miRTarBase - #MIRT198527


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pre-miRNA Information
pre-miRNA hsa-mir-1185-1   
Genomic Coordinates chr14: 101042977 - 101043062
Synonyms MIRN1185-1, hsa-mir-1185-1, MIR1185-1
Description Homo sapiens miR-1185-1 stem-loop
Comment This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1185-1-3p
Sequence 53| AUAUACAGGGGGAGACUCUUAU |74
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 14 + 101043033 29233923 MiREDiBase
A-to-I 7 14 + 101043035 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749794228 1 dbSNP
rs369414498 4 dbSNP
rs771096180 5 dbSNP
rs774958411 7 dbSNP
rs1226171972 11 dbSNP
rs1449899083 14 dbSNP
rs761183893 16 dbSNP
rs1380874583 20 dbSNP
rs771625921 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DSG2   
Synonyms CDHF5, HDGC
Description desmoglein 2
Transcript NM_001943   
Expression
Putative miRNA Targets on DSG2
3'UTR of DSG2
(miRNA target sites are highlighted)		 
>DSG2|NM_001943|3'UTR
   1 ACAGCAGTCAGCCACAAACTGACCCAGAGTTTAATTAGCAGTGACTAATTTCATGTTTCCAATGTACCTGATTTTTCATG
  81 AGCCTTACAGACACACAGAGACACATACACATTGATCTTAAAATTTTTCTCAGTCACTGATATGCAAAGGACCACACTGT
 161 CTCTGCTTCCAGGAGTATTTTAGAAATGTTCCACAATTTACTGAAGACATAGAGATGATGCTGCTGCTTAGGTGCCTTTT
 241 AGCAAGCTATGCAAACAATCCTGATAAAACAAGATACATAGAGAGTCAATCTGGCTTCTGAGAATTTACCAAGTGAACAG
 321 AGTACCTAGTTCATCAGCCGTCCAGTAAAGCAACCCAGGAAACTGACTGGGTCTCTTTGCCTACCGTATTAACATTAAAC
 401 ATTGATGTTCTGTATTCTGTACTTTACTGCACCCAGCAGACTTTCAACAACTCATTGATCCAAAGATACATGCACAGTCT
 481 GAGCACCAGCTATGGTGCTCATAACTTCTTTAAGACTTGAACCCTTTCAATCTGTGTGATTCATTAAATTGGACCATTGA
 561 TGATAAGAATACACATTGTATGTTTCTGTGCACATGACAGTGTGTGTGTGTGCACGTACATACTGTATAGTCTTAAAAAT
 641 AGCATTATACTGGCCAGGGGTGGTGGCTAACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCAACTGTG
 721 GTCAGGAGTTTGAGATCAGCCAGGCCAACCTGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGATG
 801 GTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCGGAGGTTGCAGTGAG
 881 CCGAGATCGCACCATTGCACTCCAGTCTGGGCAACAGAGTGAGATTCCGTCTCAAAAAAAAAAAGAAAAGGAAAAAAAAA
 961 TAGCATTATACCTCTTCCTTGTCTCAACCGCCATGAAAATTCTGAACACTCCAAATTCAGTTGAATAATCCAAAACAAAA
1041 TTTATAAGTATAAAATAATTTTACTTCTTATAGTAATAGTATACTTTAAAAAGCCTCAGGGTATATTATCTTCTAAACAG
1121 CTACAATTCAGTGCAGCTACATTAACCAACTATGTTCTCTAGTTGAGAACAACTAGGCCTATTTCACTGCTGTGTAGCCT
1201 CAGTGCCTAACATGGGTGCCAAATAAATATTCGTAGAATTACACTGAATTGTAAAAACCATTCGTTTTTGTTTACAATTG
1281 CCAAAAATCTCAAAAGGCCCTGTATTTATGTAATTCTTTGAAATTATTATTTTATTTTGATTTCTCAGTTATTGACTGGC
1361 TGGGTGTGACTTAGTACATAAGTACTCAATATTATAAAAACCTCAAATAATTGACTTGATTTTACACAACATCCTTCCCT
1441 TTTCTACAAGTTAATTTTTTTACAAATCATTTGGGTTATCTCCTAAATAGGTTATATTTTATTGCTTCTAGAAACAATGT
1521 TTCAAAATATATGTGCATTATCAGTAATAATTTGTATAAATATTTCCCACAACAATTTTCATAATTTTCAAAGACTAATT
1601 TCTTGACTGAAGATATTTTGCTAGGGAAGTGAAACTTTAAAATTTTGTAGATTTTAAAAAATATTGTTGAATGGTGTCAT
1681 GCAAAGGATTTATATAGTGTGCTCCCACTAACTGTACAGATCAGGACACATATTTTTAGACATCTAAGTCTGTAGCTTAA
1761 ATGGAGGTTACTCTTCCATCATCTAGAATTGTTTACTTAGTAATTGTTGTTTCTTTTATTATTATAGACTTACTATCAGT
1841 TTTATTTTGCCAAGTATGCAACAGGTATATCACTAGTATATGAAAATGTAAATATCACTTGTGTACTCAAACAAAAGTTG
1921 GTCTTAAGCTTCCACCTTGAGCAGCCTTGGAAACCTAACCTGCCTCTTTTAGCATAATCACATTTTCTAAATGATTTTCT
2001 TTGTTCCTGAAAAAGTGATTTGTATTAGTTTTACATTTGTTTTTTGGAAGATTATATTTGTATATGTATCATCATAAAAT
2081 ATTTAAATAAAAAGTATCTTTAGAGTGACCCTTTCCCCATAGATTTTTATTTCTCTATTATATTTTACAAGGAATATAAC
2161 TCAGTTTGTTAGGGAGAGTGCCTTAAAGGCAGGTGTTTCTTGGACTTTGTTATTTAATTAGATCTGCTTGCAATAAAAAA
2241 AGTTGTCGGTTATCTAAAATTCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaUUCUCAGAG-----GGGGACAUAua 5'
            || | ||||      ||||||||  
Target 5' ccAAAAATCTCAAAAGGCCCTGTATtt 3'
 1281 - 1307 140.00 -13.70
2 
miRNA  3' uauucucagaggggGACAUAUa 5'
                        ||||||| 
Target 5' tgtgcacgtacataCTGTATAg 3'
 609 - 630 140.00 -7.10
3 
miRNA  3' uaUUCUCAGAGGGGGACAUAUa 5'
            ||||  :| : ::|||||| 
Target 5' ggAAGA--TTATATTTGTATAt 3'
 2046 - 2065 136.00 -7.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
163229 3 ClinVar
326491 23 ClinVar
326492 97 ClinVar
326493 132 ClinVar
326494 160 ClinVar
326495 212 ClinVar
326496 239 ClinVar
326497 290 ClinVar
326498 301 ClinVar
326499 352 ClinVar
326500 393 ClinVar
326501 420 ClinVar
326502 423 ClinVar
326503 426 ClinVar
890819 505 ClinVar
326504 566 ClinVar
326505 599 ClinVar
326506 600 ClinVar
326507 609 ClinVar
890820 667 ClinVar
326508 678 ClinVar
326509 697 ClinVar
326510 706 ClinVar
326511 738 ClinVar
892056 740 ClinVar
326512 756 ClinVar
326513 789 ClinVar
892057 807 ClinVar
892058 848 ClinVar
326514 860 ClinVar
326515 875 ClinVar
326516 890 ClinVar
326517 933 ClinVar
326518 934 ClinVar
326519 934 ClinVar
326520 952 ClinVar
326521 990 ClinVar
326522 991 ClinVar
326523 1013 ClinVar
326524 1037 ClinVar
326525 1072 ClinVar
326526 1137 ClinVar
326527 1264 ClinVar
888593 1265 ClinVar
326528 1340 ClinVar
888594 1386 ClinVar
326529 1400 ClinVar
326530 1451 ClinVar
326531 1472 ClinVar
326532 1474 ClinVar
326533 1531 ClinVar
890295 1597 ClinVar
326534 1653 ClinVar
326535 1675 ClinVar
326536 1713 ClinVar
326537 1787 ClinVar
890296 1804 ClinVar
890297 1832 ClinVar
326538 1845 ClinVar
326539 1867 ClinVar
890860 1983 ClinVar
326540 2035 ClinVar
COSN30135949 5 COSMIC
COSN30503674 24 COSMIC
COSN30467678 26 COSMIC
COSN20079191 32 COSMIC
COSN28855623 47 COSMIC
COSN30472046 78 COSMIC
COSN30485981 120 COSMIC
COSN30115165 269 COSMIC
COSN5424358 350 COSMIC
COSN23578111 461 COSMIC
COSN20114854 613 COSMIC
COSN26779366 716 COSMIC
COSN9330636 898 COSMIC
COSN20114856 1049 COSMIC
COSN29944309 1390 COSMIC
COSN20114857 1716 COSMIC
COSN25914559 1838 COSMIC
COSN21740975 1983 COSMIC
COSN27470881 2164 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs183494886 3 dbSNP
rs763295447 8 dbSNP
rs1425119878 10 dbSNP
rs952548028 11 dbSNP
rs1343967051 12 dbSNP
rs886053717 23 dbSNP
rs376777933 24 dbSNP
rs778221328 26 dbSNP
rs764510173 28 dbSNP
rs569977829 29 dbSNP
rs1281986760 30 dbSNP
rs1395202508 31 dbSNP
rs757490212 44 dbSNP
rs1294402506 72 dbSNP
rs1305465482 73 dbSNP
rs1230040320 79 dbSNP
rs1424201257 91 dbSNP
rs886053718 97 dbSNP
rs1252296944 101 dbSNP
rs1015547854 120 dbSNP
rs188594554 123 dbSNP
rs1038386758 124 dbSNP
rs1177090586 131 dbSNP
rs146873880 132 dbSNP
rs1215855407 133 dbSNP
rs1212389816 138 dbSNP
rs997183562 144 dbSNP
rs1282632229 146 dbSNP
rs1468967204 152 dbSNP
rs886053719 160 dbSNP
rs1232362910 162 dbSNP
rs1311828903 168 dbSNP
rs976655894 176 dbSNP
rs1028210811 191 dbSNP
rs955455319 192 dbSNP
rs1188076244 196 dbSNP
rs1360448096 202 dbSNP
rs920934081 205 dbSNP
rs751138164 209 dbSNP
rs1430563829 210 dbSNP
rs1314247735 211 dbSNP
rs555912274 212 dbSNP
rs1376729588 214 dbSNP
rs1170831288 216 dbSNP
rs1455724720 218 dbSNP
rs1373456904 219 dbSNP
rs1421271550 220 dbSNP
rs1192836452 222 dbSNP
rs758662453 227 dbSNP
rs555035341 239 dbSNP
rs924954820 247 dbSNP
rs780607833 250 dbSNP
rs1206942949 252 dbSNP
rs1306106388 253 dbSNP
rs370838110 261 dbSNP
rs914973501 279 dbSNP
rs1234434833 280 dbSNP
rs780826192 280 dbSNP
rs560540301 287 dbSNP
rs541237335 290 dbSNP
rs747504155 301 dbSNP
rs928276301 307 dbSNP
rs539372574 312 dbSNP
rs916194455 316 dbSNP
rs1461496025 321 dbSNP
rs950331366 324 dbSNP
rs1045964786 326 dbSNP
rs939606869 329 dbSNP
rs1287833121 333 dbSNP
rs527681357 341 dbSNP
rs1383591205 350 dbSNP
rs886053720 352 dbSNP
rs1055353482 355 dbSNP
rs1461840138 358 dbSNP
rs1419961846 363 dbSNP
rs1355237310 368 dbSNP
rs768738370 371 dbSNP
rs895168373 376 dbSNP
rs1038439478 387 dbSNP
rs886053721 393 dbSNP
rs996884404 395 dbSNP
rs1456663666 407 dbSNP
rs776627848 411 dbSNP
rs1214721866 413 dbSNP
rs552933757 420 dbSNP
rs1337521952 422 dbSNP
rs886053722 423 dbSNP
rs192049697 426 dbSNP
rs1339352085 437 dbSNP
rs115419348 448 dbSNP
rs1259074427 449 dbSNP
rs1020754358 450 dbSNP
rs563281210 452 dbSNP
rs1015847802 462 dbSNP
rs1330364816 465 dbSNP
rs1000591634 471 dbSNP
rs530443827 475 dbSNP
rs1032062233 478 dbSNP
rs1205960544 479 dbSNP
rs748350822 480 dbSNP
rs11542764 483 dbSNP
rs1474755995 487 dbSNP
rs183352782 488 dbSNP
rs374265931 495 dbSNP
rs375448328 501 dbSNP
rs1237826086 504 dbSNP
rs139121154 505 dbSNP
rs1157683708 509 dbSNP
rs971678673 509 dbSNP
rs1342945545 515 dbSNP
rs1454967572 517 dbSNP
rs1352034472 518 dbSNP
rs1289086219 520 dbSNP
rs774296097 528 dbSNP
rs1241708317 545 dbSNP
rs981649536 550 dbSNP
rs1374540774 558 dbSNP
rs908726870 558 dbSNP
rs11542765 566 dbSNP
rs915025818 569 dbSNP
rs1321424703 571 dbSNP
rs547959071 575 dbSNP
rs566186644 576 dbSNP
rs1385599503 581 dbSNP
rs1290658310 584 dbSNP
rs1417973647 586 dbSNP
rs1356619736 588 dbSNP
rs966430131 589 dbSNP
rs920045929 592 dbSNP
rs1223740227 594 dbSNP
rs1304892190 595 dbSNP
rs1376214217 598 dbSNP
rs1198610109 599 dbSNP
rs1491095224 599 dbSNP
rs1491142110 600 dbSNP
rs200699729 600 dbSNP
rs202041444 600 dbSNP
rs36022761 600 dbSNP
rs778277130 600 dbSNP
rs886053723 600 dbSNP
rs1346692449 609 dbSNP
rs886053724 609 dbSNP
rs34761003 610 dbSNP
rs1272803641 612 dbSNP
rs1239941863 614 dbSNP
rs928135932 617 dbSNP
rs939512608 620 dbSNP
rs1208423216 621 dbSNP
rs1259391274 638 dbSNP
rs1049786957 642 dbSNP
rs891088263 649 dbSNP
rs943961708 651 dbSNP
rs1172314171 655 dbSNP
rs1475926412 667 dbSNP
rs533653605 670 dbSNP
rs1405077093 672 dbSNP
rs916822607 673 dbSNP
rs113622947 678 dbSNP
rs1000686240 686 dbSNP
rs773284085 697 dbSNP
rs1432517871 698 dbSNP
rs569998174 700 dbSNP
rs773692598 701 dbSNP
rs111635557 705 dbSNP
rs57112788 706 dbSNP
rs975755828 709 dbSNP
rs970356448 710 dbSNP
rs924279068 712 dbSNP
rs981701697 716 dbSNP
rs868688413 727 dbSNP
rs767211637 738 dbSNP
rs775624337 740 dbSNP
rs1338814217 742 dbSNP
rs1333724939 746 dbSNP
rs886053725 756 dbSNP
rs998009556 763 dbSNP
rs1345942300 764 dbSNP
rs1168994540 770 dbSNP
rs1028225080 780 dbSNP
rs1465511068 780 dbSNP
rs889691943 787 dbSNP
rs886053726 789 dbSNP
rs1236798387 790 dbSNP
rs1010567738 791 dbSNP
rs1021918983 794 dbSNP
rs966374306 795 dbSNP
rs978263951 796 dbSNP
rs1312558210 797 dbSNP
rs1203640505 798 dbSNP
rs1231086674 799 dbSNP
rs1034757933 800 dbSNP
rs1438050661 801 dbSNP
rs1259684924 805 dbSNP
rs961192815 807 dbSNP
rs60921494 808 dbSNP
rs920079171 809 dbSNP
rs1354324097 817 dbSNP
rs916876487 819 dbSNP
rs1283746002 822 dbSNP
rs1443121380 822 dbSNP
rs1379416111 838 dbSNP
rs930886277 848 dbSNP
rs985909842 857 dbSNP
rs1167501633 859 dbSNP
rs886053727 860 dbSNP
rs907886692 864 dbSNP
rs944012646 865 dbSNP
rs1470279892 866 dbSNP
rs1175133400 867 dbSNP
rs1395376987 872 dbSNP
rs886053728 875 dbSNP
rs543256902 878 dbSNP
rs1409738565 883 dbSNP
rs1040881539 884 dbSNP
rs901912836 886 dbSNP
rs1223672762 889 dbSNP
rs886053729 890 dbSNP
rs1443600822 897 dbSNP
rs1325247744 898 dbSNP
rs934415712 900 dbSNP
rs1224429017 901 dbSNP
rs1368888780 902 dbSNP
rs1356075450 911 dbSNP
rs1443291201 914 dbSNP
rs549982586 918 dbSNP
rs1372174974 926 dbSNP
rs902465322 927 dbSNP
rs567754438 929 dbSNP
rs1361595596 930 dbSNP
rs886053730 933 dbSNP
rs1156441975 934 dbSNP
rs1227430919 934 dbSNP
rs1301555133 934 dbSNP
rs1438772338 934 dbSNP
rs368604939 934 dbSNP
rs886053731 934 dbSNP
rs936591258 941 dbSNP
rs1270665092 942 dbSNP
rs1192724032 943 dbSNP
rs1491047105 944 dbSNP
rs1309137116 946 dbSNP
rs1053633531 947 dbSNP
rs1216461067 949 dbSNP
rs1199212533 951 dbSNP
rs1489300580 952 dbSNP
rs200149790 952 dbSNP
rs886053732 952 dbSNP
rs894931690 952 dbSNP
rs889577310 953 dbSNP
rs1010785600 958 dbSNP
rs1195019410 959 dbSNP
rs906268895 960 dbSNP
rs1246907472 967 dbSNP
rs1022144294 969 dbSNP
rs1054179181 971 dbSNP
rs1402458157 972 dbSNP
rs1014595945 981 dbSNP
rs140755940 990 dbSNP
rs553112355 991 dbSNP
rs1359407679 993 dbSNP
rs1177923267 1003 dbSNP
rs886053733 1013 dbSNP
rs1027157506 1019 dbSNP
rs1424264460 1031 dbSNP
rs191443311 1037 dbSNP
rs866333378 1038 dbSNP
rs796564436 1043 dbSNP
rs960485976 1043 dbSNP
rs990531400 1045 dbSNP
rs538892613 1052 dbSNP
rs1463064171 1062 dbSNP
rs1208338441 1064 dbSNP
rs965416925 1069 dbSNP
rs1023820120 1070 dbSNP
rs183684674 1072 dbSNP
rs1339117009 1073 dbSNP
rs1344792567 1079 dbSNP
rs753354850 1082 dbSNP
rs1379316643 1089 dbSNP
rs1428918137 1102 dbSNP
rs1464285059 1106 dbSNP
rs1358358194 1108 dbSNP
rs908104723 1109 dbSNP
rs1363825446 1110 dbSNP
rs940715053 1116 dbSNP
rs756704492 1124 dbSNP
rs936593024 1133 dbSNP
rs764985189 1137 dbSNP
rs1192905931 1138 dbSNP
rs1054086494 1141 dbSNP
rs1258418780 1151 dbSNP
rs1180330454 1153 dbSNP
rs1292584287 1154 dbSNP
rs1233756293 1161 dbSNP
rs1200941465 1184 dbSNP
rs916428358 1185 dbSNP
rs1257949135 1187 dbSNP
rs1234493706 1190 dbSNP
rs947908475 1191 dbSNP
rs1314338916 1193 dbSNP
rs1393872881 1197 dbSNP
rs1378015969 1202 dbSNP
rs1331742312 1203 dbSNP
rs1448679338 1217 dbSNP
rs1397904038 1221 dbSNP
rs1169850660 1225 dbSNP
rs1046210348 1234 dbSNP
rs1162789793 1235 dbSNP
rs1423417497 1236 dbSNP
rs923388732 1237 dbSNP
rs188055604 1258 dbSNP
rs1214983878 1260 dbSNP
rs192887371 1264 dbSNP
rs115099821 1265 dbSNP
rs1210957087 1265 dbSNP
rs898794109 1276 dbSNP
rs995791689 1278 dbSNP
rs1489757920 1280 dbSNP
rs1027621641 1282 dbSNP
rs889634775 1298 dbSNP
rs1242019453 1303 dbSNP
rs954307249 1308 dbSNP
rs563449797 1310 dbSNP
rs1007496921 1311 dbSNP
rs750043090 1313 dbSNP
rs1478348843 1327 dbSNP
rs1043653674 1332 dbSNP
rs1387218511 1338 dbSNP
rs9304101 1340 dbSNP
rs1291822148 1364 dbSNP
rs1217638476 1367 dbSNP
rs999639738 1374 dbSNP
rs1457447752 1378 dbSNP
rs1056137783 1379 dbSNP
rs1476494610 1384 dbSNP
rs116439025 1386 dbSNP
rs185289967 1390 dbSNP
rs117440439 1400 dbSNP
rs952212058 1403 dbSNP
rs1200051281 1405 dbSNP
rs1320532914 1411 dbSNP
rs1265845639 1428 dbSNP
rs1209820224 1431 dbSNP
rs1490038717 1451 dbSNP
rs886053734 1451 dbSNP
rs1006379629 1454 dbSNP
rs1351067633 1455 dbSNP
rs958247819 1455 dbSNP
rs1278688799 1459 dbSNP
rs1233750153 1462 dbSNP
rs1332654940 1464 dbSNP
rs1346074988 1469 dbSNP
rs574977992 1472 dbSNP
rs886053735 1474 dbSNP
rs759125769 1480 dbSNP
rs781272494 1481 dbSNP
rs1353442040 1488 dbSNP
rs916508854 1501 dbSNP
rs1235082984 1504 dbSNP
rs1173414674 1512 dbSNP
rs947993518 1519 dbSNP
rs1198766004 1524 dbSNP
rs1478435080 1526 dbSNP
rs15668 1531 dbSNP
rs1195237900 1532 dbSNP
rs531272575 1534 dbSNP
rs764740048 1536 dbSNP
rs1283084190 1538 dbSNP
rs769731397 1539 dbSNP
rs927746608 1544 dbSNP
rs1285893835 1567 dbSNP
rs1254095092 1569 dbSNP
rs1222751267 1571 dbSNP
rs1488439549 1576 dbSNP
rs1210571925 1585 dbSNP
rs1341070008 1593 dbSNP
rs549396103 1597 dbSNP
rs539047442 1599 dbSNP
rs914646484 1603 dbSNP
rs1398191913 1604 dbSNP
rs1036091744 1609 dbSNP
rs898846167 1630 dbSNP
rs946587888 1636 dbSNP
rs1486908070 1637 dbSNP
rs1400423817 1645 dbSNP
rs886053736 1653 dbSNP
rs994940367 1656 dbSNP
rs1466553597 1666 dbSNP
rs1050078226 1672 dbSNP
rs115630812 1675 dbSNP
rs923731981 1685 dbSNP
rs1476544450 1698 dbSNP
rs1241077875 1699 dbSNP
rs1187810596 1701 dbSNP
rs1363798014 1703 dbSNP
rs1468655077 1704 dbSNP
rs1202824103 1712 dbSNP
rs1253750066 1712 dbSNP
rs1393613518 1713 dbSNP
rs397729601 1713 dbSNP
rs10645928 1714 dbSNP
rs373674247 1715 dbSNP
rs1338820772 1720 dbSNP
rs1284854765 1726 dbSNP
rs1338945331 1751 dbSNP
rs1450392255 1751 dbSNP
rs11542767 1763 dbSNP
rs1007136782 1764 dbSNP
rs1402972793 1765 dbSNP
rs1434371602 1767 dbSNP
rs1465625461 1768 dbSNP
rs1019750304 1772 dbSNP
rs935271968 1777 dbSNP
rs527949747 1783 dbSNP
rs886053737 1787 dbSNP
rs147816088 1804 dbSNP
rs1473548144 1806 dbSNP
rs999577123 1810 dbSNP
rs1373406399 1814 dbSNP
rs1458034853 1814 dbSNP
rs1239849748 1827 dbSNP
rs1416470276 1829 dbSNP
rs1290618552 1832 dbSNP
rs546796254 1832 dbSNP
rs1335156288 1836 dbSNP
rs16962096 1845 dbSNP
rs1314609234 1850 dbSNP
rs1044863110 1851 dbSNP
rs538462380 1858 dbSNP
rs1241227504 1861 dbSNP
rs1280821424 1862 dbSNP
rs887517162 1865 dbSNP
rs1329735604 1866 dbSNP
rs1047433 1867 dbSNP
rs1351000797 1868 dbSNP
rs575177870 1879 dbSNP
rs969717755 1883 dbSNP
rs1350503194 1886 dbSNP
rs182005449 1888 dbSNP
rs1250408121 1889 dbSNP
rs1439925147 1899 dbSNP
rs997791806 1902 dbSNP
rs1381868965 1904 dbSNP
rs1436620034 1905 dbSNP
rs1176564197 1908 dbSNP
rs554120617 1910 dbSNP
rs1469526633 1911 dbSNP
rs1247180811 1913 dbSNP
rs1184034440 1922 dbSNP
rs1044602491 1935 dbSNP
rs1449927935 1936 dbSNP
rs537110155 1937 dbSNP
rs1453944928 1941 dbSNP
rs543587572 1956 dbSNP
rs56844837 1961 dbSNP
rs1307472156 1965 dbSNP
rs1467374173 1967 dbSNP
rs1368799065 1969 dbSNP
rs1277104855 1975 dbSNP
rs927802124 1978 dbSNP
rs986087902 1982 dbSNP
rs1302003146 1983 dbSNP
rs1419876595 1989 dbSNP
rs564850170 2006 dbSNP
rs34771681 2010 dbSNP
rs968775066 2016 dbSNP
rs1408167365 2018 dbSNP
rs977873254 2034 dbSNP
rs886053738 2035 dbSNP
rs772002689 2039 dbSNP
rs1192847201 2040 dbSNP
rs930410053 2040 dbSNP
rs557264999 2043 dbSNP
rs1050550971 2052 dbSNP
rs1377005009 2063 dbSNP
rs1439613730 2065 dbSNP
rs578087599 2073 dbSNP
rs1284112794 2074 dbSNP
rs935134206 2075 dbSNP
rs1215404458 2092 dbSNP
rs1313142193 2097 dbSNP
rs1281168802 2101 dbSNP
rs568673727 2101 dbSNP
rs1345459719 2103 dbSNP
rs1056410885 2104 dbSNP
rs1400046579 2106 dbSNP
rs1341885332 2109 dbSNP
rs1286744796 2117 dbSNP
rs917828871 2120 dbSNP
rs1429673541 2121 dbSNP
rs1251139118 2126 dbSNP
rs751350922 2132 dbSNP
rs947737676 2141 dbSNP
rs1044751289 2147 dbSNP
rs148933057 2163 dbSNP
rs778804444 2163 dbSNP
rs4799574 2164 dbSNP
rs747102728 2164 dbSNP
rs887404306 2168 dbSNP
rs1468086351 2169 dbSNP
rs1449076 2174 dbSNP
rs777028124 2175 dbSNP
rs1036493212 2180 dbSNP
rs563919257 2181 dbSNP
rs893917262 2185 dbSNP
rs1259239046 2193 dbSNP
rs1221066208 2205 dbSNP
rs1319382467 2206 dbSNP
rs898011677 2209 dbSNP
rs1199252735 2212 dbSNP
rs998080553 2218 dbSNP
rs1024059375 2225 dbSNP
rs184734037 2226 dbSNP
rs1304332880 2229 dbSNP
rs969393776 2235 dbSNP
rs1405147664 2242 dbSNP
rs1791233 2246 dbSNP
rs550442270 2247 dbSNP
rs1007725383 2248 dbSNP
rs1021587174 2249 dbSNP
rs1424573992 2253 dbSNP
rs1416188966 2265 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 1829.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000261590.8 | 3UTR | UUUCAAAAUAUAUGUGCAUUAUCAGUAAUAAUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066415 TBK1 TANK binding kinase 1 2 4
MIRT073567 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT074516 USP1 ubiquitin specific peptidase 1 2 4
MIRT080576 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 6
MIRT086539 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT086547 MOB4 MOB family member 4, phocein 2 2
MIRT088684 EML4 echinoderm microtubule associated protein like 4 2 4
MIRT090811 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT095500 PURA purine rich element binding protein A 2 2
MIRT109530 KLHL15 kelch like family member 15 2 6
MIRT109807 ZFX zinc finger protein, X-linked 2 2
MIRT117888 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT120273 GSK3B glycogen synthase kinase 3 beta 2 4
MIRT149892 LDLR low density lipoprotein receptor 2 2
MIRT178475 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT193445 RORA RAR related orphan receptor A 2 2
MIRT198527 DSG2 desmoglein 2 2 2
MIRT226427 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT227669 SET SET nuclear proto-oncogene 2 2
MIRT320405 HOXA9 homeobox A9 2 2
MIRT407774 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT439228 ZMIZ1 zinc finger MIZ-type containing 1 1 1
MIRT439312 VAT1L vesicle amine transport 1 like 1 1
MIRT439421 TMOD1 tropomodulin 1 1 1
MIRT439446 TMEM104 transmembrane protein 104 1 1
MIRT439524 STIM2 stromal interaction molecule 2 1 1
MIRT439612 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 1 1
MIRT439997 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1 1
MIRT440017 PCSK1 proprotein convertase subtilisin/kexin type 1 1 1
MIRT440131 NCOA4 nuclear receptor coactivator 4 1 1
MIRT440311 LRRC1 leucine rich repeat containing 1 1 1
MIRT440475 IAPP islet amyloid polypeptide 1 1
MIRT440511 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1 1
MIRT440617 FOXA2 forkhead box A2 1 1
MIRT440666 FBXL16 F-box and leucine rich repeat protein 16 1 1
MIRT440705 ERO1LB endoplasmic reticulum oxidoreductase 1 beta 1 1
MIRT441007 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 1 1
MIRT441018 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441062 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT441209 ARCN1 archain 1 1 1
MIRT449461 HAT1 histone acetyltransferase 1 2 2
MIRT467104 SRI sorcin 2 2
MIRT468060 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT468476 SESN3 sestrin 3 2 4
MIRT473533 MAX MYC associated factor X 2 2
MIRT473852 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474711 KIF13A kinesin family member 13A 2 6
MIRT481665 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT485120 SF3B3 splicing factor 3b subunit 3 2 2
MIRT493055 MTFR1 mitochondrial fission regulator 1 2 2
MIRT504258 C1orf147 chromosome 1 open reading frame 147 2 4
MIRT504361 ARID1B AT-rich interaction domain 1B 2 4
MIRT505748 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT506298 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508442 ZNF608 zinc finger protein 608 2 4
MIRT512782 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT520447 TSPAN2 tetraspanin 2 2 4
MIRT522133 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522395 MYADM myeloid associated differentiation marker 2 4
MIRT523397 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 4
MIRT523938 E2F8 E2F transcription factor 8 2 4
MIRT524349 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524711 BRMS1L breast cancer metastasis-suppressor 1 like 2 4
MIRT525134 ZNF256 zinc finger protein 256 2 2
MIRT525710 DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 2 2
MIRT531264 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538844 BTG1 BTG anti-proliferation factor 1 2 2
MIRT541366 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT542093 KCNK10 potassium two pore domain channel subfamily K member 10 2 6
MIRT543770 RBM12B RNA binding motif protein 12B 2 4
MIRT543940 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545150 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545842 ZNF264 zinc finger protein 264 2 4
MIRT548057 GOLGA7 golgin A7 2 2
MIRT549242 ATXN1L ataxin 1 like 2 4
MIRT551829 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT552484 ZNF136 zinc finger protein 136 2 2
MIRT553663 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT554988 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT555760 PCTP phosphatidylcholine transfer protein 2 2
MIRT556923 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT564991 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT566458 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT566538 PANK3 pantothenate kinase 3 2 2
MIRT567732 DLX2 distal-less homeobox 2 2 2
MIRT570081 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571735 RNF11 ring finger protein 11 2 2
MIRT573529 MDM2 MDM2 proto-oncogene 2 2
MIRT574459 RPS16 ribosomal protein S16 2 2
MIRT574992 Phka1 phosphorylase kinase alpha 1 2 3
MIRT576349 Pxdn peroxidasin 2 2
MIRT610196 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612920 GPRIN3 GPRIN family member 3 2 2
MIRT615021 DUSP6 dual specificity phosphatase 6 2 2
MIRT623573 IRS1 insulin receptor substrate 1 2 2
MIRT624437 CASD1 CAS1 domain containing 1 2 2
MIRT628714 ZNF585A zinc finger protein 585A 2 2
MIRT639565 PCK1 phosphoenolpyruvate carboxykinase 1 2 4
MIRT641485 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641657 PAPOLG poly(A) polymerase gamma 2 2
MIRT642210 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT653010 STX7 syntaxin 7 2 2
MIRT656130 MSH6 mutS homolog 6 2 2
MIRT656893 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660130 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660855 AFAP1 actin filament associated protein 1 2 2
MIRT676843 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681473 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682253 RS1 retinoschisin 1 2 2
MIRT694296 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694401 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT705277 BACH1 BTB domain and CNC homolog 1 2 2
MIRT720833 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT735713 SIRT1 sirtuin 1 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-1185-1-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1185-1-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil sensitive tissue (myasthenia gravis)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-1185-1-3p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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