miRTarBase - #MIRT221382


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pre-miRNA Information
pre-miRNA hsa-mir-3152   
Genomic Coordinates chr9: 18573306 - 18573379
Description Homo sapiens miR-3152 stem-loop
Comment Berezikov et al. proposed this sequence as a miRNA candidate based on the RAKE method .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3152-3p
Sequence 45| UGUGUUAGAAUAGGGGCAAUAA |66
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8332435 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1056852374 2 dbSNP
rs894329932 11 dbSNP
rs1429410622 12 dbSNP
rs13299349 13 dbSNP
rs539052066 14 dbSNP
rs1028341616 15 dbSNP
rs969346701 16 dbSNP
rs1176815888 19 dbSNP
rs1474970048 19 dbSNP
rs1240079601 21 dbSNP
Putative Targets

Gene Information
Gene Symbol DNAJB6   
Synonyms DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MRJ, MSJ-1
Description DnaJ heat shock protein family (Hsp40) member B6
Transcript NM_058246   
Other Transcripts NM_005494   
Expression
Putative miRNA Targets on DNAJB6
3'UTR of DNAJB6
(miRNA target sites are highlighted)		 
>DNAJB6|NM_058246|3'UTR
   1 ACCGGACTTGAGGCACGCGGTGCACCCCCAGACGCTGGCGCTCCACCGTGCTCGGCATGCGGTCGTGCACACGCGCTAGG
  81 TAGCAGCGTCGGTCAGGACTGTCTCGAGGCCACACTCGCTCGGCAGGATTATGCGATCACGGATCAGTCAGAGCAGGGTC
 161 AGGAGACGGGGCTGACGGCACGGGTGGCGGGGACAGACGTTTGGGACTTGGCCGCGACTCTCTGCTTCTCTCCAGCTCTC
 241 AATCTGCTGCATTTTCCTCTAGTGCTTCCGGATCCTCTTCATTCTTTTCGGCTACTCAACCACTCCGCATGCTGCTGGAA
 321 TATTTCTGGCTTTAGAAGTACAGGAGGGCGCAGATGGCTAACTGAGTAACATTCATGAAATGAGGCTTTCTGTGGCGGCG
 401 TAGTGTTTGGAATTAGAAGGTAATTCAGTAGAGTGTAACTTAGAGAATATTGCAAGTGACACATTGAATCCTGCCCGTCA
 481 GGGCACCTTTTCCTCAGAGCAATCCGGCCACACGAATAGAAGGCTGTCGTGAATCACATCAGATGTAAAATCATTCCTTC
 561 TGTTTACTCTTTTAATTTTCATCCTTTGCAGGTAGTGCAAATTCAACTTCAAATATGGTGTAGGTTTTGCTAGATTCCAT
 641 ATTTTTTTCTTGGATTTTTGCTAATTATTTTTAGCAAAAAATTTTTGCTCAGTGGCACTCTCCCTAGTGTCCATGGGTTA
 721 GGGCCATGCTGGGGAAAACGGGCCGGTATTTACACACGCGCAAAACACCCAGAGACGGCACAAGGAGGTTGAACTCATGT
 801 TTCAGTTCGCGAACATTGACTCCTTACGAAAGTCACTTCATTCTAACTAGATGCGCCCACTTCCGGTCATTATTTCGTTT
 881 GCATGATGTATTGCTTCTTCACGTTTTGTTTTTATTGAGCACGGAGTAGAATTCCAGGGCTGCCTTGACTTCTTCCCTGC
 961 ATGCTCCCTCCCAGTGACTTTCCTTCCCTTTCACATGAGGATCTGCCGTTCATGTTGCTTTCTCCTTTGTCCTCTTGGAC
1041 TTGAGGGCATTGTGAAAAGCTTTGCTGTGATTTAAAAATGCCAGCAATTTTAATCTAGCAGTGTTGAAGCTGGGAATTTT
1121 TTGGCGCAATCCATGTAGCAGTGACCCAGGCTTGGGAGCCAGAAACAAGTGTGACCTGGGATTTTATTTAACACAACTGT
1201 TGCCAAAGAGTTGGCTTTGTTTATTTGGTTTTGGCGGGGAGAGGAGTGGTATTTGATGCTTTCTGTGGACAATGTAACCC
1281 TAAACACATCATGTATTTTAAATGCCACCTACATAAATAAAACATAAGCATATTGAATACAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aauaaCGGGGAUAAGAUUGUGu 5'
               | :::|| |:|||||| 
Target 5' cctggGATTTTA-TTTAACACa 3'
 1175 - 1195 136.00 -9.50
2 
miRNA  3' aauaaCGGGGA--UAAGAUUGugu 5'
               |:| ||  ||||||||   
Target 5' cgaaaGTCACTTCATTCTAACtag 3'
 827 - 850 123.00 -10.22
3 
miRNA  3' aaUAACGG------GGAUAAGAUUGUgu 5'
            | ||||      ::|| ||||:||  
Target 5' aaAATGCCAGCAATTTTAATCTAGCAgt 3'
 1075 - 1102 122.00 -9.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
282119 4 ClinVar
385378 18 ClinVar
359457 65 ClinVar
359458 73 ClinVar
909392 73 ClinVar
359459 89 ClinVar
909393 99 ClinVar
909394 106 ClinVar
359460 119 ClinVar
910345 216 ClinVar
910346 244 ClinVar
359461 290 ClinVar
910347 300 ClinVar
359462 307 ClinVar
910348 308 ClinVar
359463 383 ClinVar
359464 490 ClinVar
911556 503 ClinVar
911557 514 ClinVar
359465 515 ClinVar
359466 529 ClinVar
359467 587 ClinVar
359468 605 ClinVar
359469 607 ClinVar
359470 611 ClinVar
908605 637 ClinVar
359471 640 ClinVar
908606 665 ClinVar
359472 700 ClinVar
359473 727 ClinVar
359474 760 ClinVar
359475 777 ClinVar
359476 782 ClinVar
359477 788 ClinVar
359478 903 ClinVar
909463 924 ClinVar
359479 935 ClinVar
909464 966 ClinVar
359480 967 ClinVar
910405 1009 ClinVar
359481 1237 ClinVar
COSN23016961 17 COSMIC
COSN31592639 18 COSMIC
COSN30543059 40 COSMIC
COSN8516114 41 COSMIC
COSN29468675 49 COSMIC
COSN31601809 49 COSMIC
COSN24311196 65 COSMIC
COSN31611334 75 COSMIC
COSN30533199 89 COSMIC
COSN7657693 141 COSMIC
COSN20621045 428 COSMIC
COSN9979658 905 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1443631898 1 dbSNP
rs140445215 4 dbSNP
rs538057079 5 dbSNP
rs748781499 6 dbSNP
rs1331022826 12 dbSNP
rs1465917108 13 dbSNP
rs1373925370 16 dbSNP
rs754496495 17 dbSNP
rs369235805 18 dbSNP
rs577875381 19 dbSNP
rs771151320 20 dbSNP
rs372172001 23 dbSNP
rs192037366 24 dbSNP
rs1291963093 26 dbSNP
rs746303138 27 dbSNP
rs1003356872 28 dbSNP
rs377063562 29 dbSNP
rs1438292311 32 dbSNP
rs369741728 34 dbSNP
rs763062645 35 dbSNP
rs768816202 37 dbSNP
rs774391788 38 dbSNP
rs542342637 40 dbSNP
rs767669570 41 dbSNP
rs369221072 44 dbSNP
rs1390163861 45 dbSNP
rs561059767 47 dbSNP
rs142165399 48 dbSNP
rs754405567 49 dbSNP
rs1446428433 52 dbSNP
rs377683714 54 dbSNP
rs1323646864 55 dbSNP
rs551156852 59 dbSNP
rs1011792317 61 dbSNP
rs965557122 62 dbSNP
rs562936080 65 dbSNP
rs1381653449 66 dbSNP
rs954402824 68 dbSNP
rs1251463854 69 dbSNP
rs116630040 73 dbSNP
rs150779247 74 dbSNP
rs1213977664 75 dbSNP
rs776254454 76 dbSNP
rs1397239496 83 dbSNP
rs1030976259 88 dbSNP
rs139193261 89 dbSNP
rs541259018 91 dbSNP
rs1388267012 93 dbSNP
rs972498518 95 dbSNP
rs879110420 96 dbSNP
rs1287879184 102 dbSNP
rs534203597 106 dbSNP
rs1361823130 116 dbSNP
rs764933589 118 dbSNP
rs886062130 119 dbSNP
rs773534306 122 dbSNP
rs549360686 123 dbSNP
rs1441955904 124 dbSNP
rs1434096902 131 dbSNP
rs1305946005 135 dbSNP
rs1372879138 140 dbSNP
rs567762107 141 dbSNP
rs1231896135 142 dbSNP
rs949220233 147 dbSNP
rs1345870908 148 dbSNP
rs753180096 159 dbSNP
rs1046335065 165 dbSNP
rs926520826 168 dbSNP
rs756598628 177 dbSNP
rs537908243 178 dbSNP
rs946600853 179 dbSNP
rs893103166 181 dbSNP
rs764284901 182 dbSNP
rs1042165524 183 dbSNP
rs1413595238 186 dbSNP
rs556372247 189 dbSNP
rs544983219 190 dbSNP
rs146779424 199 dbSNP
rs998313618 200 dbSNP
rs1188174807 202 dbSNP
rs1168790287 208 dbSNP
rs1028887540 214 dbSNP
rs1364817936 215 dbSNP
rs953620507 216 dbSNP
rs759467623 217 dbSNP
rs1015881680 218 dbSNP
rs1471452978 229 dbSNP
rs1484705078 231 dbSNP
rs140516420 233 dbSNP
rs1017166941 236 dbSNP
rs1483546962 237 dbSNP
rs1250752558 241 dbSNP
rs571981993 243 dbSNP
rs971860158 244 dbSNP
rs1278410510 245 dbSNP
rs542232099 252 dbSNP
rs1026466800 257 dbSNP
rs1392559728 260 dbSNP
rs972382657 264 dbSNP
rs866911588 270 dbSNP
rs554220388 271 dbSNP
rs982347227 278 dbSNP
rs886062131 290 dbSNP
rs939042113 300 dbSNP
rs576133569 307 dbSNP
rs1286436589 308 dbSNP
rs989362447 310 dbSNP
rs946554053 314 dbSNP
rs1044074680 318 dbSNP
rs1249697801 327 dbSNP
rs1176751078 329 dbSNP
rs1458885614 336 dbSNP
rs144227992 342 dbSNP
rs765359297 344 dbSNP
rs1053011975 347 dbSNP
rs183388200 354 dbSNP
rs139354905 358 dbSNP
rs377402170 358 dbSNP
rs1334699726 367 dbSNP
rs35743737 383 dbSNP
rs1449693151 385 dbSNP
rs1378025930 386 dbSNP
rs1325667406 393 dbSNP
rs1460263816 396 dbSNP
rs933536433 397 dbSNP
rs78084094 398 dbSNP
rs1475538088 399 dbSNP
rs1017637749 400 dbSNP
rs560780381 401 dbSNP
rs548095526 405 dbSNP
rs527946209 414 dbSNP
rs1192760676 420 dbSNP
rs562917032 423 dbSNP
rs1210087877 425 dbSNP
rs993559167 428 dbSNP
rs1168757023 447 dbSNP
rs779337072 451 dbSNP
rs960456796 453 dbSNP
rs991001300 454 dbSNP
rs373966747 455 dbSNP
rs968320956 457 dbSNP
rs981844807 461 dbSNP
rs530534417 463 dbSNP
rs146575525 471 dbSNP
rs1294617583 477 dbSNP
rs764452717 478 dbSNP
rs959163955 479 dbSNP
rs1420447686 484 dbSNP
rs187704048 490 dbSNP
rs549993404 493 dbSNP
rs1172977737 501 dbSNP
rs1476904926 502 dbSNP
rs1379188183 503 dbSNP
rs1199050762 504 dbSNP
rs757128702 506 dbSNP
rs1053063775 507 dbSNP
rs1218163075 509 dbSNP
rs201347914 511 dbSNP
rs780921412 512 dbSNP
rs538467964 514 dbSNP
rs17837760 515 dbSNP
rs1347524341 522 dbSNP
rs886062132 529 dbSNP
rs79489534 535 dbSNP
rs977815944 543 dbSNP
rs1338696503 556 dbSNP
rs747903215 558 dbSNP
rs1400656082 567 dbSNP
rs889866817 569 dbSNP
rs1333385435 572 dbSNP
rs1251655170 583 dbSNP
rs1426937135 584 dbSNP
rs886062133 587 dbSNP
rs750365399 589 dbSNP
rs1475001643 591 dbSNP
rs1195464401 595 dbSNP
rs1006139938 600 dbSNP
rs1486298352 602 dbSNP
rs924757324 603 dbSNP
rs1208554931 604 dbSNP
rs78938721 605 dbSNP
rs570569711 607 dbSNP
rs1423373491 609 dbSNP
rs886062134 611 dbSNP
rs1375070122 613 dbSNP
rs1280309084 617 dbSNP
rs1035253706 622 dbSNP
rs1354827286 631 dbSNP
rs960401256 633 dbSNP
rs1011907637 634 dbSNP
rs1334799369 635 dbSNP
rs756063127 637 dbSNP
rs554589200 639 dbSNP
rs76450641 640 dbSNP
rs1412367130 642 dbSNP
rs993217781 643 dbSNP
rs1179592560 647 dbSNP
rs1473531721 648 dbSNP
rs1369818007 650 dbSNP
rs1026403328 651 dbSNP
rs1456681068 652 dbSNP
rs1435296186 654 dbSNP
rs1199445520 664 dbSNP
rs779593683 665 dbSNP
rs906165286 668 dbSNP
rs1288072761 680 dbSNP
rs1003716688 681 dbSNP
rs1314697734 682 dbSNP
rs1380047562 682 dbSNP
rs1376315151 685 dbSNP
rs543530610 691 dbSNP
rs4716719 700 dbSNP
rs192271769 706 dbSNP
rs1348933104 707 dbSNP
rs975993463 708 dbSNP
rs1406577870 713 dbSNP
rs923187056 714 dbSNP
rs1158528532 724 dbSNP
rs7787595 727 dbSNP
rs1022253448 729 dbSNP
rs1240638382 730 dbSNP
rs560623928 740 dbSNP
rs1488382626 741 dbSNP
rs1245183106 744 dbSNP
rs911297909 746 dbSNP
rs1274411207 750 dbSNP
rs977993107 756 dbSNP
rs924612076 758 dbSNP
rs778560594 759 dbSNP
rs1059752 760 dbSNP
rs987542418 762 dbSNP
rs542944956 764 dbSNP
rs1056768850 767 dbSNP
rs1438208921 769 dbSNP
rs550265054 772 dbSNP
rs115297289 777 dbSNP
rs1297028919 778 dbSNP
rs886062135 782 dbSNP
rs1382670162 783 dbSNP
rs1012329108 784 dbSNP
rs920735315 787 dbSNP
rs184330731 788 dbSNP
rs1047948107 790 dbSNP
rs550121755 795 dbSNP
rs1389283362 798 dbSNP
rs1454586013 804 dbSNP
rs1003192609 809 dbSNP
rs188002105 810 dbSNP
rs1175422318 811 dbSNP
rs1030692260 812 dbSNP
rs1298925572 815 dbSNP
rs532491697 816 dbSNP
rs894888675 828 dbSNP
rs1010781950 829 dbSNP
rs1288964386 833 dbSNP
rs953280186 839 dbSNP
rs1022138872 844 dbSNP
rs1361927021 847 dbSNP
rs1386631208 853 dbSNP
rs1432405161 855 dbSNP
rs966534358 856 dbSNP
rs1178667990 860 dbSNP
rs532429399 865 dbSNP
rs999860686 866 dbSNP
rs868775317 877 dbSNP
rs974194050 878 dbSNP
rs918667243 882 dbSNP
rs1372169442 884 dbSNP
rs1029563605 885 dbSNP
rs1237052093 888 dbSNP
rs1211937935 901 dbSNP
rs547235102 903 dbSNP
rs1056607142 904 dbSNP
rs375510987 905 dbSNP
rs192836867 923 dbSNP
rs149171640 924 dbSNP
rs886062136 935 dbSNP
rs1395000685 943 dbSNP
rs1208318571 944 dbSNP
rs973425108 948 dbSNP
rs1305149702 950 dbSNP
rs1466851469 953 dbSNP
rs1468746294 956 dbSNP
rs770410693 963 dbSNP
rs143332396 967 dbSNP
rs997305280 969 dbSNP
rs1048472600 972 dbSNP
rs1030096912 973 dbSNP
rs953429853 976 dbSNP
rs76436765 980 dbSNP
rs1461574109 994 dbSNP
rs569902814 998 dbSNP
rs1196308237 1008 dbSNP
rs986094779 1008 dbSNP
rs928224062 1009 dbSNP
rs939032251 1013 dbSNP
rs974035949 1016 dbSNP
rs552643388 1019 dbSNP
rs894771165 1027 dbSNP
rs1338239242 1039 dbSNP
rs1315379970 1041 dbSNP
rs1010667179 1044 dbSNP
rs1043465415 1048 dbSNP
rs1455243200 1050 dbSNP
rs1376538983 1065 dbSNP
rs1271364722 1066 dbSNP
rs1329745200 1075 dbSNP
rs918678645 1085 dbSNP
rs1401263603 1111 dbSNP
rs902369964 1117 dbSNP
rs1456415649 1125 dbSNP
rs148354776 1126 dbSNP
rs1166751058 1127 dbSNP
rs1445183944 1146 dbSNP
rs1394763646 1148 dbSNP
rs774716509 1150 dbSNP
rs369876849 1153 dbSNP
rs891044867 1155 dbSNP
rs1443485973 1166 dbSNP
rs948204012 1170 dbSNP
rs1292173987 1171 dbSNP
rs1208891459 1176 dbSNP
rs1353594819 1178 dbSNP
rs1266702620 1179 dbSNP
rs762188320 1181 dbSNP
rs1353599382 1186 dbSNP
rs1045361859 1194 dbSNP
rs1242741749 1199 dbSNP
rs1336750006 1222 dbSNP
rs1323098180 1228 dbSNP
rs1309850923 1231 dbSNP
rs1327149688 1233 dbSNP
rs1392902276 1234 dbSNP
rs904093037 1236 dbSNP
rs886062137 1237 dbSNP
rs1419252747 1239 dbSNP
rs1007885376 1240 dbSNP
rs1156825652 1251 dbSNP
rs1441262165 1252 dbSNP
rs558484696 1264 dbSNP
rs1052010497 1269 dbSNP
rs1269092314 1271 dbSNP
rs1017567769 1273 dbSNP
rs577013441 1274 dbSNP
rs140589399 1275 dbSNP
rs1284442869 1276 dbSNP
rs1223445625 1278 dbSNP
rs1219475927 1280 dbSNP
rs1351771073 1282 dbSNP
rs1059820 1308 dbSNP
rs1274647661 1318 dbSNP
rs1244733141 1324 dbSNP
rs997192388 1325 dbSNP
rs1284207483 1326 dbSNP
rs369519622 1328 dbSNP
rs1399449428 1330 dbSNP
rs112650801 1331 dbSNP
rs759192072 1337 dbSNP
rs964654492 1340 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aauaacggggAUAAGAUUGUGu 5'
                    ||  ||||||| 
Target 5' ----------UACACUAACACc 3'
 		1 - 12
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 10049.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aauaacggggAUAAGAUUGUGu 5'
                    ||  ||||||| 
Target 5' ----------UACACUAACACc 3'
 		1 - 12
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 10049.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_005494 | 3UTR | AUAGGACCAUUUUUUUUUUGUCUUUAAAAUUGUUGUAAAUCUCUGUAUGCACUUUGCUUUUUUAUUAAACGUACUCCAAGGUGAGUCUUGACUCUUUAGUGUAGGACAAGAUUGUACACUAACACCAGCAUGGACCUGCUUUUCAUUGUGUCUGAAAUGUGAGCCACGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_005494 | 3UTR | AUUGUUGUAAAUCUCUGUAUGCACUUUGCUUUUUUAUUAAACGUACUCCAAGGUGAGUCUUGACUCUUUAGUGUAGGACAAGAUUGUACACUAACACCAGCAUGGACCUGCUUUUCAUUGUGUCUGAAAUGUGAGCCACGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_005494 | 3UTR | AAAUUGUUGUAAAUCUCUGUAUGCACUUUGCUUUUUUAUUAAACGUACUCCAAGGUGAGUCUUGACUCUUUAGUGUAGGACAAGAUUGUACACUAACACCAGCAUGGACCUGCUUUUCAUUGUGUCUGAAAUGUGAGCCACGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_005494 | 3UTR | AAAAUUGUUGUAAAUCUCUGUAUGCACUUUGCUUUUUUAUUAAACGUACUCCAAGGUGAGUCUUGACUCUUUAGUGUAGGACAAGAUUGUACACUAACACCAGCAUGGACCUGCUUUUCAUUGUGUCUGAAAUGUGAGCCACGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_005494 | 3UTR | AAAAUUGUUGUAAAUCUCUGUAUGCACUUUGCUUUUUUAUUAAACGUACUCCAAGGUGAGUCUUGACUCUUUAGUGUAGGACAAGAUUGUACACUAACACCAGCAUGGACCUGCUUUUCAUUGUGUCUGAAAUGUGAGCCACGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_005494 | 3UTR | AUGCACUUUGCUUUUUUAUUAAACGUACUCCAAGGUGAGUCUUGACUCUUUAGUGUAGGACAAGAUUGUACACUAACACCAGCAUGGACCUGCUUUUCAUUGUGUCUGAAAUGUGAGCCACGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000429029.2 | 3UTR | UACACUAACACCAGCAUGGACCUGCUUUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000429029.2 | 3UTR | UACACUAACACCAGCAUGGACCUGCUUUUCAUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000429029.2 | 3UTR | ACACUAACACCAGCAUGGACCUGCUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000429029.2 | 3UTR | UACACUAACACCAGCAUGGACCUGCUUUUCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
60 hsa-miR-3152-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT068760 RB1 RB transcriptional corepressor 1 2 2
MIRT142268 DCTN5 dynactin subunit 5 2 8
MIRT179443 TBRG1 transforming growth factor beta regulator 1 2 2
MIRT221382 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 6
MIRT332510 CD81 CD81 molecule 2 2
MIRT442419 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT445519 PLXDC2 plexin domain containing 2 2 2
MIRT464185 VMA21 VMA21, vacuolar ATPase assembly factor 2 2
MIRT467933 SLC16A6 solute carrier family 16 member 6 2 2
MIRT468378 SETD5 SET domain containing 5 2 2
MIRT468486 SESN3 sestrin 3 2 2
MIRT468928 RPS24 ribosomal protein S24 2 2
MIRT478171 DENND5B DENN domain containing 5B 2 2
MIRT490447 GLUD1 glutamate dehydrogenase 1 2 2
MIRT494675 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT502287 GNG5 G protein subunit gamma 5 2 6
MIRT506078 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 6
MIRT508008 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT508760 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT509091 SYNPO2L synaptopodin 2 like 2 4
MIRT511968 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT515210 CRCP CGRP receptor component 2 2
MIRT516377 TRAF3IP2 TRAF3 interacting protein 2 2 4
MIRT517047 ZNF678 zinc finger protein 678 2 2
MIRT521125 SHROOM4 shroom family member 4 2 2
MIRT521277 RTF1 RTF1 homolog, Paf1/RNA polymerase II complex component 2 2
MIRT522772 LAMP2 lysosomal associated membrane protein 2 2 6
MIRT524419 CNKSR3 CNKSR family member 3 2 2
MIRT529398 ICK intestinal cell kinase 2 2
MIRT529965 PHF7 PHD finger protein 7 2 2
MIRT530189 TIGD2 tigger transposable element derived 2 2 2
MIRT533716 TMEM30A transmembrane protein 30A 2 2
MIRT543170 FICD FIC domain containing 2 2
MIRT548496 E2F8 E2F transcription factor 8 2 2
MIRT555020 RAB23 RAB23, member RAS oncogene family 2 2
MIRT560728 ZNF529 zinc finger protein 529 2 10
MIRT564890 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT567327 HMGB1 high mobility group box 1 2 2
MIRT568035 CLIP4 CAP-Gly domain containing linker protein family member 4 2 2
MIRT574763 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT620811 SLC26A2 solute carrier family 26 member 2 2 2
MIRT622456 RNF19B ring finger protein 19B 2 2
MIRT636240 SIM1 single-minded family bHLH transcription factor 1 2 2
MIRT643231 MUC15 mucin 15, cell surface associated 2 2
MIRT646319 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT646674 CCDC69 coiled-coil domain containing 69 2 2
MIRT650043 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT652533 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT663022 CD40LG CD40 ligand 2 2
MIRT667465 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT668620 EEA1 early endosome antigen 1 2 2
MIRT675678 SLC35F5 solute carrier family 35 member F5 2 2
MIRT681814 N4BP2L2 NEDD4 binding protein 2 like 2 2 2
MIRT682674 CPM carboxypeptidase M 2 2
MIRT701447 NFIC nuclear factor I C 2 2
MIRT706222 C20orf144 chromosome 20 open reading frame 144 2 2
MIRT707510 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT710466 ASTN2 astrotactin 2 2 2
MIRT712957 SGCD sarcoglycan delta 2 2
MIRT723030 MYLIP myosin regulatory light chain interacting protein 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3152-3p 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3152-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3152-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-3152-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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