miRTarBase - #MIRT226211


—
pre-miRNA Information
pre-miRNA hsa-mir-4529   
Genomic Coordinates chr18: 55479221 - 55479298
Description Homo sapiens miR-4529 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4529-5p
Sequence 6| AGGCCAUCAGCAGUCCAAUGAA |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1325288049 1 dbSNP
rs1233088462 15 dbSNP
rs1324866273 19 dbSNP
Putative Targets

Gene Information
Gene Symbol TMEM64   
Synonyms -
Description transmembrane protein 64
Transcript NM_001008495   
Other Transcripts NM_001146273   
Expression
Putative miRNA Targets on TMEM64
3'UTR of TMEM64
(miRNA target sites are highlighted)		 
>TMEM64|NM_001008495|3'UTR
   1 TTCTAATGAGATACGTGATTGTCAAGAGCCTAGTGTGCTATCTAAGGTCTAGCAGTCACTTCACTAGTGGGCAGAGACAA
  81 GTTCTAATTGTATTACAGCACAAACAAAACTGACTAGTTTTTAAATTGCACAATTTTTTTTTTTTAAAGCAAGAATCATT
 161 TTCTGGGTATGTAAGTGTAAATGTAGATGCAAATTTGGCTGCACCTCTTTATCATGCCTGTATTGGCCTATAGGTCTGCA
 241 CTTTAGTGTTTTTTAATTGTTTTATTTCTGTGTATTTACGAACAGAGAAATAACCCAAATATTATTTCTGCTTAGTGTCT
 321 TTATTTATAAAGCCCATGAGTAGTTTGTATGCATCTTTCCTACTTGTAAAGATGAGTAAAAGTATGCAGTTTTAAATTTA
 401 TAATATTATTGGATGTTCTTTGCTTTGGTAGTCTTTCCAGAAAGGATAAACAGTGGTTTTTGTTTTGTTTTGTTTTATTG
 481 TTTAAGTGGGACCACTTAGCTTCCCGTTTCCTTACTAGTTAAAGAACAGACATTAATTTTCAGTTGAATGTATTTTTGCA
 561 GGCATCATATTGTTACAGGGCCATTTACACCTATTCACAAAGCTTAAATCCTACCTTGTGGGACTGAAGTGCTCTTAATA
 641 TAACTGTTTATTTTCACTGTGTAATATGCAAAGCAAAAGGGAAATTATTTGGTGGATGGTAGCTCAAAATTGGAACTCTT
 721 GTTCTAATTCAGTTACATTGGCTTTACCCTCCTTAGATTTTTCATCAAAGGGCTGTCCCATTGCAATCTTACTAAAACAT
 801 TTTGTTAAAATAAACTCTTTTCCTTTTTATATTAATAATTAGGCTTTTAAATAAAGATGTTATTCCTTTAAAATGGTGGG
 881 CTTACCATCATTGAAGATGTCACTCAGGTGGCCTTGTTTGATCAAAACGCCTTTTTTAAAAACCAAGCTTTAAAAACATG
 961 TTTATAATTTCATGAAGTACATATATATTGTTCCCATAGTCTTCAGCTTTAAAACTATAAATATGCCCAAATTTTGTTAT
1041 TTGCCCTACTTTAAGTAGGTTTATTGTGTTTGTTTTTTCAGTACTTGTTTTTCTCTGATAAGACTCAGGAATTCTGAAAT
1121 GTGAAATTGTCTCAATTCTTTCTCTTGTAGCATGAATCAAATGTATTTATTAATAGCACTTATGACTATAGAATATAATT
1201 TGGCATATGATTCATATTACATATGTATTCGTTTTATTTTTAAAATAGTTTATAAACTTAATGATTTTTTTTTACAAATG
1281 AGGTTATAGATATTAATGCAAATTTTCTGGTAGGTATCTCTTTTTTTGCTATGATGATTCCAACTTATCAGAGACCTCCC
1361 ATTTGCCTTTTCATTACGGTGAAAGCTTTGCCCTCATCTACTAAAGTACAAAGGAATTCTTTGGAAGCAGATTATTCTAG
1441 TCTTATGCTAGAGATGAATTTGATCATTTTAATGTGTGATCTTTTTGCTCTATCAGGTATAATTGTTTTCCTTTCCTTTA
1521 TAATGGGTAAGTTTTCTCACCTTTGAGTAACAGTAAAGTTCATTTATATGTCCATACCTAGAAGACCAGTGCAAATACTT
1601 TGAGAGCACCTGGGTCTACAGGACATAATTGGCATCTAAATCCTCATTTCTTGCTATTAGTAGGAAAACAGATATAGTAT
1681 TGTAATACCCTTATTCTTTTTGAATCCTAATTACTCATTTCGGTTTTTTTTCTCTCTTTTGAATCTAGTTGCTGGTTTTC
1761 GTTTAATGATTTTAGTTTAACAATCCCAACCAACAATACATTTGATTTATTTTTTTCTGTCTAACCTGACAACCTTTTTC
1841 TTGTGCTTCTTGTTTGTTGGTTAGTTTTTGTGAAAGGAATCATTGTTTAAGATCACTGTTTTCATACTTGTTTTACACTT
1921 CACGTATTTTGAAGTACATTTATTTACTAAGCATTTGTGACTTGAATAATTTCACCAAATGAATACATTTTGGTAGTTTG
2001 TAATGAGTTCTTCTAATTGTTACACTTTGCTTGGTACTTAACAATAAATATGTAAAGGTAAAAGAAATAATTTTCTGTAT
2081 TCTGCCAATCTTAATTTTATATAATAAATCATCCATTTTTTTCTTAAAATAGTATGGATTGACTGTTTCTAAAATACCAA
2161 TCTGTGGCTGTGGTTTTTCTTTTCTTCAGCATTTCCAGCATCCAAGTAAACAATAGTCCCTTATAGTCCTGCTACTTGAT
2241 GGGTAAATTTGGTTGCTGGGTTTTTAAGTTGCACTCACAATAAATCGTGCAAAGCATTGTCATGCCTTATTTACTCCATT
2321 TTTAATCCTGCATCCCAGATTTATGGCAGCAACACATATCTACAGGATACTTTTATGTTGTCCAAATATTGCTGTCAGTC
2401 ATATGTACTTATAAAATGTCTCCACTCATGTATATTTATAGAAATGAAATGTCAAATTTCTCAGACTGTTAAAGTGCAGT
2481 ATAAAGTTGCTTAATGCACACTTAAAAATGATATATAATTTCTGAATCCTATGAAATATGTGTTCTTTTTTAATTCTTTG
2561 GGAGTTTTCTTAAGTTTTACATGTTTTTTGGTTTATTGTTAATGATTTTGTTTACTCTTTGCCAAATTTTGTCATGTAGG
2641 TTATTTTACAATAGCACCTTTAAAAAAAATGTATATGCTAATTTACTAAGCATATTCATGTCCATTTTTATTTGATCATC
2721 TGATTTGTGAAATAACTTGAAATTTGTACTGTTTGGTTTGTGAAAATAATATTACCAAATCTCTGTCATTAGAATGTGTA
2801 CTTTATGTTCAGAAGTGACTGTGGGTTTATTCAGAGCCAGCCATTCTCTCCCTTGATGCACTTTGTAACCAGCTACACAT
2881 GCTTTTAGGTGGCTTTTCCCTGATAGGGTCAAGTATATGACTATAAAACATTTTTCTTGTGAAGCTATTAAGTTCATTAG
2961 TTACTCTTATTTCCCCTTGTTGTAACTAAGTGGTGCAGGTATAAGCATATCCCCAGCATTCCTGTGTGTGTGAATGTGCA
3041 CTGCTGATTTGGACTGTTCTTGAGAAAGGTGCTGTGACATATGTCAATATTTGTTAGCTCTGGGGATATCTTTAGAATGC
3121 TTGAGAAAGTTGCTAGGTGTGTGCCACATTGGTGCAGGTAAATCCATGCTGTTCACAGCCAAGCAGCATTTGCAGAGAAA
3201 AGGAGAGTTTTACATAGACCCCAGGAAAAACAGTACTAACCTGGTTGATGGCCTTGGTGGTGGAATTTTGTTTCAGCCAG
3281 AGGCTACTCATTATATCAGAATGATGTTCAGTATAACACTATCTGATTTTTAGATTGGTCGATTTCTGTTGTAATCAAGT
3361 ATTTAGGATGTAATCTTTTTAAAGTCATTGCTTTAATCTGAAAAGCCATTAGAAGGGAGAGGAATCACTGTTCCACAGGA
3441 TATTTAAAACTCAGGAGTTCAAATAACCTCACATATTGAACATAAACTGTTAACTTATTCCACAACTAAATTCTAACCTG
3521 ATACTTATGAATTGCAAAGTGATTGCTGCAAACTTTTTCTAAGGTGGCTGAAGATTTAAAATAGATCATTCTAAAGGGAA
3601 ATCAGTAAAATGTCTTGATAATTGGTATCCAAATCACTTGTGTGCCTGAGAAAATAAAAGGTAATATTTTACTTTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaguaaccuGA-CGACUACCGGa 5'
                   || |:|||||||| 
Target 5' agtactaacCTGGTTGATGGCCt 3'
 3232 - 3254 153.00 -18.00
2 
miRNA  3' aaGUAAC--CUGAC---GA--CUACCGGa 5'
            |||||  || ||   ||  |:||||| 
Target 5' atCATTGAAGA-TGTCACTCAGGTGGCCt 3'
 887 - 914 139.00 -17.00
3 
miRNA  3' aaGUAACCUGACG----ACUACCgga 5'
            :|| |  ||||    ||||||   
Target 5' ctTATAGTCCTGCTACTTGATGGgta 3'
 2220 - 2245 118.00 -9.82
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30171542 8 COSMIC
COSN31554376 14 COSMIC
COSN30175866 15 COSMIC
COSN30525559 33 COSMIC
COSN6369223 44 COSMIC
COSN30131934 47 COSMIC
COSN9687231 75 COSMIC
COSN30503984 80 COSMIC
COSN31608936 108 COSMIC
COSN31587126 133 COSMIC
COSN18733115 134 COSMIC
COSN20070366 134 COSMIC
COSN31606563 143 COSMIC
COSN15660452 146 COSMIC
COSN31589116 233 COSMIC
COSN27135808 234 COSMIC
COSN31515130 287 COSMIC
COSN4942765 433 COSMIC
COSN30170829 624 COSMIC
COSN30175042 698 COSMIC
COSN31588063 705 COSMIC
COSN26575647 746 COSMIC
COSN21391620 856 COSMIC
COSN31486613 856 COSMIC
COSN30538964 865 COSMIC
COSN17076105 886 COSMIC
COSN31588037 928 COSMIC
COSN31517919 929 COSMIC
COSN26549607 980 COSMIC
COSN31521452 1044 COSMIC
COSN30173239 1106 COSMIC
COSN31486856 1144 COSMIC
COSN31550549 1144 COSMIC
COSN19687327 1157 COSMIC
COSN31601133 1230 COSMIC
COSN17429056 1419 COSMIC
COSN21006895 1761 COSMIC
COSN30174757 1973 COSMIC
COSN8109994 2060 COSMIC
COSN20870036 2131 COSMIC
COSN30176494 2179 COSMIC
COSN31480564 2184 COSMIC
COSN30174292 2187 COSMIC
COSN17804101 2208 COSMIC
COSN32055728 2776 COSMIC
COSN26894962 3024 COSMIC
COSN1369625 3037 COSMIC
COSN9461040 3105 COSMIC
COSN9687230 3627 COSMIC
COSN22480584 3659 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1385377553 7 dbSNP
rs762859132 11 dbSNP
rs770209715 12 dbSNP
rs1316246878 13 dbSNP
rs776823600 14 dbSNP
rs1274430962 15 dbSNP
rs1220906015 26 dbSNP
rs200849109 28 dbSNP
rs1324987500 32 dbSNP
rs368397424 34 dbSNP
rs780439010 35 dbSNP
rs1290680750 36 dbSNP
rs566720589 39 dbSNP
rs372874818 44 dbSNP
rs759995650 45 dbSNP
rs1157469834 47 dbSNP
rs551929500 53 dbSNP
rs1241371325 59 dbSNP
rs1474541988 62 dbSNP
rs999018296 63 dbSNP
rs902844872 89 dbSNP
rs1420231368 94 dbSNP
rs62526888 132 dbSNP
rs1174434264 133 dbSNP
rs79683844 134 dbSNP
rs1408902084 142 dbSNP
rs1318062122 146 dbSNP
rs879893663 146 dbSNP
rs1343820615 152 dbSNP
rs893954960 165 dbSNP
rs1052588808 171 dbSNP
rs1340541180 186 dbSNP
rs1042783338 187 dbSNP
rs1280851963 190 dbSNP
rs1325581461 199 dbSNP
rs1201022790 204 dbSNP
rs555256436 220 dbSNP
rs571504592 242 dbSNP
rs1319047924 246 dbSNP
rs762284742 263 dbSNP
rs935506088 270 dbSNP
rs1056135760 279 dbSNP
rs763125760 280 dbSNP
rs1228177501 283 dbSNP
rs1431616568 293 dbSNP
rs982370650 294 dbSNP
rs947697116 295 dbSNP
rs879035593 297 dbSNP
rs1383213227 322 dbSNP
rs549995793 328 dbSNP
rs1319446622 332 dbSNP
rs1360728505 332 dbSNP
rs1404020793 335 dbSNP
rs1300731060 345 dbSNP
rs531357071 347 dbSNP
rs1315383124 352 dbSNP
rs984262714 356 dbSNP
rs952465008 360 dbSNP
rs918349742 366 dbSNP
rs1047133096 379 dbSNP
rs1286556050 382 dbSNP
rs1490244239 383 dbSNP
rs1220559068 384 dbSNP
rs1271064819 386 dbSNP
rs965192144 387 dbSNP
rs1417463491 389 dbSNP
rs1346662449 403 dbSNP
rs1249956187 406 dbSNP
rs1181662719 411 dbSNP
rs188388665 417 dbSNP
rs1423074552 419 dbSNP
rs548970062 428 dbSNP
rs1159502576 430 dbSNP
rs1385063523 439 dbSNP
rs527302864 449 dbSNP
rs1475539469 452 dbSNP
rs1262589529 453 dbSNP
rs964029435 454 dbSNP
rs559697200 457 dbSNP
rs1194289402 477 dbSNP
rs1366848126 477 dbSNP
rs1214619719 478 dbSNP
rs953484706 489 dbSNP
rs1327651215 500 dbSNP
rs183059565 505 dbSNP
rs1261573741 506 dbSNP
rs1309642497 522 dbSNP
rs1221268171 532 dbSNP
rs1320325398 534 dbSNP
rs987462584 536 dbSNP
rs955534023 540 dbSNP
rs1294250973 541 dbSNP
rs1011339163 545 dbSNP
rs893868832 548 dbSNP
rs1248587516 562 dbSNP
rs189595628 576 dbSNP
rs1242846573 578 dbSNP
rs1052525565 591 dbSNP
rs1386676016 602 dbSNP
rs998613346 605 dbSNP
rs544794904 610 dbSNP
rs117973485 613 dbSNP
rs754117301 616 dbSNP
rs1331999984 622 dbSNP
rs1381711992 630 dbSNP
rs185123224 638 dbSNP
rs534200071 650 dbSNP
rs1380065171 657 dbSNP
rs1386648874 659 dbSNP
rs1227037988 661 dbSNP
rs181850943 664 dbSNP
rs1341565600 666 dbSNP
rs1457186724 687 dbSNP
rs1389317089 695 dbSNP
rs76275800 699 dbSNP
rs191084681 702 dbSNP
rs1460408910 707 dbSNP
rs918308047 710 dbSNP
rs539983178 715 dbSNP
rs972489948 718 dbSNP
rs1003234422 721 dbSNP
rs907031868 737 dbSNP
rs1422915115 746 dbSNP
rs1370804854 751 dbSNP
rs1478530707 754 dbSNP
rs1170837523 755 dbSNP
rs1405220153 756 dbSNP
rs1468225449 761 dbSNP
rs912418692 773 dbSNP
rs985331054 776 dbSNP
rs1381796616 781 dbSNP
rs1293740574 783 dbSNP
rs1328225679 784 dbSNP
rs1191559859 791 dbSNP
rs953959432 803 dbSNP
rs1322018913 815 dbSNP
rs1206139271 817 dbSNP
rs1021980407 819 dbSNP
rs1256888576 819 dbSNP
rs1047360146 839 dbSNP
rs768766472 851 dbSNP
rs1259210654 852 dbSNP
rs930050957 855 dbSNP
rs958289214 856 dbSNP
rs1428054607 863 dbSNP
rs1479380920 866 dbSNP
rs1262645166 875 dbSNP
rs1190833198 883 dbSNP
rs1031086379 884 dbSNP
rs866940716 887 dbSNP
rs1452817583 888 dbSNP
rs1286950476 901 dbSNP
rs919983545 903 dbSNP
rs1387374903 913 dbSNP
rs1400903412 918 dbSNP
rs760661039 928 dbSNP
rs1343727470 929 dbSNP
rs1225850066 944 dbSNP
rs1302617494 950 dbSNP
rs1038438367 952 dbSNP
rs1214777758 958 dbSNP
rs1237301280 958 dbSNP
rs1262932246 961 dbSNP
rs1489056830 981 dbSNP
rs1216899487 985 dbSNP
rs569374880 988 dbSNP
rs1489655436 994 dbSNP
rs551052112 996 dbSNP
rs942667575 1000 dbSNP
rs185791596 1012 dbSNP
rs911221549 1014 dbSNP
rs1156653868 1015 dbSNP
rs1381954352 1016 dbSNP
rs1224544341 1019 dbSNP
rs1420469371 1021 dbSNP
rs987062405 1036 dbSNP
rs934278153 1048 dbSNP
rs1438679012 1052 dbSNP
rs930985670 1059 dbSNP
rs918291442 1063 dbSNP
rs1390222444 1068 dbSNP
rs1309526169 1081 dbSNP
rs1354870041 1086 dbSNP
rs376794052 1091 dbSNP
rs551864348 1105 dbSNP
rs924116154 1106 dbSNP
rs1356887683 1107 dbSNP
rs978636288 1114 dbSNP
rs968224952 1115 dbSNP
rs1021345737 1116 dbSNP
rs912325745 1123 dbSNP
rs1368412219 1124 dbSNP
rs182121033 1129 dbSNP
rs1440104206 1133 dbSNP
rs1182813484 1144 dbSNP
rs1383588520 1147 dbSNP
rs1407364214 1152 dbSNP
rs1441419609 1163 dbSNP
rs1354021837 1169 dbSNP
rs534821983 1172 dbSNP
rs1166110883 1189 dbSNP
rs1333984998 1191 dbSNP
rs1378045438 1192 dbSNP
rs567507418 1196 dbSNP
rs914462398 1201 dbSNP
rs1175523563 1206 dbSNP
rs1229691811 1208 dbSNP
rs530669901 1209 dbSNP
rs1289889340 1213 dbSNP
rs1306446580 1220 dbSNP
rs1259892905 1221 dbSNP
rs1458192034 1229 dbSNP
rs12545351 1231 dbSNP
rs1473863191 1240 dbSNP
rs1182664470 1248 dbSNP
rs1194626432 1248 dbSNP
rs1172971221 1260 dbSNP
rs1426835323 1260 dbSNP
rs115035400 1261 dbSNP
rs1284448797 1263 dbSNP
rs1449717487 1263 dbSNP
rs761222767 1263 dbSNP
rs1216222017 1265 dbSNP
rs1360901605 1265 dbSNP
rs1279619103 1274 dbSNP
rs536655607 1274 dbSNP
rs1034467692 1278 dbSNP
rs1222842985 1279 dbSNP
rs1260944345 1280 dbSNP
rs1443956887 1286 dbSNP
rs1211025072 1292 dbSNP
rs1002774251 1301 dbSNP
rs550959526 1302 dbSNP
rs1195928220 1312 dbSNP
rs1236840031 1314 dbSNP
rs1198086000 1316 dbSNP
rs907144560 1318 dbSNP
rs1415383271 1319 dbSNP
rs1251373180 1323 dbSNP
rs1231980801 1326 dbSNP
rs1345255668 1328 dbSNP
rs1025574905 1336 dbSNP
rs1305241224 1337 dbSNP
rs1344236331 1346 dbSNP
rs1397817549 1347 dbSNP
rs993940129 1348 dbSNP
rs1340597201 1354 dbSNP
rs898338997 1359 dbSNP
rs1222776987 1362 dbSNP
rs1038384029 1368 dbSNP
rs1273025779 1372 dbSNP
rs1347096480 1373 dbSNP
rs942822018 1377 dbSNP
rs775627058 1378 dbSNP
rs532720652 1398 dbSNP
rs1051557532 1401 dbSNP
rs745620873 1406 dbSNP
rs1263947009 1408 dbSNP
rs1490213726 1431 dbSNP
rs1197424859 1432 dbSNP
rs190051174 1441 dbSNP
rs924164055 1453 dbSNP
rs1302302367 1470 dbSNP
rs1432988351 1472 dbSNP
rs1027234416 1474 dbSNP
rs1397064477 1476 dbSNP
rs978341319 1492 dbSNP
rs1321055542 1496 dbSNP
rs1174528781 1498 dbSNP
rs759601203 1499 dbSNP
rs529832484 1500 dbSNP
rs996183491 1502 dbSNP
rs1278676381 1512 dbSNP
rs12545279 1526 dbSNP
rs1036628064 1527 dbSNP
rs1184501416 1530 dbSNP
rs1438898452 1531 dbSNP
rs1256120169 1533 dbSNP
rs1199367098 1538 dbSNP
rs1292193467 1539 dbSNP
rs374193916 1554 dbSNP
rs1231489647 1555 dbSNP
rs958722851 1566 dbSNP
rs1049951883 1569 dbSNP
rs1380494810 1570 dbSNP
rs879113966 1581 dbSNP
rs1034004908 1589 dbSNP
rs1423677467 1590 dbSNP
rs1160936190 1592 dbSNP
rs932495254 1601 dbSNP
rs1392276411 1616 dbSNP
rs1405816329 1617 dbSNP
rs981487184 1629 dbSNP
rs1448681193 1645 dbSNP
rs1334660051 1654 dbSNP
rs971107406 1662 dbSNP
rs1352600121 1666 dbSNP
rs1025945255 1671 dbSNP
rs1242905207 1675 dbSNP
rs990068005 1679 dbSNP
rs1357185968 1688 dbSNP
rs574200611 1696 dbSNP
rs898326204 1703 dbSNP
rs1016764034 1710 dbSNP
rs1277551375 1711 dbSNP
rs1184965461 1721 dbSNP
rs1369643344 1722 dbSNP
rs1006912304 1724 dbSNP
rs924539376 1729 dbSNP
rs562122634 1732 dbSNP
rs978046500 1732 dbSNP
rs1331725151 1735 dbSNP
rs796911146 1736 dbSNP
rs1405094814 1737 dbSNP
rs1311945628 1738 dbSNP
rs549411713 1742 dbSNP
rs540959666 1748 dbSNP
rs770744523 1757 dbSNP
rs1313656032 1760 dbSNP
rs1051205478 1761 dbSNP
rs1276459535 1767 dbSNP
rs1419318090 1775 dbSNP
rs573572686 1804 dbSNP
rs1383165170 1808 dbSNP
rs73692313 1810 dbSNP
rs1262838423 1813 dbSNP
rs1482499747 1832 dbSNP
rs16904999 1843 dbSNP
rs772904999 1848 dbSNP
rs567407245 1849 dbSNP
rs1442709022 1850 dbSNP
rs946988824 1856 dbSNP
rs1420852600 1860 dbSNP
rs1186464897 1861 dbSNP
rs995703156 1862 dbSNP
rs897389429 1881 dbSNP
rs1171332791 1896 dbSNP
rs915391892 1898 dbSNP
rs1055328054 1904 dbSNP
rs938205060 1911 dbSNP
rs1464340353 1920 dbSNP
rs1015802612 1923 dbSNP
rs748855052 1924 dbSNP
rs981219353 1937 dbSNP
rs1487739413 1938 dbSNP
rs971439883 1940 dbSNP
rs1174247969 1957 dbSNP
rs1401101140 1965 dbSNP
rs1283180849 1968 dbSNP
rs1310996626 1976 dbSNP
rs777241841 1981 dbSNP
rs1281762204 1983 dbSNP
rs1235879959 1986 dbSNP
rs1257012516 1993 dbSNP
rs1345212350 1999 dbSNP
rs1049493091 2003 dbSNP
rs932419645 2018 dbSNP
rs1206618654 2035 dbSNP
rs1260351088 2037 dbSNP
rs892897353 2037 dbSNP
rs747807105 2044 dbSNP
rs1283455778 2051 dbSNP
rs1431439600 2051 dbSNP
rs184786433 2052 dbSNP
rs972622874 2071 dbSNP
rs541301895 2088 dbSNP
rs35964492 2093 dbSNP
rs962627155 2101 dbSNP
rs1293983518 2102 dbSNP
rs1399523201 2105 dbSNP
rs924487036 2117 dbSNP
rs1045712364 2121 dbSNP
rs1320558327 2123 dbSNP
rs1420349393 2123 dbSNP
rs949362070 2131 dbSNP
rs917934010 2141 dbSNP
rs1389048078 2144 dbSNP
rs1390473456 2145 dbSNP
rs1163297603 2147 dbSNP
rs1335576216 2157 dbSNP
rs577316423 2160 dbSNP
rs565240251 2162 dbSNP
rs13262354 2168 dbSNP
rs535554707 2171 dbSNP
rs754871055 2173 dbSNP
rs150704756 2174 dbSNP
rs201782330 2179 dbSNP
rs16904998 2200 dbSNP
rs1474805637 2202 dbSNP
rs1239959620 2204 dbSNP
rs74627895 2205 dbSNP
rs998315371 2212 dbSNP
rs1267740000 2213 dbSNP
rs1438877414 2217 dbSNP
rs1447302706 2224 dbSNP
rs902507211 2228 dbSNP
rs1272304939 2240 dbSNP
rs1164098887 2256 dbSNP
rs1042433623 2260 dbSNP
rs779510213 2265 dbSNP
rs1336821623 2275 dbSNP
rs1273792548 2278 dbSNP
rs1294650166 2281 dbSNP
rs1011148265 2286 dbSNP
rs1444993029 2287 dbSNP
rs1008474704 2299 dbSNP
rs753174077 2300 dbSNP
rs1378641588 2302 dbSNP
rs1240440985 2311 dbSNP
rs955026342 2313 dbSNP
rs894032050 2316 dbSNP
rs1223613426 2317 dbSNP
rs1265937261 2328 dbSNP
rs757732302 2332 dbSNP
rs1196511859 2334 dbSNP
rs938140777 2340 dbSNP
rs754317176 2347 dbSNP
rs892836407 2349 dbSNP
rs1181526085 2358 dbSNP
rs1054218314 2359 dbSNP
rs1165618092 2361 dbSNP
rs1423540151 2367 dbSNP
rs566433212 2369 dbSNP
rs1401490295 2371 dbSNP
rs541520454 2371 dbSNP
rs998679182 2373 dbSNP
rs1301921143 2375 dbSNP
rs1330806357 2379 dbSNP
rs1376581259 2388 dbSNP
rs551221938 2391 dbSNP
rs1443631589 2392 dbSNP
rs1395789264 2393 dbSNP
rs866736306 2401 dbSNP
rs781686112 2403 dbSNP
rs532782318 2412 dbSNP
rs755308052 2414 dbSNP
rs949976351 2419 dbSNP
rs1458061152 2422 dbSNP
rs1209218349 2423 dbSNP
rs4734269 2425 dbSNP
rs1484400552 2426 dbSNP
rs1182511381 2432 dbSNP
rs1262589446 2437 dbSNP
rs550680352 2439 dbSNP
rs1416784515 2441 dbSNP
rs938029677 2449 dbSNP
rs1414240093 2450 dbSNP
rs985401981 2455 dbSNP
rs1475536781 2456 dbSNP
rs752977158 2465 dbSNP
rs767705192 2466 dbSNP
rs1252037848 2478 dbSNP
rs998656517 2479 dbSNP
rs1191497474 2480 dbSNP
rs966810776 2483 dbSNP
rs766571308 2486 dbSNP
rs1279990320 2487 dbSNP
rs528967363 2490 dbSNP
rs961524012 2493 dbSNP
rs554745205 2494 dbSNP
rs1211097355 2495 dbSNP
rs536884739 2496 dbSNP
rs1487362717 2513 dbSNP
rs1196000260 2521 dbSNP
rs115028948 2531 dbSNP
rs1478020741 2532 dbSNP
rs1189783146 2533 dbSNP
rs893816581 2542 dbSNP
rs1275197769 2545 dbSNP
rs1055352716 2550 dbSNP
rs181290934 2551 dbSNP
rs996889706 2556 dbSNP
rs957090102 2559 dbSNP
rs73692470 2561 dbSNP
rs1299568163 2571 dbSNP
rs1236895199 2584 dbSNP
rs1435697053 2586 dbSNP
rs998644907 2590 dbSNP
rs1372182935 2591 dbSNP
rs1369507191 2592 dbSNP
rs1235239352 2604 dbSNP
rs1285555812 2607 dbSNP
rs1351835517 2621 dbSNP
rs1218884946 2634 dbSNP
rs906691471 2635 dbSNP
rs1285060291 2640 dbSNP
rs1331192583 2644 dbSNP
rs554046956 2649 dbSNP
rs1046583984 2657 dbSNP
rs903011760 2669 dbSNP
rs146095928 2670 dbSNP
rs1330279272 2671 dbSNP
rs1379294912 2673 dbSNP
rs1410094905 2684 dbSNP
rs1437494935 2690 dbSNP
rs1394055264 2694 dbSNP
rs1171397298 2698 dbSNP
rs546490717 2710 dbSNP
rs1404659617 2714 dbSNP
rs1321534737 2717 dbSNP
rs1351596497 2725 dbSNP
rs1441327963 2736 dbSNP
rs73301557 2749 dbSNP
rs1374938021 2758 dbSNP
rs571597090 2759 dbSNP
rs1242592242 2767 dbSNP
rs1176467888 2769 dbSNP
rs1280169767 2771 dbSNP
rs1036741985 2776 dbSNP
rs1479598896 2778 dbSNP
rs1355756652 2780 dbSNP
rs772137536 2800 dbSNP
rs1208183509 2803 dbSNP
rs1234579359 2805 dbSNP
rs1469356177 2810 dbSNP
rs1198392012 2813 dbSNP
rs1205247119 2825 dbSNP
rs1456128132 2838 dbSNP
rs1180161256 2839 dbSNP
rs940995763 2843 dbSNP
rs1363825194 2850 dbSNP
rs1472166169 2859 dbSNP
rs1160994143 2865 dbSNP
rs1415867237 2869 dbSNP
rs909585159 2873 dbSNP
rs1485401190 2876 dbSNP
rs1461950990 2877 dbSNP
rs1330348177 2878 dbSNP
rs1278377520 2882 dbSNP
rs1449211007 2886 dbSNP
rs1329762848 2890 dbSNP
rs1340136453 2901 dbSNP
rs1242689498 2902 dbSNP
rs1286082061 2905 dbSNP
rs557061603 2914 dbSNP
rs542349347 2915 dbSNP
rs1213305763 2917 dbSNP
rs985778741 2925 dbSNP
rs932606682 2939 dbSNP
rs1196797215 2940 dbSNP
rs922412905 2943 dbSNP
rs976582248 2948 dbSNP
rs1184763234 2952 dbSNP
rs966550186 2960 dbSNP
rs1475471500 2968 dbSNP
rs1169901248 2974 dbSNP
rs750575008 2975 dbSNP
rs1306734198 2977 dbSNP
rs1421450034 2979 dbSNP
rs1466960329 2980 dbSNP
rs1168347283 2984 dbSNP
rs1038412895 2985 dbSNP
rs1021013169 2986 dbSNP
rs1222467474 2993 dbSNP
rs940141196 2999 dbSNP
rs989573611 3001 dbSNP
rs574833253 3008 dbSNP
rs766434499 3009 dbSNP
rs1276836309 3010 dbSNP
rs1342980273 3015 dbSNP
rs958019781 3025 dbSNP
rs1033727824 3026 dbSNP
rs1002850972 3028 dbSNP
rs934190775 3035 dbSNP
rs762811067 3036 dbSNP
rs906814351 3045 dbSNP
rs921504757 3053 dbSNP
rs1442251072 3055 dbSNP
rs765441294 3058 dbSNP
rs1025662033 3087 dbSNP
rs1485700243 3092 dbSNP
rs1192349285 3093 dbSNP
rs1446523193 3098 dbSNP
rs1260926080 3106 dbSNP
rs1374326330 3109 dbSNP
rs1430293031 3131 dbSNP
rs1193558173 3133 dbSNP
rs1376857222 3136 dbSNP
rs1464700943 3138 dbSNP
rs1175786059 3139 dbSNP
rs993604098 3142 dbSNP
rs773134864 3149 dbSNP
rs957260100 3150 dbSNP
rs1436185138 3166 dbSNP
rs1342923964 3169 dbSNP
rs1383284435 3179 dbSNP
rs1032712909 3187 dbSNP
rs188123278 3193 dbSNP
rs977093614 3205 dbSNP
rs1305132126 3207 dbSNP
rs1158074900 3209 dbSNP
rs1215237935 3214 dbSNP
rs1417104066 3217 dbSNP
rs1243928066 3220 dbSNP
rs1410018956 3229 dbSNP
rs1183278097 3232 dbSNP
rs73301556 3236 dbSNP
rs1024078508 3244 dbSNP
rs566297045 3245 dbSNP
rs1431212843 3252 dbSNP
rs139225094 3260 dbSNP
rs941152444 3262 dbSNP
rs1439382022 3269 dbSNP
rs1156869427 3274 dbSNP
rs1459791859 3276 dbSNP
rs1347046982 3287 dbSNP
rs1454715911 3295 dbSNP
rs1486105225 3295 dbSNP
rs888094589 3297 dbSNP
rs1034660589 3301 dbSNP
rs1389254058 3313 dbSNP
rs994802988 3316 dbSNP
rs1371197521 3321 dbSNP
rs1260414723 3330 dbSNP
rs1238978758 3332 dbSNP
rs16904995 3340 dbSNP
rs1318224754 3341 dbSNP
rs932319991 3346 dbSNP
rs1319142813 3356 dbSNP
rs922519571 3361 dbSNP
rs940046291 3368 dbSNP
rs1285488743 3374 dbSNP
rs1487505418 3377 dbSNP
rs1233225274 3379 dbSNP
rs1253410154 3381 dbSNP
rs1457431407 3386 dbSNP
rs1177039068 3389 dbSNP
rs977076323 3391 dbSNP
rs1419714284 3398 dbSNP
rs1164252759 3413 dbSNP
rs1367219031 3417 dbSNP
rs945159013 3430 dbSNP
rs1051153815 3435 dbSNP
rs1326916099 3436 dbSNP
rs913773377 3444 dbSNP
rs1445522536 3482 dbSNP
rs1296074035 3484 dbSNP
rs1416139663 3489 dbSNP
rs1375132970 3491 dbSNP
rs1391462546 3497 dbSNP
rs921482448 3506 dbSNP
rs1319794713 3513 dbSNP
rs976063056 3524 dbSNP
rs1273540099 3527 dbSNP
rs183934729 3532 dbSNP
rs1317047396 3534 dbSNP
rs775304904 3551 dbSNP
rs1481115016 3570 dbSNP
rs926195370 3573 dbSNP
rs958132812 3576 dbSNP
rs1476448824 3580 dbSNP
rs1166310487 3587 dbSNP
rs1423609977 3592 dbSNP
rs1464365664 3595 dbSNP
rs568871308 3601 dbSNP
rs1034084833 3612 dbSNP
rs977061139 3629 dbSNP
rs1159635355 3632 dbSNP
rs1355910629 3636 dbSNP
rs372874716 3637 dbSNP
rs1301682981 3656 dbSNP
rs767422111 3656 dbSNP
rs967048923 3667 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 169200.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aaguaaccugaCGACUACCGGa 5'
                     |:|||||||| 
Target 5' -----------GUUGAUGGCCu 3'
 		1 - 11
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001008495 | 3UTR | AUGGCCUUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001146273 | 3UTR | AUGGCCUUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000458549.2 | 3UTR | GUUGAUGGCCUUGGUGGUGGAAUUUUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
57 hsa-miR-4529-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT226211 TMEM64 transmembrane protein 64 2 2
MIRT241576 LAMC1 laminin subunit gamma 1 2 8
MIRT311423 LMNB1 lamin B1 2 2
MIRT458476 RMI1 RecQ mediated genome instability 1 2 10
MIRT476949 FAM83G family with sequence similarity 83 member G 2 2
MIRT480886 BCL9L B-cell CLL/lymphoma 9 like 2 2
MIRT492825 NXN nucleoredoxin 2 4
MIRT495860 CLCN6 chloride voltage-gated channel 6 2 2
MIRT495919 FBXO41 F-box protein 41 2 2
MIRT497150 PRDM15 PR/SET domain 15 2 2
MIRT498695 LYRM2 LYR motif containing 2 2 4
MIRT499954 ABI2 abl interactor 2 2 2
MIRT501309 RPS21 ribosomal protein S21 2 2
MIRT505941 RAP2C RAP2C, member of RAS oncogene family 2 4
MIRT508422 SFTPB surfactant protein B 2 2
MIRT510705 SREK1IP1 SREK1 interacting protein 1 2 6
MIRT513225 RYK receptor-like tyrosine kinase 2 2
MIRT513775 PER1 period circadian clock 1 2 6
MIRT514948 CD36 CD36 molecule 2 2
MIRT515902 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT516066 RAB42 RAB42, member RAS oncogene family 2 2
MIRT523010 IL6R interleukin 6 receptor 2 2
MIRT525065 FRK fyn related Src family tyrosine kinase 2 2
MIRT530304 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT530445 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT532421 ITFG2 integrin alpha FG-GAP repeat containing 2 2 2
MIRT532626 PHF5A PHD finger protein 5A 2 2
MIRT535128 PLK2 polo like kinase 2 2 2
MIRT539608 SHISA9 shisa family member 9 2 2
MIRT539640 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540213 RAB32 RAB32, member RAS oncogene family 2 2
MIRT540333 OPHN1 oligophrenin 1 2 2
MIRT544350 EGLN1 egl-9 family hypoxia inducible factor 1 2 2
MIRT547521 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT548546 DR1 down-regulator of transcription 1 2 2
MIRT554545 RRN3 RRN3 homolog, RNA polymerase I transcription factor 2 2
MIRT558545 CSNK1A1 casein kinase 1 alpha 1 2 2
MIRT558619 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 4
MIRT563009 U2AF2 U2 small nuclear RNA auxiliary factor 2 2 2
MIRT565148 TUBB2A tubulin beta 2A class IIa 2 2
MIRT567297 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 2
MIRT569071 CADM2 cell adhesion molecule 2 2 2
MIRT570338 VAV3 vav guanine nucleotide exchange factor 3 2 2
MIRT573548 RHOA ras homolog family member A 2 2
MIRT573955 FIGNL1 fidgetin like 1 2 2
MIRT608235 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT610627 SPTA1 spectrin alpha, erythrocytic 1 2 6
MIRT613784 RPS6 ribosomal protein S6 2 2
MIRT620437 CARNS1 carnosine synthase 1 2 2
MIRT629393 CLEC17A C-type lectin domain containing 17A 2 2
MIRT637409 NKX2-3 NK2 homeobox 3 2 2
MIRT659086 DENR density regulated re-initiation and release factor 2 2
MIRT687349 NUP98 nucleoporin 98 2 2
MIRT688532 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT701007 PCSK6 proprotein convertase subtilisin/kexin type 6 2 2
MIRT715878 ACIN1 apoptotic chromatin condensation inducer 1 2 2
MIRT723149 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4529 Tripterygium wilfordii Hook F resistant tissue
hsa-miR-4529-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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