miRTarBase - #MIRT243304


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pre-miRNA Information
pre-miRNA hsa-mir-4534   
Genomic Coordinates chr22: 37988794 - 37988853
Description Homo sapiens miR-4534 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4534
Sequence 36| GGAUGGAGGAGGGGUCU |52
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs890798116 2 dbSNP
rs1382774432 11 dbSNP
rs982883970 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SLC25A36   
Synonyms PNC2
Description solute carrier family 25 member 36
Transcript NM_001104647   
Other Transcripts NM_018155   
Expression
Putative miRNA Targets on SLC25A36
3'UTR of SLC25A36
(miRNA target sites are highlighted)		 
>SLC25A36|NM_001104647|3'UTR
   1 CAGCACGAGGACTGCTGTACTGCAAAAAAAGAAGACCAAAAGATTACAGTGGACCATGGGATACAGAAGCCAGCATGGCA
  81 GACAGAAGAAAAATAGTTTGGGAACATGTAACTATTCTAAGTGGAAGTTTTGTTGTAGGAATTATAGTAATCACACCACA
 161 TTACTTGGCCTTTCGGTAATGTGAAAAAAAAAAAAAACCTCAGAGCCTCCAAGGAAATGCCTTTAGAAGCACTCCTCTCT
 241 CAAAATTGCCATTTTCTCTACCATGTCCCCCAGACACAGTTGGGTTTTGTTGATTTATGGCAGTCTTCTAAACAAAGCCA
 321 TCCTTAATTTTACATACTGTATTGTAACTATCCAAAGATAGTATTGGCAGTCATAAATTTATAACTTCTGGCCTTTGTTT
 401 AATTCCAGTAAAATAACAGCAATGACAATGAGATCGTCAGTATTATTTTCACATTTCCCTGAGAGGACCTGGCACAATAT
 481 TTTAAATTTAATTATTTGGCAGTAGTCACTGTTTTTGACAACCAATGAAATAGCGTCTAAATATCTTGTATATTTTTTAG
 561 CATCAAAATGTTTTGGTTTCCACTGCTGACAGGTGCTTGTTGTTTAGCCTAATGTGGATATTTAAATTGTTAACATACCA
 641 AACACACATGGTAATAGTTTGGGACAAAATAACTAGTAAAATGTTGATTTCTCGGCTATTTCACTGACTGCGGCATGTCC
 721 TCGTGTCTTCTCTGATTTTGTGGTACATGAATGAATGCATTTATCTTTTTAGTGACTTACTAGTTACGAACTTGAATTAT
 801 CACCTCTTTGTCATACTTAAGTATCATTTACATAAAGTGTAAAAGATTTTTTCACTTTTGAATCTTTACCTACTTGCTTT
 881 CACATTAAGAATTTGAACTTTTGAGTTTTTTCCAGGTCTATATATAATAGATTACATTTATTTTGTAAAGAAAATAGTAA
 961 TTTAAAGTTTTGCCATTTTAAGGTGACAATATTTGGGACAGTATAAATATTATAGACAAGGGCCCCCTTGCTGTCTGCTT
1041 TAGCAGGTAGTGACATTAATTGACTTATAGTTTTGTGTAAATGAACAAACTGCTTTTGACAAGAAATTTATTCTGTCCTA
1121 GTTTCCTGCGTGGTAAATCATAGAAAGATTCAAGTTCATTTGGGTTAAATGTGCTAATAGGATGTAGCTTTTAAATTCTG
1201 CTATTGAGTCAGCTGTACCTTTTAATACTTTAAATGTGTTATTTGTATGGCCCTTATAAAGGTGTTTGCTGTAATTCTGT
1281 TAAAAGACTTCGCCTATGCCATACTGGTGTATAAAAACTGCCGCAATTGGACGCCGGTGTGGTACTCATTTCAGTATACC
1361 TGAACTGTACATTTTGTGCAATGGCTTTATCTAAAAGAATGACGCTTCGTGAAAGCACTTTGTGGCCTTTTTTGGGGGGG
1441 AGGGTGAGAGAGTAGGAGAGAATACCATGTTAAGATTAAAAAAAAAAACAAAAACATTGGTCATGTATTAGGCAGAAACA
1521 GTGTTCATAACATTTTTCTGGGTTTTAAATATGTTGTTTCGGATATCCTTAATATAAATGTTTTAGGTATTCTGTGTACC
1601 CTGTCGTACCCCCAACATTATAGAATATTGCAGCGTGTCATTGCAAGCTTTCTCTGCTGTCACCAGTGAAACATAGTGCC
1681 CTGTTAAATTCCCCCACTTTAACTTCCTTGTGATCAACAGTAACTGGATGTTTTTGAGGTGCTCAATTGGAATAAAAATA
1761 TTCCAATCTATTTGGAGACCAAAGGCAAAATCAGTTTTCTTACCTTTGGAATTATTCGTACCTTTTATGGTAAATTTCAG
1841 CTTTGACATGTATTATGAGGAACGTACCAAAAACCGGTTTGTAACAAATCTGTAGAGAAGGTCTGAATCTATCGTGTTTG
1921 CCTTTTCAGGTGCCATTTCTACTGCCTAATACAGTGCCATTTGCCTTGTGAAGACCCATAAACATTCATTGTGTTGAATG
2001 TAAGATAGAGACTCTCCCTAGTCTTACTGATCTCAGTACCCCACAAATGATTAAGAATGATATGAAAACCAGCAGCTAAG
2081 GAACATCTTATTATTTAGTTGTAGCATATTCATAACAAGTGTCCTTCAAGGATAAACATATATTCTCTATTTGTATTTAG
2161 CAAGTAAAACTTGTGTTGACCTTTAGTGCATTATATTCAGCTTTTAACAGTATTATGTATGTACTGGAAAGCAAAGAAAT
2241 CTTAGAGTCTTGGACATTGTTTATTTGTGCAACAACTAGAAAGGAGCAATGAAGTTTATTTCAGTTGTATTTTTCCCTAA
2321 GCACAATCTGCAATAGTTTATGTATGACAGAGATAATTCAAAAAGGAAAACTATATATAAAAGTTGTATATAAAGTTTGT
2401 CTCTGAAATATTTCTTTGAAGTTTTTAAAAAATCGACTCATGTTTAAAAACAAAAACACATATTCAGAGCATTGGACTTT
2481 TTTAACTTGTTTTCATCTGTTTATCATGACTTTTTTATTTCTGGTGTAGAGTCCACATTATTTAGTTTGTTGTACTTTTA
2561 AATTTCAAAGTTCAAATCTGAAGAATTAGCGTTTGTGATTTCGGGATACCATGCAGTGGTTTTAATCCCAGGAAAAAAAC
2641 TATCACCAAAAGTTCGTTTGATTCTCATTATGTAACTTTGTAGAACCATCCTTTCTAGATGGGTCCACCACAGTGAATTT
2721 GTAACTTTGAAGTCAGGATAGAATATCATTAGATTATCTGTGAGATAGCATTACTATGTTAGGACCAGCAGAGTTTGGGT
2801 TGGTAAAAATAATGTTTGCTCTATTACTGGGTTACAGACATTTCAGCATTTTTAGGTTGGTTTTAAATCACTAAAAATAT
2881 TTATTCGGATTTGAAGGATTTAAGTGCTAAAAATCAATCCATTTCTTGCCCTTCAATAATTGTCCATGCCTGCCTTTTGT
2961 TGTTTACATGCTCTTCTGCCCAGACTGTTAGTAATCTAGGGACCCCCTTTGGAGCTGATAAGTACAGTTCAGCCTTTTCT
3041 CCTCAAATATATAATGACTTTAACATTCCTAAGAATATAGGTATTTCTGAATGATTTAAATTTGAGGAATTTTAATACAT
3121 AAAATACAATGTACAAACTTTCTGCCCACTCAGATCTCTTCTCCATCATGTACTTAGTATTTCCCATTAACCTACACACT
3201 GATTTTTATGCTACTCCTTGTAGAAACAAAATTCTGGTTTGACTCAGTTTTTGTGTTTATAAACTTTTGGAATGTGTACC
3281 CCGTTTATGTGAAGAATTATGACCTATCAGTCATAGCTAAATAGTGAACCTCAAAAGTGTTAACTTTTGACTATTCATGT
3361 GAGGTTTGGTATCTTGCATTTATGTACATGGCTGTAAATTATGTGCATTTACTCTGTATTTATGTTATCTAGCTGACTTT
3441 TACTTGAATTGTTCAAATTTTAAAAATTAAAATACGCTCATGAAAATATGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucUGGGGAGGAGGUAGg 5'
            |:|:||:||||||| 
Target 5' agATCTCTTCTCCATCa 3'
 3152 - 3168 163.00 -25.20
2 
miRNA  3' ucUGGGGAGGAGGUAGg 5'
            |: : |:|||:||: 
Target 5' acATATATTCTCTATTt 3'
 2136 - 2152 115.00 -7.50
3 
miRNA  3' ucUGGGGAGGAGGUAGg 5'
            | |:: ::|:|||| 
Target 5' ttAACTTGTTTTCATCt 3'
 2482 - 2498 115.00 -8.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26995089 15 COSMIC
COSN26995090 16 COSMIC
COSN31563606 23 COSMIC
COSN30570196 31 COSMIC
COSN30150833 59 COSMIC
COSN6752792 86 COSMIC
COSN30528296 94 COSMIC
COSN31547004 94 COSMIC
COSN18717754 115 COSMIC
COSN6752793 116 COSMIC
COSN20099161 198 COSMIC
COSN32065713 925 COSMIC
COSN32064925 1082 COSMIC
COSN17408237 1388 COSMIC
COSN27285635 1489 COSMIC
COSN27408852 1489 COSMIC
COSN9131915 1490 COSMIC
COSN30028477 1634 COSMIC
COSN9131916 2738 COSMIC
COSN17123348 3284 COSMIC
COSN15880383 3303 COSMIC
COSN25888213 3392 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs892805656 1 dbSNP
rs767365478 4 dbSNP
rs752474203 7 dbSNP
rs549405801 8 dbSNP
rs777689063 9 dbSNP
rs753765285 11 dbSNP
rs16850948 13 dbSNP
rs891274453 15 dbSNP
rs367703117 18 dbSNP
rs746145912 19 dbSNP
rs1303135207 22 dbSNP
rs371005552 23 dbSNP
rs1235366473 24 dbSNP
rs200860868 25 dbSNP
rs747382736 26 dbSNP
rs777302017 28 dbSNP
rs777901972 29 dbSNP
rs1437581699 30 dbSNP
rs1488444032 30 dbSNP
rs1189836221 31 dbSNP
rs202056920 36 dbSNP
rs148717177 38 dbSNP
rs1008421585 41 dbSNP
rs962715467 52 dbSNP
rs548415519 83 dbSNP
rs918637610 92 dbSNP
rs1471266175 93 dbSNP
rs934061662 94 dbSNP
rs1193213845 96 dbSNP
rs773638819 100 dbSNP
rs964321361 103 dbSNP
rs911382056 106 dbSNP
rs565759396 108 dbSNP
rs1043954628 109 dbSNP
rs539674182 115 dbSNP
rs35338784 118 dbSNP
rs1414954099 120 dbSNP
rs925616326 124 dbSNP
rs1359889446 126 dbSNP
rs1339251832 133 dbSNP
rs1270880748 136 dbSNP
rs1230613886 140 dbSNP
rs935629542 142 dbSNP
rs1336386736 145 dbSNP
rs1052716169 146 dbSNP
rs891579550 154 dbSNP
rs918021276 155 dbSNP
rs34945410 156 dbSNP
rs1324150486 175 dbSNP
rs1205544424 176 dbSNP
rs1168008012 177 dbSNP
rs1261016600 180 dbSNP
rs971187314 180 dbSNP
rs867584930 181 dbSNP
rs1382852050 182 dbSNP
rs369242618 184 dbSNP
rs397742724 184 dbSNP
rs63101963 184 dbSNP
rs869172406 184 dbSNP
rs1274248331 186 dbSNP
rs1207900466 189 dbSNP
rs1441636022 190 dbSNP
rs1193380070 194 dbSNP
rs201888650 199 dbSNP
rs1013945231 206 dbSNP
rs1474119182 210 dbSNP
rs376987648 212 dbSNP
rs1045995615 217 dbSNP
rs1353694639 228 dbSNP
rs905670363 230 dbSNP
rs1431517515 231 dbSNP
rs1162326860 232 dbSNP
rs1424066942 234 dbSNP
rs1415431557 236 dbSNP
rs1175860102 238 dbSNP
rs927976473 241 dbSNP
rs1233810828 246 dbSNP
rs1185019964 251 dbSNP
rs1489995985 253 dbSNP
rs1001873782 261 dbSNP
rs1016820281 264 dbSNP
rs1192266687 266 dbSNP
rs1054386758 267 dbSNP
rs1291160930 267 dbSNP
rs770421918 277 dbSNP
rs1282491846 283 dbSNP
rs1223428200 291 dbSNP
rs1372402193 297 dbSNP
rs1288726930 301 dbSNP
rs568274148 306 dbSNP
rs963037693 309 dbSNP
rs994210453 310 dbSNP
rs549295611 317 dbSNP
rs955471379 323 dbSNP
rs376805711 334 dbSNP
rs1351098298 335 dbSNP
rs570204907 338 dbSNP
rs1156571449 339 dbSNP
rs1008390209 345 dbSNP
rs890906707 345 dbSNP
rs986865363 352 dbSNP
rs1268717049 354 dbSNP
rs911399151 356 dbSNP
rs1027252301 373 dbSNP
rs1240402084 377 dbSNP
rs537441752 380 dbSNP
rs1401668903 382 dbSNP
rs191856197 392 dbSNP
rs1320485759 399 dbSNP
rs964210330 408 dbSNP
rs1229935829 418 dbSNP
rs1321350601 423 dbSNP
rs1004242553 429 dbSNP
rs1387269482 435 dbSNP
rs1025002276 437 dbSNP
rs759199397 445 dbSNP
rs1429616372 455 dbSNP
rs11542224 458 dbSNP
rs1161830477 461 dbSNP
rs142246423 464 dbSNP
rs925596758 467 dbSNP
rs980823925 469 dbSNP
rs1435404644 481 dbSNP
rs1417490751 483 dbSNP
rs1034111662 495 dbSNP
rs1047306 496 dbSNP
rs1273020784 511 dbSNP
rs1201990250 512 dbSNP
rs1343967921 512 dbSNP
rs1459862302 523 dbSNP
rs1262242144 524 dbSNP
rs1233938873 526 dbSNP
rs1205535458 535 dbSNP
rs990448508 536 dbSNP
rs914517369 540 dbSNP
rs1213408424 553 dbSNP
rs1365488779 554 dbSNP
rs1322213081 563 dbSNP
rs1449975607 567 dbSNP
rs945689750 569 dbSNP
rs577790771 574 dbSNP
rs763052536 577 dbSNP
rs949819736 585 dbSNP
rs1353201875 591 dbSNP
rs764133514 596 dbSNP
rs1215519452 597 dbSNP
rs905702242 606 dbSNP
rs58945853 609 dbSNP
rs1038610135 612 dbSNP
rs1182017277 613 dbSNP
rs184035331 618 dbSNP
rs898450726 622 dbSNP
rs994072921 637 dbSNP
rs1200777351 640 dbSNP
rs943731940 641 dbSNP
rs531350725 652 dbSNP
rs1481135663 654 dbSNP
rs1204346085 660 dbSNP
rs1039483219 664 dbSNP
rs1197827484 672 dbSNP
rs1243349680 676 dbSNP
rs866282150 686 dbSNP
rs543357584 694 dbSNP
rs1470819448 695 dbSNP
rs2680674 699 dbSNP
rs529160198 703 dbSNP
rs1406310482 707 dbSNP
rs1202559686 712 dbSNP
rs1298169193 713 dbSNP
rs1008736669 723 dbSNP
rs139728036 724 dbSNP
rs1004613871 727 dbSNP
rs964472608 747 dbSNP
rs1369202763 760 dbSNP
rs1188014720 774 dbSNP
rs1303984842 775 dbSNP
rs1367463855 777 dbSNP
rs145255970 778 dbSNP
rs1403204705 787 dbSNP
rs925429417 788 dbSNP
rs533152499 789 dbSNP
rs1219538224 806 dbSNP
rs1355229372 812 dbSNP
rs780236694 818 dbSNP
rs1330418395 821 dbSNP
rs1246534398 824 dbSNP
rs906551342 842 dbSNP
rs149851739 865 dbSNP
rs1281061300 870 dbSNP
rs766451013 878 dbSNP
rs1351321680 899 dbSNP
rs551651045 902 dbSNP
rs570119900 903 dbSNP
rs1292075059 905 dbSNP
rs1490684424 906 dbSNP
rs988327182 915 dbSNP
rs1404347215 919 dbSNP
rs1391527875 921 dbSNP
rs147608820 923 dbSNP
rs1361874557 927 dbSNP
rs1451868343 927 dbSNP
rs140794747 929 dbSNP
rs567570453 939 dbSNP
rs958765275 946 dbSNP
rs1253816878 948 dbSNP
rs3755765 949 dbSNP
rs1021952265 956 dbSNP
rs927105291 959 dbSNP
rs967357949 960 dbSNP
rs189112342 964 dbSNP
rs937080750 970 dbSNP
rs1267925441 971 dbSNP
rs1229320871 973 dbSNP
rs1038236109 984 dbSNP
rs539480712 990 dbSNP
rs57139286 993 dbSNP
rs1164398592 994 dbSNP
rs1331803521 1002 dbSNP
rs912199881 1002 dbSNP
rs545193359 1004 dbSNP
rs201263436 1007 dbSNP
rs3834196 1008 dbSNP
rs929896639 1014 dbSNP
rs1319662891 1023 dbSNP
rs1046986552 1026 dbSNP
rs1413903948 1032 dbSNP
rs1397377879 1046 dbSNP
rs1391893731 1048 dbSNP
rs72991059 1053 dbSNP
rs1008267906 1057 dbSNP
rs1330821685 1061 dbSNP
rs887355141 1063 dbSNP
rs1018682566 1065 dbSNP
rs573220224 1066 dbSNP
rs866388142 1069 dbSNP
rs1032488354 1076 dbSNP
rs1261625222 1084 dbSNP
rs1219182234 1087 dbSNP
rs906518818 1088 dbSNP
rs575691469 1094 dbSNP
rs748514018 1099 dbSNP
rs1242225049 1101 dbSNP
rs543167927 1102 dbSNP
rs149690061 1107 dbSNP
rs1011819851 1109 dbSNP
rs1437514210 1116 dbSNP
rs1390617598 1119 dbSNP
rs1198013477 1125 dbSNP
rs1025145100 1130 dbSNP
rs73234808 1131 dbSNP
rs1402738530 1134 dbSNP
rs1173833401 1141 dbSNP
rs541063900 1141 dbSNP
rs1184558462 1142 dbSNP
rs1188851448 1146 dbSNP
rs1245408995 1163 dbSNP
rs998746025 1165 dbSNP
rs1209774617 1168 dbSNP
rs926939752 1177 dbSNP
rs3755764 1181 dbSNP
rs1341601083 1182 dbSNP
rs1373654625 1183 dbSNP
rs1380810155 1196 dbSNP
rs1282221135 1204 dbSNP
rs1446946905 1212 dbSNP
rs1340833188 1220 dbSNP
rs752532548 1228 dbSNP
rs777370928 1232 dbSNP
rs1427709649 1238 dbSNP
rs1369453517 1242 dbSNP
rs1168625274 1243 dbSNP
rs533270826 1246 dbSNP
rs919771170 1248 dbSNP
rs1382942014 1255 dbSNP
rs1398068378 1262 dbSNP
rs770392717 1263 dbSNP
rs921007328 1272 dbSNP
rs1046928367 1280 dbSNP
rs114732917 1288 dbSNP
rs1239544729 1291 dbSNP
rs984280661 1292 dbSNP
rs908680340 1293 dbSNP
rs940210555 1305 dbSNP
rs1046612667 1308 dbSNP
rs943938686 1310 dbSNP
rs1207304171 1312 dbSNP
rs568896537 1323 dbSNP
rs899806571 1324 dbSNP
rs145484721 1325 dbSNP
rs549184129 1327 dbSNP
rs764448898 1334 dbSNP
rs893799512 1336 dbSNP
rs181457389 1337 dbSNP
rs892639721 1338 dbSNP
rs1042881986 1344 dbSNP
rs1255649790 1348 dbSNP
rs1009732406 1353 dbSNP
rs1317821798 1356 dbSNP
rs1405565697 1358 dbSNP
rs902997071 1358 dbSNP
rs1025092574 1362 dbSNP
rs1157350585 1387 dbSNP
rs148826339 1391 dbSNP
rs971034352 1399 dbSNP
rs1472555652 1404 dbSNP
rs1253095382 1405 dbSNP
rs117840599 1407 dbSNP
rs776185581 1409 dbSNP
rs958586928 1410 dbSNP
rs1019530335 1418 dbSNP
rs575484113 1422 dbSNP
rs145204732 1423 dbSNP
rs1027950716 1428 dbSNP
rs1288983392 1428 dbSNP
rs34880887 1428 dbSNP
rs996512439 1428 dbSNP
rs1292383825 1434 dbSNP
rs368022744 1434 dbSNP
rs867939959 1434 dbSNP
rs952496641 1434 dbSNP
rs1047321 1435 dbSNP
rs538956221 1436 dbSNP
rs557097452 1437 dbSNP
rs745567415 1440 dbSNP
rs1191774057 1444 dbSNP
rs1489595971 1446 dbSNP
rs1246482339 1451 dbSNP
rs1208339811 1453 dbSNP
rs1191563369 1457 dbSNP
rs1423076427 1475 dbSNP
rs1477450050 1477 dbSNP
rs1268499822 1478 dbSNP
rs1376805793 1478 dbSNP
rs1177071722 1479 dbSNP
rs1407949867 1484 dbSNP
rs575412417 1485 dbSNP
rs1464376246 1486 dbSNP
rs1300002287 1490 dbSNP
rs749096581 1490 dbSNP
rs1369087424 1491 dbSNP
rs938223905 1493 dbSNP
rs1433866358 1495 dbSNP
rs1389905263 1497 dbSNP
rs1322912264 1503 dbSNP
rs9829128 1505 dbSNP
rs1055791025 1507 dbSNP
rs555162119 1514 dbSNP
rs1435048494 1515 dbSNP
rs1388365107 1520 dbSNP
rs1188218577 1522 dbSNP
rs915219301 1528 dbSNP
rs1383610714 1538 dbSNP
rs943986575 1539 dbSNP
rs780485384 1543 dbSNP
rs1248440576 1547 dbSNP
rs1039995890 1549 dbSNP
rs1275744928 1552 dbSNP
rs921281018 1553 dbSNP
rs62281753 1561 dbSNP
rs1285771273 1562 dbSNP
rs1210726394 1563 dbSNP
rs1310762924 1567 dbSNP
rs762855218 1575 dbSNP
rs1227242859 1576 dbSNP
rs1365423684 1576 dbSNP
rs1261726641 1586 dbSNP
rs540625966 1593 dbSNP
rs1394711971 1601 dbSNP
rs1486962200 1605 dbSNP
rs892586827 1606 dbSNP
rs1009595056 1607 dbSNP
rs1262478484 1613 dbSNP
rs1468006794 1613 dbSNP
rs1167991275 1614 dbSNP
rs1490537465 1616 dbSNP
rs1040939787 1618 dbSNP
rs1185677886 1633 dbSNP
rs12489397 1635 dbSNP
rs996742464 1638 dbSNP
rs1182427285 1640 dbSNP
rs1486584375 1642 dbSNP
rs1028677399 1662 dbSNP
rs1203729883 1667 dbSNP
rs906671768 1668 dbSNP
rs185168940 1670 dbSNP
rs1034313965 1676 dbSNP
rs140704493 1677 dbSNP
rs963659606 1679 dbSNP
rs888101453 1691 dbSNP
rs1349095682 1692 dbSNP
rs1175064263 1696 dbSNP
rs1005657567 1697 dbSNP
rs1372483407 1699 dbSNP
rs1161723532 1706 dbSNP
rs375343085 1708 dbSNP
rs1015288891 1711 dbSNP
rs562487396 1718 dbSNP
rs145830840 1729 dbSNP
rs1409740154 1735 dbSNP
rs1026637694 1736 dbSNP
rs961149450 1739 dbSNP
rs1483119177 1744 dbSNP
rs148137066 1747 dbSNP
rs982503135 1748 dbSNP
rs912409135 1751 dbSNP
rs561220499 1753 dbSNP
rs1487930167 1769 dbSNP
rs1035115509 1780 dbSNP
rs190807499 1781 dbSNP
rs1405056330 1789 dbSNP
rs975357404 1795 dbSNP
rs921221849 1799 dbSNP
rs936586508 1803 dbSNP
rs1229519434 1807 dbSNP
rs1053745211 1810 dbSNP
rs913888433 1816 dbSNP
rs546547657 1818 dbSNP
rs1391638313 1819 dbSNP
rs1308148314 1831 dbSNP
rs1046437832 1834 dbSNP
rs915505908 1836 dbSNP
rs946727917 1842 dbSNP
rs58249013 1849 dbSNP
rs924019539 1851 dbSNP
rs1361871830 1854 dbSNP
rs944734917 1864 dbSNP
rs61708145 1865 dbSNP
rs900983106 1876 dbSNP
rs550847297 1877 dbSNP
rs539895187 1885 dbSNP
rs182041842 1888 dbSNP
rs899440244 1893 dbSNP
rs1353422287 1896 dbSNP
rs888395185 1896 dbSNP
rs559709916 1912 dbSNP
rs1026668985 1914 dbSNP
rs1487457065 1915 dbSNP
rs1348779032 1919 dbSNP
rs950997201 1923 dbSNP
rs536444865 1927 dbSNP
rs1305945983 1929 dbSNP
rs1003970886 1930 dbSNP
rs555148538 1936 dbSNP
rs1386209003 1940 dbSNP
rs1319594646 1948 dbSNP
rs1457705872 1957 dbSNP
rs1250892271 1983 dbSNP
rs528770456 1988 dbSNP
rs965156867 1989 dbSNP
rs1465169925 1992 dbSNP
rs1377672033 2000 dbSNP
rs1195166992 2002 dbSNP
rs1447237651 2003 dbSNP
rs78881569 2007 dbSNP
rs896832767 2008 dbSNP
rs1028145543 2012 dbSNP
rs1424949094 2015 dbSNP
rs957973646 2019 dbSNP
rs989333970 2022 dbSNP
rs1034752449 2030 dbSNP
rs1345865701 2035 dbSNP
rs1166271147 2037 dbSNP
rs1226503560 2040 dbSNP
rs959549809 2043 dbSNP
rs1436299582 2046 dbSNP
rs913918082 2059 dbSNP
rs945345152 2062 dbSNP
rs867996225 2064 dbSNP
rs1431272443 2071 dbSNP
rs1445066117 2076 dbSNP
rs1332165072 2077 dbSNP
rs982220966 2079 dbSNP
rs368121744 2088 dbSNP
rs539159032 2088 dbSNP
rs879144328 2108 dbSNP
rs879022219 2110 dbSNP
rs1375547955 2111 dbSNP
rs186191451 2112 dbSNP
rs1427431771 2118 dbSNP
rs765456505 2119 dbSNP
rs938095318 2124 dbSNP
rs552979208 2129 dbSNP
rs1168825807 2140 dbSNP
rs1248516943 2141 dbSNP
rs1055724290 2142 dbSNP
rs568336663 2150 dbSNP
rs899307302 2151 dbSNP
rs1321202849 2155 dbSNP
rs1187487035 2168 dbSNP
rs930894102 2174 dbSNP
rs1047974449 2179 dbSNP
rs189597441 2201 dbSNP
rs886773591 2212 dbSNP
rs1203033481 2213 dbSNP
rs1251842403 2213 dbSNP
rs1003918327 2216 dbSNP
rs1458897915 2218 dbSNP
rs545054065 2223 dbSNP
rs113323277 2224 dbSNP
rs11710926 2233 dbSNP
rs1282167631 2244 dbSNP
rs1447244028 2246 dbSNP
rs141914799 2255 dbSNP
rs1407525452 2257 dbSNP
rs996591709 2257 dbSNP
rs922038711 2265 dbSNP
rs1183238704 2270 dbSNP
rs551138328 2288 dbSNP
rs542410885 2290 dbSNP
rs561144089 2293 dbSNP
rs528543898 2298 dbSNP
rs989364527 2301 dbSNP
rs896801517 2305 dbSNP
rs1003188497 2307 dbSNP
rs1180640044 2310 dbSNP
rs1464564729 2318 dbSNP
rs1020790271 2324 dbSNP
rs1252602868 2329 dbSNP
rs1056131564 2331 dbSNP
rs1450047320 2332 dbSNP
rs966597062 2334 dbSNP
rs115430686 2337 dbSNP
rs1335224406 2337 dbSNP
rs1295126290 2340 dbSNP
rs565073370 2341 dbSNP
rs938112075 2343 dbSNP
rs1279592004 2347 dbSNP
rs1443928662 2350 dbSNP
rs1347691444 2353 dbSNP
rs1322451633 2356 dbSNP
rs1462353125 2357 dbSNP
rs371490677 2357 dbSNP
rs1157653509 2364 dbSNP
rs532363255 2365 dbSNP
rs1408852129 2371 dbSNP
rs1178961204 2372 dbSNP
rs1477170700 2374 dbSNP
rs1246405323 2387 dbSNP
rs1222583810 2393 dbSNP
rs1468782416 2415 dbSNP
rs1215276301 2427 dbSNP
rs1206775585 2431 dbSNP
rs1365632 2435 dbSNP
rs1307101256 2436 dbSNP
rs1225024656 2437 dbSNP
rs748555258 2437 dbSNP
rs1273917655 2440 dbSNP
rs968254272 2440 dbSNP
rs1441151958 2442 dbSNP
rs1373680783 2452 dbSNP
rs1457183974 2452 dbSNP
rs200327996 2456 dbSNP
rs72024864 2460 dbSNP
rs1412907199 2461 dbSNP
rs201475590 2462 dbSNP
rs35075143 2462 dbSNP
rs34460879 2463 dbSNP
rs1461611284 2464 dbSNP
rs1424512577 2468 dbSNP
rs1194526983 2470 dbSNP
rs757771678 2471 dbSNP
rs930757230 2472 dbSNP
rs1254660716 2473 dbSNP
rs966020188 2477 dbSNP
rs1485412116 2484 dbSNP
rs976114980 2485 dbSNP
rs780637241 2495 dbSNP
rs745376926 2506 dbSNP
rs150219246 2508 dbSNP
rs1277237902 2509 dbSNP
rs181242588 2511 dbSNP
rs879159460 2517 dbSNP
rs1186570518 2524 dbSNP
rs1425219887 2525 dbSNP
rs944965824 2527 dbSNP
rs1291188743 2550 dbSNP
rs1041135942 2559 dbSNP
rs548460595 2561 dbSNP
rs1358685576 2562 dbSNP
rs1174267082 2590 dbSNP
rs997014041 2591 dbSNP
rs909676356 2592 dbSNP
rs1388613455 2593 dbSNP
rs1168188698 2598 dbSNP
rs539916397 2603 dbSNP
rs546716400 2604 dbSNP
rs1188228193 2605 dbSNP
rs1482214251 2606 dbSNP
rs1256205720 2607 dbSNP
rs1010734874 2614 dbSNP
rs1349403002 2619 dbSNP
rs1431816430 2626 dbSNP
rs1300106026 2633 dbSNP
rs1272121172 2636 dbSNP
rs1020730059 2640 dbSNP
rs966621479 2643 dbSNP
rs1003438332 2645 dbSNP
rs146434073 2645 dbSNP
rs1047330 2647 dbSNP
rs959365631 2648 dbSNP
rs1227108977 2656 dbSNP
rs1379008360 2657 dbSNP
rs991312255 2666 dbSNP
rs1056098672 2667 dbSNP
rs920715771 2669 dbSNP
rs190512266 2671 dbSNP
rs1462642137 2676 dbSNP
rs1373467152 2680 dbSNP
rs1172186109 2691 dbSNP
rs868457198 2702 dbSNP
rs1422004734 2703 dbSNP
rs571404538 2704 dbSNP
rs748909573 2717 dbSNP
rs1486390254 2720 dbSNP
rs1248961077 2723 dbSNP
rs1194896357 2727 dbSNP
rs538632958 2732 dbSNP
rs944973831 2741 dbSNP
rs1043497426 2743 dbSNP
rs1264702145 2748 dbSNP
rs1334606262 2749 dbSNP
rs1040603552 2750 dbSNP
rs1294479557 2756 dbSNP
rs768383711 2759 dbSNP
rs1193547225 2761 dbSNP
rs1348730481 2767 dbSNP
rs1287756973 2769 dbSNP
rs1392188891 2774 dbSNP
rs903997821 2777 dbSNP
rs1291991939 2779 dbSNP
rs183844766 2779 dbSNP
rs1430660624 2781 dbSNP
rs1393420157 2787 dbSNP
rs1165629848 2790 dbSNP
rs932295976 2801 dbSNP
rs1409133986 2805 dbSNP
rs1171132611 2806 dbSNP
rs138766419 2816 dbSNP
rs542922224 2822 dbSNP
rs1031249112 2824 dbSNP
rs554439183 2828 dbSNP
rs368867255 2832 dbSNP
rs997770158 2833 dbSNP
rs1042219583 2839 dbSNP
rs1327622009 2843 dbSNP
rs1029372557 2844 dbSNP
rs186711703 2846 dbSNP
rs200377206 2862 dbSNP
rs755797018 2874 dbSNP
rs1331562827 2880 dbSNP
rs1337612599 2883 dbSNP
rs556221291 2884 dbSNP
rs192434758 2887 dbSNP
rs565034861 2888 dbSNP
rs1370008746 2889 dbSNP
rs777614984 2909 dbSNP
rs535771918 2918 dbSNP
rs1386432161 2921 dbSNP
rs1157924354 2925 dbSNP
rs1012282275 2937 dbSNP
rs1365001791 2946 dbSNP
rs532473920 2950 dbSNP
rs918502552 2956 dbSNP
rs1254023023 2961 dbSNP
rs1215209613 2964 dbSNP
rs1463816475 2966 dbSNP
rs1261724592 2974 dbSNP
rs1269001640 2982 dbSNP
rs767493295 2992 dbSNP
rs983514808 2997 dbSNP
rs908057574 3000 dbSNP
rs544160405 3002 dbSNP
rs966204123 3004 dbSNP
rs1352996562 3006 dbSNP
rs1254277816 3011 dbSNP
rs939232328 3015 dbSNP
rs1453771508 3020 dbSNP
rs1056392520 3021 dbSNP
rs916204405 3022 dbSNP
rs1246480621 3027 dbSNP
rs1324436436 3032 dbSNP
rs183744627 3035 dbSNP
rs947765308 3042 dbSNP
rs187931895 3043 dbSNP
rs1160652418 3048 dbSNP
rs1170222002 3049 dbSNP
rs1244355901 3050 dbSNP
rs1043852421 3054 dbSNP
rs191266838 3064 dbSNP
rs772962480 3066 dbSNP
rs548844728 3074 dbSNP
rs1241869481 3078 dbSNP
rs1194548111 3081 dbSNP
rs1049408556 3082 dbSNP
rs143019075 3083 dbSNP
rs1210330890 3094 dbSNP
rs1407011958 3100 dbSNP
rs1282785746 3104 dbSNP
rs1226431333 3115 dbSNP
rs1321574303 3117 dbSNP
rs182689717 3119 dbSNP
rs1042086661 3120 dbSNP
rs537675262 3121 dbSNP
rs902018688 3127 dbSNP
rs1310982365 3128 dbSNP
rs1447295646 3129 dbSNP
rs552848235 3130 dbSNP
rs1003415210 3132 dbSNP
rs1314386745 3134 dbSNP
rs1056690982 3135 dbSNP
rs1419291128 3140 dbSNP
rs1029264326 3141 dbSNP
rs147450474 3142 dbSNP
rs1187818039 3144 dbSNP
rs1016755477 3146 dbSNP
rs538747132 3148 dbSNP
rs1203319475 3159 dbSNP
rs962142412 3162 dbSNP
rs1357928540 3173 dbSNP
rs1012153637 3175 dbSNP
rs1341207395 3193 dbSNP
rs1291409164 3195 dbSNP
rs778289098 3199 dbSNP
rs972127952 3210 dbSNP
rs1294554929 3228 dbSNP
rs1438934643 3248 dbSNP
rs556647321 3251 dbSNP
rs1236749024 3256 dbSNP
rs1412035118 3256 dbSNP
rs1392706509 3258 dbSNP
rs960541809 3259 dbSNP
rs1475797552 3267 dbSNP
rs992463044 3269 dbSNP
rs1180029928 3275 dbSNP
rs577705713 3283 dbSNP
rs1184512239 3284 dbSNP
rs1439395508 3285 dbSNP
rs1270985640 3286 dbSNP
rs947703283 3303 dbSNP
rs1433346909 3305 dbSNP
rs1274523422 3308 dbSNP
rs1221639586 3314 dbSNP
rs1371940832 3318 dbSNP
rs1279818250 3330 dbSNP
rs764428793 3332 dbSNP
rs1443857801 3335 dbSNP
rs1369283471 3344 dbSNP
rs1325570952 3348 dbSNP
rs1004981227 3354 dbSNP
rs1014977837 3355 dbSNP
rs371674667 3358 dbSNP
rs751952695 3367 dbSNP
rs1400236361 3369 dbSNP
rs1456499099 3370 dbSNP
rs1160538130 3372 dbSNP
rs1161360187 3375 dbSNP
rs1389874813 3376 dbSNP
rs924943044 3378 dbSNP
rs1192716723 3383 dbSNP
rs1468741860 3388 dbSNP
rs1254857105 3392 dbSNP
rs187346332 3401 dbSNP
rs540283359 3406 dbSNP
rs1284295856 3407 dbSNP
rs976312546 3408 dbSNP
rs757498745 3410 dbSNP
rs1445571931 3415 dbSNP
rs1345222267 3417 dbSNP
rs1302219528 3433 dbSNP
rs1313056145 3436 dbSNP
rs1373610944 3438 dbSNP
rs1287684799 3439 dbSNP
rs1328566236 3439 dbSNP
rs536669954 3447 dbSNP
rs1341714831 3449 dbSNP
rs1430583204 3457 dbSNP
rs1345892915 3475 dbSNP
rs372271376 3476 dbSNP
rs539992698 3477 dbSNP
rs1319146082 3480 dbSNP
rs1201080494 3489 dbSNP
rs191758790 3490 dbSNP
rs1454584778 3499 dbSNP
rs750912344 3509 dbSNP
rs377157024 3514 dbSNP
rs747487379 3534 dbSNP
rs977723776 3535 dbSNP
rs1422315030 3537 dbSNP
rs185434451 3540 dbSNP
rs1373729622 3543 dbSNP
rs939083772 3545 dbSNP
rs1478067694 3547 dbSNP
rs1217383003 3548 dbSNP
rs1016228913 3552 dbSNP
rs189907878 3554 dbSNP
rs897838795 3567 dbSNP
rs993514637 3572 dbSNP
rs1421184524 3577 dbSNP
rs1293831768 3578 dbSNP
rs1464947207 3590 dbSNP
rs1056321534 3591 dbSNP
rs755717427 3599 dbSNP
rs562871753 3602 dbSNP
rs894951165 3603 dbSNP
rs947967471 3606 dbSNP
rs1403846054 3613 dbSNP
rs139797644 3623 dbSNP
rs1393943768 3639 dbSNP
rs1048975925 3640 dbSNP
rs1340669438 3641 dbSNP
rs887780777 3644 dbSNP
rs113271132 3649 dbSNP
rs1360684350 3650 dbSNP
rs1276917998 3671 dbSNP
rs1427688010 3673 dbSNP
rs1317646593 3674 dbSNP
rs1195711533 3675 dbSNP
rs1473968985 3691 dbSNP
rs541895645 3692 dbSNP
rs779687997 3696 dbSNP
rs1015332457 3699 dbSNP
rs1372336165 3701 dbSNP
rs901956911 3709 dbSNP
rs997984368 3712 dbSNP
rs774032450 3714 dbSNP
rs1308446042 3715 dbSNP
rs1298435221 3729 dbSNP
rs1231941622 3731 dbSNP
rs1029174527 3743 dbSNP
rs1023970083 3744 dbSNP
rs1416868428 3744 dbSNP
rs766884725 3744 dbSNP
rs1263989857 3745 dbSNP
rs979765780 3757 dbSNP
rs953512787 3760 dbSNP
rs990363784 3768 dbSNP
rs1461330300 3782 dbSNP
rs1195721972 3783 dbSNP
rs71627891 3795 dbSNP
rs1459773818 3796 dbSNP
rs201265461 3797 dbSNP
rs987868819 3802 dbSNP
rs1187980650 3804 dbSNP
rs1021869789 3805 dbSNP
rs933478725 3809 dbSNP
rs1176452475 3811 dbSNP
rs1176240057 3817 dbSNP
rs1481175920 3820 dbSNP
rs1050656605 3832 dbSNP
rs967593383 3833 dbSNP
rs942265912 3834 dbSNP
rs977755009 3836 dbSNP
rs1379161681 3843 dbSNP
rs923583288 3844 dbSNP
rs1334022979 3854 dbSNP
rs939134859 3855 dbSNP
rs1392132834 3858 dbSNP
rs1464228946 3870 dbSNP
rs1037930458 3878 dbSNP
rs1438642326 3882 dbSNP
rs1393722614 3883 dbSNP
rs1165562463 3885 dbSNP
rs1459032060 3890 dbSNP
rs897807714 3894 dbSNP
rs1157952267 3896 dbSNP
rs1171696836 3899 dbSNP
rs1360578631 3901 dbSNP
rs1240424526 3912 dbSNP
rs1192214907 3914 dbSNP
rs1468315056 3914 dbSNP
rs560834539 3916 dbSNP
rs1212129269 3921 dbSNP
rs1401351524 3923 dbSNP
rs993483634 3945 dbSNP
rs138820154 3963 dbSNP
rs1295845107 3966 dbSNP
rs202138503 3966 dbSNP
rs11282181 3967 dbSNP
rs56128789 3967 dbSNP
rs63027961 3968 dbSNP
rs1387872604 3980 dbSNP
rs916426822 3982 dbSNP
rs947832621 3983 dbSNP
rs1310877507 3985 dbSNP
rs1382141111 3987 dbSNP
rs895943388 3988 dbSNP
rs1048922453 3992 dbSNP
rs527992587 4003 dbSNP
rs1454145507 4005 dbSNP
rs1396016611 4011 dbSNP
rs1287066050 4017 dbSNP
rs1013419607 4020 dbSNP
rs1261145935 4025 dbSNP
rs1205853874 4034 dbSNP
rs1224489134 4037 dbSNP
rs1489311868 4039 dbSNP
rs1278514538 4045 dbSNP
rs940576163 4048 dbSNP
rs749005703 4050 dbSNP
rs901811780 4053 dbSNP
rs1356166003 4060 dbSNP
rs768348350 4077 dbSNP
rs778361101 4083 dbSNP
rs773755471 4091 dbSNP
rs1023433655 4096 dbSNP
rs552762349 4097 dbSNP
rs1324671810 4098 dbSNP
rs559273031 4101 dbSNP
rs1050900956 4103 dbSNP
rs747985920 4104 dbSNP
rs564684861 4126 dbSNP
rs532215909 4128 dbSNP
rs1433673516 4135 dbSNP
rs143716060 4136 dbSNP
rs967626028 4148 dbSNP
rs796114917 4163 dbSNP
rs756076601 4165 dbSNP
rs1269188273 4174 dbSNP
rs1194483459 4183 dbSNP
rs1431278491 4184 dbSNP
rs1030680568 4185 dbSNP
rs923014815 4200 dbSNP
rs1486087097 4201 dbSNP
rs1192584851 4212 dbSNP
rs960618885 4221 dbSNP
rs1337167801 4222 dbSNP
rs568894039 4224 dbSNP
rs916355266 4227 dbSNP
rs969119709 4232 dbSNP
rs1156239398 4235 dbSNP
rs536241018 4235 dbSNP
rs984652071 4236 dbSNP
rs1413804819 4241 dbSNP
rs1176288741 4242 dbSNP
rs1206560387 4242 dbSNP
rs1335776839 4242 dbSNP
rs1340759690 4242 dbSNP
rs3215276 4242 dbSNP
rs796071035 4242 dbSNP
rs1239470720 4244 dbSNP
rs1179893714 4247 dbSNP
rs1359352600 4249 dbSNP
rs1458860509 4250 dbSNP
rs369826348 4251 dbSNP
rs75249985 4252 dbSNP
rs1356403066 4253 dbSNP
rs28457644 4253 dbSNP
rs77944524 4256 dbSNP
rs28602932 4257 dbSNP
rs3830548 4258 dbSNP
rs56048310 4258 dbSNP
rs75032779 4258 dbSNP
rs1491286249 4266 dbSNP
rs13099528 4268 dbSNP
rs71627892 4268 dbSNP
rs777018356 4268 dbSNP
rs1238256645 4269 dbSNP
rs1285395353 4270 dbSNP
rs1406073601 4271 dbSNP
rs1415988845 4274 dbSNP
rs1322466158 4278 dbSNP
rs909028504 4281 dbSNP
rs1469757908 4284 dbSNP
rs193273356 4286 dbSNP
rs72991064 4287 dbSNP
rs1458924625 4288 dbSNP
rs923298914 4295 dbSNP
rs1251108044 4302 dbSNP
rs1487483175 4304 dbSNP
rs1212969828 4305 dbSNP
rs1451700541 4310 dbSNP
rs369512837 4315 dbSNP
rs1050439240 4316 dbSNP
rs1221723760 4318 dbSNP
rs372174241 4319 dbSNP
rs762128616 4329 dbSNP
rs144081307 4330 dbSNP
rs769984850 4332 dbSNP
rs1325849970 4336 dbSNP
rs1437758444 4339 dbSNP
rs1043223219 4341 dbSNP
rs576608693 4342 dbSNP
rs1406587475 4346 dbSNP
rs1381227851 4351 dbSNP
rs59930552 4352 dbSNP
rs1036314987 4359 dbSNP
rs960319147 4370 dbSNP
rs556613543 4373 dbSNP
rs1044891370 4378 dbSNP
rs376101972 4380 dbSNP
rs1013703966 4393 dbSNP
rs537889335 4394 dbSNP
rs1286343180 4405 dbSNP
rs1402995031 4422 dbSNP
rs115408340 4433 dbSNP
rs984516653 4434 dbSNP
rs1346204391 4436 dbSNP
rs1303049676 4441 dbSNP
rs1308868291 4450 dbSNP
rs909052845 4456 dbSNP
rs560492204 4459 dbSNP
rs1370434588 4460 dbSNP
rs562077990 4469 dbSNP
rs1230063941 4474 dbSNP
rs760571813 4479 dbSNP
rs1310690633 4482 dbSNP
rs956649700 4483 dbSNP
rs923214249 4485 dbSNP
rs753900613 4489 dbSNP
rs373089318 4495 dbSNP
rs1212994785 4499 dbSNP
rs148663665 4501 dbSNP
rs546540166 4503 dbSNP
rs1433548108 4510 dbSNP
rs1196338118 4512 dbSNP
rs1184682718 4524 dbSNP
rs1231989380 4532 dbSNP
rs933237064 4535 dbSNP
rs954542570 4536 dbSNP
rs1477220941 4537 dbSNP
rs985875590 4541 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucUGGGGAGGAGGUAGg 5'
            |:|:||:||||||| 
Target 5' --AUCUCUUCUCCAUCa 3'
 		1 - 15
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000446041.2 | 3UTR | AUCUCUUCUCCAUCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
141 hsa-miR-4534 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT087131 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT179641 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT243304 SLC25A36 solute carrier family 25 member 36 2 2
MIRT325574 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT448776 GNA13 G protein subunit alpha 13 2 2
MIRT451456 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT452150 PPP2R1B protein phosphatase 2 scaffold subunit Abeta 2 2
MIRT454199 HLA-A major histocompatibility complex, class I, A 2 2
MIRT455984 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT456058 SLC25A28 solute carrier family 25 member 28 2 2
MIRT457082 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT457278 ALDH9A1 aldehyde dehydrogenase 9 family member A1 2 2
MIRT457361 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT457396 CAMK2A calcium/calmodulin dependent protein kinase II alpha 2 2
MIRT458817 ZNF843 zinc finger protein 843 2 2
MIRT459697 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460346 ARL14EP ADP ribosylation factor like GTPase 14 effector protein 2 2
MIRT462713 MAPK13 mitogen-activated protein kinase 13 2 2
MIRT464278 VASH1 vasohibin 1 2 2
MIRT465634 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT465772 TMOD3 tropomodulin 3 2 2
MIRT466414 TFDP1 transcription factor Dp-1 2 2
MIRT467122 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 8
MIRT467475 SMYD1 SET and MYND domain containing 1 2 4
MIRT468462 SET SET nuclear proto-oncogene 2 2
MIRT468618 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT468835 RRM2 ribonucleotide reductase regulatory subunit M2 2 4
MIRT470890 PLXND1 plexin D1 2 2
MIRT473226 SMCR7L mitochondrial elongation factor 1 2 4
MIRT473858 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474975 KCND3 potassium voltage-gated channel subfamily D member 3 2 2
MIRT475858 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT478569 CTNND1 catenin delta 1 2 2
MIRT479347 CEP97 centrosomal protein 97 2 2
MIRT479910 CCDC117 coiled-coil domain containing 117 2 4
MIRT480122 CALR calreticulin 2 2
MIRT480892 BCL9L B-cell CLL/lymphoma 9 like 2 2
MIRT481149 AVL9 AVL9 cell migration associated 2 6
MIRT481527 ARL5B ADP ribosylation factor like GTPase 5B 2 10
MIRT481896 ANKRD40 ankyrin repeat domain 40 2 2
MIRT490138 FN3K fructosamine 3 kinase 2 4
MIRT490329 ANK1 ankyrin 1 2 4
MIRT491472 TMEM214 transmembrane protein 214 2 2
MIRT503552 TIGIT T-cell immunoreceptor with Ig and ITIM domains 2 4
MIRT504413 TUBA1B tubulin alpha 1b 2 4
MIRT508207 SLC35E1 solute carrier family 35 member E1 2 2
MIRT508333 SLC37A4 solute carrier family 37 member 4 2 6
MIRT516381 TRAF3IP2 TRAF3 interacting protein 2 2 4
MIRT518549 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT522545 MED28 mediator complex subunit 28 2 6
MIRT522592 MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1 like 2 2
MIRT522923 KAT6A lysine acetyltransferase 6A 2 4
MIRT525937 C11orf74 chromosome 11 open reading frame 74 2 2
MIRT527021 PABPN1L poly(A) binding protein nuclear 1 like, cytoplasmic 2 2
MIRT530396 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT530660 TRIM56 tripartite motif containing 56 2 2
MIRT531625 TM4SF5 transmembrane 4 L six family member 5 2 4
MIRT532703 TCN2 transcobalamin 2 2 4
MIRT540173 MB21D1 Mab-21 domain containing 1 2 2
MIRT540756 UTP6 UTP6, small subunit processome component 2 2
MIRT541966 ZNF485 zinc finger protein 485 2 2
MIRT542738 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT543090 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT550687 YARS tyrosyl-tRNA synthetase 2 2
MIRT553466 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT559980 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT561084 LLPH LLP homolog, long-term synaptic facilitation 2 2
MIRT561738 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT569872 KLK10 kallikrein related peptidase 10 2 2
MIRT570264 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT573431 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT573874 PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 2 2
MIRT576905 Poteg POTE ankyrin domain family, member G 2 2
MIRT607934 ANG angiogenin 2 2
MIRT609472 RPL7L1 ribosomal protein L7 like 1 2 4
MIRT612179 EMC3 ER membrane protein complex subunit 3 2 2
MIRT613428 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613746 GPR155 G protein-coupled receptor 155 2 2
MIRT615034 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT615565 JPH2 junctophilin 2 2 2
MIRT615937 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT616643 LRAT lecithin retinol acyltransferase 2 4
MIRT630890 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636542 FAM126B family with sequence similarity 126 member B 2 2
MIRT641392 NUBPL nucleotide binding protein like 2 2
MIRT641410 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT643184 HYPK huntingtin interacting protein K 2 2
MIRT652600 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT653974 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT655692 NUDT3 nudix hydrolase 3 2 2
MIRT660734 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 4
MIRT661604 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT663284 ZNF675 zinc finger protein 675 2 2
MIRT666337 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT666636 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT667125 OCIAD2 OCIA domain containing 2 2 2
MIRT670412 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671119 ZNF573 zinc finger protein 573 2 2
MIRT671152 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671336 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671867 ZNF429 zinc finger protein 429 2 2
MIRT671972 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672062 KIAA0930 KIAA0930 2 2
MIRT672652 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672671 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672768 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672927 LRRC2 leucine rich repeat containing 2 2 2
MIRT673156 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673270 RUNDC1 RUN domain containing 1 2 2
MIRT673329 THAP1 THAP domain containing 1 2 2
MIRT673348 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673664 ZNF440 zinc finger protein 440 2 2
MIRT673901 DCTN6 dynactin subunit 6 2 2
MIRT674399 MYCBP MYC binding protein 2 2
MIRT674523 PRR23A proline rich 23A 2 2
MIRT674831 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675064 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675078 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675123 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679399 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT686608 TMEM70 transmembrane protein 70 2 2
MIRT690371 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT694464 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT695706 OLA1 Obg like ATPase 1 2 2
MIRT696846 WDR13 WD repeat domain 13 2 2
MIRT700894 PER2 period circadian clock 2 2 2
MIRT701924 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT704918 CCDC36 coiled-coil domain containing 36 2 2
MIRT706211 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706546 GJD2 gap junction protein delta 2 2 2
MIRT706727 RFK riboflavin kinase 2 2
MIRT707366 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT707416 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710646 GLUL glutamate-ammonia ligase 2 2
MIRT712298 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713709 HIST3H2BB histone cluster 3 H2B family member b 2 2
MIRT713751 SLC9A8 solute carrier family 9 member A8 2 2
MIRT716423 VPS53 VPS53, GARP complex subunit 2 2
MIRT717169 UCHL3 ubiquitin C-terminal hydrolase L3 2 2
MIRT718877 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT720096 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4534 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4534 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4534 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4534 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4534 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4534 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-mir-4534 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4534 Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-4534 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4534 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4534 Platinum 23939 resistant tissue
hsa-miR-4534 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4534 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)

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