pre-miRNA Information | |
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pre-miRNA | hsa-mir-3607 |
Genomic Coordinates | chr5: 86620497 - 86620575 |
Description | Homo sapiens miR-3607 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |
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Mature miRNA | hsa-miR-3607-3p |
Sequence | 51| ACUGUAAACGCUUUCUGAUG |70 |
Evidence | Experimental |
Experiments | Illumina |
Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | N4BP2 | ||||||||||||||||||||
Synonyms | B3BP | ||||||||||||||||||||
Description | NEDD4 binding protein 2 | ||||||||||||||||||||
Transcript | NM_018177 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on N4BP2 | |||||||||||||||||||||
3'UTR of N4BP2 (miRNA target sites are highlighted) |
>N4BP2|NM_018177|3'UTR 1 AATAAACATCCTTGAATTAGAAGTATGAAGGTTTGTAGGTTAAAATTACTTTTATTTGCAGTAATTCAGTCAATTCTACC 81 CTAAAGATGTGTTTTATTATAAATAATATTCAATTATGAAACAAAAAAATTATGATGTTTTTCAAAATGCAAGTGAGGTT 161 TGATTTTTTACTGAATCAAATGCAAATGTTACCTGTTAAAGATATTACAGAGAAATTTTATTGATTACAAAATATGTAAG 241 AAAATTATCAGCTACAGTTTTAAAGTTTAAAATGCTCTGATTGTTTCTCAGAAAAGGTTACCTTTGTATTAATTGTTGTA 321 TGACATTTAGTAATGTCCTAAAAGTCTTTTGTGAGAGGTATTTAAAGTGCTTTGAGACCTGATTCATGCCCCCCAAAGGG 401 TGGTATTAAAAGAGGAAAAAGGACATAGTAGTGGTAGTAAAGAAAAAAAGGAGATCTAACAAAAACACTTGAATATTTTT 481 TATTTTCAAAACTAAACACATAAAATGCTTTTATTTTGCCATATCCTACAGGAAGGAAGACATGCTTTTGCCCTTTCTTC 561 TGCTTTGTATATGACCTTGATCTTTTACCTTTTGTTCTGTTCTTCTGTGTGCATTTTATGGAAAGAAAGTTGGGTCTGAG 641 ATTATATTGTAATTTTATACTTTCTATAGACAGAAAGGTTTTCAGAGAAAAAGAAATGGTTAAATATCTTCCAGATGTTG 721 CTGCCTTATCGAAATGCTTCTAGAACTGTCTGTATAAGTCGTATTTCAGACAGTACTAAATACTTATATTTTATTTTTGA 801 GGCATGTAATTTTAAAACTGCAGTAGGTTAAAATTCTATTAAACAAATATAGAAAATATTTTGTTTATAATTGGCCTGGT 881 GTGGTGGCCCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTAGGTGGATCGCCTGAGGTCAGAAGTTCAAGACCAG 961 CCTGGCCAACATGGTGAATCCCCGTCTCTATTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGTGTGCCTGTAATCCCA 1041 GCTACTTGGGAGGCTGAGGCAGGAGAACCGCTTAAACCTGGGAGGTGGAGGTTGCAGTGACCCGAGATCGAGATCACACC 1121 ACTGCACTCAGCCTGGGTGACAGAGCAAGACTCCGTCTCCAAAAAAAAAAAAGAAAAAAAAGAGAAAATATTTTGGTTAT 1201 AATCATAAGAAGAATCCTTACAATTTAAAATATTTTCACTTTTATTTTGAAAAAGAGCCAACTTTCTCAAAGGAAGCTGT 1281 CATTAACTTCTGTTGTTTGGTTAGCTAATAAATTCTGTTAGTATGCAAGTTAAACCTGTGTAAAGGAGGTTATAATGTGG 1361 TAAGGTATAATTTTCCAATATGAGACAATGGCTTAAATTTGCCTTTGGAGATGGAGAATATTTTCAACATACATAATTTT 1441 AACAAATAGTTTTGTTGCTTTTTGTTAAGCTTAAAAAAAAATTTGGATCAGAAATTATAGGATTGAGCTGGTACCAAAAG 1521 AATCCTAAAGTACAGAATGGTTTTCCAAAAGAGCAGACATTTCAATGAAAATAAAACCCCAAAACATTTTTTTTATATAT 1601 CATGATTGCATGCTTTTAAAATAAGGAGGCTTATCATTGAATTTTAGTTCCATAAAAATGAAAATACATGTTTATTATTT 1681 AGAAATGGTTAGTGACTGGTATTGAAGTATTATTCACACTTATGTTTGTAATAATTTATTTAAAGAATGCCAACAGTTTA 1761 GCACACTTTTGTAATCTCTAGAACAGTTCTATACATTAAAAATAAACATTAAAAATAAAGCAGTTCCTTTAAACAACTTA 1841 CTATGAAACTATAATTGTTAATGAAATAAGATATTCCTATGTATACATTAGTATGATTTAAGGGTATGAAAAACAGTGCT 1921 AAAATGTGGAGTTAATTGGAATGTGTGCAGCTGCATACTCACTTTCTGTGTTTTTATATTTCCTTACCTAGTTTTAAAAA 2001 TCATCACTTTTCGGCACTTCAGCTAGACTTATTTCAATATTATAATTATGATTAATGAAGGAGCAGTCAGAAGTAGAGGT 2081 GTGGTATTCCGTGGGCAGAAGTCAAATGAAAAAAGCTATATTGTTTACTTGTTTACTATATCAATGTTAATATTATGCCT 2161 TATTTTGATAAATCAAATAGTATATCTTAATCATTGTTGATAAATATACAGGCAAAGTTTGAGCATCATATGTATTTTTA 2241 TGAAGCTGCTTAATTCCAAATTGCCTCCCACCCCACTATCTAGCATAGTTTAAGCAACACATAATTTTGAAAGAAAAGTT 2321 TGTAATCCCTCCTTTCTTTTTTTTGCCCATTTCTAAATCCTGTATGCCCGCAGTAAAGATAGTTTGGGGATTTTAAAAGT 2401 TTTCTCTATTACCCATTTCTAAATCCTGTATGTCAAAGATAGTTTGGAGATTATAAAAATTTTCATGTATTGGTGTAGGT 2481 TGAGTATCCCTAATGAGAAAATTCAAAATCTGAAATGCTTCAAAATCTGAAATTTTTCGAGCACAGACATGATGCTCAAA 2561 GGAAATACTCACAGAGCATTTTACATTTGTAGGTTAGCGATACTCAACAAGTAAATATAATGCACATGTTCTAAAATATC 2641 CCCCCAAACCCCAGCAATCCAAAACACTTCTGGTCCTAAGCATTTTGAGTAGGGGATACTCACTCAACCTGTATATTTGT 2721 GCTAATACATGACTCATTAGAATGATTCTTTGTAAACTTAATATTTTAAAAGTACAGCACTTCTGTAGTATGGAAGGTTT 2801 CAGTAATAATTATATTCATTCAGTAGTCTCTTACCATTATCTCCCAGATGGAAAAAGAGGACTAATGTGGAAACCCCAGA 2881 GGGTGTCCAGTTGGACCAGGGAGATATTAGACACTTAACAGTATTTTCAGTCTGTCCATCTCTTTATTCCAATGTGAGAA 2961 ATGGAAGTGTTTTTTTTTTTACGTTTATTGGCTCTTCATATTTCTCTACATTATTTTTAATGTGCAGTTTCTTCAATTGG 3041 TTAGTATTTCCATACTATTTGCAACTTTATGGCCTTTAAATATAGGACATATTATATAGCAGAAATTTTGACTTTAAATC 3121 CTCTTGAGTAGTATATTTTGAGAAGAAAAGCTATACTGCTCTTCTGGATGGTTTCCATCCTTTATTTAGGTCTTTTCTTT 3201 TTGAATTCAAGTGTTTTGTATGCTTAGAAAGTAGACATGTATAATATTGAGATCGGTTATTTCTGAGCTGGAAATTGGAA 3281 ACTTTGGAAACTCAGGAAATTGCTCTGACAATGTTTTAACTGCTCTCAATTTAAGAAAATGACGAAATGTATAAAAAAGA 3361 CAAAAATAACGTGTGCTGTTTTTTCCAAGTGCTTTTTCTAAGTGCTTTTCCATTGTGCAATGAGGTGAAGTTTGGTAATT 3441 TTTCGGTGTAGTAGTTAAATATTGCTCAATTTTTATTTACATGTAAAGAAAACAGATTTAAATGTTTATGTGGCCAAAAG 3521 GTGTCATTTAAAAGGTAAAATAAGTTTATGTAGAATGTATGTTCATGGTGCTTATTTTTAAAATGTAATTCAAGTTTACA 3601 GTATTACTTAATGCTTCTTTACAGAATTTAATAGAGAAACAAGGCTAGAACACATCTACATCCTGAAGAGCCGTTTATAA 3681 CTTCATATTATATGATGACAAAGTTCATTATTTTCCTTAAAGTTGAGCAATTGACTTTTATGGTCCAATGATGAACTTAT 3761 TATTAATAAATGATTGAGTTAACTGTGAGGCTTCTCATTAAAATACAATATTGCAGCTATCAGTTGGAGAATATATTATA 3841 AAATTTTCAGACAGTATATCAGAAAAATGTTTTTATTTGTACTGTATAGAAAATGTAATTTTGCTGTTAACTCTGTACTT 3921 TTTAAATTGAAAATGTTTTATAAATTTGCTTTTAAATTTTCTTATGAAGCCATTTGCAAATTACATACTTAATTTAATAA 4001 AATACTTTAGCCACAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | BC-1 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine
PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine
... - Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Gottwein E; Corcoran DL; Mukherjee N; et al. - Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
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CLIP-seq Support 1 for dataset GSM796037 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-1 / 4-Thiouridine |
Location of target site | ENST00000261435.6 | 3UTR | UCAAGUUUACAGUAUUACUUA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM796038 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-1 / 4-Thiouridine |
Location of target site | ENST00000261435.6 | 3UTR | UCAAGUUUACAGUAUUACUU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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93 hsa-miR-3607-3p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT057680 | LCOR | ligand dependent nuclear receptor corepressor | 2 | 2 | ||||||||
MIRT058092 | EIF4G2 | eukaryotic translation initiation factor 4 gamma 2 | 2 | 4 | ||||||||
MIRT063624 | FBXO28 | F-box protein 28 | 2 | 2 | ||||||||
MIRT071884 | BTF3L4 | basic transcription factor 3 like 4 | 2 | 2 | ||||||||
MIRT079440 | FOXK2 | forkhead box K2 | 2 | 4 | ||||||||
MIRT080491 | BCL10 | B-cell CLL/lymphoma 10 | 2 | 2 | ||||||||
MIRT081214 | MIDN | midnolin | 2 | 10 | ||||||||
MIRT082786 | ZNF264 | zinc finger protein 264 | 2 | 2 | ||||||||
MIRT082862 | ZNF543 | zinc finger protein 543 | 2 | 4 | ||||||||
MIRT099112 | FOXC1 | forkhead box C1 | 2 | 4 | ||||||||
MIRT099343 | QKI | QKI, KH domain containing RNA binding | 2 | 2 | ||||||||
MIRT100913 | CD2AP | CD2 associated protein | 2 | 2 | ||||||||
MIRT104030 | USP42 | ubiquitin specific peptidase 42 | 2 | 6 | ||||||||
MIRT130023 | QSER1 | glutamine and serine rich 1 | 2 | 2 | ||||||||
MIRT142614 | IL21R | interleukin 21 receptor | 2 | 2 | ||||||||
MIRT143477 | CHD9 | chromodomain helicase DNA binding protein 9 | 2 | 2 | ||||||||
MIRT187759 | ESYT1 | extended synaptotagmin 1 | 2 | 2 | ||||||||
MIRT200250 | EVI5 | ecotropic viral integration site 5 | 2 | 2 | ||||||||
MIRT212867 | N4BP2 | NEDD4 binding protein 2 | 2 | 2 | ||||||||
MIRT219622 | GIGYF1 | GRB10 interacting GYF protein 1 | 2 | 8 | ||||||||
MIRT220244 | FAM3C | family with sequence similarity 3 member C | 2 | 6 | ||||||||
MIRT222069 | PURB | purine rich element binding protein B | 2 | 2 | ||||||||
MIRT243478 | TRIM71 | tripartite motif containing 71 | 2 | 2 | ||||||||
MIRT261690 | PLEKHA1 | pleckstrin homology domain containing A1 | 2 | 2 | ||||||||
MIRT320184 | ITGB8 | integrin subunit beta 8 | 2 | 2 | ||||||||
MIRT441644 | CCNB1IP1 | cyclin B1 interacting protein 1 | 2 | 6 | ||||||||
MIRT441965 | BACE2 | beta-site APP-cleaving enzyme 2 | 2 | 2 | ||||||||
MIRT442175 | TRIM59 | tripartite motif containing 59 | 2 | 4 | ||||||||
MIRT442716 | TNKS | tankyrase | 2 | 2 | ||||||||
MIRT443932 | ZNF418 | zinc finger protein 418 | 2 | 2 | ||||||||
MIRT445790 | ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | 2 | 2 | ||||||||
MIRT448148 | P2RY10 | purinergic receptor P2Y10 | 2 | 2 | ||||||||
MIRT463393 | ZDHHC20 | zinc finger DHHC-type containing 20 | 2 | 2 | ||||||||
MIRT463761 | YPEL2 | yippee like 2 | 2 | 2 | ||||||||
MIRT477233 | ETF1 | eukaryotic translation termination factor 1 | 2 | 2 | ||||||||
MIRT483464 | DR1 | down-regulator of transcription 1 | 2 | 6 | ||||||||
MIRT484110 | ABCD2 | ATP binding cassette subfamily D member 2 | 2 | 4 | ||||||||
MIRT487297 | SLC38A9 | solute carrier family 38 member 9 | 2 | 2 | ||||||||
MIRT501292 | RRN3 | RRN3 homolog, RNA polymerase I transcription factor | 2 | 4 | ||||||||
MIRT501343 | RNF44 | ring finger protein 44 | 2 | 4 | ||||||||
MIRT502696 | CSNK1G1 | casein kinase 1 gamma 1 | 2 | 4 | ||||||||
MIRT511075 | NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 2 | 4 | ||||||||
MIRT511243 | KLHL36 | kelch like family member 36 | 2 | 6 | ||||||||
MIRT531418 | PLBD2 | phospholipase B domain containing 2 | 2 | 2 | ||||||||
MIRT536603 | IRF2 | interferon regulatory factor 2 | 2 | 2 | ||||||||
MIRT537727 | ELAVL2 | ELAV like RNA binding protein 2 | 2 | 2 | ||||||||
MIRT537985 | DPP8 | dipeptidyl peptidase 8 | 2 | 2 | ||||||||
MIRT539083 | ARNTL | aryl hydrocarbon receptor nuclear translocator like | 2 | 4 | ||||||||
MIRT547185 | PBRM1 | polybromo 1 | 2 | 2 | ||||||||
MIRT547596 | LIN28B | lin-28 homolog B | 2 | 2 | ||||||||
MIRT548188 | FOXA1 | forkhead box A1 | 2 | 2 | ||||||||
MIRT555055 | PYURF | PIGY upstream reading frame | 2 | 2 | ||||||||
MIRT557321 | HIC2 | HIC ZBTB transcriptional repressor 2 | 2 | 2 | ||||||||
MIRT557979 | FAM217B | family with sequence similarity 217 member B | 2 | 4 | ||||||||
MIRT558439 | DDIT4 | DNA damage inducible transcript 4 | 2 | 3 | ||||||||
MIRT558560 | CRLF3 | cytokine receptor like factor 3 | 2 | 4 | ||||||||
MIRT562332 | FGF2 | fibroblast growth factor 2 | 2 | 2 | ||||||||
MIRT565836 | SCML2 | Scm polycomb group protein like 2 | 2 | 2 | ||||||||
MIRT566796 | MIER3 | MIER family member 3 | 2 | 2 | ||||||||
MIRT568565 | AK4 | adenylate kinase 4 | 2 | 2 | ||||||||
MIRT572483 | PRR14L | proline rich 14 like | 2 | 2 | ||||||||
MIRT572586 | HGFAC | HGF activator | 2 | 2 | ||||||||
MIRT572876 | OPHN1 | oligophrenin 1 | 2 | 2 | ||||||||
MIRT573136 | ABT1 | activator of basal transcription 1 | 2 | 2 | ||||||||
MIRT573244 | ZBTB46 | zinc finger and BTB domain containing 46 | 2 | 2 | ||||||||
MIRT573388 | GGA2 | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | 2 | 2 | ||||||||
MIRT574588 | N4BP1 | NEDD4 binding protein 1 | 2 | 2 | ||||||||
MIRT575081 | Ddit4 | DNA-damage-inducible transcript 4 | 2 | 3 | ||||||||
MIRT609077 | SMIM15 | small integral membrane protein 15 | 2 | 8 | ||||||||
MIRT619337 | RNF2 | ring finger protein 2 | 2 | 2 | ||||||||
MIRT623058 | NRXN1 | neurexin 1 | 2 | 2 | ||||||||
MIRT623307 | MARCH4 | membrane associated ring-CH-type finger 4 | 2 | 2 | ||||||||
MIRT623899 | FOXN3 | forkhead box N3 | 2 | 2 | ||||||||
MIRT625177 | GRIK4 | glutamate ionotropic receptor kainate type subunit 4 | 2 | 2 | ||||||||
MIRT630448 | GTPBP8 | GTP binding protein 8 (putative) | 2 | 2 | ||||||||
MIRT630587 | SLC9A8 | solute carrier family 9 member A8 | 2 | 2 | ||||||||
MIRT634451 | PAK6 | p21 (RAC1) activated kinase 6 | 2 | 2 | ||||||||
MIRT634727 | CYP20A1 | cytochrome P450 family 20 subfamily A member 1 | 2 | 2 | ||||||||
MIRT635769 | PDCL3 | phosducin like 3 | 2 | 2 | ||||||||
MIRT650924 | ST6GALNAC1 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | 2 | 2 | ||||||||
MIRT668975 | CLSTN2 | calsyntenin 2 | 2 | 2 | ||||||||
MIRT669612 | AEBP2 | AE binding protein 2 | 2 | 2 | ||||||||
MIRT686746 | STX16 | syntaxin 16 | 2 | 2 | ||||||||
MIRT687932 | HMGN1 | high mobility group nucleosome binding domain 1 | 2 | 2 | ||||||||
MIRT691875 | GXYLT2 | glucoside xylosyltransferase 2 | 2 | 2 | ||||||||
MIRT698432 | TM4SF1 | transmembrane 4 L six family member 1 | 2 | 2 | ||||||||
MIRT698572 | TFDP2 | transcription factor Dp-2 | 2 | 2 | ||||||||
MIRT704500 | CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 2 | 2 | ||||||||
MIRT704907 | CCDC71L | coiled-coil domain containing 71 like | 2 | 2 | ||||||||
MIRT713810 | XRCC2 | X-ray repair cross complementing 2 | 2 | 2 | ||||||||
MIRT718300 | MOGAT1 | monoacylglycerol O-acyltransferase 1 | 2 | 2 | ||||||||
MIRT719022 | SHROOM3 | shroom family member 3 | 2 | 2 | ||||||||
MIRT723766 | MPLKIP | M-phase specific PLK1 interacting protein | 2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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