miRTarBase - #MIRT210595


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pre-miRNA Information
pre-miRNA hsa-mir-3689a   
Genomic Coordinates chr9: 134849487 - 134849564
Description Homo sapiens miR-3689a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3689a-5p
Sequence 10| UGUGAUAUCAUGGUUCCUGGGA |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs866098973 7 dbSNP
rs1203092136 8 dbSNP
rs1275806724 10 dbSNP
rs1264215348 13 dbSNP
rs1203436967 16 dbSNP
rs1170643534 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KBTBD8   
Synonyms TA-KRP, TAKRP
Description kelch repeat and BTB domain containing 8
Transcript NM_032505   
Expression
Putative miRNA Targets on KBTBD8
3'UTR of KBTBD8
(miRNA target sites are highlighted)		 
>KBTBD8|NM_032505|3'UTR
   1 ATGAGTAGCAGGCCTTAGTGCATCACTGGCATCTCATTCTTAGGAAACTTGTCTTTGATACAAAAGAGTGCTGACAGTAT
  81 TTCAGAAAGCTGAGAGAGTTTTATACATGGAAAATGGGTATGCTTAAAGATTGCAGGGTAGGGAGGGATTTTCCTTCATC
 161 CTTGTGACATTTCATTTCAGTAAGGAAAAGATAACAAAGTGCAATTATCAGCATTTTTTTTTCCTGGCATAAAATTAATC
 241 ATTTCATTTTATAATTTTGTGATAAATAGTAACTGAGGTACCAGATGAATCAGGACAACTATGCACTCTTATAAGAGCAT
 321 TTAGGGTATTATTGGGTAAAGACGTCTAAACTTGTTTGATGTGACTTTTAATTTTAAATACGGGTAACAATCTGAGGCAA
 401 TATCACTAGGACTTTAGCTGTGACCTCTCTAACACAGAGAAGCACTAACTTAGATCCTCATTCTTAATATTTATATGTAT
 481 CTATTTTTGTGTACTGTTTTCAAGTGTACTGAGATTTAAATGTGTTCTATTATTAGAGTAGATCGAAGAAAAAATTAGTC
 561 TCAGAAAGAGCTTTTAGTCTGATTGTTTCCATTTCCCATGTAATTTTAAGTTAAGCTAAAGTTTTAAAGTGGCAGTTTTC
 641 TGTCGATGACTTTTTCAAGTGCTAACACTGTCTCTTTTGTGAAAATCTGGAAAAGTGCTCATATTCACAGGTGGCTGGTG
 721 CTAGTCTAACTTAATTCATGTGTATAACTAGATGGATTTAAATGGTCTGAGCCTATGCCTATCTTTCAAATTGGTGTGGA
 801 TTTCATGGCCATAGTACTTTACCTGTTGAACTCTTGTGATTTCACAAGATTCTCTACTTATGTGATAGGAGGGTATGGCC
 881 AGTTATTCATCTAACTGGACTCAATCTTAGAATAGTAGGAACATTATACCCAGTTTGCACTAACATGGGCCATTTGTAGC
 961 CCAACCTTCTCTTCCATCTACCTGTCCATTCATTATTGGTACAAGGAAAGGTAACTTATTTCTCTTCTGCACAGAGCATA
1041 ATGTGAAGTTTTATACCTACTTTTAAAATTCTGCTTTCCAGAAACAAAATTCCTGCAGTGGTCTAATTTAATGTCTTTAA
1121 GTTTCATATTACAATTAAAACCTCATTTTTTTTTTCCATTTTTGCACTTAACAGTGATGAATACTTTTACGTTGGAATCC
1201 TCCTTCTAGCTGAAGGTGATTGAAAAGGAAAAGAGTGAGTGAACAGAACCATAGCTTTCTAGGTACTAAAGCATTTTTTG
1281 CATTTAACTGATGAAATTTCTAACAATCATCAGTTAGGAATATTAACATGAAGGATAAACCAACTTATTTGTATACCTAA
1361 GGCAGGCATTTGGATCAGTAACATGTTTTACTAAGCCTAGAGTAATTCGTAAAGGGTATAAGCATAGGACAGATTTTGCC
1441 CTCAATCACAATATTTGTATTCACTTGAAAGCAAACTGGCATGGTTCGTATTTTAAAAATCTTGCACAAATTGTAATGTG
1521 ATACTGTGAAACAAATTGAAAACATTGCCTCTTTGCATCACATACCTCGTTTTTCAGAAACTTTCCAAACTGCTTTACAT
1601 AGACCTCTACAAGTAGGGAATGTTTTCTGAAGCAGAAGTTAAAATGGACAGCATTTCTAGAATTAACATTTTAAAATCTA
1681 GTCTTAGCTAGATATGTGGTTTCTTCTTATTGGTGTTGATAGTATGTCTGTAATCTCTGTATAAACTTTGTCAACATTTT
1761 TACCTCCCCAGTTTTATCTTCTGTTTTGTTTTTGTTTTTATCATCATGATGTTTTGGAGTTATTACTGTGTATTTTAGAA
1841 ATCATTCTTTACAGTTTTGCATTGCTGAGGAGAGAGAAAAAACAATTTTTTTGCAAGAGATGTTCATGTAATTTATTTTT
1921 GAAAGCTTTGTTGAATAAGATTTCCTGCCGCTTTTTGACAATCTTGTGTATTTAGAAAAATGTATTACTTGAAAACATGA
2001 CATAGAACATTGAGTTAGCAATTTACATGGGCTGTATGTTATATAAGAGAATGACATACTGTGGCTAATTCAACAGTAGA
2081 TTTATTCTTTTAGCCTGCACAACAGTTGATCTTTTGGCTATGACAATTTGTATGGAGGGTACGATCTAAGTTAAGTGTGT
2161 CAAAAGCAAGGCTTAGGATTTGTTATGGGAGTAGAATATATATTGAATTTTGTATGAAGAACTATTTGTTTAAATTATAT
2241 AGCTGGGATATTTTGCCACTGTTAAAATGGATTCAGAAGAGGTCCTAGAAAAGTAAGATTAGTGACATGTGTGGGTTTAT
2321 ATTTAGATATTTAAGGTGCATTTTCATAGTGTGGTAAGACCTTAAGTAAAAGGCACAATGGGTACTACAGAATTAAAATG
2401 TAGGTCTAACATAATGCCAGTTCCACTTTAACTTTGTTTTTGCATTTGAAGAATGTATGTAGCACTTTCCTATATATTTG
2481 TCACACATTGAAAACTGGACTGGGTATAACTATGTTATAGGAAAGTAGAAATTGTATTCTTTATTTTCCATCTTTGTTTT
2561 CTGTTCTACAAAGTTGATGCTTAAGCATCAAGCTGATTTTATTGGTCATGAGAACAAATGGATGTGATCATGAAGGAATC
2641 AGATTCCCTATGTAAAGCAGTTTAAAATGGAATTCAATGTTCAGTGCTCAGGTATGTAGTAAGTACTGTAGTCCTGTGGG
2721 GGCAAATGTGTAGATATTTTTAAACATTTTGCCATAATTGCACAATTTTTTGCATTTTTACCTGATGTCATTGTTTCTTA
2801 TAATAAAACCTTTTCTGATTGAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aggGUCC-UUGGUA-----C--UAUAGUGu 5'
             |:|| ||| ||     |  ||||||| 
Target 5' ataCGGGTAACAATCTGAGGCAATATCACt 3'
 378 - 407 149.00 -10.90
2 
miRNA  3' aggguccUUGGUACUAUAGUGu 5'
                 || : | ||||:|| 
Target 5' tgtctttAAGTTTCATATTACa 3'
 1112 - 1133 131.00 -6.10
3 
miRNA  3' agGGUC--CUUG---GUACUAUAGUGu 5'
            || |  ||||   ::|||| |||| 
Target 5' taCCTGTTGAACTCTTGTGATTTCACa 3'
 820 - 846 130.00 -14.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN16302055 66 COSMIC
COSN18728118 95 COSMIC
COSN21087956 174 COSMIC
COSN29719712 223 COSMIC
COSN31530776 226 COSMIC
COSN30540453 268 COSMIC
COSN30174161 285 COSMIC
COSN1958139 322 COSMIC
COSN22338476 460 COSMIC
COSN31549193 546 COSMIC
COSN31609448 549 COSMIC
COSN26646812 565 COSMIC
COSN5539632 666 COSMIC
COSN1280154 675 COSMIC
COSN31513544 698 COSMIC
COSN28647598 745 COSMIC
COSN31513679 797 COSMIC
COSN31555850 807 COSMIC
COSN31485651 1018 COSMIC
COSN31597233 1100 COSMIC
COSN19420823 1122 COSMIC
COSN31534309 1156 COSMIC
COSN9558206 1293 COSMIC
COSN6773941 1368 COSMIC
COSN31528658 1401 COSMIC
COSN31514682 1410 COSMIC
COSN31521200 1514 COSMIC
COSN24230931 1594 COSMIC
COSN31536434 1738 COSMIC
COSN31540642 1772 COSMIC
COSN31543969 1773 COSMIC
COSN30161368 1795 COSMIC
COSN15834901 1851 COSMIC
COSN31594786 1893 COSMIC
COSN229082 1935 COSMIC
COSN31571574 2102 COSMIC
COSN8489507 2194 COSMIC
COSN22350447 2237 COSMIC
COSN7704910 2283 COSMIC
COSN31484228 2303 COSMIC
COSN31566123 2327 COSMIC
COSN6773942 2339 COSMIC
COSN19663759 2383 COSMIC
COSN20717318 2419 COSMIC
COSN31608251 2452 COSMIC
COSN31556553 2479 COSMIC
COSN14722466 2481 COSMIC
COSN20708941 2529 COSMIC
COSN31484611 2590 COSMIC
COSN8489508 2608 COSMIC
COSN26561712 2621 COSMIC
COSN26562430 2658 COSMIC
COSN15958866 2669 COSMIC
COSN31484627 2676 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs375668260 4 dbSNP
rs1453149489 5 dbSNP
rs781318422 6 dbSNP
rs1380188820 9 dbSNP
rs755431644 11 dbSNP
rs1394935296 12 dbSNP
rs1295754023 13 dbSNP
rs745936712 14 dbSNP
rs1225804125 18 dbSNP
rs770042177 19 dbSNP
rs1324665890 23 dbSNP
rs775647528 27 dbSNP
rs987379220 30 dbSNP
rs761690479 32 dbSNP
rs376178568 36 dbSNP
rs912771718 37 dbSNP
rs773202312 46 dbSNP
rs760996744 51 dbSNP
rs745851454 52 dbSNP
rs764209320 52 dbSNP
rs1422884642 53 dbSNP
rs1390485789 54 dbSNP
rs1426613679 56 dbSNP
rs1258215349 58 dbSNP
rs956482578 59 dbSNP
rs779419661 67 dbSNP
rs1182415025 69 dbSNP
rs1482628703 72 dbSNP
rs138334864 75 dbSNP
rs1285050743 82 dbSNP
rs538725352 85 dbSNP
rs1206853048 91 dbSNP
rs1451213663 95 dbSNP
rs989106806 99 dbSNP
rs1274300185 105 dbSNP
rs558663522 108 dbSNP
rs1342743391 117 dbSNP
rs1314028438 124 dbSNP
rs946384183 132 dbSNP
rs1043461994 138 dbSNP
rs1309941650 139 dbSNP
rs926362579 141 dbSNP
rs1255179476 148 dbSNP
rs1430580015 155 dbSNP
rs1370205511 156 dbSNP
rs937782312 160 dbSNP
rs1002636511 163 dbSNP
rs1460246780 170 dbSNP
rs1370023619 174 dbSNP
rs1165373594 186 dbSNP
rs1035811905 193 dbSNP
rs375604670 193 dbSNP
rs1183737464 195 dbSNP
rs1483152707 196 dbSNP
rs1250657394 197 dbSNP
rs1362549806 202 dbSNP
rs1056692341 205 dbSNP
rs896346920 208 dbSNP
rs879134339 210 dbSNP
rs1021573299 214 dbSNP
rs991727275 214 dbSNP
rs1244614227 219 dbSNP
rs1471447196 223 dbSNP
rs968589900 227 dbSNP
rs1158576919 230 dbSNP
rs1290236459 232 dbSNP
rs149606575 241 dbSNP
rs537897602 250 dbSNP
rs186993356 254 dbSNP
rs1388799590 269 dbSNP
rs907721700 271 dbSNP
rs935300809 276 dbSNP
rs1327479037 279 dbSNP
rs573887108 280 dbSNP
rs1394816580 287 dbSNP
rs192251184 295 dbSNP
rs763722097 296 dbSNP
rs954128564 300 dbSNP
rs559518302 301 dbSNP
rs1040263217 302 dbSNP
rs573102639 307 dbSNP
rs545108272 309 dbSNP
rs1355699178 311 dbSNP
rs1209640743 312 dbSNP
rs1020188968 316 dbSNP
rs898772606 318 dbSNP
rs931570810 320 dbSNP
rs956257507 321 dbSNP
rs1275276131 322 dbSNP
rs886779991 333 dbSNP
rs753012158 344 dbSNP
rs565012628 345 dbSNP
rs894206550 353 dbSNP
rs1392074533 359 dbSNP
rs1322441987 366 dbSNP
rs1012778115 367 dbSNP
rs1387271932 375 dbSNP
rs1156318923 379 dbSNP
rs1021434858 382 dbSNP
rs372931824 383 dbSNP
rs530515345 390 dbSNP
rs1384427746 391 dbSNP
rs536361860 399 dbSNP
rs1250353732 401 dbSNP
rs1166558210 406 dbSNP
rs1418107549 408 dbSNP
rs1464841688 414 dbSNP
rs1464792142 416 dbSNP
rs1165898925 422 dbSNP
rs550560670 423 dbSNP
rs967666735 446 dbSNP
rs1202273568 448 dbSNP
rs979089159 454 dbSNP
rs372161821 474 dbSNP
rs1232433291 476 dbSNP
rs1031511542 478 dbSNP
rs1333391940 480 dbSNP
rs937743725 484 dbSNP
rs956744480 492 dbSNP
rs991944143 500 dbSNP
rs1353557545 504 dbSNP
rs115385435 505 dbSNP
rs939880547 516 dbSNP
rs1189621872 519 dbSNP
rs1295212800 522 dbSNP
rs1036877962 523 dbSNP
rs1190275650 529 dbSNP
rs1443052820 530 dbSNP
rs942760111 542 dbSNP
rs547006521 544 dbSNP
rs931270695 545 dbSNP
rs1276449169 549 dbSNP
rs1049711247 550 dbSNP
rs1338550865 561 dbSNP
rs763548905 579 dbSNP
rs1341887812 580 dbSNP
rs889813643 582 dbSNP
rs1008712206 586 dbSNP
rs566710745 591 dbSNP
rs770785047 599 dbSNP
rs1372049976 602 dbSNP
rs1169581986 611 dbSNP
rs1189377969 612 dbSNP
rs1417880292 616 dbSNP
rs147306137 619 dbSNP
rs1473451029 620 dbSNP
rs1010406653 630 dbSNP
rs1021840532 634 dbSNP
rs1477262906 643 dbSNP
rs968949832 645 dbSNP
rs370334577 646 dbSNP
rs1306691063 660 dbSNP
rs1057185257 668 dbSNP
rs1229891743 682 dbSNP
rs894119511 691 dbSNP
rs1171840527 698 dbSNP
rs1292078559 699 dbSNP
rs552251643 701 dbSNP
rs1351842730 707 dbSNP
rs544723653 708 dbSNP
rs959087307 719 dbSNP
rs992287511 722 dbSNP
rs1406402488 736 dbSNP
rs1413740588 740 dbSNP
rs1376170727 741 dbSNP
rs13078632 745 dbSNP
rs1473600971 749 dbSNP
rs998643786 756 dbSNP
rs1181720283 765 dbSNP
rs1293664831 766 dbSNP
rs1328491026 767 dbSNP
rs1230903564 772 dbSNP
rs575189883 782 dbSNP
rs373091603 786 dbSNP
rs939812270 790 dbSNP
rs954775096 791 dbSNP
rs1008251641 818 dbSNP
rs1020050787 822 dbSNP
rs1330590785 828 dbSNP
rs537808226 835 dbSNP
rs1222785014 839 dbSNP
rs1228599663 848 dbSNP
rs1276927275 857 dbSNP
rs554962277 858 dbSNP
rs762617296 861 dbSNP
rs964049430 863 dbSNP
rs1394266153 870 dbSNP
rs975910775 883 dbSNP
rs77002487 886 dbSNP
rs1389378613 887 dbSNP
rs1158488581 894 dbSNP
rs1417502806 896 dbSNP
rs1427561494 899 dbSNP
rs1192037117 903 dbSNP
rs1315386941 905 dbSNP
rs543981114 916 dbSNP
rs112791213 923 dbSNP
rs931219376 924 dbSNP
rs1049657257 926 dbSNP
rs1211741528 930 dbSNP
rs889762066 931 dbSNP
rs1268145904 932 dbSNP
rs1214486151 937 dbSNP
rs536522372 956 dbSNP
rs1346260138 957 dbSNP
rs1219504337 961 dbSNP
rs1370711236 965 dbSNP
rs768887410 967 dbSNP
rs1041492862 976 dbSNP
rs908821791 981 dbSNP
rs1437824446 982 dbSNP
rs891875049 988 dbSNP
rs137994976 989 dbSNP
rs1177045634 997 dbSNP
rs1434412726 999 dbSNP
rs1394180655 1002 dbSNP
rs1021788016 1004 dbSNP
rs915572970 1008 dbSNP
rs904714513 1011 dbSNP
rs867386130 1012 dbSNP
rs1034612457 1020 dbSNP
rs1262383524 1022 dbSNP
rs1185908496 1023 dbSNP
rs573064205 1028 dbSNP
rs560770936 1039 dbSNP
rs1281728544 1041 dbSNP
rs1210300043 1053 dbSNP
rs545269658 1057 dbSNP
rs183520158 1061 dbSNP
rs1202919244 1072 dbSNP
rs904273019 1074 dbSNP
rs998675097 1075 dbSNP
rs776937422 1088 dbSNP
rs1263389483 1094 dbSNP
rs1343363576 1096 dbSNP
rs1025103419 1099 dbSNP
rs768257477 1104 dbSNP
rs1381429965 1118 dbSNP
rs1303508131 1120 dbSNP
rs1414336111 1121 dbSNP
rs575427579 1127 dbSNP
rs919742931 1129 dbSNP
rs1393067389 1132 dbSNP
rs1431375213 1137 dbSNP
rs1009242215 1146 dbSNP
rs1426666879 1146 dbSNP
rs148269192 1146 dbSNP
rs1188069853 1156 dbSNP
rs1455499552 1156 dbSNP
rs1174166476 1157 dbSNP
rs1017486930 1158 dbSNP
rs964393388 1164 dbSNP
rs1453145215 1165 dbSNP
rs1206915551 1169 dbSNP
rs1483580939 1172 dbSNP
rs1251175476 1174 dbSNP
rs1287251115 1183 dbSNP
rs996846180 1188 dbSNP
rs1027102714 1190 dbSNP
rs1232787058 1191 dbSNP
rs187444044 1192 dbSNP
rs773857445 1195 dbSNP
rs1220236828 1203 dbSNP
rs1410738213 1207 dbSNP
rs911149724 1208 dbSNP
rs1297406836 1209 dbSNP
rs1369207524 1217 dbSNP
rs1165608342 1221 dbSNP
rs1474580728 1233 dbSNP
rs1415102389 1238 dbSNP
rs371558949 1242 dbSNP
rs761330640 1247 dbSNP
rs766925857 1254 dbSNP
rs1250190704 1256 dbSNP
rs1304799212 1262 dbSNP
rs560916732 1263 dbSNP
rs1267890484 1266 dbSNP
rs1489731241 1266 dbSNP
rs762131990 1268 dbSNP
rs1236178232 1274 dbSNP
rs1213683989 1278 dbSNP
rs1332760013 1301 dbSNP
rs190717279 1303 dbSNP
rs1229182407 1305 dbSNP
rs1335417218 1314 dbSNP
rs1305970984 1322 dbSNP
rs1389427686 1323 dbSNP
rs1261972694 1326 dbSNP
rs946095114 1330 dbSNP
rs1326486540 1331 dbSNP
rs1460919140 1337 dbSNP
rs13075459 1341 dbSNP
rs749935843 1342 dbSNP
rs1160767266 1344 dbSNP
rs1470280613 1363 dbSNP
rs1362895655 1375 dbSNP
rs904662112 1380 dbSNP
rs1001708994 1390 dbSNP
rs1254091811 1396 dbSNP
rs1193483790 1404 dbSNP
rs1467537430 1407 dbSNP
rs560498228 1409 dbSNP
rs948424161 1410 dbSNP
rs1194103334 1425 dbSNP
rs1379601218 1426 dbSNP
rs1235768926 1442 dbSNP
rs532523781 1446 dbSNP
rs1303885944 1488 dbSNP
rs1014957554 1489 dbSNP
rs1156929667 1492 dbSNP
rs925729436 1498 dbSNP
rs934428824 1507 dbSNP
rs1024631787 1518 dbSNP
rs961360250 1524 dbSNP
rs993855046 1527 dbSNP
rs1454417652 1533 dbSNP
rs1164439851 1539 dbSNP
rs879742758 1539 dbSNP
rs1383679686 1543 dbSNP
rs1026704765 1557 dbSNP
rs952513920 1566 dbSNP
rs1392637723 1567 dbSNP
rs1467263340 1569 dbSNP
rs1396007987 1570 dbSNP
rs1052772728 1578 dbSNP
rs182543601 1589 dbSNP
rs1327008363 1593 dbSNP
rs911079237 1596 dbSNP
rs965311521 1601 dbSNP
rs1194577934 1610 dbSNP
rs1446485100 1613 dbSNP
rs1259825696 1617 dbSNP
rs568973874 1621 dbSNP
rs765749855 1632 dbSNP
rs1308452114 1635 dbSNP
rs1316967478 1663 dbSNP
rs913206977 1664 dbSNP
rs531852884 1684 dbSNP
rs1270882287 1686 dbSNP
rs1336573712 1693 dbSNP
rs1214029788 1697 dbSNP
rs375953104 1707 dbSNP
rs548419042 1712 dbSNP
rs1271836655 1716 dbSNP
rs1431468722 1722 dbSNP
rs1325282804 1729 dbSNP
rs1178901665 1742 dbSNP
rs1397366401 1755 dbSNP
rs937450093 1756 dbSNP
rs1433218721 1761 dbSNP
rs1055962668 1778 dbSNP
rs143566130 1779 dbSNP
rs1014492553 1783 dbSNP
rs1168991138 1784 dbSNP
rs1419742776 1799 dbSNP
rs1187380927 1800 dbSNP
rs1475377980 1800 dbSNP
rs1371349978 1804 dbSNP
rs1037040449 1805 dbSNP
rs1189735328 1807 dbSNP
rs1486098695 1827 dbSNP
rs1415877568 1828 dbSNP
rs1209060523 1829 dbSNP
rs1186765225 1831 dbSNP
rs1484561659 1833 dbSNP
rs1274938842 1852 dbSNP
rs533978304 1853 dbSNP
rs1215026855 1860 dbSNP
rs1026966802 1867 dbSNP
rs1267852438 1877 dbSNP
rs1166049827 1881 dbSNP
rs896798477 1885 dbSNP
rs1354334898 1886 dbSNP
rs1355595350 1886 dbSNP
rs553299942 1893 dbSNP
rs1026652368 1900 dbSNP
rs147138985 1903 dbSNP
rs867714321 1906 dbSNP
rs538803654 1907 dbSNP
rs566467497 1909 dbSNP
rs1409848217 1916 dbSNP
rs1365106796 1917 dbSNP
rs148599394 1935 dbSNP
rs369968176 1946 dbSNP
rs77322878 1950 dbSNP
rs965605902 1951 dbSNP
rs1186073814 1952 dbSNP
rs1290919997 1952 dbSNP
rs1473701718 1961 dbSNP
rs976665970 1962 dbSNP
rs879723443 1967 dbSNP
rs1204992064 1971 dbSNP
rs967330461 1975 dbSNP
rs1270771066 1976 dbSNP
rs1215547278 1978 dbSNP
rs188291077 1985 dbSNP
rs925633846 2011 dbSNP
rs925979965 2025 dbSNP
rs934293349 2028 dbSNP
rs1231015773 2029 dbSNP
rs1271964171 2031 dbSNP
rs988969693 2035 dbSNP
rs1441895041 2036 dbSNP
rs1365312162 2044 dbSNP
rs767736425 2050 dbSNP
rs1462492891 2056 dbSNP
rs554410537 2065 dbSNP
rs1393747101 2066 dbSNP
rs1162901341 2070 dbSNP
rs1458979382 2086 dbSNP
rs866310846 2088 dbSNP
rs1469425429 2093 dbSNP
rs142065526 2099 dbSNP
rs917402310 2101 dbSNP
rs1468871613 2103 dbSNP
rs1206445465 2120 dbSNP
rs757423629 2121 dbSNP
rs1271935019 2122 dbSNP
rs950278070 2123 dbSNP
rs539852934 2127 dbSNP
rs560375897 2137 dbSNP
rs898085446 2140 dbSNP
rs1284496374 2143 dbSNP
rs577133971 2156 dbSNP
rs1371628153 2160 dbSNP
rs781099344 2172 dbSNP
rs1187223580 2178 dbSNP
rs888135242 2185 dbSNP
rs1324515093 2186 dbSNP
rs1006618068 2188 dbSNP
rs930564103 2191 dbSNP
rs1048975895 2198 dbSNP
rs1018453419 2200 dbSNP
rs1158649832 2205 dbSNP
rs900967827 2213 dbSNP
rs1378186529 2215 dbSNP
rs1004215945 2225 dbSNP
rs35676967 2226 dbSNP
rs1454631341 2237 dbSNP
rs1016128238 2240 dbSNP
rs1191722431 2242 dbSNP
rs1486556162 2244 dbSNP
rs1242267696 2249 dbSNP
rs370984497 2251 dbSNP
rs569696371 2251 dbSNP
rs998428968 2258 dbSNP
rs78907856 2273 dbSNP
rs1173063510 2274 dbSNP
rs1235437962 2291 dbSNP
rs1355568382 2299 dbSNP
rs745866487 2301 dbSNP
rs1301861607 2307 dbSNP
rs967281500 2307 dbSNP
rs1310502805 2316 dbSNP
rs565698883 2327 dbSNP
rs1376766743 2331 dbSNP
rs562717434 2336 dbSNP
rs1269223890 2345 dbSNP
rs1428834451 2352 dbSNP
rs1377535579 2365 dbSNP
rs970170885 2367 dbSNP
rs1359503555 2369 dbSNP
rs978989172 2379 dbSNP
rs35498666 2380 dbSNP
rs398091522 2380 dbSNP
rs1347005953 2382 dbSNP
rs955744352 2387 dbSNP
rs1032996502 2388 dbSNP
rs1208663272 2389 dbSNP
rs988484492 2398 dbSNP
rs1282443720 2403 dbSNP
rs531842902 2404 dbSNP
rs958715319 2405 dbSNP
rs1485547219 2407 dbSNP
rs548653882 2421 dbSNP
rs991560961 2435 dbSNP
rs917329477 2438 dbSNP
rs1308621401 2445 dbSNP
rs950208395 2447 dbSNP
rs373852418 2450 dbSNP
rs17045718 2451 dbSNP
rs1294123182 2453 dbSNP
rs1188587014 2460 dbSNP
rs1414470838 2462 dbSNP
rs560245376 2475 dbSNP
rs7623808 2481 dbSNP
rs930878137 2489 dbSNP
rs1049319897 2493 dbSNP
rs1397505043 2495 dbSNP
rs907788138 2496 dbSNP
rs1434784681 2508 dbSNP
rs1419470382 2510 dbSNP
rs1317034220 2518 dbSNP
rs1343004000 2537 dbSNP
rs1254447967 2544 dbSNP
rs756374729 2549 dbSNP
rs1432493814 2557 dbSNP
rs1197960829 2562 dbSNP
rs1481188979 2564 dbSNP
rs1251223659 2569 dbSNP
rs17045726 2571 dbSNP
rs192136350 2573 dbSNP
rs1039412796 2579 dbSNP
rs900915601 2585 dbSNP
rs997978479 2586 dbSNP
rs1020118709 2587 dbSNP
rs150789041 2589 dbSNP
rs1231853278 2604 dbSNP
rs139211684 2613 dbSNP
rs1000092257 2622 dbSNP
rs537698402 2631 dbSNP
rs1000317369 2641 dbSNP
rs554605657 2647 dbSNP
rs1391045429 2650 dbSNP
rs184447783 2653 dbSNP
rs187755939 2658 dbSNP
rs1183600539 2661 dbSNP
rs1010339056 2676 dbSNP
rs553370783 2678 dbSNP
rs114707650 2680 dbSNP
rs974523465 2681 dbSNP
rs972145902 2685 dbSNP
rs1273840012 2698 dbSNP
rs1213182070 2699 dbSNP
rs546069875 2707 dbSNP
rs1262698137 2711 dbSNP
rs919401113 2717 dbSNP
rs952227170 2718 dbSNP
rs1192214978 2722 dbSNP
rs984609903 2729 dbSNP
rs1306039574 2731 dbSNP
rs1444416094 2734 dbSNP
rs562883846 2741 dbSNP
rs910805266 2752 dbSNP
rs1439495350 2762 dbSNP
rs1388022402 2764 dbSNP
rs749175132 2766 dbSNP
rs1454002390 2768 dbSNP
rs940637835 2772 dbSNP
rs534701390 2782 dbSNP
rs1401983095 2788 dbSNP
rs1254148792 2791 dbSNP
rs1193619888 2792 dbSNP
rs192441267 2797 dbSNP
rs1263946599 2801 dbSNP
rs922323289 2802 dbSNP
rs933718772 2803 dbSNP
rs1041508841 2804 dbSNP
rs950052380 2810 dbSNP
rs562170106 2820 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 84541.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aggGUCC-UUGGUA-----C--UAUAGUGu 5'
             |:|| ||| ||     |  ||||||| 
Target 5' auaCGGGUAACAAUCUGAGGCAAUAUCACu 3'
 		15 - 44
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 84541.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agggucCUUGGUACUAUAGUGu 5'
                ||: ||  ||||||| 
Target 5' caaucuGAGGCA--AUAUCACu 3'
 		4 - 23
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 84541.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000295568.4 | 3UTR | ACUUUUAAUUUUAAAUACGGGUAACAAUCUGAGGCAAUAUCACUAGGACUUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000295568.4 | 3UTR | ACUUUUAAUUUUAAAUACGGGUAACAAUCUGAGGCAAUAUCACUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000295568.4 | 3UTR | UAACAAUCUGAGGCAAUAUCACUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000295568.4 | 3UTR | ACUUUUAAUUUUAAAUACGGGUAACAAUCUGAGGCAAUAUCACUAGGACUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
45 hsa-miR-3689a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT112230 MDM4 MDM4, p53 regulator 2 2
MIRT188656 FAM76A family with sequence similarity 76 member A 2 2
MIRT200911 ZNF264 zinc finger protein 264 2 4
MIRT210595 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT299207 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT317524 SLC39A7 solute carrier family 39 member 7 2 2
MIRT355849 SGMS2 sphingomyelin synthase 2 2 4
MIRT443052 THRB thyroid hormone receptor beta 2 2
MIRT446631 SDC3 syndecan 3 2 2
MIRT449409 TRIM5 tripartite motif containing 5 2 2
MIRT463561 ZBTB39 zinc finger and BTB domain containing 39 2 6
MIRT465704 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT472688 MYCBP MYC binding protein 2 4
MIRT493287 LNPEP leucyl and cystinyl aminopeptidase 2 2
MIRT499338 RAB25 RAB25, member RAS oncogene family 2 2
MIRT501723 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT507977 BCL2L13 BCL2 like 13 2 4
MIRT511811 HDGF heparin binding growth factor 2 6
MIRT516711 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 2 4
MIRT527853 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT531286 SLC7A7 solute carrier family 7 member 7 2 2
MIRT531894 INVS inversin 2 8
MIRT536807 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT537807 EFNB2 ephrin B2 2 4
MIRT544335 LPGAT1 lysophosphatidylglycerol acyltransferase 1 2 2
MIRT547142 PGM3 phosphoglucomutase 3 2 2
MIRT547429 MED4 mediator complex subunit 4 2 2
MIRT563354 ZNF181 zinc finger protein 181 2 2
MIRT564849 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566426 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 2
MIRT572512 KIAA0232 KIAA0232 2 2
MIRT574682 HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2 2
MIRT608820 ONECUT3 one cut homeobox 3 2 6
MIRT608886 CLIC6 chloride intracellular channel 6 2 2
MIRT608959 GIMAP1 GTPase, IMAP family member 1 2 4
MIRT609012 HPS3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 2 2
MIRT641431 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT661841 ZNF587B zinc finger protein 587B 2 2
MIRT690651 RPF2 ribosome production factor 2 homolog 2 2
MIRT704619 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708714 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT710663 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 2
MIRT711260 TPCN2 two pore segment channel 2 2 2
MIRT714649 FSTL1 follistatin like 1 2 2
MIRT718518 COL19A1 collagen type XIX alpha 1 chain 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3689a Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-3689a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-3689a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-3689a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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