miRTarBase - #MIRT226972


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pre-miRNA Information
pre-miRNA hsa-mir-511   
Genomic Coordinates chr10: 17845107 - 17845193
Description Homo sapiens miR-511 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-511-3p
Sequence 54| AAUGUGUAGCAAAAGACAGA |73
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30502461 14 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs548691953 3 dbSNP
rs1322530388 4 dbSNP
rs1313209508 11 dbSNP
rs1223031412 19 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol AKAP2   
Synonyms AKAP-2, AKAPKL, MISP2, PRKA2
Description A-kinase anchoring protein 2
Transcript NM_001004065   
Other Transcripts NM_001136562   
Expression
Putative miRNA Targets on AKAP2
3'UTR of AKAP2
(miRNA target sites are highlighted)		 
>AKAP2|NM_001004065|3'UTR
   1 ACTTCCTTCAACCCAGGAAGCGTCTTTGGTGCTTGGGAGACCAAGAAACCAAGAAATTAACAACTGAAAGCATTTTAATG
  81 GACTATTTATTAAAGTGCAAACAAACTCAGCAATCCTTATGTAGACCAGAAGCTGCAATATACAATGATGAAAATGAAAC
 161 GAAAAGGAAGTCCCCCCATCAGACTCTGGACACCCAGGAATCAAAAGAGAAAGGACTTTTTTGGTGACTCAATCCCAGTG
 241 TCTGGTTTGGGGCCAATCTACAATGGATCCAAAAGGACAAAACATGTTACAAGCAAATCAACATAGTTGCTGCAGGCGGA
 321 ACTGAGACCAGCCTCTCTGGGCGATGAAGGACAATGGTGGTAGGGCCACTTAGAGAGCAGTAGGGCCCAGGCTGGTGCAG
 401 CCTACATGGCACAGGATATTTCCCTGCACCAGTTTCCCACCTGTCACTTGCAGCATCAGAGGGTGTTGCATTAACTCCAT
 481 TTTCTCCAGCAGCCATAAAATGAATGGCGTTTCTCTCCATATTTGCCCAGAAGAGGCAGTTATGATTCCACTTCTCCTAC
 561 ATTTAATTATTTTTAATTGAGAACAACTCATGATCACAATTCATAAAATCCATATTTTAAGACAATAGTTCTTCATGTCA
 641 CAAACACAATCTATTCTACATGAGGAGGCTGAGAAAGGGGAAGAGAAAAACAAACCAAATGGATGATGTTAGCTTTAGGA
 721 TCGTGTCTGCTTATAATATTCACTGATCTGCAGTTTATGAGAACACATTTTCACAGTTATGTTTCTTCATAGGAAAACTA
 801 TATTTAGTGGGCAACAACTATTTTTATGATGGGATGGGGGAGTATATACACGTATAGAATCTGTACGCGTTGAACAACTT
 881 GGTTCAAGATGGTGGGGGCATTTTTAGAGCGGCAATAATTGAAAAAAAAGGCGAACTCTGCCTTGGAGAGGTAGATGATA
 961 AGAAATAAAAAGGTGTTTATAACTATTTTGTATTATAAAGTGGGCCTTAGAGATAGGAAGAAGAATGATGGATTCCTTTT
1041 GGATCAATCAGAAAGGAAACACGAAAGAAAAGTCAGGAAGGTAGAGAGAGAAAAAGGGAGGGAAGGAGAAAGAATGGGAA
1121 TAAAATAAGGAGGTAAGAGATACTATTTTTGCTGAGCAACCAGTGTGTTTCAGGATGATACAAAGAAAAATATAGAATAG
1201 AAATAAGTGCAGGCTTGGAATCAGCTACAAATCCTAAAGATGGGGTGTGTGTGGATGTGTGTGTGTGTGTGTGTACACCA
1281 TTGTGTGTTTGTAAAATGTGTATGTTCATGAGTAAGGGTGTGTGTGTGTGTGTATTAAAATTCCAGAGTGACCGTGGCAC
1361 TTGGGTGTACAGGTAATTCCTCCAGAGCTGTTTGCTGGCTTCAGGAGTGGAGTGAGAATTTCTTTTTTATGAAAAGGGAT
1441 ATAAAGGCACCGAGCTGATGCAGTATTTGTAATATTAAGTTGACCTAACAAGGTATTTGCATGAGTCACAATTACAAAGT
1521 TTTGAGCGGTTTTGTAATTTGACATTTAGGAGAGTCTCCTATTTATTCTCATACTTTACATTCATGCTTAGTATACTATA
1601 GAGGATGCCAGCTTTAATCTTTCTGTCATTTAAAGCAATATGATAAGGGTATTCAATAATTGGGTGCCCTAAATTTCTGG
1681 ATGAGAAAATTTTCAATTCTGGCCATGAGAAAGAAAAAAAAATAAACAGCCTTCTTTTTTTTTCCTTTGTTTTAAAACTG
1761 TGGTTTTTTAAAAAAGCAATAATTAACTCAGACCTCACTAAAAATCATTTTTGTTTTTATATTGTTATGTCATAAGCTCT
1841 ATTATGTTATTCTAACAAGTAGCAATTTCACAAAATTTGTATGTAGATGTTAACGCACATTTCCTTTGCTTCTTTTATTA
1921 GACTAGTGTTGACTTTGGGGGGGGACATTTATTCACAAATGAGAAGTAGGCACAAAGTAAAAAATGGAACCATCTACTAA
2001 CAAGGATCCTTTAAAACTGCCAAGGGAGCTCTAACTTGAAGCCACATCCTACAGATGGCAGCCCAAATAGCACATGGGCA
2081 ATTGGCACCATCTTTATATGGTTGAGTCTCCTGAATATTTTGAATGAATTCTCAACAAAATGTGCTAGCCACTGGGGACG
2161 CAAAACAAGTAAGATCCCTGTTGCAAGAAATTCATTTTATAGTGAGGGAGGTTGGCATGGAGACTAAAATTCTCAGGAAA
2241 ATGAGATCCGTGTTAGATTAGAAGTCCTGATGTGAAATGGGAGGACTCAGGAAGGAGGATCGTCTTTACCTGAGGATTTC
2321 TAGCCAGAGGTCCCAGATGCCTGGGCTGAGAACCCAGCGATAAGGGGGCGTTCCCAAAGCAGACACAGGGATAAGAACAG
2401 AGGAGGCAGCAGCATTGCACAGCCCCAGGCACAGTGGCAGTTAGGATGGCTGGAGAGTAGGATAGTTCTATGGGTTGCCC
2481 AAAAAATGTGATGCGCTTCATGTTTTCTCTGACTCATGGATCTGGTAGAGACCATAGACATGATATAGACTAACTTCCCC
2561 ATTTTTCACAAGAGGAAACCATCCTTATGACTTACCTTAAAGTTTTTTGTTCTGTTTTGAAGGAAACCATGTGCTTCATG
2641 AAACCTACAGTTGACAAGAGAATGTACAGCTAAGAGAAAAGCTTAAGAGGCCACACTATTCGCGGAATGGCTTTAGAGGC
2721 AGATGAAGTGGTCTTTGACCACAGTTGATTGAACCAGAGCACTTATTGCTTAAAGAATAACAGAGTTCTAGAGCTGGGGG
2801 TTCTTGGGCCATGCTCCGTGTGTGGATAAGGAAAGAAATACTGTTTCTGGGACTCTCCCACAGTCACAAAGCTGTTTTCA
2881 CTGTGGCCCCTACATCTCTTAACTTTTGCTATTACTCCTATGCTGCCTTCCGGATTACTGCTGTCTATCTTCTTGCTCCA
2961 CTCACTGAAGATCCTATTATAATCCCATGAAAATGTAAATTACAGTTTACTTGGGAGAGCCAGATTTTCTCTGTGCTCTT
3041 GAGTTTTTTATTCATTCAAGAAACCTTGGGCCACCGCTTTGTACATAGCACCGTGCTAGGCTCTGGGATCCCAAATGGAC
3121 CCTTTTAACTTTCTGAAGATGGGACCGTCCCCTGGAGGAAAGTCATTCCTGCCTAATCCATCGAGAGAAAGAGGCTTACG
3201 AAAAACTTTGCCTCTGATGCTCAGCCCCACCCCCAAATAGCACACAAGCTTGTTAACCCCACCTCTTACAAAATGTTTAG
3281 ATTCTGTAGGTGTTAAAAGCCTTTCTGGAAGTATTGCATTCTGCCGTGTTTATAGGTGTTCACTTTCCTCCAGAGCTGAT
3361 TAACTACTGACATGACTTGGCTTTCTCATCCAGAAATTATGGAAACAGGGTCTGTCAGTGGCAGGAGGCCGTGCTGTGTT
3441 TTACTTGGATGACACAATGCAGTTTACTTGCCTCTTCATACCCATGCATGCTGCTCACCCTAGACAATGACATATAAGCC
3521 GTATATAGATCAATGTCCACATATATATACACACACACATATATATATATAAAGTGTAACAAGGAACACTAAAACAGTGT
3601 TGATTCTTGTCTCTGAAGACAAATAATTAAACCTTTTTTTTCCCAACTAAAGAATGGATTTAATTAAACTATGTATTGAA
3681 AAAAAAGTAGCCTAAGTGTTAGAGATGGTGAATATATTCCATTTTAGTTAAAGAACAAATTTCCTGAATTTTAAGCATTC
3761 AGTGAGCTGCCAATTTTGATTTTGTGTTGCTCTTTACCCAAATTATTTTTTCTTTGTTTTTCTTTTTTTGGGGGAGGAGG
3841 GGAAAAAAGCAGCAATACTGTGTTTGGAAATTATACTCTGTATCTGGTTTTCCTGTGTATGTTAACCACTTAAATGTTAT
3921 TATCCTGCTTTGGTTTTAGAGTGATTGTGAGGCATTCAATGCAAGTATACAGTTATTTTCTCATTAAAATCCAATGTGTG
4001 TTGAGTTTTTATAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agACAG----AAAACGAUGUGUaa 5'
            ||||    | |   ||||||  
Target 5' aaTGTCCACATATATATACACAca 3'
 3532 - 3555 124.00 -5.79
2 
miRNA  3' agacagaaaacgAUGUGUAa 5'
                      |||||:| 
Target 5' tgggggagtataTACACGTa 3'
 835 - 854 124.00 -5.50
3 
miRNA  3' agACAGA-AAACG-AUGU-GUAa 5'
            ||| | | ||: |||| ||| 
Target 5' tgTGTGTGTGTGTGTACACCATt 3'
 1260 - 1282 122.00 -7.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN6375588 23 COSMIC
COSN16128199 25 COSMIC
COSN30124034 27 COSMIC
COSN31497388 34 COSMIC
COSN30457588 64 COSMIC
COSN28765705 87 COSMIC
COSN30526737 101 COSMIC
COSN17181595 121 COSMIC
COSN30541654 526 COSMIC
COSN26648003 528 COSMIC
COSN30172141 603 COSMIC
COSN31579275 623 COSMIC
COSN31552446 853 COSMIC
COSN31570737 1245 COSMIC
COSN29534713 1274 COSMIC
COSN31531867 1320 COSMIC
COSN23366518 1333 COSMIC
COSN31528370 1334 COSMIC
COSN31519010 1462 COSMIC
COSN8293393 1529 COSMIC
COSN29287766 1595 COSMIC
COSN19471731 1639 COSMIC
COSN2305419 1686 COSMIC
COSN31584168 1723 COSMIC
COSN31542717 1727 COSMIC
COSN31569223 1744 COSMIC
COSN30176559 1770 COSMIC
COSN31555857 1937 COSMIC
COSN23300595 1945 COSMIC
COSN17613698 1946 COSMIC
COSN15268201 2371 COSMIC
COSN24294982 2517 COSMIC
COSN2305421 2792 COSMIC
COSN29339704 3427 COSMIC
COSN31533249 3549 COSMIC
COSN30175658 3551 COSMIC
COSN217029 3559 COSMIC
COSN28654170 3561 COSMIC
COSN21699542 3653 COSMIC
COSN31565047 3688 COSMIC
COSN31546710 3981 COSMIC
COSN26506661 3997 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs748539622 3 dbSNP
rs1391966291 12 dbSNP
rs1322780454 13 dbSNP
rs1329186374 14 dbSNP
rs1406570436 18 dbSNP
rs1304355789 19 dbSNP
rs756483372 22 dbSNP
rs541309382 23 dbSNP
rs1216967645 25 dbSNP
rs1253213454 27 dbSNP
rs1340117633 36 dbSNP
rs749016136 50 dbSNP
rs1265905982 53 dbSNP
rs1006290511 57 dbSNP
rs1014555973 58 dbSNP
rs754831884 66 dbSNP
rs992016555 83 dbSNP
rs961706452 85 dbSNP
rs1396550961 86 dbSNP
rs4978877 87 dbSNP
rs1312350931 93 dbSNP
rs981426948 95 dbSNP
rs1362672046 96 dbSNP
rs924867811 99 dbSNP
rs1453442914 100 dbSNP
rs748110027 101 dbSNP
rs1030100545 118 dbSNP
rs953514844 119 dbSNP
rs1257513612 123 dbSNP
rs146204054 123 dbSNP
rs914808956 127 dbSNP
rs1243750386 130 dbSNP
rs947696554 137 dbSNP
rs1446533407 155 dbSNP
rs772619745 156 dbSNP
rs1176946649 160 dbSNP
rs57519731 161 dbSNP
rs924598337 162 dbSNP
rs1266997628 172 dbSNP
rs1245332306 177 dbSNP
rs1334058992 179 dbSNP
rs563676494 185 dbSNP
rs1412984335 188 dbSNP
rs192648817 195 dbSNP
rs1298974836 196 dbSNP
rs1266297471 203 dbSNP
rs549291139 207 dbSNP
rs1165359109 214 dbSNP
rs868090156 222 dbSNP
rs1458788143 225 dbSNP
rs561215855 226 dbSNP
rs1039993166 236 dbSNP
rs897750583 239 dbSNP
rs894585428 244 dbSNP
rs528269843 247 dbSNP
rs1044936712 252 dbSNP
rs1444920324 261 dbSNP
rs887614466 263 dbSNP
rs1210194614 279 dbSNP
rs1006097219 287 dbSNP
rs1335958551 288 dbSNP
rs1240815335 302 dbSNP
rs1271155732 304 dbSNP
rs1023082978 317 dbSNP
rs1220414734 318 dbSNP
rs1321854448 319 dbSNP
rs546514134 320 dbSNP
rs571289417 324 dbSNP
rs971442119 327 dbSNP
rs897465119 344 dbSNP
rs924565350 366 dbSNP
rs997214045 369 dbSNP
rs1030067931 379 dbSNP
rs1442057337 381 dbSNP
rs1394242545 383 dbSNP
rs1462675901 388 dbSNP
rs115338428 392 dbSNP
rs990849038 400 dbSNP
rs1401748415 401 dbSNP
rs914813716 407 dbSNP
rs550501274 413 dbSNP
rs1474170665 414 dbSNP
rs986697638 423 dbSNP
rs1021763748 431 dbSNP
rs1438606212 433 dbSNP
rs1049894195 441 dbSNP
rs147760949 443 dbSNP
rs1375668069 451 dbSNP
rs977679504 453 dbSNP
rs1040024203 467 dbSNP
rs924894087 468 dbSNP
rs1272274273 469 dbSNP
rs938664834 476 dbSNP
rs1049472698 485 dbSNP
rs1487905673 490 dbSNP
rs992826603 501 dbSNP
rs915986118 506 dbSNP
rs1235318841 509 dbSNP
rs1370630675 510 dbSNP
rs1449543549 524 dbSNP
rs1355606456 540 dbSNP
rs141129729 540 dbSNP
rs1407677460 544 dbSNP
rs555635550 550 dbSNP
rs1396670400 559 dbSNP
rs909022503 562 dbSNP
rs1433715732 576 dbSNP
rs941870865 587 dbSNP
rs1031751221 590 dbSNP
rs185384546 592 dbSNP
rs1232201188 603 dbSNP
rs1179614260 606 dbSNP
rs1436103463 613 dbSNP
rs189965740 614 dbSNP
rs557335178 619 dbSNP
rs1347414478 624 dbSNP
rs1051461804 626 dbSNP
rs888795324 629 dbSNP
rs553312024 630 dbSNP
rs1326263772 636 dbSNP
rs564120658 639 dbSNP
rs1021813247 641 dbSNP
rs371269656 650 dbSNP
rs912696853 651 dbSNP
rs1340170426 653 dbSNP
rs377623584 663 dbSNP
rs999451642 667 dbSNP
rs1413694758 686 dbSNP
rs1373215396 688 dbSNP
rs756455617 697 dbSNP
rs1160124260 701 dbSNP
rs1401035730 702 dbSNP
rs1407006059 703 dbSNP
rs1156675869 705 dbSNP
rs146943604 709 dbSNP
rs1031879700 717 dbSNP
rs1188721485 721 dbSNP
rs575704389 723 dbSNP
rs993045874 729 dbSNP
rs918988496 731 dbSNP
rs193296264 744 dbSNP
rs1048695198 745 dbSNP
rs1373094724 749 dbSNP
rs1359059482 750 dbSNP
rs1294490005 751 dbSNP
rs1463088890 752 dbSNP
rs1232117110 755 dbSNP
rs1353052905 762 dbSNP
rs1161051605 767 dbSNP
rs1299599673 781 dbSNP
rs1431029561 787 dbSNP
rs887709166 789 dbSNP
rs561148539 790 dbSNP
rs1364533908 792 dbSNP
rs1405241871 804 dbSNP
rs970481310 805 dbSNP
rs1347785602 806 dbSNP
rs764544890 816 dbSNP
rs1380969617 821 dbSNP
rs1418447998 822 dbSNP
rs1164168068 823 dbSNP
rs1474895704 827 dbSNP
rs909985604 834 dbSNP
rs1415791548 835 dbSNP
rs1188432238 836 dbSNP
rs1464892195 839 dbSNP
rs948623168 844 dbSNP
rs1044256001 845 dbSNP
rs528389085 849 dbSNP
rs1036237410 852 dbSNP
rs1274307365 852 dbSNP
rs1229668575 853 dbSNP
rs1331953067 855 dbSNP
rs546748543 867 dbSNP
rs1214705819 868 dbSNP
rs1360813159 869 dbSNP
rs1047469 870 dbSNP
rs891852097 872 dbSNP
rs1394976414 878 dbSNP
rs3926310 894 dbSNP
rs1012012711 897 dbSNP
rs1325078791 908 dbSNP
rs1051687017 910 dbSNP
rs762316086 912 dbSNP
rs1172601186 915 dbSNP
rs148005360 919 dbSNP
rs1175745723 920 dbSNP
rs1419033490 921 dbSNP
rs1185028869 922 dbSNP
rs543328551 928 dbSNP
rs985712034 930 dbSNP
rs184763887 933 dbSNP
rs533191553 934 dbSNP
rs41278413 943 dbSNP
rs369390566 950 dbSNP
rs1031763670 961 dbSNP
rs1204570753 962 dbSNP
rs1184749787 967 dbSNP
rs960199663 974 dbSNP
rs1424830610 976 dbSNP
rs1165100871 980 dbSNP
rs1220615628 980 dbSNP
rs370867015 980 dbSNP
rs1014434751 981 dbSNP
rs1452129442 986 dbSNP
rs1438511484 1001 dbSNP
rs539955490 1004 dbSNP
rs1455522777 1017 dbSNP
rs1298717222 1031 dbSNP
rs984864990 1044 dbSNP
rs908841178 1048 dbSNP
rs1168529439 1050 dbSNP
rs1023185485 1061 dbSNP
rs1436821343 1062 dbSNP
rs970069847 1063 dbSNP
rs1193377799 1064 dbSNP
rs1453011442 1073 dbSNP
rs1253240169 1083 dbSNP
rs529621375 1084 dbSNP
rs141701840 1085 dbSNP
rs755601404 1087 dbSNP
rs1384483739 1088 dbSNP
rs1479994602 1118 dbSNP
rs907107741 1121 dbSNP
rs1212487058 1132 dbSNP
rs1279218633 1136 dbSNP
rs1231759178 1137 dbSNP
rs938509557 1138 dbSNP
rs1052919012 1140 dbSNP
rs961794301 1154 dbSNP
rs972820527 1158 dbSNP
rs567914294 1163 dbSNP
rs1372614545 1165 dbSNP
rs76781890 1166 dbSNP
rs180769987 1167 dbSNP
rs1382126613 1174 dbSNP
rs1011627952 1183 dbSNP
rs1173282995 1193 dbSNP
rs933160941 1201 dbSNP
rs1043528177 1204 dbSNP
rs987358866 1205 dbSNP
rs1419004801 1206 dbSNP
rs910490197 1209 dbSNP
rs933531971 1215 dbSNP
rs1214766894 1230 dbSNP
rs1261141389 1233 dbSNP
rs1486805807 1239 dbSNP
rs1019852793 1244 dbSNP
rs1241924209 1247 dbSNP
rs1256314470 1249 dbSNP
rs1444739738 1252 dbSNP
rs1025771344 1256 dbSNP
rs1356202801 1256 dbSNP
rs138342860 1256 dbSNP
rs576798948 1256 dbSNP
rs762083114 1256 dbSNP
rs943045723 1256 dbSNP
rs113910969 1257 dbSNP
rs1312442896 1258 dbSNP
rs1413175921 1260 dbSNP
rs1043148657 1263 dbSNP
rs1387506517 1270 dbSNP
rs535009452 1272 dbSNP
rs1405310791 1280 dbSNP
rs904194777 1286 dbSNP
rs934369927 1288 dbSNP
rs1167773787 1300 dbSNP
rs1475219829 1309 dbSNP
rs199669619 1316 dbSNP
rs757526891 1316 dbSNP
rs141063967 1318 dbSNP
rs372406995 1318 dbSNP
rs766374730 1318 dbSNP
rs796396063 1318 dbSNP
rs546276389 1320 dbSNP
rs1274921577 1322 dbSNP
rs895958432 1330 dbSNP
rs969742589 1354 dbSNP
rs1014403479 1355 dbSNP
rs1328399775 1361 dbSNP
rs928557011 1365 dbSNP
rs1335330047 1367 dbSNP
rs1023154402 1369 dbSNP
rs1383285473 1384 dbSNP
rs1328443423 1390 dbSNP
rs938542180 1404 dbSNP
rs12340651 1406 dbSNP
rs1162155323 1409 dbSNP
rs773508039 1410 dbSNP
rs1453512292 1424 dbSNP
rs1005544244 1429 dbSNP
rs539266374 1430 dbSNP
rs557467249 1431 dbSNP
rs1192054442 1433 dbSNP
rs575840309 1433 dbSNP
rs540818571 1438 dbSNP
rs1371426271 1452 dbSNP
rs1254664810 1453 dbSNP
rs1194104325 1463 dbSNP
rs1467970059 1470 dbSNP
rs1271245538 1477 dbSNP
rs947207604 1493 dbSNP
rs150450632 1494 dbSNP
rs1307360651 1502 dbSNP
rs1341604077 1508 dbSNP
rs1318519707 1514 dbSNP
rs889854050 1517 dbSNP
rs771979504 1524 dbSNP
rs1262466940 1525 dbSNP
rs4978878 1528 dbSNP
rs1040999638 1532 dbSNP
rs185765940 1533 dbSNP
rs1029767538 1544 dbSNP
rs954517131 1552 dbSNP
rs11681 1553 dbSNP
rs758464161 1556 dbSNP
rs189987706 1560 dbSNP
rs181202177 1561 dbSNP
rs774948314 1562 dbSNP
rs1194001259 1571 dbSNP
rs1177427700 1578 dbSNP
rs1453612498 1581 dbSNP
rs1251020972 1584 dbSNP
rs1006113760 1585 dbSNP
rs910460273 1594 dbSNP
rs540169333 1599 dbSNP
rs1195370230 1603 dbSNP
rs978700841 1604 dbSNP
rs1340287815 1605 dbSNP
rs1282797223 1608 dbSNP
rs1174851678 1612 dbSNP
rs925585239 1613 dbSNP
rs1347638332 1619 dbSNP
rs1273526501 1639 dbSNP
rs1444993475 1641 dbSNP
rs934340829 1642 dbSNP
rs1327582940 1648 dbSNP
rs1052789410 1649 dbSNP
rs777827592 1650 dbSNP
rs1376859402 1652 dbSNP
rs187162527 1661 dbSNP
rs1422819524 1665 dbSNP
rs1352844348 1668 dbSNP
rs1470470103 1681 dbSNP
rs1441675026 1682 dbSNP
rs913123294 1690 dbSNP
rs1298984989 1692 dbSNP
rs769950006 1695 dbSNP
rs1259815200 1701 dbSNP
rs796652703 1703 dbSNP
rs1402842987 1707 dbSNP
rs1282457625 1708 dbSNP
rs1324173623 1710 dbSNP
rs1276938684 1714 dbSNP
rs1279525026 1714 dbSNP
rs947270981 1714 dbSNP
rs978972012 1714 dbSNP
rs1225994058 1715 dbSNP
rs41305613 1721 dbSNP
rs911324395 1722 dbSNP
rs1225350854 1723 dbSNP
rs1313049917 1725 dbSNP
rs942748439 1726 dbSNP
rs1044992741 1728 dbSNP
rs1357139274 1728 dbSNP
rs544031166 1729 dbSNP
rs1384124408 1731 dbSNP
rs901213661 1731 dbSNP
rs1006177781 1734 dbSNP
rs1156884952 1734 dbSNP
rs200831080 1735 dbSNP
rs929974002 1735 dbSNP
rs1234282495 1744 dbSNP
rs1489742921 1745 dbSNP
rs1255475635 1746 dbSNP
rs1474994138 1746 dbSNP
rs1235992369 1749 dbSNP
rs879425856 1750 dbSNP
rs1447964584 1751 dbSNP
rs1268693502 1759 dbSNP
rs1047332743 1764 dbSNP
rs562229786 1764 dbSNP
rs1293371812 1765 dbSNP
rs1481046864 1769 dbSNP
rs888682033 1770 dbSNP
rs529755179 1771 dbSNP
rs1376493054 1780 dbSNP
rs1271611581 1782 dbSNP
rs1409485591 1783 dbSNP
rs547736399 1786 dbSNP
rs1171272526 1793 dbSNP
rs1431144829 1794 dbSNP
rs1344400984 1798 dbSNP
rs1318381058 1799 dbSNP
rs566353905 1810 dbSNP
rs1395200904 1819 dbSNP
rs767027278 1820 dbSNP
rs1165718153 1825 dbSNP
rs1404877136 1831 dbSNP
rs775386786 1832 dbSNP
rs1423044116 1833 dbSNP
rs138285534 1838 dbSNP
rs994200497 1839 dbSNP
rs1187142035 1840 dbSNP
rs1470210808 1843 dbSNP
rs191416371 1853 dbSNP
rs1212488331 1859 dbSNP
rs571935463 1866 dbSNP
rs1274604395 1869 dbSNP
rs539217478 1882 dbSNP
rs1001319858 1893 dbSNP
rs559891559 1895 dbSNP
rs569342044 1896 dbSNP
rs1371596694 1898 dbSNP
rs1360608109 1903 dbSNP
rs1006985600 1906 dbSNP
rs1348224590 1911 dbSNP
rs183246094 1912 dbSNP
rs1410743945 1929 dbSNP
rs964592039 1935 dbSNP
rs1167077503 1936 dbSNP
rs1254132797 1937 dbSNP
rs202059217 1937 dbSNP
rs969015625 1938 dbSNP
rs879438345 1939 dbSNP
rs925921542 1940 dbSNP
rs1490622660 1943 dbSNP
rs1201594916 1944 dbSNP
rs777531457 1945 dbSNP
rs942526651 1946 dbSNP
rs1375533616 1948 dbSNP
rs1240833038 1955 dbSNP
rs1475405005 1971 dbSNP
rs1299956979 1981 dbSNP
rs1443087180 1986 dbSNP
rs1370155075 1990 dbSNP
rs976842272 2006 dbSNP
rs746771694 2008 dbSNP
rs554965282 2009 dbSNP
rs955685991 2016 dbSNP
rs573147509 2032 dbSNP
rs930020734 2035 dbSNP
rs1431929712 2037 dbSNP
rs1410864071 2042 dbSNP
rs1392177509 2043 dbSNP
rs1249096703 2046 dbSNP
rs1442940721 2048 dbSNP
rs540670874 2053 dbSNP
rs916989925 2060 dbSNP
rs1365909001 2069 dbSNP
rs1255194005 2070 dbSNP
rs1406905752 2075 dbSNP
rs1318636366 2076 dbSNP
rs1426296623 2077 dbSNP
rs949771695 2086 dbSNP
rs1047484080 2088 dbSNP
rs1316005358 2093 dbSNP
rs558551676 2093 dbSNP
rs752219609 2099 dbSNP
rs1349973660 2100 dbSNP
rs1286623060 2102 dbSNP
rs768698363 2109 dbSNP
rs774846221 2133 dbSNP
rs1431464777 2134 dbSNP
rs1376356364 2143 dbSNP
rs1302611100 2146 dbSNP
rs941576977 2150 dbSNP
rs1045336384 2158 dbSNP
rs927430749 2160 dbSNP
rs1315351140 2161 dbSNP
rs1361203250 2169 dbSNP
rs1409132287 2169 dbSNP
rs10980232 2182 dbSNP
rs1189533002 2196 dbSNP
rs147598008 2199 dbSNP
rs376592255 2200 dbSNP
rs369865728 2201 dbSNP
rs577103558 2201 dbSNP
rs1446930023 2205 dbSNP
rs543970448 2218 dbSNP
rs1217142487 2219 dbSNP
rs1003695847 2221 dbSNP
rs1039015833 2224 dbSNP
rs897435817 2231 dbSNP
rs994168234 2236 dbSNP
rs528469142 2240 dbSNP
rs891132563 2241 dbSNP
rs548619826 2248 dbSNP
rs1018373116 2250 dbSNP
rs964888993 2251 dbSNP
rs1289891724 2264 dbSNP
rs1156579177 2267 dbSNP
rs1457176100 2269 dbSNP
rs1020330001 2271 dbSNP
rs28369085 2273 dbSNP
rs979120704 2274 dbSNP
rs768063159 2284 dbSNP
rs955991603 2296 dbSNP
rs1430022621 2297 dbSNP
rs976539544 2298 dbSNP
rs773679682 2302 dbSNP
rs988698000 2303 dbSNP
rs761119767 2309 dbSNP
rs1275016075 2310 dbSNP
rs1336873841 2311 dbSNP
rs922700143 2327 dbSNP
rs1341884543 2340 dbSNP
rs1236521690 2355 dbSNP
rs1265023207 2357 dbSNP
rs1242883327 2358 dbSNP
rs951508152 2359 dbSNP
rs541514768 2360 dbSNP
rs765926462 2370 dbSNP
rs916875739 2371 dbSNP
rs971056197 2374 dbSNP
rs980232797 2376 dbSNP
rs1460399230 2381 dbSNP
rs941368119 2382 dbSNP
rs1045365854 2384 dbSNP
rs1161028602 2391 dbSNP
rs1463186843 2406 dbSNP
rs1203085758 2408 dbSNP
rs1373341230 2409 dbSNP
rs1167692971 2412 dbSNP
rs186140722 2416 dbSNP
rs1254758389 2421 dbSNP
rs939514678 2422 dbSNP
rs1452180705 2423 dbSNP
rs1266752357 2429 dbSNP
rs1208202572 2431 dbSNP
rs1341711908 2436 dbSNP
rs1444340294 2438 dbSNP
rs1275675907 2446 dbSNP
rs1228079561 2447 dbSNP
rs941508312 2449 dbSNP
rs1179931666 2455 dbSNP
rs1306199060 2466 dbSNP
rs753219197 2471 dbSNP
rs755649979 2472 dbSNP
rs527270461 2475 dbSNP
rs918765271 2476 dbSNP
rs1232034147 2478 dbSNP
rs878899611 2481 dbSNP
rs4289885 2495 dbSNP
rs374494980 2499 dbSNP
rs895568618 2501 dbSNP
rs12685208 2502 dbSNP
rs1307049940 2513 dbSNP
rs1469281280 2518 dbSNP
rs10980233 2523 dbSNP
rs891100963 2524 dbSNP
rs1427513522 2526 dbSNP
rs146155403 2527 dbSNP
rs904224883 2533 dbSNP
rs1040173532 2534 dbSNP
rs1477647530 2538 dbSNP
rs1375910246 2541 dbSNP
rs1389267005 2545 dbSNP
rs1439669391 2547 dbSNP
rs1252754884 2548 dbSNP
rs1327797547 2557 dbSNP
rs1482240164 2558 dbSNP
rs1282908207 2561 dbSNP
rs1201435042 2565 dbSNP
rs1344884766 2586 dbSNP
rs1335500948 2591 dbSNP
rs999843977 2593 dbSNP
rs1240501843 2597 dbSNP
rs1350579416 2599 dbSNP
rs903975373 2603 dbSNP
rs1407607751 2606 dbSNP
rs41301541 2611 dbSNP
rs1334543050 2614 dbSNP
rs1032773831 2627 dbSNP
rs1290647005 2629 dbSNP
rs1471167860 2633 dbSNP
rs752585036 2640 dbSNP
rs569485839 2650 dbSNP
rs891634994 2652 dbSNP
rs141952081 2656 dbSNP
rs1024190667 2664 dbSNP
rs1277052583 2669 dbSNP
rs761544283 2677 dbSNP
rs1256595384 2682 dbSNP
rs189771566 2691 dbSNP
rs979817827 2696 dbSNP
rs1034513494 2702 dbSNP
rs182305930 2703 dbSNP
rs1226091070 2704 dbSNP
rs963899577 2705 dbSNP
rs962528305 2707 dbSNP
rs796585871 2717 dbSNP
rs1338503273 2729 dbSNP
rs1320130521 2732 dbSNP
rs1029418799 2733 dbSNP
rs974230793 2744 dbSNP
rs918732655 2745 dbSNP
rs930138983 2767 dbSNP
rs1184065588 2776 dbSNP
rs987037944 2778 dbSNP
rs1455737821 2781 dbSNP
rs144699402 2786 dbSNP
rs942691582 2787 dbSNP
rs909949556 2793 dbSNP
rs1039739993 2795 dbSNP
rs1472633421 2796 dbSNP
rs1200083256 2801 dbSNP
rs1378817655 2809 dbSNP
rs903860700 2812 dbSNP
rs562149426 2814 dbSNP
rs576699602 2818 dbSNP
rs1052490481 2819 dbSNP
rs891602563 2830 dbSNP
rs1010055422 2831 dbSNP
rs537757582 2839 dbSNP
rs1431309330 2853 dbSNP
rs1271702890 2854 dbSNP
rs1435608024 2856 dbSNP
rs374214657 2857 dbSNP
rs113042873 2858 dbSNP
rs907158059 2859 dbSNP
rs1001602168 2861 dbSNP
rs1432916613 2865 dbSNP
rs1344028681 2866 dbSNP
rs1351691109 2867 dbSNP
rs1033978293 2868 dbSNP
rs1165649633 2875 dbSNP
rs1404968941 2883 dbSNP
rs962710184 2884 dbSNP
rs1170836468 2891 dbSNP
rs79029795 2897 dbSNP
rs1390049777 2901 dbSNP
rs1187247500 2903 dbSNP
rs1302611895 2909 dbSNP
rs1025425706 2921 dbSNP
rs1333373697 2930 dbSNP
rs186576837 2932 dbSNP
rs987006983 2933 dbSNP
rs1274729772 2934 dbSNP
rs541649655 2935 dbSNP
rs759611589 2940 dbSNP
rs1250889796 2941 dbSNP
rs1368285909 2943 dbSNP
rs751571813 2944 dbSNP
rs370535149 2946 dbSNP
rs1207568447 2954 dbSNP
rs1310115950 2956 dbSNP
rs976074305 2959 dbSNP
rs191599836 2968 dbSNP
rs1056653622 2971 dbSNP
rs1435413257 2972 dbSNP
rs1426546976 2981 dbSNP
rs10125067 3005 dbSNP
rs531090080 3006 dbSNP
rs1476767412 3012 dbSNP
rs566647256 3018 dbSNP
rs1052458529 3023 dbSNP
rs780190315 3037 dbSNP
rs1482562141 3039 dbSNP
rs1272190243 3041 dbSNP
rs1210321783 3045 dbSNP
rs749327965 3048 dbSNP
rs1212811927 3056 dbSNP
rs1269333362 3064 dbSNP
rs904257017 3066 dbSNP
rs1218674042 3067 dbSNP
rs999830234 3071 dbSNP
rs1290378806 3072 dbSNP
rs1410666539 3073 dbSNP
rs892577011 3076 dbSNP
rs945883334 3077 dbSNP
rs1467939061 3078 dbSNP
rs1039319742 3093 dbSNP
rs768981720 3094 dbSNP
rs1191825537 3097 dbSNP
rs1412202745 3100 dbSNP
rs1373211106 3103 dbSNP
rs907039875 3104 dbSNP
rs1001434017 3108 dbSNP
rs142885351 3112 dbSNP
rs1183337195 3120 dbSNP
rs898145713 3131 dbSNP
rs1255284230 3138 dbSNP
rs564109610 3140 dbSNP
rs1331231286 3142 dbSNP
rs1270078922 3147 dbSNP
rs1017448218 3148 dbSNP
rs1350071388 3150 dbSNP
rs1286724010 3161 dbSNP
rs1393501988 3162 dbSNP
rs962805476 3163 dbSNP
rs1381088640 3169 dbSNP
rs1025396170 3173 dbSNP
rs1294867149 3182 dbSNP
rs748191493 3183 dbSNP
rs1007987894 3184 dbSNP
rs960688348 3186 dbSNP
rs1159215812 3190 dbSNP
rs1457330915 3200 dbSNP
rs62578884 3201 dbSNP
rs914137842 3207 dbSNP
rs1267052161 3208 dbSNP
rs1255216299 3221 dbSNP
rs964579837 3231 dbSNP
rs773505987 3234 dbSNP
rs945563001 3236 dbSNP
rs551289624 3239 dbSNP
rs1209396385 3246 dbSNP
rs1328611804 3250 dbSNP
rs975662965 3253 dbSNP
rs925555590 3268 dbSNP
rs935719750 3277 dbSNP
rs958015749 3280 dbSNP
rs559844576 3286 dbSNP
rs1181327875 3290 dbSNP
rs988142509 3291 dbSNP
rs1321831266 3293 dbSNP
rs117080443 3300 dbSNP
rs933642357 3306 dbSNP
rs1294847851 3312 dbSNP
rs1458088353 3314 dbSNP
rs1367583777 3319 dbSNP
rs1162394854 3323 dbSNP
rs1451134793 3327 dbSNP
rs1051482259 3334 dbSNP
rs1187855889 3341 dbSNP
rs887002356 3342 dbSNP
rs771337309 3345 dbSNP
rs1046481478 3353 dbSNP
rs1016730157 3355 dbSNP
rs898588236 3356 dbSNP
rs1244172735 3357 dbSNP
rs1452194862 3362 dbSNP
rs928457326 3373 dbSNP
rs776258994 3383 dbSNP
rs758943750 3388 dbSNP
rs1228310595 3397 dbSNP
rs937199016 3402 dbSNP
rs368256079 3409 dbSNP
rs530296859 3411 dbSNP
rs879206558 3418 dbSNP
rs1445155620 3427 dbSNP
rs548799633 3429 dbSNP
rs995162753 3431 dbSNP
rs150554723 3432 dbSNP
rs534322601 3434 dbSNP
rs992157855 3439 dbSNP
rs182969092 3458 dbSNP
rs199897854 3470 dbSNP
rs966962318 3471 dbSNP
rs1379340207 3479 dbSNP
rs980010313 3481 dbSNP
rs1314922567 3482 dbSNP
rs925510216 3484 dbSNP
rs188706510 3485 dbSNP
rs943539409 3486 dbSNP
rs537895389 3490 dbSNP
rs556016245 3501 dbSNP
rs1331203539 3506 dbSNP
rs1201216621 3513 dbSNP
rs1204956475 3520 dbSNP
rs140521657 3521 dbSNP
rs372668449 3522 dbSNP
rs997447930 3524 dbSNP
rs1032595194 3530 dbSNP
rs958318097 3534 dbSNP
rs1417740686 3536 dbSNP
rs1411259360 3537 dbSNP
rs548996541 3539 dbSNP
rs939918062 3543 dbSNP
rs1038683366 3549 dbSNP
rs551304907 3549 dbSNP
rs570274032 3549 dbSNP
rs913867258 3551 dbSNP
rs970713587 3553 dbSNP
rs535259584 3555 dbSNP
rs1473682864 3557 dbSNP
rs1252862945 3559 dbSNP
rs753859653 3559 dbSNP
rs762379704 3559 dbSNP
rs926722093 3559 dbSNP
rs1281276017 3560 dbSNP
rs41278415 3561 dbSNP
rs1405442737 3563 dbSNP
rs192813685 3566 dbSNP
rs1056066952 3584 dbSNP
rs1229736229 3590 dbSNP
rs1350679125 3590 dbSNP
rs919766011 3592 dbSNP
rs1342044921 3596 dbSNP
rs1439677296 3596 dbSNP
rs1020914326 3598 dbSNP
rs931177901 3604 dbSNP
rs1403881288 3607 dbSNP
rs1047032983 3608 dbSNP
rs1458918915 3621 dbSNP
rs557149184 3624 dbSNP
rs1158726832 3625 dbSNP
rs185006979 3629 dbSNP
rs565708951 3634 dbSNP
rs964877012 3634 dbSNP
rs1188737990 3635 dbSNP
rs1442313848 3637 dbSNP
rs1352249707 3642 dbSNP
rs943715521 3642 dbSNP
rs1040781289 3644 dbSNP
rs1210003717 3652 dbSNP
rs899621755 3672 dbSNP
rs760088114 3674 dbSNP
rs187759319 3676 dbSNP
rs1284548747 3679 dbSNP
rs77361828 3679 dbSNP
rs986880761 3679 dbSNP
rs77579038 3680 dbSNP
rs10980234 3696 dbSNP
rs893980928 3699 dbSNP
rs1009743890 3701 dbSNP
rs1211753584 3703 dbSNP
rs939678262 3706 dbSNP
rs1021189425 3709 dbSNP
rs1038312053 3712 dbSNP
rs41278417 3714 dbSNP
rs982558392 3715 dbSNP
rs10980235 3728 dbSNP
rs1181891089 3730 dbSNP
rs1234636178 3734 dbSNP
rs1054941444 3735 dbSNP
rs1383866926 3737 dbSNP
rs1191058968 3739 dbSNP
rs1253067442 3741 dbSNP
rs1246869737 3744 dbSNP
rs1213095862 3755 dbSNP
rs959686172 3763 dbSNP
rs896573646 3765 dbSNP
rs973515274 3773 dbSNP
rs1013636172 3774 dbSNP
rs555283065 3777 dbSNP
rs1197905122 3784 dbSNP
rs919733650 3798 dbSNP
rs1299649874 3802 dbSNP
rs1229049890 3808 dbSNP
rs1364431000 3813 dbSNP
rs780978643 3816 dbSNP
rs1428755838 3823 dbSNP
rs183894220 3830 dbSNP
rs35078924 3830 dbSNP
rs1324469949 3831 dbSNP
rs1424346300 3838 dbSNP
rs534709533 3839 dbSNP
rs1170935987 3841 dbSNP
rs908484340 3844 dbSNP
rs1450615014 3847 dbSNP
rs1419476259 3852 dbSNP
rs1461733419 3856 dbSNP
rs1478738038 3861 dbSNP
rs1246874718 3875 dbSNP
rs1221291362 3877 dbSNP
rs1489760192 3879 dbSNP
rs1308337429 3891 dbSNP
rs943716420 3898 dbSNP
rs1032569612 3902 dbSNP
rs964910321 3914 dbSNP
rs1341318920 3916 dbSNP
rs189162592 3921 dbSNP
rs996305542 3929 dbSNP
rs1282599444 3935 dbSNP
rs1212817874 3944 dbSNP
rs1369823835 3952 dbSNP
rs1030424181 3955 dbSNP
rs181401435 3960 dbSNP
rs1343926439 3961 dbSNP
rs899506559 3967 dbSNP
rs1430836501 3987 dbSNP
rs571477357 3995 dbSNP
rs1306552666 4005 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 11217.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714646. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 11217.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM714642
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000374525.1 | 3UTR | CACAUAUAUAUACACACACACAUAUAUAUAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000374525.1 | 3UTR | AUAUACACACACACAUAUAUAUAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000374525.1 | 3UTR | UCCACAUAUAUAUACACACACACAUAUAUAUAUAUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000374525.1 | 3UTR | AUAUAUAUACACACACACAUAUAUAUAUAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM714646
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repA
Location of target site ENST00000374525.1 | 3UTR | AUAUACACACACACAUAUAUAUAUAUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000374525.1 | 3UTR | UCCACAUAUAUAUACACACACACAUAUAUAUAUAUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000374525.1 | 3UTR | UAUAUAUACACACACACAUAUAUAUAUAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
239 hsa-miR-511-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT068303 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT072025 SCP2 sterol carrier protein 2 2 2
MIRT073626 IGF1R insulin like growth factor 1 receptor 2 2
MIRT080574 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 8
MIRT094167 PCGF3 polycomb group ring finger 3 2 4
MIRT096536 LIFR LIF receptor alpha 2 2
MIRT156224 SLC25A12 solute carrier family 25 member 12 2 2
MIRT177714 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT184922 ZNF268 zinc finger protein 268 2 2
MIRT185107 LYPLAL1 lysophospholipase like 1 2 2
MIRT193093 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT213346 TADA2B transcriptional adaptor 2B 2 2
MIRT225350 SDCBP syndecan binding protein 2 2
MIRT226972 AKAP2 A-kinase anchoring protein 2 2 6
MIRT226977 PALM2-AKAP2 PALM2-AKAP2 readthrough 2 6
MIRT229844 YIPF6 Yip1 domain family member 6 2 2
MIRT230994 PRRG4 proline rich and Gla domain 4 2 2
MIRT270215 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 2 4
MIRT277060 NDFIP2 Nedd4 family interacting protein 2 2 4
MIRT278336 CFL2 cofilin 2 2 4
MIRT280390 CALM1 calmodulin 1 2 2
MIRT298042 BACH1 BTB domain and CNC homolog 1 2 2
MIRT302449 CLIP4 CAP-Gly domain containing linker protein family member 4 2 2
MIRT311937 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 4
MIRT329263 AIMP1 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 2 2
MIRT359186 F2RL1 F2R like trypsin receptor 1 2 6
MIRT363208 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT371124 YTHDC1 YTH domain containing 1 2 2
MIRT386755 TAOK1 TAO kinase 1 2 2
MIRT395122 BAHD1 bromo adjacent homology domain containing 1 2 2
MIRT396089 MKLN1 muskelin 1 2 2
MIRT443566 EVX2 even-skipped homeobox 2 2 2
MIRT447626 CUL3 cullin 3 2 2
MIRT447680 ZNF264 zinc finger protein 264 2 2
MIRT451053 NT5C1B 5'-nucleotidase, cytosolic IB 2 2
MIRT452048 NT5C1B-RDH14 NT5C1B-RDH14 readthrough 2 2
MIRT459890 KIAA1191 KIAA1191 2 4
MIRT464483 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465264 TRIM44 tripartite motif containing 44 2 2
MIRT467570 SLITRK4 SLIT and NTRK like family member 4 2 2
MIRT467800 SLC2A14 solute carrier family 2 member 14 2 2
MIRT469543 RASAL2 RAS protein activator like 2 2 2
MIRT469931 PTPRJ protein tyrosine phosphatase, receptor type J 2 4
MIRT474056 LMNB2 lamin B2 2 2
MIRT474097 LMBR1L limb development membrane protein 1 like 2 2
MIRT475183 INSIG2 insulin induced gene 2 2 6
MIRT484264 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT487567 LOXL2 lysyl oxidase like 2 2 2
MIRT499080 CBWD1 COBW domain containing 1 2 6
MIRT499126 CBWD5 COBW domain containing 5 2 6
MIRT502093 KPNA5 karyopherin subunit alpha 5 2 8
MIRT503328 SOX5 SRY-box 5 2 6
MIRT503839 NCAM2 neural cell adhesion molecule 2 2 6
MIRT504030 CEP104 centrosomal protein 104 2 4
MIRT504314 LHFPL5 LHFPL tetraspan subfamily member 5 2 8
MIRT504525 BVES blood vessel epicardial substance 2 6
MIRT504680 CYGB cytoglobin 2 4
MIRT504815 DOCK7 dedicator of cytokinesis 7 2 4
MIRT505757 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT506151 PLEKHA3 pleckstrin homology domain containing A3 2 6
MIRT506908 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 6
MIRT508259 CD226 CD226 molecule 2 2
MIRT508307 XRCC3 X-ray repair cross complementing 3 2 4
MIRT508784 CDKL1 cyclin dependent kinase like 1 2 6
MIRT508897 C4orf29 abhydrolase domain containing 18 2 6
MIRT508967 TECRL trans-2,3-enoyl-CoA reductase like 2 4
MIRT508973 MLLT3 MLLT3, super elongation complex subunit 2 6
MIRT509149 TSC22D3 TSC22 domain family member 3 2 4
MIRT509188 TSPAN2 tetraspanin 2 2 4
MIRT509212 BRCC3 BRCA1/BRCA2-containing complex subunit 3 2 4
MIRT509214 SEC23IP SEC23 interacting protein 2 6
MIRT509237 PDE10A phosphodiesterase 10A 2 6
MIRT509248 OTX1 orthodenticle homeobox 1 2 6
MIRT509469 TRIM2 tripartite motif containing 2 2 4
MIRT509754 EFCAB11 EF-hand calcium binding domain 11 2 4
MIRT509805 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT509938 USP25 ubiquitin specific peptidase 25 2 4
MIRT509954 ITGA1 integrin subunit alpha 1 2 6
MIRT509965 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 4
MIRT509988 GTF2H1 general transcription factor IIH subunit 1 2 4
MIRT510036 NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 2 6
MIRT510164 STARD8 StAR related lipid transfer domain containing 8 2 4
MIRT510199 CYP4F11 cytochrome P450 family 4 subfamily F member 11 2 9
MIRT510249 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 6
MIRT510502 YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta 2 2
MIRT510906 PURA purine rich element binding protein A 2 4
MIRT511051 NRF1 nuclear respiratory factor 1 2 4
MIRT511273 KLHL23 kelch like family member 23 2 4
MIRT511368 IL6ST interleukin 6 signal transducer 2 4
MIRT511521 HMGB2 high mobility group box 2 2 4
MIRT512004 DUSP7 dual specificity phosphatase 7 2 4
MIRT512080 CSRNP3 cysteine and serine rich nuclear protein 3 2 8
MIRT514234 EPOR erythropoietin receptor 2 4
MIRT515327 SLC35E3 solute carrier family 35 member E3 2 4
MIRT515409 WDR72 WD repeat domain 72 2 8
MIRT515973 C9orf156 tRNA methyltransferase O 2 4
MIRT516015 NLGN3 neuroligin 3 2 4
MIRT516271 DBT dihydrolipoamide branched chain transacylase E2 2 10
MIRT516495 GLRX2 glutaredoxin 2 2 4
MIRT517272 ANG angiogenin 2 4
MIRT517511 KCNK12 potassium two pore domain channel subfamily K member 12 2 4
MIRT517555 VENTX VENT homeobox 2 4
MIRT519511 RBM22 RNA binding motif protein 22 2 4
MIRT520350 UBN2 ubinuclein 2 2 2
MIRT520687 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT520960 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT521759 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT522036 PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 2 4
MIRT522127 NELL2 neural EGFL like 2 2 4
MIRT522624 MAP7D1 MAP7 domain containing 1 2 4
MIRT522761 LDLR low density lipoprotein receptor 2 6
MIRT522924 KAT6A lysine acetyltransferase 6A 2 6
MIRT523391 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 4
MIRT523851 ETV6 ETS variant 6 2 2
MIRT523890 EPHA5 EPH receptor A5 2 4
MIRT523945 E2F8 E2F transcription factor 8 2 4
MIRT524222 DCUN1D3 defective in cullin neddylation 1 domain containing 3 2 2
MIRT524410 CNTNAP5 contactin associated protein like 5 2 4
MIRT524568 CALML4 calmodulin like 4 2 4
MIRT524611 ENTHD1 ENTH domain containing 1 2 2
MIRT524907 AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2 4
MIRT525019 ABHD13 abhydrolase domain containing 13 2 6
MIRT525211 C19orf12 chromosome 19 open reading frame 12 2 2
MIRT528253 BMS1 BMS1, ribosome biogenesis factor 2 2
MIRT528294 ZNF76 zinc finger protein 76 2 2
MIRT531898 INVS inversin 2 4
MIRT535962 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT540823 SSPN sarcospan 2 4
MIRT541836 CDON cell adhesion associated, oncogene regulated 2 4
MIRT541914 BMPR1A bone morphogenetic protein receptor type 1A 2 4
MIRT542156 KIAA2018 upstream transcription factor family member 3 2 6
MIRT542175 SERTM1 serine rich and transmembrane domain containing 1 2 6
MIRT542217 IRS1 insulin receptor substrate 1 2 4
MIRT542225 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 6
MIRT543654 PLEKHM3 pleckstrin homology domain containing M3 2 2
MIRT544097 EDA2R ectodysplasin A2 receptor 2 2
MIRT544533 SPPL3 signal peptide peptidase like 3 2 2
MIRT544954 TUB tubby bipartite transcription factor 2 4
MIRT545027 PLP1 proteolipid protein 1 2 2
MIRT546524 SERTAD3 SERTA domain containing 3 2 2
MIRT547242 OSBPL9 oxysterol binding protein like 9 2 4
MIRT548198 FNIP1 folliculin interacting protein 1 2 2
MIRT548272 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT549480 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT549498 ABI2 abl interactor 2 2 2
MIRT550325 SMAD9 SMAD family member 9 2 2
MIRT550563 CYP4V2 cytochrome P450 family 4 subfamily V member 2 2 6
MIRT550642 AR androgen receptor 2 2
MIRT550945 CTSE cathepsin E 2 4
MIRT550961 POT1 protection of telomeres 1 2 2
MIRT551178 ATP7A ATPase copper transporting alpha 2 2
MIRT551416 LRRC31 leucine rich repeat containing 31 2 2
MIRT551507 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2 2
MIRT551517 MMADHC methylmalonic aciduria and homocystinuria, cblD type 2 2
MIRT551550 TMEM133 transmembrane protein 133 2 2
MIRT551757 TRIM42 tripartite motif containing 42 2 2
MIRT551872 TMEM47 transmembrane protein 47 2 2
MIRT551882 EPHA1 EPH receptor A1 2 2
MIRT551917 IGLON5 IgLON family member 5 2 2
MIRT552377 ZNF562 zinc finger protein 562 2 2
MIRT552543 ZHX3 zinc fingers and homeoboxes 3 2 2
MIRT553419 TRAF5 TNF receptor associated factor 5 2 2
MIRT554080 SNX4 sorting nexin 4 2 4
MIRT554588 RRAGC Ras related GTP binding C 2 2
MIRT554887 RCC2 regulator of chromosome condensation 2 2 2
MIRT555568 PLCB1 phospholipase C beta 1 2 2
MIRT555819 PCDH11Y protocadherin 11 Y-linked 2 4
MIRT555969 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT556028 MXD1 MAX dimerization protein 1 2 2
MIRT556206 MBNL2 muscleblind like splicing regulator 2 2 2
MIRT556251 MARCH3 membrane associated ring-CH-type finger 3 2 2
MIRT557265 HMGN3 high mobility group nucleosomal binding domain 3 2 2
MIRT557334 HHIP hedgehog interacting protein 2 2
MIRT557427 GXYLT2 glucoside xylosyltransferase 2 2 4
MIRT557537 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT557797 FREM2 FRAS1 related extracellular matrix protein 2 2 2
MIRT557805 FOXP1 forkhead box P1 2 2
MIRT558569 CRIM1 cysteine rich transmembrane BMP regulator 1 2 2
MIRT558734 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT558878 CCSER2 coiled-coil serine rich protein 2 2 2
MIRT558933 CBX1 chromobox 1 2 2
MIRT559133 BTG3 BTG anti-proliferation factor 3 2 4
MIRT559168 BRWD3 bromodomain and WD repeat domain containing 3 2 4
MIRT559618 AMER1 APC membrane recruitment protein 1 2 2
MIRT561627 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT561971 LRRC59 leucine rich repeat containing 59 2 2
MIRT563049 ZNF138 zinc finger protein 138 2 2
MIRT563432 TRIM13 tripartite motif containing 13 2 4
MIRT563540 RBM41 RNA binding motif protein 41 2 2
MIRT564647 ZNF544 zinc finger protein 544 2 2
MIRT567674 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT567755 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT568267 BICD2 BICD cargo adaptor 2 2 2
MIRT569160 SIGMAR1 sigma non-opioid intracellular receptor 1 2 2
MIRT569179 DMD dystrophin 2 2
MIRT569427 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569853 RGS5 regulator of G protein signaling 5 2 2
MIRT570554 PLAG1 PLAG1 zinc finger 2 2
MIRT571233 SYT9 synaptotagmin 9 2 2
MIRT572276 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT572539 ZFHX2 zinc finger homeobox 2 2 2
MIRT574271 ZNF350 zinc finger protein 350 2 2
MIRT574428 SMC1A structural maintenance of chromosomes 1A 2 2
MIRT574671 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT576699 Hps3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 2 2
MIRT607889 SATB1 SATB homeobox 1 2 2
MIRT608846 FGF14 fibroblast growth factor 14 2 6
MIRT608854 SPATA6 spermatogenesis associated 6 2 2
MIRT608879 CNTF ciliary neurotrophic factor 2 6
MIRT608899 ZNF860 zinc finger protein 860 2 2
MIRT608948 C12orf60 chromosome 12 open reading frame 60 2 2
MIRT609029 CDH6 cadherin 6 2 2
MIRT609063 LPP LIM domain containing preferred translocation partner in lipoma 2 4
MIRT612277 ZNF280B zinc finger protein 280B 2 2
MIRT612520 SEPT7 septin 7 2 2
MIRT617202 GREM1 gremlin 1, DAN family BMP antagonist 2 2
MIRT618700 KIF13A kinesin family member 13A 2 2
MIRT619141 AFF2 AF4/FMR2 family member 2 2 2
MIRT621071 RAB11FIP3 RAB11 family interacting protein 3 2 6
MIRT627811 PTCHD1 patched domain containing 1 2 4
MIRT641782 ZBTB20 zinc finger and BTB domain containing 20 2 2
MIRT657645 GPRC5A G protein-coupled receptor class C group 5 member A 2 2
MIRT669313 C16orf72 chromosome 16 open reading frame 72 2 2
MIRT674602 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 2
MIRT684064 CPPED1 calcineurin like phosphoesterase domain containing 1 2 2
MIRT685149 TACR3 tachykinin receptor 3 2 2
MIRT693446 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 2 2
MIRT693808 WDR3 WD repeat domain 3 2 2
MIRT703845 ETV3 ETS variant 3 2 2
MIRT707100 ZNF850 zinc finger protein 850 2 2
MIRT707375 SVIP small VCP interacting protein 2 2
MIRT707467 ROCK2 Rho associated coiled-coil containing protein kinase 2 2 2
MIRT707514 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT707542 ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif 9 2 2
MIRT707560 CLVS2 clavesin 2 2 2
MIRT708113 HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 2 2
MIRT708217 ADD2 adducin 2 2 2
MIRT710678 MX2 MX dynamin like GTPase 2 2 2
MIRT755898 ZFPM2-AS1 ZFPM2 antisense RNA 1 3 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-511-3p Doxorubicin 31703 NSC123127 approved resistant High Anaplastic Thyroid Cancer tissue
hsa-miR-511-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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