 dbSNP
rs1452190957 704 dbSNP
rs963289147 705 dbSNP
rs1193740271 706 dbSNP
rs762418462 710 dbSNP
rs1247764830 713 dbSNP
rs1317176877 714 dbSNP
rs918903986 720 dbSNP
rs1195206210 739 dbSNP
rs1219721124 742 dbSNP
rs933014452 742 dbSNP
rs987602186 745 dbSNP
rs1230722014 746 dbSNP
rs910301726 747 dbSNP
rs768247854 758 dbSNP
rs1443340509 765 dbSNP
rs1440479043 780 dbSNP
rs1392547921 782 dbSNP
rs943504783 782 dbSNP
rs1399178912 784 dbSNP
rs1171200833 788 dbSNP
rs1434435479 793 dbSNP
rs1394130878 794 dbSNP
rs1242856481 795 dbSNP
rs1455285938 798 dbSNP
rs544382000 811 dbSNP
rs1191547781 814 dbSNP
rs1423035521 821 dbSNP
rs1480830758 822 dbSNP
rs757811575 823 dbSNP
rs1438343505 827 dbSNP
rs1043197080 836 dbSNP
rs1449601749 843 dbSNP
rs1174793610 851 dbSNP
rs1423760139 853 dbSNP
rs774463052 854 dbSNP
rs1485246515 861 dbSNP
rs1280755640 864 dbSNP
rs1236843313 871 dbSNP
rs1351776914 880 dbSNP
rs564616133 881 dbSNP
rs1319398973 883 dbSNP
rs533454572 890 dbSNP
rs1239784129 894 dbSNP
rs547248940 896 dbSNP
rs567046282 901 dbSNP
rs904738318 906 dbSNP
rs1401491760 911 dbSNP
rs1414670425 912 dbSNP
rs761793967 924 dbSNP
rs529579688 925 dbSNP
rs549615928 934 dbSNP
rs934902517 939 dbSNP
rs150483217 940 dbSNP
rs1470166121 947 dbSNP
rs895783018 948 dbSNP
rs1014261492 954 dbSNP
rs1474832761 955 dbSNP
rs1023436750 957 dbSNP
rs1212670973 958 dbSNP
rs905939834 963 dbSNP
rs1356061237 967 dbSNP
rs11558481 969 dbSNP
rs1283765463 975 dbSNP
rs1205825996 976 dbSNP
rs1352981952 991 dbSNP
rs1005679616 997 dbSNP
rs575851892 1001 dbSNP
rs1016088385 1007 dbSNP
rs963235413 1009 dbSNP
rs1295519107 1010 dbSNP
rs1398492785 1012 dbSNP
rs1262786893 1014 dbSNP
rs760704119 1016 dbSNP
rs1317254295 1018 dbSNP
rs1400908567 1022 dbSNP
rs865887402 1028 dbSNP
rs954486347 1029 dbSNP
rs1245426335 1030 dbSNP
rs1460862659 1044 dbSNP
rs987160325 1053 dbSNP
rs1474280182 1054 dbSNP
rs910249987 1054 dbSNP
rs1241271588 1059 dbSNP
rs1194223452 1060 dbSNP
rs1478008132 1061 dbSNP
rs943118771 1062 dbSNP
rs1159463006 1064 dbSNP
rs1213072415 1067 dbSNP
rs1336143732 1068 dbSNP
rs1275557854 1077 dbSNP
rs1213295296 1082 dbSNP
rs978503544 1086 dbSNP
rs926096938 1099 dbSNP
rs1366833441 1101 dbSNP
rs372398603 1104 dbSNP
rs369358992 1111 dbSNP
rs1460422873 1113 dbSNP
rs1156454994 1115 dbSNP
rs1395164975 1124 dbSNP
rs1167064260 1126 dbSNP
rs1418597015 1127 dbSNP
rs1359569301 1129 dbSNP
rs896077414 1136 dbSNP
rs950384482 1137 dbSNP
rs1324961925 1138 dbSNP
rs557468080 1139 dbSNP
rs1044401430 1140 dbSNP
rs767433834 1144 dbSNP
rs1203107726 1149 dbSNP
rs1435701439 1160 dbSNP
rs1274156002 1172 dbSNP
rs1005625438 1173 dbSNP
rs750118525 1175 dbSNP
rs1343884653 1186 dbSNP
rs553994284 1187 dbSNP
rs12740082 1191 dbSNP
rs560980590 1194 dbSNP
rs181040223 1198 dbSNP
rs938465121 1205 dbSNP
rs1294757293 1209 dbSNP
rs1440013753 1211 dbSNP
rs1353782709 1215 dbSNP
rs1055640693 1218 dbSNP
rs915790990 1220 dbSNP
rs931259134 1225 dbSNP
rs1048047206 1236 dbSNP
rs1454864882 1237 dbSNP
rs760519051 1237 dbSNP
rs1367270569 1238 dbSNP
rs1003903962 1239 dbSNP
rs1040741558 1243 dbSNP
rs1175488717 1247 dbSNP
rs1480600272 1248 dbSNP
rs533630898 1254 dbSNP
rs1207103902 1265 dbSNP
rs900939226 1266 dbSNP
rs1026612737 1271 dbSNP
rs1211676349 1278 dbSNP
rs763685373 1279 dbSNP
rs1287846244 1287 dbSNP
rs767978406 1295 dbSNP
rs1348146867 1304 dbSNP
rs185781608 1305 dbSNP
rs1372566767 1306 dbSNP
rs1298723967 1308 dbSNP
rs964361160 1312 dbSNP
rs1373464365 1315 dbSNP
rs573474256 1317 dbSNP
rs1028488666 1322 dbSNP
rs1435579542 1331 dbSNP
rs377076646 1331 dbSNP
rs1157042771 1333 dbSNP
rs774443114 1335 dbSNP
rs1408767872 1339 dbSNP
rs1179511058 1343 dbSNP
rs1458122290 1345 dbSNP
rs1474504699 1350 dbSNP
rs542574952 1361 dbSNP
rs978459487 1366 dbSNP
rs1387922299 1375 dbSNP
rs1485800060 1383 dbSNP
rs1257341312 1395 dbSNP
rs1213176197 1396 dbSNP
rs138303564 1403 dbSNP
rs767792008 1406 dbSNP
rs1230227005 1408 dbSNP
rs1402443651 1414 dbSNP
rs1353415622 1416 dbSNP
rs1444231000 1421 dbSNP
rs1011602438 1422 dbSNP
rs765074557 1422 dbSNP
rs1341245727 1424 dbSNP
rs956371323 1429 dbSNP
rs1287374344 1434 dbSNP
rs988987275 1437 dbSNP
rs1020935623 1442 dbSNP
rs1161451149 1443 dbSNP
rs1460338433 1446 dbSNP
rs967089271 1447 dbSNP
rs576252786 1453 dbSNP
rs982120512 1455 dbSNP
rs1282687076 1457 dbSNP
rs1260062094 1462 dbSNP
rs191425541 1463 dbSNP
rs1485340097 1464 dbSNP
rs1199414844 1465 dbSNP
rs959444279 1466 dbSNP
rs991316735 1467 dbSNP
rs1332618207 1471 dbSNP
rs927248595 1474 dbSNP
rs564457291 1475 dbSNP
rs1456829226 1476 dbSNP
rs1038422868 1477 dbSNP
rs897246539 1480 dbSNP
rs994691436 1484 dbSNP
rs1047552474 1485 dbSNP
rs1322655136 1494 dbSNP
rs890308181 1497 dbSNP
rs1189154305 1501 dbSNP
rs915777990 1506 dbSNP
rs907283430 1507 dbSNP
rs750707579 1510 dbSNP
rs964308954 1514 dbSNP
rs533493663 1516 dbSNP
rs142704936 1538 dbSNP
rs1189977838 1540 dbSNP
rs1466780952 1540 dbSNP
rs1330652108 1543 dbSNP
rs1032675755 1547 dbSNP
rs999828672 1547 dbSNP
rs182847931 1553 dbSNP
rs939649168 1558 dbSNP
rs1226339516 1561 dbSNP
rs988992647 1562 dbSNP
rs1219258367 1563 dbSNP
rs1280212756 1564 dbSNP
rs754071969 1571 dbSNP
rs917413472 1572 dbSNP
rs900929293 1574 dbSNP
rs1370420323 1580 dbSNP
rs1326663052 1583 dbSNP
rs932438619 1584 dbSNP
rs1394896174 1585 dbSNP
rs980324725 1597 dbSNP
rs1462780930 1601 dbSNP
rs529446911 1601 dbSNP
rs12094004 1611 dbSNP
rs893988855 1612 dbSNP
rs1170145395 1616 dbSNP
rs1452169525 1617 dbSNP
rs1011091901 1620 dbSNP
rs1021595447 1639 dbSNP
rs902769547 1642 dbSNP
rs1003504395 1644 dbSNP
rs1038371973 1650 dbSNP
rs918622442 1670 dbSNP
rs930058108 1671 dbSNP
rs1483281859 1676 dbSNP
rs1276500273 1679 dbSNP
rs1232456277 1684 dbSNP
rs1304276401 1689 dbSNP
rs1347347316 1689 dbSNP
rs1051644879 1690 dbSNP
rs1334543597 1690 dbSNP
rs34917605 1690 dbSNP
rs1306966847 1691 dbSNP
rs1193703315 1698 dbSNP
rs185923336 1699 dbSNP
rs1372852830 1700 dbSNP
rs1311437119 1701 dbSNP
rs1432483642 1703 dbSNP
rs944546356 1704 dbSNP
rs1476579670 1717 dbSNP
rs1169655598 1722 dbSNP
rs959434802 1725 dbSNP
rs990928896 1732 dbSNP
rs531905315 1735 dbSNP
rs1181074432 1737 dbSNP
rs1467337282 1739 dbSNP
rs555730155 1741 dbSNP
rs1472876561 1742 dbSNP
rs952627321 1745 dbSNP
rs377309147 1749 dbSNP
rs983978457 1750 dbSNP
rs1032623641 1751 dbSNP
rs1485481064 1751 dbSNP
rs1202366025 1753 dbSNP
rs1348695047 1761 dbSNP
rs1400866660 1761 dbSNP
rs1260205578 1764 dbSNP
rs1240466700 1765 dbSNP
rs1300334052 1765 dbSNP
rs908416543 1771 dbSNP
rs1291836280 1773 dbSNP
rs939981060 1776 dbSNP
rs1338479496 1778 dbSNP
rs1255563163 1780 dbSNP
rs754532515 1782 dbSNP
rs1334444723 1783 dbSNP
rs1009960951 1784 dbSNP
rs1024491606 1785 dbSNP
rs1302565919 1785 dbSNP
rs10661326 1786 dbSNP
rs386367285 1786 dbSNP
rs397814396 1786 dbSNP
rs971549080 1786 dbSNP
rs1414036103 1791 dbSNP
rs976380882 1793 dbSNP
rs1474781409 1794 dbSNP
rs922299695 1796 dbSNP
rs1189950134 1797 dbSNP
rs376821404 1804 dbSNP
rs1261134203 1806 dbSNP
rs1255800453 1808 dbSNP
rs550998703 1822 dbSNP
rs570888314 1834 dbSNP
rs1271776654 1841 dbSNP
rs542644965 1843 dbSNP
rs778912356 1853 dbSNP
rs147344346 1857 dbSNP
rs1324264373 1858 dbSNP
rs554747706 1858 dbSNP
rs1185445086 1863 dbSNP
rs893569461 1866 dbSNP
rs12025554 1867 dbSNP
rs1390162752 1880 dbSNP
rs946837914 1882 dbSNP
rs1042561224 1884 dbSNP
rs929979326 1894 dbSNP
rs986865276 1906 dbSNP
rs116458285 1908 dbSNP
rs778364873 1909 dbSNP
rs747673577 1910 dbSNP
rs1035002587 1911 dbSNP
rs139962644 1920 dbSNP
rs1251190184 1921 dbSNP
rs1452627933 1923 dbSNP
rs1292488455 1925 dbSNP
rs895126049 1929 dbSNP
rs1213131065 1930 dbSNP
rs1337080475 1946 dbSNP
rs1296467800 1953 dbSNP
rs1228654081 1954 dbSNP
rs190630374 1956 dbSNP
rs1358929372 1960 dbSNP
rs137883624 1965 dbSNP
rs1028121494 1977 dbSNP
rs952166359 1981 dbSNP
rs891435898 1982 dbSNP
rs1325303623 1991 dbSNP
rs1407959587 1998 dbSNP
rs1418486095 2001 dbSNP
rs562960369 2002 dbSNP
rs1385611501 2013 dbSNP
rs1005796376 2022 dbSNP
rs1425681527 2024 dbSNP
rs1301237237 2025 dbSNP
rs1193027271 2032 dbSNP
rs1478657971 2045 dbSNP
rs1248927532 2046 dbSNP
rs777262133 2046 dbSNP
rs1470413306 2049 dbSNP
rs1437665516 2050 dbSNP
rs1275782098 2051 dbSNP
rs1242847308 2057 dbSNP
rs1287652502 2059 dbSNP
rs41302760 2061 dbSNP
rs1300640636 2064 dbSNP
rs1218077200 2065 dbSNP
rs961264747 2068 dbSNP
rs906940930 2073 dbSNP
rs1001324721 2074 dbSNP
rs771303101 2078 dbSNP
rs1034498133 2080 dbSNP
rs922539996 2083 dbSNP
rs1489205123 2085 dbSNP
rs538532167 2099 dbSNP
rs953684277 2102 dbSNP
rs1373819200 2104 dbSNP
rs1173131832 2108 dbSNP
rs1252371315 2111 dbSNP
rs558205108 2113 dbSNP
rs962899696 2117 dbSNP
rs985151280 2123 dbSNP
rs1427329118 2128 dbSNP
rs779610920 2139 dbSNP
rs1440061733 2141 dbSNP
rs578045139 2142 dbSNP
rs1470071638 2144 dbSNP
rs1252996784 2149 dbSNP
rs1378628192 2149 dbSNP
rs1483844304 2155 dbSNP
rs748932470 2156 dbSNP
rs1418752454 2159 dbSNP
rs1208944724 2164 dbSNP
rs946524571 2168 dbSNP
rs1312310832 2179 dbSNP
rs879698770 2183 dbSNP
rs951381337 2186 dbSNP
rs1222068238 2191 dbSNP
rs1351660245 2200 dbSNP
rs1288776483 2206 dbSNP
rs1411389564 2206 dbSNP
rs1353300459 2208 dbSNP
rs1302538415 2214 dbSNP
rs1466733878 2218 dbSNP
rs1361037187 2220 dbSNP
rs1156931197 2233 dbSNP
rs1457188597 2233 dbSNP
rs1456516699 2236 dbSNP
rs1325810684 2238 dbSNP
rs182807352 2248 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aaaccAGUGU--GGUCAGGUGUAa 5'
               | |:|  ::| ||||||| 
Target 5' -----UAAUAAUUUAUUCCACAUc 3'
 		1 - 19
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 9295.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000370950.3 | 3UTR | UAAUAAUUUAUUCCACAUCUACAUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000370950.3 | 3UTR | UAAUAAUUUAUUCCACAUCUACAUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000370950.3 | 3UTR | UAAUAAUUUAUUCCACAUCUACAUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-4491 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056779 ARID5B AT-rich interaction domain 5B 2 2
MIRT061577 BTG2 BTG anti-proliferation factor 2 2 2
MIRT063828 SRP9 signal recognition particle 9 2 4
MIRT102306 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT186634 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT191243 STYX serine/threonine/tyrosine interacting protein 2 2
MIRT195908 SRSF11 serine and arginine rich splicing factor 11 2 4
MIRT240343 UBXN2B UBX domain protein 2B 2 2
MIRT271178 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT286219 TMEM97 transmembrane protein 97 2 4
MIRT314182 OCLN occludin 2 4
MIRT323938 AKAP2 A-kinase anchoring protein 2 2 4
MIRT323940 PALM2-AKAP2 PALM2-AKAP2 readthrough 2 4
MIRT340113 TXLNA taxilin alpha 2 2
MIRT450333 LRWD1 leucine rich repeats and WD repeat domain containing 1 2 2
MIRT451283 ZNF101 zinc finger protein 101 2 2
MIRT451879 SOD2 superoxide dismutase 2 2 8
MIRT453577 CRCP CGRP receptor component 2 2
MIRT454366 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT454797 STOML3 stomatin like 3 2 2
MIRT459801 POTED POTE ankyrin domain family member D 2 10
MIRT460911 POLQ DNA polymerase theta 2 2
MIRT468082 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT470281 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 2
MIRT471876 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT476147 GPR137C G protein-coupled receptor 137C 2 8
MIRT478056 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 10
MIRT501054 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 4
MIRT501732 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT502214 HSPB8 heat shock protein family B (small) member 8 2 2
MIRT505243 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 2
MIRT505957 RAN RAN, member RAS oncogene family 2 6
MIRT507996 BCL2L13 BCL2 like 13 2 4
MIRT510433 ZNF207 zinc finger protein 207 2 6
MIRT510827 SBNO1 strawberry notch homolog 1 2 4
MIRT511493 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 4
MIRT512129 CREBL2 cAMP responsive element binding protein like 2 2 8
MIRT514512 SHISA9 shisa family member 9 2 4
MIRT516482 RAB32 RAB32, member RAS oncogene family 2 4
MIRT519514 RBM22 RNA binding motif protein 22 2 4
MIRT523367 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT524217 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT524649 C4orf32 family with sequence similarity 241 member A 2 2
MIRT528297 ZNF76 zinc finger protein 76 2 2
MIRT528577 ITGB3BP integrin subunit beta 3 binding protein 2 2
MIRT530458 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT535774 MYCN MYCN proto-oncogene, bHLH transcription factor 2 2
MIRT544239 CCBL2 kynurenine aminotransferase 3 2 2
MIRT546733 RNF217 ring finger protein 217 2 2
MIRT550360 INCENP inner centromere protein 2 4
MIRT553343 TRPC3 transient receptor potential cation channel subfamily C member 3 2 4
MIRT556629 LAPTM4A lysosomal protein transmembrane 4 alpha 2 2
MIRT558006 FAM122B family with sequence similarity 122B 2 2
MIRT558994 CA8 carbonic anhydrase 8 2 2
MIRT560418 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565717 SESN3 sestrin 3 2 2
MIRT566271 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 2
MIRT568161 CCDC6 coiled-coil domain containing 6 2 2
MIRT569753 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT573959 FIGNL1 fidgetin like 1 2 2
MIRT574530 PEG10 paternally expressed 10 2 2
MIRT609453 CCDC149 coiled-coil domain containing 149 2 2
MIRT614047 THBS2 thrombospondin 2 2 2
MIRT628418 ATMIN ATM interactor 2 2
MIRT689556 XPO6 exportin 6 2 2
MIRT725598 CDH7 cadherin 7 2 2
MIRT735561 TRIM7 tripartite motif containing 7 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated

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