miRTarBase - #MIRT212035


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pre-miRNA Information
pre-miRNA hsa-mir-8066   
Genomic Coordinates chr4: 101240795 - 101240872
Description Homo sapiens miR-8066 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-8066
Sequence 48| CAAUGUGAUCUUUUGGAUGUA |68
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs931560390 4 dbSNP
rs1189907448 6 dbSNP
rs1347410735 8 dbSNP
rs1422871438 10 dbSNP
rs1281396192 14 dbSNP
rs1236502030 19 dbSNP
rs929291819 20 dbSNP
rs756482594 21 dbSNP
Putative Targets

Gene Information
Gene Symbol RAPGEF2   
Synonyms CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP
Description Rap guanine nucleotide exchange factor 2
Transcript NM_014247   
Expression
Putative miRNA Targets on RAPGEF2
3'UTR of RAPGEF2
(miRNA target sites are highlighted)		 
>RAPGEF2|NM_014247|3'UTR
   1 GGCACAGACTTTTCTGGAAGCAGAGCGAGCCACCTGAAAGGAGAGCACAAGAAGACGTCCTGAGCATTGGAGCCTTGGAA
  81 CTCACATTCTGAGGACGGTGGACCAGTTTGCCTCCTTCCCTGCCTTAAAAGCAGCATGGGGCTTCTTCTCCCCTTCTTCC
 161 TTTCCCCTTTGCATGTGAAATACTGTGAAGAAATTGCCCTGGCACTTTTCAGACTTTGTTGCTTGAAATGCACAGTGCAG
 241 CAATCTTCGAGCTCCCACTGTTGCTGCCTGCCACATCACACAGTATCATTCCAAATTCCAAGATCATCACAACAAGATGA
 321 TTCACTCTGGCTGCACTTCTCAATGCCTGGAAGGATTTTTTTTAATCTTCCTTTTAGATTTCAATCCAGTCCTAGCACTT
 401 GATCTCATTGGGATAATGAGAAAAGCTAGCCATTGAACTACTTGGGGCCTTTAACCCACCAAGGAAGACAAAGAAAAACA
 481 ATGAAATCCTTTGAGTACAGTGCTTGTCCACTTGTTTACAATGTCCTCCTTTTAAAAAAAAAAAATGAGTTTAAAGATTT
 561 TGTTCAGAGAGTAAATATATATCCATTTAATGATTACAGTATTATTTTAAACCTTAAGTAGGGTTGCCAGCCTGGTTTCT
 641 GAAAAACCAAATATGCCGGACAGGGTGTGGCCACACCAAGAAGACGGGAAGACCTGGCTTGTGACCCTGGCTTCCCATGT
 721 CCTTCTGGTCTCACCCGCGAAGTGCCCTATCCTGGAAGTATGAAATGTTAGCCAATTAATACCAAGACACCTCATCTGCT
 801 CCTTCCCCAGTGGATGGGGTTCTTCTGTAAAACTGTTTGCACATGGCCAGGGGAGGGAACTAGGACCCTTGTGTCCTGTC
 881 TGAGCCTTATGGAGGCAGGACGGTGTCATTGGCGGATGTGTCCTGCTCCATTGAGATGGATGGCAAACCCCATTTTTAAG
 961 TTATATTTCTTTGATTTTTGTTAATTTAGAGGTGTAGGTTTTGTTTTTTGTTTTTTTGTTTTTTTTTAAGAGAAACATTT
1041 ATAACTGGATAGCATTGCAGTGAAAGCAGCTTGGGATGTTGGAGCTAATGCCAGCTGTTTATACTGCTCTTTCAAGACAG
1121 CCTCCCTTTATTGAATTGGCATTAGGGAATAAACAAGCCTTTAAACGTGATAAAAGATCAAAAACCTGGTTAGACATGCC
1201 AGCCTTTGCAAGGCAGGTTAGTCACCAAAGACTAACCTCCAAGTGGCTTTATGGACGCTGCATATAGAGAAGGCCTAAGT
1281 GTAGCAACCATCTGCTCACAGCTGCTATTAACCCTATAATGACTGAAATGACCCCTCCACTCTATTTTTGTGTTGTTTTG
1361 CACAGACTCCGGAAAAGTGAAGGCTGCCAATCTGAGTAGTACTCAAATGTGAGGAACTGCTGGTCTTGGATTTTTTTTCC
1441 ATTAAATTCAGCTGATCATATTGATCAGTAGATAAACGTAAATAGCTTCAAATTTTAAAAGTGGAATTGCAGTGTTTTTT
1521 CACTGTATCAAACAATGTCAGTGCTTTATTTAATAATTCTCTTCTGTATCATGGCATTTGTCTACTTGCTTATTACATTG
1601 TCAATTATGCATTTGTAATTTTACATGTAATATGCATTATTTGCCAGTTTTATTATATAGGCTATGGACCTCATGTGCAT
1681 ATAGAAAGACAGAAATCTAGCTCTACCACAAGTTGCACAAATGTTATCTAAGCATTAAGTAATTGTAGAACATAGGACTG
1761 CTAATCTCAGTTCGCTCTGTGATGTCAAGTGCAGAATGTACAATTAACTGGTGATTTCCTCATACTTTTGATACTACTTG
1841 TACCTGTATGTCTTTTAGAAAGACATTGGTGGAGTCTGTATCCCTTTTGTATTTTTAATACAATAATTGTACATATTGGT
1921 TATATTTTTGTTGAAGATGGTAGAAATGTACTATGTTTATGCTTCTACATCCAGTTTGTACAAGCTGGAAAATAAATAAA
2001 TATAACATAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' augUAGGUUUUCUAGUGUAAc 5'
             ||:||:  |||||:||| 
Target 5' taaATTCAGCTGATCATATTg 3'
 1443 - 1463 150.00 -17.10
2 
miRNA  3' auGUAGGUUU----UCU--AGUGUAAc 5'
            |||: :|:    :||  ||||||| 
Target 5' agCATTGGAGCCTTGGAACTCACATTc 3'
 63 - 89 147.00 -8.20
3 
miRNA  3' auGUAGGUUUUC---UAGUGUAAc 5'
            ::||:|   |   ||:||||| 
Target 5' ttTGTCTACTTGCTTATTACATTg 3'
 1577 - 1600 131.00 -8.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30147054 8 COSMIC
COSN30168530 22 COSMIC
COSN30115634 26 COSMIC
COSN30503415 28 COSMIC
COSN31492243 40 COSMIC
COSN28883130 48 COSMIC
COSN15303003 60 COSMIC
COSN31481381 64 COSMIC
COSN31562269 88 COSMIC
COSN26440475 96 COSMIC
COSN17037331 121 COSMIC
COSN31604306 191 COSMIC
COSN2001730 242 COSMIC
COSN20100711 546 COSMIC
COSN20100712 546 COSMIC
COSN5558574 554 COSMIC
COSN28232775 854 COSMIC
COSN22923757 914 COSMIC
COSN20100718 1018 COSMIC
COSN20100717 1019 COSMIC
COSN30419033 1176 COSMIC
COSN29344648 1264 COSMIC
COSN27791896 1389 COSMIC
COSN5807839 1581 COSMIC
COSN5055053 1677 COSMIC
COSN9887474 1713 COSMIC
COSN9887476 1721 COSMIC
COSN21175466 1761 COSMIC
COSN7746067 1825 COSMIC
COSN15737589 1904 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs750369701 4 dbSNP
rs758395572 6 dbSNP
rs779809600 13 dbSNP
rs1319674657 14 dbSNP
rs746839102 15 dbSNP
rs754697516 19 dbSNP
rs780885553 21 dbSNP
rs370024514 24 dbSNP
rs769339285 27 dbSNP
rs1262882851 28 dbSNP
rs746156168 30 dbSNP
rs752004301 30 dbSNP
rs1475514760 32 dbSNP
rs772745644 33 dbSNP
rs915936288 34 dbSNP
rs1425895862 45 dbSNP
rs1316315951 57 dbSNP
rs571130565 60 dbSNP
rs1483791194 65 dbSNP
rs1454999869 74 dbSNP
rs947954924 75 dbSNP
rs941445355 81 dbSNP
rs537369719 87 dbSNP
rs556927096 97 dbSNP
rs1385205291 98 dbSNP
rs1160151101 102 dbSNP
rs1038450373 113 dbSNP
rs567497249 115 dbSNP
rs1379668400 117 dbSNP
rs1218838888 144 dbSNP
rs1446328468 151 dbSNP
rs906472733 158 dbSNP
rs897147911 161 dbSNP
rs994203198 185 dbSNP
rs1447860973 199 dbSNP
rs781287434 200 dbSNP
rs146843285 201 dbSNP
rs1477877769 205 dbSNP
rs748337803 209 dbSNP
rs1292905098 210 dbSNP
rs1248804580 211 dbSNP
rs1354787029 217 dbSNP
rs1281978518 222 dbSNP
rs553536604 222 dbSNP
rs1446646322 248 dbSNP
rs898879643 249 dbSNP
rs769905574 250 dbSNP
rs1397697487 252 dbSNP
rs1448188936 259 dbSNP
rs1303462981 295 dbSNP
rs573351772 302 dbSNP
rs1411520154 306 dbSNP
rs1028657486 309 dbSNP
rs1371171400 309 dbSNP
rs1375053554 324 dbSNP
rs1051549757 331 dbSNP
rs1411740237 336 dbSNP
rs1321770012 342 dbSNP
rs891346024 343 dbSNP
rs545488935 344 dbSNP
rs1007559151 356 dbSNP
rs1276375035 362 dbSNP
rs1018453031 364 dbSNP
rs1303666122 373 dbSNP
rs1279496121 376 dbSNP
rs968242692 377 dbSNP
rs1009142879 385 dbSNP
rs1000605731 389 dbSNP
rs1362841837 407 dbSNP
rs182315285 412 dbSNP
rs1406543254 414 dbSNP
rs956679930 421 dbSNP
rs1298253919 426 dbSNP
rs1343606298 427 dbSNP
rs991810024 429 dbSNP
rs967641963 434 dbSNP
rs1226140594 437 dbSNP
rs1025069019 441 dbSNP
rs3749464 442 dbSNP
rs1477649780 445 dbSNP
rs980693464 448 dbSNP
rs1202091503 449 dbSNP
rs1357589868 453 dbSNP
rs1463826655 470 dbSNP
rs1205840663 481 dbSNP
rs1188421792 483 dbSNP
rs1440021272 488 dbSNP
rs1033604050 489 dbSNP
rs555382079 496 dbSNP
rs1476408104 501 dbSNP
rs957469230 506 dbSNP
rs75449855 511 dbSNP
rs915897996 521 dbSNP
rs950025220 522 dbSNP
rs1220791772 523 dbSNP
rs111929580 528 dbSNP
rs1442868230 530 dbSNP
rs974108808 530 dbSNP
rs1328259515 533 dbSNP
rs11337410 534 dbSNP
rs1392765750 534 dbSNP
rs1491010844 534 dbSNP
rs201698554 534 dbSNP
rs397995972 534 dbSNP
rs558669086 534 dbSNP
rs75198168 534 dbSNP
rs77826575 534 dbSNP
rs918653689 535 dbSNP
rs1236850370 536 dbSNP
rs930062732 541 dbSNP
rs1456918330 544 dbSNP
rs1386101395 547 dbSNP
rs940619310 549 dbSNP
rs1310029783 555 dbSNP
rs1321090608 557 dbSNP
rs1328164032 558 dbSNP
rs1051067874 566 dbSNP
rs530359912 568 dbSNP
rs1445883939 570 dbSNP
rs1383622718 580 dbSNP
rs942924202 586 dbSNP
rs1356515311 597 dbSNP
rs1229606802 598 dbSNP
rs774227132 600 dbSNP
rs1040010100 605 dbSNP
rs1379060711 614 dbSNP
rs1158585324 617 dbSNP
rs904005638 619 dbSNP
rs759271512 621 dbSNP
rs774286476 622 dbSNP
rs1802981 628 dbSNP
rs1050630853 629 dbSNP
rs1482096425 631 dbSNP
rs892181909 637 dbSNP
rs1013754886 640 dbSNP
rs888883807 641 dbSNP
rs373383424 648 dbSNP
rs969493567 655 dbSNP
rs1449212700 657 dbSNP
rs1040065341 658 dbSNP
rs143078289 659 dbSNP
rs1378801957 660 dbSNP
rs760435598 661 dbSNP
rs559052465 665 dbSNP
rs1359028681 668 dbSNP
rs1297925601 684 dbSNP
rs971840206 686 dbSNP
rs919089904 687 dbSNP
rs1410068170 700 dbSNP
rs930076318 707 dbSNP
rs1033162599 710 dbSNP
rs987325003 712 dbSNP
rs912552837 717 dbSNP
rs1456476599 722 dbSNP
rs942701806 722 dbSNP
rs1215597661 725 dbSNP
rs528195865 730 dbSNP
rs1039747014 736 dbSNP
rs1013097728 737 dbSNP
rs1022981143 738 dbSNP
rs1333432183 750 dbSNP
rs1321207989 753 dbSNP
rs1052575781 760 dbSNP
rs892666754 776 dbSNP
rs971455481 780 dbSNP
rs1278011679 784 dbSNP
rs1286028308 788 dbSNP
rs1393591613 789 dbSNP
rs1349460922 791 dbSNP
rs1025173517 803 dbSNP
rs904847913 815 dbSNP
rs981372106 820 dbSNP
rs908582468 826 dbSNP
rs1478626927 828 dbSNP
rs1015892849 834 dbSNP
rs1192753673 834 dbSNP
rs961982529 835 dbSNP
rs1207990343 843 dbSNP
rs993416627 843 dbSNP
rs972416323 844 dbSNP
rs954732757 860 dbSNP
rs986887931 867 dbSNP
rs1316368607 870 dbSNP
rs1257651710 872 dbSNP
rs912614579 886 dbSNP
rs748194086 889 dbSNP
rs964139656 891 dbSNP
rs551029377 902 dbSNP
rs571221952 903 dbSNP
rs1386730641 904 dbSNP
rs544419027 911 dbSNP
rs763816997 914 dbSNP
rs1365256330 915 dbSNP
rs761724841 919 dbSNP
rs533804252 925 dbSNP
rs1402861519 929 dbSNP
rs910264348 932 dbSNP
rs1466170178 936 dbSNP
rs1379181491 939 dbSNP
rs925276792 945 dbSNP
rs936904464 951 dbSNP
rs1238713650 953 dbSNP
rs761368357 968 dbSNP
rs1180655900 971 dbSNP
rs771921206 973 dbSNP
rs1410053095 974 dbSNP
rs1237575040 975 dbSNP
rs1204584321 977 dbSNP
rs1347335960 985 dbSNP
rs914059166 993 dbSNP
rs1232948273 998 dbSNP
rs554509651 1004 dbSNP
rs1040055613 1005 dbSNP
rs1445136433 1009 dbSNP
rs200077320 1010 dbSNP
rs1374016761 1011 dbSNP
rs3840263 1011 dbSNP
rs397995973 1011 dbSNP
rs550891100 1011 dbSNP
rs1231558773 1012 dbSNP
rs1396267582 1012 dbSNP
rs949605755 1012 dbSNP
rs902890890 1015 dbSNP
rs1349198738 1017 dbSNP
rs201341186 1018 dbSNP
rs371580242 1018 dbSNP
rs1379790524 1019 dbSNP
rs368364479 1019 dbSNP
rs376247376 1019 dbSNP
rs904921489 1019 dbSNP
rs536478271 1020 dbSNP
rs1001915758 1028 dbSNP
rs186106746 1035 dbSNP
rs1013461944 1039 dbSNP
rs191006531 1043 dbSNP
rs767994654 1053 dbSNP
rs1252951773 1054 dbSNP
rs1002950371 1056 dbSNP
rs760365630 1068 dbSNP
rs1026676207 1074 dbSNP
rs1238645930 1075 dbSNP
rs954669380 1077 dbSNP
rs1307955406 1085 dbSNP
rs1431188560 1094 dbSNP
rs1015532551 1096 dbSNP
rs766004477 1100 dbSNP
rs1378039894 1101 dbSNP
rs1341959474 1102 dbSNP
rs1331809971 1105 dbSNP
rs56326234 1114 dbSNP
rs1009118063 1120 dbSNP
rs1360967572 1134 dbSNP
rs377541951 1137 dbSNP
rs961706003 1156 dbSNP
rs964086472 1160 dbSNP
rs975534129 1167 dbSNP
rs752988111 1168 dbSNP
rs1163976992 1170 dbSNP
rs1388176223 1180 dbSNP
rs958054199 1187 dbSNP
rs988392580 1196 dbSNP
rs1385915754 1203 dbSNP
rs370190164 1204 dbSNP
rs1214872526 1206 dbSNP
rs1488271104 1217 dbSNP
rs951999539 1220 dbSNP
rs1212099011 1228 dbSNP
rs79848010 1229 dbSNP
rs910423242 1244 dbSNP
rs1046965145 1246 dbSNP
rs944437046 1253 dbSNP
rs1040174761 1257 dbSNP
rs926794404 1258 dbSNP
rs1341481603 1267 dbSNP
rs1445919082 1269 dbSNP
rs1359887249 1282 dbSNP
rs1037444330 1284 dbSNP
rs1228278844 1288 dbSNP
rs1253187105 1291 dbSNP
rs1487614838 1297 dbSNP
rs1209528178 1308 dbSNP
rs1162686182 1324 dbSNP
rs1466378343 1330 dbSNP
rs1037809954 1332 dbSNP
rs924396258 1333 dbSNP
rs1192028952 1334 dbSNP
rs1477709075 1339 dbSNP
rs1247590575 1345 dbSNP
rs1201689376 1350 dbSNP
rs898819575 1351 dbSNP
rs1469656043 1353 dbSNP
rs934296461 1354 dbSNP
rs1190321352 1359 dbSNP
rs1054130026 1363 dbSNP
rs537842873 1371 dbSNP
rs1389507120 1372 dbSNP
rs1259573662 1374 dbSNP
rs544204449 1399 dbSNP
rs1802982 1410 dbSNP
rs1182563431 1415 dbSNP
rs1275178013 1417 dbSNP
rs1008819375 1420 dbSNP
rs1329251542 1424 dbSNP
rs1017447306 1431 dbSNP
rs1466200841 1431 dbSNP
rs1457087221 1439 dbSNP
rs900370085 1441 dbSNP
rs907402604 1442 dbSNP
rs1174654470 1471 dbSNP
rs1002901327 1478 dbSNP
rs1477349735 1478 dbSNP
rs1015604754 1479 dbSNP
rs540499437 1488 dbSNP
rs770629988 1504 dbSNP
rs1457832205 1507 dbSNP
rs560332341 1527 dbSNP
rs1395596381 1529 dbSNP
rs1196402751 1540 dbSNP
rs1443592705 1543 dbSNP
rs996919605 1545 dbSNP
rs576986396 1549 dbSNP
rs764525234 1557 dbSNP
rs995876920 1562 dbSNP
rs958166180 1565 dbSNP
rs1379255761 1569 dbSNP
rs34604884 1572 dbSNP
rs397879957 1572 dbSNP
rs1020960136 1585 dbSNP
rs1359931219 1585 dbSNP
rs1026995461 1590 dbSNP
rs952048046 1597 dbSNP
rs1336635509 1598 dbSNP
rs1426265118 1602 dbSNP
rs1424829023 1603 dbSNP
rs986087437 1605 dbSNP
rs1244248318 1609 dbSNP
rs1017432359 1614 dbSNP
rs1381647917 1614 dbSNP
rs1274058127 1618 dbSNP
rs1164168507 1619 dbSNP
rs1480126967 1626 dbSNP
rs556310097 1628 dbSNP
rs965838973 1636 dbSNP
rs971346827 1640 dbSNP
rs982423161 1644 dbSNP
rs975930263 1653 dbSNP
rs1206626176 1656 dbSNP
rs938207465 1662 dbSNP
rs1486143494 1663 dbSNP
rs973562339 1664 dbSNP
rs148204572 1665 dbSNP
rs1253461809 1673 dbSNP
rs929078099 1673 dbSNP
rs564817926 1675 dbSNP
rs79360309 1676 dbSNP
rs757835824 1677 dbSNP
rs1359148247 1685 dbSNP
rs1156372973 1687 dbSNP
rs1419607180 1689 dbSNP
rs1413806571 1690 dbSNP
rs1183272262 1697 dbSNP
rs781719306 1707 dbSNP
rs550283933 1712 dbSNP
rs560910185 1715 dbSNP
rs1454756972 1719 dbSNP
rs914280645 1727 dbSNP
rs1038997400 1728 dbSNP
rs1376993793 1731 dbSNP
rs530031095 1735 dbSNP
rs1214915952 1736 dbSNP
rs948953517 1746 dbSNP
rs900319287 1755 dbSNP
rs1294091754 1756 dbSNP
rs1000005919 1760 dbSNP
rs1226851028 1762 dbSNP
rs1355035010 1768 dbSNP
rs1279273793 1773 dbSNP
rs1267248852 1774 dbSNP
rs1339166796 1775 dbSNP
rs1288807207 1778 dbSNP
rs1458833862 1802 dbSNP
rs1349987544 1812 dbSNP
rs1032856694 1817 dbSNP
rs1459586623 1829 dbSNP
rs1416711543 1837 dbSNP
rs1194190709 1838 dbSNP
rs1317370019 1842 dbSNP
rs1044658763 1847 dbSNP
rs546874789 1859 dbSNP
rs907479419 1863 dbSNP
rs188113608 1867 dbSNP
rs938831387 1872 dbSNP
rs1267354549 1873 dbSNP
rs1037206507 1882 dbSNP
rs1334517436 1883 dbSNP
rs1254197094 1890 dbSNP
rs1220630510 1894 dbSNP
rs1338949332 1900 dbSNP
rs190708888 1906 dbSNP
rs182942531 1910 dbSNP
rs1370325524 1913 dbSNP
rs1294846276 1920 dbSNP
rs1438060414 1921 dbSNP
rs1393024998 1924 dbSNP
rs1320438991 1925 dbSNP
rs1170955819 1940 dbSNP
rs1259060824 1943 dbSNP
rs2049761 1944 dbSNP
rs1471397637 1948 dbSNP
rs749397276 1950 dbSNP
rs1169458177 1952 dbSNP
rs1433739763 1965 dbSNP
rs1269366417 1971 dbSNP
rs1407627441 1971 dbSNP
rs1468100905 1972 dbSNP
rs569237301 1972 dbSNP
rs1420062775 1974 dbSNP
rs1161853261 1982 dbSNP
rs982312861 1982 dbSNP
rs1027399066 1984 dbSNP
rs574556758 1985 dbSNP
rs959630311 1990 dbSNP
rs1377418806 2002 dbSNP
rs1314525531 2008 dbSNP
rs1299838908 2012 dbSNP
rs778834525 2015 dbSNP
rs187451775 2016 dbSNP
rs973508590 2022 dbSNP
rs920766879 2025 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000264431.4 | 3UTR | UCACAUUCUGAGGACGGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
92 hsa-miR-8066 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT060588 CCND1 cyclin D1 2 2
MIRT067440 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT078862 WBP2 WW domain binding protein 2 2 2
MIRT088062 UBXN2A UBX domain protein 2A 2 4
MIRT088214 NUP50 nucleoporin 50 2 2
MIRT103494 HOXA3 homeobox A3 2 8
MIRT135196 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT177727 REEP3 receptor accessory protein 3 2 2
MIRT179439 TBRG1 transforming growth factor beta regulator 1 2 4
MIRT191647 SLC39A9 solute carrier family 39 member 9 2 2
MIRT192342 KLF13 Kruppel like factor 13 2 2
MIRT212035 RAPGEF2 Rap guanine nucleotide exchange factor 2 2 2
MIRT215387 CREBRF CREB3 regulatory factor 2 2
MIRT235001 IER2 immediate early response 2 2 2
MIRT238793 TPD52L1 tumor protein D52 like 1 2 2
MIRT273384 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2 4
MIRT280473 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2 2
MIRT298320 SLC5A3 solute carrier family 5 member 3 2 2
MIRT309180 SPATA5 spermatogenesis associated 5 2 2
MIRT354483 LRRC58 leucine rich repeat containing 58 2 2
MIRT354710 SLC25A36 solute carrier family 25 member 36 2 2
MIRT361004 CDC5L cell division cycle 5 like 2 4
MIRT366247 VMA21 VMA21, vacuolar ATPase assembly factor 2 2
MIRT405774 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT442640 TBC1D12 TBC1 domain family member 12 2 2
MIRT443928 ZNF99 zinc finger protein 99 2 2
MIRT454287 FXN frataxin 2 2
MIRT454367 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT463574 ZBTB39 zinc finger and BTB domain containing 39 2 6
MIRT464484 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT466866 STX6 syntaxin 6 2 2
MIRT467283 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT470298 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT471630 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 2
MIRT472802 MTMR4 myotubularin related protein 4 2 4
MIRT474708 KIF3A kinesin family member 3A 2 2
MIRT478256 DDX3X DEAD-box helicase 3, X-linked 2 2
MIRT479330 CERS2 ceramide synthase 2 2 2
MIRT480658 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT481954 ANKRD11 ankyrin repeat domain 11 2 2
MIRT482895 IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog 2 4
MIRT493634 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT500847 SYPL1 synaptophysin like 1 2 4
MIRT502035 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT502185 IGSF3 immunoglobulin superfamily member 3 2 4
MIRT502605 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT502977 CCNL1 cyclin L1 2 8
MIRT504725 PLEKHA6 pleckstrin homology domain containing A6 2 10
MIRT504778 CLEC2D C-type lectin domain family 2 member D 2 4
MIRT505786 SATB1 SATB homeobox 1 2 4
MIRT510090 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 4
MIRT520010 YY1 YY1 transcription factor 2 4
MIRT532552 TXNL1 thioredoxin like 1 2 2
MIRT533433 TRPS1 transcriptional repressor GATA binding 1 2 2
MIRT537459 FAM84B family with sequence similarity 84 member B 2 2
MIRT541825 SV2B synaptic vesicle glycoprotein 2B 2 2
MIRT543222 TMEM117 transmembrane protein 117 2 2
MIRT551088 DDX52 DExD-box helicase 52 2 2
MIRT551500 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT552326 ZNF791 zinc finger protein 791 2 2
MIRT553213 TXLNG taxilin gamma 2 2
MIRT554590 RRAGC Ras related GTP binding C 2 2
MIRT559004 CA8 carbonic anhydrase 8 2 2
MIRT559134 BTG3 BTG anti-proliferation factor 3 2 4
MIRT559409 GDNF glial cell derived neurotrophic factor 2 4
MIRT560678 SRFBP1 serum response factor binding protein 1 2 2
MIRT560954 POTED POTE ankyrin domain family member D 2 2
MIRT562856 C17orf58 chromosome 17 open reading frame 58 2 2
MIRT563003 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT564545 CCDC80 coiled-coil domain containing 80 2 2
MIRT566272 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 2
MIRT566510 PAWR pro-apoptotic WT1 regulator 2 2
MIRT572103 EFNB2 ephrin B2 2 2
MIRT574576 NLGN4X neuroligin 4, X-linked 2 4
MIRT576574 Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 2 2
MIRT610815 POT1 protection of telomeres 1 2 2
MIRT624589 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT627567 SMAD6 SMAD family member 6 2 2
MIRT632675 MTX3 metaxin 3 2 2
MIRT689265 WDR83OS WD repeat domain 83 opposite strand 2 2
MIRT694310 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT697721 USP8 ubiquitin specific peptidase 8 2 2
MIRT700209 RFWD3 ring finger and WD repeat domain 3 2 2
MIRT704399 CTSS cathepsin S 2 2
MIRT710665 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 2
MIRT711953 SLC7A14 solute carrier family 7 member 14 2 2
MIRT712596 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT712692 TNFAIP2 TNF alpha induced protein 2 2 2
MIRT714171 PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 2 2
MIRT715964 CES4A carboxylesterase 4A 2 2
MIRT722781 PDE3A phosphodiesterase 3A 2 2
MIRT724505 MSMO1 methylsterol monooxygenase 1 2 2

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