miRTarBase - #MIRT216690


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pre-miRNA Information
pre-miRNA hsa-mir-6733   
Genomic Coordinates chr1: 43171652 - 43171712
Description Homo sapiens miR-6733 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6733-5p
Sequence 6| UGGGAAAGACAAACUCAGAGUU |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs953882106 3 dbSNP
rs371499741 9 dbSNP
rs778441909 21 dbSNP
rs1348902205 22 dbSNP
Putative Targets

Gene Information
Gene Symbol F2R   
Synonyms CF2R, HTR, PAR-1, PAR1, TR
Description coagulation factor II thrombin receptor
Transcript NM_001992   
Expression
Putative miRNA Targets on F2R
3'UTR of F2R
(miRNA target sites are highlighted)		 
>F2R|NM_001992|3'UTR
   1 GAAAAGGGACTGCTGGGAGGTTAAAAAGAAAAGTTTATAAAAGTGAATAACCTGAGGATTCTATTAGTCCCCACCCAAAC
  81 TTTATTGATTCACCTCCTAAAACAACAGATGTACGACTTGCATACCTGCTTTTTATGGGAGCTGTCAAGCATGTATTTTT
 161 GTCAATTACCAGAAAGATAACAGGACGAGATGACGGTGTTATTCCAAGGGAATATTGCCAATGCTACAGTAATAAATGAA
 241 TGTCACTTCTGGATATAGCTAGGTGACATATACATACTTACATGTGTGTATATGTAGATGTATGCACACACATATATTAT
 321 TTGCAGTGCAGTATAGAATAGGCACTTTAAAACACTCTTTCCCCGCACCCCAGCAATTATGAAAATAATCTCTGATTCCC
 401 TGATTTAATATGCAAAGTCTAGGTTGGTAGAGTTTAGCCCTGAACATTTCATGGTGTTCATCAACAGTGAGAGACTCCAT
 481 AGTTTGGGCTTGTACCACTTTTGCAAATAAGTGTATTTTGAAATTGTTTGACGGCAAGGTTTAAGTTATTAAGAGGTAAG
 561 ACTTAGTACTATCTGTGCGTAGAAGTTCTAGTGTTTTCAATTTTAAACATATCCAAGTTTGAATTCCTAAAATTATGGAA
 641 ACAGATGAAAAGCCTCTGTTTTGATATGGGTAGTATTTTTTACATTTTACACACTGTACACATAAGCCAAAACTGAGCAT
 721 AAGTCCTCTAGTGAATGTAGGCTGGCTTTCAGAGTAGGCTATTCCTGAGAGCTGCATGTGTCCGCCCCCGATGGAGGACT
 801 CCAGGCAGCAGACACATGCCAGGGCCATGTCAGACACAGATTGGCCAGAAACCTTCCTGCTGAGCCTCACAGCAGTGAGA
 881 CTGGGGCCACTACATTTGCTCCATCCTCCTGGGATTGGCTGTGAACTGATCATGTTTATGAGAAACTGGCAAAGCAGAAT
 961 GTGATATCCTAGGAGGTAATGACCATGAAAGACTTCTCTACCCATCTTAAAAACAACGAAAGAAGGCATGGACTTCTGGA
1041 TGCCCATCCACTGGGTGTAAACACATCTAGTAGTTGTTCTGAAATGTCAGTTCTGATATGGAAGCACCCATTATGCGCTG
1121 TGGCCACTCCAATAGGTGCTGAGTGTACAGAGTGGAATAAGACAGAGACCTGCCCTCAAGAGCAAAGTAGATCATGCATA
1201 GAGTGTGATGTATGTGTAATAAATATGTTTCACACAAACAAGGCCTGTCAGCTAAAGAAGTTTGAACATTTGGGTTACTA
1281 TTTCTTGTGGTTATAACTTAATGAAAACAATGCAGTACAGGACATATATTTTTTAAAATAAGTCTGATTTAATTGGGCAC
1361 TATTTATTTACAAATGTTTTGCTCAATAGATTGCTCAAATCAGGTTTTCTTTTAAGAATCAATCATGTCAGTCTGCTTAG
1441 AAATAACAGAAGAAAATAGAATTGACATTGAAATCTAGGAAAATTATTCTATAATTTCCATTTACTTAAGACTTAATGAG
1521 ACTTTAAAAGCATTTTTTAACCTCCTAAGTATCAAGTATAGAAAATCTTCATGGAATTCACAAAGTAATTTGGAAATTAG
1601 GTTGAAACATATCTCTTATCTTACGAAAAAATGGTAGCATTTTAAACAAAATAGAAAGTTGCAAGGCAAATGTTTATTTA
1681 AAAGAGCAGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACGAGGTCAG
1761 GAGATCGAGACCATCCTGGCTAACACGGTGAAACCCGTCTCTACTAAAAATGCAAAAAAAATTAGCCGGGCGTGGTGGCA
1841 GGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGACTGGCGTGAACCCAGGAGGCGGACCTTGTAGTGAGCCG
1921 AGATCGCGCCACTGTGCTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAATAAAAATAAATAAAAAATAAAAAA
2001 ATAAAAGAGCAAACTATTTCCAAATACCATAGAATAACTTACATAAAAGTAATATAACTGTATTGTAAGTAGAAGCTAGC
2081 ACTGGTTTTATTAATTTAGTGACTATTCATTTTATCTAAATCAGTGAAGATTTACTGTCATTGTTTATTAGTCTGTATAT
2161 ATTAAAATATGATATCATTAATGTACTTACAAAATAGTATGTCACTGTTTTTATGTTCATTCTTAAAAACATAACCTGTA
2241 TTAATAAATGTGAACATTTGCTTGGTATCTCTTTGGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuGAGACUCAAACAGAAAGGGu 5'
            ||:| |     |||||||| 
Target 5' caCTTTAAAACACTCTTTCCCc 3'
 343 - 364 148.00 -11.94
2 
miRNA  3' uugAGACUCAAACA----GAAAGGGu 5'
             |:||:| ||||    ||||: | 
Target 5' tagTTTGGGCTTGTACCACTTTTGCa 3'
 480 - 505 117.00 -11.20
3 
miRNA  3' uugagAC-UCAAACAGAAAGggu 5'
               || ||  || |||||   
Target 5' gtgaaTGTAGGCTGGCTTTCaga 3'
 731 - 753 113.00 -6.62
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30520549 29 COSMIC
COSN7579947 44 COSMIC
COSN20086935 88 COSMIC
COSN30644586 93 COSMIC
COSN9957045 115 COSMIC
COSN26140248 135 COSMIC
COSN17181847 405 COSMIC
COSN25772257 534 COSMIC
COSN16353626 920 COSMIC
COSN16357591 930 COSMIC
COSN23150823 1117 COSMIC
COSN32058422 1164 COSMIC
COSN23995872 1194 COSMIC
COSN16236800 1525 COSMIC
COSN14942391 1619 COSMIC
COSN32188784 2009 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1325890921 5 dbSNP
rs1029509392 11 dbSNP
rs780116373 13 dbSNP
rs1266008685 18 dbSNP
rs371882526 21 dbSNP
rs1204949625 24 dbSNP
rs758362767 26 dbSNP
rs1263170262 29 dbSNP
rs777725871 30 dbSNP
rs768865391 34 dbSNP
rs746756476 37 dbSNP
rs760079347 38 dbSNP
rs780643564 40 dbSNP
rs376494894 44 dbSNP
rs2227800 45 dbSNP
rs1290004718 48 dbSNP
rs775176122 52 dbSNP
rs1394346295 53 dbSNP
rs151014270 62 dbSNP
rs1405337128 64 dbSNP
rs1454691445 66 dbSNP
rs1016530320 72 dbSNP
rs1233772417 83 dbSNP
rs1181079717 84 dbSNP
rs1358291366 85 dbSNP
rs140665593 86 dbSNP
rs967742054 104 dbSNP
rs1398958550 110 dbSNP
rs1242655573 119 dbSNP
rs1204384642 122 dbSNP
rs980444018 123 dbSNP
rs963205270 125 dbSNP
rs752798920 126 dbSNP
rs1033892691 130 dbSNP
rs763954114 140 dbSNP
rs751472124 142 dbSNP
rs1029028513 143 dbSNP
rs552152050 145 dbSNP
rs954750758 146 dbSNP
rs186599475 150 dbSNP
rs1381907252 152 dbSNP
rs1020520442 156 dbSNP
rs1317409681 162 dbSNP
rs1342870241 163 dbSNP
rs1240977816 176 dbSNP
rs371469192 178 dbSNP
rs1487448530 179 dbSNP
rs979011519 182 dbSNP
rs1160795226 188 dbSNP
rs919455506 190 dbSNP
rs1385147486 193 dbSNP
rs569367818 195 dbSNP
rs984926187 196 dbSNP
rs1413757321 199 dbSNP
rs548490232 202 dbSNP
rs1447773359 203 dbSNP
rs1286132179 208 dbSNP
rs916330854 219 dbSNP
rs1358712564 222 dbSNP
rs1315661985 227 dbSNP
rs909308433 234 dbSNP
rs943331678 237 dbSNP
rs1359283106 241 dbSNP
rs1378816823 247 dbSNP
rs1431066157 257 dbSNP
rs1039026226 270 dbSNP
rs767102995 275 dbSNP
rs1300499587 276 dbSNP
rs749869564 282 dbSNP
rs1313048375 286 dbSNP
rs933950803 291 dbSNP
rs755893650 298 dbSNP
rs1365273048 304 dbSNP
rs1164802905 323 dbSNP
rs1376884480 325 dbSNP
rs1051354862 329 dbSNP
rs886082729 332 dbSNP
rs1185970572 333 dbSNP
rs892340532 335 dbSNP
rs1373994149 338 dbSNP
rs1490126415 344 dbSNP
rs1393024582 349 dbSNP
rs1223742117 356 dbSNP
rs1305664083 358 dbSNP
rs1009726436 362 dbSNP
rs1043463861 365 dbSNP
rs779835348 366 dbSNP
rs1280983614 368 dbSNP
rs1403914721 374 dbSNP
rs568695638 377 dbSNP
rs1304105311 380 dbSNP
rs1459932032 392 dbSNP
rs1353263473 393 dbSNP
rs1033359585 396 dbSNP
rs556426580 411 dbSNP
rs569723649 412 dbSNP
rs755329288 414 dbSNP
rs1314130450 423 dbSNP
rs191397769 424 dbSNP
rs1008906435 428 dbSNP
rs1269381415 432 dbSNP
rs779322145 435 dbSNP
rs1020720907 438 dbSNP
rs183763206 446 dbSNP
rs372907246 448 dbSNP
rs187057192 452 dbSNP
rs1033256067 489 dbSNP
rs556564384 490 dbSNP
rs1180985104 495 dbSNP
rs1260655320 496 dbSNP
rs1236746124 499 dbSNP
rs964775858 500 dbSNP
rs1174652912 503 dbSNP
rs1426886961 513 dbSNP
rs1323770292 516 dbSNP
rs1470888287 520 dbSNP
rs576456187 533 dbSNP
rs748643980 534 dbSNP
rs542338855 539 dbSNP
rs772440377 540 dbSNP
rs917394638 546 dbSNP
rs756147509 550 dbSNP
rs1402610126 553 dbSNP
rs1174326201 554 dbSNP
rs933900621 557 dbSNP
rs879800461 559 dbSNP
rs1430226943 562 dbSNP
rs907542412 563 dbSNP
rs868205469 571 dbSNP
rs1177730077 572 dbSNP
rs1329296919 573 dbSNP
rs777948684 580 dbSNP
rs945192260 585 dbSNP
rs1461539038 611 dbSNP
rs1043598016 618 dbSNP
rs1236350895 621 dbSNP
rs1315540059 631 dbSNP
rs903577336 637 dbSNP
rs1241556013 638 dbSNP
rs1303373345 639 dbSNP
rs931843091 645 dbSNP
rs1370030874 653 dbSNP
rs1001983848 654 dbSNP
rs1452020791 657 dbSNP
rs111660890 671 dbSNP
rs1278010993 674 dbSNP
rs1308097711 676 dbSNP
rs1363065710 677 dbSNP
rs1159528362 680 dbSNP
rs896186414 689 dbSNP
rs1441545058 691 dbSNP
rs747088607 693 dbSNP
rs1383293540 699 dbSNP
rs1013677810 702 dbSNP
rs1256790163 708 dbSNP
rs1257611953 709 dbSNP
rs1026527178 710 dbSNP
rs1203030070 717 dbSNP
rs1485322796 720 dbSNP
rs554329048 727 dbSNP
rs113734071 729 dbSNP
rs1217789098 739 dbSNP
rs1194675740 749 dbSNP
rs1006313900 755 dbSNP
rs377230979 762 dbSNP
rs1476837727 764 dbSNP
rs1020333450 765 dbSNP
rs964745280 770 dbSNP
rs1314908939 773 dbSNP
rs974839321 784 dbSNP
rs758108065 785 dbSNP
rs1167879108 787 dbSNP
rs771201821 790 dbSNP
rs1000197474 791 dbSNP
rs1425169858 792 dbSNP
rs1033703697 795 dbSNP
rs865855371 806 dbSNP
rs989223086 814 dbSNP
rs34314266 815 dbSNP
rs1190391955 820 dbSNP
rs1327706031 828 dbSNP
rs1347835984 830 dbSNP
rs958956775 834 dbSNP
rs1013152254 842 dbSNP
rs1024482397 845 dbSNP
rs1274548473 845 dbSNP
rs776777444 851 dbSNP
rs535299274 853 dbSNP
rs1267380425 854 dbSNP
rs1225321103 874 dbSNP
rs1043567850 879 dbSNP
rs1220590947 883 dbSNP
rs982305045 893 dbSNP
rs1402037599 894 dbSNP
rs1276330422 895 dbSNP
rs907615765 900 dbSNP
rs962040399 904 dbSNP
rs777863192 905 dbSNP
rs973081569 919 dbSNP
rs925132590 933 dbSNP
rs540059283 935 dbSNP
rs41272244 940 dbSNP
rs1373109748 941 dbSNP
rs773993482 946 dbSNP
rs896227667 967 dbSNP
rs949056803 973 dbSNP
rs1214786758 975 dbSNP
rs532445928 976 dbSNP
rs1199148221 982 dbSNP
rs1047861955 985 dbSNP
rs761849970 986 dbSNP
rs1452756759 994 dbSNP
rs191179957 996 dbSNP
rs750007197 997 dbSNP
rs1016382602 1008 dbSNP
rs1194520000 1009 dbSNP
rs1338862516 1018 dbSNP
rs1221288230 1019 dbSNP
rs760202747 1030 dbSNP
rs1321636069 1031 dbSNP
rs1478584521 1039 dbSNP
rs182200038 1040 dbSNP
rs186981649 1045 dbSNP
rs1030379414 1049 dbSNP
rs954980124 1057 dbSNP
rs1326805886 1058 dbSNP
rs369580387 1065 dbSNP
rs1422237647 1068 dbSNP
rs1042232330 1090 dbSNP
rs988798998 1091 dbSNP
rs1467972225 1106 dbSNP
rs1428155720 1112 dbSNP
rs1000633032 1117 dbSNP
rs548336403 1118 dbSNP
rs1054480484 1127 dbSNP
rs1411521587 1133 dbSNP
rs1404623825 1134 dbSNP
rs1318694950 1136 dbSNP
rs1361471382 1146 dbSNP
rs1402033177 1160 dbSNP
rs1296422291 1168 dbSNP
rs894442622 1168 dbSNP
rs1459990661 1179 dbSNP
rs1013183495 1187 dbSNP
rs536801193 1189 dbSNP
rs966601064 1196 dbSNP
rs1346884876 1200 dbSNP
rs1277532199 1202 dbSNP
rs1024556146 1208 dbSNP
rs1233957835 1211 dbSNP
rs577274484 1213 dbSNP
rs1286533151 1219 dbSNP
rs527842551 1221 dbSNP
rs1404637132 1223 dbSNP
rs1334440009 1236 dbSNP
rs1415774349 1239 dbSNP
rs1354823484 1244 dbSNP
rs1228157903 1251 dbSNP
rs937788615 1253 dbSNP
rs990670457 1259 dbSNP
rs1157161538 1263 dbSNP
rs1439694428 1265 dbSNP
rs372229305 1274 dbSNP
rs766132440 1295 dbSNP
rs1442888020 1298 dbSNP
rs1236925599 1300 dbSNP
rs961832113 1303 dbSNP
rs1444308702 1312 dbSNP
rs1281966305 1320 dbSNP
rs949185062 1324 dbSNP
rs1261853135 1325 dbSNP
rs1354084411 1330 dbSNP
rs1311382354 1336 dbSNP
rs753504178 1343 dbSNP
rs1189019441 1344 dbSNP
rs1284254759 1352 dbSNP
rs1235708185 1361 dbSNP
rs557592863 1361 dbSNP
rs571049713 1361 dbSNP
rs2227801 1367 dbSNP
rs1158957353 1376 dbSNP
rs779386669 1378 dbSNP
rs1361524223 1388 dbSNP
rs2227802 1397 dbSNP
rs986043779 1399 dbSNP
rs1421763721 1402 dbSNP
rs1413213862 1410 dbSNP
rs1182511464 1415 dbSNP
rs1157138375 1416 dbSNP
rs942281192 1418 dbSNP
rs1193139348 1423 dbSNP
rs944565848 1428 dbSNP
rs1220228647 1431 dbSNP
rs1041538991 1433 dbSNP
rs1290053435 1438 dbSNP
rs924416858 1450 dbSNP
rs1396717516 1459 dbSNP
rs1336220615 1461 dbSNP
rs1037886016 1463 dbSNP
rs17568523 1468 dbSNP
rs1801719 1469 dbSNP
rs894514737 1477 dbSNP
rs1030930229 1487 dbSNP
rs1349791668 1491 dbSNP
rs890533568 1492 dbSNP
rs759010909 1513 dbSNP
rs1417418939 1517 dbSNP
rs1020282767 1519 dbSNP
rs1238414123 1523 dbSNP
rs2227803 1527 dbSNP
rs1348121335 1531 dbSNP
rs555415377 1532 dbSNP
rs1478259027 1541 dbSNP
rs572209910 1552 dbSNP
rs1197010291 1558 dbSNP
rs1201727727 1562 dbSNP
rs1488150312 1567 dbSNP
rs1247219613 1570 dbSNP
rs1223620819 1575 dbSNP
rs1253404988 1591 dbSNP
rs1256843400 1592 dbSNP
rs146680313 1597 dbSNP
rs376561509 1598 dbSNP
rs1280551400 1609 dbSNP
rs1319548796 1609 dbSNP
rs778130003 1613 dbSNP
rs575436918 1614 dbSNP
rs747106984 1614 dbSNP
rs1367265701 1615 dbSNP
rs1182360302 1618 dbSNP
rs1239917039 1620 dbSNP
rs1439168056 1621 dbSNP
rs533698594 1625 dbSNP
rs1330728691 1626 dbSNP
rs898617850 1626 dbSNP
rs1426035992 1632 dbSNP
rs1174475345 1634 dbSNP
rs994602293 1657 dbSNP
rs1379970757 1665 dbSNP
rs959289362 1677 dbSNP
rs1192900487 1680 dbSNP
rs557824052 1690 dbSNP
rs182799626 1691 dbSNP
rs1479599600 1692 dbSNP
rs990652213 1697 dbSNP
rs1174417669 1699 dbSNP
rs917763843 1700 dbSNP
rs1260867292 1702 dbSNP
rs1208943040 1704 dbSNP
rs1801718 1708 dbSNP
rs546104054 1709 dbSNP
rs1332699200 1710 dbSNP
rs562326391 1723 dbSNP
rs1308697462 1724 dbSNP
rs1447630755 1726 dbSNP
rs543727790 1729 dbSNP
rs1379758447 1734 dbSNP
rs985741452 1737 dbSNP
rs1334993977 1740 dbSNP
rs369278664 1742 dbSNP
rs1037350053 1743 dbSNP
rs1177958976 1746 dbSNP
rs1417301623 1748 dbSNP
rs922161933 1753 dbSNP
rs1179101830 1756 dbSNP
rs932265199 1757 dbSNP
rs975314820 1758 dbSNP
rs1234915148 1762 dbSNP
rs1051920854 1766 dbSNP
rs867426718 1767 dbSNP
rs1010411506 1768 dbSNP
rs1212669662 1772 dbSNP
rs1351891967 1779 dbSNP
rs1241444234 1785 dbSNP
rs768733633 1785 dbSNP
rs1259961627 1787 dbSNP
rs1456368693 1788 dbSNP
rs1395732831 1797 dbSNP
rs1042154170 1798 dbSNP
rs904626123 1801 dbSNP
rs541851864 1802 dbSNP
rs1304744611 1812 dbSNP
rs1359612548 1814 dbSNP
rs924477824 1814 dbSNP
rs546054294 1815 dbSNP
rs935826727 1822 dbSNP
rs1421422394 1824 dbSNP
rs1034377321 1828 dbSNP
rs564022321 1829 dbSNP
rs1424091051 1830 dbSNP
rs1012615629 1832 dbSNP
rs1024799827 1833 dbSNP
rs1262891404 1836 dbSNP
rs1376117074 1838 dbSNP
rs2227805 1841 dbSNP
rs1356458332 1843 dbSNP
rs1263813666 1844 dbSNP
rs983309240 1845 dbSNP
rs781232421 1848 dbSNP
rs536496348 1853 dbSNP
rs747662334 1855 dbSNP
rs1298554130 1863 dbSNP
rs1339652843 1863 dbSNP
rs1401844227 1864 dbSNP
rs1388473727 1865 dbSNP
rs548010162 1867 dbSNP
rs1457976091 1868 dbSNP
rs948731406 1871 dbSNP
rs1045777124 1874 dbSNP
rs907608749 1880 dbSNP
rs1464479658 1884 dbSNP
rs564731022 1888 dbSNP
rs1391832214 1889 dbSNP
rs963113996 1890 dbSNP
rs1388872751 1897 dbSNP
rs372812623 1898 dbSNP
rs377070938 1903 dbSNP
rs932250204 1904 dbSNP
rs550416761 1907 dbSNP
rs2227806 1908 dbSNP
rs1278669788 1910 dbSNP
rs1220251087 1912 dbSNP
rs1329072445 1913 dbSNP
rs570275605 1916 dbSNP
rs1027384601 1919 dbSNP
rs1387254853 1921 dbSNP
rs888851574 1924 dbSNP
rs946182655 1926 dbSNP
rs188268346 1927 dbSNP
rs774268507 1928 dbSNP
rs904595088 1929 dbSNP
rs1207838676 1934 dbSNP
rs966064497 1935 dbSNP
rs1265586694 1944 dbSNP
rs1000302704 1945 dbSNP
rs1198841416 1950 dbSNP
rs1451233660 1953 dbSNP
rs1434231520 1980 dbSNP
rs1269647566 1984 dbSNP
rs977399136 1984 dbSNP
rs1032002788 1988 dbSNP
rs1457327822 1988 dbSNP
rs957249405 1989 dbSNP
rs1055798947 1993 dbSNP
rs1273996657 1995 dbSNP
rs1332744824 1995 dbSNP
rs1369544375 1995 dbSNP
rs915716003 1996 dbSNP
rs948798346 1997 dbSNP
rs981487566 1998 dbSNP
rs1412375705 1999 dbSNP
rs894512771 1999 dbSNP
rs1172359183 2002 dbSNP
rs940010042 2002 dbSNP
rs1478678374 2003 dbSNP
rs1397448614 2004 dbSNP
rs1292124596 2006 dbSNP
rs1014263139 2007 dbSNP
rs1238817703 2008 dbSNP
rs1180789644 2027 dbSNP
rs1440905044 2030 dbSNP
rs1277726034 2042 dbSNP
rs1389595690 2043 dbSNP
rs1200835439 2046 dbSNP
rs1400185803 2051 dbSNP
rs1025274573 2054 dbSNP
rs1299501349 2059 dbSNP
rs149407515 2061 dbSNP
rs1239273849 2066 dbSNP
rs1005096465 2072 dbSNP
rs931511021 2076 dbSNP
rs1445449549 2081 dbSNP
rs1055222 2082 dbSNP
rs1014742407 2083 dbSNP
rs963079807 2087 dbSNP
rs1323400579 2101 dbSNP
rs565825695 2102 dbSNP
rs1242408138 2104 dbSNP
rs1334343795 2104 dbSNP
rs889928455 2106 dbSNP
rs796440284 2110 dbSNP
rs747878235 2117 dbSNP
rs534837182 2119 dbSNP
rs901548013 2127 dbSNP
rs921595989 2130 dbSNP
rs553660811 2136 dbSNP
rs1160357337 2140 dbSNP
rs998906987 2145 dbSNP
rs1237123929 2148 dbSNP
rs1031614397 2158 dbSNP
rs1486540228 2161 dbSNP
rs1260733116 2163 dbSNP
rs574272329 2169 dbSNP
rs953129389 2172 dbSNP
rs1011474476 2174 dbSNP
rs577000097 2184 dbSNP
rs1354963511 2187 dbSNP
rs1284457657 2189 dbSNP
rs1449705333 2203 dbSNP
rs1055227 2205 dbSNP
rs539270072 2207 dbSNP
rs1357814734 2208 dbSNP
rs1022809710 2211 dbSNP
rs1361748131 2231 dbSNP
rs543275531 2231 dbSNP
rs981559567 2234 dbSNP
rs1419943425 2237 dbSNP
rs1413100456 2243 dbSNP
rs928710861 2245 dbSNP
rs1476290830 2250 dbSNP
rs1421299823 2251 dbSNP
rs961426342 2261 dbSNP
rs973132787 2265 dbSNP
rs919909811 2266 dbSNP
rs1219233061 2268 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuGAGACUCAAACAGAAAGGGu 5'
            ||:| |     |||||||| 
Target 5' --CUUUAAAACACUCUUUCCC- 3'
 		1 - 19
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000319211.4 | 3UTR | CUUUAAAACACUCUUUCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
161 hsa-miR-6733-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT075325 SF3B3 splicing factor 3b subunit 3 2 4
MIRT082764 EPN1 epsin 1 2 4
MIRT119868 NRBP1 nuclear receptor binding protein 1 2 2
MIRT124577 PRRC2B proline rich coiled-coil 2B 2 2
MIRT126718 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT128925 KMT2A lysine methyltransferase 2A 2 2
MIRT135191 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT145630 LASP1 LIM and SH3 protein 1 2 2
MIRT175518 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT188406 ATXN7L3B ataxin 7 like 3B 2 2
MIRT192486 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT208383 SLC25A36 solute carrier family 25 member 36 2 2
MIRT216690 F2R coagulation factor II thrombin receptor 2 2
MIRT235839 FAM217B family with sequence similarity 217 member B 2 2
MIRT257000 RGMB repulsive guidance molecule family member b 2 2
MIRT266594 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT273614 SP1 Sp1 transcription factor 2 2
MIRT276567 AKAP11 A-kinase anchoring protein 11 2 2
MIRT285544 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT291540 LRRC8B leucine rich repeat containing 8 VRAC subunit B 2 2
MIRT317159 E2F3 E2F transcription factor 3 2 4
MIRT340688 THRAP3 thyroid hormone receptor associated protein 3 2 2
MIRT366934 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT376193 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT441983 TSTD2 thiosulfate sulfurtransferase like domain containing 2 2 2
MIRT442059 POU3F2 POU class 3 homeobox 2 2 6
MIRT443190 PDHA1 pyruvate dehydrogenase E1 alpha 1 subunit 2 2
MIRT445133 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT445881 WBP1L WW domain binding protein 1 like 2 2
MIRT449359 DPP6 dipeptidyl peptidase like 6 2 2
MIRT451399 FARSA phenylalanyl-tRNA synthetase alpha subunit 2 2
MIRT451802 CDCA3 cell division cycle associated 3 2 4
MIRT452295 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT452494 HMGXB3 HMG-box containing 3 2 2
MIRT453354 ZNF3 zinc finger protein 3 2 2
MIRT453375 CACNA2D2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 2 2
MIRT453719 RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 2 2
MIRT453839 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT454009 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT454371 PIGS phosphatidylinositol glycan anchor biosynthesis class S 2 2
MIRT454729 ARSK arylsulfatase family member K 2 2
MIRT455227 KIAA2013 KIAA2013 2 2
MIRT455866 SLC35C2 solute carrier family 35 member C2 2 2
MIRT456386 KLHL12 kelch like family member 12 2 2
MIRT457017 ACADSB acyl-CoA dehydrogenase, short/branched chain 2 2
MIRT457048 NEGR1 neuronal growth regulator 1 2 2
MIRT457402 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT457808 KLHL25 kelch like family member 25 2 2
MIRT458361 C3orf80 chromosome 3 open reading frame 80 2 2
MIRT458678 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT459629 GABARAP GABA type A receptor-associated protein 2 2
MIRT460955 MUL1 mitochondrial E3 ubiquitin protein ligase 1 2 2
MIRT462241 PRSS16 protease, serine 16 2 2
MIRT462472 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT462572 STS steroid sulfatase 2 2
MIRT462931 ZNF827 zinc finger protein 827 2 2
MIRT463442 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT464129 VPS35 VPS35, retromer complex component 2 2
MIRT464688 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465653 TNPO2 transportin 2 2 2
MIRT465951 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466032 TMEM189 transmembrane protein 189 2 2
MIRT466577 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467506 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 2
MIRT467786 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468104 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT468292 SFT2D2 SFT2 domain containing 2 2 2
MIRT469004 RNF41 ring finger protein 41 2 2
MIRT469753 RAB2B RAB2B, member RAS oncogene family 2 2
MIRT473205 MINK1 misshapen like kinase 1 2 4
MIRT473314 MEX3A mex-3 RNA binding family member A 2 2
MIRT473549 MAVS mitochondrial antiviral signaling protein 2 2
MIRT474269 LATS2 large tumor suppressor kinase 2 2 2
MIRT475111 IPPK inositol-pentakisphosphate 2-kinase 2 2
MIRT475436 HYOU1 hypoxia up-regulated 1 2 2
MIRT475751 HDLBP high density lipoprotein binding protein 2 2
MIRT475972 GTPBP2 GTP binding protein 2 2 2
MIRT476480 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT476595 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT476684 FURIN furin, paired basic amino acid cleaving enzyme 2 2
MIRT477261 ERGIC2 ERGIC and golgi 2 2 2
MIRT477647 EFNA1 ephrin A1 2 2
MIRT477790 E2F2 E2F transcription factor 2 2 2
MIRT477871 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT478012 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT479558 CDC5L cell division cycle 5 like 2 4
MIRT480420 C17orf85 nuclear cap binding subunit 3 2 2
MIRT480642 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT480778 BMP2 bone morphogenetic protein 2 2 2
MIRT481554 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT481689 AR androgen receptor 2 2
MIRT481836 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT483138 FOXC1 forkhead box C1 2 2
MIRT483919 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2 2
MIRT484202 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT484433 RAB7A RAB7A, member RAS oncogene family 2 4
MIRT485544 GP5 glycoprotein V platelet 2 2
MIRT486558 SLC38A4 solute carrier family 38 member 4 2 2
MIRT486727 MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2 4
MIRT490490 GLRA3 glycine receptor alpha 3 2 2
MIRT490682 SSTR1 somatostatin receptor 1 2 2
MIRT490792 PSMD3 proteasome 26S subunit, non-ATPase 3 2 2
MIRT491060 ACVR1B activin A receptor type 1B 2 4
MIRT492614 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT492768 PDGFB platelet derived growth factor subunit B 2 2
MIRT493988 EHD1 EH domain containing 1 2 2
MIRT494510 BDNF-AS BDNF antisense RNA 2 2
MIRT494755 AP3M2 adaptor related protein complex 3 mu 2 subunit 2 2
MIRT499802 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT501336 RNF44 ring finger protein 44 2 4
MIRT509490 CENPA centromere protein A 2 2
MIRT509643 ZNF354B zinc finger protein 354B 2 10
MIRT510147 PDGFRA platelet derived growth factor receptor alpha 2 4
MIRT510567 UNG uracil DNA glycosylase 2 6
MIRT525087 FRK fyn related Src family tyrosine kinase 2 2
MIRT528452 NXT2 nuclear transport factor 2 like export factor 2 2 4
MIRT531970 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT532084 RTTN rotatin 2 2
MIRT532756 LDHD lactate dehydrogenase D 2 2
MIRT535072 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT535637 NPEPPS aminopeptidase puromycin sensitive 2 2
MIRT545410 EIF4A3 eukaryotic translation initiation factor 4A3 2 4
MIRT545911 ZFP91 ZFP91 zinc finger protein 2 4
MIRT548007 GRB2 growth factor receptor bound protein 2 2 4
MIRT548545 DR1 down-regulator of transcription 1 2 2
MIRT550075 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT553730 TBRG1 transforming growth factor beta regulator 1 2 2
MIRT557569 GNPTAB N-acetylglucosamine-1-phosphate transferase alpha and beta subunits 2 2
MIRT558025 EXT1 exostosin glycosyltransferase 1 2 2
MIRT558139 ENC1 ectodermal-neural cortex 1 2 2
MIRT560173 COA1 cytochrome c oxidase assembly factor 1 homolog 2 2
MIRT561700 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT565101 UBE3C ubiquitin protein ligase E3C 2 2
MIRT565739 SESN3 sestrin 3 2 2
MIRT566669 NACC2 NACC family member 2 2 2
MIRT567040 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT569627 ZNF746 zinc finger protein 746 2 2
MIRT570530 RPH3A rabphilin 3A 2 2
MIRT570939 CPE carboxypeptidase E 2 2
MIRT574774 FGF2 fibroblast growth factor 2 2 2
MIRT620120 LACC1 laccase domain containing 1 2 2
MIRT624338 CISD1 CDGSH iron sulfur domain 1 2 2
MIRT625434 RMDN1 regulator of microtubule dynamics 1 2 2
MIRT640528 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT646916 TRIM14 tripartite motif containing 14 2 2
MIRT656298 METTL1 methyltransferase like 1 2 2
MIRT660192 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT661360 DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 2 2
MIRT667769 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT683187 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT685843 ANGEL1 angel homolog 1 2 2
MIRT688553 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT689424 CYB561 cytochrome b561 2 2
MIRT698505 TGFBR1 transforming growth factor beta receptor 1 2 2
MIRT701232 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT702506 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT706488 SEPT6 septin 6 2 2
MIRT713774 ZNF460 zinc finger protein 460 2 2
MIRT716991 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT722644 MPEG1 macrophage expressed 1 2 2
MIRT725254 PARVB parvin beta 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6733 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-6733 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6733-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6733-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6733-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6733-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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