miRTarBase - #MIRT237116


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pre-miRNA Information
pre-miRNA hsa-mir-19b-2   
Genomic Coordinates chrX: 134169671 - 134169766
Synonyms MIRN19B2, miR-19b-2, MIR19B2
Description Homo sapiens miR-19b-2 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-19b-2-5p
Sequence 19| AGUUUUGCAGGUUUGCAUUUCA |40
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs747654746 3 dbSNP
rs778397250 5 dbSNP
rs754566533 6 dbSNP
rs749008511 12 dbSNP
rs779795647 17 dbSNP
rs755951722 18 dbSNP
rs193073651 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol P2RY1   
Synonyms P2Y1, SARCC
Description purinergic receptor P2Y1
Transcript NM_002563   
Expression
Putative miRNA Targets on P2RY1
3'UTR of P2RY1
(miRNA target sites are highlighted)		 
>P2RY1|NM_002563|3'UTR
   1 AGGCACAAGAATCTCCAAACACCTCTCTGTTGTAATATGGTAGGATGCTTAACAGAATCAAGTACTTTTCCCCTCTTTAA
  81 CTTTCTAGTTTAGAAAAAAATCAAACCAAGAAAATAGTGAGTTAAAAAAATAATAGAAGTAGAAATGCCCACATCCACAC
 161 TTAGCTTGTTTGGGTTTGCTTTCACAGTCTCTCTTCCTTCTGACTAGAAGTATGTATAATAAAACAATACTACCTAGTTA
 241 AACATTTACTTTCTCTTTTGCCTTTAAAATGTGCAGGCTTTTCTGTTTAAAGTGTGTGTGCACATGAGTACTGGGGCTGT
 321 TTTTGATATTAGTAATTTCTCTAAGAAAACTAGCCCCCTGCAACTTGAGTTTGTGGTTTATCTAGCCTTTATTGTTTTTT
 401 TAAAATCCACAGTAGGAATAAAAAATCTATATTCTCAGAAATATCTAGCATGGTATATAACAAAACACTAAACTCATCAG
 481 TTCATCCGGCATCAGATCAATGGATCTCTGAGCGGGGTGTTTTTTTCAGTGTCTTATAAGCATAGATGATAGTTGACTGA
 561 GTTTCTTTAGGGCATTGAATAGACAAGTAAAGCTAATGAATTTAAAAGCCTGAAAAGTGATTGTTTTCCAGTTATTTCTG
 641 GAAAAGGTCTCATTATATATTGGGTGCTAAATGTTTGATGGGGAAAGCCTGCATATATTATCGTACTGGTAAAATGCATT
 721 CAAAATAATTAAAGTGCATGTATTTTCCTTGTAAACACCATGAGCTCTCTTAGACATCTTGTGATAAAGAGCATTTACTT
 801 GCCCCACTGCTGTGCAATGCCTTAGGACTTTGTTTGTGTTCCAGGACAAGTGTTCACTCACATCTGTAAAAACAATTTTA
 881 AGAATTGCAAATAAATTACAGACCAAAGATTGAGTAAAGTCAAATAACTGTTAGTAAGTTGAAGGATATTGGACAGGAGG
 961 ACAGTATTTCAGAAAAGGAGAGGTTGACAGTCATCCACAAGGCATAGCCTCCAAGTATACTCTCAAATGTATGAAGCAAC
1041 TGGGGTGGGCAGAAGACATTTTAGAATGAGGGCTTTAGTTTAAATTAAAGTCATGGTGGAGAAGACTCTTGCTTCCTCCA
1121 AGTGTTTGAAAACACAAAATGCGATATGAAAAGAAGAAATAGAATTTGTATAGGTTGCATTGATAGAATGGGAAGCTATA
1201 ATCTTTGAATAAACCTTACATCTCAATATTTAAAGAAAAAACATATATATGGAGGGAAATATAGAGAATTAAAGTACCTA
1281 GATGCCATAGCACTGAAAAGTAAAGTACTACTCAAACTACTAATAGAAGACTATTGGTCAGTGTTTTCTATTATATTTGT
1361 TCTCTGCCAGGTGTTAATGAAAAATTTGTAAAATGCTTCAACAGTGTTAATAATTTTAATGAATATTGAATTGCTGCATG
1441 TCTAGTCCTTGAAATGGTCAAATTCTATATAATGAGAATAACAAGGTGAGATAATGCAATTGACAATCCCAAACAAATCC
1521 AGTGTCAAAGGAATTTTTAGTTTTGGAAGCTATCCCTCATAAAGTCAACATCAGAGTTTGCAACTGATGGTGGCATAACT
1601 TGTTTGAAAGCACTTTACAAGTAGAGCAACATGGGGCTGTATGTTAAGGCAAGAAAGAACCTTAGTGCCCCGTGGACCAT
1681 AATGACAGGAAATTTTCAGGTCTTGATTTCAGTTCTTGCAATGCCTATGTAGATTGAGGATTTGTGAGACCTTCAGAGTA
1761 GCTTCACTTTACCCAATCTCTGGCCACTAAGATCAATGAAGAAAAGCTGTATTTAACCTTCCAAAGCAGTGATTCTTTTT
1841 ACATGTTCAGTTTTAATGCATAGGATTATAGAAACCAAATCAAGAAGAAACCTACTACACCTCCTTATTTTGAGGAAAGA
1921 GAGGGTTAGCAAAGTTCTCACTTCATCAGGCTCAAATAACATCCGTTTTAGATTCCTACAAGACAAAATCTAAAATATGT
2001 CATTACTTTATTGACCTTGTTAAACAAGATCAATATCATTAAACTGACCAAGATGGAAATTACAGGACTTGTACCAGACT
2081 TGAACTTGTAGCCTAATGATACACATTTTTACAATATTTCTTCACCATTTAGTTTTCTTTCTTTTAGGTCTCAGGATGCT
2161 CAGCTTAATTTAGAGTATGTGTTAAGTACATTGTTTCAGCGTCCAGAGAATTTTGTGAGTGTGGATCCAGTGAGGAGGTG
2241 AACAGTAACTAGAAATGCTTGTTTACTACTTGGCATGTTTTTTCCAAAGTGTTTCTTCTTTAGCTTCATACATCACATAT
2321 GGACACTGATGACATGTGAATGCATGCCACATAGTAACAAGAATGATCTTGCCAACTCCTTCCAAGCCAAAAGAAGCCTC
2401 TGGGAAGGTGTGCCAATGGTGAAAACGTACAGAGGGTCAGGGTGAAGCAGTGATCTCTATTGGCTGAAAAACTGATCAGG
2481 TCATATGATGATTGAAGTATGTTTATTGTAAGGGCAGAAATGTGTTGGCATTTGGATAAAAAACTGCTAACATTATAGAA
2561 CTTATTACCTAACAAAATTTCACACCACAAAAAATATTTTAATGGCAAATTCAAGGTGTTTTATTGCTTACAAATCAGCA
2641 TCTTTGACTCTTTGAACATCAATTTGTGTTTACATTGAAATGACAAAAAGACAAACTAAGAAGAAATACAGCATGCAAGT
2721 TGGAATTCAGAGTTAAAACCATGATGTTGCCGCTCAGCCAGCTATGTGACTGTTGACCCTTTCAAGAACACACATGGATT
2801 TAAAAGTTGGATGACATCCATTGTTGGGGCCTTGGGGGATATGGTAAAGCATGAAAACTAAACAGCCAGGAGCCTGTGAA
2881 ATCTGCTACTGTATTTTCCAGGACTTCATTCCACTCCTTGGCTAAAAAAATCTTGGAAGTTTCACAGATTATGATGTGGA
2961 CCTGTCACCTGTAAATTGTCTCAATCTACTCAGACAAGACACTAAACTGTCTTTGGATACTATAGATGTCAGTGCTTATA
3041 GCAGCTGGAATTTGGCTAGTGACAATGTTTAAAGATGTAATACTAGTTAGTATCTATTGAAGCTTAAACTTTGCTGGTCA
3121 GGTTGTAGCTATTGTAAAAGTATTTATTGAAGAAGCTCACAGTCCTTCAGTTGTACAGACTGAAAAACTTTCATGAAAGA
3201 TCCAACATACTAATGTAAATTATATTTATTACAATGTATGATATTAATGTGTCAAACTGGTGTATTTTACAAAATATATA
3281 ATGCATACATAAATAAGAGTTGTATATTACAGTGCTTTTCAAATATCAGTGTCTTGGAATATTTAAGTCTTCACATTTTT
3361 TGGTCTAAAATATGAAAATGTTTCATGATACAAGTGATTAATTTTCCCTAGTAGTGCTTTTGCATGTTTGCCTTTTTATT
3441 TAAGTTTTTTTCTATATAGACACAATTTGGTGTCAGACTATCATAAGATCGATAGTGAATATAAAATATCTTAGCCAAAT
3521 GGGGTCTGTATTGTCTACATTTTATATATTAAATAAAAGTTTTTGTTGTCTTTTCAGGAGGTTTAGAGTATTGTCACTAA
3601 ATATGATCAAAGCTTCCCTTTCCAAATGCAAAAGTCTTGTCCTACATTTAAAGTTGATCTGTCATGTTTTAGCAGTCAAG
3681 TGGGATGGGCATTATATAAACAACGTTACAATGTAAGGAAAATCTTTAAGGAGATGGGGAGAGAAAAAGGCAGCTGGTAT
3761 AATCGGTTACTGCTGCTTAGTTCTACTTAATTTTTTGTGTTGCTTCTTCTTAAGGTGAGATAGCATAATCTTAACTGTTT
3841 TGAGATGGAATTTTAAAGTAACACACTACCAGCGAGTTCAACACTGCTATTGATTTTAATCTGTTTTTTTTTGTTTAGTT
3921 GATAACTTAAATTCCAAGTTTCATAGTGATAATTGTATATTATTTGGCTGCTGAATTCTGTTAGAGTTTTTTATTCTGTT
4001 GTACATTGTATTATACACATAATCACAAATTAATATGAAGGTGAATATATGTTACATATCAAAATTTGTGAATTTGAATT
4081 ATAGTATGTTTTAGTGCTATTGCAAAAAATGTTTATTTTTATATTATCTGTGATTTTAATATAGATGATTGAACTAGATT
4161 TCTTTTTGAGTGATAGTGCCATTGAATGAGCAGTATGGAAACAGTGTTACTTGATATTTTGAGCTTTCTCAGGTTTATCT
4241 AAATCAGTGGTAGCTTAACAAAACCCAGACTAATTGTGTGTAATTGTATTTTTAATAAAAGGAAAGTACATTTCCTATAA
4321 TAGCATAGTACTGTTTGCATGTAAGAGTATGCAAAACCTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTAGT
4401 GTGTGTAAGGCATGGCAGCCAACTTTGTATCTGCTATTTTTAGTACGAGCAGAGCTTCATAATTGTGGTCACTAGAACTG
4481 TACTTACCATGGACAGTTAAAACTGAAAAAGACTCAATAAAACTATGAAACATGGAAAAAAAAAAAAAAAAAAAAAAAAA
4561 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acuuUACGU--UUGGACGUUUUGa 5'
              |||:|  |:: |||||||| 
Target 5' ttgcATGTAAGAGTATGCAAAACc 3'
 4335 - 4358 160.00 -13.20
2 
miRNA  3' acuUUACGUUUGGACGUUUUga 5'
             |:||| |  :|||||||  
Target 5' tttAGTGCTA--TTGCAAAAaa 3'
 4090 - 4109 139.00 -10.90
3 
miRNA  3' acuUUAC-GUUUGGACGUUUUGa 5'
             ||||  |||::||:||||: 
Target 5' gttAATGAAAAATTTGTAAAATg 3'
 1373 - 1395 139.00 -9.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30510043 30 COSMIC
COSN30733288 37 COSMIC
COSN30496213 41 COSMIC
COSN15625634 45 COSMIC
COSN30698965 70 COSMIC
COSN509859 70 COSMIC
COSN26846337 75 COSMIC
COSN30154955 76 COSMIC
COSN29854178 82 COSMIC
COSN30142535 96 COSMIC
COSN31507172 107 COSMIC
COSN30130564 152 COSMIC
COSN28822178 154 COSMIC
COSN30526870 211 COSMIC
COSN31571997 223 COSMIC
COSN15665908 231 COSMIC
COSN30534740 249 COSMIC
COSN31608865 254 COSMIC
COSN28423606 311 COSMIC
COSN14041121 340 COSMIC
COSN31527779 348 COSMIC
COSN30534528 366 COSMIC
COSN30129041 398 COSMIC
COSN30684715 402 COSMIC
COSN30114327 435 COSMIC
COSN31517123 439 COSMIC
COSN30534858 461 COSMIC
COSN30129367 599 COSMIC
COSN30534522 620 COSMIC
COSN30114630 625 COSMIC
COSN22181863 665 COSMIC
COSN1921932 741 COSMIC
COSN19657930 742 COSMIC
COSN26958338 832 COSMIC
COSN6736716 864 COSMIC
COSN1921933 927 COSMIC
COSN31564735 950 COSMIC
COSN15865679 973 COSMIC
COSN30527807 1022 COSMIC
COSN26958339 1120 COSMIC
COSN15625635 1123 COSMIC
COSN30113999 1138 COSMIC
COSN30134561 1143 COSMIC
COSN17384043 1144 COSMIC
COSN31962178 1155 COSMIC
COSN6736717 1392 COSMIC
COSN25051402 1439 COSMIC
COSN27272448 1551 COSMIC
COSN4812536 1630 COSMIC
COSN8909482 1650 COSMIC
COSN9136797 1758 COSMIC
COSN20627564 2038 COSMIC
COSN5524037 2662 COSMIC
COSN9136799 2817 COSMIC
COSN16753682 3104 COSMIC
COSN17033269 3300 COSMIC
COSN9136800 3316 COSMIC
COSN1921934 3428 COSMIC
COSN6736718 3646 COSMIC
COSN29538346 3913 COSMIC
COSN26659560 4333 COSMIC
COSN19293906 4390 COSMIC
COSN23217168 4394 COSMIC
COSN27270822 4395 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs146412401 2 dbSNP
rs763198360 4 dbSNP
rs766534183 6 dbSNP
rs1205841602 9 dbSNP
rs1290900263 14 dbSNP
rs1025079638 17 dbSNP
rs144160018 19 dbSNP
rs1158348891 20 dbSNP
rs755868115 24 dbSNP
rs556696415 26 dbSNP
rs1455510078 30 dbSNP
rs757232502 36 dbSNP
rs1179207131 39 dbSNP
rs1365234735 42 dbSNP
rs778362503 46 dbSNP
rs1016391370 49 dbSNP
rs963076828 63 dbSNP
rs1182711731 65 dbSNP
rs1423008959 70 dbSNP
rs150595710 73 dbSNP
rs551364081 74 dbSNP
rs921876928 75 dbSNP
rs1243765864 78 dbSNP
rs553881995 81 dbSNP
rs542457320 82 dbSNP
rs1208655554 87 dbSNP
rs1040123518 92 dbSNP
rs1270550748 94 dbSNP
rs954593888 101 dbSNP
rs1443323129 105 dbSNP
rs901588184 107 dbSNP
rs1321454276 115 dbSNP
rs987344001 120 dbSNP
rs1397354797 124 dbSNP
rs993162182 124 dbSNP
rs1025982259 129 dbSNP
rs951766832 133 dbSNP
rs1471407885 134 dbSNP
rs1432242727 140 dbSNP
rs1268245392 151 dbSNP
rs559375082 152 dbSNP
rs1159778480 157 dbSNP
rs1457247292 169 dbSNP
rs1366452874 182 dbSNP
rs1005814056 188 dbSNP
rs1394507176 190 dbSNP
rs186675156 192 dbSNP
rs945837198 199 dbSNP
rs1463574997 216 dbSNP
rs1175729593 221 dbSNP
rs1206185793 227 dbSNP
rs1042480513 231 dbSNP
rs1263975573 235 dbSNP
rs1404173746 235 dbSNP
rs925336459 259 dbSNP
rs1017578967 272 dbSNP
rs1296393977 276 dbSNP
rs1225604450 278 dbSNP
rs969566408 279 dbSNP
rs369249803 285 dbSNP
rs1414812695 286 dbSNP
rs1327875284 288 dbSNP
rs769707716 288 dbSNP
rs1333915193 296 dbSNP
rs936698523 305 dbSNP
rs960781383 316 dbSNP
rs1055037030 317 dbSNP
rs879427511 330 dbSNP
rs1013787318 331 dbSNP
rs1046581491 332 dbSNP
rs886616034 334 dbSNP
rs1447755200 336 dbSNP
rs1231673562 342 dbSNP
rs1194518913 343 dbSNP
rs572886552 355 dbSNP
rs1212053125 356 dbSNP
rs73869849 358 dbSNP
rs1273511720 359 dbSNP
rs979392282 370 dbSNP
rs1016032345 376 dbSNP
rs564748189 378 dbSNP
rs910451612 395 dbSNP
rs1195599210 403 dbSNP
rs533618428 408 dbSNP
rs1271236488 410 dbSNP
rs963427765 415 dbSNP
rs995867793 417 dbSNP
rs757648018 418 dbSNP
rs550506762 430 dbSNP
rs1199797864 434 dbSNP
rs765745965 445 dbSNP
rs1372635962 449 dbSNP
rs772168502 456 dbSNP
rs1252497316 464 dbSNP
rs967256400 471 dbSNP
rs1376478969 474 dbSNP
rs901645267 479 dbSNP
rs750931023 484 dbSNP
rs1378440228 485 dbSNP
rs1047906118 487 dbSNP
rs1483871465 488 dbSNP
rs1273252051 490 dbSNP
rs564013034 491 dbSNP
rs887467809 501 dbSNP
rs868623970 503 dbSNP
rs1257712070 509 dbSNP
rs759012754 511 dbSNP
rs925418777 516 dbSNP
rs563647226 517 dbSNP
rs990818597 528 dbSNP
rs1394002626 532 dbSNP
rs1337800945 534 dbSNP
rs1329749841 536 dbSNP
rs530609243 537 dbSNP
rs1400101866 542 dbSNP
rs1174844145 543 dbSNP
rs1470552986 550 dbSNP
rs1411871807 558 dbSNP
rs1157482100 569 dbSNP
rs1473764417 572 dbSNP
rs1331915935 573 dbSNP
rs36108725 583 dbSNP
rs1393181666 585 dbSNP
rs1186339909 604 dbSNP
rs191831836 613 dbSNP
rs1440209374 616 dbSNP
rs1257575461 624 dbSNP
rs1203745375 628 dbSNP
rs7643597 636 dbSNP
rs1266138276 638 dbSNP
rs1230044349 639 dbSNP
rs566152258 646 dbSNP
rs1351084237 647 dbSNP
rs1046643682 673 dbSNP
rs528595421 674 dbSNP
rs1338860644 680 dbSNP
rs377156981 680 dbSNP
rs545813575 681 dbSNP
rs564191272 682 dbSNP
rs1268839920 686 dbSNP
rs1320415711 687 dbSNP
rs1219858075 696 dbSNP
rs1409096689 699 dbSNP
rs1162288102 703 dbSNP
rs751013162 704 dbSNP
rs1369821966 706 dbSNP
rs1183716761 712 dbSNP
rs898956578 718 dbSNP
rs995920104 720 dbSNP
rs1210462562 725 dbSNP
rs1467482439 728 dbSNP
rs1028714119 739 dbSNP
rs879171661 740 dbSNP
rs773733252 743 dbSNP
rs1447380242 752 dbSNP
rs1288803648 756 dbSNP
rs16864613 760 dbSNP
rs567126484 761 dbSNP
rs567248586 765 dbSNP
rs1317398478 770 dbSNP
rs776561008 773 dbSNP
rs747843116 775 dbSNP
rs1246857632 778 dbSNP
rs1364497626 793 dbSNP
rs1319143493 798 dbSNP
rs1433417314 801 dbSNP
rs184913427 803 dbSNP
rs967687537 805 dbSNP
rs1403928364 808 dbSNP
rs978640316 812 dbSNP
rs552907168 818 dbSNP
rs374021448 829 dbSNP
rs1448376018 831 dbSNP
rs763989584 837 dbSNP
rs139453601 839 dbSNP
rs1190442755 840 dbSNP
rs943292314 844 dbSNP
rs544780022 848 dbSNP
rs923120122 860 dbSNP
rs1453086444 861 dbSNP
rs929106705 876 dbSNP
rs1223428878 886 dbSNP
rs1294801615 894 dbSNP
rs1047496417 898 dbSNP
rs1216389990 901 dbSNP
rs1363327922 908 dbSNP
rs1274740993 909 dbSNP
rs1434797281 926 dbSNP
rs1347716178 928 dbSNP
rs1303396922 950 dbSNP
rs1428635365 953 dbSNP
rs558488751 963 dbSNP
rs189756957 979 dbSNP
rs1044083996 984 dbSNP
rs1424424456 988 dbSNP
rs544272151 1018 dbSNP
rs982489769 1019 dbSNP
rs1481309067 1020 dbSNP
rs1002466364 1025 dbSNP
rs563950005 1029 dbSNP
rs1181181310 1033 dbSNP
rs1482885161 1038 dbSNP
rs1488679824 1041 dbSNP
rs908145906 1050 dbSNP
rs940939333 1052 dbSNP
rs1037910175 1059 dbSNP
rs1206760065 1064 dbSNP
rs1308107802 1065 dbSNP
rs1278561613 1067 dbSNP
rs1217922222 1069 dbSNP
rs774322898 1071 dbSNP
rs1284407458 1074 dbSNP
rs1409590598 1084 dbSNP
rs1348296084 1086 dbSNP
rs1010132573 1087 dbSNP
rs1333382358 1094 dbSNP
rs1247567604 1095 dbSNP
rs1358024973 1103 dbSNP
rs749165269 1106 dbSNP
rs529651786 1107 dbSNP
rs899341093 1112 dbSNP
rs770846877 1113 dbSNP
rs1266159233 1122 dbSNP
rs1350002951 1125 dbSNP
rs1050192115 1143 dbSNP
rs1021068098 1144 dbSNP
rs1158210094 1146 dbSNP
rs1471467937 1150 dbSNP
rs968530111 1163 dbSNP
rs890181391 1165 dbSNP
rs1000917673 1171 dbSNP
rs543202874 1172 dbSNP
rs1020351331 1174 dbSNP
rs1208108903 1176 dbSNP
rs1326357802 1187 dbSNP
rs1192722913 1188 dbSNP
rs1228208284 1191 dbSNP
rs1308727988 1197 dbSNP
rs375733063 1197 dbSNP
rs1223939854 1198 dbSNP
rs1377981888 1199 dbSNP
rs1300627163 1204 dbSNP
rs1488706642 1207 dbSNP
rs1406787131 1210 dbSNP
rs1319755906 1226 dbSNP
rs1455460801 1233 dbSNP
rs975988633 1236 dbSNP
rs903139313 1244 dbSNP
rs1419972503 1245 dbSNP
rs1413335843 1246 dbSNP
rs1181879881 1250 dbSNP
rs559719971 1252 dbSNP
rs1000511844 1260 dbSNP
rs1032894011 1263 dbSNP
rs950607974 1264 dbSNP
rs73020228 1265 dbSNP
rs991257108 1270 dbSNP
rs561914979 1276 dbSNP
rs1023686464 1279 dbSNP
rs551573250 1281 dbSNP
rs181890255 1287 dbSNP
rs1166796105 1290 dbSNP
rs115692369 1291 dbSNP
rs982176643 1302 dbSNP
rs377085239 1309 dbSNP
rs1247570051 1313 dbSNP
rs1432723805 1316 dbSNP
rs550593615 1316 dbSNP
rs1387046214 1324 dbSNP
rs1156242078 1329 dbSNP
rs1362071965 1332 dbSNP
rs907861603 1334 dbSNP
rs868264483 1335 dbSNP
rs1044136251 1340 dbSNP
rs760771753 1342 dbSNP
rs962038147 1346 dbSNP
rs938305550 1349 dbSNP
rs760910886 1350 dbSNP
rs896718759 1351 dbSNP
rs920824273 1354 dbSNP
rs1314057164 1359 dbSNP
rs1335305562 1360 dbSNP
rs534383970 1363 dbSNP
rs1288167604 1364 dbSNP
rs1042948333 1368 dbSNP
rs1289164390 1372 dbSNP
rs529140464 1374 dbSNP
rs114070051 1385 dbSNP
rs1359538236 1385 dbSNP
rs911667384 1391 dbSNP
rs1224600370 1398 dbSNP
rs1328183572 1402 dbSNP
rs944450846 1405 dbSNP
rs1386039411 1412 dbSNP
rs1041417073 1417 dbSNP
rs1017618625 1432 dbSNP
rs1301540214 1434 dbSNP
rs1426715862 1439 dbSNP
rs902855094 1444 dbSNP
rs964704640 1449 dbSNP
rs997457436 1477 dbSNP
rs776971035 1479 dbSNP
rs1460502079 1488 dbSNP
rs1375317238 1490 dbSNP
rs1194452245 1491 dbSNP
rs762167966 1492 dbSNP
rs1267127239 1499 dbSNP
rs185239116 1500 dbSNP
rs1256794868 1504 dbSNP
rs894366218 1505 dbSNP
rs1030279802 1515 dbSNP
rs950686779 1522 dbSNP
rs536177789 1550 dbSNP
rs1251840290 1552 dbSNP
rs547502025 1553 dbSNP
rs1232370651 1555 dbSNP
rs983351609 1556 dbSNP
rs189352335 1557 dbSNP
rs963215207 1559 dbSNP
rs1172592540 1561 dbSNP
rs1346430618 1565 dbSNP
rs563280411 1571 dbSNP
rs566556102 1584 dbSNP
rs149676622 1585 dbSNP
rs1014972050 1588 dbSNP
rs1168999807 1593 dbSNP
rs750739951 1596 dbSNP
rs938357821 1598 dbSNP
rs1303726375 1599 dbSNP
rs558683540 1603 dbSNP
rs1056809961 1605 dbSNP
rs1373253267 1606 dbSNP
rs1390127277 1613 dbSNP
rs1480952532 1615 dbSNP
rs1250661436 1632 dbSNP
rs918214942 1637 dbSNP
rs1377710961 1639 dbSNP
rs1233931562 1651 dbSNP
rs945626854 1672 dbSNP
rs962372576 1673 dbSNP
rs1264891956 1674 dbSNP
rs763229972 1678 dbSNP
rs1256332591 1680 dbSNP
rs1279198724 1686 dbSNP
rs973400875 1693 dbSNP
rs181736680 1706 dbSNP
rs1042616181 1715 dbSNP
rs1329686228 1716 dbSNP
rs1196654763 1721 dbSNP
rs544212292 1722 dbSNP
rs1404588536 1725 dbSNP
rs1339225260 1728 dbSNP
rs1470522629 1730 dbSNP
rs1411616787 1732 dbSNP
rs1156451809 1733 dbSNP
rs114599885 1735 dbSNP
rs538653674 1739 dbSNP
rs1364008628 1748 dbSNP
rs1186275354 1751 dbSNP
rs1442196126 1761 dbSNP
rs1244917243 1767 dbSNP
rs752027748 1773 dbSNP
rs1439765555 1776 dbSNP
rs1464273812 1777 dbSNP
rs12497578 1781 dbSNP
rs542957191 1786 dbSNP
rs1353167784 1790 dbSNP
rs1434471024 1793 dbSNP
rs115814854 1797 dbSNP
rs1354261740 1799 dbSNP
rs1464564762 1800 dbSNP
rs1380617061 1810 dbSNP
rs1041859795 1811 dbSNP
rs1401199667 1819 dbSNP
rs924359944 1820 dbSNP
rs1345113836 1822 dbSNP
rs1316757368 1824 dbSNP
rs1402770072 1833 dbSNP
rs1385258322 1841 dbSNP
rs1440281783 1845 dbSNP
rs1162225170 1846 dbSNP
rs1442248996 1851 dbSNP
rs1386488362 1857 dbSNP
rs1448848574 1862 dbSNP
rs1240260650 1863 dbSNP
rs1291793078 1875 dbSNP
rs1370042096 1876 dbSNP
rs1219989790 1881 dbSNP
rs1301782010 1882 dbSNP
rs935676780 1887 dbSNP
rs1054033729 1893 dbSNP
rs1447324204 1895 dbSNP
rs1285247650 1896 dbSNP
rs894418435 1897 dbSNP
rs1221950918 1903 dbSNP
rs1357381016 1908 dbSNP
rs1012780461 1917 dbSNP
rs1030748653 1918 dbSNP
rs1246790988 1918 dbSNP
rs575971478 1919 dbSNP
rs1045592563 1922 dbSNP
rs563484134 1934 dbSNP
rs1361931214 1946 dbSNP
rs1306675957 1951 dbSNP
rs907034726 1955 dbSNP
rs886409792 1960 dbSNP
rs1004028246 1962 dbSNP
rs528673675 1965 dbSNP
rs1367036793 1966 dbSNP
rs1422434728 1966 dbSNP
rs1005223768 1969 dbSNP
rs1015436993 1970 dbSNP
rs962140366 1977 dbSNP
rs1216789347 2003 dbSNP
rs1169528545 2008 dbSNP
rs1475626857 2012 dbSNP
rs995270458 2015 dbSNP
rs185168732 2019 dbSNP
rs755818293 2024 dbSNP
rs963232422 2041 dbSNP
rs1489938551 2047 dbSNP
rs1271294927 2065 dbSNP
rs979920199 2085 dbSNP
rs1306938166 2086 dbSNP
rs1458110809 2090 dbSNP
rs1212519987 2094 dbSNP
rs777419962 2097 dbSNP
rs1216764474 2107 dbSNP
rs986389698 2113 dbSNP
rs959775280 2122 dbSNP
rs1347050483 2137 dbSNP
rs1303341692 2138 dbSNP
rs992538097 2150 dbSNP
rs536950697 2154 dbSNP
rs1172451743 2157 dbSNP
rs565020267 2158 dbSNP
rs1410533968 2159 dbSNP
rs1428506181 2166 dbSNP
rs1174062539 2167 dbSNP
rs1481279392 2172 dbSNP
rs1191389657 2178 dbSNP
rs189591594 2180 dbSNP
rs966628960 2181 dbSNP
rs1477039515 2190 dbSNP
rs376770804 2191 dbSNP
rs924383248 2198 dbSNP
rs1206701554 2201 dbSNP
rs180842900 2202 dbSNP
rs1263028397 2205 dbSNP
rs1222096911 2220 dbSNP
rs1326041190 2221 dbSNP
rs1283545340 2223 dbSNP
rs186480982 2225 dbSNP
rs764503223 2226 dbSNP
rs1299445659 2232 dbSNP
rs915588494 2236 dbSNP
rs936874120 2245 dbSNP
rs1470839809 2248 dbSNP
rs948353422 2250 dbSNP
rs1045643046 2252 dbSNP
rs1158092127 2259 dbSNP
rs1418778947 2269 dbSNP
rs907091056 2271 dbSNP
rs1437511510 2276 dbSNP
rs1179065493 2278 dbSNP
rs78414640 2280 dbSNP
rs1243097281 2285 dbSNP
rs1036848245 2287 dbSNP
rs897944138 2288 dbSNP
rs1339657281 2290 dbSNP
rs770666880 2296 dbSNP
rs1051830326 2299 dbSNP
rs573494550 2306 dbSNP
rs1215507491 2315 dbSNP
rs546569299 2316 dbSNP
rs1004869208 2326 dbSNP
rs373648445 2334 dbSNP
rs1318550903 2351 dbSNP
rs745843297 2369 dbSNP
rs538433966 2376 dbSNP
rs1381323838 2379 dbSNP
rs11300426 2386 dbSNP
rs1454574937 2387 dbSNP
rs1383416742 2389 dbSNP
rs571017174 2391 dbSNP
rs768825626 2393 dbSNP
rs568942014 2403 dbSNP
rs1221931479 2412 dbSNP
rs1019625699 2418 dbSNP
rs537963932 2422 dbSNP
rs1034187610 2427 dbSNP
rs554559339 2428 dbSNP
rs1161491498 2434 dbSNP
rs966305787 2441 dbSNP
rs1181822775 2449 dbSNP
rs1487066622 2452 dbSNP
rs978013641 2455 dbSNP
rs574361272 2460 dbSNP
rs1257458168 2461 dbSNP
rs1186343564 2463 dbSNP
rs1020012897 2475 dbSNP
rs1262134376 2491 dbSNP
rs145510307 2493 dbSNP
rs978441672 2499 dbSNP
rs1289026455 2514 dbSNP
rs553367379 2516 dbSNP
rs1294719225 2523 dbSNP
rs1380334430 2529 dbSNP
rs1363743452 2539 dbSNP
rs1290861975 2544 dbSNP
rs573512220 2550 dbSNP
rs989863832 2555 dbSNP
rs1365176278 2557 dbSNP
rs1161809730 2561 dbSNP
rs545160756 2564 dbSNP
rs1369583902 2566 dbSNP
rs547575475 2574 dbSNP
rs1427111084 2576 dbSNP
rs1264376337 2584 dbSNP
rs1194824661 2589 dbSNP
rs948405347 2589 dbSNP
rs1266286727 2598 dbSNP
rs981060961 2600 dbSNP
rs1224110467 2605 dbSNP
rs928566958 2617 dbSNP
rs1158403021 2619 dbSNP
rs1250702969 2623 dbSNP
rs1358862277 2629 dbSNP
rs1225067467 2643 dbSNP
rs939951880 2649 dbSNP
rs1299830880 2651 dbSNP
rs1037308120 2662 dbSNP
rs1222651804 2663 dbSNP
rs922119481 2663 dbSNP
rs1301486127 2668 dbSNP
rs1447249533 2668 dbSNP
rs1282351296 2670 dbSNP
rs376102398 2672 dbSNP
rs1406872132 2687 dbSNP
rs898335374 2691 dbSNP
rs1391452373 2695 dbSNP
rs1381184555 2699 dbSNP
rs145261194 2708 dbSNP
rs191409160 2710 dbSNP
rs1049191900 2714 dbSNP
rs940721891 2717 dbSNP
rs889175462 2718 dbSNP
rs899125620 2722 dbSNP
rs1451681567 2732 dbSNP
rs1218319206 2746 dbSNP
rs1287244411 2752 dbSNP
rs1193557292 2753 dbSNP
rs1292149937 2758 dbSNP
rs1485548425 2764 dbSNP
rs1007592351 2776 dbSNP
rs538533890 2778 dbSNP
rs1186125543 2779 dbSNP
rs141231258 2782 dbSNP
rs1365460302 2789 dbSNP
rs540356444 2790 dbSNP
rs1321091090 2795 dbSNP
rs1014074961 2811 dbSNP
rs145510034 2814 dbSNP
rs999107290 2816 dbSNP
rs369674347 2821 dbSNP
rs796990567 2821 dbSNP
rs1032645042 2824 dbSNP
rs963650730 2825 dbSNP
rs1032302932 2830 dbSNP
rs561086047 2837 dbSNP
rs1469622248 2839 dbSNP
rs377686937 2842 dbSNP
rs1179027999 2849 dbSNP
rs1011674887 2850 dbSNP
rs1022701111 2852 dbSNP
rs969761679 2853 dbSNP
rs981554202 2858 dbSNP
rs770073108 2860 dbSNP
rs961298306 2863 dbSNP
rs565407113 2866 dbSNP
rs1264834074 2867 dbSNP
rs1063103 2868 dbSNP
rs919814088 2870 dbSNP
rs940788486 2871 dbSNP
rs1237001622 2873 dbSNP
rs1448605942 2875 dbSNP
rs931147102 2877 dbSNP
rs1379131814 2878 dbSNP
rs1373976958 2891 dbSNP
rs1049573960 2892 dbSNP
rs910660700 2905 dbSNP
rs1381212025 2914 dbSNP
rs1241959093 2924 dbSNP
rs920612715 2925 dbSNP
rs1383833746 2929 dbSNP
rs183606838 2929 dbSNP
rs560173252 2931 dbSNP
rs187386914 2933 dbSNP
rs1040809051 2936 dbSNP
rs1055748448 2937 dbSNP
rs1454907912 2942 dbSNP
rs368834073 2943 dbSNP
rs530659631 2943 dbSNP
rs1182425883 2945 dbSNP
rs1281114668 2948 dbSNP
rs763328618 2949 dbSNP
rs766701981 2950 dbSNP
rs1053388820 2961 dbSNP
rs1221638137 2967 dbSNP
rs893378731 2969 dbSNP
rs1011724273 2972 dbSNP
rs1023087306 2978 dbSNP
rs1441615983 2983 dbSNP
rs1179557827 2985 dbSNP
rs553820768 3001 dbSNP
rs1283842172 3016 dbSNP
rs969815635 3023 dbSNP
rs999960054 3036 dbSNP
rs1286904677 3040 dbSNP
rs1245310667 3044 dbSNP
rs16864614 3054 dbSNP
rs1477141298 3060 dbSNP
rs569080051 3063 dbSNP
rs537902414 3066 dbSNP
rs1326159405 3068 dbSNP
rs1426982343 3077 dbSNP
rs1315796520 3078 dbSNP
rs562551992 3079 dbSNP
rs568173712 3081 dbSNP
rs1397575194 3102 dbSNP
rs1162417985 3104 dbSNP
rs1422169399 3105 dbSNP
rs1387036516 3110 dbSNP
rs751877773 3110 dbSNP
rs1163710220 3114 dbSNP
rs1448376256 3122 dbSNP
rs961089107 3123 dbSNP
rs972780853 3135 dbSNP
rs1240208006 3143 dbSNP
rs779538160 3148 dbSNP
rs1489422236 3156 dbSNP
rs1029236201 3157 dbSNP
rs1221884275 3165 dbSNP
rs1489867004 3182 dbSNP
rs1277020852 3184 dbSNP
rs1229330476 3193 dbSNP
rs954981680 3194 dbSNP
rs988089357 3196 dbSNP
rs1346113618 3199 dbSNP
rs919869390 3204 dbSNP
rs1340774888 3211 dbSNP
rs1302084185 3215 dbSNP
rs1402571357 3216 dbSNP
rs908044904 3225 dbSNP
rs75494987 3226 dbSNP
rs1323640037 3229 dbSNP
rs79675874 3229 dbSNP
rs1409362451 3233 dbSNP
rs962494760 3235 dbSNP
rs952587182 3237 dbSNP
rs985328050 3239 dbSNP
rs1172607740 3242 dbSNP
rs533537464 3248 dbSNP
rs1459436281 3250 dbSNP
rs1424636372 3263 dbSNP
rs1199386220 3289 dbSNP
rs1489882335 3290 dbSNP
rs1490139399 3294 dbSNP
rs77419830 3305 dbSNP
rs1222387535 3306 dbSNP
rs1437797455 3313 dbSNP
rs1271450506 3315 dbSNP
rs1200937399 3330 dbSNP
rs1040481672 3337 dbSNP
rs923323521 3340 dbSNP
rs573427023 3347 dbSNP
rs1248315585 3350 dbSNP
rs991484741 3358 dbSNP
rs1440793720 3359 dbSNP
rs917196417 3368 dbSNP
rs950003088 3372 dbSNP
rs1465960418 3373 dbSNP
rs1405001399 3378 dbSNP
rs1173988974 3380 dbSNP
rs1431723095 3381 dbSNP
rs558133167 3387 dbSNP
rs1421398853 3389 dbSNP
rs1191873887 3392 dbSNP
rs1469645706 3409 dbSNP
rs1053513238 3423 dbSNP
rs893429453 3424 dbSNP
rs1180978988 3431 dbSNP
rs947632807 3432 dbSNP
rs759003712 3434 dbSNP
rs780855946 3435 dbSNP
rs1467080971 3439 dbSNP
rs1202145311 3442 dbSNP
rs1044592979 3452 dbSNP
rs1313630940 3453 dbSNP
rs1170791964 3455 dbSNP
rs147723456 3456 dbSNP
rs1370467819 3470 dbSNP
rs903032873 3491 dbSNP
rs1447515067 3492 dbSNP
rs1003429056 3494 dbSNP
rs548886325 3500 dbSNP
rs896884264 3501 dbSNP
rs1467349851 3504 dbSNP
rs1361134310 3506 dbSNP
rs1176982057 3507 dbSNP
rs560712312 3507 dbSNP
rs575422778 3515 dbSNP
rs1399792328 3522 dbSNP
rs1378616184 3523 dbSNP
rs865819975 3524 dbSNP
rs1276656698 3525 dbSNP
rs899586239 3531 dbSNP
rs952639714 3541 dbSNP
rs1243038693 3545 dbSNP
rs1320654853 3556 dbSNP
rs1029287036 3558 dbSNP
rs890754133 3561 dbSNP
rs2579134 3562 dbSNP
rs1237710486 3571 dbSNP
rs1009166533 3597 dbSNP
rs1354333998 3611 dbSNP
rs1314763185 3613 dbSNP
rs544451106 3617 dbSNP
rs1268337291 3634 dbSNP
rs1358676435 3637 dbSNP
rs576718692 3645 dbSNP
rs1312765360 3647 dbSNP
rs1397574431 3656 dbSNP
rs1379535972 3662 dbSNP
rs561204415 3666 dbSNP
rs55857160 3673 dbSNP
rs1288067597 3677 dbSNP
rs965255359 3685 dbSNP
rs1430347352 3699 dbSNP
rs1358835227 3704 dbSNP
rs976980397 3705 dbSNP
rs1488049446 3706 dbSNP
rs1385183535 3710 dbSNP
rs923405530 3719 dbSNP
rs1192704015 3727 dbSNP
rs962264556 3728 dbSNP
rs934738614 3731 dbSNP
rs1027779850 3735 dbSNP
rs1478788159 3740 dbSNP
rs1193766578 3750 dbSNP
rs988806001 3754 dbSNP
rs574911651 3757 dbSNP
rs142610068 3760 dbSNP
rs947350939 3765 dbSNP
rs560558475 3766 dbSNP
rs1391007033 3767 dbSNP
rs906095601 3777 dbSNP
rs1246986511 3786 dbSNP
rs550246188 3791 dbSNP
rs938892082 3794 dbSNP
rs1342739337 3797 dbSNP
rs1057478955 3798 dbSNP
rs747918284 3803 dbSNP
rs896939633 3806 dbSNP
rs1212555072 3817 dbSNP
rs1338754588 3820 dbSNP
rs1300223420 3839 dbSNP
rs1312620666 3843 dbSNP
rs35048787 3845 dbSNP
rs1339168240 3854 dbSNP
rs1364968702 3854 dbSNP
rs1291857281 3858 dbSNP
rs777728979 3860 dbSNP
rs1350956263 3867 dbSNP
rs950067533 3874 dbSNP
rs977391097 3875 dbSNP
rs994312261 3883 dbSNP
rs1193844503 3887 dbSNP
rs924511788 3904 dbSNP
rs935873782 3904 dbSNP
rs1026699945 3905 dbSNP
rs1054217402 3913 dbSNP
rs1488788859 3913 dbSNP
rs1283666954 3914 dbSNP
rs1489145649 3918 dbSNP
rs1205703895 3919 dbSNP
rs1255402230 3922 dbSNP
rs1280343520 3923 dbSNP
rs888113665 3923 dbSNP
rs1189047395 3927 dbSNP
rs1385289853 3933 dbSNP
rs1345106599 3946 dbSNP
rs1299349672 3950 dbSNP
rs1388564908 3951 dbSNP
rs1438742401 3953 dbSNP
rs932410866 3956 dbSNP
rs61115581 3958 dbSNP
rs1464394637 3965 dbSNP
rs890815297 3970 dbSNP
rs1469012026 3983 dbSNP
rs1375540394 3986 dbSNP
rs183262118 3990 dbSNP
rs143383110 3999 dbSNP
rs976654455 4003 dbSNP
rs1176628334 4004 dbSNP
rs1459032347 4006 dbSNP
rs1258537859 4009 dbSNP
rs1202775708 4018 dbSNP
rs1344633533 4019 dbSNP
rs1031245215 4020 dbSNP
rs528301995 4027 dbSNP
rs1414717050 4050 dbSNP
rs1027830575 4057 dbSNP
rs958829416 4067 dbSNP
rs1331681888 4071 dbSNP
rs1308618494 4082 dbSNP
rs1445288710 4083 dbSNP
rs956533158 4086 dbSNP
rs991587880 4087 dbSNP
rs1332509291 4089 dbSNP
rs988859796 4095 dbSNP
rs868278981 4100 dbSNP
rs1399639160 4104 dbSNP
rs2290916 4108 dbSNP
rs115871709 4109 dbSNP
rs971452788 4119 dbSNP
rs927591532 4123 dbSNP
rs1156292531 4129 dbSNP
rs1376208552 4132 dbSNP
rs1238684869 4133 dbSNP
rs568026906 4140 dbSNP
rs571364331 4142 dbSNP
rs938927471 4148 dbSNP
rs866141514 4154 dbSNP
rs977819217 4168 dbSNP
rs1254337021 4184 dbSNP
rs1057332432 4192 dbSNP
rs1345957531 4203 dbSNP
rs918756843 4203 dbSNP
rs140441973 4213 dbSNP
rs1354608029 4215 dbSNP
rs1356504424 4218 dbSNP
rs1216242998 4225 dbSNP
rs1310568055 4225 dbSNP
rs1447780089 4234 dbSNP
rs547031074 4247 dbSNP
rs570436082 4248 dbSNP
rs1048187058 4251 dbSNP
rs1255154855 4270 dbSNP
rs888185753 4271 dbSNP
rs1006587332 4274 dbSNP
rs1359477844 4287 dbSNP
rs1295857836 4288 dbSNP
rs1420948465 4298 dbSNP
rs73020230 4318 dbSNP
rs932464669 4325 dbSNP
rs558820777 4328 dbSNP
rs1187970934 4333 dbSNP
rs912289050 4334 dbSNP
rs569238597 4351 dbSNP
rs1262685460 4352 dbSNP
rs1214586166 4353 dbSNP
rs998519165 4355 dbSNP
rs879255845 4358 dbSNP
rs1400115927 4359 dbSNP
rs1425810419 4359 dbSNP
rs1491269019 4359 dbSNP
rs1030879991 4360 dbSNP
rs1162002878 4360 dbSNP
rs1191704476 4360 dbSNP
rs1220888823 4360 dbSNP
rs1264077437 4360 dbSNP
rs1423187646 4360 dbSNP
rs1478917442 4360 dbSNP
rs56261476 4360 dbSNP
rs67012448 4360 dbSNP
rs72359384 4360 dbSNP
rs773329517 4360 dbSNP
rs774455005 4360 dbSNP
rs1292583928 4361 dbSNP
rs1450441889 4361 dbSNP
rs774597739 4361 dbSNP
rs796259710 4361 dbSNP
rs898126930 4361 dbSNP
rs1220163214 4362 dbSNP
rs1243293832 4363 dbSNP
rs956765748 4372 dbSNP
rs1010665843 4376 dbSNP
rs1273786539 4382 dbSNP
rs1433617805 4392 dbSNP
rs1456920887 4392 dbSNP
rs796320689 4394 dbSNP
rs1021692614 4396 dbSNP
rs1464919991 4399 dbSNP
rs1176175368 4400 dbSNP
rs1397917712 4420 dbSNP
rs1172547039 4426 dbSNP
rs1381787521 4427 dbSNP
rs968755309 4432 dbSNP
rs980111356 4445 dbSNP
rs927275536 4446 dbSNP
rs150415535 4447 dbSNP
rs555160580 4448 dbSNP
rs1248966679 4454 dbSNP
rs1200122025 4456 dbSNP
rs918821299 4462 dbSNP
rs1376256642 4465 dbSNP
rs759650568 4465 dbSNP
rs562566140 4469 dbSNP
rs1200890403 4478 dbSNP
rs538367853 4486 dbSNP
rs138272761 4492 dbSNP
rs1277432289 4496 dbSNP
rs1346436865 4506 dbSNP
rs1399721366 4506 dbSNP
rs1274912047 4512 dbSNP
rs778614332 4517 dbSNP
rs909674100 4518 dbSNP
rs1333175383 4524 dbSNP
rs1447182118 4526 dbSNP
rs1355366525 4527 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000305097.3 | 3UTR | ACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000305097.3 | 3UTR | ACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000305097.3 | 3UTR | AACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000305097.3 | 3UTR | AAACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000305097.3 | 3UTR | AACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000305097.3 | 3UTR | AAACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000305097.3 | 3UTR | AACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000305097.3 | 3UTR | AACCUUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000305097.3 | 3UTR | AAAACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000305097.3 | 3UTR | AACCUUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000305097.3 | 3UTR | AACCUUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000305097.3 | 3UTR | ACCUUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000305097.3 | 3UTR | AAAACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000305097.3 | 3UTR | AACCUUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 15 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000305097.3 | 3UTR | AAGAGUAUGCAAAACCUUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 16 for dataset GSM1084077
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SigmaAb
Location of target site ENST00000305097.3 | 3UTR | AAACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 17 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000305097.3 | 3UTR | AAACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 18 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000305097.3 | 3UTR | ACCUUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 19 for dataset GSM1013116
Method / RBP HITS-CLIP  / AGO
Cell line / Condition hMSC / hMSC-replicate-5
Location of target site ENST00000305097.3 | 3UTR | AACCUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24038734 / GSE41272
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.864 7.0e-5 -0.775 9.3e-4 13 Click to see details
GSE28544 Breast cancer 0.648 3.1e-4 0.639 3.9e-4 24 Click to see details
GSE17498 Multiple myeloma 0.327 2.0e-2 -0.005 4.9e-1 40 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.394 2.6e-2 0.338 4.9e-2 25 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.202 1.7e-1 0.414 2.0e-2 25 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.292 2.2e-1 -0.333 1.9e-1 9 Click to see details
GSE42095 Differentiated embryonic stem cells 0.16 2.3e-1 -0.043 4.2e-1 23 Click to see details
GSE19350 CNS germ cell tumors -0.22 2.5e-1 0.042 4.5e-1 12 Click to see details
GSE21687 Ependynoma primary tumors -0.071 2.9e-1 -0.023 4.3e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.108 3.3e-1 -0.469 1.8e-2 20 Click to see details
GSE38226 Liver fibrosis 0.093 3.4e-1 -0.001 5.0e-1 21 Click to see details
GSE32688 Pancreatic cancer 0.055 3.8e-1 -0.116 2.6e-1 32 Click to see details
GSE26953 Aortic valvular endothelial cells -0.056 4.0e-1 -0.109 3.1e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
-0.056 4.0e-1 -0.109 3.1e-1 24 Click to see details
-0.056 4.0e-1 -0.109 3.1e-1 24 Click to see details
93 hsa-miR-19b-2-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT063866 RASSF8 Ras association domain family member 8 2 6
MIRT077658 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT078463 MAP3K3 mitogen-activated protein kinase kinase kinase 3 2 2
MIRT095250 FAM13B family with sequence similarity 13 member B 2 2
MIRT109492 KLHL15 kelch like family member 15 2 6
MIRT155380 CCNT2 cyclin T2 2 2
MIRT163210 EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 2 2
MIRT188328 ARID1A AT-rich interaction domain 1A 2 2
MIRT204725 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT236401 HMGXB4 HMG-box containing 4 2 2
MIRT237116 P2RY1 purinergic receptor P2Y1 2 5
MIRT286944 SOCS7 suppressor of cytokine signaling 7 2 2
MIRT438799 MYC MYC proto-oncogene, bHLH transcription factor 1 1
MIRT442521 MOB3B MOB kinase activator 3B 2 2
MIRT452256 RPL30 ribosomal protein L30 2 2
MIRT473426 MDM4 MDM4, p53 regulator 2 2
MIRT476781 FOS Fos proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT476940 FAM83G family with sequence similarity 83 member G 2 2
MIRT480182 CALM2 calmodulin 2 2 6
MIRT489618 ZNF384 zinc finger protein 384 2 2
MIRT492244 SLC39A9 solute carrier family 39 member 9 2 2
MIRT492420 RGL2 ral guanine nucleotide dissociation stimulator like 2 2 2
MIRT494858 ZNF99 zinc finger protein 99 2 2
MIRT496999 SNAP25 synaptosome associated protein 25 2 2
MIRT501971 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT504915 CD38 CD38 molecule 2 4
MIRT507017 HMGA2 high mobility group AT-hook 2 2 6
MIRT510818 SBNO1 strawberry notch homolog 1 2 4
MIRT514164 PGPEP1 pyroglutamyl-peptidase I 2 2
MIRT514326 PSMG2 proteasome assembly chaperone 2 2 4
MIRT514427 SLC38A7 solute carrier family 38 member 7 2 2
MIRT514534 ESR2 estrogen receptor 2 2 2
MIRT516115 SRPX2 sushi repeat containing protein, X-linked 2 2 4
MIRT517757 ZNF366 zinc finger protein 366 2 4
MIRT518493 FAM161B family with sequence similarity 161 member B 2 4
MIRT518510 CASP10 caspase 10 2 2
MIRT518559 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT518639 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT518727 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT523562 GGCX gamma-glutamyl carboxylase 2 4
MIRT526521 YIPF6 Yip1 domain family member 6 2 2
MIRT530252 ZNF620 zinc finger protein 620 2 2
MIRT531656 ZFP14 ZFP14 zinc finger protein 2 2
MIRT532697 TCN2 transcobalamin 2 2 4
MIRT534017 STXBP4 syntaxin binding protein 4 2 2
MIRT535746 MYO10 myosin X 2 4
MIRT544507 GTF2E2 general transcription factor IIE subunit 2 2 2
MIRT546756 RLIM ring finger protein, LIM domain interacting 2 2
MIRT547927 HNRNPR heterogeneous nuclear ribonucleoprotein R 2 2
MIRT550128 ZNF138 zinc finger protein 138 2 2
MIRT551761 MED21 mediator complex subunit 21 2 2
MIRT557725 FYCO1 FYVE and coiled-coil domain containing 1 2 2
MIRT558922 CBX1 chromobox 1 2 2
MIRT562464 CORO1C coronin 1C 2 2
MIRT562757 ZNF846 zinc finger protein 846 2 2
MIRT563059 ZNF28 zinc finger protein 28 2 2
MIRT563334 RPLP0 ribosomal protein lateral stalk subunit P0 2 2
MIRT569168 DMD dystrophin 2 2
MIRT573253 TNFAIP6 TNF alpha induced protein 6 2 2
MIRT575055 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 4
MIRT575358 Zxda zinc finger, X-linked, duplicated A 2 2
MIRT613231 CCDC39 coiled-coil domain containing 39 2 2
MIRT613345 ADRBK2 G protein-coupled receptor kinase 3 2 6
MIRT613950 TMEM59 transmembrane protein 59 2 2
MIRT615486 EDN1 endothelin 1 2 2
MIRT618708 ESD esterase D 2 2
MIRT630607 ARHGAP1 Rho GTPase activating protein 1 2 2
MIRT630617 CXCR6 C-X-C motif chemokine receptor 6 2 2
MIRT630629 IMPAD1 inositol monophosphatase domain containing 1 2 2
MIRT630672 KLF7 Kruppel like factor 7 2 2
MIRT630744 COG6 component of oligomeric golgi complex 6 2 2
MIRT636851 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT638640 GPATCH8 G-patch domain containing 8 2 2
MIRT639104 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT639420 PKP1 plakophilin 1 2 2
MIRT640185 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT641755 SF3A1 splicing factor 3a subunit 1 2 2
MIRT666575 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT672164 FANCF Fanconi anemia complementation group F 2 2
MIRT688343 ETS1 ETS proto-oncogene 1, transcription factor 2 2
MIRT690118 ZFAND1 zinc finger AN1-type containing 1 2 2
MIRT696937 CERK ceramide kinase 2 2
MIRT701359 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT703286 GID4 GID complex subunit 4 homolog 2 2
MIRT709144 ZNF799 zinc finger protein 799 2 2
MIRT710846 FAM210A family with sequence similarity 210 member A 2 2
MIRT712619 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT714589 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT716907 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT721163 FAM200B family with sequence similarity 200 member B 2 2
MIRT722401 BCAS2 BCAS2, pre-mRNA processing factor 2 2
MIRT722515 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT724597 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-19b-2 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-miR-19b-2-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-19b-2-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-19b-2-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-19b-2-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-19b-2-5p Tamoxifen 2733525 NSC180973 approved resistant cell line (TamR4)
hsa-miR-19b-2-5p Tamoxifen 2733525 NSC180973 approved resistant cell line (TamR8)
hsa-miR-19b-2-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-19b-2-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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