miRTarBase - #MIRT223632


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pre-miRNA Information
pre-miRNA hsa-mir-16-2   
Genomic Coordinates chr3: 160404745 - 160404825
Description Homo sapiens miR-16-2 stem-loop
Comment This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MIR:MI0000070). The sequence was previously named mir-16-3 here and in references .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-16-2-3p
Sequence 53| CCAAUAUUACUGUGCUGCUUUA |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30477465 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs746992239 2 dbSNP
rs775368833 4 dbSNP
rs373202341 10 dbSNP
rs768780684 13 dbSNP
rs1341798864 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ATP6V1C1   
Synonyms ATP6C, ATP6D, VATC, Vma5
Description ATPase H+ transporting V1 subunit C1
Transcript NM_001695   
Expression
Putative miRNA Targets on ATP6V1C1
3'UTR of ATP6V1C1
(miRNA target sites are highlighted)		 
>ATP6V1C1|NM_001695|3'UTR
   1 AAATGGGCTCCTCCCCCGACAATCCTGTCCTTGTGTTTGTGTGTGCTAACAGAAATAAGTTGCAGTATGGTCGTACTTTT
  81 AACTCTAGTATCCTTTGCTTGCTTCTTACGCCCTTTCCTAGGTGAATTCTCCCACAGTGGTCTGTATCTCAACATTTTCT
 161 TTTTAAAGGAAAAAATATATATATATAGTTTCTTTTTATTGATCAGGTCTGTAAATGTGTACTAAAAAAATCAGAGTTTA
 241 TTTATAAACAAAATAGTTTATTTAAAGAGAAGGTCTCTTCCTTATTGATATCATGGTATGCATTAATTCCATTTGTTACT
 321 ATTGTGCACAAAAGCCCTGTTCACAGGGGAATGGTGTAAACATTTATACTGTTTTGTTCACTGTATTTAGTAGACATAAC
 401 TGTTGAATAGTTACTGAATCATGATGTAAAGAATATGTGACCATCTTCAGGTATGGGATTTCTGAACGTTTCAAATTTCA
 481 ATCAATGAGCACTGTCAACACCCACAGGAGAGAATAAAATTACCTGTGCAAAGGTGTATTGTGGTGTGTGTAACTTAAGA
 561 TTACAGTTCTGTTTGAGAGTTAAATGATGTCATAGCTCACTTGCTATGCTGCTTCCAGGATTTTGTTATATGCTGAGGTG
 641 TAACCATTTGTGTTGTCTGACTTTCGTATGATTTAATTGAGCCAAATTTGGGTCAGAACACAAATTTGAAGATGACTTTT
 721 CAGTATATGATGGGTATTTACATTTGAACACTAGAATTTTAGGTCTCTCAAATAATTAAGAATAGAGCCAGTTTTGAATA
 801 AAGTCTAGCAGAACTATGCAGCTTTAGTCATTTGTTTTGTCTAAGTCTGTATTTTATGTGTTGTCTTCTTAAGATCTATA
 881 ATTTTGGCATTTATGTCATTTGTGACATAGTCTGAAAATAGAGACATTGTTGGCCTTTAAAATCTCAGAAATGAATGACT
 961 TAATTTAGTGTCCTGAAAGAGCTTTTAAAAGAGGATTTTGTGGCAATGTTTCTCTTACTACGTACTCACAGGTTTGCAAA
1041 TGGGAAAAAAGTTTACATTTCAGTTTAGGGGCATATCTAAGCTATGCTATTCCCTTTAGAAAATTAGCCTCCAAAATCTT
1121 TTGTTTCAAAATATTATATTATTTCATAAATAATTTCAAGCAAATACAGACATCCACAATGTAGAACATGAGAGACCCCC
1201 TCCCTCAATTTCCACCTCCCAAGGGAAGTTTATGTATTTTTCTAGGCCCTTTTCTATGTCTTTACATCTCTGTCTCACAC
1281 ACACACACGTATACACACACACAGTTTATTTTTAATAAAATAGGATTATACCACACACATCCTGTCACTTGCTTTTTTGC
1361 TTAAGAGTATATCTAAGAGAATCCTTTGTGTCAGTGAAGCTGGAGCTACCTCATTCTTTTAACTGGCTGCGTGGCGTTCC
1441 ATTGAGTGTCTGTCATCATGTGTTTAGCCGAGTGGATGGATAGTCTGCTTGTTTTTAGTTTTTGCTCTTAACAAACACTG
1521 CTGCAGTCAGCATCCTTGCACAGATTTCTTTGTATACTTGTATTAGTATTTCTGTAAGATCTGAGAAGTGGAATTTGTAG
1601 GGTCATAGGTTATGTACACTTAAGTTTTTGACACTCACTGCCAAGTCATCTGTCAGAATTCTAAACTAAAGACATGTTTG
1681 GAGTGTGGATTTATCTTCAGTTTTTCTTTGGACAAGAGGAAGCTGTGAAAGATTTTGCTATCAGAAAATTTTGGTTCTTT
1761 GTCTTTTGCACATGTTCTTTGAGTCTTAGTATCTGTAACGTGGCGCTACTCTCTCTATCATGGGGGGGCATGTTTTGACA
1841 TTAAATTGACTTTTAAGAAAAACATGTCACTAACCTGAAGCTCAGCCACACAGTGACTTTTAAGGTTTTATTTAGACTTT
1921 ACTGTTGTTCTCATGAGAGTAGGTACAGACTGCATAAGGTTTAGAATCCCAGCATATGTCTGAAACGACGGGACTTTCAC
2001 TGTGATTTCCACCAGAGAAATTATAGCAGAGTGGCTGAGCATGTGCTCTGAGGCCAGGCCCCAGCTCTGCTGCTGACGAG
2081 CTGTGTGGTCCTGGGCAGAGTGGTCTCCGAGTTCCAGTCCCTCCTCTGTAAAATGGGCATGATTAGAGTGCCCACCGCAT
2161 TAGGGATGTTGGGGTGAGTCAGTGTGACCCCACGTGCACAGAAAGTGCTGCGAGTGGTGCATGGTGAGAGGTTGATGCAG
2241 GTACTTAGCCCTTGGGGAACACAGGTAGTTCCTTTTCACTGTGTTTAATTTGGGAAAATCCAGATCCACATCATTGTAGA
2321 GTCTGAGGGTTAGAAGGAAGTCATTGTGTCTAACATAACAACAGAGCAGTTTGTGTCACTGAGCTCCAGTCTGTGCTGGA
2401 TTATTGATATTGTTGGTGGCGGTCACCATTCCTGGAAAGGGACTGTCCCAAGCCACTTACCTTCCCGAGGAGTCTGCTGG
2481 TTCTCCTTGAGGATAGTGCTTAGATAACAGACTCATTAAACATTTACTGAGTGTCTGTCAGGGATCATTCACATCCACAT
2561 CATCCTCCCGGCCCCTCCCCGTGTTGTTCATGGAGGGAGTACTGGCGGTCCCCATTTTCATGTATGGAGACTTCAGGTGA
2641 AAGAAGTTAAGTGAATTCTTTGTTGAGTCACAAATCTTGAGCCAGTCAGAATTTGAACCTAAGATTTTTGACTGCTGGTT
2721 GTCACACTTCCCGCCCCACACTCAACTGTTGTGTGAATGAGCCAGACACATTGCTTAACCTGAGTCCGAGATGGACAATG
2801 GTATAGGAAAGATATTCGGTATGGAGAATCAGATGTTAACTTGTGTTGCTATTTTTGTTTTGTTTTGTTTTGTTTTGTTT
2881 TTGAGACAAGGTCTTGCTCTGTCACCCAGGCTAGAGTGCAGTGGCATGATCAGGGCTTACTGCAGCCTCACCCTCGATTT
2961 CCTGGGCTCAAGCAATCCTCCCACCTCAGCCCCCAAGTAGCTGGGCCTACAGGTGCGTGCTACCACGCCTGGCCAATTTT
3041 TTAAATTTTAGCACAGATGAGGTCTCACTATGTTGCCCGGGCTGGTCTCGAACTCCTGAGCTCAAGGGATCCTCCCGCCT
3121 CAGCCTCCCAAAGTGCTGGTGTTACAGGCATAAGCCACCACGCCTGGCCTGTGTTGCTATTATATTTGGCAGGAACCCAG
3201 AGTCCAGAACATTTCATCTATGATGGGTTAGATAATGTGTCTAGTTGTTTGCATGCCAATTTCAGTAGCCTCAGTTATTC
3281 AACCTAGGAGATTTTTCTACCTCTTTACTACCCTGCTGAAGTTGCTCTTCAGCAGAAAATCTTTGTGGAACACATTCCAC
3361 ACTTTGAAATCTTCGTGGAACAAAAGATATTTGTGGAACCAATCTTTGTGGAACATATTCCAGCTTTTTGAATGAGTGCA
3441 TATCCAGTAGTACCTTTAAAGTAACACTTTGTACATAACAAATACTCAGCAAATGTGAAACTTTATTTGCTCTTACTTCA
3521 AAATTAGTCCAAAATGTTGGAAATAAAATATAAGACATTGATCTAGATATGAGGTTTTTCTCCTTCATTCTCAGCTGTCG
3601 AAGAAATCAAAGTAGCATATGCACAAGGTTAAAAACCACATATACAAATACTATAGAACAGCTTATAATGAAAACCTTGC
3681 CTGCCTTTATAAAAAATGTGATTATCTTCTTCTGTTAATGTCAATAAAAGATGGTTTGTCCTAGAAGGTCTATAAATGGT
3761 ATTATGTTCTGGAGGAAACCTAGCAAAAACTTTGCTAGTTTAGTACTTGTCTCTAAATTGATGTTCACCCATTTCAATAT
3841 TGCACTTATTAATGGTCTTTATTTTTCTAGCATAGATAACAATTGATTCTTTAGATTCATATATGGAGGTAATTCTTGCT
3921 TTCTAAAGAAAGGAATATGGCACATTGGAACCATTTTATTCACCAGTGGATTTACCCTTAGAGTATTTTTAGATCTGAGC
4001 TGATGACTTGTGAGAGAAAAAGGGAACAGAGTAAAGCCATGGAAGCCATGAACAGTAAGAGACTGCCGCCTGGCATGGTT
4081 TCTTCTTCTGCAGAAGATGAAACTGAGGAGAAACAAGACAACATCCTTCATACCAGGAATGGTCAAGATAATGCAAGAAG
4161 AAAAAAGCTTTCAAACAAATCAGAAGGCAGTCAACAAACAGAAAGGGGGACATTCCTTCCCTGGCAGTTACTCAAAACTG
4241 AAATTGCTTATTGTGTACACCGGGGCTTGTACTTGGGGAATTTAATAAAAATGCTCATTACCAAGCTCCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auUUCGUCGUGUCAUUAUAACc 5'
            || :||: ||  |||:||| 
Target 5' aaAATTAGTCCA-AAATGTTGg 3'
 3520 - 3540 139.00 -10.10
2 
miRNA  3' auuuCGUCGU-GUCAUUAUAACc 5'
              || | | :| |:|||||| 
Target 5' ctgtGCTGGATTATTGATATTGt 3'
 2391 - 2413 138.00 -6.00
3 
miRNA  3' auuucGUCGU-GUCAUUAUAACc 5'
               | ||| :|| :||:||| 
Target 5' gcccaCCGCATTAGGGATGTTGg 3'
 2150 - 2172 125.00 -12.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30503997 6 COSMIC
COSN26967317 9 COSMIC
COSN17181678 11 COSMIC
COSN30456549 30 COSMIC
COSN1356825 41 COSMIC
COSN31601807 53 COSMIC
COSN28779339 56 COSMIC
COSN31545101 74 COSMIC
COSN30532158 102 COSMIC
COSN30532171 103 COSMIC
COSN20076238 141 COSMIC
COSN20076391 175 COSMIC
COSN20384493 252 COSMIC
COSN17181682 480 COSMIC
COSN4922685 497 COSMIC
COSN20961935 697 COSMIC
COSN30059327 825 COSMIC
COSN32057824 1022 COSMIC
COSN15660665 1128 COSMIC
COSN21352089 1489 COSMIC
COSN17667130 1651 COSMIC
COSN5230211 1856 COSMIC
COSN4874276 1882 COSMIC
COSN15742268 1958 COSMIC
COSN21736799 2304 COSMIC
COSN17038121 2490 COSMIC
COSN20748927 2816 COSMIC
COSN21736106 2833 COSMIC
COSN20744347 3062 COSMIC
COSN4922686 3220 COSMIC
COSN21668064 3491 COSMIC
COSN15753110 3558 COSMIC
COSN21461520 3725 COSMIC
COSN9776088 3995 COSMIC
COSN32058442 4225 COSMIC
rs17403069 x rs16870 2812 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs775399738 3 dbSNP
rs1043816712 4 dbSNP
rs796945951 6 dbSNP
rs374231753 11 dbSNP
rs886243187 12 dbSNP
rs1303645855 13 dbSNP
rs368761745 14 dbSNP
rs559796889 18 dbSNP
rs764799093 19 dbSNP
rs1372944900 20 dbSNP
rs755489178 23 dbSNP
rs1033824127 25 dbSNP
rs767965081 28 dbSNP
rs371003118 30 dbSNP
rs533505965 31 dbSNP
rs1293063717 36 dbSNP
rs1263081523 47 dbSNP
rs777987893 49 dbSNP
rs3758093 56 dbSNP
rs1324000184 59 dbSNP
rs1256747011 66 dbSNP
rs866406543 68 dbSNP
rs900410834 73 dbSNP
rs996888718 74 dbSNP
rs951070167 75 dbSNP
rs1448155382 77 dbSNP
rs1379849433 87 dbSNP
rs770430487 103 dbSNP
rs1028264584 110 dbSNP
rs9992 111 dbSNP
rs531609579 112 dbSNP
rs1246904917 113 dbSNP
rs550064209 114 dbSNP
rs11991204 119 dbSNP
rs118043637 123 dbSNP
rs1031809299 130 dbSNP
rs1376551673 132 dbSNP
rs956192257 136 dbSNP
rs993402372 137 dbSNP
rs1441458804 141 dbSNP
rs974814532 150 dbSNP
rs1024594027 175 dbSNP
rs1202376856 175 dbSNP
rs780815760 175 dbSNP
rs1051472 177 dbSNP
rs986634231 179 dbSNP
rs1355963882 180 dbSNP
rs979786019 186 dbSNP
rs1240102920 200 dbSNP
rs920232764 203 dbSNP
rs1243832871 207 dbSNP
rs1215028359 208 dbSNP
rs547322212 220 dbSNP
rs1043358222 224 dbSNP
rs1373061099 225 dbSNP
rs543696789 230 dbSNP
rs1173309776 231 dbSNP
rs8079 252 dbSNP
rs1054862277 254 dbSNP
rs907616000 260 dbSNP
rs1450024847 263 dbSNP
rs1335408642 268 dbSNP
rs539154452 268 dbSNP
rs774476146 270 dbSNP
rs1217652212 271 dbSNP
rs1489289809 272 dbSNP
rs944591409 274 dbSNP
rs145850436 278 dbSNP
rs1357745422 299 dbSNP
rs1286316106 303 dbSNP
rs1242978732 307 dbSNP
rs1340260070 308 dbSNP
rs900442556 309 dbSNP
rs931867423 311 dbSNP
rs1278376796 314 dbSNP
rs1293322458 325 dbSNP
rs15202 330 dbSNP
rs1026908894 340 dbSNP
rs886656665 348 dbSNP
rs1006905067 351 dbSNP
rs1049731267 354 dbSNP
rs569328074 355 dbSNP
rs536685688 367 dbSNP
rs904499210 369 dbSNP
rs1000240889 379 dbSNP
rs1392712087 382 dbSNP
rs1031755241 391 dbSNP
rs759832329 397 dbSNP
rs964667339 398 dbSNP
rs1424112179 408 dbSNP
rs1259768787 411 dbSNP
rs767676126 415 dbSNP
rs974736327 419 dbSNP
rs1261106345 421 dbSNP
rs1192648343 437 dbSNP
rs556007093 444 dbSNP
rs574302131 450 dbSNP
rs1256874775 462 dbSNP
rs1208600195 466 dbSNP
rs1356037428 468 dbSNP
rs1484265845 469 dbSNP
rs1220076238 483 dbSNP
rs531544406 486 dbSNP
rs1277188421 488 dbSNP
rs1014453292 492 dbSNP
rs1332341183 494 dbSNP
rs182286232 498 dbSNP
rs1321466613 501 dbSNP
rs760678137 513 dbSNP
rs1261590013 516 dbSNP
rs970351469 521 dbSNP
rs1467375148 529 dbSNP
rs1421667255 530 dbSNP
rs1167568224 531 dbSNP
rs1478367488 560 dbSNP
rs913726846 561 dbSNP
rs764081473 564 dbSNP
rs1468473762 566 dbSNP
rs979770738 575 dbSNP
rs1239172504 590 dbSNP
rs1027330279 596 dbSNP
rs115862902 600 dbSNP
rs983109652 605 dbSNP
rs907648270 607 dbSNP
rs79843507 611 dbSNP
rs975961997 618 dbSNP
rs1359429778 620 dbSNP
rs545542042 621 dbSNP
rs76786473 622 dbSNP
rs1377641646 626 dbSNP
rs1043585898 629 dbSNP
rs1333288162 631 dbSNP
rs1444234403 638 dbSNP
rs1361116030 643 dbSNP
rs544780903 647 dbSNP
rs949120077 655 dbSNP
rs1427324704 657 dbSNP
rs1170964627 658 dbSNP
rs1453881047 665 dbSNP
rs936036964 666 dbSNP
rs187700981 667 dbSNP
rs753796925 669 dbSNP
rs1014728887 677 dbSNP
rs1343404106 682 dbSNP
rs1210360493 685 dbSNP
rs1443844788 702 dbSNP
rs1275888977 703 dbSNP
rs1045910680 707 dbSNP
rs905990012 709 dbSNP
rs1314191906 716 dbSNP
rs1353812513 728 dbSNP
rs1311303453 732 dbSNP
rs1001787562 742 dbSNP
rs1027943552 744 dbSNP
rs149007549 747 dbSNP
rs1375831263 759 dbSNP
rs952262887 762 dbSNP
rs1449029159 770 dbSNP
rs562013392 770 dbSNP
rs1361049090 772 dbSNP
rs529211025 773 dbSNP
rs900800100 783 dbSNP
rs1160942330 785 dbSNP
rs1014982375 787 dbSNP
rs1488862956 788 dbSNP
rs1182872920 792 dbSNP
rs1473980962 795 dbSNP
rs1235325515 797 dbSNP
rs1209736082 798 dbSNP
rs1488306969 799 dbSNP
rs190953200 801 dbSNP
rs996123733 817 dbSNP
rs1030294946 818 dbSNP
rs1316324347 822 dbSNP
rs1290517363 825 dbSNP
rs976203445 830 dbSNP
rs1376734506 831 dbSNP
rs1291629697 846 dbSNP
rs1341188981 848 dbSNP
rs1219425279 852 dbSNP
rs1300179078 857 dbSNP
rs921792173 859 dbSNP
rs565539505 861 dbSNP
rs139634244 864 dbSNP
rs372751744 864 dbSNP
rs1192176902 869 dbSNP
rs532834292 879 dbSNP
rs1407383489 884 dbSNP
rs953253629 890 dbSNP
rs1434559403 898 dbSNP
rs979226051 901 dbSNP
rs925230318 927 dbSNP
rs551047578 930 dbSNP
rs1053141410 933 dbSNP
rs1485269573 947 dbSNP
rs1344089082 953 dbSNP
rs182775041 956 dbSNP
rs1419842701 962 dbSNP
rs1299941418 967 dbSNP
rs1363684594 973 dbSNP
rs564757723 990 dbSNP
rs913195232 994 dbSNP
rs369550892 996 dbSNP
rs537049680 1007 dbSNP
rs78175454 1020 dbSNP
rs905943163 1021 dbSNP
rs1158921 1022 dbSNP
rs907638512 1023 dbSNP
rs942187779 1026 dbSNP
rs1306641066 1039 dbSNP
rs1037905449 1045 dbSNP
rs1348476143 1045 dbSNP
rs900727971 1048 dbSNP
rs368346285 1049 dbSNP
rs542175500 1049 dbSNP
rs1051691214 1054 dbSNP
rs1242463886 1067 dbSNP
rs1420624661 1070 dbSNP
rs560652877 1071 dbSNP
rs1490336507 1073 dbSNP
rs1049241944 1074 dbSNP
rs1222699850 1085 dbSNP
rs369183719 1088 dbSNP
rs888048309 1113 dbSNP
rs1487498091 1117 dbSNP
rs1252146359 1119 dbSNP
rs61432164 1128 dbSNP
rs1198971583 1133 dbSNP
rs188379542 1138 dbSNP
rs1014601966 1141 dbSNP
rs1479902202 1145 dbSNP
rs1175108351 1152 dbSNP
rs1306960581 1154 dbSNP
rs1302123884 1158 dbSNP
rs553504871 1159 dbSNP
rs938003890 1161 dbSNP
rs1001074863 1162 dbSNP
rs1325846459 1164 dbSNP
rs1159968392 1175 dbSNP
rs1447922266 1181 dbSNP
rs1402951825 1184 dbSNP
rs1296065300 1185 dbSNP
rs1461216305 1200 dbSNP
rs1032181408 1201 dbSNP
rs1159227 1214 dbSNP
rs1430956041 1218 dbSNP
rs1323886714 1219 dbSNP
rs1351397738 1220 dbSNP
rs1179202753 1232 dbSNP
rs1029194677 1233 dbSNP
rs748215818 1234 dbSNP
rs1236176259 1237 dbSNP
rs1194271380 1243 dbSNP
rs1480460575 1244 dbSNP
rs1297800226 1249 dbSNP
rs1212245522 1259 dbSNP
rs953118371 1264 dbSNP
rs1377975838 1267 dbSNP
rs35561651 1274 dbSNP
rs148865649 1276 dbSNP
rs990750639 1276 dbSNP
rs1379551946 1281 dbSNP
rs1449033384 1288 dbSNP
rs979255814 1289 dbSNP
rs1304242679 1293 dbSNP
rs1402392457 1293 dbSNP
rs970784727 1293 dbSNP
rs151049294 1298 dbSNP
rs1159148291 1302 dbSNP
rs956636201 1306 dbSNP
rs1361832854 1314 dbSNP
rs988429428 1316 dbSNP
rs1424178598 1317 dbSNP
rs1257049322 1324 dbSNP
rs1229389454 1325 dbSNP
rs1484716702 1329 dbSNP
rs913233445 1332 dbSNP
rs2248718 1333 dbSNP
rs1306107977 1335 dbSNP
rs756904122 1348 dbSNP
rs1259494101 1349 dbSNP
rs1037794025 1353 dbSNP
rs922121204 1359 dbSNP
rs1314381395 1361 dbSNP
rs575854543 1363 dbSNP
rs981453748 1364 dbSNP
rs1412584840 1370 dbSNP
rs779786233 1370 dbSNP
rs1298336459 1371 dbSNP
rs1354244340 1371 dbSNP
rs932206422 1374 dbSNP
rs1051951809 1384 dbSNP
rs1237150920 1385 dbSNP
rs1458187734 1387 dbSNP
rs542997942 1391 dbSNP
rs1179904116 1393 dbSNP
rs62525317 1401 dbSNP
rs1472215031 1404 dbSNP
rs1256894006 1408 dbSNP
rs1163758147 1409 dbSNP
rs1194394191 1409 dbSNP
rs1343325188 1427 dbSNP
rs573831291 1431 dbSNP
rs1049271674 1432 dbSNP
rs4734684 1437 dbSNP
rs1357457934 1443 dbSNP
rs1267656802 1447 dbSNP
rs904567121 1458 dbSNP
rs1333782522 1470 dbSNP
rs142409192 1471 dbSNP
rs1401235136 1472 dbSNP
rs1449287923 1484 dbSNP
rs1335051434 1492 dbSNP
rs1387334734 1495 dbSNP
rs1392604057 1497 dbSNP
rs1323724770 1510 dbSNP
rs1382109961 1517 dbSNP
rs1448915186 1518 dbSNP
rs1032150353 1526 dbSNP
rs778472468 1549 dbSNP
rs1476409027 1557 dbSNP
rs1371446328 1558 dbSNP
rs894969123 1567 dbSNP
rs1012112747 1574 dbSNP
rs940957064 1577 dbSNP
rs1024892259 1579 dbSNP
rs1286440736 1580 dbSNP
rs1360531532 1591 dbSNP
rs1214305969 1592 dbSNP
rs1258247278 1601 dbSNP
rs1220135937 1605 dbSNP
rs532941401 1615 dbSNP
rs1336858927 1621 dbSNP
rs1037063110 1624 dbSNP
rs1269142091 1626 dbSNP
rs1233880701 1632 dbSNP
rs902087798 1635 dbSNP
rs1323823087 1640 dbSNP
rs997619649 1643 dbSNP
rs1439831524 1652 dbSNP
rs1400808049 1664 dbSNP
rs1332258835 1667 dbSNP
rs113277522 1673 dbSNP
rs116311110 1676 dbSNP
rs1260927280 1677 dbSNP
rs1167475980 1686 dbSNP
rs771302201 1694 dbSNP
rs530529553 1697 dbSNP
rs1239090512 1707 dbSNP
rs1032143685 1710 dbSNP
rs373384805 1712 dbSNP
rs1206169662 1718 dbSNP
rs1192584174 1723 dbSNP
rs932132515 1726 dbSNP
rs987632939 1732 dbSNP
rs1424066500 1735 dbSNP
rs1200473534 1751 dbSNP
rs912095569 1753 dbSNP
rs1301112269 1754 dbSNP
rs548918020 1761 dbSNP
rs1401821496 1768 dbSNP
rs1377333879 1771 dbSNP
rs1415072351 1772 dbSNP
rs188382470 1774 dbSNP
rs987987998 1776 dbSNP
rs946321729 1783 dbSNP
rs1025344635 1789 dbSNP
rs1343893290 1794 dbSNP
rs1399932514 1801 dbSNP
rs771285671 1805 dbSNP
rs981868126 1806 dbSNP
rs1042085599 1809 dbSNP
rs1222117853 1809 dbSNP
rs1434708677 1809 dbSNP
rs1280936583 1813 dbSNP
rs535291897 1818 dbSNP
rs1231905172 1822 dbSNP
rs1486350286 1822 dbSNP
rs936027448 1822 dbSNP
rs927250219 1828 dbSNP
rs894601162 1833 dbSNP
rs1200481860 1834 dbSNP
rs937415930 1836 dbSNP
rs1012081565 1839 dbSNP
rs1372368758 1847 dbSNP
rs1279142548 1849 dbSNP
rs1024823649 1865 dbSNP
rs1357437207 1868 dbSNP
rs984836429 1871 dbSNP
rs1361669220 1872 dbSNP
rs1414255672 1872 dbSNP
rs1161943082 1882 dbSNP
rs1399281098 1885 dbSNP
rs1407768586 1890 dbSNP
rs1163453822 1901 dbSNP
rs1004821876 1903 dbSNP
rs909296066 1906 dbSNP
rs879518453 1911 dbSNP
rs191373414 1914 dbSNP
rs1254768278 1918 dbSNP
rs1186521418 1923 dbSNP
rs1488337128 1927 dbSNP
rs571997869 1931 dbSNP
rs963064250 1938 dbSNP
rs539231719 1948 dbSNP
rs973067034 1952 dbSNP
rs1028697841 1957 dbSNP
rs1234128120 1959 dbSNP
rs953139839 1964 dbSNP
rs987560381 1975 dbSNP
rs933563010 1981 dbSNP
rs912081089 1987 dbSNP
rs79786781 1988 dbSNP
rs746357643 1990 dbSNP
rs77323659 1991 dbSNP
rs536348926 1999 dbSNP
rs538985788 2000 dbSNP
rs76649618 2003 dbSNP
rs1324698041 2009 dbSNP
rs1463349196 2010 dbSNP
rs1403447711 2020 dbSNP
rs775682042 2025 dbSNP
rs554919345 2027 dbSNP
rs1477837398 2029 dbSNP
rs1421073492 2031 dbSNP
rs573170251 2032 dbSNP
rs559162068 2040 dbSNP
rs1009839183 2042 dbSNP
rs1046636041 2046 dbSNP
rs376230623 2047 dbSNP
rs1271463857 2049 dbSNP
rs540652299 2056 dbSNP
rs971065837 2060 dbSNP
rs2515204 2078 dbSNP
rs1034356102 2079 dbSNP
rs958736483 2084 dbSNP
rs753824193 2090 dbSNP
rs909327102 2091 dbSNP
rs1304823135 2092 dbSNP
rs1489244746 2096 dbSNP
rs1392778767 2102 dbSNP
rs577558820 2104 dbSNP
rs574150263 2109 dbSNP
rs772771072 2110 dbSNP
rs1028618047 2114 dbSNP
rs1167622139 2118 dbSNP
rs796843959 2119 dbSNP
rs1452029672 2120 dbSNP
rs1201259003 2124 dbSNP
rs183861968 2132 dbSNP
rs1362326768 2138 dbSNP
rs1452312251 2139 dbSNP
rs1439130071 2143 dbSNP
rs923433198 2152 dbSNP
rs1213286867 2153 dbSNP
rs1008613602 2157 dbSNP
rs544766953 2163 dbSNP
rs967551476 2169 dbSNP
rs1307012271 2179 dbSNP
rs1281620000 2183 dbSNP
rs114522874 2212 dbSNP
rs760480881 2213 dbSNP
rs910800676 2223 dbSNP
rs765027908 2224 dbSNP
rs530600491 2229 dbSNP
rs1392340110 2239 dbSNP
rs991450775 2244 dbSNP
rs1292224215 2248 dbSNP
rs915933592 2257 dbSNP
rs867888645 2260 dbSNP
rs1045804000 2263 dbSNP
rs1394245052 2268 dbSNP
rs146626334 2284 dbSNP
rs940533137 2311 dbSNP
rs1036638924 2312 dbSNP
rs1445340733 2317 dbSNP
rs1009290879 2318 dbSNP
rs1309375138 2319 dbSNP
rs1355687165 2321 dbSNP
rs899047638 2325 dbSNP
rs1046668529 2333 dbSNP
rs906327776 2339 dbSNP
rs1264849219 2350 dbSNP
rs1002037779 2351 dbSNP
rs561073992 2357 dbSNP
rs888768103 2359 dbSNP
rs1335094514 2364 dbSNP
rs1234538648 2373 dbSNP
rs1211454756 2389 dbSNP
rs1390513758 2392 dbSNP
rs952596838 2392 dbSNP
rs1355529797 2408 dbSNP
rs767040018 2410 dbSNP
rs1008540100 2411 dbSNP
rs528051709 2412 dbSNP
rs1412386581 2421 dbSNP
rs758263335 2422 dbSNP
rs1159094682 2429 dbSNP
rs1016241819 2439 dbSNP
rs1179271988 2441 dbSNP
rs1157164840 2442 dbSNP
rs1418778752 2455 dbSNP
rs766193046 2459 dbSNP
rs1442919904 2486 dbSNP
rs1164665716 2488 dbSNP
rs1369592464 2497 dbSNP
rs1258307733 2509 dbSNP
rs962450191 2515 dbSNP
rs535075167 2521 dbSNP
rs999002382 2550 dbSNP
rs972138224 2551 dbSNP
rs1397608053 2553 dbSNP
rs1487043794 2554 dbSNP
rs1464787427 2556 dbSNP
rs1331706716 2559 dbSNP
rs868030199 2565 dbSNP
rs1237874666 2568 dbSNP
rs370781814 2570 dbSNP
rs991755411 2571 dbSNP
rs916195410 2575 dbSNP
rs11786226 2580 dbSNP
rs571961019 2581 dbSNP
rs1383901699 2582 dbSNP
rs1382491350 2584 dbSNP
rs910831683 2589 dbSNP
rs1461782077 2599 dbSNP
rs140536971 2607 dbSNP
rs940102541 2607 dbSNP
rs1167411933 2608 dbSNP
rs1255933912 2615 dbSNP
rs936901798 2623 dbSNP
rs1053398444 2628 dbSNP
rs920441291 2649 dbSNP
rs913534353 2650 dbSNP
rs1260269303 2672 dbSNP
rs2453994 2677 dbSNP
rs1469205614 2680 dbSNP
rs1274617119 2700 dbSNP
rs1211478425 2703 dbSNP
rs1333499243 2713 dbSNP
rs1050285038 2719 dbSNP
rs551146004 2722 dbSNP
rs1270326234 2727 dbSNP
rs1046188017 2733 dbSNP
rs906269327 2734 dbSNP
rs1324545419 2746 dbSNP
rs1260292316 2747 dbSNP
rs1441315807 2761 dbSNP
rs944378421 2763 dbSNP
rs1328145357 2770 dbSNP
rs1040450164 2772 dbSNP
rs780783139 2788 dbSNP
rs1054948253 2789 dbSNP
rs1482301050 2792 dbSNP
rs888380906 2793 dbSNP
rs1371792841 2796 dbSNP
rs747561626 2799 dbSNP
rs1454955188 2802 dbSNP
rs1181388029 2803 dbSNP
rs16870033 2812 dbSNP
rs1033152287 2816 dbSNP
rs1450747607 2817 dbSNP
rs192528791 2818 dbSNP
rs199646706 2819 dbSNP
rs1336919696 2829 dbSNP
rs1250660560 2830 dbSNP
rs1234992772 2831 dbSNP
rs1426091745 2835 dbSNP
rs1301070135 2841 dbSNP
rs962029740 2844 dbSNP
rs993903409 2849 dbSNP
rs1329814691 2853 dbSNP
rs576828218 2853 dbSNP
rs893297648 2853 dbSNP
rs1411688825 2873 dbSNP
rs1030449808 2878 dbSNP
rs370482991 2890 dbSNP
rs779218016 2899 dbSNP
rs1013116260 2902 dbSNP
rs746294178 2908 dbSNP
rs557102351 2911 dbSNP
rs971674478 2912 dbSNP
rs2453995 2914 dbSNP
rs1170916010 2915 dbSNP
rs1183589818 2917 dbSNP
rs1435544574 2925 dbSNP
rs1250504803 2936 dbSNP
rs1211505925 2941 dbSNP
rs201509443 2943 dbSNP
rs1402068930 2946 dbSNP
rs185121841 2952 dbSNP
rs1301776757 2954 dbSNP
rs75907193 2956 dbSNP
rs758438170 2957 dbSNP
rs775733232 2963 dbSNP
rs1444694022 2964 dbSNP
rs1334043206 2968 dbSNP
rs189953266 2973 dbSNP
rs920032581 2975 dbSNP
rs930474569 2979 dbSNP
rs985958928 2981 dbSNP
rs112383941 2995 dbSNP
rs1377736120 2996 dbSNP
rs914137597 2997 dbSNP
rs944621109 3002 dbSNP
rs1409238869 3003 dbSNP
rs1040018036 3004 dbSNP
rs1310690961 3014 dbSNP
rs1468344332 3016 dbSNP
rs1209439596 3017 dbSNP
rs747266664 3018 dbSNP
rs2515205 3019 dbSNP
rs1255266132 3020 dbSNP
rs564695020 3023 dbSNP
rs527486176 3027 dbSNP
rs765286004 3028 dbSNP
rs888246099 3030 dbSNP
rs773011510 3037 dbSNP
rs1196332693 3046 dbSNP
rs892930966 3046 dbSNP
rs758114523 3053 dbSNP
rs1425262793 3062 dbSNP
rs1287977314 3067 dbSNP
rs762889370 3071 dbSNP
rs941258957 3076 dbSNP
rs139160261 3079 dbSNP
rs1023146768 3085 dbSNP
rs897056028 3090 dbSNP
rs1346154402 3091 dbSNP
rs993540127 3093 dbSNP
rs1399340496 3102 dbSNP
rs557084692 3109 dbSNP
rs1030728954 3116 dbSNP
rs112544791 3117 dbSNP
rs1475882801 3119 dbSNP
rs1415081044 3123 dbSNP
rs1377692765 3124 dbSNP
rs1007565569 3131 dbSNP
rs1243781132 3134 dbSNP
rs1017731345 3135 dbSNP
rs1015874956 3139 dbSNP
rs1359859709 3146 dbSNP
rs1267709378 3149 dbSNP
rs961656556 3155 dbSNP
rs1337023525 3156 dbSNP
rs1299824675 3158 dbSNP
rs1310754670 3158 dbSNP
rs563668717 3162 dbSNP
rs2453996 3163 dbSNP
rs1272455688 3167 dbSNP
rs866376564 3180 dbSNP
rs1021238340 3184 dbSNP
rs967348697 3198 dbSNP
rs373908569 3202 dbSNP
rs540192696 3207 dbSNP
rs927584459 3211 dbSNP
rs1391643507 3217 dbSNP
rs1163380697 3223 dbSNP
rs755847044 3229 dbSNP
rs1238104414 3231 dbSNP
rs564877179 3233 dbSNP
rs1488915192 3234 dbSNP
rs1421508691 3243 dbSNP
rs143601723 3244 dbSNP
rs754698602 3246 dbSNP
rs1448622668 3248 dbSNP
rs990527991 3251 dbSNP
rs1194499992 3253 dbSNP
rs1253457747 3253 dbSNP
rs1469938090 3260 dbSNP
rs767017541 3264 dbSNP
rs1263918967 3269 dbSNP
rs909628335 3283 dbSNP
rs976393075 3285 dbSNP
rs116404327 3287 dbSNP
rs1405858891 3299 dbSNP
rs1190257830 3300 dbSNP
rs1275688698 3309 dbSNP
rs752254734 3312 dbSNP
rs1037259186 3318 dbSNP
rs1226900133 3327 dbSNP
rs1364900806 3328 dbSNP
rs897093135 3340 dbSNP
rs1455164320 3351 dbSNP
rs1443570523 3354 dbSNP
rs1364978743 3358 dbSNP
rs755570512 3359 dbSNP
rs914291139 3370 dbSNP
rs1051779671 3372 dbSNP
rs569566401 3375 dbSNP
rs1160455293 3382 dbSNP
rs1429105588 3382 dbSNP
rs1347892533 3387 dbSNP
rs1044553875 3388 dbSNP
rs532583269 3391 dbSNP
rs1370037761 3393 dbSNP
rs746273777 3400 dbSNP
rs548805740 3401 dbSNP
rs145966479 3409 dbSNP
rs115926851 3413 dbSNP
rs1480985820 3418 dbSNP
rs1234728801 3427 dbSNP
rs1037686206 3429 dbSNP
rs1308637688 3434 dbSNP
rs1341987663 3441 dbSNP
rs1354964653 3454 dbSNP
rs746347189 3457 dbSNP
rs376105057 3468 dbSNP
rs1310841923 3471 dbSNP
rs897437675 3472 dbSNP
rs1017677639 3473 dbSNP
rs893881143 3476 dbSNP
rs758867219 3478 dbSNP
rs1374872232 3480 dbSNP
rs1305572091 3493 dbSNP
rs1408703849 3494 dbSNP
rs1011100095 3497 dbSNP
rs1375941597 3502 dbSNP
rs1314691575 3512 dbSNP
rs1464332586 3512 dbSNP
rs1021518902 3520 dbSNP
rs1376910245 3529 dbSNP
rs967001275 3530 dbSNP
rs1175607193 3532 dbSNP
rs1419964947 3540 dbSNP
rs558503617 3564 dbSNP
rs1482781962 3570 dbSNP
rs1004168100 3571 dbSNP
rs1321465676 3573 dbSNP
rs1258780637 3598 dbSNP
rs779971370 3600 dbSNP
rs954102659 3600 dbSNP
rs1255841431 3601 dbSNP
rs1006944858 3607 dbSNP
rs17200931 3610 dbSNP
rs1227205681 3618 dbSNP
rs959064805 3622 dbSNP
rs62525328 3623 dbSNP
rs966254749 3627 dbSNP
rs1394274319 3629 dbSNP
rs537885268 3643 dbSNP
rs990475586 3654 dbSNP
rs909661073 3655 dbSNP
rs1289160704 3656 dbSNP
rs1455162112 3665 dbSNP
rs747319724 3676 dbSNP
rs1469546661 3681 dbSNP
rs556955719 3682 dbSNP
rs975981610 3686 dbSNP
rs768928769 3687 dbSNP
rs1190692392 3690 dbSNP
rs182189488 3703 dbSNP
rs955991223 3704 dbSNP
rs914253672 3724 dbSNP
rs776714665 3725 dbSNP
rs1044149564 3735 dbSNP
rs1207776125 3741 dbSNP
rs933927654 3746 dbSNP
rs1274575058 3760 dbSNP
rs186262047 3762 dbSNP
rs911130845 3766 dbSNP
rs1339743401 3767 dbSNP
rs769741685 3769 dbSNP
rs1296232390 3791 dbSNP
rs554756658 3794 dbSNP
rs1318758895 3798 dbSNP
rs549722163 3821 dbSNP
rs897359364 3828 dbSNP
rs1165019654 3830 dbSNP
rs1011381654 3832 dbSNP
rs1456477258 3838 dbSNP
rs1368362845 3845 dbSNP
rs1194574996 3850 dbSNP
rs1165240511 3852 dbSNP
rs138622246 3856 dbSNP
rs1042567435 3874 dbSNP
rs773241105 3878 dbSNP
rs1246640481 3883 dbSNP
rs1187531632 3884 dbSNP
rs1468588898 3893 dbSNP
rs1274674589 3895 dbSNP
rs80063182 3904 dbSNP
rs564833491 3905 dbSNP
rs532815009 3922 dbSNP
rs1331008711 3925 dbSNP
rs1377726030 3930 dbSNP
rs1229584536 3941 dbSNP
rs1006871265 3945 dbSNP
rs1296514962 3946 dbSNP
rs1449154235 3964 dbSNP
rs61254141 3966 dbSNP
rs901292776 3977 dbSNP
rs1385126354 3984 dbSNP
rs188680008 3997 dbSNP
rs1390174570 4000 dbSNP
rs1168988133 4019 dbSNP
rs1229191748 4023 dbSNP
rs1292477511 4033 dbSNP
rs374145358 4040 dbSNP
rs1454996179 4041 dbSNP
rs1248051474 4043 dbSNP
rs1031506273 4047 dbSNP
rs1450514729 4054 dbSNP
rs1250686442 4055 dbSNP
rs2132862 4068 dbSNP
rs962504876 4069 dbSNP
rs1273858338 4071 dbSNP
rs1234703653 4072 dbSNP
rs990052604 4073 dbSNP
rs1276809544 4074 dbSNP
rs1231416424 4075 dbSNP
rs531940851 4077 dbSNP
rs1329542877 4079 dbSNP
rs1369192002 4080 dbSNP
rs1411751394 4080 dbSNP
rs969708376 4102 dbSNP
rs979826183 4104 dbSNP
rs1427754320 4105 dbSNP
rs918342286 4106 dbSNP
rs928338645 4108 dbSNP
rs938445717 4111 dbSNP
rs955418500 4115 dbSNP
rs1183653052 4123 dbSNP
rs1481805535 4126 dbSNP
rs1250948892 4129 dbSNP
rs567078774 4137 dbSNP
rs1473262715 4142 dbSNP
rs1472432685 4146 dbSNP
rs918774358 4150 dbSNP
rs527748895 4161 dbSNP
rs552239306 4162 dbSNP
rs931512624 4163 dbSNP
rs1280379077 4165 dbSNP
rs1230257023 4193 dbSNP
rs759335628 4195 dbSNP
rs1288243516 4200 dbSNP
rs755107203 4200 dbSNP
rs942697065 4205 dbSNP
rs4734685 4211 dbSNP
rs911163665 4215 dbSNP
rs942600559 4223 dbSNP
rs1414281846 4228 dbSNP
rs570641367 4232 dbSNP
rs1385177437 4245 dbSNP
rs1039025934 4262 dbSNP
rs1471313581 4263 dbSNP
rs915195180 4265 dbSNP
rs1170210291 4272 dbSNP
rs946822792 4291 dbSNP
rs901214639 4296 dbSNP
rs1042904353 4298 dbSNP
rs1401341615 4302 dbSNP
rs902586616 4303 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 528.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 528.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000395862.3 | 3UTR | UUCACCCAUUUCAAUAUUGCACUUAUUAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000395862.3 | 3UTR | UUCACCCAUUUCAAUAUUGCACUUAUUAAUGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.668 6.4e-4 0.851 9.9e-7 20 Click to see details
GSE17498 Multiple myeloma 0.468 1.2e-3 0.384 7.2e-3 40 Click to see details
GSE21687 Ependynoma primary tumors 0.259 1.9e-2 0.249 2.4e-2 64 Click to see details
GSE19536 Breast cancer 0.17 4.5e-2 0.051 3.1e-1 100 Click to see details
GSE38226 Liver fibrosis -0.377 4.6e-2 -0.152 2.6e-1 21 Click to see details
GSE19783 ER- ER- breast cancer 0.19 4.7e-2 0.081 2.4e-1 79 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.567 5.6e-2 -0.317 2.0e-1 9 Click to see details
GSE42095 Differentiated embryonic stem cells -0.321 6.8e-2 -0.241 1.3e-1 23 Click to see details
GSE28544 Breast cancer 0.285 8.9e-2 0.271 1.0e-1 24 Click to see details
GSE28260 Renal cortex and medulla -0.348 1.2e-1 -0.242 2.1e-1 13 Click to see details
GSE19783 ER+ ER+ breast cancer 0.208 1.9e-1 -0.053 4.1e-1 20 Click to see details
GSE32688 Pancreatic cancer 0.155 2.0e-1 0.238 9.5e-2 32 Click to see details
GSE19350 CNS germ cell tumors 0.185 2.8e-1 0.147 3.2e-1 12 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.098 3.2e-1 0.314 6.3e-2 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.051 4.0e-1 -0.113 3.0e-1 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.027 4.5e-1 0.049 4.1e-1 24 Click to see details
GSE21032 Prostate cancer 0.001 5.0e-1 0.037 3.7e-1 83 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.503 0 -0.466 0 38 Click to see details
PCPG 0.998 0.02 1.000 0.5 3 Click to see details
HNSC -0.311 0.02 -0.257 0.05 42 Click to see details
BRCA -0.211 0.03 -0.123 0.13 83 Click to see details
KICH 0.379 0.03 0.338 0.05 25 Click to see details
THCA -0.193 0.07 -0.089 0.25 59 Click to see details
LUAD -0.427 0.08 -0.378 0.11 12 Click to see details
BLCA 0.285 0.13 0.129 0.3 18 Click to see details
CHOL 0.414 0.13 0.333 0.19 9 Click to see details
LIHC -0.122 0.2 -0.047 0.37 49 Click to see details
CESC 0.724 0.24 0.500 0.33 3 Click to see details
ESCA 0.093 0.39 0.055 0.44 11 Click to see details
PAAD -0.193 0.4 0.200 0.4 4 Click to see details
KIRP 0.042 0.41 -0.033 0.43 32 Click to see details
STAD 0.041 0.41 0.123 0.25 31 Click to see details
KIRC 0.026 0.42 0.006 0.48 68 Click to see details
UCEC 0.04 0.44 0.114 0.32 19 Click to see details
PRAD 0.019 0.45 -0.027 0.43 48 Click to see details
PRAD 0.019 0.45 -0.027 0.43 48 Click to see details
PRAD 0.019 0.45 -0.027 0.43 48 Click to see details
75 hsa-miR-16-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004488 RARB retinoic acid receptor beta 3 1
MIRT038707 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 1 1
MIRT057208 PPIF peptidylprolyl isomerase F 2 4
MIRT058726 RSBN1 round spermatid basic protein 1 2 8
MIRT074502 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 4
MIRT081544 ZNF431 zinc finger protein 431 2 4
MIRT096893 ERBB2IP erbb2 interacting protein 2 2
MIRT105124 MYC MYC proto-oncogene, bHLH transcription factor 2 2
MIRT107898 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT109432 KLHL15 kelch like family member 15 2 6
MIRT166742 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 6
MIRT171257 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 2 2
MIRT192760 B2M beta-2-microglobulin 2 2
MIRT194905 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT215599 SUB1 SUB1 homolog, transcriptional regulator 2 2
MIRT223632 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT241605 AMOTL1 angiomotin like 1 2 4
MIRT291174 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT444286 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT463285 ZFX zinc finger protein, X-linked 2 4
MIRT471759 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT479611 CDC25A cell division cycle 25A 2 2
MIRT481497 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 8
MIRT483117 SH3BP5 SH3 domain binding protein 5 2 2
MIRT502279 GRPEL2 GrpE like 2, mitochondrial 2 8
MIRT507838 CCNT1 cyclin T1 2 2
MIRT508179 MTRNR2L6 MT-RNR2-like 6 2 4
MIRT510576 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 6
MIRT517853 RPS4X ribosomal protein S4, X-linked 2 4
MIRT521690 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT525070 FRK fyn related Src family tyrosine kinase 2 2
MIRT527082 UBE2E3 ubiquitin conjugating enzyme E2 E3 2 2
MIRT529552 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530426 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT533909 TBC1D15 TBC1 domain family member 15 2 2
MIRT536627 IPO7 importin 7 2 2
MIRT537647 ERGIC2 ERGIC and golgi 2 2 4
MIRT538512 CLCN3 chloride voltage-gated channel 3 2 2
MIRT539219 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT539348 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT539954 CCT4 chaperonin containing TCP1 subunit 4 2 2
MIRT541208 HOXA10 homeobox A10 2 2
MIRT543216 TMEM117 transmembrane protein 117 2 2
MIRT543399 DROSHA drosha ribonuclease III 2 2
MIRT546648 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT546852 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT549917 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT552998 USP46 ubiquitin specific peptidase 46 2 2
MIRT555254 PREPL prolyl endopeptidase-like 2 2
MIRT555956 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT557095 HOXA9 homeobox A9 2 2
MIRT561396 TUBB2A tubulin beta 2A class IIa 2 2
MIRT561654 RNF219 ring finger protein 219 2 2
MIRT563101 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT565979 RNF44 ring finger protein 44 2 2
MIRT572396 CCDC14 coiled-coil domain containing 14 2 2
MIRT574400 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT607623 VSNL1 visinin like 1 2 2
MIRT610645 CTGF connective tissue growth factor 2 2
MIRT623379 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT624687 AR androgen receptor 2 2
MIRT632089 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT644216 CBS cystathionine-beta-synthase 2 2
MIRT647841 BID BH3 interacting domain death agonist 2 2
MIRT651649 WASF2 WAS protein family member 2 2 2
MIRT689064 AGMAT agmatinase 2 2
MIRT698150 TNPO1 transportin 1 2 2
MIRT700516 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT704081 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT705970 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT715694 COMMD3-BMI1 COMMD3-BMI1 readthrough 2 2
MIRT717184 BMI1 BMI1 proto-oncogene, polycomb ring finger 2 2
MIRT724607 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT724854 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT725401 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-16-2 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-16-2-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HCT-116)
hsa-miR-16-2-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-16-2-3p Bortezomib 387447 NSC681239 approved resistant Low Multiple Myeloma tissue
hsa-miR-16-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-16-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-16-2-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-16-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (HCT8)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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