miRTarBase - #MIRT198492


—
pre-miRNA Information
pre-miRNA hsa-mir-451b   
Genomic Coordinates chr17: 28861371 - 28861438
Description Homo sapiens miR-451b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-451b
Sequence 7| UAGCAAGAGAACCAUUACCAUU |28
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 17 + 28861378 16594986, 27587585 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs761024330 13 dbSNP
rs1173019348 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol USP14   
Synonyms TGT
Description ubiquitin specific peptidase 14
Transcript NM_001037334   
Other Transcripts NM_005151   
Expression
Putative miRNA Targets on USP14
3'UTR of USP14
(miRNA target sites are highlighted)		 
>USP14|NM_001037334|3'UTR
   1 TCTTCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCATTTCTATAATCCAGAGCTTTAGAGGA
  81 AGACACATAGGTGGGTTTATGTTTCACCTCATTTGGAACAAAAGAGGACAGAAGCAGACCACTCTGTGCACCAACCTAAA
 161 AAATTACAGAGAAGAGAAAATTATCTTTGGATTGTGCTGCCCTATATAAAGGTGGCAGAAAGACATTTTTAAAAAGCTTA
 241 TTATTTCTTGCATTATTTTAAAAAGTTCAGAGTTGAAATGCCTTTCAACCATTTCCTTCTGTGGTCATTTTTCTTGCTGC
 321 CTTTTTCACCCAAGATTCAGCAGTCAGATGTTTACTGCACACCTATTACCTATTATTTGCTGTTCTTGCATGGTTCAAAC
 401 CACCATTCTGTAGCCACCCATCCTTTGCCTTATCTAACAAACATTTTTCCAGGAAGGTGGAAAAGGAAGTGTTGCTCTCA
 481 TTGTGTGACTCAGTGCTGCTGTCCATCCCATGGAAACATGGGCACAATCAAGTATTTGTCCAGCCTATTGCAGGCTTTTC
 561 CTGACTTTAAAATAAATTGTGATCAATAATAGTACCTTTGATTATACATTTATTATTGTGTCTCTCTCTGATGTACTGTG
 641 GATTGTACATTTAACTTTGGAATGGCTTTGTAATAATCAGTCTTAAGAAAATGTTGACAAGCTCTGGTTGCTTATTTTTA
 721 GAAAATGAGGACATTTAATAATAATAAAAAAAAAGGGATTAATAGCTTTTGACCTCAAGTCTTTTGTCTTCTGAGTGTTG
 801 GAGCTTGGCTGAAGACATGTTTAATACTGTACAATTTCTGAAGATGGTTATTAACACTGTGCTGTTAAGCATCCATTTAA
 881 AAATATTTGTTATCTTCTTTGCCTGCCTGTATTTTAAAAAGAAATACAAAGTTGTAAAAGTAATGGATTTCTTTGGATGC
 961 TGAATGCAGTGATGTTATCAGTCAGATTCTTTCCTTGGCTCAGTTGTGTTTGTATTTCCTTTCTTAATTCCCCAAATCTT
1041 GGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGTTCACTGGAGGTTGAGTTCGA
1121 GACCAGCCTGGCCACATGGTGAAACCCTGTCTCTACTAAAGATATAAAAATTAGCTGGATGTGGTGGTGCACACCTGTGA
1201 TCCCAGCTACTTGGGAGGCTGAGGTGGGAGAATTGCTTGAACCTGGAAGGCAGAAGTTGCAGTGAGCTGAGATCACACCA
1281 CTGCACTCCAGCCTGGGTGACAGAGAGACTCTGTCTCAAAAAAAAAAAGAAAAAATTCCCAAATCTTAATGTCTGTTTCA
1361 GAATTTTAGTGATTTTAAAGTGATAGTAGAAAATACCAAGCATATGAGGTATTTCAATATGATAGGCTTCTTACATTTTA
1441 ATAGTTACTCATCTTTGTTCCAGGACCCTTGACTGATGCTAGGGAAAGGATAAAGCATAGAATACCAGCCAGTTTGGCTC
1521 TGATTTTGAGTTATTTATAATAAAGTTTGGGGATTATCATAACATCTCATATCTTTGTGTATGTTGTTTTAATGCTCGGC
1601 AGAGCACAACACTGATGATAACTATTAAAAATAGAAAATAACAGCCATTTTACTTTCAAATCTGATGTGATGCAATCTGT
1681 GAACACTAGGAGGGGATAAAATAAGCATTGCAGGGAAACTTATTTGTAAATAGCTTCCTCACCTAAACTTTGACTTGGCA
1761 ATCAATACTTTCTACTTTGTGGAGGGGATTAAGAATAGAATGGGCAGGATGAGACCATGAAAATTATAATGATTCATGTA
1841 TATTTGTATGATGCTTGTAACTTTGCAAAGTCTTTTTTATTCATTGTCTCATTTGGTCAGAACAATTTTATTGAGGACAT
1921 GAATTTAACAATTAGAATTTAGATTTTCTGACTGTAGCTACTAAATGTTGTAGCTACTAGACCAGGTGAGCTAGGTTTAG
2001 AGCAAAGTATATAAGCCTTGTATGGACTATATTAGAATTTTAAAAATTGTAATTAATTCCTTATCATCATTATAAAAAGC
2081 TTGATTTTTTTATTTGATCTAAAAAAGCATTATTCCAAAGAATTTTTTCAAGTAGAAATGGGAGTTAGTTATACCAGTGT
2161 TGTTTTTAACTAATAAGGCTATTTTAGAATTCAGCCTTGCCTGTAAGGTCTTTGAGAAGGGAGAGGAGTAGGCCAAAAAA
2241 AAAAAAGTCTTGATTCCTGAATGTGCCTTATATGCTGTGCCACTCACACCGAGGCCATCATCTCAACATTAGAGTTGTGC
2321 TAGATTACTGCTTGACTGACTAGCTAGGTTAGGCCTAAGAGTGTTTACCGAATAATCTGCACTCACTCAGTAGCCCTTCT
2401 TCAGGATTAAAAACGATGATGACCTCATCTTAGAGCCCTAAAGGGAAATGCTTAT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuACCAUUACCAAGAGAACGAu 5'
            |||| ||  ||:||||||| 
Target 5' tgTGGTCAT--TTTTCTTGCTg 3'
 300 - 319 168.00 -15.70
2 
miRNA  3' uuaCCAUUACCAAGAGAACGau 5'
             | | ||  || ||||||  
Target 5' aaaGCTTATTATT-TCTTGCat 3'
 233 - 253 130.00 -6.90
3 
miRNA  3' uuaccauuACCAAGAGAACGau 5'
                  || | :||||||  
Target 5' ctattattTGCTGTTCTTGCat 3'
 370 - 391 130.00 -6.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30522350 77 COSMIC
COSN30511335 78 COSMIC
COSN30166013 106 COSMIC
COSN4906351 283 COSMIC
COSN30539404 334 COSMIC
COSN31559567 365 COSMIC
COSN26553801 383 COSMIC
COSN20114551 627 COSMIC
COSN7461398 749 COSMIC
COSN20114555 888 COSMIC
COSN30441035 1714 COSMIC
COSN20114561 1844 COSMIC
COSN20114564 2071 COSMIC
COSN31961395 2081 COSMIC
COSN30541477 2158 COSMIC
COSN30165519 2215 COSMIC
COSN20114567 2247 COSMIC
COSN27585721 2247 COSMIC
COSN31569156 2270 COSMIC
COSN29468483 2275 COSMIC
COSN31485550 2301 COSMIC
COSN31584342 2371 COSMIC
COSN6663798 2376 COSMIC
COSN6116042 2571 COSMIC
COSN30432586 2681 COSMIC
COSN27559224 2688 COSMIC
COSN24436391 2833 COSMIC
COSN29913082 2873 COSMIC
COSN6116047 2904 COSMIC
COSN23073835 3211 COSMIC
COSN30478649 3296 COSMIC
COSN31576626 3304 COSMIC
COSN31523352 3330 COSMIC
COSN20046577 3338 COSMIC
COSN29608933 3338 COSMIC
COSN31527036 3339 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1240135915 2 dbSNP
rs745698707 8 dbSNP
rs1305910454 10 dbSNP
rs1200403591 11 dbSNP
rs774128357 13 dbSNP
rs1251657199 14 dbSNP
rs375696289 20 dbSNP
rs377722249 21 dbSNP
rs1244498060 29 dbSNP
rs1043788071 32 dbSNP
rs1444749634 48 dbSNP
rs1323131716 61 dbSNP
rs1313051700 62 dbSNP
rs902251573 73 dbSNP
rs1278838745 92 dbSNP
rs1222678982 100 dbSNP
rs1446105791 106 dbSNP
rs1310847773 108 dbSNP
rs1448096836 109 dbSNP
rs1394475629 112 dbSNP
rs1324285192 127 dbSNP
rs1216315056 136 dbSNP
rs1459810685 139 dbSNP
rs924231836 141 dbSNP
rs999303690 143 dbSNP
rs1158605276 150 dbSNP
rs1399197433 153 dbSNP
rs1382184427 158 dbSNP
rs1179340472 166 dbSNP
rs936800755 168 dbSNP
rs1252365039 169 dbSNP
rs1189226100 172 dbSNP
rs1194946972 181 dbSNP
rs1265849068 184 dbSNP
rs1377572271 184 dbSNP
rs1031824495 185 dbSNP
rs1214576342 188 dbSNP
rs1351073826 193 dbSNP
rs147471746 205 dbSNP
rs376341840 207 dbSNP
rs1287460381 232 dbSNP
rs895963599 238 dbSNP
rs1014442266 242 dbSNP
rs1053887460 252 dbSNP
rs1301929777 263 dbSNP
rs1389063024 266 dbSNP
rs1368686366 269 dbSNP
rs1288670409 273 dbSNP
rs1023180328 281 dbSNP
rs947779326 284 dbSNP
rs1046177242 323 dbSNP
rs1159317696 330 dbSNP
rs906185749 332 dbSNP
rs1173823780 345 dbSNP
rs567980790 350 dbSNP
rs563511282 366 dbSNP
rs1185721273 372 dbSNP
rs888374083 377 dbSNP
rs1264942359 381 dbSNP
rs1216657574 382 dbSNP
rs973425211 383 dbSNP
rs1005359452 398 dbSNP
rs1253762339 402 dbSNP
rs778440611 410 dbSNP
rs963934282 418 dbSNP
rs549853346 423 dbSNP
rs954869762 424 dbSNP
rs983525989 428 dbSNP
rs1400394661 437 dbSNP
rs542942875 439 dbSNP
rs1304678932 444 dbSNP
rs536934837 445 dbSNP
rs772460156 451 dbSNP
rs944513758 458 dbSNP
rs1425542932 464 dbSNP
rs1193868278 476 dbSNP
rs1274975757 478 dbSNP
rs1485147998 480 dbSNP
rs1349488810 481 dbSNP
rs765914478 482 dbSNP
rs1201741366 483 dbSNP
rs1483857985 494 dbSNP
rs1251293574 497 dbSNP
rs1287724810 502 dbSNP
rs1356229310 508 dbSNP
rs1217149296 512 dbSNP
rs1320401526 519 dbSNP
rs974556735 524 dbSNP
rs1232844336 527 dbSNP
rs1338934015 535 dbSNP
rs570773239 536 dbSNP
rs921833052 548 dbSNP
rs1450438803 551 dbSNP
rs561587226 553 dbSNP
rs11558320 556 dbSNP
rs1396723048 560 dbSNP
rs138126708 561 dbSNP
rs1247429148 564 dbSNP
rs1439166029 568 dbSNP
rs1464017048 569 dbSNP
rs1402128369 572 dbSNP
rs1171128367 577 dbSNP
rs1043384060 581 dbSNP
rs11221 582 dbSNP
rs1366411747 583 dbSNP
rs1188994092 599 dbSNP
rs1423929644 601 dbSNP
rs373536207 603 dbSNP
rs1382421499 604 dbSNP
rs1197251932 610 dbSNP
rs1459493014 613 dbSNP
rs1420040517 618 dbSNP
rs1259034062 621 dbSNP
rs16428 621 dbSNP
rs71689559 621 dbSNP
rs202058126 625 dbSNP
rs929595613 626 dbSNP
rs1388459666 627 dbSNP
rs564655854 635 dbSNP
rs1407068635 647 dbSNP
rs113148782 666 dbSNP
rs1444395227 670 dbSNP
rs1056197587 671 dbSNP
rs896244930 675 dbSNP
rs1331773258 685 dbSNP
rs1404600097 692 dbSNP
rs553192331 702 dbSNP
rs1458117019 705 dbSNP
rs376978163 713 dbSNP
rs1014391696 720 dbSNP
rs899656061 721 dbSNP
rs998066782 722 dbSNP
rs1239384371 736 dbSNP
rs1442085564 736 dbSNP
rs1030789859 746 dbSNP
rs1193360030 746 dbSNP
rs1210597291 746 dbSNP
rs1450190624 746 dbSNP
rs532062991 747 dbSNP
rs550190834 749 dbSNP
rs1242478431 752 dbSNP
rs1030944604 755 dbSNP
rs1309938694 772 dbSNP
rs995527254 774 dbSNP
rs1325295766 782 dbSNP
rs1329091134 782 dbSNP
rs1441359891 782 dbSNP
rs990134463 783 dbSNP
rs1359579705 784 dbSNP
rs370293227 786 dbSNP
rs538695067 790 dbSNP
rs1027637660 806 dbSNP
rs1421046447 808 dbSNP
rs1023931264 822 dbSNP
rs969922257 823 dbSNP
rs1248748849 825 dbSNP
rs1477332675 825 dbSNP
rs1200104264 829 dbSNP
rs1446622341 830 dbSNP
rs982310832 833 dbSNP
rs950696148 835 dbSNP
rs1265279974 840 dbSNP
rs1354454260 844 dbSNP
rs776768515 845 dbSNP
rs1279735981 847 dbSNP
rs1004852663 851 dbSNP
rs761858604 857 dbSNP
rs1212080575 858 dbSNP
rs1276394351 860 dbSNP
rs1291231847 864 dbSNP
rs1233783598 869 dbSNP
rs1339424264 884 dbSNP
rs1295915581 886 dbSNP
rs34094861 886 dbSNP
rs35820003 886 dbSNP
rs869141730 886 dbSNP
rs927675856 886 dbSNP
rs982550714 887 dbSNP
rs1196862879 890 dbSNP
rs753170890 892 dbSNP
rs1427934225 893 dbSNP
rs1240226437 895 dbSNP
rs909535085 898 dbSNP
rs1421972566 907 dbSNP
rs1477721838 907 dbSNP
rs536592425 908 dbSNP
rs1488748981 909 dbSNP
rs941039439 910 dbSNP
rs1208194900 913 dbSNP
rs1366570522 914 dbSNP
rs777951371 918 dbSNP
rs1473658603 921 dbSNP
rs1040022009 932 dbSNP
rs1200793851 941 dbSNP
rs1163713704 944 dbSNP
rs548199793 945 dbSNP
rs1399489400 950 dbSNP
rs899748556 954 dbSNP
rs572448787 962 dbSNP
rs966104641 968 dbSNP
rs143592409 979 dbSNP
rs770001146 986 dbSNP
rs773335424 990 dbSNP
rs903050292 992 dbSNP
rs759354206 995 dbSNP
rs979732937 997 dbSNP
rs541584779 1001 dbSNP
rs1398485509 1003 dbSNP
rs1031082365 1007 dbSNP
rs1216414276 1007 dbSNP
rs144167071 1017 dbSNP
rs1395156238 1020 dbSNP
rs1413419416 1020 dbSNP
rs1180173723 1021 dbSNP
rs893807487 1031 dbSNP
rs1010910545 1032 dbSNP
rs1204152346 1039 dbSNP
rs1339010208 1051 dbSNP
rs1457264690 1052 dbSNP
rs1255910727 1058 dbSNP
rs1200365017 1061 dbSNP
rs1024273744 1062 dbSNP
rs374675826 1066 dbSNP
rs1226287570 1074 dbSNP
rs934949270 1075 dbSNP
rs768173975 1080 dbSNP
rs1446614311 1092 dbSNP
rs1294399883 1093 dbSNP
rs1333774749 1099 dbSNP
rs191550953 1119 dbSNP
rs558767419 1120 dbSNP
rs1407304556 1122 dbSNP
rs1414536646 1124 dbSNP
rs1178177048 1126 dbSNP
rs1438989518 1127 dbSNP
rs1236333658 1133 dbSNP
rs1180240751 1136 dbSNP
rs982521037 1139 dbSNP
rs909671019 1140 dbSNP
rs1218851239 1144 dbSNP
rs1323150762 1146 dbSNP
rs1291865767 1147 dbSNP
rs917669926 1149 dbSNP
rs1238872697 1150 dbSNP
rs962650953 1158 dbSNP
rs975111408 1159 dbSNP
rs1448214773 1160 dbSNP
rs947819305 1164 dbSNP
rs753210334 1166 dbSNP
rs1292148610 1182 dbSNP
rs906050391 1190 dbSNP
rs1350742843 1212 dbSNP
rs1158100856 1217 dbSNP
rs201094792 1221 dbSNP
rs374586575 1221 dbSNP
rs1051483768 1224 dbSNP
rs995035546 1227 dbSNP
rs1160334472 1230 dbSNP
rs767397095 1245 dbSNP
rs1200021695 1246 dbSNP
rs886702334 1250 dbSNP
rs1419615846 1269 dbSNP
rs781465097 1269 dbSNP
rs200086346 1274 dbSNP
rs201651146 1274 dbSNP
rs756624943 1275 dbSNP
rs1269218199 1279 dbSNP
rs499634 1281 dbSNP
rs578162410 1283 dbSNP
rs1443883580 1285 dbSNP
rs539131431 1291 dbSNP
rs1487001091 1294 dbSNP
rs1287575292 1301 dbSNP
rs924440819 1302 dbSNP
rs66730713 1309 dbSNP
rs868498040 1309 dbSNP
rs1004803298 1310 dbSNP
rs1172181426 1311 dbSNP
rs1368532009 1313 dbSNP
rs1018942536 1314 dbSNP
rs1052433180 1318 dbSNP
rs1297775881 1318 dbSNP
rs1398407459 1318 dbSNP
rs1460453600 1328 dbSNP
rs1173671807 1330 dbSNP
rs1423805307 1330 dbSNP
rs893900561 1330 dbSNP
rs966093154 1352 dbSNP
rs1429780202 1354 dbSNP
rs1465117177 1354 dbSNP
rs1011296524 1368 dbSNP
rs1045091282 1375 dbSNP
rs1264697347 1381 dbSNP
rs1476635834 1381 dbSNP
rs1300659613 1384 dbSNP
rs557364249 1385 dbSNP
rs1398121910 1386 dbSNP
rs1212897020 1396 dbSNP
rs183753203 1402 dbSNP
rs1277979178 1403 dbSNP
rs796701058 1406 dbSNP
rs1216959233 1409 dbSNP
rs1342688254 1417 dbSNP
rs542960980 1418 dbSNP
rs1217406143 1419 dbSNP
rs1395575831 1422 dbSNP
rs1401374347 1425 dbSNP
rs968254795 1427 dbSNP
rs1308092879 1434 dbSNP
rs1232656055 1439 dbSNP
rs1406474958 1445 dbSNP
rs1169775146 1449 dbSNP
rs951523656 1452 dbSNP
rs1425385742 1458 dbSNP
rs1193232096 1459 dbSNP
rs1254444767 1465 dbSNP
rs748814068 1468 dbSNP
rs1061599 1473 dbSNP
rs923814745 1475 dbSNP
rs1211307664 1476 dbSNP
rs778466588 1480 dbSNP
rs34628720 1482 dbSNP
rs1257817695 1483 dbSNP
rs1016657201 1491 dbSNP
rs962503454 1492 dbSNP
rs573167467 1498 dbSNP
rs991815891 1503 dbSNP
rs4319842 1505 dbSNP
rs1263838439 1510 dbSNP
rs1454502912 1522 dbSNP
rs1383526262 1526 dbSNP
rs1379717974 1529 dbSNP
rs1445086547 1530 dbSNP
rs917617586 1531 dbSNP
rs760681329 1536 dbSNP
rs1168097200 1537 dbSNP
rs947812290 1539 dbSNP
rs1173390103 1540 dbSNP
rs924535724 1542 dbSNP
rs986680041 1542 dbSNP
rs1491579275 1543 dbSNP
rs980906811 1560 dbSNP
rs761796010 1563 dbSNP
rs934461392 1563 dbSNP
rs763991170 1565 dbSNP
rs1459330861 1569 dbSNP
rs370827011 1570 dbSNP
rs1054230324 1571 dbSNP
rs915303580 1590 dbSNP
rs1354518396 1593 dbSNP
rs753328199 1598 dbSNP
rs1045584928 1599 dbSNP
rs1174651367 1606 dbSNP
rs540460626 1610 dbSNP
rs772812026 1613 dbSNP
rs1308384327 1618 dbSNP
rs1300533764 1619 dbSNP
rs1337242390 1619 dbSNP
rs1003991663 1620 dbSNP
rs148685128 1628 dbSNP
rs1388215828 1629 dbSNP
rs569702412 1630 dbSNP
rs1424799708 1633 dbSNP
rs1379178027 1657 dbSNP
rs1157338289 1660 dbSNP
rs1004353406 1666 dbSNP
rs1364679881 1673 dbSNP
rs1198689080 1675 dbSNP
rs1223532286 1678 dbSNP
rs940982575 1678 dbSNP
rs1487982120 1680 dbSNP
rs963226558 1685 dbSNP
rs1237798528 1688 dbSNP
rs532123901 1691 dbSNP
rs1040333303 1696 dbSNP
rs1285590171 1699 dbSNP
rs1199317837 1700 dbSNP
rs1351167584 1702 dbSNP
rs996603682 1703 dbSNP
rs543966015 1704 dbSNP
rs1232311900 1708 dbSNP
rs142080520 1709 dbSNP
rs1029455852 1711 dbSNP
rs1405211385 1718 dbSNP
rs1488143817 1724 dbSNP
rs1295822033 1732 dbSNP
rs1402936350 1735 dbSNP
rs1386369504 1744 dbSNP
rs1172339915 1745 dbSNP
rs1477218251 1746 dbSNP
rs1431947963 1749 dbSNP
rs1200325500 1753 dbSNP
rs1188935643 1754 dbSNP
rs544106958 1758 dbSNP
rs1261108106 1761 dbSNP
rs1218975325 1764 dbSNP
rs1001104328 1773 dbSNP
rs1177558475 1774 dbSNP
rs1284928341 1775 dbSNP
rs1378123257 1775 dbSNP
rs1199823987 1780 dbSNP
rs1030872421 1788 dbSNP
rs1418212590 1791 dbSNP
rs1160867453 1792 dbSNP
rs990050368 1804 dbSNP
rs150716057 1808 dbSNP
rs1432347108 1810 dbSNP
rs1326531396 1811 dbSNP
rs1334041006 1815 dbSNP
rs1457898005 1820 dbSNP
rs1413272566 1826 dbSNP
rs1177676771 1829 dbSNP
rs1408685136 1829 dbSNP
rs948593575 1836 dbSNP
rs1188335155 1837 dbSNP
rs1475753497 1837 dbSNP
rs1237007264 1839 dbSNP
rs201863478 1839 dbSNP
rs35140700 1839 dbSNP
rs374020562 1839 dbSNP
rs759085766 1839 dbSNP
rs1440640622 1841 dbSNP
rs980876793 1845 dbSNP
rs1204131500 1847 dbSNP
rs926702500 1855 dbSNP
rs1369741222 1858 dbSNP
rs1441758146 1861 dbSNP
rs1491230854 1867 dbSNP
rs200087025 1867 dbSNP
rs551890966 1868 dbSNP
rs9303891 1868 dbSNP
rs527560399 1870 dbSNP
rs940235458 1873 dbSNP
rs1446574312 1879 dbSNP
rs1038670957 1885 dbSNP
rs1307514215 1903 dbSNP
rs1172750540 1905 dbSNP
rs969431835 1906 dbSNP
rs898663648 1907 dbSNP
rs1161592955 1911 dbSNP
rs1442690643 1918 dbSNP
rs1244933313 1922 dbSNP
rs1321043980 1927 dbSNP
rs1457125023 1930 dbSNP
rs1219198381 1931 dbSNP
rs980471119 1935 dbSNP
rs1267160141 1937 dbSNP
rs997428288 1941 dbSNP
rs1288524102 1943 dbSNP
rs1226158036 1944 dbSNP
rs758863024 1953 dbSNP
rs1468499600 1954 dbSNP
rs919632546 1961 dbSNP
rs1197494262 1971 dbSNP
rs1235946573 1973 dbSNP
rs1300276710 1976 dbSNP
rs1349580685 1980 dbSNP
rs1441219361 1980 dbSNP
rs1321632732 1981 dbSNP
rs1028040918 1983 dbSNP
rs931118173 1984 dbSNP
rs1007826567 1987 dbSNP
rs1439025874 1993 dbSNP
rs984918538 1994 dbSNP
rs758099371 1996 dbSNP
rs908081364 2003 dbSNP
rs1031280706 2004 dbSNP
rs1423606114 2005 dbSNP
rs1163226391 2008 dbSNP
rs367731566 2008 dbSNP
rs1245819677 2010 dbSNP
rs955736079 2012 dbSNP
rs1490685785 2013 dbSNP
rs990017472 2016 dbSNP
rs1352149030 2026 dbSNP
rs1461997733 2028 dbSNP
rs1315718556 2029 dbSNP
rs1330818912 2030 dbSNP
rs940879313 2034 dbSNP
rs969877379 2036 dbSNP
rs1367140308 2037 dbSNP
rs1040572982 2043 dbSNP
rs1407002077 2047 dbSNP
rs1280362551 2049 dbSNP
rs1343404616 2050 dbSNP
rs1366211815 2050 dbSNP
rs200879840 2050 dbSNP
rs980350504 2052 dbSNP
rs1314727021 2055 dbSNP
rs1335436755 2060 dbSNP
rs1424241092 2060 dbSNP
rs1481220573 2061 dbSNP
rs926697063 2061 dbSNP
rs1217176210 2063 dbSNP
rs144117386 2063 dbSNP
rs59382008 2063 dbSNP
rs939432963 2063 dbSNP
rs1311911747 2066 dbSNP
rs1217461372 2067 dbSNP
rs1225570567 2069 dbSNP
rs200890126 2072 dbSNP
rs1277613376 2073 dbSNP
rs577740848 2085 dbSNP
rs908529399 2085 dbSNP
rs1290516329 2090 dbSNP
rs552445781 2092 dbSNP
rs1358299965 2099 dbSNP
rs1038580726 2109 dbSNP
rs538800250 2117 dbSNP
rs898753391 2123 dbSNP
rs1192270303 2124 dbSNP
rs1426167384 2130 dbSNP
rs1204701429 2135 dbSNP
rs1187559733 2137 dbSNP
rs557986233 2143 dbSNP
rs570650099 2145 dbSNP
rs931934309 2147 dbSNP
rs1324510937 2149 dbSNP
rs1257611302 2156 dbSNP
rs563726838 2158 dbSNP
rs1309262791 2165 dbSNP
rs1007920085 2166 dbSNP
rs1382696560 2167 dbSNP
rs1382026485 2168 dbSNP
rs1420618906 2171 dbSNP
rs1334409540 2175 dbSNP
rs1031418338 2179 dbSNP
rs891458560 2180 dbSNP
rs1050488790 2182 dbSNP
rs116939866 2183 dbSNP
rs1374282591 2184 dbSNP
rs1329731436 2194 dbSNP
rs1358836650 2196 dbSNP
rs747440474 2197 dbSNP
rs1030820371 2204 dbSNP
rs1423713009 2208 dbSNP
rs1241887728 2209 dbSNP
rs1445500976 2209 dbSNP
rs970389911 2210 dbSNP
rs1237959171 2214 dbSNP
rs1001350452 2223 dbSNP
rs144043673 2224 dbSNP
rs1481773940 2227 dbSNP
rs1251961094 2231 dbSNP
rs1399402960 2231 dbSNP
rs1244204017 2232 dbSNP
rs113886010 2235 dbSNP
rs1328005164 2235 dbSNP
rs1358611482 2235 dbSNP
rs138620900 2235 dbSNP
rs1389321107 2235 dbSNP
rs781349773 2235 dbSNP
rs1398235731 2236 dbSNP
rs1035912377 2245 dbSNP
rs1382889714 2246 dbSNP
rs1456927263 2246 dbSNP
rs1165945279 2249 dbSNP
rs1445779976 2250 dbSNP
rs1380063117 2252 dbSNP
rs1319320510 2272 dbSNP
rs1013439422 2273 dbSNP
rs1180189099 2274 dbSNP
rs1421069863 2277 dbSNP
rs959888313 2281 dbSNP
rs146441567 2286 dbSNP
rs969334988 2288 dbSNP
rs980846141 2291 dbSNP
rs1277435628 2292 dbSNP
rs961336146 2294 dbSNP
rs576442077 2296 dbSNP
rs769194685 2296 dbSNP
rs1337334151 2300 dbSNP
rs1307216228 2301 dbSNP
rs1403960508 2304 dbSNP
rs1208440647 2305 dbSNP
rs1363099330 2307 dbSNP
rs569763732 2307 dbSNP
rs1384923373 2308 dbSNP
rs9951575 2309 dbSNP
rs932878364 2312 dbSNP
rs908310665 2315 dbSNP
rs1050040032 2318 dbSNP
rs1479614200 2321 dbSNP
rs912723314 2321 dbSNP
rs9951626 2323 dbSNP
rs1200285301 2333 dbSNP
rs1490487817 2333 dbSNP
rs976221940 2345 dbSNP
rs891554825 2354 dbSNP
rs1476409857 2357 dbSNP
rs1168609231 2359 dbSNP
rs1352494304 2359 dbSNP
rs1011212790 2362 dbSNP
rs763033194 2362 dbSNP
rs769784640 2363 dbSNP
rs1405076870 2370 dbSNP
rs1413041545 2371 dbSNP
rs1316800118 2374 dbSNP
rs905551012 2375 dbSNP
rs1386120546 2380 dbSNP
rs1375768195 2390 dbSNP
rs374225342 2396 dbSNP
rs543841347 2396 dbSNP
rs932284646 2396 dbSNP
rs189092697 2415 dbSNP
rs1004727633 2416 dbSNP
rs558768838 2421 dbSNP
rs1015658406 2425 dbSNP
rs1448723592 2427 dbSNP
rs961472649 2428 dbSNP
rs559947069 2436 dbSNP
rs1430788515 2440 dbSNP
rs1273676057 2445 dbSNP
rs369246343 2453 dbSNP
rs1320942829 2454 dbSNP
rs919910567 2457 dbSNP
rs1223778052 2461 dbSNP
rs1338098088 2462 dbSNP
rs1267909095 2466 dbSNP
rs1433503196 2467 dbSNP
rs878892859 2469 dbSNP
rs577035780 2474 dbSNP
rs1450853123 2475 dbSNP
rs1349112856 2476 dbSNP
rs912815743 2477 dbSNP
rs1216305076 2481 dbSNP
rs944174484 2482 dbSNP
rs1409624930 2486 dbSNP
rs1417444220 2491 dbSNP
rs1169793295 2492 dbSNP
rs544748265 2494 dbSNP
rs562455350 2500 dbSNP
rs3211364 2502 dbSNP
rs912960307 2515 dbSNP
rs1052490851 2520 dbSNP
rs1042840208 2522 dbSNP
rs892562041 2524 dbSNP
rs529778110 2525 dbSNP
rs1194005458 2536 dbSNP
rs1246131495 2539 dbSNP
rs1215869630 2541 dbSNP
rs688023 2544 dbSNP
rs1057039044 2555 dbSNP
rs1244429331 2560 dbSNP
rs1395892404 2564 dbSNP
rs1385369038 2565 dbSNP
rs1337870083 2566 dbSNP
rs895749345 2569 dbSNP
rs1330949028 2570 dbSNP
rs1365065292 2571 dbSNP
rs1410555390 2571 dbSNP
rs1014749579 2574 dbSNP
rs774679565 2574 dbSNP
rs1156565293 2576 dbSNP
rs1182277803 2576 dbSNP
rs1469291392 2577 dbSNP
rs1230772278 2588 dbSNP
rs1387068360 2597 dbSNP
rs1483058765 2603 dbSNP
rs771342391 2606 dbSNP
rs1220891798 2608 dbSNP
rs995991395 2611 dbSNP
rs1328623644 2616 dbSNP
rs1322809982 2621 dbSNP
rs1371660462 2626 dbSNP
rs1347672296 2630 dbSNP
rs1442438737 2632 dbSNP
rs1281446679 2633 dbSNP
rs1443205534 2634 dbSNP
rs1303744890 2637 dbSNP
rs560185316 2637 dbSNP
rs1301434545 2638 dbSNP
rs1367430046 2638 dbSNP
rs1165430580 2643 dbSNP
rs1405528638 2646 dbSNP
rs574424143 2646 dbSNP
rs954142940 2647 dbSNP
rs1472748249 2649 dbSNP
rs1267554262 2654 dbSNP
rs541727318 2654 dbSNP
rs1490977099 2656 dbSNP
rs1266496223 2679 dbSNP
rs1360169471 2680 dbSNP
rs151160978 2680 dbSNP
rs752134871 2680 dbSNP
rs756287358 2680 dbSNP
rs780244627 2683 dbSNP
rs1019794357 2684 dbSNP
rs1307453538 2685 dbSNP
rs1481109082 2686 dbSNP
rs59632306 2687 dbSNP
rs905103798 2687 dbSNP
rs989045913 2687 dbSNP
rs1225591054 2688 dbSNP
rs1353473203 2688 dbSNP
rs397972792 2688 dbSNP
rs372364293 2689 dbSNP
rs913388995 2689 dbSNP
rs1295019780 2690 dbSNP
rs377293190 2690 dbSNP
rs1464633074 2691 dbSNP
rs368569062 2691 dbSNP
rs77153925 2691 dbSNP
rs1225400864 2692 dbSNP
rs1250802428 2692 dbSNP
rs200390939 2692 dbSNP
rs58838924 2692 dbSNP
rs775407910 2692 dbSNP
rs1309356488 2694 dbSNP
rs1449984890 2694 dbSNP
rs144737796 2695 dbSNP
rs936974631 2696 dbSNP
rs1312718465 2697 dbSNP
rs1381693102 2697 dbSNP
rs1253897157 2698 dbSNP
rs1402516995 2699 dbSNP
rs1439258918 2700 dbSNP
rs1002157565 2701 dbSNP
rs1169724647 2701 dbSNP
rs773184132 2701 dbSNP
rs895506925 2701 dbSNP
rs1491566035 2702 dbSNP
rs1365393223 2703 dbSNP
rs940577805 2704 dbSNP
rs563244626 2705 dbSNP
rs776194587 2705 dbSNP
rs1358725114 2706 dbSNP
rs1470383963 2706 dbSNP
rs1162642598 2708 dbSNP
rs1246779553 2708 dbSNP
rs1340879741 2709 dbSNP
rs1305768205 2710 dbSNP
rs1027049803 2712 dbSNP
rs1462591298 2713 dbSNP
rs774923399 2713 dbSNP
rs1424554152 2714 dbSNP
rs764577935 2714 dbSNP
rs1168193690 2715 dbSNP
rs1363585827 2716 dbSNP
rs59833745 2717 dbSNP
rs1289456821 2718 dbSNP
rs1491314622 2718 dbSNP
rs869285723 2718 dbSNP
rs1236431694 2719 dbSNP
rs770194692 2719 dbSNP
rs376368916 2720 dbSNP
rs749433690 2722 dbSNP
rs1288408767 2723 dbSNP
rs146919041 2723 dbSNP
rs372576211 2724 dbSNP
rs755078187 2726 dbSNP
rs1027449584 2727 dbSNP
rs544127690 2727 dbSNP
rs770652577 2727 dbSNP
rs778289784 2727 dbSNP
rs1006820532 2728 dbSNP
rs902931518 2728 dbSNP
rs375058482 2730 dbSNP
rs113588904 2734 dbSNP
rs67330879 2734 dbSNP
rs1330467145 2736 dbSNP
rs1203217422 2740 dbSNP
rs1466106965 2743 dbSNP
rs965377930 2743 dbSNP
rs1222527523 2744 dbSNP
rs952382862 2748 dbSNP
rs1240176232 2768 dbSNP
rs989013369 2774 dbSNP
rs1020531970 2776 dbSNP
rs1316650133 2783 dbSNP
rs1437660415 2783 dbSNP
rs969258263 2789 dbSNP
rs978967242 2792 dbSNP
rs562526832 2793 dbSNP
rs752033751 2793 dbSNP
rs768188788 2793 dbSNP
rs1235235769 2795 dbSNP
rs927012119 2802 dbSNP
rs1173279084 2808 dbSNP
rs1003840545 2811 dbSNP
rs1478304548 2817 dbSNP
rs937087927 2819 dbSNP
rs992609355 2819 dbSNP
rs1457369752 2822 dbSNP
rs145417644 2823 dbSNP
rs201867535 2823 dbSNP
rs376408423 2823 dbSNP
rs538462830 2823 dbSNP
rs546512894 2823 dbSNP
rs576507034 2823 dbSNP
rs756633864 2823 dbSNP
rs781470355 2823 dbSNP
rs1036242581 2824 dbSNP
rs1015256132 2826 dbSNP
rs965137125 2827 dbSNP
rs976212473 2828 dbSNP
rs1252904291 2833 dbSNP
rs923492305 2837 dbSNP
rs548589364 2838 dbSNP
rs953738434 2839 dbSNP
rs1268890880 2840 dbSNP
rs182599052 2841 dbSNP
rs986374814 2842 dbSNP
rs1050289514 2843 dbSNP
rs1314873109 2846 dbSNP
rs1361174217 2848 dbSNP
rs1335133926 2849 dbSNP
rs185522383 2859 dbSNP
rs1006915706 2863 dbSNP
rs1166573146 2869 dbSNP
rs1451313542 2882 dbSNP
rs1390553160 2887 dbSNP
rs1165014502 2888 dbSNP
rs760556861 2895 dbSNP
rs936623240 2896 dbSNP
rs570712269 2901 dbSNP
rs1422374166 2906 dbSNP
rs1463591883 2907 dbSNP
rs1436667256 2909 dbSNP
rs1270344535 2911 dbSNP
rs1169335063 2914 dbSNP
rs1207917416 2915 dbSNP
rs531428163 2916 dbSNP
rs1291479329 2921 dbSNP
rs913985791 2922 dbSNP
rs1244182347 2934 dbSNP
rs75964793 2936 dbSNP
rs190478689 2937 dbSNP
rs1333861247 2939 dbSNP
rs767773936 2939 dbSNP
rs750755027 2944 dbSNP
rs1046647822 2952 dbSNP
rs1334040242 2954 dbSNP
rs764600165 2959 dbSNP
rs905050403 2961 dbSNP
rs1002457983 2963 dbSNP
rs536729329 2971 dbSNP
rs1403348196 2972 dbSNP
rs1417239831 2972 dbSNP
rs1048272807 2975 dbSNP
rs758425480 2975 dbSNP
rs1294432636 2977 dbSNP
rs958897552 2978 dbSNP
rs992577303 2981 dbSNP
rs1268755251 2985 dbSNP
rs1375102897 2996 dbSNP
rs1400770921 3000 dbSNP
rs550448349 3005 dbSNP
rs917007165 3006 dbSNP
rs1291107732 3008 dbSNP
rs753754064 3009 dbSNP
rs961673566 3009 dbSNP
rs1317428827 3012 dbSNP
rs516629 3014 dbSNP
rs1050798842 3015 dbSNP
rs574059049 3015 dbSNP
rs1434292229 3019 dbSNP
rs1003829333 3023 dbSNP
rs1165269531 3024 dbSNP
rs1253332195 3033 dbSNP
rs1015246596 3035 dbSNP
rs910378388 3036 dbSNP
rs965086473 3041 dbSNP
rs1472596707 3043 dbSNP
rs997913535 3053 dbSNP
rs566521556 3054 dbSNP
rs953544624 3056 dbSNP
rs1253735043 3057 dbSNP
rs1247621533 3062 dbSNP
rs1486526800 3063 dbSNP
rs1215579649 3066 dbSNP
rs1463840721 3081 dbSNP
rs1270204628 3082 dbSNP
rs1229246221 3089 dbSNP
rs1322838283 3096 dbSNP
rs1281530418 3097 dbSNP
rs1217377828 3099 dbSNP
rs538975168 3100 dbSNP
rs1369701158 3105 dbSNP
rs1262356379 3112 dbSNP
rs1041067554 3113 dbSNP
rs1429721738 3114 dbSNP
rs1322073519 3115 dbSNP
rs1457500138 3117 dbSNP
rs558700817 3126 dbSNP
rs1427979765 3130 dbSNP
rs1173390125 3142 dbSNP
rs568598587 3143 dbSNP
rs1041701684 3153 dbSNP
rs368302030 3153 dbSNP
rs558830948 3153 dbSNP
rs1491449006 3154 dbSNP
rs1194642945 3155 dbSNP
rs958315459 3162 dbSNP
rs1373308776 3180 dbSNP
rs1461072415 3184 dbSNP
rs1254309860 3187 dbSNP
rs577085107 3192 dbSNP
rs1170445500 3195 dbSNP
rs11309 3203 dbSNP
rs1301819021 3204 dbSNP
rs1227594564 3205 dbSNP
rs949431524 3206 dbSNP
rs538088353 3217 dbSNP
rs982196497 3222 dbSNP
rs1435321908 3223 dbSNP
rs556693230 3224 dbSNP
rs1467094224 3226 dbSNP
rs200187156 3229 dbSNP
rs937818664 3230 dbSNP
rs1428446243 3231 dbSNP
rs376693202 3232 dbSNP
rs1189668526 3234 dbSNP
rs1024031315 3235 dbSNP
rs1254292162 3235 dbSNP
rs142588910 3236 dbSNP
rs3084176 3236 dbSNP
rs754085144 3239 dbSNP
rs879781336 3239 dbSNP
rs1232893379 3242 dbSNP
rs185986237 3243 dbSNP
rs1278438558 3244 dbSNP
rs1349843975 3248 dbSNP
rs1048741572 3249 dbSNP
rs888353500 3252 dbSNP
rs972245156 3253 dbSNP
rs1276483874 3254 dbSNP
rs1228802979 3270 dbSNP
rs939969425 3271 dbSNP
rs1310052520 3277 dbSNP
rs1397432129 3284 dbSNP
rs1211290812 3287 dbSNP
rs1276189182 3298 dbSNP
rs1379246251 3301 dbSNP
rs1187312705 3306 dbSNP
rs749567261 3307 dbSNP
rs759421947 3308 dbSNP
rs1429916108 3309 dbSNP
rs1173074767 3310 dbSNP
rs768664576 3314 dbSNP
rs775312754 3314 dbSNP
rs1372896752 3315 dbSNP
rs760405319 3315 dbSNP
rs1169819199 3318 dbSNP
rs763779700 3318 dbSNP
rs753455081 3322 dbSNP
rs761403758 3322 dbSNP
rs767032854 3322 dbSNP
rs11549435 3328 dbSNP
rs752029619 3328 dbSNP
rs753049806 3328 dbSNP
rs755471713 3328 dbSNP
rs781417012 3328 dbSNP
rs1469786886 3335 dbSNP
rs1335349080 3336 dbSNP
rs1484088864 3337 dbSNP
rs1250576825 3338 dbSNP
rs756388947 3342 dbSNP
rs1450571135 3343 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 9097.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuaccAUUACCAAGAGAACGAu 5'
               | ||  ||:||||||| 
Target 5' -----UCAU--UUUUCUUGCUg 3'
 		1 - 15
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 9097.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuaccAUUACCAAGAGAACGAu 5'
               | ||  ||:||||||| 
Target 5' -----UCAU--UUUUCUUGCUg 3'
 		1 - 15
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000261601.7 | 3UTR | UCAUUUUUCUUGCUGCCUUUUUCACCCAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000261601.7 | 3UTR | UCAUUUUUCUUGCUGCCUUUUUCACCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000261601.7 | 3UTR | UCAUUUUUCUUGCUGCCUUUUUCACCCAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
124 hsa-miR-451b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT060018 VANGL2 VANGL planar cell polarity protein 2 2 4
MIRT069874 SRP54 signal recognition particle 54 2 2
MIRT088316 RAB10 RAB10, member RAS oncogene family 2 4
MIRT100747 VEGFA vascular endothelial growth factor A 5 12
MIRT152236 ZNF460 zinc finger protein 460 2 2
MIRT198492 USP14 ubiquitin specific peptidase 14 2 6
MIRT204750 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT211209 FGF2 fibroblast growth factor 2 2 2
MIRT234352 MSL1 male specific lethal 1 homolog 2 8
MIRT281810 MAP2K1 mitogen-activated protein kinase kinase 1 2 2
MIRT369113 CKMT1A creatine kinase, mitochondrial 1A 2 2
MIRT401349 C5ORF51 chromosome 5 open reading frame 51 2 4
MIRT441509 ERN1 endoplasmic reticulum to nucleus signaling 1 2 2
MIRT441888 RD3 retinal degeneration 3 2 4
MIRT443549 GPR35 G protein-coupled receptor 35 2 2
MIRT444959 ADAM22 ADAM metallopeptidase domain 22 2 2
MIRT445808 NFATC2 nuclear factor of activated T-cells 2 2 2
MIRT446509 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT447457 ST18 ST18, C2H2C-type zinc finger 2 2
MIRT448296 ZDHHC3 zinc finger DHHC-type containing 3 2 2
MIRT463178 ZNF281 zinc finger protein 281 2 2
MIRT466606 TBC1D13 TBC1 domain family member 13 2 2
MIRT467235 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT471039 PISD phosphatidylserine decarboxylase 2 10
MIRT471892 NUAK2 NUAK family kinase 2 2 2
MIRT474151 LIMA1 LIM domain and actin binding 1 2 6
MIRT474155 LIFR LIF receptor alpha 2 2
MIRT481037 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT483083 GPR75 G protein-coupled receptor 75 2 4
MIRT485208 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT495187 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT495431 ATG7 autophagy related 7 2 2
MIRT499160 FAM83C family with sequence similarity 83 member C 2 6
MIRT499505 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 2 2
MIRT500400 ZMAT3 zinc finger matrin-type 3 2 10
MIRT500684 TRIM37 tripartite motif containing 37 2 2
MIRT501301 RPS6KB1 ribosomal protein S6 kinase B1 2 2
MIRT504339 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT505931 RCAN3 RCAN family member 3 2 4
MIRT513196 SLU7 SLU7 homolog, splicing factor 2 2
MIRT521807 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT522779 LAMP2 lysosomal associated membrane protein 2 2 6
MIRT530179 ZBED2 zinc finger BED-type containing 2 2 2
MIRT532397 SNX3 sorting nexin 3 2 2
MIRT532482 HOXA13 homeobox A13 2 2
MIRT532538 WDR13 WD repeat domain 13 2 2
MIRT534779 RAN RAN, member RAS oncogene family 2 2
MIRT535719 N4BP1 NEDD4 binding protein 1 2 2
MIRT539310 AKAP12 A-kinase anchoring protein 12 2 4
MIRT539877 RPL32 ribosomal protein L32 2 2
MIRT539891 IRGQ immunity related GTPase Q 2 2
MIRT540063 CEP104 centrosomal protein 104 2 2
MIRT540154 GTF2B general transcription factor IIB 2 4
MIRT540206 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT540391 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT540595 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 4
MIRT540733 FABP2 fatty acid binding protein 2 2 2
MIRT540949 SLC25A43 solute carrier family 25 member 43 2 2
MIRT541444 C18orf32 chromosome 18 open reading frame 32 2 4
MIRT541571 ZNF43 zinc finger protein 43 2 4
MIRT541601 ALOX15 arachidonate 15-lipoxygenase 2 2
MIRT541933 ORC1 origin recognition complex subunit 1 2 4
MIRT542394 WDR12 WD repeat domain 12 2 2
MIRT542414 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT542481 APOC3 apolipoprotein C3 2 2
MIRT542621 XIAP X-linked inhibitor of apoptosis 2 2
MIRT542976 FAM83F family with sequence similarity 83 member F 2 2
MIRT543741 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT544594 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT546441 SNX5 sorting nexin 5 2 2
MIRT548213 FKBP1A FK506 binding protein 1A 2 2
MIRT550471 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT555230 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 4
MIRT555428 PPAP2B phospholipid phosphatase 3 2 2
MIRT556368 MAF MAF bZIP transcription factor 2 2
MIRT558149 ELK4 ELK4, ETS transcription factor 2 2
MIRT566181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT568468 ARMC12 armadillo repeat containing 12 2 2
MIRT607594 TANGO2 transport and golgi organization 2 homolog 2 2
MIRT617588 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT621244 SIGLEC9 sialic acid binding Ig like lectin 9 2 4
MIRT623679 HOXD4 homeobox D4 2 2
MIRT625989 FGFR1OP FGFR1 oncogene partner 2 4
MIRT627244 ZBTB3 zinc finger and BTB domain containing 3 2 2
MIRT632946 ELOVL6 ELOVL fatty acid elongase 6 2 4
MIRT635872 SLC11A2 solute carrier family 11 member 2 2 2
MIRT636638 CHAF1B chromatin assembly factor 1 subunit B 2 2
MIRT643563 WDR73 WD repeat domain 73 2 2
MIRT647907 CIRH1A UTP4, small subunit processome component 2 2
MIRT652503 TMEM170A transmembrane protein 170A 2 2
MIRT652843 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT653299 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT659383 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT661339 TBC1D15 TBC1 domain family member 15 2 2
MIRT662372 ANKRD42 ankyrin repeat domain 42 2 2
MIRT664322 CD209 CD209 molecule 2 2
MIRT671759 F11R F11 receptor 2 2
MIRT673240 KLHDC8A kelch domain containing 8A 2 2
MIRT682871 C9orf156 tRNA methyltransferase O 2 2
MIRT683171 SF3A1 splicing factor 3a subunit 1 2 2
MIRT684262 TBXA2R thromboxane A2 receptor 2 2
MIRT684395 MCTS1 MCTS1, re-initiation and release factor 2 2
MIRT684883 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT686650 TMEM184C transmembrane protein 184C 2 2
MIRT687771 KIAA0355 KIAA0355 2 2
MIRT694352 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696347 SLC35D2 solute carrier family 35 member D2 2 2
MIRT700480 PUM1 pumilio RNA binding family member 1 2 2
MIRT705909 ADAM9 ADAM metallopeptidase domain 9 2 2
MIRT714076 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT714401 FBXO31 F-box protein 31 2 2
MIRT716442 RPS24 ribosomal protein S24 2 2
MIRT718204 PSMF1 proteasome inhibitor subunit 1 2 2
MIRT721238 CRCP CGRP receptor component 2 2
MIRT721271 SH3D19 SH3 domain containing 19 2 2
MIRT721603 ZNF484 zinc finger protein 484 2 2
MIRT722916 COA4 cytochrome c oxidase assembly factor 4 homolog 2 2
MIRT723457 CUL4A cullin 4A 2 2
MIRT733813 KREMEN1 kringle containing transmembrane protein 1 2 0
MIRT733814 CASK calcium/calmodulin dependent serine protein kinase 2 0
MIRT733815 KLF4 Kruppel like factor 4 2 0
MIRT733816 BCL2 BCL2, apoptosis regulator 2 0
MIRT733817 PCNA proliferating cell nuclear antigen 2 0
MIRT733818 BAX BCL2 associated X, apoptosis regulator 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-451b Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780CIS)
hsa-miR-451b Trastuzumab sensitive High HER2-Positive Breast Cancer tissue
hsa-mir-451b Cisplatin 5460033 NSC119875 approved sensitive cell line (CP20)
hsa-mir-451b Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-451b Neoadjuvant chemotherapy sensitive tissue (breast cancer)

Error report submission