miRTarBase - #MIRT238900


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pre-miRNA Information
pre-miRNA hsa-mir-4703   
Genomic Coordinates chr13: 51552589 - 51552667
Description Homo sapiens miR-4703 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4703-3p
Sequence 49| UGUAGUUGUAUUGUAUUGCCAC |70
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1460841833 5 dbSNP
rs775733304 5 dbSNP
rs756076492 10 dbSNP
rs1378936855 11 dbSNP
rs1049480258 12 dbSNP
rs555347919 13 dbSNP
rs1343138432 18 dbSNP
rs1011011214 19 dbSNP
rs1008216326 21 dbSNP
rs1238676458 22 dbSNP
Putative Targets

Gene Information
Gene Symbol PEX3   
Synonyms PBD10A, PBD10B, TRG18
Description peroxisomal biogenesis factor 3
Transcript NM_003630   
Expression
Putative miRNA Targets on PEX3
3'UTR of PEX3
(miRNA target sites are highlighted)		 
>PEX3|NM_003630|3'UTR
   1 TTTTTCCTTCAAGAAAAACTACAGTGGGATTCATTTACTTTTTAAAATACACTGGGTAAATCACCTATACTTAGAGTAAC
  81 AGTTTGTTATCAAAATGCCTGATAAAATATATTCTTAATAAAAGTCTTCATTTCATAATGAAATCAATTTATTTGGCATC
 161 TTAATATATTTTTTTAGATTCATCAACAGACCAGTTTTTGTGGGCATATATATATACACGTGCAAATATCAGAATTGTTA
 241 ATAATTTGTTACACATGGACATTTGTTCCAAACTGACTAAAAATCAATATAGATATTTTATATACATATATATATATAAA
 321 AATACAAAATTCAGTGTACTTTACCATATTAATACTGAGGAAAAATCTGTTGGAGACATAGGTCTAGGATGTGTGAAGTT
 401 TGGAAAAATATGCTATTTAATTATAATGTTCCCTAGACTGCTGTAAACAGAAGTGAATCAGACTTTTCTCCAGCTACCTT
 481 TCAAAATAATAAATTATTTGTCTCAAATATACCTTGATGGAGGACTTTTTTATTCTTATGGAAATAGTGAATTCCAACAA
 561 CTATGATGAACTATGTTCTTTGCTATTTCTTCACTATATTTTTTAAGGTTTTATTAAAAAGCCTTAGAAAGTTACATATT
 641 GGTTTAGAGGCTAAAATTGTGTTGATGCTGTTTACTCACCTAATTACATAGTTTTAATCATTTGTACATAATTTTAAAAA
 721 CTTACTTTGTATTGATTTTGAATACAGTGAAAATCTTATTGCAATAAACTATTTTAGTAAAATATTATTTTGTTGAGTTA
 801 ATATTTTTCAGCTATTAATTTACTTATCCCATAGCATTTTTGTTATTATTTCGGAAGAGAGAGCATGCTAGTTTAAGTTT
 881 CATTTTAATTGGTCGTGTACTTGGTGCTTTTTTGTTGTTGTTAACTTGTTCATTTAGTAAAAAGCAAATAGCTTTACTTT
 961 CTGAAAAAGAAATAATTCATTATCTCTAGTAATACATCTGTAATTCTTCATTTAGAAGGGTAATTAGGGCAAAAGTAAAT
1041 AAATCATTATATATCATTAGTATGTTGACATATATTTTCAGTAACATTGTTTTATGTTCCTCCAGCGTAACATGTAGCTG
1121 AACAGTAGAAGGTAGAAAATAAATTATGACATCTCTTCTAAGGCCTGGCTAGGCCTGAAGCTCACTGCCAGGGAGTTTGT
1201 GTCTAGAATGTTTTTAAAAATAGGTAGTGGAGCCATAGCCCTCACCATAGACACCTCTGAGCCCACTGGCATTGTCTCTG
1281 AGCAGAAGATGGCTGTGCCACTCACATATGCTAATCTTGGCAAATCTGCCAAGCATGTCTTCACCAAGGGATATGGATTT
1361 GGCTTAATAAAACCTGATTTGAAAACAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' caCCGUUAU--GUUA----UGUUGAUGu 5'
            || ||||   |||    |||||||: 
Target 5' atGGAAATAGTGAATTCCAACAACTATg 3'
 538 - 565 144.00 -9.20
2 
miRNA  3' caCCGUUAUGUUAUGUUGAUGu 5'
            | :||||:  | ||:|||: 
Target 5' gaGTTAATATTTTTCAGCTATt 3'
 795 - 816 128.00 -8.70
3 
miRNA  3' caccguuauguuAUGUUGAUGu 5'
                      | ||:|||| 
Target 5' atcagacttttcTCCAGCTACc 3'
 457 - 478 126.00 -5.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
355578 130 ClinVar
907774 206 ClinVar
355579 221 ClinVar
904445 288 ClinVar
355580 306 ClinVar
355581 318 ClinVar
355582 320 ClinVar
904446 322 ClinVar
904447 378 ClinVar
355583 392 ClinVar
355584 425 ClinVar
355585 547 ClinVar
355586 574 ClinVar
355587 678 ClinVar
905239 709 ClinVar
905240 743 ClinVar
355588 794 ClinVar
905241 823 ClinVar
355589 896 ClinVar
355590 959 ClinVar
906831 979 ClinVar
906832 986 ClinVar
355591 1075 ClinVar
906833 1227 ClinVar
355592 1306 ClinVar
355593 1333 ClinVar
355594 1336 ClinVar
COSN30744579 13 COSMIC
COSN30126574 21 COSMIC
COSN30102549 33 COSMIC
COSN28864484 176 COSMIC
COSN23825617 517 COSMIC
COSN26255621 776 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759900100 11 dbSNP
rs1163362345 15 dbSNP
rs772218196 17 dbSNP
rs775827622 19 dbSNP
rs866418203 23 dbSNP
rs984738368 25 dbSNP
rs760791128 26 dbSNP
rs1289484285 35 dbSNP
rs1016195612 42 dbSNP
rs1352891310 44 dbSNP
rs1236895928 46 dbSNP
rs1276304191 47 dbSNP
rs1259771626 84 dbSNP
rs935693157 86 dbSNP
rs1184667913 87 dbSNP
rs1486809223 90 dbSNP
rs1286392907 93 dbSNP
rs989897638 104 dbSNP
rs1221442430 112 dbSNP
rs1357094307 125 dbSNP
rs964944950 125 dbSNP
rs41285017 130 dbSNP
rs923472286 136 dbSNP
rs111975241 150 dbSNP
rs986983719 152 dbSNP
rs1341671061 155 dbSNP
rs535705746 156 dbSNP
rs1303154090 164 dbSNP
rs1403462007 168 dbSNP
rs1324205642 169 dbSNP
rs1367905703 169 dbSNP
rs1379308306 174 dbSNP
rs1242067680 177 dbSNP
rs932465315 178 dbSNP
rs751903695 187 dbSNP
rs945082165 191 dbSNP
rs184104448 192 dbSNP
rs1050881940 201 dbSNP
rs1489787755 206 dbSNP
rs78091135 206 dbSNP
rs903485626 206 dbSNP
rs1269222974 209 dbSNP
rs937911657 211 dbSNP
rs939930992 213 dbSNP
rs1267117576 216 dbSNP
rs1228970887 220 dbSNP
rs117247312 221 dbSNP
rs558770232 222 dbSNP
rs1403664075 227 dbSNP
rs1347729936 229 dbSNP
rs1250761653 235 dbSNP
rs1324622778 247 dbSNP
rs995939004 248 dbSNP
rs577296854 251 dbSNP
rs1033725346 253 dbSNP
rs1026841911 256 dbSNP
rs541024354 257 dbSNP
rs895198627 259 dbSNP
rs1428739628 263 dbSNP
rs1458777636 272 dbSNP
rs1013634794 274 dbSNP
rs1479431482 276 dbSNP
rs1379082817 280 dbSNP
rs779692327 288 dbSNP
rs1437089216 289 dbSNP
rs1247945356 292 dbSNP
rs1380035791 295 dbSNP
rs1006235183 303 dbSNP
rs1457783662 305 dbSNP
rs1222146604 306 dbSNP
rs1326299129 306 dbSNP
rs1417673602 306 dbSNP
rs886061133 306 dbSNP
rs1167589099 307 dbSNP
rs1016226935 308 dbSNP
rs559362259 309 dbSNP
rs1238774858 318 dbSNP
rs771525459 318 dbSNP
rs886061134 318 dbSNP
rs1491519968 319 dbSNP
rs1420511276 320 dbSNP
rs223234 320 dbSNP
rs1030569248 322 dbSNP
rs966870186 347 dbSNP
rs1447742619 357 dbSNP
rs1330894903 361 dbSNP
rs989010328 363 dbSNP
rs1372407490 374 dbSNP
rs1389445643 379 dbSNP
rs1173132583 387 dbSNP
rs978350257 391 dbSNP
rs140007169 392 dbSNP
rs1322180487 397 dbSNP
rs945114617 409 dbSNP
rs1180082798 414 dbSNP
rs189379544 425 dbSNP
rs990262195 428 dbSNP
rs1232168732 444 dbSNP
rs1241924263 449 dbSNP
rs1201215089 455 dbSNP
rs1443707789 468 dbSNP
rs920933577 469 dbSNP
rs932355581 470 dbSNP
rs1205108872 477 dbSNP
rs1270683359 479 dbSNP
rs1311954347 482 dbSNP
rs986560090 483 dbSNP
rs1382323252 497 dbSNP
rs1198931750 507 dbSNP
rs1055483297 509 dbSNP
rs1454620527 539 dbSNP
rs1341200429 540 dbSNP
rs565839917 545 dbSNP
rs939871043 546 dbSNP
rs10809 547 dbSNP
rs898438221 549 dbSNP
rs1423689815 551 dbSNP
rs1420141397 552 dbSNP
rs1384215556 562 dbSNP
rs192220670 564 dbSNP
rs1473480669 572 dbSNP
rs886061135 574 dbSNP
rs1425921931 575 dbSNP
rs1445777254 586 dbSNP
rs886239441 590 dbSNP
rs1217807036 593 dbSNP
rs1359229498 596 dbSNP
rs1289840547 601 dbSNP
rs1230266304 605 dbSNP
rs1357096689 610 dbSNP
rs1269678148 616 dbSNP
rs1343800446 617 dbSNP
rs895166088 623 dbSNP
rs1300031059 651 dbSNP
rs1400347784 656 dbSNP
rs1170303902 657 dbSNP
rs1013602225 667 dbSNP
rs1161229747 668 dbSNP
rs570448931 675 dbSNP
rs886061136 678 dbSNP
rs902668042 683 dbSNP
rs1460277933 689 dbSNP
rs528056082 700 dbSNP
rs1037741567 706 dbSNP
rs1265937682 711 dbSNP
rs1195097651 718 dbSNP
rs559454565 720 dbSNP
rs1267254121 727 dbSNP
rs1223967169 732 dbSNP
rs184546017 748 dbSNP
rs1452421311 753 dbSNP
rs1272640167 760 dbSNP
rs1212877089 761 dbSNP
rs546726053 762 dbSNP
rs118145502 765 dbSNP
rs1219196326 770 dbSNP
rs996115440 772 dbSNP
rs1291331693 780 dbSNP
rs1291572832 792 dbSNP
rs958493154 793 dbSNP
rs535466526 794 dbSNP
rs1350092237 825 dbSNP
rs1327819842 830 dbSNP
rs1341889067 834 dbSNP
rs1407694071 847 dbSNP
rs1027963066 853 dbSNP
rs190231974 854 dbSNP
rs1480399593 855 dbSNP
rs986528817 862 dbSNP
rs1193274994 864 dbSNP
rs1489050506 865 dbSNP
rs569167875 866 dbSNP
rs1232485798 869 dbSNP
rs1202752163 872 dbSNP
rs954994782 880 dbSNP
rs1010869117 881 dbSNP
rs1199115392 894 dbSNP
rs142265611 895 dbSNP
rs3804545 896 dbSNP
rs1220731945 898 dbSNP
rs1212708377 908 dbSNP
rs1278545150 908 dbSNP
rs961227193 911 dbSNP
rs1444169932 912 dbSNP
rs1256914052 921 dbSNP
rs1331457783 922 dbSNP
rs1020453056 923 dbSNP
rs532988782 933 dbSNP
rs1178921918 937 dbSNP
rs979211866 953 dbSNP
rs925013150 957 dbSNP
rs1175660915 958 dbSNP
rs41285019 959 dbSNP
rs368301467 970 dbSNP
rs544996656 970 dbSNP
rs919780195 973 dbSNP
rs1460087845 974 dbSNP
rs777447974 979 dbSNP
rs780264866 985 dbSNP
rs1212183517 986 dbSNP
rs931196852 990 dbSNP
rs1283303618 1007 dbSNP
rs1478225422 1016 dbSNP
rs1378638383 1017 dbSNP
rs1309620115 1020 dbSNP
rs1054986804 1036 dbSNP
rs541087748 1051 dbSNP
rs1376400999 1052 dbSNP
rs1305057147 1057 dbSNP
rs553070296 1075 dbSNP
rs1467030420 1089 dbSNP
rs949417170 1097 dbSNP
rs1417650007 1098 dbSNP
rs574455895 1107 dbSNP
rs902636844 1108 dbSNP
rs1381143826 1113 dbSNP
rs541853125 1115 dbSNP
rs907746296 1134 dbSNP
rs866608899 1147 dbSNP
rs1258394264 1148 dbSNP
rs1183461137 1151 dbSNP
rs1483547086 1186 dbSNP
rs1311055017 1188 dbSNP
rs1241503967 1190 dbSNP
rs1214172993 1202 dbSNP
rs1355638678 1203 dbSNP
rs1362373258 1219 dbSNP
rs999619029 1227 dbSNP
rs1054329920 1244 dbSNP
rs941854164 1246 dbSNP
rs893986918 1247 dbSNP
rs1244815686 1248 dbSNP
rs996406337 1258 dbSNP
rs1314254069 1260 dbSNP
rs1397062766 1265 dbSNP
rs1037774071 1275 dbSNP
rs140498068 1289 dbSNP
rs953678604 1291 dbSNP
rs531284480 1295 dbSNP
rs886061137 1306 dbSNP
rs1359467264 1307 dbSNP
rs1220635967 1309 dbSNP
rs181936427 1312 dbSNP
rs1370213155 1319 dbSNP
rs1051777768 1328 dbSNP
rs1428065033 1329 dbSNP
rs1422795784 1330 dbSNP
rs886061138 1333 dbSNP
rs9403495 1336 dbSNP
rs1221188529 1348 dbSNP
rs1263669919 1348 dbSNP
rs890411393 1354 dbSNP
rs1288786130 1361 dbSNP
rs1010526057 1363 dbSNP
rs1306451842 1378 dbSNP
rs972525089 1380 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' caccGUUAUGUUAUGUUGAUGu 5'
              ||| | ||   |||||| 
Target 5' ---uCAAGA-AA---AACUACa 3'
 		1 - 15
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000367591.4 | 3UTR | UCAAGAAAAACUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000367591.4 | 3UTR | UCAAGAAAAACUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
42 hsa-miR-4703-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT072026 SCP2 sterol carrier protein 2 2 2
MIRT079071 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT106648 PLEKHF2 pleckstrin homology and FYVE domain containing 2 2 4
MIRT178174 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT190328 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT230081 SH3BGRL SH3 domain binding glutamate rich protein like 2 2
MIRT238900 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT473705 MAPK1 mitogen-activated protein kinase 1 2 6
MIRT481891 ANKRD46 ankyrin repeat domain 46 2 4
MIRT483743 ALDH9A1 aldehyde dehydrogenase 9 family member A1 2 2
MIRT488823 MRRF mitochondrial ribosome recycling factor 2 2
MIRT488990 SLC28A1 solute carrier family 28 member 1 2 2
MIRT504173 FAM127B retrotransposon Gag like 8A 2 2
MIRT524461 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT529787 AP4S1 adaptor related protein complex 4 sigma 1 subunit 2 2
MIRT546449 SLC9A7 solute carrier family 9 member A7 2 2
MIRT547827 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 4
MIRT561462 TCERG1 transcription elongation regulator 1 2 2
MIRT562315 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT563644 ZNF675 zinc finger protein 675 2 2
MIRT563741 ZNF107 zinc finger protein 107 2 4
MIRT568318 BACH1 BTB domain and CNC homolog 1 2 2
MIRT571528 ZNF367 zinc finger protein 367 2 2
MIRT574840 CADM1 cell adhesion molecule 1 2 2
MIRT612262 MNT MAX network transcriptional repressor 2 4
MIRT622234 SLC25A45 solute carrier family 25 member 45 2 2
MIRT625372 IRGQ immunity related GTPase Q 2 2
MIRT628260 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT631738 NKX2-1 NK2 homeobox 1 2 2
MIRT646103 GORAB golgin, RAB6 interacting 2 2
MIRT647768 AMOTL1 angiomotin like 1 2 2
MIRT654309 RBMS3 RNA binding motif single stranded interacting protein 3 2 2
MIRT654988 PLCG2 phospholipase C gamma 2 2 2
MIRT659715 CCDC93 coiled-coil domain containing 93 2 2
MIRT666976 PHAX phosphorylated adaptor for RNA export 2 2
MIRT683247 WFDC6 WAP four-disulfide core domain 6 2 2
MIRT688424 DNAL1 dynein axonemal light chain 1 2 2
MIRT691896 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT701616 MYO1B myosin IB 2 2
MIRT702141 MAP3K1 mitogen-activated protein kinase kinase kinase 1 2 2
MIRT704403 CTPS1 CTP synthase 1 2 2
MIRT719515 RAB10 RAB10, member RAS oncogene family 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4703 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4703-3p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4703-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4703-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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