miRTarBase - #MIRT226901


—
pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RAD23B   
Synonyms HHR23B, HR23B, P58
Description RAD23 homolog B, nucleotide excision repair protein
Transcript NM_002874   
Expression
Putative miRNA Targets on RAD23B
3'UTR of RAD23B
(miRNA target sites are highlighted)		 
>RAD23B|NM_002874|3'UTR
   1 AAGGGACTTTTTTATATCTCACACTTCACACCAGTGCATTACACTAACTTGTTCACTGGATTGTCTGGGATGACTTGGGC
  81 TCATATCCACAATACTTGGTATAAGGTAGTAGATTGTTGGGGGTGGGGAGGGAGGGATCTAGGATACAGGGCAGGGATAA
 161 ATACAGTGCATGTCTGCTTCAATTAGCAGATGCCGCAACTCCACACAGTGTGTAAAATATATACAACCAAAAATCAGCTT
 241 TTGCAGGTCTTTATTTCTTCTGTAAAACAGTAGGTAACTTTTCCTAGGTTTCACTCTTTTTAGTGTACTAGATCCAGAAA
 321 CTTAGTGTAATGCCCTGCTTTATATTTCTTTGACTTAACATTGGTTTCAGAAAGAATCTTAGCTACCTAGAATTTACAGT
 401 CTCTGTTTCATGGCAACACTGGATAATGGCTTTGTGAAATTTAAAAAATTTTTGTAGCGACTGTAAACAGAAATGCCAAA
 481 TTGATGGTTAATTGTTGCTGCTTCAAAAATAAGTATAAAATTAATATGTAAGGAAGCCCATTCTTTCATGTTAAATACTT
 561 GGGGTGGGAGGGGAGAAAGGGAACCTTTTCTTAAAATGAAAATAATTACTGCTATTTTAAAATTTCTTGATCATTGAATG
 641 TGAGACCCTTCTAACATGATTTGAGAAGCTGTACAAGTATAGGCAGAGTTATTTTCCTGTTTACATTTTTTTTTTGTTTT
 721 GGGGAAAAAATTGGTAGGTGTCTAATTACTGTTTACTTCATTGTTATATTGCAGTAAAAGTTTTAAAACAACCATTGCAT
 801 GTTTGCTTTTGATGTATCCCTTTGTGAAATTAGCACTTTTGGGGCCAATGGAGAAATGCAGCATTCACTCTCCCTGTCTT
 881 TTCCCCTTCCCTCAGCAGAAACGTGTTTATCAGCAAGTCGTGAGTCAAACTGCTGCCTTTTAAAAAACCCACAAAATGCT
 961 GATTCAGTTCAAAATTAATGCAAATGTTTCAAAACTGGGTTTCTGATATTTGTAAATGTGTTTCTTTATTAGATAAGAGT
1041 GTATTACCATTAAAGTCATTAGTATAATATTGCTTTCAAAAAGAAATGGTAGACAAAACTATAATCCAGCATCTTTTATT
1121 GCATTGGAAAGACTGGCAAAGTCTTTTGGATGGGTTGGGAGATGTGGCTGGAAAGTACTTTGGAAAATATACAATCAAGA
1201 TATCTCATGGCATATTAAAAGAAAAATCTTAATAGCAGTGTTGGCTTTTATTTGGATTTTTTCATCTCAGTTTTTTCTGT
1281 GGAATCTCCTTCATTGGCATTGTTATTTAATCATAAACGGGGCAGATGTCTACTTGTTCAGTTTTTCAAATCTGTTTTCC
1361 TGAGTATAAATAAGAGTATTTAAAGAAATAATTTGGATTGCTTTTGTTTTTTGTTTCCTTTTTTTTAACCATCTGATACT
1441 AAGAAGATGAATTTGCACAGATTTCTCTGCATAATTTCTCAATATCTTTAGCACAGTATGGTGATGATGACTTTTAAGCA
1521 TTTACATCACGTACTCATAACCTATTATGAAAATAAATGAAACTGGCTGGGTATGGTGGCTCATGCCTATAATCCCAGCA
1601 CTTTGGGAGGCCGAGGTGGGCAGATCACTTGAGGCCAGGAGATTGAGACCAGCCTGACCGTCATGGCGAAACCCCGTCTA
1681 TACTAAAAATACAAAAAATAGCCAGGCATGGTGGCGCACGCCTGTGGTCCCAGCTACTTGGGAGGCTGAGGCATGAGAAT
1761 TGCTTGAACCCGGGAAGTGAAGGTTGCCGTGAGCTGAGATCACACCACTGCCATAAACATGACAGGCTTTTGGACTTTGT
1841 ATTACCTGTATGTTTTATAATGGATCATGCATAATTTCTCAGGAGAATAAAATGAGAATTCATATATACGTTCATCTTTC
1921 AAGTCAGAGCAATGAGTTGGGAAAAGAGGTGGCATTTCTGATCGGATAATGGAATACTCTCATTTATTTTATGACATTCT
2001 CTGTCTACTCAGATCATAGTGAAAACTGGAAACAAAAAAAAAAAACAGCCTCTTCTTGGAAAGTGACAGCAGAAGGTGGC
2081 ATGGAGCTTGTGTCCTTGGACAACAAATCTGGATATACTAGGATTAATTATCAGAAGACAGCTCAGGCCAAGTTTTGATC
2161 GTTCCATACAGTACCTTGTTTATCTGCTTCTTAAAGAATCAGCCGAGACACCATAAAAGAAATAGGCTTTTTGTGCCTTT
2241 TGCTGTTAATGTTTAATTTACAAACTGTTTTGGTAAATCTCTTAATGTAAGTAGCTATTTGACTTTGGAATTTTGCATTC
2321 GAGGTATACTGTCATTTCTTGAAATCTTTTTCTCGTTTAGTTGCTCTGTGGGAAATGTGAGGAAGCCTAAGTTTGTATTT
2401 GTAAATTTCTTATGCCATCCTCTAGTCAAATTTTTTTTCATTGTTTAAAAATACGGAAGTGTTCCAATATAATTTTTTCC
2481 TGTACTGGATGGCTAGGATTCTAGAGAATTGATTATAAAATATTTTCAATACATCCAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauCGGAGGU---ACUU-AAGACUAc 5'
             |::|| |   ||:: ||||||| 
Target 5' aatGTTTCAAAACTGGGTTTCTGATa 3'
 983 - 1008 151.00 -9.40
2 
miRNA  3' gaUCGGAGGUACUUAAGACUAc 5'
            || :  |||   ||||||| 
Target 5' agAGGTGGCAT---TTCTGATc 3'
 1945 - 1963 145.00 -7.60
3 
miRNA  3' gaUCGGAGGUAC---UUAAGACUAc 5'
            |||  :|| |   |:||:|||| 
Target 5' acAGC--TCAGGCCAAGTTTTGATc 3'
 2138 - 2160 136.00 -9.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30141773 13 COSMIC
COSN30521701 35 COSMIC
COSN9275043 38 COSMIC
COSN30183016 68 COSMIC
COSN30662624 80 COSMIC
COSN31577893 108 COSMIC
COSN8519771 166 COSMIC
COSN26558286 173 COSMIC
COSN30176132 272 COSMIC
COSN31538441 460 COSMIC
COSN31579782 641 COSMIC
COSN26537613 643 COSMIC
COSN31583889 716 COSMIC
COSN28733393 722 COSMIC
COSN31542725 750 COSMIC
COSN31549977 841 COSMIC
COSN26641448 890 COSMIC
COSN31513134 948 COSMIC
COSN31526393 1068 COSMIC
COSN31579609 1087 COSMIC
COSN31485663 1099 COSMIC
COSN15661716 1111 COSMIC
COSN31528022 1188 COSMIC
COSN31556273 1263 COSMIC
COSN31608317 1386 COSMIC
COSN25425936 1420 COSMIC
COSN20106442 1427 COSMIC
COSN30541509 1427 COSMIC
COSN9694288 1497 COSMIC
COSN31534536 1886 COSMIC
COSN31529254 1891 COSMIC
COSN30134466 1903 COSMIC
COSN16591005 1980 COSMIC
COSM8972075 2011 COSMIC
COSN19664837 2034 COSMIC
COSN9974986 2034 COSMIC
COSN19749803 2035 COSMIC
COSM1732823 2045 COSMIC
COSM5416847 2046 COSMIC
COSM5445927 2046 COSMIC
COSM5713176 2046 COSMIC
COSN31496306 2073 COSMIC
COSN26991408 2075 COSMIC
COSN30148314 2112 COSMIC
COSN30108617 2173 COSMIC
COSN5117830 2199 COSMIC
COSN31525795 2220 COSMIC
COSN1371488 2261 COSMIC
COSN8117120 2274 COSMIC
COSN27154663 2495 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1381301115 8 dbSNP
rs768564593 8 dbSNP
rs766346381 10 dbSNP
rs1206271713 12 dbSNP
rs775546389 13 dbSNP
rs539177608 15 dbSNP
rs1196232325 17 dbSNP
rs1412413464 20 dbSNP
rs764249052 20 dbSNP
rs557717473 25 dbSNP
rs988006756 26 dbSNP
rs374812476 32 dbSNP
rs774320789 34 dbSNP
rs1368606900 35 dbSNP
rs1041102111 37 dbSNP
rs1431624283 37 dbSNP
rs1308398201 39 dbSNP
rs1389675266 43 dbSNP
rs921231983 44 dbSNP
rs1384866383 45 dbSNP
rs765716880 47 dbSNP
rs932544394 55 dbSNP
rs1428115561 58 dbSNP
rs1257150796 75 dbSNP
rs1048312158 76 dbSNP
rs970368733 79 dbSNP
rs1484734561 80 dbSNP
rs527390012 84 dbSNP
rs1257360335 89 dbSNP
rs745960194 91 dbSNP
rs888298480 93 dbSNP
rs940854316 99 dbSNP
rs1171028493 119 dbSNP
rs769862103 123 dbSNP
rs1390927951 125 dbSNP
rs1294784531 126 dbSNP
rs1429161568 130 dbSNP
rs1415032596 134 dbSNP
rs1230857616 135 dbSNP
rs1354250009 143 dbSNP
rs1037125838 145 dbSNP
rs1174280227 154 dbSNP
rs1411549252 160 dbSNP
rs1370038202 161 dbSNP
rs1297342725 169 dbSNP
rs1369204143 171 dbSNP
rs1167388961 172 dbSNP
rs556522624 174 dbSNP
rs569694831 177 dbSNP
rs941771400 179 dbSNP
rs973620168 182 dbSNP
rs375450940 183 dbSNP
rs929430449 189 dbSNP
rs1421377517 191 dbSNP
rs1249065458 194 dbSNP
rs868382717 195 dbSNP
rs1052037042 196 dbSNP
rs890673571 198 dbSNP
rs1274604881 199 dbSNP
rs775605756 204 dbSNP
rs1310058669 207 dbSNP
rs1211428091 209 dbSNP
rs1336616524 213 dbSNP
rs1039439428 216 dbSNP
rs1240586242 221 dbSNP
rs895426331 224 dbSNP
rs1011590589 227 dbSNP
rs1022480895 228 dbSNP
rs1392601085 234 dbSNP
rs966855444 239 dbSNP
rs978199500 239 dbSNP
rs537735798 246 dbSNP
rs1159926157 247 dbSNP
rs1273499204 248 dbSNP
rs1362522131 254 dbSNP
rs904646891 258 dbSNP
rs1000672289 271 dbSNP
rs965498675 287 dbSNP
rs551940208 289 dbSNP
rs1192219307 296 dbSNP
rs796324218 297 dbSNP
rs1032165722 304 dbSNP
rs1206344644 314 dbSNP
rs892315700 317 dbSNP
rs1009313655 327 dbSNP
rs932310723 328 dbSNP
rs984040352 330 dbSNP
rs1024853463 339 dbSNP
rs574394172 343 dbSNP
rs1206743375 344 dbSNP
rs1439909380 344 dbSNP
rs777214851 355 dbSNP
rs909765873 361 dbSNP
rs1402468677 362 dbSNP
rs1382847632 381 dbSNP
rs749565496 399 dbSNP
rs980500514 402 dbSNP
rs1397447521 404 dbSNP
rs541566032 411 dbSNP
rs963187401 416 dbSNP
rs1454133272 419 dbSNP
rs1248208989 420 dbSNP
rs939417368 422 dbSNP
rs553311979 423 dbSNP
rs895157598 424 dbSNP
rs1010826220 425 dbSNP
rs1349891056 438 dbSNP
rs1278101350 442 dbSNP
rs75991696 449 dbSNP
rs918986071 451 dbSNP
rs929463209 454 dbSNP
rs577829744 456 dbSNP
rs578037025 458 dbSNP
rs987604448 460 dbSNP
rs764158621 469 dbSNP
rs1324968944 477 dbSNP
rs191366645 480 dbSNP
rs546191875 495 dbSNP
rs1415484056 507 dbSNP
rs1377757461 514 dbSNP
rs1404998922 516 dbSNP
rs563340179 522 dbSNP
rs1321913135 524 dbSNP
rs1434696073 532 dbSNP
rs530855401 533 dbSNP
rs1391138198 535 dbSNP
rs1170074355 539 dbSNP
rs999688461 541 dbSNP
rs1442219230 545 dbSNP
rs1297482688 549 dbSNP
rs768739360 553 dbSNP
rs564279965 562 dbSNP
rs1363696022 563 dbSNP
rs181346324 564 dbSNP
rs1210041175 569 dbSNP
rs1251445764 584 dbSNP
rs1355141634 586 dbSNP
rs144519721 594 dbSNP
rs1212606254 603 dbSNP
rs1039060711 605 dbSNP
rs1337623561 610 dbSNP
rs976926355 615 dbSNP
rs1028032526 622 dbSNP
rs904511515 627 dbSNP
rs1357425760 629 dbSNP
rs953852517 633 dbSNP
rs760544405 635 dbSNP
rs1414703489 648 dbSNP
rs1291712874 649 dbSNP
rs1355687871 660 dbSNP
rs766426196 669 dbSNP
rs1331226032 676 dbSNP
rs1408575425 678 dbSNP
rs983779362 681 dbSNP
rs1165220235 685 dbSNP
rs1053133557 690 dbSNP
rs529199058 692 dbSNP
rs1414976143 701 dbSNP
rs372624525 706 dbSNP
rs909837876 706 dbSNP
rs79068921 707 dbSNP
rs11548919 717 dbSNP
rs1451313406 721 dbSNP
rs1195344023 722 dbSNP
rs939897708 725 dbSNP
rs972588320 725 dbSNP
rs1337310261 726 dbSNP
rs891844308 739 dbSNP
rs576790854 740 dbSNP
rs927798622 743 dbSNP
rs547537939 751 dbSNP
rs1440406589 755 dbSNP
rs765640027 758 dbSNP
rs1327037943 760 dbSNP
rs565767613 761 dbSNP
rs533022810 772 dbSNP
rs906473374 775 dbSNP
rs1391860040 818 dbSNP
rs1002516776 834 dbSNP
rs528741804 837 dbSNP
rs137879048 849 dbSNP
rs916639237 850 dbSNP
rs1175393051 853 dbSNP
rs1469601428 860 dbSNP
rs142311785 867 dbSNP
rs1195331991 868 dbSNP
rs1469943296 870 dbSNP
rs963392849 871 dbSNP
rs1317614669 872 dbSNP
rs867438100 874 dbSNP
rs537003734 879 dbSNP
rs1043705570 894 dbSNP
rs1437922970 896 dbSNP
rs549001234 902 dbSNP
rs567930659 903 dbSNP
rs1040602002 904 dbSNP
rs1803720 905 dbSNP
rs535023446 906 dbSNP
rs1324832759 908 dbSNP
rs10868 920 dbSNP
rs145941436 922 dbSNP
rs1803721 928 dbSNP
rs1028525318 931 dbSNP
rs1395625013 943 dbSNP
rs11573725 953 dbSNP
rs34286293 961 dbSNP
rs1251318868 973 dbSNP
rs186771546 980 dbSNP
rs372403280 984 dbSNP
rs1243912284 990 dbSNP
rs975415669 993 dbSNP
rs961001651 999 dbSNP
rs1266019750 1005 dbSNP
rs1466145366 1021 dbSNP
rs55713214 1021 dbSNP
rs1205676829 1023 dbSNP
rs1262457676 1038 dbSNP
rs1236892083 1039 dbSNP
rs1346145811 1048 dbSNP
rs1303184561 1050 dbSNP
rs1214795025 1057 dbSNP
rs926204589 1061 dbSNP
rs1363710943 1062 dbSNP
rs758994948 1063 dbSNP
rs936006201 1065 dbSNP
rs1441894586 1071 dbSNP
rs1053038644 1073 dbSNP
rs1375948123 1079 dbSNP
rs1314671197 1084 dbSNP
rs1432836506 1089 dbSNP
rs913356457 1092 dbSNP
rs1394215728 1094 dbSNP
rs1170963438 1096 dbSNP
rs1185564272 1099 dbSNP
rs973080707 1101 dbSNP
rs1184820768 1102 dbSNP
rs1488018263 1103 dbSNP
rs950117055 1103 dbSNP
rs1258382666 1110 dbSNP
rs927864947 1112 dbSNP
rs960832799 1114 dbSNP
rs990663383 1117 dbSNP
rs575340241 1120 dbSNP
rs538963557 1144 dbSNP
rs542586304 1144 dbSNP
rs1293035854 1147 dbSNP
rs906370772 1148 dbSNP
rs1410224047 1151 dbSNP
rs1294637078 1155 dbSNP
rs1043737252 1165 dbSNP
rs886206951 1173 dbSNP
rs1374832516 1175 dbSNP
rs560965805 1191 dbSNP
rs1289995605 1195 dbSNP
rs1168577039 1196 dbSNP
rs1477643151 1197 dbSNP
rs1418661431 1199 dbSNP
rs1402185215 1201 dbSNP
rs1190227337 1202 dbSNP
rs1393783655 1212 dbSNP
rs1335683553 1225 dbSNP
rs1055454325 1226 dbSNP
rs935294149 1226 dbSNP
rs573866812 1229 dbSNP
rs113606634 1239 dbSNP
rs540992998 1258 dbSNP
rs1250025569 1265 dbSNP
rs1197582767 1271 dbSNP
rs996787184 1272 dbSNP
rs1274488029 1273 dbSNP
rs1230933736 1281 dbSNP
rs1025983681 1283 dbSNP
rs1286179829 1285 dbSNP
rs1354701059 1289 dbSNP
rs950471578 1294 dbSNP
rs1307649483 1300 dbSNP
rs1393118774 1301 dbSNP
rs1370872694 1314 dbSNP
rs1297461398 1315 dbSNP
rs139958204 1319 dbSNP
rs1018669596 1320 dbSNP
rs1255308898 1322 dbSNP
rs889566670 1323 dbSNP
rs533017943 1326 dbSNP
rs190526583 1330 dbSNP
rs1183135354 1331 dbSNP
rs1421438832 1337 dbSNP
rs1248852956 1341 dbSNP
rs1178470595 1343 dbSNP
rs1380775370 1350 dbSNP
rs1468595209 1351 dbSNP
rs1274663972 1354 dbSNP
rs1259718765 1367 dbSNP
rs926230050 1368 dbSNP
rs1211228424 1369 dbSNP
rs1355016355 1371 dbSNP
rs1486084730 1371 dbSNP
rs957640300 1377 dbSNP
rs988794288 1383 dbSNP
rs11573726 1395 dbSNP
rs752123337 1398 dbSNP
rs1045811929 1400 dbSNP
rs1371950219 1401 dbSNP
rs1328199218 1408 dbSNP
rs1159287833 1419 dbSNP
rs199795066 1419 dbSNP
rs76865619 1419 dbSNP
rs796917575 1419 dbSNP
rs11573727 1420 dbSNP
rs1455789553 1424 dbSNP
rs1362580403 1425 dbSNP
rs386519878 1427 dbSNP
rs927360886 1432 dbSNP
rs937850243 1434 dbSNP
rs916401923 1436 dbSNP
rs967827451 1437 dbSNP
rs537000345 1441 dbSNP
rs923992852 1446 dbSNP
rs1206393581 1450 dbSNP
rs1484815412 1452 dbSNP
rs1464993598 1457 dbSNP
rs1285264259 1460 dbSNP
rs536694596 1466 dbSNP
rs935367855 1472 dbSNP
rs758125141 1483 dbSNP
rs976106518 1485 dbSNP
rs1231331029 1500 dbSNP
rs763729909 1502 dbSNP
rs923542325 1508 dbSNP
rs11573728 1510 dbSNP
rs1383998533 1515 dbSNP
rs548964336 1528 dbSNP
rs567178774 1531 dbSNP
rs1008547301 1532 dbSNP
rs942136307 1535 dbSNP
rs1172230475 1537 dbSNP
rs1477458535 1550 dbSNP
rs1019114744 1555 dbSNP
rs1038135665 1563 dbSNP
rs896901589 1564 dbSNP
rs751923971 1567 dbSNP
rs1391756513 1568 dbSNP
rs1300403215 1570 dbSNP
rs994281028 1572 dbSNP
rs11573729 1583 dbSNP
rs896423370 1584 dbSNP
rs11573730 1587 dbSNP
rs1344494884 1590 dbSNP
rs571919292 1597 dbSNP
rs1282518227 1605 dbSNP
rs1338484679 1608 dbSNP
rs1277724118 1611 dbSNP
rs538811643 1613 dbSNP
rs1204590535 1614 dbSNP
rs1272721010 1617 dbSNP
rs1481772510 1619 dbSNP
rs369782438 1621 dbSNP
rs957646031 1627 dbSNP
rs1396711880 1628 dbSNP
rs1169261501 1629 dbSNP
rs989034641 1634 dbSNP
rs757559482 1637 dbSNP
rs11573731 1644 dbSNP
rs979226217 1645 dbSNP
rs1031084192 1649 dbSNP
rs981432258 1656 dbSNP
rs976516101 1660 dbSNP
rs927404682 1661 dbSNP
rs923308472 1664 dbSNP
rs937439147 1668 dbSNP
rs11573732 1669 dbSNP
rs139160927 1673 dbSNP
rs1282968475 1674 dbSNP
rs369089784 1676 dbSNP
rs566703990 1677 dbSNP
rs1331372553 1679 dbSNP
rs751661857 1684 dbSNP
rs1047696909 1693 dbSNP
rs1036532408 1694 dbSNP
rs1411468723 1698 dbSNP
rs1162557258 1700 dbSNP
rs1304023981 1704 dbSNP
rs896934059 1707 dbSNP
rs886320247 1708 dbSNP
rs929728949 1716 dbSNP
rs944385732 1717 dbSNP
rs1227764682 1720 dbSNP
rs371384181 1721 dbSNP
rs1040034732 1723 dbSNP
rs1309429137 1724 dbSNP
rs1214349036 1727 dbSNP
rs1337013833 1728 dbSNP
rs780231682 1729 dbSNP
rs749317451 1737 dbSNP
rs1228245486 1748 dbSNP
rs554519078 1756 dbSNP
rs573200907 1761 dbSNP
rs1265188833 1766 dbSNP
rs995924236 1772 dbSNP
rs1033145225 1773 dbSNP
rs1012287968 1787 dbSNP
rs893323059 1788 dbSNP
rs1010320941 1789 dbSNP
rs758097006 1799 dbSNP
rs1023540882 1801 dbSNP
rs1410079405 1802 dbSNP
rs1020500905 1803 dbSNP
rs1156570083 1804 dbSNP
rs903776461 1805 dbSNP
rs971614265 1808 dbSNP
rs1194473426 1812 dbSNP
rs1000678141 1823 dbSNP
rs1030778994 1824 dbSNP
rs541306483 1839 dbSNP
rs559343109 1842 dbSNP
rs1428690176 1847 dbSNP
rs1163671131 1862 dbSNP
rs981889214 1864 dbSNP
rs149796946 1868 dbSNP
rs1238363069 1870 dbSNP
rs769068900 1872 dbSNP
rs953412385 1875 dbSNP
rs986123719 1879 dbSNP
rs1236028817 1883 dbSNP
rs1365073636 1888 dbSNP
rs550734856 1897 dbSNP
rs1292373009 1906 dbSNP
rs974199329 1910 dbSNP
rs779212449 1911 dbSNP
rs545194250 1914 dbSNP
rs746816567 1923 dbSNP
rs963606638 1926 dbSNP
rs563487992 1927 dbSNP
rs563214216 1933 dbSNP
rs1387736338 1934 dbSNP
rs919447112 1950 dbSNP
rs770804710 1954 dbSNP
rs1268445531 1959 dbSNP
rs1364212930 1963 dbSNP
rs776531519 1964 dbSNP
rs759563283 1965 dbSNP
rs1295545453 1966 dbSNP
rs747355521 1974 dbSNP
rs534320407 1977 dbSNP
rs754617487 1978 dbSNP
rs549146278 1980 dbSNP
rs767301542 1980 dbSNP
rs750208354 1982 dbSNP
rs759746568 1983 dbSNP
rs747636463 1985 dbSNP
rs769489666 1986 dbSNP
rs1468680679 1987 dbSNP
rs765383663 1990 dbSNP
rs1387848404 1995 dbSNP
rs1173009387 1998 dbSNP
rs752821921 1998 dbSNP
rs773279590 2000 dbSNP
rs1367853796 2001 dbSNP
rs758612133 2002 dbSNP
rs749281843 2004 dbSNP
rs770829426 2005 dbSNP
rs774152058 2006 dbSNP
rs372631779 2008 dbSNP
rs764315995 2011 dbSNP
rs776771747 2013 dbSNP
rs560930748 2016 dbSNP
rs765338010 2019 dbSNP
rs750906737 2024 dbSNP
rs758853076 2025 dbSNP
rs766825572 2027 dbSNP
rs1266443903 2028 dbSNP
rs1335062018 2029 dbSNP
rs543833699 2030 dbSNP
rs867639615 2030 dbSNP
rs1175594421 2033 dbSNP
rs751885444 2033 dbSNP
rs1255813806 2034 dbSNP
rs1482468848 2034 dbSNP
rs1491274466 2034 dbSNP
rs201461138 2034 dbSNP
rs3056494 2034 dbSNP
rs539541320 2034 dbSNP
rs556046245 2034 dbSNP
rs560202425 2034 dbSNP
rs5899731 2034 dbSNP
rs74357018 2034 dbSNP
rs746219182 2034 dbSNP
rs569032036 2035 dbSNP
rs767597678 2035 dbSNP
rs1491056535 2036 dbSNP
rs780887003 2037 dbSNP
rs747878482 2038 dbSNP
rs755658013 2041 dbSNP
rs768193911 2042 dbSNP
rs1255536909 2044 dbSNP
rs398068862 2044 dbSNP
rs1040471173 2045 dbSNP
rs554518485 2046 dbSNP
rs76190394 2046 dbSNP
rs1346240619 2047 dbSNP
rs748833744 2049 dbSNP
rs760455028 2051 dbSNP
rs1054213513 2052 dbSNP
rs1157127438 2053 dbSNP
rs1298599723 2055 dbSNP
rs868177885 2056 dbSNP
rs1435842113 2064 dbSNP
rs892853548 2069 dbSNP
rs1302382455 2078 dbSNP
rs770865471 2080 dbSNP
rs1347494271 2081 dbSNP
rs1398366972 2082 dbSNP
rs774165127 2088 dbSNP
rs1010394448 2089 dbSNP
rs1402742172 2092 dbSNP
rs546579904 2096 dbSNP
rs1465191568 2097 dbSNP
rs1226977045 2103 dbSNP
rs771825913 2104 dbSNP
rs776877688 2105 dbSNP
rs1418727510 2107 dbSNP
rs765486139 2112 dbSNP
rs371086485 2124 dbSNP
rs1249155173 2131 dbSNP
rs374441589 2132 dbSNP
rs953586062 2141 dbSNP
rs1007590926 2142 dbSNP
rs1236013338 2146 dbSNP
rs1003114361 2150 dbSNP
rs374669894 2151 dbSNP
rs1034987554 2161 dbSNP
rs958753049 2162 dbSNP
rs919464500 2169 dbSNP
rs1321107110 2171 dbSNP
rs1448967267 2174 dbSNP
rs769602263 2175 dbSNP
rs1392955735 2176 dbSNP
rs1027081264 2179 dbSNP
rs917697537 2190 dbSNP
rs1222461699 2196 dbSNP
rs550749115 2197 dbSNP
rs1295424299 2199 dbSNP
rs951437210 2201 dbSNP
rs947793678 2203 dbSNP
rs112298213 2205 dbSNP
rs1441954996 2206 dbSNP
rs536340565 2206 dbSNP
rs1208805672 2210 dbSNP
rs763748378 2211 dbSNP
rs1052369575 2216 dbSNP
rs1235261890 2224 dbSNP
rs1486422465 2225 dbSNP
rs1488096149 2229 dbSNP
rs1261264668 2231 dbSNP
rs1188259619 2234 dbSNP
rs1351199616 2242 dbSNP
rs183028018 2243 dbSNP
rs1308351922 2244 dbSNP
rs966241553 2248 dbSNP
rs751163030 2250 dbSNP
rs554804197 2255 dbSNP
rs976042318 2264 dbSNP
rs1390581087 2266 dbSNP
rs566963270 2268 dbSNP
rs1422105118 2269 dbSNP
rs1471476309 2274 dbSNP
rs1359019498 2275 dbSNP
rs1052016458 2298 dbSNP
rs745917776 2304 dbSNP
rs889237952 2310 dbSNP
rs533418264 2317 dbSNP
rs1196072002 2318 dbSNP
rs1432068921 2321 dbSNP
rs1261873300 2322 dbSNP
rs1218705699 2325 dbSNP
rs1487302886 2327 dbSNP
rs1284975423 2329 dbSNP
rs1413844453 2332 dbSNP
rs558930722 2336 dbSNP
rs1345924888 2344 dbSNP
rs1427539507 2355 dbSNP
rs762197184 2356 dbSNP
rs1231395321 2359 dbSNP
rs1278989489 2367 dbSNP
rs1402381605 2369 dbSNP
rs1007661210 2373 dbSNP
rs1297931011 2375 dbSNP
rs931673970 2385 dbSNP
rs1404866163 2386 dbSNP
rs1373731530 2390 dbSNP
rs1416810023 2394 dbSNP
rs1313678713 2396 dbSNP
rs1195234033 2400 dbSNP
rs1476763570 2410 dbSNP
rs763891135 2414 dbSNP
rs1054041781 2417 dbSNP
rs577825450 2425 dbSNP
rs1276287327 2428 dbSNP
rs14705 2431 dbSNP
rs1281703838 2445 dbSNP
rs1258726861 2448 dbSNP
rs960549332 2455 dbSNP
rs545356163 2456 dbSNP
rs1342636219 2457 dbSNP
rs187746386 2457 dbSNP
rs1332677449 2469 dbSNP
rs1277524532 2472 dbSNP
rs1395033852 2480 dbSNP
rs1400583952 2486 dbSNP
rs73517777 2487 dbSNP
rs538027046 2489 dbSNP
rs1463624096 2490 dbSNP
rs980488986 2493 dbSNP
rs1211043606 2495 dbSNP
rs1165517908 2505 dbSNP
rs1473774702 2507 dbSNP
rs1003430966 2510 dbSNP
rs936373630 2512 dbSNP
rs1056055254 2515 dbSNP
rs1441990577 2530 dbSNP
rs1183633930 2532 dbSNP
rs780422825 2533 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 5887.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gauCGGAGGU---ACUU-AAGACUAc 5'
             |::|| |   ||:: ||||||| 
Target 5' ---GUUUCAAAACUGGGUUUCUGAUa 3'
 		1 - 23
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000358015.3 | 3UTR | GUUUCAAAACUGGGUUUCUGAUAUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC -0.889 0.15 -1.000 0.5 3 Click to see details
BRCA 0.188 0.16 0.106 0.29 31 Click to see details
BLCA 0.295 0.29 0.314 0.27 6 Click to see details
HNSC -0.161 0.29 -0.011 0.49 14 Click to see details
STAD 0.606 0.29 0.500 0.33 3 Click to see details
LIHC 0.396 0.3 0.400 0.3 4 Click to see details
LUSC -0.057 0.42 0.096 0.37 15 Click to see details
LUSC -0.057 0.42 0.096 0.37 15 Click to see details
LUSC -0.057 0.42 0.096 0.37 15 Click to see details
LUSC -0.057 0.42 0.096 0.37 15 Click to see details
LUSC -0.057 0.42 0.096 0.37 15 Click to see details
LUSC -0.057 0.42 0.096 0.37 15 Click to see details
LUSC -0.057 0.42 0.096 0.37 15 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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