miRTarBase - #MIRT248820


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pre-miRNA Information
pre-miRNA hsa-mir-203b   
Genomic Coordinates chr14: 104117418 - 104117503
Description Homo sapiens miR-203b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-203b-3p
Sequence 54| UUGAACUGUUAAGAACCACUGGA |76
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 11 14 - 104117440 28550310 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1444131167 3 dbSNP
rs1307766631 8 dbSNP
rs527418519 12 dbSNP
rs771545143 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SESN2   
Synonyms HI95, SES2, SEST2
Description sestrin 2
Transcript NM_031459   
Expression
Putative miRNA Targets on SESN2
3'UTR of SESN2
(miRNA target sites are highlighted)		 
>SESN2|NM_031459|3'UTR
   1 CTCCTGAGCAGGACCTGGGCCCGGTTCAGCTCCCCACAAGGACTTCTCTGTCTGGAGACAGCCCCAGACCCTTTTGTGTC
  81 CCATGCCCACCCTCCCCACGCTGCAGTGGGCTTGTGTGTGATGTGCAGTCCCGAAGCCACACCCTCCCTTTTCCTCACTG
 161 GAATGGACAGTTCATTGCACTGACTCTGGGATCTCAGCCCTGCTCCTGGGAGCTGGAAGAGCACTTGGAGATCCTAAGGG
 241 ACCACACCCTTCCTCCTTCCCCTGCCCACAGAGGCAGAGGGCACAGGAAAGAAGCCGGGCCAAGCTCGGAATTAATGTGC
 321 CACAAGTGTTGTGGCCTTCCTGAACTGGGAAGTCCCTGGCTGGCCCCCGGGGGAGAGGGGCAAATGCCTCCGGGACTGAC
 401 ACTCCAGGCAGCTTTGCCTTCTCTCCCCTGTCATTTCCAGATTTCATTACCTCCTACTTGCCATTCACCCATCAATGTGA
 481 AAGTCAGGGTCACAGCTGGTCTGTGTGTCCAGTTCCCTAAAAGCCTGTTCTGTTGGGCAGCCTGAGGCTGTTGCCCGAAT
 561 CCTAGTTCAGTTTTTTGACTTCCTTTGCCCTTTTTCCCTTTTCTCCATGCTTAATGGTGTGAGGCGTCAGGAGAGAGGCC
 641 AAGTACATAAAAAAAAAAAAAGCAGATTATCTCTAGAGAGTTTGAGCCTTTGCTGGTCACATTGCCTTCTGAAGAGGAGG
 721 GAGTATTAGATTATAAATCCTCTTTATTTTGGTCCTTTATGCTTGAGGTTCCAACCTGGAGCCACAGTGTGTGAGAGGAG
 801 GAGGAGAGGGAGAATTCTGTTCTCCCAGAGCTGCACCTGCCTCGCAGAGGCCAGCACCCCACTCTCCTGCCTCCAGTGGC
 881 CCTGCCGCAGATGTCTCCCAAAAAGTTGAGCCTTTCTAGATGGCTTAGGTGGCACCATGGCTCAGCAGGAGGGGCGGGAG
 961 GCACCAGGGTTCTTGTTTGGACCCTGCCCCTGGGCCATGGCCAGGTGACCATGGCTACATTGCCAAACCTCTGACTGCCA
1041 CAGCTGCAGACTGAGAGGGTGGGTCTGAGTCCCCACAATGTCTGAAGCTGCCCCTGGGATTCTCAGGCCAACCTGCCAAC
1121 AGCAAGCGGATTTTCTTGCAAGATCAGGGACCCCATTTCTGCAGCCAGTGTCTCCTGGGTGCCTTCTGAGGACTCCCACC
1201 CCCATCCCAGTATCTCATCTGTCCCCTCTCCTGGGGCTTAAGTGGGTTGCTTCCAGGCAGAAGCAGCCAAGGACCGATTC
1281 CAGGCACTTTCTGTAGCAAATGACTGTGAATTACGACTTCTCTTGCCCTTCTTCTAGCAGTCTGTGCCTCCTCTCTGACC
1361 AGTTTGGAGGGCACTGAAGAAAGGCAAGGGCCGTGCTGCTGCTGGGCGGGGCAGGAGAGGAGCCTGGCCAGTGTGCCACA
1441 TTAAATACCCGTGCAGGCGCGGAGAAGCAACCGGCACCCCCTTCCGGCCTGAAAGCCCTCCCTGCAAGAAGGTGTGCAGG
1521 AGAGAAGAGGCCCCGGCATGGGGATCTGGGTTCTAGAGGGCATGTGATGACTGTAAATGTTCACTGGGTGGGTAGGGAGT
1601 GGTATCCAGTGTTCAAGTGCAGAAATCTTTGGCTTTGCTACCAGTTCCATATGATGAGAAATAAACGTTCGCTGAGGTTT
1681 TGTTTCATAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agGUCACCAAGAAUUGUCAAGUu 5'
            || |||   | :|||||||| 
Target 5' ctCACTGG-AATGGACAGTTCAt 3'
 154 - 175 156.00 -14.50
2 
miRNA  3' aggucACCAAGA--AUUGUCAAGuu 5'
               ||| |:|  || ||||||  
Target 5' atcttTGGCTTTGCTACCAGTTCca 3'
 1625 - 1649 140.00 -9.00
3 
miRNA  3' agGUC-ACCA---AGAAUUGUCAAGuu 5'
            ||| ||||   | |   ||||||  
Target 5' caCAGCTGGTCTGTGTGTCCAGTTCcc 3'
 491 - 517 133.00 -12.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26636402 20 COSMIC
COSN30508915 24 COSMIC
COSN30485371 95 COSMIC
COSN30027538 131 COSMIC
COSN5740424 188 COSMIC
COSN24325465 571 COSMIC
COSN1102439 662 COSMIC
COSN20094622 662 COSMIC
COSN17181560 787 COSMIC
COSN29796172 1091 COSMIC
COSN28202125 1180 COSMIC
COSN27800418 1536 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769395715 4 dbSNP
rs547652634 5 dbSNP
rs370925800 10 dbSNP
rs766661062 18 dbSNP
rs757483688 23 dbSNP
rs375396916 24 dbSNP
rs767831374 30 dbSNP
rs752886912 31 dbSNP
rs758274242 32 dbSNP
rs1179983876 35 dbSNP
rs1257212704 38 dbSNP
rs756219286 40 dbSNP
rs777781076 41 dbSNP
rs1187940130 43 dbSNP
rs1261574951 44 dbSNP
rs779852360 46 dbSNP
rs961534163 49 dbSNP
rs1168889678 51 dbSNP
rs992991731 53 dbSNP
rs917436163 57 dbSNP
rs949163716 60 dbSNP
rs980393843 62 dbSNP
rs1291423893 68 dbSNP
rs1288225559 72 dbSNP
rs926281645 77 dbSNP
rs1401645582 79 dbSNP
rs950275639 81 dbSNP
rs936351159 87 dbSNP
rs1344520352 90 dbSNP
rs140893776 92 dbSNP
rs1221299098 100 dbSNP
rs533051045 101 dbSNP
rs1248383828 103 dbSNP
rs1053668986 115 dbSNP
rs892382959 119 dbSNP
rs1466119284 126 dbSNP
rs1181555670 133 dbSNP
rs549585881 134 dbSNP
rs1264304457 141 dbSNP
rs1480268657 147 dbSNP
rs116173499 165 dbSNP
rs887362317 174 dbSNP
rs1427454250 180 dbSNP
rs945181719 182 dbSNP
rs1040938240 190 dbSNP
rs1383565290 196 dbSNP
rs1421413970 198 dbSNP
rs1298653347 212 dbSNP
rs190182009 226 dbSNP
rs1402812583 232 dbSNP
rs1294929594 244 dbSNP
rs1367817449 257 dbSNP
rs1163844029 260 dbSNP
rs901239945 262 dbSNP
rs1038462090 272 dbSNP
rs899562098 290 dbSNP
rs1242940450 296 dbSNP
rs1399455413 297 dbSNP
rs996962059 298 dbSNP
rs17163103 304 dbSNP
rs1029488419 308 dbSNP
rs1488919449 321 dbSNP
rs1176733916 325 dbSNP
rs1236429357 346 dbSNP
rs1441532615 348 dbSNP
rs890993831 356 dbSNP
rs1437679758 360 dbSNP
rs1009359325 363 dbSNP
rs781326789 369 dbSNP
rs566076103 370 dbSNP
rs1005974810 371 dbSNP
rs1378451835 372 dbSNP
rs1053101 374 dbSNP
rs534973944 381 dbSNP
rs1227015424 385 dbSNP
rs1015839231 386 dbSNP
rs1245075321 391 dbSNP
rs958806445 392 dbSNP
rs780090320 393 dbSNP
rs1347982529 398 dbSNP
rs767942260 402 dbSNP
rs1459149558 403 dbSNP
rs1242479090 404 dbSNP
rs992021258 405 dbSNP
rs1268643281 422 dbSNP
rs992941145 424 dbSNP
rs917341627 425 dbSNP
rs950161283 427 dbSNP
rs1168108623 428 dbSNP
rs1401937834 428 dbSNP
rs1201473660 441 dbSNP
rs1024459170 444 dbSNP
rs1335468929 446 dbSNP
rs557937669 447 dbSNP
rs982959288 450 dbSNP
rs1286385444 454 dbSNP
rs980467321 455 dbSNP
rs908769593 463 dbSNP
rs1214284153 468 dbSNP
rs1188582267 472 dbSNP
rs1239267695 474 dbSNP
rs1468707646 476 dbSNP
rs578074446 477 dbSNP
rs926367062 478 dbSNP
rs553697397 486 dbSNP
rs17357180 488 dbSNP
rs1413279693 496 dbSNP
rs989583981 500 dbSNP
rs913814134 512 dbSNP
rs754907589 531 dbSNP
rs1174649179 538 dbSNP
rs1191185402 543 dbSNP
rs1425392282 557 dbSNP
rs1477927457 558 dbSNP
rs1402028660 561 dbSNP
rs1053107 578 dbSNP
rs899530091 579 dbSNP
rs1040886324 582 dbSNP
rs1336723959 583 dbSNP
rs1360211605 589 dbSNP
rs1333651895 592 dbSNP
rs900976890 596 dbSNP
rs1408635216 614 dbSNP
rs747880796 615 dbSNP
rs1274396594 618 dbSNP
rs771914639 620 dbSNP
rs1221679205 626 dbSNP
rs574064287 627 dbSNP
rs543072164 635 dbSNP
rs1214234204 640 dbSNP
rs1201222466 644 dbSNP
rs1265060498 645 dbSNP
rs1280955259 645 dbSNP
rs1436318093 647 dbSNP
rs768412748 648 dbSNP
rs1280523042 649 dbSNP
rs1362832090 649 dbSNP
rs1419592845 649 dbSNP
rs1491045342 649 dbSNP
rs200339046 649 dbSNP
rs3831951 649 dbSNP
rs57658162 649 dbSNP
rs747816308 649 dbSNP
rs932416959 650 dbSNP
rs1051247950 652 dbSNP
rs1016036309 654 dbSNP
rs1197947074 654 dbSNP
rs897400989 657 dbSNP
rs1352987231 661 dbSNP
rs1491288762 661 dbSNP
rs1491518075 662 dbSNP
rs1375922998 663 dbSNP
rs1288007496 668 dbSNP
rs890884533 668 dbSNP
rs1009326623 672 dbSNP
rs1020764264 673 dbSNP
rs1264856268 674 dbSNP
rs1198999913 675 dbSNP
rs903764839 675 dbSNP
rs772984666 677 dbSNP
rs1231809352 679 dbSNP
rs1183331008 683 dbSNP
rs1439682721 686 dbSNP
rs980682820 692 dbSNP
rs1000768226 702 dbSNP
rs749723930 703 dbSNP
rs1420723256 706 dbSNP
rs1162984195 711 dbSNP
rs559774801 717 dbSNP
rs1033009242 721 dbSNP
rs1308102672 725 dbSNP
rs768845539 731 dbSNP
rs958063929 740 dbSNP
rs958915959 743 dbSNP
rs1376276943 753 dbSNP
rs528758172 775 dbSNP
rs1444571991 788 dbSNP
rs1311412835 792 dbSNP
rs1354269248 795 dbSNP
rs1403006342 795 dbSNP
rs147539738 796 dbSNP
rs1210048562 818 dbSNP
rs1256964642 824 dbSNP
rs1456069307 828 dbSNP
rs1024780468 832 dbSNP
rs971487857 833 dbSNP
rs1331645324 834 dbSNP
rs1240593067 837 dbSNP
rs1440821691 840 dbSNP
rs982929716 842 dbSNP
rs1235088120 844 dbSNP
rs541282292 845 dbSNP
rs374401856 854 dbSNP
rs907711358 857 dbSNP
rs974768663 858 dbSNP
rs1377608903 860 dbSNP
rs1395376682 862 dbSNP
rs532951137 865 dbSNP
rs1310385530 880 dbSNP
rs1204791621 886 dbSNP
rs548000962 887 dbSNP
rs932466823 888 dbSNP
rs1484098911 889 dbSNP
rs1315625880 891 dbSNP
rs932276035 893 dbSNP
rs1050796662 896 dbSNP
rs17163112 898 dbSNP
rs1200400995 904 dbSNP
rs563270105 913 dbSNP
rs941473752 919 dbSNP
rs1425959053 921 dbSNP
rs78094079 923 dbSNP
rs945153828 932 dbSNP
rs1042192253 934 dbSNP
rs371742047 935 dbSNP
rs1423244345 937 dbSNP
rs1476947612 938 dbSNP
rs1201372749 940 dbSNP
rs140159347 947 dbSNP
rs1014213694 954 dbSNP
rs1465557274 956 dbSNP
rs61785869 957 dbSNP
rs111667462 958 dbSNP
rs895073371 962 dbSNP
rs1396409768 963 dbSNP
rs1013307081 970 dbSNP
rs1024335131 974 dbSNP
rs1220074957 979 dbSNP
rs1278372493 981 dbSNP
rs971458428 984 dbSNP
rs1311109434 989 dbSNP
rs1230385697 995 dbSNP
rs1254791810 998 dbSNP
rs1004333735 1005 dbSNP
rs1484514688 1008 dbSNP
rs1033617001 1012 dbSNP
rs1262918263 1025 dbSNP
rs10494394 1026 dbSNP
rs1011043229 1028 dbSNP
rs534988120 1029 dbSNP
rs974277636 1030 dbSNP
rs1173982046 1036 dbSNP
rs921486869 1042 dbSNP
rs922510342 1051 dbSNP
rs954123023 1053 dbSNP
rs1358408309 1073 dbSNP
rs985300618 1092 dbSNP
rs551756930 1093 dbSNP
rs941223927 1096 dbSNP
rs764604300 1098 dbSNP
rs986856033 1099 dbSNP
rs1366414618 1100 dbSNP
rs571825905 1108 dbSNP
rs1298555598 1115 dbSNP
rs1302730935 1126 dbSNP
rs774585267 1128 dbSNP
rs762162724 1129 dbSNP
rs1285858652 1132 dbSNP
rs1351963936 1143 dbSNP
rs1042161298 1147 dbSNP
rs1242938329 1153 dbSNP
rs537279736 1162 dbSNP
rs906104160 1163 dbSNP
rs1489088852 1176 dbSNP
rs555973200 1184 dbSNP
rs1157979380 1188 dbSNP
rs925039870 1191 dbSNP
rs767788666 1193 dbSNP
rs1260055712 1195 dbSNP
rs1378362822 1198 dbSNP
rs1464762986 1199 dbSNP
rs1159540418 1215 dbSNP
rs1421311174 1215 dbSNP
rs557509413 1217 dbSNP
rs936472108 1225 dbSNP
rs1433850506 1226 dbSNP
rs376006959 1232 dbSNP
rs1367708235 1235 dbSNP
rs1054982889 1248 dbSNP
rs1189649315 1255 dbSNP
rs1391583400 1264 dbSNP
rs895034964 1266 dbSNP
rs182324466 1272 dbSNP
rs1442416002 1273 dbSNP
rs187347421 1276 dbSNP
rs1020709189 1277 dbSNP
rs1163380923 1281 dbSNP
rs113975812 1282 dbSNP
rs1459368723 1283 dbSNP
rs569672944 1284 dbSNP
rs1236338773 1288 dbSNP
rs148860823 1288 dbSNP
rs1177640903 1295 dbSNP
rs953753118 1296 dbSNP
rs570669317 1301 dbSNP
rs1004217844 1302 dbSNP
rs1322314975 1304 dbSNP
rs1464664933 1305 dbSNP
rs1367535387 1307 dbSNP
rs1394572012 1308 dbSNP
rs1398791665 1313 dbSNP
rs557803615 1313 dbSNP
rs1444983204 1315 dbSNP
rs116651280 1316 dbSNP
rs962840123 1326 dbSNP
rs1322453818 1327 dbSNP
rs1378910377 1328 dbSNP
rs1226926076 1333 dbSNP
rs1247584378 1335 dbSNP
rs1315135841 1345 dbSNP
rs996056604 1347 dbSNP
rs962829132 1352 dbSNP
rs770627412 1356 dbSNP
rs1028515243 1362 dbSNP
rs754750260 1379 dbSNP
rs954429775 1380 dbSNP
rs1205155973 1383 dbSNP
rs987048489 1385 dbSNP
rs142561602 1387 dbSNP
rs1311752615 1391 dbSNP
rs1250299950 1393 dbSNP
rs563486248 1394 dbSNP
rs1477273448 1405 dbSNP
rs1167998003 1406 dbSNP
rs150991248 1408 dbSNP
rs79516637 1409 dbSNP
rs1330187145 1411 dbSNP
rs558944390 1413 dbSNP
rs528042378 1419 dbSNP
rs190218064 1423 dbSNP
rs764898340 1427 dbSNP
rs1446345976 1431 dbSNP
rs1424998079 1432 dbSNP
rs1315144425 1436 dbSNP
rs936456476 1439 dbSNP
rs1218235914 1442 dbSNP
rs1276478073 1443 dbSNP
rs867924638 1445 dbSNP
rs1320098040 1449 dbSNP
rs754871867 1450 dbSNP
rs991046969 1451 dbSNP
rs79909517 1452 dbSNP
rs949325353 1459 dbSNP
rs778903106 1460 dbSNP
rs1046307375 1461 dbSNP
rs140993675 1462 dbSNP
rs1171460445 1471 dbSNP
rs1425133282 1473 dbSNP
rs115114623 1474 dbSNP
rs368021271 1477 dbSNP
rs569230896 1477 dbSNP
rs1376461617 1478 dbSNP
rs748011894 1479 dbSNP
rs898557553 1481 dbSNP
rs13886 1486 dbSNP
rs1017254992 1487 dbSNP
rs962695371 1495 dbSNP
rs550903949 1496 dbSNP
rs1397811308 1506 dbSNP
rs1352721375 1512 dbSNP
rs972519393 1513 dbSNP
rs1264947336 1517 dbSNP
rs1025458135 1525 dbSNP
rs1197629345 1528 dbSNP
rs971216795 1530 dbSNP
rs1478693155 1534 dbSNP
rs553961307 1535 dbSNP
rs1349691354 1536 dbSNP
rs7414413 1539 dbSNP
rs772695080 1539 dbSNP
rs1028903777 1544 dbSNP
rs890002078 1549 dbSNP
rs927401923 1554 dbSNP
rs1401499314 1563 dbSNP
rs777606655 1565 dbSNP
rs1329430251 1570 dbSNP
rs1443108497 1576 dbSNP
rs567814738 1580 dbSNP
rs1304099685 1581 dbSNP
rs1229624403 1587 dbSNP
rs1270404296 1591 dbSNP
rs990207001 1593 dbSNP
rs1310866055 1595 dbSNP
rs536766960 1599 dbSNP
rs914791220 1600 dbSNP
rs746689765 1601 dbSNP
rs553471091 1611 dbSNP
rs1042005701 1614 dbSNP
rs566956642 1615 dbSNP
rs966948997 1618 dbSNP
rs1193657741 1622 dbSNP
rs1254229900 1625 dbSNP
rs977707687 1628 dbSNP
rs1179299966 1630 dbSNP
rs1032034217 1633 dbSNP
rs1365898518 1637 dbSNP
rs770567194 1648 dbSNP
rs1162893307 1650 dbSNP
rs538687060 1653 dbSNP
rs1463124863 1657 dbSNP
rs1236653933 1660 dbSNP
rs916319018 1666 dbSNP
rs576986152 1667 dbSNP
rs558910693 1668 dbSNP
rs981955439 1671 dbSNP
rs745318486 1672 dbSNP
rs907770209 1689 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agGUCACCAAGAAUUGUCAAGuu 5'
            || |||   | :|||||||  
Target 5' cuCACUGG-AAUGGACAGUUC-- 3'
 		21 - 40
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000253063.3 | 3UTR | AAGCCACACCCUCCCUUUUCCUCACUGGAAUGGACAGUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
154 hsa-miR-203b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT063500 SKI SKI proto-oncogene 2 4
MIRT149737 LDLR low density lipoprotein receptor 2 6
MIRT206557 SOCS5 suppressor of cytokine signaling 5 2 8
MIRT248820 SESN2 sestrin 2 2 2
MIRT261314 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT443290 TAF8 TATA-box binding protein associated factor 8 2 4
MIRT443893 NUDT3 nudix hydrolase 3 2 4
MIRT444057 SERPINA4 serpin family A member 4 2 2
MIRT444345 KIAA1211 KIAA1211 2 2
MIRT444538 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT444594 TGFA transforming growth factor alpha 2 2
MIRT445601 SEC14L3 SEC14 like lipid binding 3 2 2
MIRT446025 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT446309 TBC1D8B TBC1 domain family member 8B 2 2
MIRT446492 TMEM215 transmembrane protein 215 2 4
MIRT446728 SLC36A4 solute carrier family 36 member 4 2 2
MIRT447468 CISD2 CDGSH iron sulfur domain 2 2 2
MIRT447504 MRPS5 mitochondrial ribosomal protein S5 2 2
MIRT447597 MRPL3 mitochondrial ribosomal protein L3 2 2
MIRT447636 AGPS alkylglycerone phosphate synthase 2 2
MIRT447846 ZRANB2 zinc finger RANBP2-type containing 2 2 2
MIRT448098 TCN2 transcobalamin 2 2 2
MIRT448111 SEMA4G semaphorin 4G 2 2
MIRT448903 CLCN6 chloride voltage-gated channel 6 2 4
MIRT449396 TOX4 TOX high mobility group box family member 4 2 2
MIRT449484 CACNA2D4 calcium voltage-gated channel auxiliary subunit alpha2delta 4 2 2
MIRT450705 RNF152 ring finger protein 152 2 2
MIRT450781 PAPOLG poly(A) polymerase gamma 2 2
MIRT452856 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453048 TANGO2 transport and golgi organization 2 homolog 2 2
MIRT459389 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT461156 SLC11A2 solute carrier family 11 member 2 2 4
MIRT461613 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT463711 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 8
MIRT464107 VPS35 VPS35, retromer complex component 2 2
MIRT466438 TFAM transcription factor A, mitochondrial 2 2
MIRT467735 SLC36A1 solute carrier family 36 member 1 2 2
MIRT469512 RBFOX2 RNA binding protein, fox-1 homolog 2 2 6
MIRT470026 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT473411 MDM4 MDM4, p53 regulator 2 2
MIRT480545 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT488444 ACBD3 acyl-CoA binding domain containing 3 2 2
MIRT489498 CRLF3 cytokine receptor like factor 3 2 4
MIRT496149 RPS15A ribosomal protein S15a 2 2
MIRT497013 PRDM2 PR/SET domain 2 2 2
MIRT497087 PHF12 PHD finger protein 12 2 2
MIRT508695 MTRNR2L4 MT-RNR2-like 4 2 4
MIRT517468 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT525329 CNGB1 cyclic nucleotide gated channel beta 1 2 2
MIRT527842 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT529111 AQPEP laeverin 1 1
MIRT530163 C11orf44 chromosome 11 open reading frame 44 2 4
MIRT532249 TBPL2 TATA-box binding protein like 2 2 2
MIRT532828 ZNF704 zinc finger protein 704 2 2
MIRT533140 WNT10A Wnt family member 10A 2 2
MIRT536481 KIAA1468 KIAA1468 2 2
MIRT536802 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT537301 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT542650 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT545691 NUTF2 nuclear transport factor 2 2 2
MIRT546960 PRR14L proline rich 14 like 2 2
MIRT560566 ZNF460 zinc finger protein 460 2 2
MIRT561792 PAWR pro-apoptotic WT1 regulator 2 2
MIRT562372 ERI2 ERI1 exoribonuclease family member 2 2 2
MIRT569292 SURF6 surfeit 6 2 2
MIRT574090 VASN vasorin 2 2
MIRT619787 HLCS holocarboxylase synthetase 2 2
MIRT620104 HARBI1 harbinger transposase derived 1 2 2
MIRT626003 ZNF517 zinc finger protein 517 2 2
MIRT626375 BBS1 Bardet-Biedl syndrome 1 2 2
MIRT626615 SLC30A6 solute carrier family 30 member 6 2 2
MIRT628381 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT629299 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT630439 IDE insulin degrading enzyme 2 2
MIRT631848 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT633171 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT633472 ZNF724P zinc finger protein 724 2 2
MIRT634389 PLSCR1 phospholipid scramblase 1 2 2
MIRT635536 TRIM72 tripartite motif containing 72 2 2
MIRT635818 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT636165 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636792 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT637946 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT640317 STAT1 signal transducer and activator of transcription 1 2 2
MIRT645131 HES2 hes family bHLH transcription factor 2 2 2
MIRT645658 ADK adenosine kinase 2 2
MIRT646143 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT646999 NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2 2
MIRT648183 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT650085 TERF2 telomeric repeat binding factor 2 2 2
MIRT650326 RTN2 reticulon 2 2 2
MIRT651562 WHSC1L1 nuclear receptor binding SET domain protein 3 2 2
MIRT659367 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT659830 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT662103 LACTB lactamase beta 2 4
MIRT664837 HUS1 HUS1 checkpoint clamp component 2 2
MIRT669750 ZNF101 zinc finger protein 101 2 4
MIRT669791 GAN gigaxonin 2 2
MIRT670044 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT670293 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670382 EMP2 epithelial membrane protein 2 2 2
MIRT670950 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 4
MIRT672854 C22orf29 retrotransposon Gag like 10 2 2
MIRT672885 FXN frataxin 2 2
MIRT673994 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT674155 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT674495 TIRAP TIR domain containing adaptor protein 2 2
MIRT675461 NUBPL nucleotide binding protein like 2 2
MIRT675669 TMOD2 tropomodulin 2 2 2
MIRT675994 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676069 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676378 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676759 SNX2 sorting nexin 2 2 2
MIRT676893 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT676973 ZNF708 zinc finger protein 708 2 2
MIRT677229 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677363 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT677456 PDLIM3 PDZ and LIM domain 3 2 2
MIRT678073 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678091 ATCAY ATCAY, caytaxin 2 2
MIRT678316 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678411 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678519 ZNF347 zinc finger protein 347 2 2
MIRT678695 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT678821 PDE6A phosphodiesterase 6A 2 2
MIRT679984 RUNDC1 RUN domain containing 1 2 2
MIRT680608 KIAA0391 KIAA0391 2 2
MIRT680724 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT681238 ZNF383 zinc finger protein 383 2 2
MIRT681932 SLC19A3 solute carrier family 19 member 3 2 2
MIRT682003 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT682500 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 2
MIRT685460 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT688193 FNIP1 folliculin interacting protein 1 2 2
MIRT689666 RBM23 RNA binding motif protein 23 2 2
MIRT691058 CRCP CGRP receptor component 2 2
MIRT691442 CXorf36 chromosome X open reading frame 36 2 2
MIRT695998 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT696395 CORO7 coronin 7 2 2
MIRT702334 KLHL7 kelch like family member 7 2 2
MIRT702555 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT703362 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT703551 FKBP14 FK506 binding protein 14 2 2
MIRT705029 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT706335 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT708907 TM4SF19 transmembrane 4 L six family member 19 2 2
MIRT711625 CORO1C coronin 1C 2 2
MIRT714444 TOPAZ1 testis and ovary specific PAZ domain containing 1 2 2
MIRT716324 POU5F1 POU class 5 homeobox 1 2 2
MIRT718568 SLC25A22 solute carrier family 25 member 22 2 2
MIRT720299 DDHD1 DDHD domain containing 1 2 2
MIRT721449 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT723529 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT724492 BFAR bifunctional apoptosis regulator 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-203b Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 down-regulated
miR-203b 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-203b-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-203b-3p Fluorouracil 3385 NSC19893 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-203b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-203b-3p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-203b-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-203b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CP20)
hsa-miR-203b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-203b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-203b-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-203b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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