miRTarBase - #MIRT241949


—
pre-miRNA Information
pre-miRNA hsa-mir-2681   
Genomic Coordinates chr13: 101967642 - 101967746
Description Homo sapiens miR-2681 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2681-5p
Sequence 22| GUUUUACCACCUCCAGGAGACU |43
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 6 13 - 101967720 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1263364397 4 dbSNP
rs1184634146 7 dbSNP
rs1464264801 10 dbSNP
rs1173765682 11 dbSNP
rs1263470724 12 dbSNP
rs906180025 15 dbSNP
rs935390707 20 dbSNP
rs1045157564 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol BTG1   
Synonyms APRO2
Description BTG anti-proliferation factor 1
Transcript NM_001731   
Expression
Putative miRNA Targets on BTG1
3'UTR of BTG1
(miRNA target sites are highlighted)		 
>BTG1|NM_001731|3'UTR
   1 GATATAGTCTGTGGATGGATCATCTGATGATGATGGATAAATTTGATTTTTGCTTTGGGTGGGCTCCTCTTGGGGATGGA
  81 TTATGGAATTTAAACCATGTCACAGCTGTGAAGATCTGGCACAAGATAGAATGGTAAAAAAAAAAAAAATTTTAAGTGAC
 161 AGTGCCATAGTTTGGACAGTACCTTTCAATGATTAATTTTAATAGCCTGTGAGTCCAAGTAAATGATCACTTTATTTGCT
 241 AGGGAGGGAAGTCCTAGGGTGGTTTCAGTTTCTCCCAGACATACCTAAATTTTTACATCAATCCTTTTAAAGAAAATCTG
 321 TATTTCAAAGAATCTTTCTCTGCAGTAAATCTCGCAGGGGAATTTGCACTATTACACTTGAAAGTTGTTATTGTTAACCT
 401 TTTCGGCAGCTTTTAATAGGAAAGTTAAACGTTTTAAACATGGTAGTACTGGAAATTTTACAAGACTTTTACCTAGCACT
 481 TAAATATGTATAAATGTACATAAAGACAAACTAGTAAGCATGACCTGGGGAAATGGTCAGACCTTGTATTGTGTTTTTGG
 561 CCTTGAAAGTAGCAAGTGACCAGAATCTGCCATGGCAACAGGCTTTAAAAAAGACCCTTAAAAAGACACTGTCTCAACTG
 641 TGGTGTTAGCACCAGCCAGCTCTCTGTACATTTGCTAGCTTGTAGTTTTCTAAGACTGAGTAAACTTCTTATTTTTAGAA
 721 AGTGGAGGTCTGGTTTGTAACTTTCCTTGTACTTAATTGGGTAAAAGTCTTTTCCACAAACCACCATCTATTTTGTGAAC
 801 TTTGTTAGTCATCTTTTATTTGGTAAATTATGAACTGGTGTAAATTTGTACAGTTCATGTATATTGATTGTGGCAAAGTT
 881 GTACAGATTTCTATATTTTGGATGAGAAATTTTTCTTCTCTCTATAATAAATCGTTTCTTATCTTGGCATTTTAATCAAT
 961 CTCTTGTCATGATTATAGAGGTTTAGCTAAAAGTATTTTTTCTTAGAAGACAGGTTCTATAAACTGAATCTCTGTTGCAC
1041 ACTGGTCATGCTGGAAAAACATTTGATGAGGAATGAAGATGCTCTGTATATACATGTTTAGGTTTTACAGGAAACACAGG
1121 AGTAGCATGTTTTAAAAATTTCTAAAGTCAAAACATGGACACATTCACAGGCTAATGATCTCATGAAATAAGGATAAGAG
1201 ACCACGGTAGCATCTACCAAAAATGTGATACTCAAAGGATTACATTTCATTGCTTCCCTGTTGAAGTGAAGATATAAATG
1281 TTCCATTCTGACCCACCTTTGAAAAACAATTACTTTGCCCCATGGATTCTTTGTTCAATTAGAAATTTCCCCGGGGCAGG
1361 TGACCCATAGTCTTAAAGAACAGGCTAAACACCACAGAGAGATTGGTTGCTTTTTGCTTTTCATCACCTGCAAGATGTAC
1441 ATAAAAATCACATAAGCTGGAATTCAACAAAAGGTATGTTTATGAACTTTTATTCTCAAAAGTTGAAATGCTGACTTTCT
1521 CGATTCCTCATTTTCAGACTTTTATTTCAGATAAATACTAAAAACCTAAGTGAACCTTGATAATGCTGTAGTGTAGATTA
1601 CTTCACTACCCCATATAATAGAAGGACTTGCTGTTTAGTTGTAGAGGATAACAGCGTTTTTCAGTGGAAATTGAAAGTGG
1681 AAAAATTGAATTTTGCTCTACACAGTTAACATATAGTGGCCTTTTTTTGGTATATATGTAAACATGTTGACACTGGAAAT
1761 ACGCAGTCTGAAATAAAATTAGTAATTACTTGAAATTAGTAATCTCAAATAACTTTTAAGAAGTTATTTCTACACCCAGG
1841 AATAAATTATTCTGATTTTGTAGACAACACAGGAATAGGCCACTGAATATGCAGGTATTTAGAGTACAAATGTCTGTGGA
1921 TATTATTGGCACACCATTCTCGAGAGTTAGAATTCGTAGACCCGCAACACATGGACTACCCTTGCCAATTGTTATGGTTT
2001 TATTTTTAAACCTATTCTGTGAAAAAGCTCCTCGGTATTTCAAACTTGAATTACAATAAAAACACCAGGTAGGGTTGTTT
2081 TTAAATGGGTCTCACCCCAGTGCTGACTACTGTTGTTTACCAACTACATTTCATCTGGTAACTCCATTGAAACTAAGTAC
2161 CTCAACCATTTTTTTTTTTTATCATAAAGCCTTTTTTCAAATGGAAAGTTGTTTTTGAAGATCTTGACATCAGACTTTTT
2241 CAATCTTTGAAAATGATGGAAACAGTTAATAAAAATGTTTATTTTAGAATTCAGGTGATGTCTGGCTTGTGAGGAGCTGT
2321 TTATAAGTTTGTCTTTGAAAAAGGCTTGCACACATCACTCTGAGACCAGCTGTTTCCTGTGACTTTAACCTTACCTTCCC
2401 CAGACAATTGAGCTGAACCTGTATCTGCGGTACAGTAGCTGTTTGTGATGTATTTCTTGTTCACTGTTTCTGGGGAATGT
2481 TTTGAAATATTTTATTATAAATCCTTTTAAGATAGGATGACTACTTTCAAAATTATTGTTGCCTTTGGCACCAGGAATTC
2561 ATAGTTGTGATTGGCAGTAAGTTTGAGGAGTGTTACTTTCTAAGTTTTAACAGGTAGTTTTGAAATTATTTCCTTTTTTC
2641 CAAATTTAAGTAGTGCCTCCCTCTGTAATGTTGAAACAAGGCTTCAAGTGGATTGTATAGCAAGAGTTACCCTGGTTCAT
2721 GCAGGATAATGCGGCTGTTATCTTTGTCATCTGGAATGGGAATCTCATGTCTTTATCCTTATGTGCAATATTTCTATAAT
2801 AATAGACTGGAAAGGCCACCAGAAAGTGGCTTTCAGGTACATTGCACAAATAGTTTCCTTAAGTCATTATAACTCACACA
2881 TTGCAAGTAATTAATTTTGTTTTGTATAGGTGTTGCAGTTTATGAAATTGGCCTTCAAGTTAAAAGGAAGGAAGCCGTAT
2961 TCCCGATGGCTAGTGTTTAATGACTACAGGTTTCCAGGCTCCCTTTAATCTTGGGAGCAAATAAATCTACTATTGGACTT
3041 CTCCCTGCGTGACTTTTAACATTTCTGATACTCTCTCTTCTTCCTCTTTACAGAAGAGAGGTATGATAACTGAAGTTGTA
3121 CTTTGCATATTGAAGTTTAAAGATACTTCCTCTCCCCTTTTCACCCCTATTTCAAATGATGTGATAAAATCCTCTTGATA
3201 GGCTATATGGAGAACATTTGTCAATAGTTTTATCTATGCATGGAAGTCTTCAAAAAGTATATCTTGGATTGTCTAAAACT
3281 GAATAGATTTCTTATTTATCTGAAGGTATACAGACTGCCAACATTTTAGACTTATCTCTCAGTCTCTGCCACTGAACTTT
3361 TATATATGGCTGCTATCAAAATATAACCGGTTTATTTTCATATTTGGAACTAATATAACAGTATCACAAAATCTTTTACA
3441 GTAAGATAGTTTGTAATACCAGCCGACCCAGCTGCTTAACTGAGTCCTTAAATCATTTAATATATGGGACTGTAAATAGA
3521 GAAATCTGTACATTATGAGATCTGATTTCTGGTTATGCCTATAGATCTTTATTTTCTTTATCCCTATAGATCATTTTCTT
3601 CTGATGTTAAGTGTTATATTTTTGAAATGCTCCTAAACAAGTAAGCCTTAGATTGTATTAATCCTGAGGATTGATACCAT
3681 TTCCTCAACACTTTGTGGAGTATGATTGACACCAGTTTTTTTTTGACTGCAGGTTTAACTTGGCTTATCACTTTTCGTAT
3761 TGCTCAGTATGTCCAAGATAGGAATAAAAAAATGTAGTTCAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucAGAGGACC-----UCCA-CCAUUUUg 5'
            |:|||| |     |  | ||||||| 
Target 5' acTTTCCTTGTACTTAATTGGGTAAAAg 3'
 740 - 767 148.00 -7.94
2 
miRNA  3' ucagaggACCUCCACCAUUUUg 5'
                 | ||  |||||||| 
Target 5' cacaagaTAGA-ATGGTAAAAa 3'
 120 - 140 146.00 -6.90
3 
miRNA  3' ucAG-AGGACCUCCACCAUUUug 5'
            || ||:|  |  |||||||  
Target 5' agTCATCTTTTATTTGGTAAAtt 3'
 807 - 829 136.00 -10.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26649616 9 COSMIC
COSN26439020 16 COSMIC
COSN25147787 36 COSMIC
COSN26968166 55 COSMIC
COSN24304251 106 COSMIC
COSN20109958 135 COSMIC
COSN19660743 136 COSMIC
COSN29110820 149 COSMIC
COSN31585766 151 COSMIC
COSN25094850 165 COSMIC
COSN30534120 167 COSMIC
COSN5870919 202 COSMIC
COSN8586905 257 COSMIC
COSN5870918 349 COSMIC
COSN30173142 380 COSMIC
COSN8542456 489 COSMIC
COSN8542455 491 COSMIC
COSN26563534 599 COSMIC
COSN31609317 613 COSMIC
COSN31517746 718 COSMIC
COSN25627130 763 COSMIC
COSN15110386 767 COSMIC
COSN31538225 860 COSMIC
COSN27111513 873 COSMIC
COSN27115848 874 COSMIC
COSN31530211 906 COSMIC
COSN9482608 938 COSMIC
COSN22262349 1009 COSMIC
COSN27969393 1043 COSMIC
COSN26459740 1244 COSMIC
COSN1593857 1356 COSMIC
COSN5870917 1934 COSMIC
COSN1593856 2021 COSMIC
COSN23987729 2147 COSMIC
COSN22360298 2168 COSMIC
COSN27434477 2169 COSMIC
COSN20092622 2174 COSMIC
COSN15661524 3043 COSMIC
COSN32138715 3183 COSMIC
COSN26236457 3192 COSMIC
COSN1593855 3223 COSMIC
COSN22702287 3298 COSMIC
COSN1593854 3361 COSMIC
COSN26107383 3383 COSMIC
COSN1593853 3702 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs761235514 1 dbSNP
rs1423347633 2 dbSNP
rs764927448 4 dbSNP
rs372772364 5 dbSNP
rs753654285 6 dbSNP
rs28399543 10 dbSNP
rs759740821 15 dbSNP
rs775431387 18 dbSNP
rs1051046710 22 dbSNP
rs774562072 26 dbSNP
rs753507443 27 dbSNP
rs14991 28 dbSNP
rs374718903 30 dbSNP
rs372627397 34 dbSNP
rs763959550 36 dbSNP
rs770029415 37 dbSNP
rs1365100867 40 dbSNP
rs1188247562 45 dbSNP
rs28399544 46 dbSNP
rs1287427018 49 dbSNP
rs573266885 53 dbSNP
rs1216181900 55 dbSNP
rs1257998640 57 dbSNP
rs11554835 59 dbSNP
rs941072756 66 dbSNP
rs553227765 85 dbSNP
rs533954463 88 dbSNP
rs908316900 92 dbSNP
rs1245309675 95 dbSNP
rs982883075 97 dbSNP
rs971617886 105 dbSNP
rs917470660 106 dbSNP
rs145813706 112 dbSNP
rs1169985671 114 dbSNP
rs1422869945 115 dbSNP
rs1331116394 122 dbSNP
rs1447889503 125 dbSNP
rs1402899307 126 dbSNP
rs557589838 127 dbSNP
rs1404966604 129 dbSNP
rs1391598159 132 dbSNP
rs991795041 132 dbSNP
rs959222249 133 dbSNP
rs1289094799 136 dbSNP
rs202212514 136 dbSNP
rs1032974086 141 dbSNP
rs1397620199 149 dbSNP
rs11377023 150 dbSNP
rs1276971885 150 dbSNP
rs1491046994 150 dbSNP
rs200972192 150 dbSNP
rs201239844 150 dbSNP
rs869297586 150 dbSNP
rs1165039633 151 dbSNP
rs537739017 152 dbSNP
rs1193093843 154 dbSNP
rs568858311 157 dbSNP
rs1468556100 160 dbSNP
rs781137182 163 dbSNP
rs1379553992 173 dbSNP
rs1179032291 175 dbSNP
rs189424888 176 dbSNP
rs1475528330 177 dbSNP
rs1411456363 183 dbSNP
rs1250897719 184 dbSNP
rs535137302 189 dbSNP
rs1159506703 195 dbSNP
rs1362096831 196 dbSNP
rs1220421610 200 dbSNP
rs1297092046 205 dbSNP
rs1355522136 206 dbSNP
rs1450902249 207 dbSNP
rs1282947159 208 dbSNP
rs1379006615 212 dbSNP
rs1224708083 215 dbSNP
rs1311879180 217 dbSNP
rs1000216168 221 dbSNP
rs1216148157 239 dbSNP
rs1281212884 241 dbSNP
rs1291427595 242 dbSNP
rs566524843 253 dbSNP
rs768617789 254 dbSNP
rs1202791052 256 dbSNP
rs1177607713 261 dbSNP
rs370905204 266 dbSNP
rs1381908522 268 dbSNP
rs1437494869 272 dbSNP
rs749738220 274 dbSNP
rs967428162 276 dbSNP
rs1020411196 281 dbSNP
rs556959467 282 dbSNP
rs1415693289 284 dbSNP
rs1009798637 290 dbSNP
rs184545170 297 dbSNP
rs1309262376 301 dbSNP
rs1443536290 309 dbSNP
rs1311994745 312 dbSNP
rs28399545 315 dbSNP
rs141961372 318 dbSNP
rs1304464933 327 dbSNP
rs1347338578 338 dbSNP
rs1217579221 340 dbSNP
rs551238635 345 dbSNP
rs1277960135 351 dbSNP
rs996739323 354 dbSNP
rs899761071 357 dbSNP
rs78412933 359 dbSNP
rs1456281014 366 dbSNP
rs1417096781 371 dbSNP
rs1436067170 383 dbSNP
rs941043084 386 dbSNP
rs886844627 387 dbSNP
rs1170349749 390 dbSNP
rs28399546 390 dbSNP
rs1411082714 392 dbSNP
rs950261621 396 dbSNP
rs138366534 397 dbSNP
rs562397622 401 dbSNP
rs1326952225 405 dbSNP
rs542192832 408 dbSNP
rs917458000 414 dbSNP
rs1434550157 416 dbSNP
rs528492186 421 dbSNP
rs1274395233 424 dbSNP
rs149961969 443 dbSNP
rs937586127 444 dbSNP
rs545990584 448 dbSNP
rs751169743 449 dbSNP
rs1159245146 450 dbSNP
rs1421421075 457 dbSNP
rs758145825 465 dbSNP
rs1190360247 469 dbSNP
rs753040503 473 dbSNP
rs1267762377 474 dbSNP
rs1453032225 475 dbSNP
rs13599 479 dbSNP
rs967397055 480 dbSNP
rs576964112 484 dbSNP
rs1190571275 488 dbSNP
rs1465538218 490 dbSNP
rs1166160962 493 dbSNP
rs374145763 496 dbSNP
rs750057482 497 dbSNP
rs1487708855 501 dbSNP
rs987609551 510 dbSNP
rs1286081464 512 dbSNP
rs1327185427 516 dbSNP
rs1218040290 519 dbSNP
rs1401944529 524 dbSNP
rs557525075 528 dbSNP
rs954970276 531 dbSNP
rs767770478 534 dbSNP
rs1338388906 544 dbSNP
rs1029455673 562 dbSNP
rs1194020267 574 dbSNP
rs1358209330 575 dbSNP
rs1218947880 580 dbSNP
rs1288733994 589 dbSNP
rs997100356 599 dbSNP
rs899729976 607 dbSNP
rs544029087 608 dbSNP
rs575176493 609 dbSNP
rs1368584247 616 dbSNP
rs1276901842 619 dbSNP
rs1016834091 621 dbSNP
rs1456725593 628 dbSNP
rs1005155773 630 dbSNP
rs1361446259 637 dbSNP
rs370082754 642 dbSNP
rs555388473 643 dbSNP
rs1359975559 646 dbSNP
rs1469565636 650 dbSNP
rs1047244120 651 dbSNP
rs1313363273 653 dbSNP
rs949791946 658 dbSNP
rs1242384851 661 dbSNP
rs3825178 664 dbSNP
rs1354037975 669 dbSNP
rs1218320978 670 dbSNP
rs778583928 672 dbSNP
rs1487677141 683 dbSNP
rs1200469616 691 dbSNP
rs1401788615 692 dbSNP
rs1422537535 694 dbSNP
rs937523547 700 dbSNP
rs926175710 707 dbSNP
rs139186460 708 dbSNP
rs946024866 711 dbSNP
rs1360072554 712 dbSNP
rs1466638257 722 dbSNP
rs753442741 728 dbSNP
rs913204596 729 dbSNP
rs1426992294 737 dbSNP
rs1394198756 741 dbSNP
rs1335912005 744 dbSNP
rs14992 745 dbSNP
rs757146409 752 dbSNP
rs1241960495 753 dbSNP
rs547771001 755 dbSNP
rs1306643210 757 dbSNP
rs1352462091 764 dbSNP
rs987877661 769 dbSNP
rs1257211616 770 dbSNP
rs1482590389 772 dbSNP
rs1200382945 786 dbSNP
rs954791056 787 dbSNP
rs1459382248 794 dbSNP
rs1177109671 799 dbSNP
rs1029503269 803 dbSNP
rs975259572 805 dbSNP
rs1178391469 810 dbSNP
rs1375989403 811 dbSNP
rs1464537565 816 dbSNP
rs963868526 831 dbSNP
rs539153082 839 dbSNP
rs1400866175 840 dbSNP
rs1489565318 842 dbSNP
rs1448744398 850 dbSNP
rs1328994668 851 dbSNP
rs1236162876 852 dbSNP
rs1372204856 856 dbSNP
rs570609656 868 dbSNP
rs1302846046 872 dbSNP
rs551177114 875 dbSNP
rs1210028929 884 dbSNP
rs1309939427 887 dbSNP
rs1016803102 890 dbSNP
rs1005458383 891 dbSNP
rs763677370 893 dbSNP
rs1237934519 905 dbSNP
rs761319643 909 dbSNP
rs1313217022 918 dbSNP
rs28399547 918 dbSNP
rs1025285379 920 dbSNP
rs1193137290 920 dbSNP
rs1432681906 921 dbSNP
rs1014351365 922 dbSNP
rs1424282256 924 dbSNP
rs529355526 924 dbSNP
rs753249100 924 dbSNP
rs1353693471 926 dbSNP
rs1458163111 926 dbSNP
rs1294939233 927 dbSNP
rs1364993306 932 dbSNP
rs1001702436 933 dbSNP
rs1278246095 933 dbSNP
rs1342992455 934 dbSNP
rs904729118 945 dbSNP
rs1043257264 946 dbSNP
rs867735009 954 dbSNP
rs531165339 955 dbSNP
rs767773887 956 dbSNP
rs759887561 959 dbSNP
rs1194524916 961 dbSNP
rs779449155 962 dbSNP
rs1478794868 969 dbSNP
rs1360721658 975 dbSNP
rs946244057 989 dbSNP
rs568738226 990 dbSNP
rs1424202721 994 dbSNP
rs1166600843 1003 dbSNP
rs151203728 1010 dbSNP
rs897887586 1011 dbSNP
rs28399548 1017 dbSNP
rs561800502 1019 dbSNP
rs887937383 1023 dbSNP
rs1056078168 1028 dbSNP
rs1380461669 1029 dbSNP
rs922023050 1029 dbSNP
rs709222 1030 dbSNP
rs1181842231 1032 dbSNP
rs963839460 1033 dbSNP
rs909684930 1041 dbSNP
rs983938149 1047 dbSNP
rs1241479413 1055 dbSNP
rs1239599738 1066 dbSNP
rs1183432800 1073 dbSNP
rs1483520007 1073 dbSNP
rs771143486 1074 dbSNP
rs928336863 1076 dbSNP
rs1197075177 1081 dbSNP
rs1411346641 1088 dbSNP
rs981485389 1090 dbSNP
rs951271162 1092 dbSNP
rs1158883477 1093 dbSNP
rs1381711671 1094 dbSNP
rs77126965 1097 dbSNP
rs1259017358 1103 dbSNP
rs532447480 1111 dbSNP
rs1450786600 1113 dbSNP
rs1301516235 1114 dbSNP
rs1382490910 1115 dbSNP
rs1241244147 1117 dbSNP
rs1320048143 1118 dbSNP
rs1311768774 1134 dbSNP
rs912945981 1141 dbSNP
rs989895372 1142 dbSNP
rs1279399088 1144 dbSNP
rs1442995978 1154 dbSNP
rs1228848280 1155 dbSNP
rs1212149633 1158 dbSNP
rs1381194617 1168 dbSNP
rs763052876 1169 dbSNP
rs1239650137 1172 dbSNP
rs1437399681 1179 dbSNP
rs750930530 1180 dbSNP
rs1218494272 1183 dbSNP
rs748548933 1184 dbSNP
rs1034093841 1193 dbSNP
rs563474957 1194 dbSNP
rs1405930339 1195 dbSNP
rs1333025048 1197 dbSNP
rs1459532642 1198 dbSNP
rs1333752929 1199 dbSNP
rs904273700 1200 dbSNP
rs1348837308 1202 dbSNP
rs1043225853 1206 dbSNP
rs1010424960 1213 dbSNP
rs1217493797 1217 dbSNP
rs1261196576 1225 dbSNP
rs1424915199 1226 dbSNP
rs1199078398 1227 dbSNP
rs1018108436 1228 dbSNP
rs1259724728 1228 dbSNP
rs985418433 1232 dbSNP
rs1435775896 1233 dbSNP
rs1180639128 1237 dbSNP
rs892037071 1242 dbSNP
rs1439527990 1249 dbSNP
rs955446693 1252 dbSNP
rs1239147226 1255 dbSNP
rs1200802212 1256 dbSNP
rs1052471826 1259 dbSNP
rs1173350822 1263 dbSNP
rs1398556017 1266 dbSNP
rs1030346880 1271 dbSNP
rs1324476406 1276 dbSNP
rs997894270 1280 dbSNP
rs921961403 1281 dbSNP
rs543966662 1283 dbSNP
rs769861060 1288 dbSNP
rs1006246939 1290 dbSNP
rs1344855777 1292 dbSNP
rs1323437297 1296 dbSNP
rs575116654 1308 dbSNP
rs555587169 1309 dbSNP
rs1056341890 1318 dbSNP
rs1290175773 1320 dbSNP
rs541764824 1326 dbSNP
rs573134218 1327 dbSNP
rs1267538835 1331 dbSNP
rs1384751614 1338 dbSNP
rs1435617 1342 dbSNP
rs746953832 1345 dbSNP
rs1366392348 1347 dbSNP
rs909313497 1372 dbSNP
rs1371784497 1381 dbSNP
rs983905629 1381 dbSNP
rs1164163287 1388 dbSNP
rs1393201205 1391 dbSNP
rs552692517 1394 dbSNP
rs531756260 1396 dbSNP
rs989928297 1397 dbSNP
rs1361244314 1398 dbSNP
rs1401851894 1399 dbSNP
rs935718687 1407 dbSNP
rs143359363 1409 dbSNP
rs1034389255 1411 dbSNP
rs979781046 1413 dbSNP
rs1358097530 1427 dbSNP
rs1243310990 1429 dbSNP
rs1290494453 1431 dbSNP
rs985670892 1433 dbSNP
rs955328035 1435 dbSNP
rs1260295864 1436 dbSNP
rs922473545 1447 dbSNP
rs570546936 1449 dbSNP
rs1446902904 1454 dbSNP
rs1180846321 1462 dbSNP
rs1188746116 1464 dbSNP
rs549648366 1469 dbSNP
rs139646823 1470 dbSNP
rs1163183138 1477 dbSNP
rs80271339 1482 dbSNP
rs1266861936 1488 dbSNP
rs1010392559 1490 dbSNP
rs745639535 1491 dbSNP
rs76835213 1495 dbSNP
rs1287150568 1496 dbSNP
rs1382760683 1497 dbSNP
rs1381567010 1498 dbSNP
rs1014858597 1499 dbSNP
rs182299506 1516 dbSNP
rs1342043932 1517 dbSNP
rs1030575777 1519 dbSNP
rs190527754 1521 dbSNP
rs952099348 1522 dbSNP
rs1215862623 1527 dbSNP
rs900756670 1540 dbSNP
rs1258413309 1544 dbSNP
rs1038982368 1555 dbSNP
rs756985808 1556 dbSNP
rs1201527501 1557 dbSNP
rs1034531295 1558 dbSNP
rs564690024 1564 dbSNP
rs1460272704 1565 dbSNP
rs1183319869 1566 dbSNP
rs907364271 1572 dbSNP
rs942065120 1573 dbSNP
rs1046437113 1582 dbSNP
rs753524918 1585 dbSNP
rs1363296243 1587 dbSNP
rs184762175 1591 dbSNP
rs1054100048 1592 dbSNP
rs1301608827 1595 dbSNP
rs1408141873 1597 dbSNP
rs535003294 1598 dbSNP
rs929817644 1601 dbSNP
rs1377249828 1602 dbSNP
rs534167675 1609 dbSNP
rs1296996564 1610 dbSNP
rs1334668688 1611 dbSNP
rs992676791 1613 dbSNP
rs1258312277 1614 dbSNP
rs910930362 1615 dbSNP
rs1203477752 1618 dbSNP
rs938572643 1626 dbSNP
rs566389765 1630 dbSNP
rs1175702827 1631 dbSNP
rs1361667484 1637 dbSNP
rs1049587224 1641 dbSNP
rs1464917704 1653 dbSNP
rs979753575 1655 dbSNP
rs933859414 1656 dbSNP
rs1377412460 1668 dbSNP
rs1177125120 1672 dbSNP
rs922455590 1674 dbSNP
rs972645975 1677 dbSNP
rs961253367 1678 dbSNP
rs907892097 1679 dbSNP
rs1309076000 1686 dbSNP
rs1296109047 1687 dbSNP
rs989002456 1691 dbSNP
rs1284610750 1695 dbSNP
rs552271569 1703 dbSNP
rs1488577326 1705 dbSNP
rs1223434446 1710 dbSNP
rs1279315389 1712 dbSNP
rs1320457812 1714 dbSNP
rs1202803642 1719 dbSNP
rs952166166 1720 dbSNP
rs997713016 1728 dbSNP
rs1266854296 1730 dbSNP
rs900737649 1732 dbSNP
rs1198612365 1734 dbSNP
rs532384660 1735 dbSNP
rs1430109823 1736 dbSNP
rs1006174783 1741 dbSNP
rs1353601835 1743 dbSNP
rs546210127 1744 dbSNP
rs1304498904 1746 dbSNP
rs1458076540 1746 dbSNP
rs567007332 1747 dbSNP
rs781639865 1756 dbSNP
rs887811625 1757 dbSNP
rs1034887638 1761 dbSNP
rs572696774 1762 dbSNP
rs549862250 1763 dbSNP
rs1322618126 1765 dbSNP
rs559935771 1773 dbSNP
rs896585361 1778 dbSNP
rs1289781429 1780 dbSNP
rs1490211959 1783 dbSNP
rs1217371963 1785 dbSNP
rs1263857193 1802 dbSNP
rs1315628855 1804 dbSNP
rs1277032983 1806 dbSNP
rs1184612947 1813 dbSNP
rs1024461342 1817 dbSNP
rs1418522936 1822 dbSNP
rs191972874 1827 dbSNP
rs1057336755 1830 dbSNP
rs1341832485 1843 dbSNP
rs561726012 1850 dbSNP
rs753265664 1853 dbSNP
rs1347510747 1854 dbSNP
rs1429218286 1881 dbSNP
rs892023513 1883 dbSNP
rs1288725528 1884 dbSNP
rs1380361944 1888 dbSNP
rs1454865044 1895 dbSNP
rs1054132582 1905 dbSNP
rs1313221358 1917 dbSNP
rs1358950065 1919 dbSNP
rs1241017662 1922 dbSNP
rs542057890 1926 dbSNP
rs541796990 1941 dbSNP
rs1303755640 1945 dbSNP
rs1471092910 1948 dbSNP
rs980056908 1949 dbSNP
rs999826140 1955 dbSNP
rs889458322 1957 dbSNP
rs1170229016 1963 dbSNP
rs1049978062 1964 dbSNP
rs1240929044 1965 dbSNP
rs914208007 1969 dbSNP
rs1158782074 1970 dbSNP
rs1478221351 1971 dbSNP
rs1374838982 1975 dbSNP
rs988499313 1988 dbSNP
rs1398388911 1989 dbSNP
rs933734558 1995 dbSNP
rs768019194 2011 dbSNP
rs1360204356 2013 dbSNP
rs751975020 2023 dbSNP
rs1335106790 2024 dbSNP
rs923058378 2032 dbSNP
rs976637387 2033 dbSNP
rs964886692 2034 dbSNP
rs1373532043 2046 dbSNP
rs1371291551 2048 dbSNP
rs146332177 2049 dbSNP
rs1324142481 2058 dbSNP
rs1205380316 2066 dbSNP
rs1261004483 2067 dbSNP
rs1460645591 2068 dbSNP
rs1201905508 2085 dbSNP
rs1456173197 2093 dbSNP
rs1234202637 2094 dbSNP
rs1006393849 2102 dbSNP
rs1176087549 2107 dbSNP
rs530933846 2109 dbSNP
rs187402457 2115 dbSNP
rs1405804243 2118 dbSNP
rs1466413690 2119 dbSNP
rs1198870023 2120 dbSNP
rs766628353 2123 dbSNP
rs1441617650 2125 dbSNP
rs1281897708 2133 dbSNP
rs909763334 2134 dbSNP
rs1275487545 2137 dbSNP
rs993523560 2144 dbSNP
rs1243298083 2147 dbSNP
rs983998964 2148 dbSNP
rs1281231814 2155 dbSNP
rs1322578118 2155 dbSNP
rs1056577970 2157 dbSNP
rs1274720183 2158 dbSNP
rs751865743 2160 dbSNP
rs763230441 2161 dbSNP
rs930672881 2162 dbSNP
rs545783079 2165 dbSNP
rs773356842 2167 dbSNP
rs905730482 2168 dbSNP
rs76386052 2169 dbSNP
rs1429140957 2180 dbSNP
rs1417694098 2181 dbSNP
rs1475962612 2181 dbSNP
rs576936964 2181 dbSNP
rs79497339 2181 dbSNP
rs879910506 2181 dbSNP
rs1367531991 2182 dbSNP
rs1398537269 2183 dbSNP
rs1330984435 2184 dbSNP
rs927302212 2189 dbSNP
rs1301243762 2192 dbSNP
rs1466307202 2197 dbSNP
rs1398767173 2202 dbSNP
rs1344759571 2206 dbSNP
rs1227939521 2219 dbSNP
rs557048819 2223 dbSNP
rs914511435 2225 dbSNP
rs1368913632 2226 dbSNP
rs765315433 2227 dbSNP
rs971482306 2228 dbSNP
rs1219569153 2229 dbSNP
rs551483790 2232 dbSNP
rs1448059014 2249 dbSNP
rs1195848633 2251 dbSNP
rs1185343473 2254 dbSNP
rs1475251094 2255 dbSNP
rs1164471395 2256 dbSNP
rs1437657701 2262 dbSNP
rs1237318428 2273 dbSNP
rs934367105 2282 dbSNP
rs1178909972 2294 dbSNP
rs1364939949 2297 dbSNP
rs1382698749 2300 dbSNP
rs988945509 2319 dbSNP
rs975890051 2323 dbSNP
rs956280136 2324 dbSNP
rs1315346686 2329 dbSNP
rs1208670371 2330 dbSNP
rs56731013 2343 dbSNP
rs761832911 2344 dbSNP
rs1352114193 2352 dbSNP
rs1207410850 2354 dbSNP
rs1260181820 2360 dbSNP
rs1446811328 2362 dbSNP
rs1033302614 2364 dbSNP
rs1245248288 2367 dbSNP
rs984940136 2370 dbSNP
rs1183129408 2375 dbSNP
rs1364453026 2386 dbSNP
rs537153093 2394 dbSNP
rs952266747 2403 dbSNP
rs1356270734 2406 dbSNP
rs772090036 2408 dbSNP
rs574522234 2411 dbSNP
rs1384616323 2415 dbSNP
rs183951557 2417 dbSNP
rs556257135 2419 dbSNP
rs1375193191 2429 dbSNP
rs993890328 2430 dbSNP
rs889480591 2436 dbSNP
rs960781074 2438 dbSNP
rs1240507493 2441 dbSNP
rs1259519164 2444 dbSNP
rs1308931911 2447 dbSNP
rs1035508730 2449 dbSNP
rs1204770651 2453 dbSNP
rs1447822751 2469 dbSNP
rs1337697723 2475 dbSNP
rs1002256953 2482 dbSNP
rs774262313 2494 dbSNP
rs1251443599 2495 dbSNP
rs1420987419 2496 dbSNP
rs780397640 2497 dbSNP
rs1404906970 2498 dbSNP
rs535254985 2502 dbSNP
rs1044228689 2507 dbSNP
rs1176971323 2508 dbSNP
rs1408028794 2512 dbSNP
rs1011428394 2513 dbSNP
rs893045909 2517 dbSNP
rs1396725255 2521 dbSNP
rs1392669197 2523 dbSNP
rs28399549 2523 dbSNP
rs28399550 2528 dbSNP
rs1285669351 2535 dbSNP
rs538599528 2537 dbSNP
rs748950214 2538 dbSNP
rs1244557572 2542 dbSNP
rs939896243 2548 dbSNP
rs1252147151 2553 dbSNP
rs888271443 2560 dbSNP
rs777506429 2571 dbSNP
rs1249904318 2577 dbSNP
rs1048327882 2579 dbSNP
rs943097582 2601 dbSNP
rs755707334 2604 dbSNP
rs747619859 2610 dbSNP
rs1431283706 2611 dbSNP
rs1479349976 2612 dbSNP
rs1175056770 2625 dbSNP
rs1373346240 2629 dbSNP
rs980098983 2631 dbSNP
rs984908959 2633 dbSNP
rs1369407202 2634 dbSNP
rs1241244229 2638 dbSNP
rs1404970444 2645 dbSNP
rs1353282334 2659 dbSNP
rs1273355611 2660 dbSNP
rs1435999308 2663 dbSNP
rs1331795251 2664 dbSNP
rs1344136296 2665 dbSNP
rs1304992495 2667 dbSNP
rs780535263 2668 dbSNP
rs950187233 2680 dbSNP
rs1225517444 2681 dbSNP
rs1398098828 2687 dbSNP
rs1360282342 2690 dbSNP
rs755555573 2694 dbSNP
rs577138031 2698 dbSNP
rs930839394 2700 dbSNP
rs141996513 2701 dbSNP
rs1489833793 2703 dbSNP
rs752007180 2704 dbSNP
rs1359759963 2706 dbSNP
rs1262167327 2712 dbSNP
rs1159033884 2718 dbSNP
rs1167895785 2724 dbSNP
rs1359785541 2728 dbSNP
rs919502181 2729 dbSNP
rs1422769140 2730 dbSNP
rs527643820 2732 dbSNP
rs961257801 2733 dbSNP
rs1289894768 2734 dbSNP
rs149250109 2738 dbSNP
rs988893286 2740 dbSNP
rs1364535144 2741 dbSNP
rs1380834278 2746 dbSNP
rs28399551 2747 dbSNP
rs1033167312 2751 dbSNP
rs969432680 2764 dbSNP
rs1289672759 2774 dbSNP
rs530136086 2782 dbSNP
rs979440053 2785 dbSNP
rs561860844 2796 dbSNP
rs1261180761 2799 dbSNP
rs1430814002 2813 dbSNP
rs1486738974 2816 dbSNP
rs758705621 2826 dbSNP
rs750665843 2835 dbSNP
rs954289245 2847 dbSNP
rs1028414007 2856 dbSNP
rs997821327 2862 dbSNP
rs1487595706 2864 dbSNP
rs1444850534 2865 dbSNP
rs1263182936 2869 dbSNP
rs900844182 2873 dbSNP
rs1382858990 2875 dbSNP
rs1217114641 2881 dbSNP
rs529287845 2891 dbSNP
rs1347420204 2894 dbSNP
rs1011412064 2895 dbSNP
rs1015329956 2904 dbSNP
rs1003904651 2906 dbSNP
rs1449146764 2917 dbSNP
rs1454781632 2927 dbSNP
rs2384848 2932 dbSNP
rs893003767 2933 dbSNP
rs765407584 2938 dbSNP
rs1031929354 2946 dbSNP
rs1224361883 2947 dbSNP
rs1276908307 2952 dbSNP
rs1307656919 2954 dbSNP
rs1318623982 2955 dbSNP
rs868463290 2956 dbSNP
rs1048202930 2957 dbSNP
rs1285292027 2959 dbSNP
rs1461550478 2960 dbSNP
rs561462815 2962 dbSNP
rs1205189486 2963 dbSNP
rs937938653 2964 dbSNP
rs548067987 2965 dbSNP
rs1044793969 2967 dbSNP
rs1177239886 2973 dbSNP
rs1158982137 2986 dbSNP
rs1410862083 2986 dbSNP
rs78917531 2996 dbSNP
rs888844885 3001 dbSNP
rs917248261 3003 dbSNP
rs77462034 3010 dbSNP
rs1053225290 3014 dbSNP
rs559358462 3017 dbSNP
rs533881128 3020 dbSNP
rs978916578 3024 dbSNP
rs1375526299 3029 dbSNP
rs1226501597 3030 dbSNP
rs972646556 3032 dbSNP
rs1324022078 3033 dbSNP
rs1414694149 3048 dbSNP
rs939596230 3049 dbSNP
rs1441458331 3050 dbSNP
rs1204677625 3052 dbSNP
rs79619065 3061 dbSNP
rs1481750205 3067 dbSNP
rs1168088242 3070 dbSNP
rs921568938 3073 dbSNP
rs1430550729 3075 dbSNP
rs1477242268 3077 dbSNP
rs1423695518 3083 dbSNP
rs977400267 3084 dbSNP
rs750509373 3090 dbSNP
rs1331058953 3091 dbSNP
rs1352850225 3099 dbSNP
rs1476653099 3100 dbSNP
rs965042451 3103 dbSNP
rs1346031223 3106 dbSNP
rs1406594211 3110 dbSNP
rs1015195617 3114 dbSNP
rs1003937003 3116 dbSNP
rs952437035 3118 dbSNP
rs1214804076 3119 dbSNP
rs1265309559 3124 dbSNP
rs1027241305 3127 dbSNP
rs547478288 3147 dbSNP
rs1339479037 3150 dbSNP
rs1196973341 3151 dbSNP
rs1002005358 3155 dbSNP
rs905023931 3157 dbSNP
rs563268798 3165 dbSNP
rs1046344940 3167 dbSNP
rs1013498423 3179 dbSNP
rs895846158 3180 dbSNP
rs112771058 3185 dbSNP
rs1197278141 3197 dbSNP
rs1246492240 3199 dbSNP
rs1317412895 3205 dbSNP
rs543469348 3215 dbSNP
rs535431664 3218 dbSNP
rs187775977 3224 dbSNP
rs1429230042 3225 dbSNP
rs1164266493 3230 dbSNP
rs568231363 3232 dbSNP
rs759581807 3233 dbSNP
rs1018839357 3241 dbSNP
rs1043530161 3252 dbSNP
rs932868877 3254 dbSNP
rs868597146 3256 dbSNP
rs1007180409 3257 dbSNP
rs1448566233 3259 dbSNP
rs888818653 3260 dbSNP
rs1408012241 3263 dbSNP
rs977055499 3264 dbSNP
rs965575925 3267 dbSNP
rs1227099619 3270 dbSNP
rs1328931659 3274 dbSNP
rs1048724601 3279 dbSNP
rs908231411 3289 dbSNP
rs182699138 3295 dbSNP
rs796133706 3300 dbSNP
rs2118528 3305 dbSNP
rs201597308 3307 dbSNP
rs994559448 3308 dbSNP
rs952467549 3311 dbSNP
rs897588325 3312 dbSNP
rs1400595498 3313 dbSNP
rs1036504879 3321 dbSNP
rs1387170390 3325 dbSNP
rs1456408270 3334 dbSNP
rs1161415976 3335 dbSNP
rs572600578 3336 dbSNP
rs1389876528 3338 dbSNP
rs939544436 3341 dbSNP
rs928219199 3345 dbSNP
rs1045374686 3346 dbSNP
rs1026775786 3347 dbSNP
rs948292102 3348 dbSNP
rs1245317329 3353 dbSNP
rs1384387316 3363 dbSNP
rs1177032481 3366 dbSNP
rs1457442872 3369 dbSNP
rs1002356198 3373 dbSNP
rs1251976547 3383 dbSNP
rs1206628598 3387 dbSNP
rs1319993819 3388 dbSNP
rs1207320555 3389 dbSNP
rs75958574 3390 dbSNP
rs79558218 3391 dbSNP
rs989498846 3400 dbSNP
rs1245145979 3402 dbSNP
rs1186897957 3410 dbSNP
rs956783528 3411 dbSNP
rs1384776801 3414 dbSNP
rs1470465787 3417 dbSNP
rs1161190926 3419 dbSNP
rs116667400 3424 dbSNP
rs374397065 3426 dbSNP
rs977261709 3437 dbSNP
rs1337013265 3441 dbSNP
rs892352442 3441 dbSNP
rs1393841772 3445 dbSNP
rs966309854 3445 dbSNP
rs770859805 3446 dbSNP
rs1336939334 3451 dbSNP
rs998893568 3453 dbSNP
rs1286939750 3454 dbSNP
rs1433763008 3457 dbSNP
rs1224464038 3459 dbSNP
rs1348784435 3464 dbSNP
rs1007399809 3466 dbSNP
rs1200004971 3467 dbSNP
rs904513010 3469 dbSNP
rs1439575153 3476 dbSNP
rs148721099 3481 dbSNP
rs35666 3486 dbSNP
rs900017049 3508 dbSNP
rs1472163076 3517 dbSNP
rs994925535 3522 dbSNP
rs1379066464 3537 dbSNP
rs1487617902 3549 dbSNP
rs897561578 3556 dbSNP
rs191084881 3561 dbSNP
rs1036545137 3562 dbSNP
rs1306753932 3564 dbSNP
rs1350376386 3565 dbSNP
rs1405991540 3566 dbSNP
rs1003712678 3580 dbSNP
rs1310736035 3582 dbSNP
rs944301776 3587 dbSNP
rs908759954 3590 dbSNP
rs1341595216 3591 dbSNP
rs982994333 3601 dbSNP
rs765160950 3603 dbSNP
rs1249584865 3606 dbSNP
rs1179153959 3611 dbSNP
rs1482680052 3611 dbSNP
rs1487574031 3612 dbSNP
rs1045260574 3616 dbSNP
rs931015509 3617 dbSNP
rs1269206888 3619 dbSNP
rs919573705 3621 dbSNP
rs1373250394 3629 dbSNP
rs552730259 3630 dbSNP
rs1166148652 3642 dbSNP
rs1283641112 3646 dbSNP
rs527988953 3652 dbSNP
rs1370549722 3653 dbSNP
rs547892572 3657 dbSNP
rs969521658 3663 dbSNP
rs1308776405 3664 dbSNP
rs1053778169 3670 dbSNP
rs773739751 3673 dbSNP
rs1024814552 3676 dbSNP
rs1296607580 3677 dbSNP
rs1367586765 3678 dbSNP
rs991950290 3679 dbSNP
rs956521885 3687 dbSNP
rs1226351072 3694 dbSNP
rs1274006283 3698 dbSNP
rs188653571 3709 dbSNP
rs1360168786 3710 dbSNP
rs1223147812 3717 dbSNP
rs1267093477 3719 dbSNP
rs1030955742 3724 dbSNP
rs199977695 3725 dbSNP
rs879866347 3733 dbSNP
rs747778726 3748 dbSNP
rs58636999 3756 dbSNP
rs144218131 3757 dbSNP
rs1022020667 3764 dbSNP
rs1296880881 3769 dbSNP
rs1167562564 3771 dbSNP
rs996954296 3775 dbSNP
rs1457758860 3781 dbSNP
rs754381217 3786 dbSNP
rs1027558197 3793 dbSNP
rs1297064637 3793 dbSNP
rs1161606873 3795 dbSNP
rs1431615555 3800 dbSNP
rs1383646156 3803 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucagaggaccuccACCAUUUUg 5'
                       |||||||| 
Target 5' -------------UGGUAAAAa 3'
 		1 - 9
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000256015.3 | 3UTR | UGGUAAAAAAAAAAAAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000256015.3 | 3UTR | AGAAUGGUAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000256015.3 | 3UTR | GAAUGGUAAAAAAAAAAAAAAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000256015.3 | 3UTR | ACAAGAUAGAAUGGUAAAAAAAAAAAAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
115 hsa-miR-2681-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT058831 NRAS NRAS proto-oncogene, GTPase 2 4
MIRT076301 ULK2 unc-51 like autophagy activating kinase 2 2 2
MIRT095503 PURA purine rich element binding protein A 2 12
MIRT097763 ARSK arylsulfatase family member K 2 2
MIRT170870 TAX1BP1 Tax1 binding protein 1 2 2
MIRT179045 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT189057 CLEC2D C-type lectin domain family 2 member D 2 8
MIRT241949 BTG1 BTG anti-proliferation factor 1 2 4
MIRT261860 ZRANB1 zinc finger RANBP2-type containing 1 2 2
MIRT309357 OTUD4 OTU deubiquitinase 4 2 2
MIRT340568 SMIM12 small integral membrane protein 12 2 4
MIRT351983 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT351986 MOB4 MOB family member 4, phocein 2 8
MIRT353140 RAB10 RAB10, member RAS oncogene family 2 2
MIRT387104 VEZF1 vascular endothelial zinc finger 1 2 2
MIRT441833 SLC30A7 solute carrier family 30 member 7 2 2
MIRT443778 MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 2 4
MIRT448135 CMTM6 CKLF like MARVEL transmembrane domain containing 6 2 2
MIRT450638 ZMYM2 zinc finger MYM-type containing 2 2 2
MIRT494763 AP1G1 adaptor related protein complex 1 gamma 1 subunit 2 2
MIRT498299 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT505104 YTHDC1 YTH domain containing 1 2 6
MIRT507179 G3BP2 G3BP stress granule assembly factor 2 2 6
MIRT516638 ZNF318 zinc finger protein 318 2 4
MIRT520011 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 4
MIRT526877 GJD3 gap junction protein delta 3 2 2
MIRT529374 SKP1 S-phase kinase associated protein 1 2 2
MIRT530090 SHISA2 shisa family member 2 2 2
MIRT536514 KCTD10 potassium channel tetramerization domain containing 10 2 2
MIRT536559 JMJD1C jumonji domain containing 1C 2 2
MIRT536624 IPO7 importin 7 2 2
MIRT544378 ZNF266 zinc finger protein 266 2 2
MIRT547590 LIN28B lin-28 homolog B 2 2
MIRT548736 CREBBP CREB binding protein 2 2
MIRT551485 TMEM192 transmembrane protein 192 2 4
MIRT552322 ZNF791 zinc finger protein 791 2 4
MIRT553193 UBE2A ubiquitin conjugating enzyme E2 A 2 2
MIRT553719 TBX18 T-box 18 2 2
MIRT554573 RRAS2 RAS related 2 2 2
MIRT557038 HOXB3 homeobox B3 2 2
MIRT559566 ARF1 ADP ribosylation factor 1 2 2
MIRT560134 INO80D INO80 complex subunit D 2 2
MIRT560406 JUN Jun proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT561712 PTMA prothymosin, alpha 2 2
MIRT562688 ABI2 abl interactor 2 2 2
MIRT563214 FXN frataxin 2 2
MIRT566288 PROX1 prospero homeobox 1 2 4
MIRT567369 GTPBP3 GTP binding protein 3, mitochondrial 2 2
MIRT571380 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT574743 GOLGA4 golgin A4 2 2
MIRT576816 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT609984 ZHX1 zinc fingers and homeoboxes 1 2 4
MIRT610518 HIAT1 major facilitator superfamily domain containing 14A 2 2
MIRT612203 NKTR natural killer cell triggering receptor 2 4
MIRT612224 DHX33 DEAH-box helicase 33 2 6
MIRT612889 HOOK3 hook microtubule tethering protein 3 2 2
MIRT613639 DUSP18 dual specificity phosphatase 18 2 4
MIRT614161 PHF8 PHD finger protein 8 2 2
MIRT614630 WDR13 WD repeat domain 13 2 4
MIRT615001 FXR1 FMR1 autosomal homolog 1 2 4
MIRT615665 TSC22D2 TSC22 domain family member 2 2 2
MIRT615976 KAT6A lysine acetyltransferase 6A 2 2
MIRT616328 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT616495 AIPL1 aryl hydrocarbon receptor interacting protein like 1 2 2
MIRT616585 ZNF460 zinc finger protein 460 2 2
MIRT616870 ARPC1B actin related protein 2/3 complex subunit 1B 2 4
MIRT617631 RXRA retinoid X receptor alpha 2 2
MIRT620339 TLN1 talin 1 2 2
MIRT621658 UBE4B ubiquitination factor E4B 2 2
MIRT621824 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT622134 SOX4 SRY-box 4 2 2
MIRT622154 SNTG1 syntrophin gamma 1 2 2
MIRT622298 SGK3 serum/glucocorticoid regulated kinase family member 3 2 2
MIRT622531 RAB9B RAB9B, member RAS oncogene family 2 2
MIRT622596 PRRC2B proline rich coiled-coil 2B 2 2
MIRT623328 MAK16 MAK16 homolog 2 2
MIRT624499 C8orf44-SGK3 C8orf44-SGK3 readthrough 2 2
MIRT624720 AP1S2 adaptor related protein complex 1 sigma 2 subunit 2 2
MIRT625990 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT626143 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT626499 ARHGAP9 Rho GTPase activating protein 9 2 2
MIRT627023 CREBL2 cAMP responsive element binding protein like 2 2 2
MIRT635710 HFM1 HFM1, ATP dependent DNA helicase homolog 2 2
MIRT635725 CCDC58 coiled-coil domain containing 58 2 2
MIRT637121 MKX mohawk homeobox 2 2
MIRT639969 POU5F1B POU class 5 homeobox 1B 2 2
MIRT640962 GPRASP1 G protein-coupled receptor associated sorting protein 1 2 4
MIRT641067 HHIPL1 HHIP like 1 2 2
MIRT644800 NKX3-2 NK3 homeobox 2 2 2
MIRT644958 STEAP4 STEAP4 metalloreductase 2 2
MIRT649152 LRTM1 leucine rich repeats and transmembrane domains 1 2 2
MIRT651887 UFD1L ubiquitin recognition factor in ER associated degradation 1 2 2
MIRT652165 TRIM66 tripartite motif containing 66 2 2
MIRT652565 TLR6 toll like receptor 6 2 2
MIRT653127 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT655622 ONECUT1 one cut homeobox 1 2 2
MIRT656245 MEX3A mex-3 RNA binding family member A 2 2
MIRT656837 KLF7 Kruppel like factor 7 2 2
MIRT656990 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT660337 BCL10 B-cell CLL/lymphoma 10 2 2
MIRT660393 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT660940 ACER3 alkaline ceramidase 3 2 2
MIRT661509 C8orf82 chromosome 8 open reading frame 82 2 2
MIRT665000 KLF2 Kruppel like factor 2 2 2
MIRT665106 TNFSF8 TNF superfamily member 8 2 2
MIRT665547 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT687376 NT5DC3 5'-nucleotidase domain containing 3 2 2
MIRT711828 SIGLEC9 sialic acid binding Ig like lectin 9 2 2
MIRT713313 VLDLR very low density lipoprotein receptor 2 2
MIRT715654 PPM1K protein phosphatase, Mg2+/Mn2+ dependent 1K 2 2
MIRT715735 CD226 CD226 molecule 2 2
MIRT717255 SLC44A1 solute carrier family 44 member 1 2 2
MIRT717950 MIA3 MIA family member 3, ER export factor 2 2
MIRT719709 CD101 CD101 molecule 2 2
MIRT723893 NUDT21 nudix hydrolase 21 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-2681-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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